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duodenal-mucosal bacteria associated with celiac disease in children.celiac disease (cd) is an immune-mediated enteropathy triggered by the ingestion of cereal gluten proteins. this disorder is associated with imbalances in the gut microbiota composition that could be involved in the pathogenesis of cd. the aim of this study was to characterize the composition and diversity of the cultivable duodenal mucosa-associated bacteria of cd patients and control children. duodenal biopsy specimens from patients with active disease on a gluten-containing diet (n = 32), pat ...201323835180
persistent epigastric pain in an 80-year-old man. 201121398231
breakthrough bacteremia and septic shock due to streptococcus anginosus resistant to daptomycin in a patient receiving daptomycin therapy.daptomycin is active against many gram-positive pathogens including multi-drug resistant organisms (3).…201121502623
two cases of aneurysm of the anterior mitral valve leaflet associated with transcatheter aortic valve endocarditis: a mere coincidence? 201020167335
[splenic gangrene due to streptococcus anginosus after a sleeve gastrectomy: report of one case.]we report a 46-year-old woman, subjected to a laparoscopic sleeve gastrectomy, that had to be converted to open surgery due to the presence of adherences. she required an immediate new intervention due to a hemoperitoneum caused by a liver tear and venous bleeding from the splenic hilus. both lesions were successfully repaired. in the postoperative period the patient had fever, leukocytosis and sialorrhea. a cat scan showed a splenic infarction and a huge intra abdominal collection that communic ...201121526304
evaluation of the nanosphere verigene gram-positive blood culture assay with the versatrek blood culture system and assessment of possible impact on selected patients.the verigene gram-positive blood culture (bc-gp) assay (nanosphere, northbrook, il) is a molecular method for the rapid identification of gram-positive organisms and resistance markers directly from blood culture bottles. a total of 148 versatrek redox 1 40-ml aerobic bottles demonstrating gram-positive bacteria were tested. results were compared with those from conventional biochemical and matrix-assisted laser desorption ionization-time of flight (maldi-tof) identifications. we obtained isolat ...201324048531
brain abscess in the computed tomography era: a 10-year experience from auckland, new zealand.notes were reviewed for 68 patients with brain abscess diagnosed at auckland hospital, auckland, new zealand between 1978 and 1988. mean age was 30 years (range one week to 74 years). there were 48 men and 40% were maori or pacific island polynesians. seventy-two per cent of patients had headache, 54% had fever and 72% had lateralizing neurological signs. thirty-one per cent of abscesses were associated with contiguous infection (otic, sinus, dental). forty-four per cent were in the frontal lobe ...199322346451
intrathecal granuloma and intramedullary abscess associated with an intrathecal morphine pump.objective and importance. several previous reports have documented cord compression resulting from the formation of an intrathecal inflammatory mass in patients using intrathecal drug delivery systems. we present the first reported case of an intramedullary abscess and intrathecal inflammatory mass associated with an intrathecal drug delivery system. clinical presentation. a 47-year-old man was transferred to our institution from an outside hospital with a 3-week history of the inability to am ...200722151806
rapid detection of gram-positive organisms by use of the verigene gram-positive blood culture nucleic acid test and the bact/alert pediatric fan system in a multicenter pediatric evaluation.assays that expedite the reporting of organism identification and antibiotic susceptibility status in positive blood cultures can fast track interventions that improve clinical outcomes. we evaluated the verigene gram-positive blood culture nucleic acid test (bc-gp) in two pediatric hospitals. positive bact/alert pediatric fan blood cultures with gram-positive organisms were tested using the bc-gp in tandem with routine laboratory procedures. to test organisms underrepresented in the clinical bl ...201323966484
organization of the capsule biosynthesis gene locus of the oral streptococcus streptococcus anginosus.the capsular polysaccharide (cps) of the important oral streptococcus streptococcus anginosus, which causes endocarditis, and the genes for its synthesis have not been clarified. in this study, we investigated the gene locus required for cps synthesis in s. anginosus. southern hybridization using the cpse gene of the well-characterized bacterium s. agalactiae revealed that there is a similar gene in the genome of s. anginosus. by using the colony hybridization technique and inverse pcr, we isola ...201122100898
dental abscess: a microbiological review.dental abscess is a frequently occurring infectious process known to the health practice. the fate of the infection depends on the virulence of the bacteria, host resistance factors, and regional anatomy. serious consequences arising from the spread of a dental abscess lead to significant morbidity and mortality. acute dental abscess is polymicrobial, comprising of strict anaerobes, such as anaerobic cocci, prevotella, fusobacterium species, and facultative anaerobes, such as viridans group stre ...201324348613
[analysis of predominant bacterial species and clinical backgrounds in lung abscess patients].we reviewed the clinicopathological characteristics of lung abscesses retrospectively. we analyzed 89 patients hospitalized from july 1984 to may 2009. most were men (76/89). there were large proportions with alcohol consumption (29.2%) and dental caries or gingivitis (60.7%). furthermore, those without other diseases accounted for only 13.5%. predominant infectious species were clear in 43 cases (48.3%) including identification of bacteria. the identification rate of predominant bacteria improv ...201122073605
