Publications

influence of protein and calorie deficiencies in the rat on the energy-transfer reactions of the striated muscle.		1964	4284462
transformation in bacillus subtilis. ii. the development and maintenance of the competent state.		1966	4960489
[the effect of antimetabolites on cell metabolism in warm-blooded animals].		1966	4383598
[study of the effect of anticoagulants on the kidney function].		1967	4175312
virus-induced antigen.		1967	4168708
[effect of epiphysectomy on the ovary of the golden hamster (mesocricetus auratus waterh.)].		1967	4231631
[succession in rna synthesis in fibroblasts infected with sendai virus].		1968	4298764
[succession in rna synthesis in fibroblasts infected with sendai virus].		1968	4298764
effect of polynucleotides on aminoacyl transfer ribonucleic acid synthetases. 3. inhibition of glutamyl transfer ribonucleic acid synthetase by natural polynucleotides.		1968	4299520
autologous immune complex nephritis induced with renal tubular antigen. ii. the pathogenetic mechanism.	the pathogenetic mechanism involved in a form of experimental allergic glomerulonephritis induced by immunization of rats with renal tubular antigen has been investigated. a single immunization with less than a milligram of a crude renal tubular preparation, probably containing less than 25 microg of the specific nephritogenic antigen, is effective in the induction of this form of chronic membranous glomerulonephritis. in the nephritic kidney autologous nephritogenic tubular antigen is found in ...	1968	4169966
action of cloxacillin and nafcillin on escherichia coli.		1968	4868481
specific inhibition of viral ribonucleic acid replication by gliotoxin.	gliotoxin inhibits intracellular replication of poliovirus in hela cells at a stage subsequent to adsorption and penetration of virus. the sensitive step is synthesis of viral rna: synthesis of viral protein is unaffected except as a consequence of blockade of rna synthesis. concentrations of gliotoxin sufficient to block viral rna synthesis completely do not affect cellular rna synthesis.	1968	4294481
specific inhibition of viral ribonucleic acid replication by gliotoxin.	gliotoxin inhibits intracellular replication of poliovirus in hela cells at a stage subsequent to adsorption and penetration of virus. the sensitive step is synthesis of viral rna: synthesis of viral protein is unaffected except as a consequence of blockade of rna synthesis. concentrations of gliotoxin sufficient to block viral rna synthesis completely do not affect cellular rna synthesis.	1968	4294481
biosynthesis of the pyrimidine moiety of thiamine. a new route of pyrimidine biosynthesis involving purine intermediates.	1. the pattern of distribution on the purine pathway of mutants of salmonella typhimurium lt2 that had the double growth requirement for a purine plus the pyrimidine moiety of thiamine (ath mutants) indicated that purines and the pyrimidine moiety of thiamine share the early part of their biosynthetic pathways, and that 4-aminoimidazole ribonucleotide (air) is the last common intermediate. two mutants that at first appeared anomalous were further investigated and found not to affect this deducti ...	1968	4889364
an unusual inhibitory effect of histamine: suppression of atropine-resistant tetanic spasms after mepyramine block of histamine contractions.		1969	4390876
[epidemiological analysis of japanese encephalitis. statistics collected in miyagi prefecture in the last 5 years].		1969	4390886
activation of adenyl cyclase by glucagon in cat and human heart.		1969	4303624
activation of adenyl cyclase by glucagon in cat and human heart.		1969	4303624
[gastric motility and ph during natural human sleep].		1969	4303638
[gastric motility and ph during natural human sleep].		1969	4303638
interactions between monovalent cations and the (na+ + k+)-dependent adenosine triphosphatase.		1970	4319460
[radioecological parameters of the lichen-northern deer--man chain].		1970	4249191
independence of allotypic determinants and antibody specificity.		1970	4195497
[immunoelectrophoretic examinations of the effect of whole body irradiation on the serum protein picture of juvenile rats].		1970	4101506
the influence of ischemia of the brain and transplanted kidney on fibrinolytic activity.		1970	4911951
