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snapshot in surgery: brain abscess as a complication of a recurrent sigmoid diverticular abscess.a 35-year-old man was found to have a cerebral abscess secondary to a recurrent sigmoid diverticular abscess. both cultures grew streptococcus anginosus. brain abscess is a rare but potential complication of sigmoid diverticulitis. streptococcus anginosus, which is found in human gut flora, is a common cause of brain abscess.201526185659
streptococcus constellatus causing septic thrombophlebitis of the right ovarian vein with extension into the inferior vena cava.introduction. streptococcus constellatus collectively with streptococcus anginosus and streptococcus intermedius constitute the streptococcus anginosus (formerly streptococcus milleri) group. though they are commonly associated with abscesses, bacteremia with subsequent septic thrombophlebitis is extremely rare, and resulting mortality is infrequent. case presentation. we report a case of a previously healthy 60-year-old african american female who presented with streptococcus constellatus bacte ...201526171262
optimized protocol for pfge analysis of anginosus (milleri) streptococci.streptococcus anginosus (milleri) is a diverse group of gram positive bacteria. molecular methods to establish relationship between strains are poorly developed. therefore, main tool to study genetic variability is restriction fragment length polymorphism combined with pulsed field gel electrophoresis (rflp-pfge). in this communication, we present optimized protocol for s. anginosus pfge analysis.201526094317
how an opportunistic infection can mess with your brain and take your breath away: a rare case of simultaneous lung and brain abscess due to streptococcus anginosus.streptococcus anginosus (s. anginosus) is considered a friendly bug and is a one of many different bacteria that constitute the normal flora of the oral cavity. nevertheless, it has been infrequently associated with more invasive infections, like lung abscess. it is extremely rare to have multisystemic involvement with s. anginosus group. we present a unique case of pulmonary and brain abscess due to s. anginosus in an immunocompetent patient.201525922772
pyogenic brain abscess due to streptococcus anginosus. 201525758701
ventricular septal defect and bivalvular endocarditis.a 63-year-old man presented with generalized fatigue, chills, malaise, dyspnea, intermittent fevers, and 50-pound weight loss of 4 months' duration. blood cultures were positive for pan-sensitive streptococcus anginosus. transesophageal echocardiography showed an 11 mm × 3 mm mobile mass attached to the mitral valve, a 16 mm × 16 mm mobile mass attached to the pulmonary valve, and a small membranous ventricular septal defect. the patient received 12 weeks of intravenous (iv) antibiotics with eve ...201725625086
simultaneous bilateral decortications via video-assisted thoracic surgery for bilateral empyema.bilateral empyema is a rare and life-threatening condition that is difficult to treat. we herein report a case of bilateral empyema that was treated with simultaneous bilateral decortications via video-assisted thoracic surgery (vats).201525528031
subperiosteal abscess of the orbit: evolving pathogens and the therapeutic protocol.because of widespread antibiotic use, immunization against selective species, and the emergence of hypervirulent organisms, we sought to determine changes over time in the bacteriology of sinusitis-related subperiosteal abscess (spa) of the orbit and their impact on patient outcomes under a uniform management protocol.201525439602
streptolysin s of streptococcus anginosus exhibits broad-range hemolytic activity.streptococcus anginosus is a commensal of mucous membranes and an emerging human pathogen. some strains, including the type strain, display a prominent β-hemolytic phenotype. a gene cluster (sag), encoding a variant of streptolysin s (sls) has recently been identified as the genetic background for β-hemolysin production in s. anginosus. in this study, we further characterized the hemolytic and cytolytic activity of the s. anginosus hemolysin in comparison with other streptococcal hemolysins. the ...201525381594
streptococcus anginosus infections: crossing tissue planes.streptococcus anginosus has long been recognized to cause invasive pyogenic infections. this holds true for thoracic infections where s. anginosus has a propensity for abscess and empyema formation. early diagnosis is important given the significant morbidity and mortality associated with thoracic s. anginosus infections. yet, distinguishing thoracic s. anginosus clinically is difficult. we present three cases of thoracic s. anginosus that demonstrated radiographic extension across tissue planes ...201425288003
secondary aortoduodenal fistula following endovascular repair of inflammatory abdominal aortic aneurysm due to streptococcus anginosus infection: a case report and literature review.aortoenteric fistula is a rare but very serious complication of both surgical and endovascular abdominal aortic reconstruction. since the advent of endovascular abdominal aortic aneurysm repair (evar), 20 cases of aortoduodenal fistula associated with aortic stent grafts have been reported.(1) however, only a handful has been reported following inflammatory abdominal aortic aneurysm repair. it most commonly presents with bleeding, usually from the upper gastro-intestinal tract. with recent advan ...201425201477