quantitative proteomics reveal distinct protein regulations caused by aggregatibacter actinomycetemcomitans within subgingival biofilms.periodontitis is an infectious disease that causes the inflammatory destruction of the tooth-supporting (periodontal) tissues, caused by polymicrobial biofilm communities growing on the tooth surface. aggressive periodontitis is strongly associated with the presence of aggregatibacter actinomycetemcomitans in the subgingival biofilms. nevertheless, whether and how a. actinomycetemcomitans orchestrates molecular changes within the biofilm is unclear. the aim of this work was to decipher the inter ...201525756960
establishment of an oral infection model resembling the periodontal pocket in a perfusion bioreactor system.periodontal infection involves a complex interplay between oral biofilms, gingival tissues and cells of the immune system in a dynamic microenvironment. a humanized in vitro model that reduces the need for experimental animal models, while recapitulating key biological events in a periodontal pocket, would constitute a technical advancement in the study of periodontal disease. the aim of this study was to use a dynamic perfusion bioreactor in order to develop a gingival epithelial-fibroblast-mon ...201525587671
[a young man with mononucleosis and swelling of the right eye].treatment of acute infections in the upper airways comprises a significant part of direct healthcare expenditure and is a challenge for healthcare professionals. in norway, 11,495 hospitalized days were recorded for acute infections (influenza and pneumonia excluded) in the upper airways in 2008. acute bacterial rhinosinusitis (abrs) is defined as inflammation of the nose and the paranasal sinuses characterized by both 1): symptoms of nasal blockage/obstruction/congestion or nasal discharge, and ...201121233887
microbial diversity in the early in vivo-formed dental biofilm.although the mature dental biofilm composition is well studied, there is very little information on the earliest phase of in vivo tooth colonization. progress in dental biofilm collection methodologies and techniques of large-scale microbial identification have made new studies in this field of oral biology feasible. the aim of this study was to characterize the temporal changes and diversity of the cultivable and noncultivable microbes in the early dental biofilm. samples of early dental biofil ...201626746720
competence for genetic transformation in streptococcus pneumoniae: mutations in σa bypass the comw requirement.competence for genetic transformation in the genus streptococcus depends on an alternative sigma factor, σ(x), for coordinated synthesis of 23 proteins, which together establish the x state by permitting lysis of incompetent streptococci, uptake of dna fragments, and integration of strands of that dna into the resident genome. initiation of transient accumulation of high levels of σ(x) is coordinated between cells by transcription factors linked to peptide pheromone signals. in streptococcus pne ...201425112479
[bacteria isolated from surgical infections and its susceptibilities to antimicrobial agents--special references to bacteria isolated between april 2010 and march 2011].bacteria isolated from surgical infections during the period from april 2010 to march 2011 were investigated in a multicenter study in japan, and the following results were obtained. in this series, 631 strains including 25 strains of candida spp. were isolated from 170 (81.7%) of 208 patients with surgical infections. four hundred and twenty two strains were isolated from primary infections, and 184 strains were isolated from surgical site infection. from primary infections, anaerobic gram-nega ...201425549405
microbiological analysis of a prospective, randomized, double-blind trial comparing moxifloxacin and clindamycin in the treatment of odontogenic infiltrates and abscesses.the objective of this study was to identify the oral pathogens found in odontogenic infections, to determine their susceptibilities to amoxicillin-clavulanic acid (amc), clindamycin (cli), doxycycline (dox), levofloxacin (lvx), moxifloxacin (mxf), and penicillin (pen), and to search for associations between specific pathogens and types of infection. swabs from patients enrolled in a randomized, double-blind phase ii trial comparing mxf with cli for the treatment of odontogenic abscesses or infla ...201222354306
unusual mammary abscess. 201121444940
validation of antibiotic efficacy on in vitro subgingival biofilms.systemic antibiotics are often used as adjunctive treatment modalities for periodontal diseases. testing of antimicrobial efficacy can be relevant only if the bacteria are in the form of biofilms rather than the planktonic state, and at concentrations of physiologic relevance, i.e., reachable in the periodontal pocket. the aim of the present study is to test the antimicrobial efficacy of five common antibiotic schemes at physiologically relevant concentrations on a multispecies in vitro biofilm ...201423659420
microarray analysis of microbiota of gingival lesions in noma patients.noma (cancrum oris) is a gangrenous disease of unknown etiology affecting the maxillo-facial region of young children in extremely limited resource countries. in an attempt to better understand the microbiological events occurring during this disease, we used phylogenetic and low-density microarrays targeting the 16s rrna gene to characterize the gingival flora of acute noma and acute necrotizing gingivitis (ang) lesions, and compared them to healthy control subjects of the same geographical and ...201324086784
antibiotic effects on bacterial profile in osteonecrosis of the jaw.oral diseases (2011) 18, 85-95 objective:  oral infection is considered to play a critical role in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (bronj), and antibiotic therapy has become a mainstay of bronj therapy. this study was aimed to investigate the effect of antibiotics on bacterial diversity in bronj tissues. materials and methods:  the bacterial profile from soft tissues associated with the bronj lesion was determined using 16s rrna-based denaturing gradient gel e ...201221883710
tunel analysis of dna fragmentation in mouse unfertilized oocytes: the effect of microorganisms within human follicular fluid collected during ivf cycles.recently we reported the presence of bacteria within follicular fluid. previous studies have reported that dna fragmentation in human spermatozoa after in vivo or in vitro incubation with bacteria results in early embryo demise and a reduced rate of ongoing pregnancy, but the effect of bacteria on oocytes is unknown. this study examined the dna within mouse oocytes after 12 hours' incubation within human follicular fluids (n=5), which were collected from women undergoing in vitro fertilization ( ...201323972717