antioxytocin activity of propranolol, inpea and their optical isomers on the isolated rat uterus.		1971	4400536
differential stimulation by parathyroid hormone of bone and kidney ribonucleic acid synthesis.		1971	5090900
[specific cell-mediated immunity in batrachians. ii. delayed hypersensitivity to bcg in the toad (bufo bufo l.)].		1972	4630832
incidence of cytomegalovirus infections in early childhood.		1972	4336585
incidence of cytomegalovirus infections in early childhood.		1972	4336585
cultural characteristics of a cell line derived from an equine sarcoid.	a cell line, derived from a spontaneous equine connective tissue tumor (equine sarcoid), has been established. the morphological and growth characteristics indicative of malignant transformation of the cells include a disoriented, rapid growth and loss of contact inhibition. further evidence of transformation is the agglutination of these cells by concanavalin a and their ability to divide in semisolid media.	1972	4640736
[susceptibility of culex pipiens molestus, forskal mosquitoes of the moscow population to wuchereria bancrofti, cobbold].		1972	4653706
beat-to-beat analysis of left ventricular pressure-volume relations in atrial fibrillation in man.		1972	5007808
tryptophan synthetase from bacillus subtilis. purification and characterization of the component.		1973	4633670
tumours of the pancreas.		1973	4377996
autoimmune hemolytic anemia in wiskott-aldrich syndrome during treatment with transfer factor.		1973	4742570
age dependent determinations of lysosomal enzyme activities in the liver and brain as well as the measurements of cytoplasmic enzyme activities in the blood of piracetam pre-treated rats.		1973	4149731
the cryopreservation of sheep erythrocyte intermediates ea nad eac4 in complement assays.		1974	4215834
effects of chlorpromazine and three metabolites on behavioral responses in rats.		1974	4812658
superficial and juxtamedullary nephron function during saline loading in the dog.	a modification of the microdissection technique of hanssen was utilized in dogs to measure superficial (sngfr) and juxtamedullary nephron filtration rate (jmgfr) in control and saline-expanded dogs. during control studies sngfr was 60+/-4 and jmgfr was 72+/-5 nl/min. during saline loading sngfr was 74+/-8 and jmgfr was 65+/-6 nl/min. the ratio sngfr: jmgfr significantly increased from 0.84+/-0.03 to 1.15+/-0.08. glomerular perfusion rate (gpr) was measured with the microsphere method during cont ...	1974	4815088
protein kinases in testes of adult and prepuberal rats.		1974	4369082
nucleotide sequences of transfer ribonucleic acids.		1974	4604833
review of the induction of cycling of erythropoietin sensitive cells by androgens and their 5 beta-h-metabolites.		1974	4611514
cell-mediated immune response in mice treated with steroidal contraceptives.	the splenomegaly assay (simonsen, 1962) was standardized using different strains of rats and mice. male wistar rat (donor)-female swiss mouse (host) was found to be the suitable combination that could be employed in subsequent experiments to study the potential of contraceptive steroids to alter cmir. the index of splenomegaly appeared to increase in case of mice treated with combination oral contraceptives (ovulen, ovral or enovid). the differences observed, however, neared significance only in ...	1975	55327
survey of helminth infections in maine dairy cattle.	the survey was done to determine the incidence and seasonal prevalence of the gastrointestinal helminths infecting maine dairy cattle. approximately equal groups of calves, heifers, and cows from 13 dairy farms, managerially and geographically representative of dairying in the state, were sampled at regular 2-month intervals over the period of a year. on the basis of fecal egg counts and identification of cultured larvae, the following results were obtained: of the 94 adult cows, 78 heifers, and ...	1975	127538
human placental lactogen concentration during physiological fluctuations of serum glucose in normal pregnant and gestational diabetic women.	oral glucose tolerance tests (ogtt) were carried out in 9 normal pregnant women and 11 non-obese gestational diabetics in late pregnancy. all samples were analysed for the content of glucose, insulin and placental lactogen hormone (hpl). furthermore, spontaneous changes in the serum hpl concentration during a 3 h period were studied in 6 normal women in the 2nd half of pregnancy. during ogtt only small and insignificant changes in the level of hpl were observed in both the normal subjects and th ...	1975	1242271