streptococcus intermedius bacteremia and liver abscess following a routine dental cleaning.streptococcus intermedius is a member of the streptococcus anginosus group of bacteria. this group is part of the normal flora of the oropharynx, genitourinary, and gastrointestinal tracts; however, they have been known to cause a variety of purulent infections including meningitis, endocarditis, and abscesses, even in immunocompetent hosts. in particular, s. intermedius has been associated with the development of liver and brain abscesses. there have been several case reports of s. intermedius ...201425197585
neurological picture. multiple intracranial arteritis and hypothyroidism secondary to streptococcus anginosus infection. 201525143631
molecular analysis of streptococcus anginosus-derived saga peptides.saga1 and saga2 molecules produced from beta-hemolytic streptococcus anginosus subsp. anginosus are composed of a leader peptide and a propeptide, and their mature form has hemolytic activity as a well-known streptococcal peptide toxin, streptolysin. the function of these saga molecules is thought to be dependent on intra-molecular heterocycle formation. in this study, we examined the heterocycle-involved molecular features of saga1, saga2, and s. pyogenes saga (spysaga), focusing on their heter ...201425075110
development of species-specific quantitative real-time pcr primers for detecting anginosus group streptococci based on the rpob.in this study, we introduced species-specific quantitative real-time pcr (qpcr) primers designed based on a dna-dependent rna polymerase beta-subunit gene for detecting anginosus group streptococci (ags), streptococcus anginosus, s. constellatus, and s. intermedius. the specificity of the qpcr primers was confirmed by conventional pcr with the genomic dnas of 76 strains regarding 44 bacterial species including the type strain for the target species. the standard curves revealed the lower detecti ...201424942606
identification of the 'streptococcus anginosus group' by matrix-assisted laser desorption ionization--time-of-flight mass spectrometry.matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof ms) provides rapid, accurate and cost-effective identification of a range of bacteria and is rapidly changing the face of routine diagnostic microbiology. however, certain groups of bacteria, for example streptococci (in particular viridans or non-haemolytic streptococci), are less reliably identified by this method. we studied the performance of maldi-tof ms for identification of the 'streptococcus anginosus ...201424917618
the potential role of lung microbiota in lung cancer attributed to household coal burning exposures.bacteria influence site-specific disease etiology and the host's ability to metabolize xenobiotics, such as polycyclic aromatic hydrocarbons (pahs). lung cancer in xuanwei, china has been attributed to pah-rich household air pollution from burning coal. this study seeks to explore the role of lung microbiota in lung cancer among never smoking xuanwei women and how coal burning may influence these associations. dna from sputum and buccal samples of never smoking lung cancer cases (n = 8, in dupli ...201424895247
molecular pathogenicity of streptococcus anginosus.streptococcus anginosus and the closely related species streptococcus constellatus and streptococcus intermedius, are primarily commensals of the mucosa. the true pathogenic potential of this group has been under-recognized for a long time because of difficulties in correct species identification as well as the commensal nature of these species. in recent years, streptococci of the s. anginosus group have been increasingly found as relevant microbial pathogens in abscesses and blood cultures and ...201424848553
telavancin: mechanisms of action, in vitro activity, and mechanisms of resistance.telavancin is a semisynthetic lipoglycopeptide derivative of vancomycin. telavancin has a dual mechanism of antibacterial action, disrupting peptidoglycan synthesis and cell membrane function. in 2014, the clinical and laboratory standards institute (clsi) revised the antimicrobial susceptibility testing method for telavancin, resulting in minimum inhibitory concentration (mic) determinations that are more accurate and reproducible and demonstrate greater in vitro potency than shown with the pre ...201526316559
chromosomal islands of streptococcus pyogenes and related streptococci: molecular switches for survival and virulence.streptococcus pyogenes is a significant pathogen of humans, annually causing over 700,000,000 infections and 500,000 deaths. virulence in s. pyogenes is closely linked to mobile genetic elements like phages and chromosomal islands (ci). s. pyogenes phage-like chromosomal islands (spyci) confer a complex mutator phenotype on their host. spyci integrate into the 5' end of dna mismatch repair (mmr) gene mutl, which also disrupts downstream operon genes lmrp, ruva, and tag. during early logarithmic ...201425161960
[management of nasal orbital cellulitis in children].to analyze the clinical characteristics, diagnostic and treatment principle of orbital cellulitis in children, and to improve the experience of antibiotic treatment in orbital cellulites.201525764921
