Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [chronic peritoneal dialysis]. | 1982 | 1158281 | |
| d-ala2, deltazphe4-methionine enkephalin amide, a dehydropeptide hormone. | 1982 | 216357 | |
| what causes atherosclerosis? | 1982 | 216608 | |
| training odas. | 1982 | 426258 | |
| serum thymic factor in subacute sclerosing panencephalitis patients. | 1983 | 217563 | |
| studies on etiology of essential hypertension. hemodynamics, water-sodium balance and response to pressor substances during long-term sodium restriction and after spontaneous blood pressure fall--. | ci, tpri, pv, ecfv, nae, pra and a pressor response to na and at was measured before and after 1) sodium restriction and 2) spontaneous blood pressure fall (spontaneous fall) in the patients with essential hypertension and the following results were obtained. 1) ci did not change during sodium restriction and increased after spontaneous fall. tpri was reduced and the degree of this reduction was positively correlated with that of blood pressure reduction under these two conditions. 2) sodium res ... | 1983 | 1152191 |
| impact of a retention program for disadvantaged medical students upon the medical school community. | 1983 | 1152008 | |
| the cape town obstetric flying squad. | the number and nature of the calls received by the cape town flying squad service during 1972 are compared with those received from 1954 to 1960. a threefold increase in the total number of calls received per year is related to a fall from 74% to 30% in calls connected with postpartum complications. reasons for these changes are suggested. | 1983 | 1154169 |
| state monitoring and control of fluoridation. | 1983 | 1066003 | |
| [radiotherapy of carcinoma of the nasopharynz: clinical results (author's transl)]. | a series of 64 patients with malignant tumours of the nasopharynx treated by cobalt irradiation is analyzed. the crude 5-year survival rate for the entire epithelial group was 32%; 55% for n- group, 25% for n+. treatment methods avoiding complications are discussed. | 1983 | 217394 |
| deinstitutionalization and community placement: clinical and environmental factors. | 1983 | 221780 | |
| lung transplantation. | 1983 | 325760 | |
| aspartate-taurine imbalance in dominantly inherited olivopontocerebellar atrophy. | amino acids were measured in autopsied brain from two patients who died with a dominantly inherited form of olivopontocerebellar atrophy. neuropathologic changes found in the brain of these patients suggested a loss of cerebellar climbing fibers. the contents of aspartic acid, gamma-aminobutyric acid, and homocarnosine were reduced in the cerebellar cortex and the dentate nucleus, while taurine content was markedly elevated in the same brain regions. these findings are compatible with the possib ... | 1984 | 557761 |
| [unusual evolution of 2 tympano-jugular chemodectomas]. | 1984 | 215700 | |
| autogenous marrow-cancellous bone grafting in a patient with hand-schüller-christian disease. | 1984 | 344843 | |
| [significance of computed tomography in therapeutic diagnosis of brain tumors (author's transl)]. | because of its noninvasive property of direct imaging of the size and shape of the lesion, ct scan is significant not only for the diagnosis of the brain tumors, but also for the assessment of its chronological and/or therapeutic change in size. contrary to the conventional cerebral angiography and contrast encephalography, ct scan is feasible to detect the tumor repeatedly at short intervals. from march 1976 to october 1977, 197 cases of brain tumors were examined by ct, 6 tumors (1 pineal tumo ... | 1985 | 215926 |
| [a case of macrodontia (author's transl)]. | 1985 | 397436 | |
| [hepatocellular carcinoma simulating an acute abdomen]. | 1985 | 214828 | |
| the concentration of ketone bodies, free fatty acids, and glycerol in the blood of obese perons after injection of insulin and glucose. studies before and during absolute fasting. | the blood patterns of acetoacetate (aa), 3-hydroxybutyrate (3-hb), free fatty acids, and glycerol were registered after intravenous injection of insulin or glucose in seven obese persons. in each individual investigated the study with insulin was carried out first and that with glucose 2 days later. both sets of studies were repeated after 8 and 10 days of absolute fasting. in the studies both before and during fasting the concentration of aa and 3-hb in blood varied independently of lipolysis. ... | 1985 | 1145108 |
| inpatient psychiatric women's groups: the concept of sexuality. | 1985 | 219190 | |
