| 3-o-alkylascorbic acids as free radical quenchers. 3. protective effect on coronary occlusion-reperfusion induced arrhythmias in anesthetized rats. | structural modification of ascorbic acid by substitution of the 3-hydroxy group with lipophilic moieties has allowed the development of agents for treating reperfusion injury. these ascorbic acid derivatives inhibited lipid peroxidation, and some of them also reduced coronary reperfusion-induced arrhythmias in anesthetized rats. we found that 3-o-[(dodecylcarbonyl)methyl]ascorbic acid (8) was protective against reperfusion injury without directly influencing hemodynamics. 2-o-octadecylascorbic a ... | 1992 | 1578489 |
| design of site-specific protein drugs. | the ability to clone and express proteins at high levels of abundance and purity has led to their increasing consideration as therapeutic agents. the use of various protein engineering and recombinant dna techniques has enabled progression to where proteins can be tailored so that they have not only the ability to interact with a unique (extra)cellular component in order to produce a pharmacological effect, but their structure can be altered so as to achieve a selective biological disposition. t ... | 1991 | 1815386 |
| functional and electrophysiological effects of oxidant stress on isolated ventricular muscle: a role for oscillatory calcium release from sarcoplasmic reticulum in arrhythmogenesis? | the aim was to investigate the cellular basis of oxidant stress induced arrhythmias by studying the influence of oxidant stress on the contractile and electrophysiological function of isolated cardiac muscle. | 1991 | 1913755 |
| autosomal dominant retinitis pigmentosa: exclusion of a gene from extensive regions of chromosomes 6, 13, 20, and 21. | members of a large pedigree of irish origin presenting with early onset type i autosomal dominant retinitis pigmentosa (adrp) have been typed for polymorphic dna markers from chromosomes 6, 13, 20, and 21. for each marker close linkage to adrp has been excluded by pairwise analyses. using distances fixed from well-established genetic maps of these chromosomes and multipoint analyses with two or three contiguous markers, exclusion of adrp was extended to the areas between markers, resulting in th ... | 1989 | 2613243 |
| biopharmaceutical evaluation of sustained-release ethylcellulose microcapsules containing amoxicillin using beagle dogs. | a beta-lactam antibiotic, amoxicillin, was microencapsulated with ethylcellulose using a solvent evaporation process in liquid paraffin containing sorbitan tristearate as a dispersing agent, and the microcapsules obtained showed first-order drug release. usage of the previous log-log relationship of cefadroxil between in vitro dissolution half-lives (t50) and the experimental release rate constants (k'r) of the drug in vivo, and the nomogram for the design of satisfactory sustained-release prepa ... | 1989 | 2632091 |
| human milk-derived lactoferrin inhibits mitogen and alloantigen induced human lymphocyte proliferation. | purified lactoferrin (lf), isolated from human milk, was tested for its effect on human t-lymphocyte proliferative responses to phytohemagglutinin (pha) and to alloantigens in mixed lymphocyte culture. lf inhibited proliferation in both assays in a dose-dependent manner. the suppressive effect was not due to lf mediated cytotoxicity since washing cells that had been pre-incubated with lf restored their proliferative activity. lf was most effective in suppressing the pha response when added withi ... | 1987 | 2963123 |
| evolution of pseudorabies virions containing genomes with an invertible long component after repeated passage in chicken embryo fibroblasts. | the genome of pseudorabies virus consists of two components, short (s) and long (l). only the s component is bracketed by inverted repeats, and only the s component inverts itself relative to the l component, giving rise to two isomeric forms of the genome. an attenuated vaccine strain of pseudorabies virus (norden), however, has a genome which is found in four isomeric forms (b. lomniczi, m. l. blankenship, and t. ben-porat, j. virol. 49:970-979, 1984). to determine the basis for the atypical s ... | 1987 | 3033309 |
| the carrier state: group b streptococcus. | | 1986 | 3528112 |
| case records of the massachusetts general hospital. weekly clinicopathological exercises. case 29-1986. an asplenic woman with evidence of sepsis and diffuse intravascular coagulation after a dog bite. | | 1986 | 3724816 |
| [new aspects and controversies on the vascularization of the white pulp of the spleen in the rat]. | the authors have studied the arterial supply of splenic white pulp of the rat, by means of optic and scanning electron microscopy. this work shows that the marginal zone is a free and interstitial circulatory one that envelopes completely the periarterial lymphocyte sheets. these ones are vascular exclusion areas although crossed by vessels, probably impermeable, that pour their contents at the inner border of the marginal zone. it was impossible to find a so called "marginal sinus" neither a co ... | 1985 | 3842273 |