solitary pyomyositis of the left rhomboideus muscle caused by streptococcus anginosus and streptococcus intermedius in an immunocompetent person.primary pyomyositis is a bacterial infection of the skeletal muscle commonly affecting children with staphylococcus aureus most often isolated as a pathogen. however, pyomyositis caused by anaerobic bacteria is rare in adults. here, we report a case of solitary pyomyositis of the left rhomboideus muscle in an immunocompetent person. a 70-year-old japanese male presented with high fever and left shoulder pain. his muscle below the lower edge of the left scapula was tender and swollen. his laborat ...201526185692
cavernosal abscess due to streptococcus anginosus: a case report and comprehensive review of the literature.corpus cavernosum abscesses are uncommon with only 23 prior reports in the literature. several precipitating factors for cavernosal infections have been described including injection therapy for erectile dysfunction, trauma, and priapism. common causal organisms include staphylococcus aureus, streptococci, and bacteroides. we report a unique case of a corpus cavernosum abscess due to proctitis with hematological seeding and review the literature on cavernosal abscesses.201324917758
surrogate analysis of vancomycin to predict susceptible categorization of dalbavancin.dalbavancin (dal) represents a recently approved addition for the treatment of acute bacterial skin and skin structure infections (absssis). newly released antimicrobial agents are rarely found on commercial susceptibility testing devices, and surrogate testing may be an option for clinical microbiology laboratories. a total of 33,688 staphylococcus aureus, 2800 viridans group streptococci (vgs), and 5722 β-hemolytic streptococci (bhs) were included in this cross-susceptibility (dal versus vanco ...201525724854
antibiotic susceptibilities, streptococcal pyrogenic exotoxin gene profiles among clinical isolates of group c or g streptococcus dysgalactiae subsp. equisimilis & of group g s. anginosus group at a tertiary care centre.group c and group g streptococci (together gcgs) are often regarded as commensal bacteria and their role in streptococcal disease burden is under-recognized. while reports of recovery of gcgs from normally sterile body sites are increasing, their resistance to macrolides, fluoroquinolone further warrants all invasive β haemolytic streptococci to be identified to the species level and accurately tested for antimicrobial susceptibility. this study was aimed to determine the prevalence, clinical pr ...201424820839
bacterial profile of dentine caries and the impact of ph on bacterial population diversity.dental caries is caused by the release of organic acids from fermentative bacteria, which results in the dissolution of hydroxyapatite matrices of enamel and dentine. while low environmental ph is proposed to cause a shift in the consortium of oral bacteria, favouring the development of caries, the impact of this variable has been overlooked in microbial population studies. this study aimed to detail the zonal composition of the microbiota associated with carious dentine lesions with reference t ...201424675997
an unusual case of streptococcus anginosus group pyomyositis diagnosed using direct 16s ribosomal dna sequencing.bacteria belonging to the streptococcus anginosus group (streptococcus intermedius, streptococcus constellatus and streptococcus anginosus) are capable of causing serious pyogenic infections, with a tendency for abscess formation. the present article reports a case of s anginosus group pyomyositis in a 47-year-old man. the pathogen was recovered from one of two blood cultures obtained from the patient, but speciation was initially not performed because the organism was considered to be a contami ...201424634686
a streptolysin s homologue is essential for β-haemolytic streptococcus constellatus subsp. constellatus cytotoxicity.streptococcus constellatus is a member of the anginosus group streptococci (ags) and primarily inhabits the human oral cavity. s. constellatus is composed of three subspecies: s. constellatus subsp. constellatus (scc), s. constellatus subsp. pharyngis and the newly described subspecies s. constellatus subsp. viborgensis. although previous studies have established that scc contains β-haemolytic strains, the factor(s) responsible for β-haemolysis in β-haemolytic scc (β-scc) has yet to be clarified ...201424600025
streptococcus anginosus pyogenic liver abscess following a screening colonoscopy.a previously healthy 58-year-old man presented with a septic thrombosis of the right hepatic vein and a pyogenic liver abscess (pla) one week after undergoing a screening colonoscopy. blood cultures and a radiological drainage specimen were both positive for streptococcus anginosus. evolution was favourable after six weeks of antibiotherapy. to the authors' knowledge, the present report is the first to describe a pla following a screening colonoscopy with no intervention. the authors hypothesize ...201324421818
pneumonia and empyema caused by streptococcus intermedius that shows the diagnostic importance of evaluating the microbiota in the lower respiratory tract.the bacterial species in the streptococcus anginosus group (s. constellatus, s. anginosus, s. intermedius) are important causative pathogens of bacterial pneumonia, pulmonary abscesses and empyema. however, the bacteria in this group are primarily oral resident bacteria and unable to grow significantly on ordinary aerobic culture media. we experienced a case of pneumonia and empyema caused by streptococcus intermedius detected using a 16s rrna gene sequencing analysis of bronchoalveolar lavage f ...201424390528