| plant cell cultures, a potential source of pharmaceuticals. | 1985 | 397737 | |
| characterization of elevated plasma alkaline phosphatase activity in genetically obese mice. | alkaline phosphatase activity in obese mice (c57bl/6j ob/ob) was significantly increased from 18 to 63 weeks of age when compared to that of their lean controls (c57bl/6j +/?). in 5 week old animals, the earliest age examined, the circulating activity of alkaline phosphatase was similar in both obese mice and their lean counterparts. to characterize the circulating alkaline phosphatase activity in the obese mouse and its lean counterpart, the response of the enzyme to fasting, various inhibitors ... | 1985 | 2579311 |
| complex membrane transport systems. a non-markovian approach. | this paper suggests a method of how to deal with complex membrane transport systems such as ion channels or ion pumps formed by proteins. the complexity of these systems results from the fact that proteins may undergo an internal dynamics of conformational changes and may thereby affect the transmembrane transport. usually, complex transport systems are mapped into multi-state graphs and couched in terms of markovian master equations. it is shown in this paper how the dimensionality of such mult ... | 1985 | 2578832 |
| control of needle hole bleeding with ethyl-cyanoacrylate glue (krazy glue). | needle hole bleeding from polytetrafluoroethylene (ptfe) grafts causes blood loss and prolongs vascular procedures. past studies have shown the cyanoacrylate glues to polymerize rapidly and cause minimal tissue toxicity. this study was undertaken to evaluate the efficacy of ethyl-2-cyanoacrylate glue (krazy glue, kg) in obtaining prompt hemostasis in vascular anastomoses in a heparinized canine model. kg effected complete hemostasis in a significantly shorter time than oxidized cellulose and dig ... | 1985 | 3999241 |
| trifluoperazine protection of hypoxic myocardium. | effect of trifluoperazine (tfp) (2.5 x 10(-7) m and 2.5 x 10(-6)m)--an inhibitor of calmodulin, on langendorff-perfused rabbit hearts was examined. in the normoxic hearts tfp increased coronary flow and reduced force of contraction and oxygen consumption. in the hearts subjected to 180 min hypoxia followed by 30 min reoxygenation tfp reduced hypoxic release of ldh by approx. 50% and improved recovery of coronary flow, oxygen consumption and force of contraction upon reoxygenation suggesting prot ... | 1985 | 3832010 |
| regional turnover of norepinephrine and dopamine in rat brain following acute exposure to air ions. | exposure to air ions has been reported to influence serotonin (5ht), although critical reviews of these studies and previous measurements in our laboratory of the concentration, release, and utilization of brain 5ht indicate that neither the data nor the interpretations of the data are particularly convincing. measurements of other possibly relevant neurotransmitter systems--norepinephrine (ne) and dopamine (da)--were made in brain regions selected because of their importance in the modulation o ... | 1985 | 3836681 |
| confirmatory testing of rotazyme results in neonates. | 1985 | 3894609 | |
| a comparison of histopathologic changes following x-irradiation of mid-thoracic and lumbosacral levels of neonatal rat spinal cord. | light microscopic changes were studied in the dorsal funiculi of spinal cords from rats irradiated (4000 r) at 3 days of age and killed from 9-60 days postirradiation (p-i). the irradiated site was limited to a 5-mm length of mid-thoracic spinal cord (t only) in one group of rats, to a 5-mm length of lumbosacral spinal cord (l only) in a second group, and to 5-mm lengths of both mid-thoracic and lumbosacral spinal cord (t/l) in the third group. changes in the lumbosacral regions were essentially ... | 1985 | 3977087 |
| adhesive membrane protein of rat brain enhances neurite outgrowth of neuroblastoma cells. | a protein that stimulates neurite outgrowth of neuroblastoma cells has been solubilized with octyl glucoside from cell membranes of young rat brain. neuroblastoma cells from clones n 18 and nie 115 adhere and rapidly extend neurite-like processes when cells suspended in a serum-free medium are added to polystyrene wells coated with the protein. the activity of the solubilized substance is comparable to that of fibronectin and laminin. the following characteristics of the active substance are des ... | 1985 | 3979405 |