[bile and stress ulcer in the rat (author's transl)].	the influence of bile on the ulcer formation under "restraint stress" condition was studied in rats with direct choledocho-gastrostomia resp. bile duct ligation. after 9 hrs. of immobilisation in plaster cuffs the animals with unrestricted bile flow via the choledochosstress gastrostomia showed as many ulcers as the sham-operated controls. there was no difference in the ulcer localisation, the region of the bile duct anastomosis was without any ulcer. after bile duct ligation the ulcer frequency ...	1975	1214546
modulation by acetylcholine of adrenergic transmission in the rabbit ear artery.	1. low concentrations of acetylcholine (4 times 10(-11) and 1 times 10(-10) m) increase the vasoconstrictor response of the isolated ear artery of the rabbit to stimulation of the periarterial sympathetic nerves. higher concentrations (4 times 10(-8) m and greater) decrease the response. 2. low concentrations of acetylcholine (1 times 10(-11) and 1 times 10(-10) m) increase the stimulation-induced efflux of radioactivity from artery segments previously incubated with [3h]-noradrenaline. higher o ...	1975	166718
elementary particles in isolated rat liver and spleen nuclear membranes.	elementary spherical particles similar to those described in the mitochondria are found in isolated rat liver and spleen nuclear membranes. the particles are characterized by electron microscopy of sections and preparations negatively stained with phosphotungstic acid or with the atpase histochemical reaction product. the particles exhibit adenosine triphosphatase activity and have a mushroom-like shape with a sphere about 85-90 angstrom in diameter attached to inner face of the inner nuclear me ...	1975	126876
evidence for species-specific substrate-site-directed inactivation of rabbit adenylate kinase by n6-(6-iodoacetamido-n-hexyl)adenosine 5'-triphosphate.	adenosine 5'-triphosphate (atp) derivatives bearing iodoacetylamino-n-alkyl substituents [(ch2)nnhcoch2i] on n6 were synthesized as potential atp-site-directed irreversible inhibitors of adenylate kinases from rabbit, pig, and carp muscle. when n was 5 no enzyme was progressively inhibited (inactivated) by 1 mm inhibitor under the test conditions (6 h at 0 degrees); when n was 6 the rabbit enzyme was 76% inactivated by 0.79 mm inhibitor whereas the pig and carp enzymes were unaffected by 2.76 mm ...	1976	187748
[animal experiment studies on parenteral utilization of maltose].	the utilisation of parenterally administered maltose was investigated in the anaesthetized rat, and in rats fixed in metabolic cages. additionally, the metabolism of maltose was measured with the isolated perfused rat liver. during intravenous infusion of 0.3 g, 0.6 g or 1.2 g maltose (corresponding to 0.9 g, 1.8 g or 3.6 g/kg bodyweight) per hour a steady-state for maltose in blood was attained. blood glucose concentration rose during the maltose infusions. the utilisation of parenterally admin ...	1976	135420
attenuated, streptomycin-dependent salmonella typhi oral vaccine: potential deleterious effects of lyophilization.	four studies were done with streptomycin-dependent salmonella typhi as an oral, attenuated vaccine. studies 1 and 3 employed freshly harvested vaccine, whereas studies 2 and 4 involved lyophilized vaccine. five to eight doses (3 x 10(10)-10(11) organisms/dose) were given; oral streptomycin (1.0 g) was administered concomitantly in studies 2 and 3, with only two of the doses of vaccine in study 1, and was not given in study 4. no adverse reactions were encountered in 179 vaccinated men, and 94% o ...	1976	1262709
[changes in the activity of succinate dehydrogenase in the cells of different brain structures under the effect of uhf field of low intensity].		1976	1274298