descending necrotizing mediastinitis: a modified algorithmic approach to define a new standard of care.descending necrotizing mediastinitis (dnm) is a highly morbid infectious process. this uncommon disease process has carried historically a substantial burden of morbidity and mortality. in this study we hypothesized that application of a prospective modified management algorithm would decrease the morbidity and mortality from this highly destructive process.201324351133
phylogenetic relationship and virulence inference of streptococcus anginosus group: curated annotation and whole-genome comparative analysis support distinct species designation.the streptococcus anginosus group (sag) represents three closely related species of the viridans group streptococci recognized as commensal bacteria of the oral, gastrointestinal and urogenital tracts. the sag also cause severe invasive infections, and are pathogens during cystic fibrosis (cf) pulmonary exacerbation. little genomic information or description of virulence mechanisms is currently available for sag. we conducted intra and inter species whole-genome comparative analyses with 59 publ ...201324341328
streptococcus anginosus, tooth extraction and brain abscess. 201424334300
oral status in patients with early rheumatoid arthritis: a prospective, case-control study.patients with ra suffer from a higher risk of periodontal attachment loss and increased oral inflammation. we hypothesize that there are pathogenetic and immunological interactions between these diseases that go beyond impaired manual dexterity accompanying advanced ra. the primary objective of the present study was to determine whether a loss of alveolar bone can be detected in ra patients during the early course of the disease.201424273047
invasive streptococcus anginosus group infection-does the species predict the outcome?to determine whether there is an association between the species of streptococcus anginosus group (sag) bacteria and the clinical outcome.201424215937
fatal streptococcus anginosus-associated pneumonia in a captive sumatran orangutan (pongo abelii).bacterial infections commonly affect the lungs and air sacs of orangutans; culture and identification is rarely performed and may have clinical relevance.201424117447
iatrogenic sinistral hypertension complicating screening colonoscopy.colonoscopy is widely accepted as the gold-standard screening technique for detecting malignancies in the distal gastrointestinal tract in patients with symptoms suggestive of colon cancer. however, this procedure is not without risk, including colonic perforation. we report a patient who was managed conservatively after colonoscopy induced perforation. eighteen months after appearing to make a full recovery, he presented with an upper gastrointestinal bleed. oesophago-gastro-duodenoscopy (ogd) ...201324024063
fournier's gangrene of the penis caused by streptococcus dysgalactiae subspecies equisimilis: case report and incidence study in a tertiary-care hospital.fournier's gangrene is a rare necrotizing soft tissue infection of the scrotum and penis. we report, to our knowledge, the first case of fournier's gangrene caused by streptococcus dysgalactiae subsp. equisimilis (sdse), a strain of pyogenic β-hemolytic streptococci that is increasingly being recognized as an important human pathogen.201323957431
[three cases of liver abscess associated with the streptococcus anginosus group].reports of pyogenic liver abscess (pla) caused by the streptococcus anginosus group (sag) have increased. coinfection with sag and anaerobic bacteria enhances the tendency for abscess formation. furthermore, it has been reported that sag infection results in pylethrombophlebitis as a complication. we experienced 3 cases of pla caused by sag: one case was complicated by the development of pylethrombophlebitis and the other 2 cases had coinfection with anaerobic bacteria. we report these cases tog ...201323912007
identification, clinical aspects, susceptibility pattern, and molecular epidemiology of beta-haemolytic group g streptococcus anginosus group isolates from central taiwan.no literature is available on the prevalence and clinical aspects of beta-haemolytic group g streptococcus anginosus group in central taiwan. in this study, we used 16s rrna gene sequencing and 16s-23s rdna intergenic spacer sequencing (where necessary) as the gold standard for molecular identification. twenty-seven s. anginosus group isolates were identified from 273 beta-haemolytic ggs isolates collected from patients in central taiwan between february 2007 and august 2011. of the 27 isolates, ...201323632249
identification of β-haemolysin-encoding genes in streptococcus anginosus.streptococcus anginosus is an emerging pathogen, but little is known about its virulence factors. to detect the genes responsible for β-haemolysis we performed genomic mutagenesis of the β-haemolytic s. anginosus type strain atcc 12395 using the vector pghost9:iss1. integration site analysis of 15 non-haemolytic mutants identified a gene cluster with high homology to the genes of the streptolysin s (sls) encoding sag gene cluster of s. pyogenes. the gene cluster harbours 10 open reading frames d ...201323594064
a silent acute abdomen in a patient with spinal cord injury.a 52-year-old man with cervical spondylosis sustained a hyperextension injury to the neck and subsequently developed central cord syndrome after 2 weeks. the diagnosis was confirmed clinically and on mri. during the admission he was febrile from streptococcus anginosus bacteraemia from a gum infection and was started on penicillin. this resulted in pseudomembranous colitis with abdominal distension and bloody diarrhoea but a lack of expected abdominal complaints. unfortunately his neurology dete ...201323536647