microbiology and choice of antimicrobial therapy for acute sinusitis complicated by subperiosteal abscess in children.review past studies of the microbiology of subperiosteal abscesses (spoa) complicating sinusitis in children and their implications of the antimicrobials administered to treat the infection.201627063747
critical role of tedizolid in the treatment of acute bacterial skin and skin structure infections.tedizolid phosphate has high activity against the gram-positive microorganisms mainly involved in acute bacterial skin and skin structure infections, such as strains of staphylococcus aureus (including methicillin-resistant s. aureus strains and methicillin-sensitive s. aureus strains), streptococcus pyogenes, streptococcus agalactiae, the streptococcus anginosus group, and enterococcus faecalis, including those with some mechanism of resistance limiting the use of linezolid. the area under the ...201728053508
activities of tedizolid and linezolid determined by the reference broth microdilution method against 3,032 gram-positive bacterial isolates collected in asia-pacific, eastern europe, and latin american countries in 2014.tedizolid and linezolid in vitro activities against 3,032 gram-positive pathogens collected in asia-pacific, eastern european, and latin american medical centers during 2014 were assessed. the isolates were tested for susceptibility by the current reference broth microdilution methods. due to concern over the effect of mic endpoint criteria on the results of testing the oxazolidinones tedizolid and linezolid, mic endpoint values were read by two methods: (i) reading the mic at the first well whe ...201627353270
telavancin: mechanisms of action, in vitro activity, and mechanisms of resistance.telavancin is a semisynthetic lipoglycopeptide derivative of vancomycin. telavancin has a dual mechanism of antibacterial action, disrupting peptidoglycan synthesis and cell membrane function. in 2014, the clinical and laboratory standards institute (clsi) revised the antimicrobial susceptibility testing method for telavancin, resulting in minimum inhibitory concentration (mic) determinations that are more accurate and reproducible and demonstrate greater in vitro potency than shown with the pre ...201526316559
in vitro activities of tedizolid and linezolid against gram-positive cocci associated with acute bacterial skin and skin structure infections and pneumonia.tedizolid is a novel, expanded-spectrum oxazolidinone with potent activity against a wide range of gram-positive pathogens. a total of 425 isolates of gram-positive bacteria were obtained consecutively from patients with acute bacterial skin and skin structure infections (absssis) or pneumonia. these isolates included methicillin-susceptible staphylococcus aureus (mssa) (n = 100), methicillin-resistant staphylococcus aureus (mrsa) (n = 100), streptococcus pyogenes (n = 50), streptococcus agalact ...201526248355
activity of oritavancin against gram-positive clinical isolates responsible for documented skin and soft-tissue infections in european and us hospitals (2010-13).to assess oritavancin activity in vitro against clinically relevant gram-positive pathogens causing skin and soft-tissue infections (sstis) in european and us hospitals.201525362568
vang element insertions within a conserved chromosomal site conferring vancomycin resistance to streptococcus agalactiae and streptococcus anginosus.three vancomycin-resistant streptococcal strains carrying vang elements (two invasive streptococcus agalactiae isolates [gbs-ny and gbs-nm, both serotype ii and multilocus sequence type 22] and one streptococcus anginosus [sa]) were examined. the 45,585-bp elements found within sa and gbs-ny were nearly identical (together designated vang-1) and shared near-identity over an ~15-kb overlap with a previously described vang element from enterococcus faecalis. unexpectedly, vang-1 shared much less h ...201425053786
man with shoulder pain after a fall. necrotizing fasciitis. 201122098998
urgent splenectomy in the course of prosthetic valve endocarditis.we present a case of a 51-year-old male patient hospitalized due to acute coronary syndrome requiring stent implantation to the left main stem. double antiplatelet therapy was commenced. after 2-3 days, the patient presented with high fever, dyspnea on exertion, pain in the chest, myalgia, and general weakness. transthoracic (tte) and transesophageal (tee) echocardiography revealed abnormal, turbulent flow across the aortic prosthesis, which was probably caused by the presence of a pathological ...201426336422
[Abscess in the spleen in a 28 year-old, previously healthy man].A 28 year-old, previously healthy man was hospitalised with acute abdominal pain and a high fever. During six months the patient had suffered from severe pain in his left shoulder, left part of the thorax and over time also in the upper part of the abdomen. When hospitalised he showed biochemical signs of infection and a computer tomography of the abdomen revealed an 11 cm abscess in the spleen. Non-haemolytic streptococci were found after aspiration. Initially the abscess was treated with antib ...201122118655
prevalence of β-hemolytic groups c and f streptococci in patients with acute pharyngitis.the roles of group c and f streptococci in causing endemic pharyngitis are still controversial, although group c streptococci are implicated in the outbreaks of pharyngitis and associated disorders.201122540078
identification of anion channels responsible for fluoride resistance in oral streptococci.recently, it has been reported that eric and crcb are involved in bacterial fluoride resistance. however, the fluoride-resistance mechanism in oral streptococci remains unclear. blast studies showed that two types of erics (eric1 and eric2) and two types of crcbs (crcb1 and crcb2) are present across 18 oral streptococci, which were identified in ≥ 10% of 166 orally healthy subjects with ≥ 0.01% of the mean relative abundance. they were divided into three groups based on the distribution of these ...201627824896