| [leptotrichia buccalis--culture, biochemistry and antibiotics]. | | 1974 | 4154653 |
| [xantine oxidoreductase activity in the aorta wall of the rat (author's transl)]. | | 1974 | 4214422 |
| studies on the antibacterial and antifungal properties of 1, 4-naphthoquinones. | 1. new halogenated 1,4-naphthoquinones were synthesized and together with other known 1,4-naphthoquinones, were screened for antibacterial activity by a turbidimetric method, and for antifungal activity by the diffusion method on agar plates.2. the half-wave potentials and the influence on the oxidative phosphorylation of some of these compounds were determined.3. 2-chloro-3,2'-chloro-ethyl-1,4-naphthoquinone (half-wave potential=-187 mv) was the most active compound, completely inhibiting cell ... | 1970 | 4992959 |
| the oxidation of acetoin to co 2 in intact animals and in liver mince preparation. | | 1972 | 5029485 |
| [primary transport of acute patients. optimal use of rescue resources exemplified by the canton of graubünden]. | | 2011 | 3927607 |
| [essential arterial hypertension in patients with non-insulin-dependent diabetes mellitus during and after balneotherapy followed-up for 6 years]. | the statistical correlations between body weight, glycemia, total lipids, cholesterol in 200 patients with essential hypertension, especially borderline essential hypertension, followed up for 6 years indicate that the complex environmental factors in slănic-moldova health resort associated with balneotherapy may induce a return to normal values of the above mentioned parameters. good results were also obtained in the patients with essential hypertension and non-insulin dependent diabetes mellit ... | 2009 | 2636767 |
| insurers, hmos and bc/bs plans talk about aids. | | 2010 | 2910793 |
| [current approaches to immunological diagnosis of autoimmune and immune complex diseases]. | | 2010 | 2974642 |
| varied appearance of cardiac pseudoaneurysms on blood pool images. | three cases of cardiac pseudoaneurysms were presented, with findings at the time of gated blood pool imaging. in only one of three was there the finding of a small neck connecting the ventricular cavity with the pseudoaneurysm. in the other two patients, there was a considerably larger communication. the size of the pseudoaneurysm itself was also of little diagnostic assistance. in one case it was small, while in a second patient it was larger in size. the third case revealed a pseudoaneurysm of ... | 2013 | 3595025 |
| [what should be done in a meniscal lesion?]. | the treatment of meniscal lesions closely depends on the context in which they occur. in isolated lesions of the medial meniscus, meniscectomy under arthroscopy remains the best method. when the meniscal lesion complicates a rupture of the anterior cruciate ligament, meniscal suture associated with reconstruction of the ligament may be contemplated. in case of degeneration of the medial meniscus or lesion of the lateral meniscus, various therapeutic approaches may be envisaged. | 2008 | 2602876 |
| [possibilities of intracavitary contact therapy of the cervicofacial region using the decatron afterloading equipment]. | | 2013 | 3774996 |
| the under-reporting of alcohol use: the role of organic mental syndromes. | the under-reporting of alcohol use has been viewed as the consequence of alcoholic denial. alcoholic denial has been conceptualized as an unconscious ego defense. in this paper the authors present data suggesting that the under-reporting of alcohol use may be, in certain cases, the result of the influence of the organic mental syndromes commonly associated with alcoholism. | 2013 | 4053972 |
| [botanical and phytochemical investigations of species of the genus helleborus growing in europe and asian minor. iii. the quantitative contents of hellebrin in plants of the natural biotops and in culture (author's transl)]. | | 2015 | 4465819 |
| pathologic review of consecutive radical prostatectomy specimens. nerve sparing versus nonnerve sparing. | retrospective pathologic analysis was conducted of specimens from 88 radical retropubic prostatectomy operations performed between 1982 and 1987 inclusive. the median age of patients was sixty years (range, 46 to 73 years). of the 88 radical prostatectomies performed, 51 were nerve-sparing (40 bilateral) and 37 were nonnerve-sparing (11 unilateral) procedures. preoperative clinical staging was similar in both groups. thirty-five of 37 patients (95%) in nonnerve-staging group and 51 of 51 patient ... | 2007 | 1887533 |