| metastatic nontraumatic clostridium septicum osteomyelitis. | nontraumatic clostridial infections are rare, but need to be diagnosed and treated early or high morbidity and mortality rates result. we believe that this is the first reported case of metastatic nontraumatic clostridium septicum osteomyelitis. early treatment with surgical debridement and parenteral antibiotics without hyperbaric oxygen was used. an associated occult rectal malignancy was discovered and treated. | 1985 | 3980945 |
| [functional characterization of microcirculation in tumors: chemotherapeutic implications]. | this report describes some aspects of tumor vessels and the functional characteristics of tumor microcirculation with regard to selective increase in tumor blood flow. elevation of the mean arterial blood pressure to about 150mmhg by angiotensin ii resulted in a several-fold increase in blood flow in tumor tissues without increasing blood flow in normal tissues. pressure elevation by angio-tensin ii also selectively increased tumor blood flow in intra-corneally transplanted microfoci and influx ... | 1985 | 3985643 |
| the incidence of helminth parasites from the wild rabbit oryctolagus cuniculus (l.) in eastern scotland. | samples of wild rabbits were collected each month over the six-year period 1977-82 and their intestines and abdomens examined for helminths. three species of nematode, four of cestode and one trematode were found. graphidium strigosum was recorded in 33% of the 786 rabbits, trichostrongylus retortaeformis in 79%, passalurus ambiguus in 14.2%, cittotaenia pectinata in 37%, c. denticulata in 11%, coenurus pisiformis in 3%, cysticercus serialis in 0.1% and fasciola hepatica in 0.1%. g. strigosum an ... | 1985 | 3989265 |
| effect of early maternal deprivation on brain 5-ht & pentobarbitone sleeping time in suckling rats. | 1985 | 4018858 | |
| effects of retinoids on invasion of organ cultures of chick chorioallantoic membrane by adenovirus transformed cells. | invasion of chick chorioallantoic membrane (cam) organ cultures by rat 3y1 cells transformed by the highly oncogenic human adenovirus type 12 (3y1/12-10 cells) was inhibited by several retinoids tested. the anti-invasive activity of the retinoids was dependent on retinoid concentration and continuous (4 d) exposure of the cam. the 50% retinoid dose (dose effective in achieving a response in half of the organ cultures) that inhibited invasion was 0.85 micrograms/ml of retinol palmitate, 0.39 micr ... | 1985 | 4030624 |
| automated methods for determination of fat and moisture in meat and poultry products: collaborative study. | a collaborative study was conducted to compare automated methods for rapid determination of fat and moisture in meat and poultry products with the official aoac solvent extraction and forced-air oven methods, respectively. fourteen products were tested, with fat and moisture contents ranging from 2 to 43% and 44 to 74%, respectively. eight of the collaborating laboratories analyzed the products by using a moisture/fat analyzer; 4 laboratories used the aoac methods. standard deviations for within ... | 1985 | 4055632 |
| [radioimmunodetection using 131i-labeled anti-carcinoembryonic antigen antibodies for human malignant tumors]. | 1985 | 4057687 | |
| volume overload hypertrophy elicited by cold and its effects on myocardial capillarity. | capillarity and fiber cross-sectional areas were measured in the hearts of guinea pigs exposed to cold early during growth. twelve male guinea pigs were kept at 5 +/- 1 degrees c for 4-18 weeks. hearts were perfusion fixed via the aorta with a 2.5% glutaraldehyde, 1% formaldehyde-buffered solution, blocks were cut from left (lv) and right (rv) ventricles, post-fixed in oso4, dehydrated and embedded in spurr medium. blocks were cut transversely to fiber orientation, 0.5 micron thick, stained with ... | 1985 | 3156396 |
| [influence of bovine parathyroid hormone-(1-34) on the contraction of the rat vas deferens and the effect of calcium]. | 1985 | 3158160 | |
| [mechanism of ischemic disorders of fatty acid oxidation in heart mitochondria]. | the article deals with the effect of permanent, temporal and total myocardial ischemia on the oxidation of acetate, hexanoate, palmitoylcarnitine and palmitoyl-coa in isolated rabbit heart mitochondria. all the three models of ischemia in different experimental situations demonstrated a similar degree of fatty acid oxidation suppression independent of the length of acyl residue, the suppression being the greatest during the first hours and in total ischemia. both in the control and in ischemia, ... | 1985 | 2988585 |