streptococcus anginosus group and osteomyelitis: a single centre clinical experience.the streptococcus anginosus group comprises three species of bacteria classified within the viridans streptococci. this group is known for abscess formation and endocarditis. while a variety of sites in the body claim anginosus streptococci as an agent of infection, osteomyelitis is unusual. the objective of this study was to describe a series of patients with osteomyelitis due to s anginosus group pathogens in terms of demographics, comorbidities, presentation and outcomes.201323515349
two cases of bacterial suppurative thyroiditis caused by streptococcus anginosus.acute suppurative thyroiditis (ast) is a rare clinical condition. streptococcus anginosus has a propensity of producing empyema in the head and neck. here, we reported two cases of ast caused by s. anginosus. a 44-year-old man presented with anterior neck tender swelling and odynophagia for 12 days. he had thyrotoxicosis. he was initially diagnosed as thyroid cancer due to the misleading computed tomography report. fine needle aspiration (fna) yielded pus and neutrophils. s. anginosus was isolat ...201323435638
the significance of streptococcus anginosus group in intracranial complications of pediatric rhinosinusitis.to assess the significance of the streptococcus anginosus group in intracranial complications of pediatric patients with rhinosinusitis.201323429946
[streptococcus intermedius: a rare cause of brain abscess in children].streptococcus intermedius is a member of the streptococcus anginosus group, also known as the streptococcus milleri group. although this is a commensal agent of the mouth and upper airways, it has been recognized as an important pathogen in the formation of abscesses. however, it has rarely been involved in the formation of brain abscess in children. we report 4 pediatric cases of brain abscess caused by s. intermedius. three boys and 1 girl, all aged over 2 years, were admitted for a febrile me ...201323375710
novel twin streptolysin s-like peptides encoded in the sag operon homologue of beta-hemolytic streptococcus anginosus.streptococcus anginosus is a member of the anginosus group streptococci, which form part of the normal human oral flora. in contrast to the pyogenic group streptococci, our knowledge of the virulence factors of the anginosus group streptococci, including s. anginosus, is not sufficient to allow a clear understanding of the basis of their pathogenicity. generally, hemolysins are thought to be important virulence factors in streptococcal infections. in the present study, a sag operon homologue was ...201323292771
development of an ex vivo coculture system to model pulpal infection by streptococcus anginosus group bacteria.streptococcus anginosus group (sag) bacteria are opportunistic pathogens and a major cause of pulpal infection and subsequent abscess formation. understanding of the processes involved in sag oral infections has been limited by the lack of an appropriate model system.201323228257
taxonomy of the anginosus group of the genus streptococcus and description of streptococcus anginosus subsp. whileyi subsp. nov. and streptococcus constellatus subsp. viborgensis subsp. nov.the anginosus group of the genus streptococcus has been the subject of much taxonomic confusion, which has hampered the full appreciation of its clinical significance. the purpose of this study was to critically re-examine the taxonomy of the anginosus group, with special attention to β-haemolytic, lancefield group c strains, using multilocus sequence analysis (mlsa) combined with 16s rrna gene sequence and phenotypic analyses. phylogenetic analysis of concatenated sequences of seven housekeepin ...201323223817
microbiology and management of pediatric liver abscesses: two cases caused by streptococcus anginosus group.pyogenic liver abscesses in the pediatric population are rare occurrences in the developed world. we present two cases of previously healthy males presenting with fever and abdominal pain found to have liver abscesses due to organisms in the streptococcus anginosus group. the microbiology of s. anginosus along with the management and recommended treatment in children with liver abscesses is discussed.201223119195
antibacterial activity of various antibiotics against oral streptococci isolated in the oral cavity.a total of 550 oral streptococci: 270 streptococcus mitis, 110 streptococcus sanguis, 90 streptococcus anginosus, 50 streptococcus mutans, 30 streptococcus salivarius, were isolated from dental plaque and gengival crevices of patients and tested for their susceptibility to 12 β-lactam antibiotics and to 5 non-β-lactam antibiotics, using the microdiluition method. overall, a reduced susceptibility to penicillin was recorded in 13.4% of cases. the percentage of strains resistant to penicillin appe ...201723058035
presumed hydrogen sulfide-mediated neurotoxicity after streptococcus anginosus group meningitis.hydrogen sulfide is an environmental toxicant and gaseous neurotransmitter. it is produced enterically by sulfur-reducing bacteria and invasive pathogens including streptococcus anginosus group, salmonella and citrobacter. we describe putative focal hydrogen sulfide neurotoxicity after streptococcus constellatus meningitis, treated with adjunctive sodium nitrite and hyperbaric oxygen therapy.201323014355