| superficial and juxtamedullary nephron function during saline loading in the dog. | a modification of the microdissection technique of hanssen was utilized in dogs to measure superficial (sngfr) and juxtamedullary nephron filtration rate (jmgfr) in control and saline-expanded dogs. during control studies sngfr was 60+/-4 and jmgfr was 72+/-5 nl/min. during saline loading sngfr was 74+/-8 and jmgfr was 65+/-6 nl/min. the ratio sngfr: jmgfr significantly increased from 0.84+/-0.03 to 1.15+/-0.08. glomerular perfusion rate (gpr) was measured with the microsphere method during cont ... | 1974 | 4815088 |
| hydrogel keratophakia: a freehand pocket dissection in the monkey model. | high water content hydrogels can be made with water and solute permeabilities comparable to those of the corneal stroma, thus making them feasible as intrastromal implants for refractive keratoplasty. the materials have been shown to be compatible with the cornea tissue, but for a lenticule of hydrogel to be effective in a refractive keratoplasty procedure it must alter the anterior curvature of the cornea. in this investigation hydrogel lenticules were implanted by a free-hand pocket dissection ... | 1986 | 3954975 |
| relaxin on induction of parturition in beef heifers. | purified porcine relaxin (3000 u/mg) was administered into the cervical os of primiparous beef heifers on day 278 of gestation (approximately 5 days before parturition normally occurs) to determine its effects on the induction of parturition, changes in progesterone, estrone (e1), 17 beta-estradiol (17 beta-e2), cervical dilation, and pelvic relaxation. heifers were assigned randomly to 1 of 3 treatments: relaxin-double (two infusions of 3000 u, 12 h apart; n = 17), relaxin-single (3000 u; n = 1 ... | 1986 | 3753933 |
| teratogenicity studies of alkylaryl phosphate ester plasticizers in rats. | santicizer 141 plasticizer (2-ethylhexyldiphenyl phosphate) and santicizer 148 plasticizer (isodecyldiphenyl phosphate) were tested for teratogenic activity in charles river cobs cd rats. groups of 25 mated females were given 0, 300, 1000, or 3000 mg/kg/day by gavage on days 6 through 15 (santicizer 141) or 6 through 19 (santicizer 148) of gestation. mean maternal body weight gains were slightly and severely reduced at the mid- and high-dose levels of santicizer 141, respectively. body weights w ... | 1986 | 3732665 |
| arachidonic acid metabolism and renal allograft rejection. | | 1987 | 3274801 |
| serum albumin adducts in the molecular epidemiology of aflatoxin carcinogenesis: correlation with aflatoxin b1 intake and urinary excretion of aflatoxin m1. | aflatoxin-serum albumin adducts in the blood of 42 residents of guangxi province, people's republic of china, were determined and compared with intake of aflatoxin b1 (afb1) and excretion of aflatoxin m1 (afm1) in urine. blood specimens were obtained during the same period that urine was collected and that diet was sampled. serum albumin was isolated from blood by affinity chromatography on reactive blue 2-sepharose and subjected to enzymatic proteolysis using pronase. immunoreactive products we ... | 1988 | 3133131 |
| diabetic embryopathy and fuel-mediated organ teratogenesis: lessons from animal models. | the growing recognition that faulty maternal metabolism during early organogenesis may be implicated in the increased incidence of birth defects in pregnancies complicated by diabetes has prompted worldwide efforts to institute improved preconceptional metabolic regulation. however, the failure to identify the periods of greatest risk for diabetic embryopathy, the mediating teratogen(s), and the underlying mechanisms have complicated attempts to establish precise therapeutic guidelines and targe ... | 1988 | 3053387 |
| localization of basic fibroblast growth factor to the developing capillaries of the bovine retina. | the basic fibroblast growth factor (fgf) is a potent mitogen that has vascular endothelium as one of its principle target cells. recent work has provided both the complete amino acid sequence of basic fgf and the nucleotide sequence of the genes for both human and bovine basic fgf. although capillary endothelial cells have been shown to produce basic fgf in vitro and to deposit basic fgf in their extracellular matrix in vitro as well, no direct evidence yet exists for the distribution of basic f ... | 1989 | 2910880 |
| an attempt at selective protection from phenoxybenzamine of postjunctional alpha-adrenoceptor subtypes mediating contractions to noradrenaline in the rabbit isolated saphenous vein. | 1. an attempt has been made, with the irreversible alpha-adrenoceptor antagonist phenoxybenzamine, to find the conditions under which postjunctional alpha 1-adrenoceptors in the rabbit isolated saphenous vein can be inactivated, such that postjunctional alpha 2-adrenoceptors can be studied in isolation. 2. following exposure to various concentrations of phenoxybenzamine, no evidence was found for a selective inactivation of the postjunctional population of alpha 1-adrenoceptors: the "rauwolscine ... | 1988 | 2906558 |