neurosurgical management of extraaxial central nervous system infections in children.object extraaxial infections of the cns, including subdural empyema and epidural abscess, are rare but potentially life-threatening conditions. symptoms are usually progressive, and early diagnosis is therefore important. early intervention with appropriate treatment offers the best opportunity for eradicating the infection and promoting maximal neurological recovery. methods the medical records of children with extraaxial cns infection over the last 24 years at the hospital for sick children we ...201121529183
the role of bacteria in oral cancer.despite the widening interest in the possible association between bacteria and different stages of cancer development, our knowledge in its relation to oral cancers remains inadequate. the aim of this review article is to derive a better understanding on the role of various micro-organisms in the etiogenesis of oral cancers through all the available data on the pubmed. different bacteria have been proposed to induce carcinogenesis either through induction of chronic inflammation or by interferen ...201021584217
streptococcus constellatus bacteremia causing septic shock following tooth extraction: a case report.organisms of the streptococcus milleri group consists of streptococcus intermedius, streptococcus constellatus, and streptococcus anginosus. though they are commonly associated with abscesses, bacteremia with subsequent septic shock and mortality is infrequent.200919829816
concurrent postpartum uterine and abdominal wall dehiscence and streptococcus anginosus infection.: postpartum uterine scar dehiscence is a rare but potentially lethal complication of cesarean deliveries.201121768850
impact of early colonizers on in vitro subgingival biofilm formation.the aim of this study was to investigate the impact of early colonizing species on the structure and the composition of the bacterial community developing in a subgingival 10-species biofilm model system. the model included streptococcus oralis, streptococcus anginosus, actinomycesoris, fusobacterium nucleatum subsp. nucleatum, veillonella dispar, campylobacter rectus, prevotella intermedia, porphyromonas gingivalis, tannerella forsythia, and treponema denticola. based on literature, we consider ...201324340084
congenital alterations of nemo glutamic acid 223 result in hypohidrotic ectodermal dysplasia and immunodeficiency with normal serum igg levels.hypomorphic mutations in the nuclear factor-+¦b (nf-+¦b) essential modulator (nemo) gene result in a variable syndrome of somatic and immunologic abnormalities. clinically relevant genotype-phenotype associations are essential to understanding this complex disease.201121704885
stent hypersensitivity and infection in sinus cavities.persistent mucosal inflammation, granulation tissue formation, hypersensitivity, and multifactorial infection are newly described complications of retained drug-eluting stents from endoscopic sinus surgery for refractory rhinosinusitis. in an important report published in allergy and rhinology, a 45-year-old male patient suffering from recalcitrant chronic rhinosinusitis underwent functional endoscopic sinus surgery and was found, for the first time, to have steroid-eluting catheters that were i ...201324498522
cytokine and microbial profiles in relation to the clinical outcome following treatment of peri-implantitis.to study whether cytokine levels and bacterial counts in p atients with peri-implantitis reflect clinical treatment outcome following non-surgical management.201627422156
the predominant bacteria isolated from radicular cysts.to detect predominant bacteria associated with radicular cysts and discuss in light of the literature.201324011184
[isolation and identification of aerobic and facultative anaerobic bacteria in the oral cavity].to establish a systematic method for isolation and identification of aerobic and facultative anaerobic bacteria in the oral cavity.201526714902
microbial dynamics during conversion from supragingival to subgingival biofilms in an in vitro model.the development of dental caries and periodontal diseases result from distinct shifts in the microbiota of the tooth-associated biofilm. this in vitro study aimed to investigate changes in biofilm composition and structure, during the shift from a 'supragingival' aerobic profile to a 'subgingival' anaerobic profile. biofilms consisting of actinomyces oris, candida albicans, fusobacterium nucleatum, streptococcus oralis, streptococcus mutans and veillonella dispar were aerobically grown in saliva ...201626033167
colonisation of gingival epithelia by subgingival biofilms in vitro: role of "red complex" bacteria.biofilm formation on tooth surface results in colonisation and invasion of the juxtaposed gingival tissue, eliciting strong inflammatory responses that lead to periodontal disease. this in vitro study investigated the colonisation of human gingival multi-layered epithelium by multi-species subgingival biofilms, and evaluated the relative effects of the "red complex" species (porphyromonas gingivalis, tannerella forsythia and treponema denticola).201424949828
antimicrobial, antitumor and brine shrimp lethality assay of ranunculus arvensis l. extracts.to investigate the antitumor activity, brine shrimp lethality assay, antibacterial and antifungal activity of methanol extract (me), water extract (we), acetone extract (ae), chloroform extract (ce), methanol-water extract (mwe), methanol-acetone extract (mae), methanol-chloroform extract (mce) of ranunculus arvensis (l.). antitumor activity was evaluated with agrobacterium tumefaciens (at10) induced potato disc assay. cytotoxicity was evaluated with brine shrimp lethality assay. antibacterial a ...201526004705
[analysis of diversity of vaginal microbiota in healthy chinese women by using dna-fingerprinting].to analyze the diversity of healthy women's vaginal dominant flora in different physiological states with pcr-denaturing gradient gel electrophoresis (pcr-dgge), to establish the basis for the future study of lower genital tract infections, and to provide a theoretical basis for the development of vaginal probiotics adapted to chinese females.201222517004