| stimulation of a cell-mediated cytotoxic response to felv-induced t cell lymphomas in the cat. | nonspecific cell-mediated cytotoxicity was examined in the peripheral blood and spleens of normal and vaccinia virus-infected adult domestic cats. natural cytotoxic (nc)-like cells, as measured by lysis of vaccinia- or hsv-infected, adherent cat tongue cells, were found in both the spleen and peripheral blood of normal, nonimmune cats. cytotoxicity was expressed in a 16-hr assay but not in a 4-hr assay. natural killer (nk)-like cells, as measured by lysis of an felv-induced lymphoid tumor cell l ... | 1985 | 2993416 |
| polyphosphoinositide metabolism in aging human erythrocytes. | normal human erythrocytes were fractionated in a density gradient. capacity to metabolize polyphosphoinositides was compared in young (least dense) and old (most dense) cells. polyphosphoinositide synthesis was assessed by following the incorporation of radioactivity from [gamma-32p]atp into the 1-(3-sn-phosphatidyl)-d-myo-inositol 4-phosphate (ptdins4p) and 1-(3-sn-phosphatidyl)-d-myo-inositol 4,5-bisphosphate (ptdins(4,5)p2) of isolated membranes. there was no significant age-dependent change ... | 1985 | 3000548 |
| labelling of liver glutamate by [1-14c]- and [2-14c]-pyruvate as a measure of oxaloacetate-fumarate disequilibrium in the mitochondria. | 1985 | 2860898 | |
| pharmacology of the ruminant gastroduodenal junction. | 1985 | 2869150 | |
| in situ assembly states of (na+,k+)-pump atpase in human erythrocytes. radiation target size analyses. | the in situ assembly state of the (na+,k+)-pump atpase of human erythrocytes was studied by applying the classical target theory to radiation inactivation data of the ouabain-sensitive sodium efflux and atp hydrolysis. erythrocytes and their extensively washed white ghosts were irradiated at -45 to -50 degrees c with an increasing dose of 1.5-mev electron beam, and after thawing, the na+-pump flux and/or enzyme activities were assayed. each activity measured was reduced as a simple exponential f ... | 1985 | 2414287 |
| tumor angiogenesis inhibition by prostaglandin synthetase inhibitors. | the release of prostaglandins from tumor cells seems to play an important role in tumor angiogenesis, in which platelet-derived factors may be also included. administration of prostaglandin synthetase inhibitors reduces the growth of both experimental and human malignant tumors. one explanation may be reduced tumor vascularization, as observed in microangiographic studies of experimental transplantable tumors. a similar effect was observed after induced thrombocytopenia. a number of angiogenesis ... | 1986 | 2423014 |
| [a study of the antineoplastic activity of k18]. | k18 is a new drug produced by a combination of melphalan and human immunoglobulin. k18 produced an inhibitory effect on the proliferation of human gastric and colon cancer transplanted in to nude mice. also, combination effects of k18 with mmc and 5-fu were recognized in the same system. in a study of distribution after k18 administration, the accumulation and retention of this drug in the tumor region were observed. in the case of melphalan administration, these phenomena were not observed. the ... | 1986 | 2423038 |
| differential translation of the genes encoding the proton-translocating atpase of escherichia coli. | translation of the gene for the b subunit of the escherichia coli proton-translocating atpase has been examined. oligonucleotide-directed site-specific mutagenesis was used to mutate certain nucleotides in the intergenic region between unce (c) and uncf (b). one of the changes was predicted to lower the stability of a proposed stem structure which blocked the ribosome binding site of the uncf mrna segment. the result of the mutation is a nearly 3-fold increase in the rate of synthesis of the b p ... | 1986 | 2873137 |
| differential translation of the genes encoding the proton-translocating atpase of escherichia coli. | translation of the gene for the b subunit of the escherichia coli proton-translocating atpase has been examined. oligonucleotide-directed site-specific mutagenesis was used to mutate certain nucleotides in the intergenic region between unce (c) and uncf (b). one of the changes was predicted to lower the stability of a proposed stem structure which blocked the ribosome binding site of the uncf mrna segment. the result of the mutation is a nearly 3-fold increase in the rate of synthesis of the b p ... | 1986 | 2873137 |
| homocysteic acid, an endogenous agonist of nmda-receptor: release, neuroactivity and localization. | 1986 | 2878563 | |
| the epidemiology of the acquired immunodeficiency syndrome. | 1986 | 3008169 | |