| glucagon, glicentin, proglucagon, pyy, pp and propp-icosapeptide immunoreactivities of rectal carcinoid tumors and related non-tumor cells. | glucagon/pp-related peptides were detected immunohistochemically in 18 out of 22 cases of rectal tumors investigated. the reactive tumors showed prevalence of trabecular or mixed trabecular-acinar structure and moderate staining with grimelius' silver and lead-hematoxylin. three of the remaining 4 cases were characterized by reactivity for 5-hydroxytryptamine only, prevalence of a solid nest structural component and intense staining with grimelius' silver technique and lead-hematoxylin. fifteen ... | 1987 | 2882565 |
| assessment of abdominal fat deposition in female cynomolgus monkeys. | computed tomography (ct) was used to assess abdominal fat distribution in adult, female cynomolgus macaques (macaca fascicularis). the technique used was similar to that applied in human beings and allowed intra-abdominal, subcutaneous and total abdominal fat to be quantitated in 1 cm thick sections. correlations between single scans and the average of scans at several levels ranged from r = 0.96 to r = 1.00, indicating that a single scan is representative of abdominal fat distribution. signific ... | 1991 | 2045214 |
| fatal ureaplasmal pneumonia and sepsis in a newborn infant. | ureaplasma urealyticum was isolated in pure culture from blood tracheal aspirate and lung tissue in a newborn infant, who died of a severe pneumonia within 48 h after birth. the clinical course was characterized by persistent pulmonary hypertension of the newborn (pphn). post-mortem examination revealed extensive hyaline membrane formation combined with signs of inflammation in both lungs. the clinical and histopathological picture resembled that of early onset group b haemolytic streptococcal p ... | 1991 | 1959541 |
| anatomy of the digits. | digital surgery of the foot is performed on a regular basis. knowledge of the anatomy is of particular importance in order to appreciate the pathophysiology of the deformity. with this understanding, the surgeon can then address the problems at the appropriate level. | 2010 | 2937521 |
| [salt fluoridation in 4 colombian communities. vii. relationship between various nutrients and dental caries]. | | 2002 | 127591 |
| thyroid function in affective disorders and alcoholism. | the psychoneuroendocrinology of mood disorders and alcoholism is reviewed here. for reasons of both space and clarity, the article focuses on the clinical data and largely omits the basic science data. | 2011 | 3132602 |
| [is solcoderm suitable for treating malignant skin tumors?]. | solcoderm, a liquid preparation developed in the ussr, is recommended for topical treatment of benign and malignant skin tumors. we present 5 out of 25 patients treated in our department over the past 2 years who had been treated with solcoderm for malignant skin tumors. the preparation appeared to have affected only the superficial layers of the tumor and had not penetrated in depth. cellular remnants tended to spread far beyond the confines of the original tumor and seemed to become much more ... | 2008 | 2583604 |
| [operative management of esophageal perforations]. | | 2014 | 4017775 |
| [rare anomalies of the architecture of the bronchial tree]. | six cases of rare bronchial anomalies are presented (3 complete right-sided hypo-arterial bronchial distributions, 1 partial right-sided hypo-arterial bronchial supply of the upper lobe, 2 cases of atresia of the left apico-posterior bronchus). emphasis is placed on the bronchographic elucidation of the changed bronchial segmental topic if additive or subtractive bronchial anomalies are found endoscopically especially with regard to preoperative aspects. | 2011 | 3025954 |
| single unit response of suprachiasmatic neurons to arginine vasopressin (avp) is mediated by a v1-like receptor in the hamster. | a large population of local circuit neurons within the suprachiasmatic nucleus (scn) exhibit immunopositive staining for arginine-vasopressin (avp). avp has been reported to be released from scn neurons in a circadian pattern that peaks during the subjective day. using an in vitro hypothalamic slice preparation, the present study investigated how scn neurons respond to avp over the circadian cycle and whether the response to avp is mediated by v1- or v2-like avp receptors. exposure of the slice ... | 2009 | 2702494 |