lymphocyte abnormalities in untreated patients with hodgkin's disease.	the study comprises 38 unselected and untreated patients with hodgkin's disease (hd) and 23 healthy persons. highly purified blood lymphocytes were analyzed for cells forming rosettes with sheep red blood cells (t lymphocytes), and lymphocytes bearing surface immunoglobulin (b lymphocytes) and/or carrying receptors for complement. their dna synthesis, spontaneously, or after activation with mitogens (phytohemagglutinin, concanavallin a, poke weed mitogen) and purified protein derivative (ppd) wa ...	1976	1082795
alteration of colony-stimulating factor output, endotoxemia, and granulopoiesis in cyclic neutropenia.	cellular and humoral factors involved in the regulation of granulopoiesis were evaluated in two patients with cyclic neutropenia by utilizing the agar-gel marrow culture technique to serially study marrow granulocytic colony-forming capacity (cfc) and the urinary output of colony-stimulating factor (csf). csf output varied inversely with peripheral neutrophil counts and directly with monocyte counts and evidence for infection (endotoxemia and/or staphylococcal abscesses). following autologous in ...	1976	1087533
[study of the incorporation of radioactive zinc in saccharomyces cerevisiae aldolase].	saccharomyces cerevisiae aldolase concentrates from the culture medium containing znso4 a large amount of zn which becomes a component part of the enzyme molecular structure. this was made evident by adding to the culture medium 65znso4 and measuring the radioactivity of the aldolase extracted by a phillips single channel analyzer.	1976	133445
studies of the histochemistry, ultrastructure, motor innervation, and regeneration of mammalian intrafusal muscle fibres.		1976	137430
sequential hepatic histologic and histochemical changes produced by diethylnitrosamine in the rhesus monkey.	six young adult male rhesus monkeys were given diethylnitrosamine ip for 3-5 years. liver biospies were done monthly. after 6 months, biopsy specimens showed individual hepatocytes and small foci of hepatocytes that were intensely positive for glycogen. during the second and later years, larger foci of such cells developed. in sections stained with hematoxylin and eosin, the glycogen-containing hepatocytes generally appeared unusually clear. some hepatocytes, however, had eosinophilic or basophi ...	1976	187798
the storage lipids in tangier disease. a physical chemical study.	the physical states and phase behavior of the lipids of the spleen, liver, and splenic artery from a 38-yr-old man with tangier disease were studied. many intracellular lipid droplets in the smectic liquid crystalline state were identified by polarizing microscopy in macrophages in both the spleen and liver, but not in the splenic artery. the droplets within individual cells melted sharply over a narrow temperature range, indicating a uniform lipid composition of the droplets of each cell. howev ...	1977	193870
purity and antigenicity of insulin preparations.		1977	98958
protective efficacy of pneumococcal polysaccharide vaccines.	clinical studies of 6- and 12-valent pneumococcal capsular polysaccharide vaccines were carried out in controlled studies among novice gold miners in south africa. in the studies 1,523 persons received pneumococcal vaccine, and 3,171 were included as controls. in the great majority of subjects given pneumococcal vaccine, antibodies developed against the capsular types included in the vaccine. the 6-valent vaccine afforded 76% reduction in cases of laboratory-verified pneumococcal pneumonia cause ...	1977	21973
serum gonadotropins in the rat after prenatal damage to the testes by busulfan and their reaction to cryptorchidism, castration and administration of testosterone.	adult male rats prenatally treated with 1,4-bis-(methanesulfonyloxy)-butane (busulfan), which damages the gonocytes, undergo cryptorchidization, castration or testosterone treatment and the fsh, lh and testosterone levels in serum are measured. basal values of these hormones do not differ from those of controls. after cryptorchidization fsh levels rise but the lh levels do not. following orchidectomy both hormone levels increase significantly. application of testosterone in various doses increas ...	1977	16621