| peptidoglycan synthetic activities in membranes of escherichia coli caused by overproduction of penicillin-binding protein 2 and roda protein. | penicillin-binding protein (pbp)-2 and the roda protein are known to function in determining the rod shape of escherichia coli cells. peptidoglycan biosynthetic reactions that required these two proteins were demonstrated in the membrane fraction prepared from an e. coli strain that overproduced both of these two proteins and which lacked pbp-1b activity (the major peptidoglycan synthetase activity in the normal e. coli membranes). the cross-linked peptidoglycan was synthesized from udp-n-acetyl ... | 1986 | 3009484 |
| pain, increasing girth in healthy japanese man. | 1986 | 3021791 | |
| pain, increasing girth in healthy japanese man. | 1986 | 3021791 | |
| encephalomyocarditis virus 3c protease: efficient cell-free expression from clones which link viral 5' noncoding sequences to the p3 region. | all picornaviral peptides are derived by progressive posttranslational cleavage of a giant precursor polyprotein. translation of encephalomyocarditis virus (emc) rna in rabbit reticulocyte extracts produces active viral peptides, including protease 3c, which is responsible for many cleavage reactions within the processing cascade. dna plasmids containing 5' noncoding sequences of emc linked to other portions of the viral genome were constructed and transcribed into rna. like virion rna, the clon ... | 1986 | 3021972 |
| sequence of the genome ends and of the junction between the ends in concatemeric dna of pseudorabies virus. | the nucleotide sequences of the termini of the mature pseudorabies virus genome and of the junction between these termini in concatemeric dna were compared. to ensure conservation of unmodified 5' and 3' termini, the end fragments obtained directly (uncloned) from mature viral dna were sequenced. the sequence obtained from 5' and 3' end labeling revealed that whereas the l terminus was blunt ended, the s terminus had a 2-base (gg) 3' overhang. the sequences spanning the junction between the term ... | 1986 | 3023670 |
| vectors for expression and amplification of cdna in mammalian cells: expression of rat phenylalanine hydroxylase. | we have constructed two recombinant plasmid vectors for direct expression and amplification of cdna in mammalian cells. each vector carries two dominant selectable markers (the bacterial neo gene and the mouse dhfr gene), a promoter sequence (viral ltr in pav009/a+, and sheep metallothionein promoter in pmt010/a+), a polyadenylation signal sequence, and a bam hi site to allow insertion of cdna. we have used these vectors to prepare recombinant clones for the expression of rat phenylalanine hydro ... | 1986 | 3028740 |
| vectors for expression and amplification of cdna in mammalian cells: expression of rat phenylalanine hydroxylase. | we have constructed two recombinant plasmid vectors for direct expression and amplification of cdna in mammalian cells. each vector carries two dominant selectable markers (the bacterial neo gene and the mouse dhfr gene), a promoter sequence (viral ltr in pav009/a+, and sheep metallothionein promoter in pmt010/a+), a polyadenylation signal sequence, and a bam hi site to allow insertion of cdna. we have used these vectors to prepare recombinant clones for the expression of rat phenylalanine hydro ... | 1986 | 3028740 |
| pharmacokinetics of trimetrexate (nsc 352122) in monkeys. | the pharmacokinetics of trimetrexate was studied in rhesus monkeys following i.v. bolus, continuous i.v. infusion, oral, and subcutaneous administration. two methods were used to measure drug concentration in plasma, cerebrospinal fluid (csf), and urine: the dihydrofolate reductase inhibition assay, and a reverse phase high-pressure liquid chromatography assay. the pharmacokinetic behavior of trimetrexate was characterized by triexponential plasma disappearance, elimination primarily by biotrans ... | 1986 | 2933145 |
| topical mupirocin in the treatment of bacterial skin infections. | mupirocin is an investigational topical antibiotic used for treatment and prophylaxis of bacterial skin infections. mupirocin differs from other antibiotics in its synthesis, structure, and mechanism of action. in vitro, mupirocin possesses antimicrobial activity against staphylococci, streptococci, hemophilus influenzae, and neisseria gonorrhoeae. few studies comparing mupirocin to other topical antibiotics are available. initial studies comparing mupirocin to inactive vehicle in the treatment ... | 1986 | 3102197 |