streptococcus anginosus group disseminated infection: case report and review of literature.streptococcus anginosus group is widely known for its ability to cause invasive pyogenic infections. there are very few reports of disseminated infections sustained by members of this streptococcal group. we report a case of a highly disseminated infection and analyse previous literature reports. disseminated pyogenic infection has been defined as an infection affecting two or more of the following organs/systems: central nervous system, lung, liver and spleen. we performed a pubmed search using ...201222992554
pediatric focal intracranial suppuration: a uk single-center experience.brain abscess (ba) and subdural empyema (sde) are uncommon but clinically important conditions in childhood. treatment involves surgery and prolonged courses of antibiotics. there is no consensus on the optimal approach. the objective was to review management and outcome of ba and sde in a single uk center.201222864509
neurological picture. multiple intracranial abscesses due to streptococcus anginosus in a previously well individual. 201222851610
real-time monitoring of the adherence of streptococcus anginosus group bacteria to extracellular matrix decorin and biglycan proteoglycans in biofilm formation.members of the streptococcus anginosus group (sags) are significant pathogens. however, their pathogenic mechanisms are incompletely understood. this study investigates the adherence of sags to the matrix proteoglycans decorin and biglycan of soft gingival and alveolar bone. recombinant chondroitin 4-sulphate(c4s)-conjugated decorin and biglycan were synthesised using mammalian expression systems. c4s-conjugated decorin/biglycan and dermatan sulphate (ds) decorin/biglycan were isolated from ovin ...201222835945
[problems with identification of beta-hemolytic streptococcus resistant to bacitracin isolated from patients with pharyngitis].the genus streptococcus comprises a number of species characterized by a differential pathogenic potential. these bacteria can be considered as members of microbial physiological flora but they can also cause mild infections or severe, life threatening conditions. the majority of infections of streptococcal etiology are caused by beta-hemolysing species. the predominant causative agent of bacterial pharyngitis is streptococcus pyogenes. this species usually doesn't give rise to any identificatio ...201222808724
structural insights into catalysis by βc-s lyase from streptococcus anginosus.hydrogen sulfide (h(2)s) is a causative agent of oral malodor and may play an important role in the pathogenicity of oral bacteria such as streptococcus anginosus. in this microorganism, h(2)s production is associated with βc-s lyase (lcd) encoded by lcd gene, which is a pyridoxal 5'-phosphate (plp)-dependent enzyme that catalyzes the α,β-elimination of sulfur-containing amino acids. when lcd acts on l-cysteine, h(2)s is produced along with pyruvate and ammonia. to understand the h(2)s-producing ...201222674431
ascending necrotizing fasciitis of the face following odontogenic infection.necrotizing fasciitis (nf) of the face is a rare but extremely dangerous complication of dental infection associated with a nearly 30% mortality rate. this infection spreads rapidly along the superficial fascial planes of the head and neck and can lead to severe disfigurement. reports in the literature of cases of nf of the face caused by dental infection are few. we report such a case in a 36-year-old woman and review the current standards of diagnosis and management. the patient initially pres ...201222627436
endogenous endophthalmitis and liver abscesses.we present a case of endogenous endophthalmitis secondary to liver abscesses, in a patient with no previous medical comorbidities or risk factors for immunosuppression. the patient presented with acute painless loss of vision and feeling generally unwell. investigations revealed streptococcus anginosus-constellatus bacteraemia, and evidence of diverticular disease that likely predisposed to the liver abscesses. due to prompt diagnosis and administration of antibiotics, the patient had a good vis ...201222423344
milleri group streptococcus--a stepchild in the viridans family.the purpose of this investigation was to provide a comprehensive review of the pathogenic role and spectrum of disease of milleri group streptococci, with special attention to bloodstream invasion and to possible differential roles among the three species. all consecutive isolates of milleri group streptococci from any anatomic source, during a 37-month period, in a tertiary care teaching hospital in tel-aviv, israel, were thoroughly investigated. identification to the species level was performe ...201222391759
the epidemiology, antibiotic resistance and post-discharge course of peritonsillar abscesses in london, ontario.peritonsillar abscesses (pta) are a common complication of tonsillitis. recent global epidemiological data regarding ptas have demonstrated increasing antimicrobial resistance patterns. no similar studies have been conducted in canada and no canadian study has examined the post-discharge course of treated patients.201323663820
[streptococcus anginosus pancreatic abscess after dental extraction]. 201623726739