effects of hydration and physical therapy on tracheal transport velocity.	a new tracer method for quantitative measurement of tracheal transport velocity (mm per min) in dogs has been described. using the same technique, the effects of dehydration, rehydration, postural drainage, and chest percussion on tracheal transport velocity were studied. mean tracheal transport velocity decreased significantly (14.1 +/- 1.4) after dehydration (p less than 0.05) and reverted to normal (19.0 +/- 1.3) with rehydration in 10 dogs. after postural drainage in 7 dogs, mean tracheal tr ...	1977	262095
[association between hsv 2 antigen and colpocytologic finding (author's transl)].	prophylactic gynecologic examinations were performed in 1440 women using colposcopy and vaginalcytology. a search for hsv antigen in cervical cells was performed hsv antigen was found in 12% of pap i--ii smears, in 41% of pap iii smears and in all cases of pap iv--v. it is suggested that there is a probable association between hsv 2 and cervical cancer.	1977	201227
epoxidation of aldrin to exo-dieldrin by soil bacteria.	twenty-two strains of soil bacteria, including representatives of the genera bacillus, micromonospora, mycobacterium, nocardia, streptomyces, thermoactinomyces, and pseudomonas and 10 unidentified gram-negative, motile, rod-shaped bacteria, were shown to degrade aldrin to its epoxide dieldrin. in every case, the exo-stereoisomer of dieldrin was produced exclusively.	1977	407844
man, medicine, and machines.		1977	406501
inhibition by somatostatin of adenosine-3',5'-monophosphate stimulated hepatic ribosomal protein synthesis.	somatostatin which inhibits the secretion of various pituitary and intestinal hormones has been suspected to exert these effects by inhibiting adenosine-3',5'-monophosphate accumulation in the respective endocrine gland. our results, obtained by cell free protein synthesis and by sedimentation through sucrose gradients of ribosomes, prepared from rat liver after incubation with cyclic amp and/or somatostatin also suggest this antagonism between somatostatin and cyclic amp. in addition, they indi ...	1977	197300
bovine superoxide dismutase: a radioimmunoassay.		1978	102252
gene assignments to the presumptive homologs of human chromosomes 2, 9, 13, 14, and 15 in the pongidae and cercopithecoidea.		1978	110529
[use of intraspecific differentiation of sh. sonnei for the purpose of studying patterns in the epidemic process of dysentery].	the use of complex typing of sh. sonnei by the colicinogenic and enzymatic properties in epidemiological analysis of dysentery caused by sh. sonnei, apart from establishment of epidemiological connections in the foci, offered a possibility of introducing significant corrections in the determination of the sizes and duration of existence of the epidemic foci, as well as in detection of the sources and factors of transmission of the infection established in epidemiological examination. typing of s ...	1978	154276
comparison of interferon action in interferon resistant and sensitive l1210 cells.	translation inhibition, leu-trna aminoacylation and double-stranded rna and atp dependent phosphorylation were examined in interferon-treated and control cell-free lysates of leukaemic mouse l 1210 r and l 1210 s cells. no differences were observed between the respective interferon-treated and control cell-free extracts, except for the presence of an enhanced 67k dalton phosphoprotein fraction in interferon-treated l 1210 s cell-free extracts. in non-responding cell-free lysates, the lack of sti ...	1978	212514
eosinophil chemotactic factor (ecf). iii. generation in human peripheral leukocytes.	eosinophil chemotactic factor (ecf) can be released from human peripheral leukocytes by an ige-anti-ige reaction, by the calcium ionophore a 23187 and during phagocytosis. supernatants and sonicates of unstimulated cells contain little or no ecf. on stimulation, however, ecf activity increases in the cells and even more so in the supernatants. this holds for purified neutrophils (pmns) as well as for basophil-containing mononuclear cell preparations. these findings contrast with those in lung ho ...	1978	344230
[autoradiographic studies on the distribution of 14c-piracetam in the simian brain].	autoradiography of the brain of the monkey callithrix jacchus 2 and 6 h after oral application of 200 mg 14c-piracetam/kg (2-oxo-pyrrolidine-l-acetamide-2-14c) shows that the drug is preferably concentrated in the cortex of cerebrum and cerebellum. this specific affinity of piracetam which was observed earlier in dog and rat is thus confirmed in the primate and seems to be species independent. beside the dominant cortical concentration there is a characteristic storage of piracetam in many nucle ...	1978	415743