| topical mupirocin in the treatment of bacterial skin infections. | mupirocin is an investigational topical antibiotic used for treatment and prophylaxis of bacterial skin infections. mupirocin differs from other antibiotics in its synthesis, structure, and mechanism of action. in vitro, mupirocin possesses antimicrobial activity against staphylococci, streptococci, hemophilus influenzae, and neisseria gonorrhoeae. few studies comparing mupirocin to other topical antibiotics are available. initial studies comparing mupirocin to inactive vehicle in the treatment ... | 1986 | 3102197 |
| treatment of endemic goitre with iodine and thyroid hormones, alone or in combination. (preliminary report). | 108 patients with endemic nontoxic goitre have been treated in the field with thyroxine (t4), triiodothyronine (t3), and potassium iodide (ki), singly or in combination, or with placebo. after 6 months of continuous treatment, goitre size decreased significantly in the 7 actively treated groups, but not in the one treated with placebo. the combination of 150 micrograms t4 + 150 micrograms ki daily seemed the most effective treatment, both clinically and by its suppression of the 131i uptake and ... | 1986 | 3486112 |
| short- and long-term effects of angiotensin ii on the rat adrenal zona glomerulosa. a coupled stereological and enzymological study. | long-term angiotensin ii administration induced a time-dependent increase in the volume of rat zona glomerulosa cells and in the plasma concentration of aldosterone. cell hypertrophy is coupled with comparable increases in the surface area per cell of mitochondrial cristae and in the activity per cell of 18-hydroxylase. 11 beta-hydroxylase activity was not affected. these findings allow to suggest that the angiotensin-ii-enhanced growth of rat zona glomerulosa is associated with the de novo synt ... | 1986 | 3493913 |
| right hepatic lobectomy for primary lymphoma: a case report and literature review. | primary lymphoma of the liver is an extremely rare entity; only eight cases have been reported in the literature. we treated a 34-year-old man with primary hepatic lymphoma by right hepatic lobectomy, including right hemicolectomy the nephrectomy. the histological diagnosis was a small cell diffuse histiocytic lymphoma. details of this case plus that of others in the literature are described in this report. | 1986 | 3534401 |
| collagen fiber alignment in the human preauricular dermis before and after rhytidectomy--a scanning electron microscopy study. | the microarchitecture of collagen fibers in preauricular dermis specimens that were obtained during two-phase rhytidectomy were visualized and recorded using the scanning electron microscope. examination of photomicrographs revealed that both spatial arrangement and degree of convolution of the collagen fibers were completely different in the specimens of the two phases. the results are interpreted in terms of the viscoelastic properties of the skin. | 1986 | 3273035 |
| the effect of dietary refined sugars and sugar alcohols on renal calcium oxalate deposition in ethylene glycol-treated rats. | the effect of administering refined carbohydrates in the diet on calcium oxalate deposition in the kidneys of rats given 1% (v/v) ethylene glycol in their drinking-water was investigated. the rats were given 0, 2.5, 10, 30 or 60% sucrose in the feed (w/w) and/or drinking-water (w/v) or 20% (w/w) starch, glucose, sucrose, fructose, galactose, xylitol or sorbitol in the feed for 3 wk. all of the animals remained healthy over the test period as far as could be assessed by the measurement of 19 plas ... | 1986 | 3744193 |
| quantification of interaction between elf-lf electric fields and human bodies. | 1986 | 3744391 | |
| maternal suprachiasmatic nuclei are necessary for maternal coordination of the developing circadian system. | during late fetal and early neonatal life, the maternal circadian system coordinates the timing of a circadian clock in the hypothalamic suprachiasmatic nuclei (scn) to the prevailing light-dark cycle. the role of the maternal scn in the process of maternal coordination was investigated in rats. complete lesions of the maternal scn on day 7 of gestation disrupted rhythms of scn glucose utilization in fetuses and pineal n-acetyltransferase activity in 10-d-old pups. this disruption was probably d ... | 1986 | 3746430 |
| affinity-labeling steroids as biologically active probes of antiglucocorticoid hormone action. | the role of the glucocorticoid receptor in the expression of antiglucocorticoid action has been investigated with a chemically-reactive derivative of three glucocorticoid steroids with differing biological potencies, i.e. the c-21 mesylates of cortisol, dexamethasone and deacylcortivazol. dexamethasone 21-mesylate (dex-mes) was the most useful derivative due to its favorable balance of high receptor affinity and predominantly irreversible antiglucocorticoid activity. a number of criteria have be ... | 1986 | 3754598 |