| ownership and quality of care in residential facilities for the elderly. | the quality of care older people receive in a residential facility is related to its ownership. nonprofit facilities (n = 44) provided a more comfortable physical environment, more cohesive relationships, and more resident control than proprietary settings (n = 44) matched for size and resident functioning. veterans facilities (n = 44) offered more services and a more diverse staff, but their policies permitted less resident autonomy and their social climates were less cohesive than community fa ... | 2009 | 2753380 |
| placebo-controlled trial of quinine therapy for nocturnal leg cramps. | a prospective, double-blind, placebo-controlled crossover study of the use of quinine for nocturnal leg cramps was carried out in 8 elderly volunteer patients. the patients were randomly assigned to receive either placebo or 200 mg of quinine sulfate by mouth at bedtime. after 4 weeks of treatment and after a one-week washout period, the group taking quinine switched to placebo and vice versa for another 4 weeks. the differences in the number, duration, and severity of cramps and the side effect ... | 2009 | 2669346 |
| quantitative gamma-ray computed tomography of the radius in normal subjects and osteoporotic patients. | a new design of gamma-ray computed tomography (ct) scanner was used to measure bone density in 516 normal adults and in 116 female patients with osteoporotic fractures. trabecular bone density (tbd) was measured for a core of the ultradistal radius; cortical bone mass per unit length (mls) and mass per unit volume (mvs) were computed for the radius shaft. tbd, mls and mvs peaked at the age of about 40 in females and fell by 32%, 15% and 24%, respectively, by the age of 65. in males, tbd decrease ... | 2006 | 2242474 |
| acrylic resin finger prosthesis. | a technique is described for the prosthetic replacement of two fingers using acrylic resin. retention was obtained using finger rings. the stages of the technique are outlined. advantages and disadvantages are briefly stated. | 2006 | 1484252 |
| [treatment of colonic atresia and stenosis]. | | 2016 | 5047622 |
| editorial: the significance of food poisoning in canada. | | 2016 | 4841214 |
| on the diphasic nature of vasovagal fainting associated with blood-injury-illness phobia. | a detailed psychophysiologic analysis of a vasovagal faint occurring in a "blood-injury-illness" phobic demonstrated that the syncopal episode consisted of a diphasic response. this lends support to the hypothesis that vasovagal fainting in these patients is caused by an overcompensating rebound parasympathetic activation following sympathetic arousal. treatment and research implications of this finding are discussed. | 2011 | 4000732 |
| surgical treatment of chronic pancreatitis. | to contribute to the solution of the problems related to the treatment of chronic pancreatitis, a retrospective study was carried out on 60 cases of chronic pancreatitis treated by surgery over a period of 20 years. on the basis of the obtained results, it is believed that the derivative procedures are more likely to be successful in the treatment of the disease. pancreaticojejunostomy according to puestow should be the procedure of choice, since it shows a lower pre-and postoperative risk while ... | 2012 | 3557933 |
| thanatophoric dwarfism: a parent's point of view. | | 2013 | 3996686 |
| what role will residency education take in the profession by the year 2000? | residency education has enjoyed relatively slow but steady growth since its inception in the mid-1970s. a certain segment of recent graduates consider graduation from optometry school as entry level and perceive the need for additional clinical education. the creation of new residency programs and the expansion of existing ones may occur in a variety of settings. for residency education to realize its full potential, optometry must seek federal support for post-graduate clinical education. this ... | 2006 | 1447463 |
| [sonographic follow-up of secondary fracture healing. initial experiences with morphologic and semiquantitative assessment of periosteal callus formation]. | we report on the contribution of real-time sonography in comparison to plain radiographs to the assessment of fracture healing of 121 patients suffering fractures of the long bones of the lower limbs. sonographic morphology of periosteal callus metamorphosis shows basically a persistent increase of echogenicity representing the temporal range from fracture haematoma to the "woven bone". further criteria are the homogeneity of structure and the development of a marginal interface. nonunion radiol ... | 2007 | 2168063 |
| igm-containing immune complexes and antiphospholipid antibodies in patients with sneddon's syndrome. | we report three patients with a sneddon syndrome in whom predominantly small (500-900 kd) igm-containing serum immune complexes were detectable. furthermore, antiphospholipid antibodies and increased von willebrand factor antigen were found in the sera of two cases. especially the data demonstrating small circulating immune complex as suggest that sneddon's syndrome, a rare vasculitis disorder, might immunologically be characterized by circulating igm-containing immune complexes which, in additi ... | 2009 | 2772486 |