quantification of pseudomonas aeruginosa in multispecies biofilms using pma-qpcr.multispecies biofilms are an important healthcare problem and may lead to persistent infections. these infections are difficult to treat, as cells in a biofilm are highly resistant to antimicrobial agents. while increasingly being recognized as important, the properties of multispecies biofilms remain poorly studied. in order to do so, the quantification of the individual species is needed. the current cultivation-based approaches can lead to an underestimation of the actual cell number and are ...201525755923
subgingival microflora in inflammatory bowel disease patients with untreated periodontitis.to analyze the subgingival microflora composition of inflammatory bowel disease (ibd) patients with untreated chronic periodontitis and compare them with systemically healthy controls also having untreated chronic periodontitis.201323060013
antimicrobial activity of preparation bioaron c.the antimicrobial activity of sirupus bioaron c, a preparation, whose main ingredient is an extract from the leaves of aloe arborescens, was tested against different microorganisms isolated from patients with upper respiratory tract infections. the experiments were performed on 40 strains: 20 strains of anaerobic bacteria, 13 strains of aerobic bacteria and 7 strains of yeast-like fungi from the genus candida and on 18 reference strains (atcc). the antimicrobial activity of bioaron c (mbc and mf ...201425362808
polymicrobial purulent pericarditis probably caused by a broncho-lymph node-pericardial fistula in a patient with tuberculous lymphadenitis.purulent pericarditis is a rare condition with a high mortality rate. we report a case of purulent pericarditis subsequently caused by candida parapsilosis, peptostreptococcus asaccharolyticus, streptococcus anginosus, staphylococcus aureus, prevotella oralis, and mycobacterium tuberculosis in a previously healthy 17-year-old boy with mediastinal tuberculous lymphadenitis. the probable route of infection was a bronchomediastinal lymph node-pericardial fistula. the patient improved with antibioti ...201526788411
draft genome sequence of streptococcus anginosus bvi, a new vaginal pathogen candidate.streptococcus anginosus is a pathogen implicated in urogenital and gastroinstestinal tract infections. here, we report the draft genome sequence of s. anginosus bvi, isolated from a bacterial vaginosis patient attending a prenatal care unit in cali, colombia. the genome sequence of bvi consists of 2,014,025 bp, encoding 2,008 predicted proteins.201627979955
late aortic silver graft re-infection due to streptococcus milleri group (streptococcus anginosus). case report and literature review. 201727883162
case-control study of pneumonia patients with streptococcus anginosus group bacteria in their sputum.in recent years, streptococcus anginosus group (sag) bacteria are becoming increasingly recognized as important pneumonia-causing pathogens. although several small studies have been reported, the features of sag pneumonia remain unclear, because the identification of sag from sputum cultures is not routinely performed in most microbiology laboratories. the aim of this study was to elucidate the clinical characteristics of sag pneumonia.201627681235
impressive performance: new disposable digital ureteroscope allows for extreme lower pole access and use of 365 μm holmium laser fiber.since the development of the first flexible ureteroscope, in 1964, technological advances in image quality, flexibility, and deflection have led to the development of the first single-use digital flexible ureteroscope, lithovue™ (boston scientific, marlborough, ma). with respect to reusable fiber-optic and now digital ureteroscopes, there is an initial capital cost of several thousand dollars (usd) as well as, controversy regarding durability, the cost of repairs and the burdensome reprocessing ...201627579436
effect of smokeless tobacco products on human oral bacteria growth and viability.to evaluate the toxicity of smokeless tobacco products (stps) on oral bacteria, seven smokeless tobacco aqueous extracts (staes) from major brands of stps and three tobacco-specific n-nitrosamines (tsnas) were used in a growth and viability test against 38 oral bacterial species or subspecies. all seven staes showed concentration-dependent effects on the growth and viability of tested oral bacteria under anaerobic culture conditions, although there were strain-to-strain variations. in the presen ...201627756619
the importance of obligate anaerobes and the streptococcus anginosus group in pulmonary abscess: a clone library analysis using bronchoalveolar lavage fluid.appropriate antibiotic use reduces the mortality of patients with lung abscess; however, 40-60% of the bacterial etiologies in these patients have remained unknown with the culture methods. obligate anaerobes and the streptococcus anginosus group are common pathogens in lung abscess, but a precise evaluation of these bacteria by ordinary culture methods seems to be difficult due to upper respiratory tract contamination.201627548533
[atrio-oesophageal fistula after thoracoscopic treatment of atrial fibrillation].an atrio-oesophageal fistula (aof) is a rare but severe complication of radiofrequency ablation during video-assisted thoracoscopic pulmonary vein isolation (vats-pvi).201627438399
role of bacteria in oral carcinogenesis.oral cancer is the most common cancer diagnosed in indian men and is the leading cause of cancer deaths. it is considered as a multistep and multifactorial disease. besides accumulation of genetic mutations, numerous other carcinogens are involved. in this category, viral and chemical carcinogens are well studied and documented. however, in the oral cavity, the role of microbiota in carcinogenesis is not known. microbial populations on mouth mucosa differ between healthy and malignant sites, and ...201224455519
betel nut chewing, oral premalignant lesions, and the oral microbiome.oral cancers are attributed to a number of causal agents including tobacco, alcohol, human papillomavirus (hpv), and areca (betel) nut. although betel nut chewing has been established as an independent cause of oral cancer, the mechanisms of carcinogenesis are poorly understood. an investigation was undertaken to evaluate the influence of betel nut chewing on the oral microbiome and oral premalignant lesions. study participants were recruited from a dental clinic in guam. structured interviews a ...201728225785