[contributions of thoracic surgery in the research institute for pulmonary diseases and tuberculosis since its founding and under the presence conditions in the treatment of specific and nonspecific lung diseases (author's transl)].	thoracic surgery is done in the research institute for pulmonary diseases and tuberculosis for about 25 years. 2463 lung resections on account of tuberculosis, 934 lung resections on account of intrathoracic tumors, among them 795 suffering from bronchial carcinoma, 422 operations because of nonspecific pulmonary diseases (bronchiectasis, lung abscess a.s.o.) and nearly the same number of operations because of spontaneous pneumothorax were performed in this time. cystic lung disease, bullous emp ...	1979	516807
study of ve virus and isolation of sle, ee, group c, and guama group arboviruses in the amazon region of peru, 1975.		1979	519080
dna methylation: organ specific variations in the methylation pattern within and around ovalbumin and other chicken genes.	the restriction enzymes hhai and hpaii, whose activity is inhibited by cytosine methylation within their recognition sites, have been utilised as probes to study methylation in the vicinity of the ovalbumin gene in dna from various chicken tissues. this was complemented by a preliminary study of methylation in the regions of chicken ovotransferrin (conalbumin), ovomucoid and beta-globin genes. from our data we conclude that hai or hpaii sites can be divided in 3 classes according to their patter ...	1979	523314
plasma hemoglobin in rectal or intravenous hydrogen peroxide for extrapulmonary oxygenation.		1979	524918
vibrios in acute diarrhoea.		1979	544501
suppressor of deoxythmidine monophosphate uptake in saccharomyces cerevisiae.	although yeast cannot normally incorporate exogenous deoxythymidine 5'-monophosphate (dtmp) into deoxyribonucleic acid, mutants able to do so have been isolated. we have characterized a recessive suppressor of dtmp uptake (sot1) that prevents strains carrying either tup1, tup2, or tup4 from growing on selective medium. the sot1 mutation maps between rad1 and the centromere of chromosome xvi, and is unlinked to any of the tup mutations. the sot1 mutation does not suppress the other pleiotropic ef ...	1979	374400
localization of neurons supplying the temporalis muscle in the rat and monkey.	following injection of horseradish peroxidase (hrp) solution into the rat and monkey temporalis muscle, a similar pattern of nuclear representation was found in the motor trigeminal nucleus. labelled neurons were seen throughout the rostro-caudal extent of the ipsilateral motor trigeminal nucleus, in its dorsal, intermediate and ventral portions and its dorsomedial, ventromedial and ventrolateral corners. in addition to the motor trigeminal nucleus labelled neurons were also found in the ipsilat ...	1979	107492
non-h-2 antigens on fibroblasts and an embryocarcinoma cell line react with xenoantisera against h-2 antigens.	the murine embryocarcinoma cell line f9 lacks the classical transplantation antigens. however, rabbit anti-h-2 antigen sera, recognizing "backbone structures" of h-2 k and d antigens, react with three types of molecules manufactured by f9 cells. a 49,000- and a 25,000-dalton chain are glycoproteins located on the cell surface. the third component with an apparent molecular weight of 15,000, and the 25,000-dalton chain seem to be unrelated to the 49,000-dalton glycoprotein. the 25,000- and 15,000 ...	1979	91173
[differences in sensitivity of t3, t7, t4 and lambda phages to bleomycin and phleomycin].	in contrast to phage lambda the phages t3, t7 and t4 are not inhibited by as much as 150 microgram bleomycin/ml, while the chemically related antibiotic phleomycin increasingly inhibits the propagation of the phages in the order t4-t3-lambda. 20 microgram phleomycin/ml inhibit t3 by 95%. the resistance against bleomycin is surprising, because 10 microgram bm/ml block completely the colony-forming capacity of the host bacterium. the drug resistance of the phage growth correlates with the weak dec ...	1979	94958