| comparison of histones in normal and xeroderma pigmentosum lymphoblastoid cells. | histones from normal human and xeroderma pigmentosum, complementation group a (xpa), lymphoblastoid cells were compared both quantitatively, qualitatively and for binding affinity for dna. electrophoretic examination of the histones showed that all five major histone species were present in both cell groups and that there were no quantitative differences between normal and xpa histones. binding affinity to [3h] mammalian dna of the histones was determined. no significant differences were observe ... | 1986 | 3791423 |
| studies on gastric bicarbonate secretion in man by means of a two-component method. | a method for measurement of gastric bicarbonate secretion in man, based on a two-component model of gastric secretion, has been recently described. the results obtained by employing that method for clinical studies are reported and reviewed. | 1986 | 3807470 |
| structural elucidation of a water-insoluble glucan produced by a cariogenic oral streptococcus. | the structure of a water-insoluble polysaccharide produced by the d-glucosyl-transferase of streptococcus mutans 6715 has been elucidated through periodate oxidation, smith degradation, dextranase digestion, concanavalin a binding studies, and methylation combined with g.l.c.-m.s. analysis. these studies show that the d-glucan is comprised of 67% alpha-(1----3) linkages in a contiguous backbone with the remaining 33% as alpha-(1----6) linkages, possibly as linear residues extending from alpha-(1 ... | 1986 | 3815409 |
| in vitro studies with melphalan and pediatric neoplastic and normal bone marrow cells. | chemotherapeutic agents are used in increasingly high dosages to treat patients with refractory cancers. an in vitro clonogenic assay was used to investigate the effects of melphalan on cultures of human neuroblastoma, ewing's sarcoma, and osteosarcoma cells, as well as on normal bone marrow cells. a 1-hr incubation with 10(-5) m melphalan significantly inhibited tumor colony growth of both fresh neuroblastoma and osteosarcoma cells (p less than 0.01) while ewing's sarcoma cells and normal bone ... | 1986 | 3458679 |
| case records of the massachusetts general hospital. weekly clinicopathological exercises. case 29-1986. an asplenic woman with evidence of sepsis and diffuse intravascular coagulation after a dog bite. | 1986 | 3724816 | |
| recessive dystrophic epidermolysis bullosa. evidence for increased collagenase as a genetic characteristic in cell culture. | fibroblast cultures from patients with recessive dystrophic epidermolysis bullosa (rdeb) demonstrated an increased capacity to synthesize and secrete collagenase. this phenotypic trait appeared to distinguish rdeb from other genetically distinct forms of epidermolysis bullosa. the finding of increased collagenase may be a specific manifestation of these cells in that prototypic lysosomal and cytoplasmic enzymes were present in approximately normal concentrations. in addition, this trait persiste ... | 1986 | 214508 |
| possible role of protein phosphorylation in the mitogenic effect of high density lipoproteins on cultured vascular endothelial cells. | the implication of protein phosphorylation in the mitogenic action of high density lipoproteins (hdl) on bovine vascular endothelial cells was investigated by incubating endothelial cell cultures in the presence of 32p-labeled phosphoric acid. the incorporation of 32p into proteins was measured after fractionation by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate and autoradiography of the gel. in endothelial cells seeded at low density and made quiescent by serum s ... | 1986 | 3486870 |
| isotope exchange at equilibrium studies with rat muscle adenylosuccinate synthetase. | the kinetic mechanism of rat muscle adenylosuccinate synthetase was studied by determining the rates of isotope exchange at equilibrium. a random sequential binding mechanism was indicated for both the forward and reverse reactions. aspartate, adenylosuccinate, gdp, and pi were determined to bind in rapid equilibrium. gtp exchanges with both gdp and pi at the same rate, which is similar to the exchange rate of imp with adenylosuccinate. aspartate exchanges with adenylosuccinate at a higher rate ... | 1986 | 3542024 |