leveraging sequence-based faecal microbial community survey data to identify a composite biomarker for colorectal cancer.colorectal cancer (crc) is the second leading cause of cancer-associated mortality in the usa. the faecal microbiome may provide non-invasive biomarkers of crc and indicate transition in the adenoma-carcinoma sequence. re-analysing raw sequence and metadata from several studies uniformly, we sought to identify a composite and generalisable microbial marker for crc.201728341746
assessing the use of quantitative light-induced fluorescence-digital as a clinical plaque assessment.the aims of this study were to compare the relationship between red fluorescent plaque (rf plaque) area by quantitative light-induced fluorescence-digital (qlf-d) and disclosed plaque area by two-tone disclosure, and to assess the bacterial composition of the rf plaque by real time-pcr.201626691322
pantoea agglomerans in immunodeficient patients with different respiratory symptoms.the aim of this paper was to determine in 32 patients from 4 different mexican hospitals the frequency of opportunistic bacteria in the 2010 to 2011 time period. the patients were divided in 4 groups. group 1 included 21 hiv positive patients with acute respiratory syndrome. four hiv positive patients with tuberculosis symptoms were included in group 2; two patients with tuberculosis symptoms and one asymptomatic person formed group 3. reference group 4 included 4 patients from whom 4 strains of ...201222619600
modulation of behaviour and virulence of a high alginate expressing pseudomonas aeruginosa strain from cystic fibrosis by oral commensal bacterium streptococcus anginosus.cystic fibrosis (cf) airways harbour complex and dynamic polymicrobial communities that include many oral bacteria. despite increased knowledge of cf airway microbiomes the interaction between established cf pathogens and other resident microbes and resulting impact on disease progression is poorly understood. previous studies have demonstrated that oral commensal streptococci of the anginosus group (ags) can establish chronic pulmonary infections and become numerically dominant in cf sputa indi ...201728301571
64-year-old male with septic arthritis of the pubic symphysis.septic arthritis of the pubic symphysis is a rare disease. typical clinical features include fever, pubic or groin pain, pain with hip motion, and painful or waddling gait. identified predisposing factors to develop an infection in pubic joint include female incontinence surgery or postpartum period; sports, especially soccer; pelvic malignancy; and intravenous drug abuse. the most often identified microorganisms were staphylococcus aureus and pseudomonas aeruginosa. osteomyelitis complicates th ...201124765337
pediatric nasal orbital cellulitis in shenzhen (south china): etiology, management, and outcomes.the study aimed to investigate the clinical characteristics, diagnosis, and treatment of orbital cellulitis in children in shenzhen, china, and to improve the experience of antibiotic therapy for the treatment of orbital cellulites.201627368452
solitary pyomyositis of the left rhomboideus muscle caused by streptococcus anginosus and streptococcus intermedius in an immunocompetent person.primary pyomyositis is a bacterial infection of the skeletal muscle commonly affecting children with staphylococcus aureus most often isolated as a pathogen. however, pyomyositis caused by anaerobic bacteria is rare in adults. here, we report a case of solitary pyomyositis of the left rhomboideus muscle in an immunocompetent person. a 70-year-old japanese male presented with high fever and left shoulder pain. his muscle below the lower edge of the left scapula was tender and swollen. his laborat ...201526185692
surrogate analysis of vancomycin to predict susceptible categorization of dalbavancin.dalbavancin (dal) represents a recently approved addition for the treatment of acute bacterial skin and skin structure infections (absssis). newly released antimicrobial agents are rarely found on commercial susceptibility testing devices, and surrogate testing may be an option for clinical microbiology laboratories. a total of 33,688 staphylococcus aureus, 2800 viridans group streptococci (vgs), and 5722 β-hemolytic streptococci (bhs) were included in this cross-susceptibility (dal versus vanco ...201525724854
chromosomal islands of streptococcus pyogenes and related streptococci: molecular switches for survival and virulence.streptococcus pyogenes is a significant pathogen of humans, annually causing over 700,000,000 infections and 500,000 deaths. virulence in s. pyogenes is closely linked to mobile genetic elements like phages and chromosomal islands (ci). s. pyogenes phage-like chromosomal islands (spyci) confer a complex mutator phenotype on their host. spyci integrate into the 5' end of dna mismatch repair (mmr) gene mutl, which also disrupts downstream operon genes lmrp, ruva, and tag. during early logarithmic ...201425161960
microbial causes of complicated acute bacterial rhinosinusitis and implications for empirical antimicrobial therapy.very little up-to-date information is available on the microbiology of complicated acute bacterial rhinosinusitis. reliable microbiology testing is necessary to inform current empirical antimicrobial treatments. this study was conducted in response to recent us guidelines on antimicrobial treatments for acute bacterial rhinosinusitis. it aimed to describe the pathological micro-organisms involved in complicated acute bacterial rhinosinusitis in the uk and their antimicrobial susceptibility.201626678822
cavernosal abscess due to streptococcus anginosus: a case report and comprehensive review of the literature.corpus cavernosum abscesses are uncommon with only 23 prior reports in the literature. several precipitating factors for cavernosal infections have been described including injection therapy for erectile dysfunction, trauma, and priapism. common causal organisms include staphylococcus aureus, streptococci, and bacteroides. we report a unique case of a corpus cavernosum abscess due to proctitis with hematological seeding and review the literature on cavernosal abscesses.201324917758