[enzymes catalyzing the reduction of aldopentoses and the oxidation of pentitols in mycobacteria].	m. phlei, grown on synthetic sauton medium (with 6% glycerol as carbon source), had nadph- and nadh-aldopentose reductase, as well as nad-pentitol dehydrogenase activities; some of their properties are studied. these activities are not present in bcg grown on the same medium. all experiments of aldopentose-reductase induction in bcg on a d(+)xylose medium were negative.	1979	120778
[effect of sympathetic nerve stimulation on the microvascular permeability for proteins and lipoproteins].		1979	92794
dissolution of rabbit zona by sperm acrosomal extract: effect of calcium (1).	the acrosomal extracts from rabbit spermatozoa were more effective in dissolving the zona pellucida of the rabbit ova in the absence than in the presence of ca2+. the extracts had high proteolytic activity but low esterolytic activity at alkaline ph in which ph effective zona hydrolysis occurred. the results suggest that acrosomal proteinases in addition to acrosin may be involved in the zona penetration.	1979	38295
catabolite inactivation of phosphoenolpyruvate carboxykinase in spheroplasts from saccharomyces cerevisiae.	catabolite inactivation of phosphoenolpyruvate carboxykinase was studied in yeast spheroplasts using 0.9 m mannitol or 0.6 m potassium chloride as the osmotic support. in the presence of potassium chloride the rate of catabolite inactivation was nearly the same as that occurring in intact yeast cells under different conditions of incubation. however, in the presence of mannitol, catabolite inactivation in spheroplasts was prevented. the mannitol inhibition of catabolite inactivation was released ...	1979	383159
pharmacological modification of experimental tardive dyskinesia.	cebus apella monkeys subjected to chronic haloperidol administration develop neurologic disturbances very similar to neuroleptic-induced acute dystonia human beings. after varying lengths of time, certain monkeys develop a prolonged dyskinetic syndrome resembling tardive dyskinesia (td), as seen clinically. two monkeys with signs of td were given single intramuscular injections of various compounds with known effects on the catecholaminergic, cholinergic, serotoninergic and gaba-ergic neurotrans ...	1979	115227
the primary transcript of the ribosomal repeating unit in yeast.	endgroup analysis of 37s ribosomal precursor rna from saccharomyces carlsbergensis has revealed that the major 5' endgroup is ppa-up, with a molar yield of 0.8. this shows that most, if not all, 37s rna molecules have preserved a transcriptional initiation sequence. analysis of the 3' terminus of 37s rna has shown the presence of a uridine rich oligonucleotide, tentatively identified as u6-8-a-noh. this long stretch of uridines at the 3' end of 37s rna may represent a transcriptional termination ...	1979	106368
behavioral effects of low and high acute doses of morphine in solitary mice.	the effects of morphine (5, 10, 100, and 150 mg/kg sc) on locomotor activity, object manipulation, grooming, rearing, and responsiveness to social stimulation were observed in naive, nontolerant mice. morphine induced significant changes in the behavior elements recorded. five and 10 mg/kg morphine caused an initial phase of about 1 h with inhibition of all activities. after 1 h the mice gradually increased activity and exceeded the corresponding placebo level at the end of the sessions. 100 and ...	1979	113835
origin and early development of canine circumanal glands.		1979	517821
adults' simulations of preschoolers' human figure drawings.		1979	503734
middle tumor antigen of polyomavirus transformation-defective mutant ng59 is associated with pp60c-src.	we have found that lysis of mouse embryo cells infected with the polyomavirus host range transformation-defective (hr-t) mutant ng59 under gentle conditions that avoid ionic detergents results in detectable ng59-encoded middle tumor antigen (mtag) associated with pp60c-src. this mtag-pp60c-src complex could be immunoprecipitated from ng59-infected cell lysates by either sera from animals bearing polyomavirus-induced tumors or by monoclonal antibodies directed against mtag. immune complex kinase ...	1985	2981329