| employed mothers' concerns about separation from the first- and second-born child. | the effect of birth order on mothers' anxiety about separation from their infants was examined. forty employed mothers were assessed in 1982 when their firstborns were 7 months old and again when their second-borns were 7 months old. assessment included two measures: an interview-based rating scale (ibrs) and the maternal separation anxiety scale (msas). findings revealed that mothers felt less guilt and anxiety about separation from their second-borns than they had from their first-borns at a s ... | 2009 | 2704838 |
| recall strategies reported to be used by general dental practitioners in scotland. | | 2011 | 3165659 |
| biochemical rationale and myocardial tissue data on the effective therapy of cardiomyopathy with coenzyme q10. | the tissue levels of coenzyme q10 (coq10) in endomyocardial biopsy samples and blood from 43 patients with cardiomyopathy were determined by steps of extraction, purification, and hplc. the biopsy samples were obtained from the patients after a routine heart catheterization. six patients were of class i, 18 of class ii, 11 of class iii, and 8 of class iv (classified according to guidelines of the new york heart association). true control biopsies of healthy hearts are not available for ethical r ... | 2013 | 3856239 |
| pattern detection and the two-dimensional fourier transform: circular targets. | | 2005 | 1166624 |
| the effect of abdominal surgery on the serum concentration of the tumour-associated antigen ca 125. | the ca 125 assay is used to monitor the course of disease in women with adenocarcinoma of the genital tract. we measured serum ca 125 levels longitudinally in three different groups of patients who had normal serum ca 125 levels (less than or equal to 16 u/ml) before extensive intraperitoneal abdominal surgery (group 1, second-look laparotomy in 28 women with ovarian cancer; group 2, radical hysterectomy in 42 patients with cervical cancer; group 3, 13 men and one woman who had aortic surgery fo ... | 2007 | 2223686 |
| the effect of abdominal surgery on the serum concentration of the tumour-associated antigen ca 125. | the ca 125 assay is used to monitor the course of disease in women with adenocarcinoma of the genital tract. we measured serum ca 125 levels longitudinally in three different groups of patients who had normal serum ca 125 levels (less than or equal to 16 u/ml) before extensive intraperitoneal abdominal surgery (group 1, second-look laparotomy in 28 women with ovarian cancer; group 2, radical hysterectomy in 42 patients with cervical cancer; group 3, 13 men and one woman who had aortic surgery fo ... | 2007 | 2223686 |
| traumatic neuronal injury in vitro is attenuated by nmda antagonists. | pure traumatic neuronal injury was modeled in dispersed neocortical cell cultures derived from fetal mice. a plastic stylet was used to tear the neuronal and glial cell layer; medium oxygen content, ph, and glucose remained unchanged. adjacent to this local disruption, many neurons developed acute swelling and went on to degenerate over the next day, but glia were relatively spared. if the same mechanical insult was delivered in the presence of the n-methyl-d-aspartate (nmda) antagonists dextror ... | 2008 | 2576374 |
| mobilization of ferritin-iron by the anticancer agent bleomycin. | | 2008 | 2440448 |
| [the early treatment of children with cheilognathopalatoschisis--the orthodontic aspects]. | maxillary alveolar arch morphology and growth was studied in 15 children with complete unilateral cleft lip and palate treated with passive orthopaedic plates. nine patients were treated to the "zurich concept" and compared to six children who had lip surgery and primary bone-grafting at about six months of age and complete palate closure at 18 months. maxillary alveolar arch morphology was described at birth, at six months, at 18 months and at 4.5 years. after early orthopaedic treatment the al ... | 2008 | 2227738 |
| resistance of cytotoxic t lymphocytes to lysis by a clone of cytotoxic t lymphocytes. | to investigate how cytotoxic t lymphocytes (ctl) avoid killing themselves when they destroy target cells, we compared 20 different cell lines as target cells, including several ctl cell lines, for their susceptibility to lysis by ctl. variations in recognition of this diverse set of target cells was circumvented by attaching to all of them a monoclonal antibody to the antigen-specific receptor of a cloned ctl cell line (clone 2c) and using the 2c cell line as the standard aggressor or effector c ... | 2010 | 2953028 |
| early phase of juvenile iddm--environmental and genetic intervention. | | 2011 | 3144852 |