[bifrontal cerebritis and brain abscess caused by sreptococcus anginosus group: report of one case].the etiology of brain abscesses is mostly polymicrobial. streptococci and anaerobic bacteria are the most commonly isolated pathogens. we report a previously healthy female without predisposing factors, presenting with a bifrontal cerebritis caused by a streptococcus anginosus group infection. the patient developed a brain abscess and a subdural collection with severe intracranial hypertension of fatal evolution. the etiologic diagnosis was made culturing the material obtained from the subdural ...201323732422
mucosal microbiome dysbiosis in gastric carcinogenesis.we aimed to characterise the microbial changes associated with histological stages of gastric tumourigenesis.201728765474
telavancin: a novel semisynthetic lipoglycopeptide agent to counter the challenge of resistant gram-positive pathogens.telavancin (td-6424), a semisynthetic lipoglycopeptide vancomycin-derivative, is a novel antimicrobial agent developed by theravance for overcoming resistant gram-positive bacterial infections, specifically methicillin-resistant staphylococcus aureus (mrsa). the us food and drug administration (usfda) had approved telavancin in 2009 for the treatment of complicated skin and skin structure infections (csssis) caused by gram-positive bacteria, including mrsa (s. aureus, streptococcus agalactiae, s ...201728634536
correction: modulation of behaviour and virulence of a high alginate expressing pseudomonas aeruginosa strain from cystic fibrosis by oral commensal bacterium streptococcus anginosus.[this corrects the article doi: 10.1371/journal.pone.0173741.].201728426833
the pyogenic potential of the different streptococcus anginosus group bacterial species: retrospective cohort study.streptococcus anginosus group (sag) bacteria are common causes of pyogenic infections (pis). we examined the association between sag species and the presence of a pi through a retrospective, observational, cohort study, between the years 2009 and 2015. all adults with clinically significant sag infections in one hospital in israel were assessed for association between sag species and the presence of a pi defined as an abscess, empyema, or deep/organ space surgical site infection. risk factors fo ...201728803566
[successful treatment of acute empyema due to rupture of pyogenic liver abscess].cases of rescue after rupture of pyogenic liver abscess into the thorax are rare. here, we report 2 cases of rescue in patients with acute empyema due to rupture of a suppurative abscess into the thorax. case 1:a 61-year-old male had high fever of 39 °c and right abdominal pain. thoracic computed tomography(ct) showed encapsulated pleural effusion in the right thorax and ring-like enhancement in the right liver. the diagnosis was acute empyema caused by rupture of liver abscess. the pathogenic b ...201728790240
how to become a killer, or is it all accidental? virulence strategies in oral streptococci.streptococci are a diverse group of gram-positive microorganisms sharing common virulence traits and similar strategies to escape the oral niche and establish an infection in other parts of the host organism. invasive infection with oral streptococci is "a perfect storm" that requires the concerted action of multiple biotic and abiotic factors. our understanding of streptococcal pathogenicity and infectivity should probably be less mechanistic and driven not only by the identification of novel v ...201728727895
rapid developing empyema by group f beta streptococcus anginosus group.a 43-year-old male had progressive pleuritic left-sided chest tightness with shortness of breath. he had dental caries and tenderness on palpation of the left lateral chest. complete blood count showed leucocytosis. ct scan of the chest with pulmonary emboli protocol showed multiple pulmonary nodules and nodular pleural thickening at left posterior lateral pleura. forty-eight hours post ctpe scan, ct scan of the chest, abdomen and pelvis displayed right lower lobe consolidation and left-sided pl ...201728705799
fournier's gangrene caused by streptococcus anginosus, a rare etiologic agent. 201728676193
tricuspid valve endocarditis partly due to a penicillin susceptible, ceftriaxone-resistant streptococcus anginosus isolate. 201728594647
unexpected brain finding in pre-autopsy postmortem ct.a case is presented in which pre-autopsy postmortem computed tomography (pmct) revealed an unexpected brain abscess with a related frontal sinusitis and an erosion of the posterior wall of the frontal sinus. pmct findings enabled the forensic pathologists to adapt protective measures during autopsy and protect their health from infection. pre-autopsy pmct has been also useful in the early differential diagnosis procedure. the complementary use of postmortem imaging and autopsy can improve the qu ...201728589523
bacteriostatic effect of simvastatin on selected oral streptococci in vitro.simvastatin is a widely used cholesterol-lowering drug, which has been found to have a number of pleiotropic effects. the aim of this study was to evaluate the antimicrobial effectiveness of simvastatin against selected oral streptococci as determined by the minimum inhibitory concentration (mic).201728566853
[streptococcal anginosus meningitis with a high-level resistance to cephalosporin of third generation]. 201728532641
pyogenic pericarditis and cardiac tamponade due to streptococcus anginosus in a combat theater.streptococcus anginosus group pericarditis is rare. a 24-year-old male soldier presented for care at a military clinic in afghanistan with shock and cardiac tamponade requiring emergent pericardial drainage and aeromedical evacuation. we review the patient's case, the need for serial pericardial drainage, and the available literature on this disorder.201728470013