restriction endonuclease mapping and cloning of mycobacterium fortuitum var. fortuitum plasmid pal5000.	a restriction map of mycobacterium fortuitum var. fortuitum plasmid pal5000 was established. the unique sites for apai, bamhi, bglii, bsteii, clai, ecori, ecorv, hpai, kpni and nari were located on the 5.0-kb plasmid. the plasmid had no sites for ahaiii, bcli, hindiii, psti, sphi and xbai. pal5000 was cloned into pbr322 and propagated in escherichia coli. three hybrid pal5000-pbr322 plasmids carrying the complete pal5000 sequence were constructed by joining the plasmids at their bamhi, ecori or ...	1985	3002238
reduction of the slow inward current of isolated rat ventricular cells by thiamylal and halothane.	the barbiturates and halothane exert a negative inotropic effect on the myocardium. a reduction in the slow inward current, carried mainly by calcium ions, is an important factor for the underlying mechanism because the calcium current during the action potential provides the calcium ions for accompanying contraction, supplies ca ions to the sarcoplasmic reticulum for subsequent contractions, and induces ca release from the store site. it has been suggested that reduction in the slow inward curr ...	1985	2932881
glucokinase is not the pancreatic b-cell glucoreceptor.	a series of recent experimental findings are reviewed to indicate that glucokinase does not represent the pancreatic b-cell glucoreceptor. whether in liver, pancreatic islet or insulin-producing tumoral cell homogenates, glucokinase fails to yield a higher reaction velocity with alpha-than beta-d-glucose. at a high glucose concentration (40 mmol/l), when the phosphorylation of glucose by glucokinase is indeed higher with beta- than alpha-d-glucose, no preference for beta-d-glucose is observed in ...	1985	2996960
restriction endonuclease mapping and cloning of mycobacterium fortuitum var. fortuitum plasmid pal5000.	a restriction map of mycobacterium fortuitum var. fortuitum plasmid pal5000 was established. the unique sites for apai, bamhi, bglii, bsteii, clai, ecori, ecorv, hpai, kpni and nari were located on the 5.0-kb plasmid. the plasmid had no sites for ahaiii, bcli, hindiii, psti, sphi and xbai. pal5000 was cloned into pbr322 and propagated in escherichia coli. three hybrid pal5000-pbr322 plasmids carrying the complete pal5000 sequence were constructed by joining the plasmids at their bamhi, ecori or ...	1985	3002238
the interaction of tumour-localizing porphyrins with collagen, elastin, gelatin, fibrin and fibrinogen.	we have already reported in balb c mouse transplantable mammary carcinoma, that uroporphyrin i and iii are superior as tumour localizers when compared to hematoporphyrin derivative and a derivative thereof, photofrin ii. this study compares the binding of porphyrins to proteins which may be found in tumour cells or stroma to investigate whether there is a common binding determinant. coproporphyrin iii and deuteroporphyrin ix which are non-tumour localizing porphyrins, were also part of the compa ...	1985	3836016
osteocalcin in human serum: a circadian rhythm.	osteocalcin, the vitamin k-dependent protein synthesized in bone, is found in blood. the level of circulating osteocalcin has recently been used as an indicator of the rate of bone turnover. we measured serum osteocalcin during 24-h periods in 6 normal 20- to 30-yr-old men and 4 women. blood was sampled via an indwelling venous catheter every 30 or 60 min for 24 h. circadian rhythmicity in circulating osteocalcin was found in 9 of the 10 individuals studied. osteocalcin levels fell during the mo ...	1985	3871789
role of carbohydrates within variant surface glycoprotein of trypanosoma congolense. protection against proteolytic attack.	the effects of tunicamycin on different aspects of structure and biosynthesis of variant surface glycoprotein from trypanosoma congolense have been studied. deglycosylated variant antigen becomes synthesized in vitro, is transported through the cell, and is deposited on the cell surface in equivalent amounts compared to the glycosylated species. in contrast to the glycosylated molecule only marginal amounts of high-molecular-mass fragments can be removed from the parasitic cell by externally add ...	1985	3896788
presence of soluble, mycobacterium leprae-derived antigen in the inflammatory exudate of reactional lepromatous leprosy.		1985	3903409