| [aids information]. | | 2011 | 3144632 |
| periostitis ossificans versus garrè's osteomyelitis. part ii: radiologic analysis of 93 cases in the jaws. | ninety-three clinically and radiologically diagnosed cases of periostitis ossificans were gathered over a 13-year period. histologic specimens were available in 19 cases. the predominant age, race, and gender were determined. the position of the periosteal reaction, its average length and width, and radiographs required to best demonstrate it were also established. sequestra were present in two thirds of the cases. radiographic features and associated clinical findings are described. | 2011 | 3140161 |
| record linkage study of hypokalaemia in hospitalized patients. | retrospective analysis of biochemical data from 58,167 hospital inpatients revealed that 21% developed hypokalaemia during hospitalization-in 5.2% the serum potassium was less than 3.0 mmol/l. subsequent evaluation showed a positive correlation between hypokalaemia and both female sex and hospital mortality. patients with leukaemia and lymphoid tumours, especially when receiving antibiotic or cytotoxic therapy, and patients with gastro-intestinal malignancy were amongst those most frequently exp ... | 2013 | 3714603 |
| [effect of prolonged physical work using submaximal and extreme force on mass-transfer and oxygen utilization]. | | 2014 | 4076687 |
| alterations of regional cerebral blood flow and oxygen metabolism in parkinson's disease. | regional cerebral blood flow (rcbf) and oxygen metabolism (rcmro2) were determined in six normals, six unilateral parkinson's disease (pd) patients, and eight bilateral pd patients. in the unilateral patients, rcbf and rcmro2 in the basal ganglia contralateral to the symptomatic limbs was 13% higher than on the other side (p less than 0.01); in the frontal cortex it was 8% lower than the other side, suggesting abnormal neuronal function in both regions. the bilateral pd patients had a widespread ... | 2014 | 4033924 |
| possible adverse reactions to an enzyme-containing washing powder. | following the launch of an enzyme (alcalase) containing washing powder, the manufacturers received numerous complaints from domestic users suggesting that it was responsible either for the precipitation of a rash or the exacerbation of a pre-existing rash. the 255 individuals living in london postal districts who complained to the manufacturers were contacted: 80 of them agreed to be investigated by patch and prick testing, and to a user test involving the double blind wearing of vests washed wi ... | 2014 | 3902354 |
| intermittent positive pressure ventilation by nasal mask: technique and applications. | intermittent positive pressure ventilation delivered non-invasively through a well-fitting nasal mask has been used to control nocturnal hypoventilation in three patients with severe, combined cardiorespiratory and skeletal disease. the advantages of this approach to domiciliary ventilation are described and the requirements of the ventilator are defined. | 2011 | 3283191 |
| the effect of metabolic disorders on brain activity. | | 2015 | 4717173 |
| the effect of metabolic disorders on brain activity. | | 2015 | 4717173 |
| [the role of the v. m. bekhterev school in the formation of pathopsychology]. | | 2015 | 4592883 |
| detection of mutations in insulin-receptor gene in niddm patients by analysis of single-stranded conformation polymorphisms. | we used the recently described technique of single-stranded conformation-polymorphism (sscp) analysis to examine the insulin-receptor locus. first, the ability of the method to detect known mutations and polymorphisms in the insulin-receptor coding sequence was assessed. regions of the insulin-receptor sequence containing 16 different nucleotide changes, 9 in patient genomic dna and 7 as cloned cdna in plasmids, were analyzed. all 9 patient genomic dna mutants and 5 of 7 plasmid mutants exhibite ... | 2007 | 2040394 |
| airborne mineral fibre concentrations in an urban area near an asbestos-cement plant. | ambient air concentrations of asbestos and total mineral fibres were measured during the period june-july 1985 at several locations near a large asbestos-cement factory located in the proximity of a northern italian town. measurements of the number and type of fibres were made by means of analytical scanning electron microscopy and energy-dispersive x-ray analysis (sem-edxa), essentially according to the rtm2 reference method of the asbestos international association. total mineral fibre concent ... | 2009 | 2744833 |
| acute butylglycol intoxication: a case report. | a rare case of butylglycol intoxication in a suicide attempt is reported. coma and hypotension were present on admission and severe metabolic acidosis arose subsequently. forced diuresis and haemodialysis led to an uneventful outcome. | 2009 | 2744782 |