spontaneous fracture of the femur due to osteomyelitis caused by the streptococcus anginosus group.a 57-year-old man was admitted because of pain in the right upper leg due to an osteolytic lesion of the femoral bone which was complicated by a spontaneous fracture. at first a malignancy was suspected. however, blood and bone cultures revealed the streptococcus anginosus group. a diagnosis of acute osteomyelitis was made. in spite of extensive antibiotic and surgical treatment the patient developed severe septic shock with multiple organ failure and died. in the case of a pathological fracture ...201728469049
renewal of peritonsillar abscess: impact of the bacterial species of the infection and clinical features of the patient-a prospective comparative aetiological study.to compare the bacterial species and patient clinical features in peritonsillar abscesses between patients who had renewal (renewal group) and those who did not (recovery group).201728464492
different frequencies of porphyromonas gingivalis infection in cancers of the upper digestive tract.the high incidence rate of multiple carcinomas in the upper digestive tract is often explained in terms of involvement of the same underlying risk factors. it has been reported that the oral bacterium streptococcus anginosus is associated with esophageal, gastric, and pharyngeal cancers. we previously reported occurrence of porphyromonas gingivalis (p. gingivalis) dna in esophagus cancer. in this study, the presence of p. gingivalis in specimens of various types of cancer from the upper digestiv ...201728705771
community composition determines activity of antibiotics against multispecies biofilms.in young cystic fibrosis (cf) patients, staphylococcus aureus is typically the most prevalent organism, while in adults, pseudomonas aeruginosa is the major pathogen. more recently, it was observed that also streptococcus anginosus plays an important role in exacerbations of respiratory symptoms. these species are often coisolated from cf lungs, yet little is known about whether antibiotic killing of one species is influenced by the presence of others. in the present study, we compared the activ ...201728696232
development of a multiplex pcr for identification of β-hemolytic streptococci relevant to human infections and serotype distribution of invasive streptococcus agalactiae in thailand.a multiplex polymerase chain reaction (mpcr) was developed for simultaneous detection (single reaction) of genes specific to five frequent clinically relevant β-hemolytic streptococcal species: streptococcus pyogenes (spy1258), streptococcus agalactiae (cfb and cpn60), streptococcus dysgalactiae subsp. equisimilis (16s-23s intergenic spacer) , s. equi subsp. zooepidemicus (esaa and sord), and streptococcus anginosus group (moac). no cross-reaction was observed with other bacterial species. this ...201728666619
splenic abscess caused by streptococcus anginosus following laparoscopic sleeve gastrectomy: a case report of a rare complication of bariatric surgery.splenic abscess as a complication of laparoscopic sleeve gastrectomy (lsg) is rare. there have only been six cases in the literature. in most of these cases, the classic predisposing factors for developing splenic abscess were absent, leading to the hypothesis that transient bacteraemia caused by mucosal disruption during the surgical procedure and splenic ischaemia may play a role. these patients usually present in the late post-operative period with abdominal pain, fever and leucocytosis. the ...201728458877
oesophageal cancer presenting as lemierre's syndrome caused by streptococcus anginosus.a 59-year-old man presented to the emergency department with complaints of dysphagia, right-sided neck swelling, fever and chills. physical examination was remarkable for fever and tender swelling over the right side of the neck. laboratory investigations revealed leucocytosis with neutrophilia. ct of the neck showed right internal jugular vein thrombosis with an overlying abscess and a nodular opacity in the right lung apex with air locules. he underwent surgical drainage of the neck abscess. a ...201728416472
gas-containing cervical epidural abscess accompanying bacterial meningitis in an adult.gas-containing spinal epidural abscesses are uncommon. moreover, acute spinal epidural abscesses rarely complicate bacterial meningitis in adults. here, we report a rare case of a gas-containing cervical epidural abscess accompanying bacterial meningitis. in spite of aggressive fluid and continuous antibiotic therapy after the isolation of streptococcus anginosus and streptococcus constellatus in the cerebrospinal fluid cultures, the patient showed remaining motor dysfunction and bladder involve ...201728407706
infective endocarditis with left to right intracardiac fistula due to streptococcus anginosus - a rare complication caused by an even rarer bacterium.although infective endocarditis (ie) has been described in reports dating from the renaissance, the diagnosis still challenges and the outcome often surprises. in the course of time, diagnostic criteria have been updated and validated to reduce misdiagnosis. some risk factors and epidemiology have shown dynamic changes since degenerative valvular disease became more predominant in developed countries, and the mean age of the affected population increased. despite streptococci have been being wel ...201728584802
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