periocular necrotizing fasciitis causing blindness.periocular necrotizing fasciitis is a rare but potentially devastating disease, accompanied by high rates of morbidity and mortality.201323868053
spontaneous septic arthritis of the pubic symphysis in an afebrile patient.septic arthritis is a rare infection usually involving the knee or hip but can infrequently affect less obvious joints such as the pubic symphysis.risk factors for septic arthritis include joint repair or replacement surgery, systemic infection, intravenous recreational drug use, and alcoholism.we present the case of a 48-year-old man with a final diagnosis of septic arthritis of the pubic symphysis who had no risk factors besides alcoholism. the presentation was unusual in that the patient was ...201626475359
lincosamide resistance mediated by lnu(c) (l phenotype) in a streptococcus anginosus clinical isolate.unique resistance to lincosamides (l phenotype) due to the production of nucleotidyltransferases (lnu) is uncommon among gram-positive bacteria. the aim of the study was to characterize the l phenotype in a clinical isolate of the streptococcus milleri group.201323812683
correction for zuñiga-bahamon et al., draft genome sequence of streptococcus anginosus bvi, a new vaginal pathogen candidate. 201728280015
members of a new subgroup of streptococcus anginosus harbor virulence related genes previously observed in streptococcus pyogenes.conventionally categorized as commensals, the streptococci of the species s. anginosus are facultative human pathogens that are difficult to diagnose and often overlooked. furthermore, detailed investigation and diagnosis of s. anginosus infections is hampered by unexplored taxonomy and widely elusive molecular pathogenesis. to explore their pathogenic potential, s. anginosus isolates collected from patients of two geographical locations (vellore, india and leipzig, germany) were subjected to mu ...201728274699
[streptococcus milleri: an unusual cause of skull extensive osteomyelitis in an immunocompetent patient].streptococcus milleri (streptococcus anginosus, intermedius and constellatus) are commensal organisms, which can become pathogenic and cause infection with frequent abscess formation, local or metastatic extension. osteomyelitis of the skull has been rarely reported in this type of infection.201728236536
the sil locus in streptococcus anginosus group: interspecies competition and a hotspot of genetic diversity.the streptococcus invasion locus (sil) was first described in streptococcus pyogenes and streptococcus pneumoniae, where it has been implicated in virulence. the two-component peptide signaling system consists of the sila response regulator and silb histidine kinase along with the silcr signaling peptide and sild/e export/processing proteins. the presence of an associated bacteriocin region suggests this system may play a role in competitive interactions with other microbes. comparative analysis ...201628119678
colorectal cancer associated with streptococcus anginosus bacteremia and liver abscesses.streptococcus anginosus is part of the normal flora of the human gastrointestinal tract. their ability to cause abscesses is very unique and sets them apart from the rest of the streptococci groups. while an association of group d streptococcus bacteremia and endocarditis with colorectal carcinoma is well established, s. anginosus infections are rarely implicated with colonic malignancy. we present a case of a 62-year-old male who presented to the hospital with fatigue and generalized abdominal ...201728100999
septic arthritis of an atlantoaxial facet joint with normal inflammatory markers: case report and literature review.septic arthritis of the atlantoaxial facet joint is extremely rare. contiguous spread to the median atlantoaxial joints with subsequent dens erosion can lead to atlantoaxial instability. misleading normal inflammatory markers can result in delayed diagnosis and catastrophic consequences.201727993739
comparative genome analysis of the daptomycin-resistant streptococcus anginosus strain j4206 associated with breakthrough bacteremia.streptococcus anginosus is a member of the normal oral flora that can become a pathogen causing pyogenic infections in humans. the genome of daptomycin-resistant strain j4206, originally isolated from a patient suffering from breakthrough bacteremia and septic shock at the university of texas health science center at san antonio, was determined. the circular genome is 2,001,352 bp long with a gc content of 38.62% and contains multiple mobile genetic elements, including the phage-like chromosomal ...201627678123
intra-abdominal abscess and primary peritonitis caused by streptococcus anginosus.the streptococcus anginosus group of bacteria are low-virulence bacteria existing as commensals in the oral flora and gastrointestinal tracts of humans. s. anginosus may spread to the blood in individuals with poor oral hygiene in cases of oral infections, such as gingivitis and tooth abscesses, that develop following the loss of mucosal unity. this may lead to infections in the whole body, primarily as brain and liver abscesses.201627630763
machine learning meta-analysis of large metagenomic datasets: tools and biological insights.shotgun metagenomic analysis of the human associated microbiome provides a rich set of microbial features for prediction and biomarker discovery in the context of human diseases and health conditions. however, the use of such high-resolution microbial features presents new challenges, and validated computational tools for learning tasks are lacking. moreover, classification rules have scarcely been validated in independent studies, posing questions about the generality and generalization of dise ...201627400279
molecular characterization and antibiotic resistance of group g streptococci in israel: comparison of invasive, non-invasive and carriage isolates.beta-hemolytic group g streptococci (ggs) are increasingly recognized as a source of substantial morbidity, causing mild to severe sporadic infections as well as outbreaks. the purpose of this study was to determine the genetic diversity and antibiotic resistance of ggs in israel in order to aid in prevention and control. a total of 325 ggs isolates were collected in israel between 2007 and 2011 from three determined settings: (1) carriage (n = 60), an observational longitudinal carriage study i ...201627325440
a reference broth microdilution method for dalbavancin in vitro susceptibility testing of bacteria that grow aerobically.antimicrobial susceptibility testing (ast) is performed to assess the in vitro activity of antimicrobial agents against various bacteria. the ast results, which are expressed as minimum inhibitory concentrations (mics) are used in research for antimicrobial development and monitoring of resistance development and in the clinical setting for antimicrobial therapy guidance. dalbavancin is a semi-synthetic lipoglycopeptide antimicrobial agent that was approved in may 2014 by the food and drug admin ...201526381422
[management of nasal orbital cellulitis in children].to analyze the clinical characteristics, diagnostic and treatment principle of orbital cellulitis in children, and to improve the experience of antibiotic treatment in orbital cellulites.201525764921
characteristics of superior orbital subperiosteal abscesses in children.superior pediatric orbital subperiosteal abscesses (spas) are less common than medial ones, and clinical features specific to patients with superior spas have not been well defined. clinical characteristics between patients with superior and medial spas are compared to determine whether superior location is a risk factor for surgical intervention.201727291943
cervical necrotizing fasciitis: descriptive, retrospective analysis of 59 cases treated at a single center.to provide retrospective, descriptive information on patients with cervical necrotizing fasciitis treated at a single center during the years 1998-2014, and to evaluate the outcome of a newly introduced treatment strategy. retrospective analysis of clinical data obtained from medical records. mortality, pre-morbidity, severity of illness, primary site of infection, type of bacteria, time parameters. the observed 3-month mortality was 6/59 (10 %). the most common initial foci of the infection wer ...201627287509
streptococcus anginosus (milleri) group strains isolated in poland (1996-2012) and their antibiotic resistance patterns.streptococcus anginosus, streptococcus intermedius and streptococcus constellatus form a group of related streptococcal species, namely the streptococcus anginosus group (sag). the group, previously called "milleri" had been rarely described until 1980/1990 as source of infections. nowadays sag bacteria are often described as pathogens causing predominantly purulent infections. the number of infections is highly underestimated, as sag strains are often classified in the microbiology laboratory a ...201627281992
bloodstream infections caused by streptococcus anginosus group bacteria: a retrospective analysis of 78 cases at a japanese tertiary hospital.to investigate the characteristics of streptococcus anginosus group (sag) bacteremia in recent years, we conducted a retrospective cohort study and compared its findings with the data from previous studies.201627142978
the streptococcus milleri group in chronic obstructive pulmonary disease.s. anginosus, constellatus and intermedius, also known as the streptococcus milleri group (smg) are three streptococcal species more frequently detected in cases of invasive disease, abscesses and empyema in particular. recent research suggests they play a role in exacerbations of cystic fibrosis (cf). owing to poor recovery on standard culture media and difficult differentiation from non-pathogenic streptococci, smg may be underdiagnosed in routine settings. we aimed to establish the incidence ...201627132809
infection necrosis after an extracorporeal reduction of a condyle fracture.the authors experienced a patient of infection necrosis after an extracorporeal reduction of a condyle fracture and reconstructed it with an iliac bone graft.a 37-year-old man visited with a bilateral condyle fracture and a left para-symphyseal fracture. on the post-trauma third day, an intermaxillary fixation was applied using arch bars. on the post-trauma tenth day, an extracorporeal reduction was carried out. on postoperative day (pod) 7, the amount of the drain was 9 cc and the drain was rem ...201627054427
multiple brain abscesses due to streptococcus anginosus: prediction of mortality by an imaging severity index score.an elderly patient with altered mental status, brain abscesses, ventriculitis, and empyemas died of septic shock and brain abscesses secondary to streptococcus anginosus despite aggressive treatment. an imaging severity index score with a better prognostic value than the glasgow coma scale predicted mortality in this patient.201627034878
pyogenic ventriculitis as clinical presentation of diverticulitis. 201626928780
complete genome sequence of streptococcus anginosus j4211, a clinical isolate.streptococcus anginosus is an opportunistic human pathogen that causes abscesses of the brain, liver, and other organs. here, we announce the complete genome sequence of a clinically isolated strain of s. anginosus j4211. the genome sequence contains two prophages and multiple mobile genetic elements.201526679576
ceftaroline activity tested against viridans group streptococci from us hospitals.a total of 840 clinically relevant viridans group streptococci (vgs) isolates (1/patient episode) were collected from 71 us medical centers in 2013-2014. these organisms were tested for susceptibility by reference broth microdilution methods against ceftaroline and selected comparator agents. all isolates were speciated by matrix-assisted laser desorption ionization-time-of-flight (maldi-tof) mass spectrometry and were primarily from skin/soft tissue (32.6%) and bloodstream (32.3%) infections. c ...201626658313
the clinical features of respiratory infections caused by the streptococcus anginosus group.the streptococcus anginosus group (sag) play important roles in respiratory infections. it is ordinarily difficult to distinguish them from contaminations as the causative pathogens of respiratory infections because they are often cultured in respiratory specimens. therefore, it is important to understand the clinical characteristics and laboratory findings of respiratory infections caused by the sag members. the aim of this study is to clarify the role of the sag bacteria in respiratory infecti ...201526502716
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