| creativity in the life and work of karl menninger, m.d.. interview by paul w. pruyser. | 1986 | 387142 | |
| pulp protection in restorative procedures. | 1986 | 1075483 | |
| preliminary experience with 15 (s) 15-methyl prostaglandin f2 alpha for midtrimester abortion. | twenty-six women received intramuscular or intra-amniotic 15 (s) 15-methyl prostaglandin f2 alpha to induce midtrimester abortion. the median initial injection-abortion interval was 10 hours and 25 minutes. the advantages of intramuscular analogue are somnolence and reduced discomfort during labor. disadvantages include severe gastrointestinal toxicity in the majority of patients and symptoms of acute respiratory distress in two patients. | 1986 | 1146878 |
| spectroscopic studies on invertebrate myosins and light chains. | 1986 | 215199 | |
| effectiveness of the nitroblue tetrazolium test in demonstrating reduced bactericidal activity of polymorphonuclear neutrophils in schistosomal hepatosplenomegaly and ascites. | the nitroblue tetrazolium (nbt) test was carried out on blood from ten normal individuals and 20 schistosomal patients, ten of whom had hepatosplenomegaly and ten hepatosplenomegaly and ascites. the test revealed defective neutrophils in patients who had hepatosplenomegaly accompained by ascites. the phagocytic and bactericidal effects from five of each of the two groups of patients; results substantiated tose obtained by the nbt screening test. the nbt screening test thus proved useful in detec ... | 1986 | 1146763 |
| [senior citizen-movement; self help organization of the older generation]. | 1986 | 214634 | |
| hereditary fructose intolerance: a difficult diagnosis in the adult. | 1987 | 213970 | |
| the effects of reserpine on hypothalamo-pituitary adrenocortical function. | 1987 | 212345 | |
| department of health and human services, public health service, national institutes of health. recombinant dna advisory committee. minutes of meeting, september 29, 1986. | 1987 | 3475740 | |
| evaluating rapid tests for streptococcal pharyngitis: the apparent accuracy of a diagnostic test when there are errors in the standard of comparison. | the evaluation of new rapid antigen detection tests for streptococcal pharyngitis is complicated by the presence of errors in the standard of comparison. even "gold standard" throat cultures are not perfectly accurate. this article is an analysis of how errors in the comparison cultures affect the apparent accuracy of new tests for streptococcal pharyngitis. one of the questions addressed is whether throat cultures performed in a physician's office are accurate enough to use as a standard in a c ... | 1987 | 3553828 |
| effects of tilomisole, indomethacin and levamisole on regulation of epstein barr virus-induced b cell proliferation by peripheral blood mononuclear cells from normal individuals and patients with rheumatoid arthritis. | when activated in autologous mixed leukocyte reactions (auto-mlr) in vitro, t cells from normal individuals produce a suppressor factor(s) which inhibits the epstein-barr virus (ebv)-induced proliferation of normal b cells. in contrast, t cells from patients with rheumatoid arthritis (ra) are deficient in their ability to generate this suppressor factor in auto-mlr. addition of tilomisole (wy-18,251; 33(p-chlorophenyl)thiazolo[3,2-a]benzimidazole-2-acetic acid) to the auto-mlr (0.1-100 microgram ... | 1987 | 2825478 |
| invasiveness, metastasis, and transplantability of mouse liver nodules. | data are presented which show that various mouse liver nodular lesions, such as hyperplastic nodules, hepatocellular adenomas, and hepatocellular carcinomas, differ not only morphologically but also biologically regarding their behavior in the primary and secondary hosts. the hyperplastic nodules grew slowly by expansion without affecting the integrity of the lobular structure. the primary hepatocellular adenomas also grew slowly by expansion but eliminated the histoid liver structure. neither l ... | 1987 | 3472500 |
| complement component deposition in uteroplacental (spiral) arteries in normal human pregnancy. | there is conflicting evidence for the deposition of complement in spiral arteries in normal and abnormal human pregnancies. the immunogold silver staining (igss) technique was used to investigate the distribution of c1q, c3d, c4, c6 and c9 within the spiral arteries of formalin-fixed normal pregnancy hysterectomy specimens ranging in gestational age from 4 to 40 weeks. deposition of complement components studied was observed in all cases suggesting classical pathway activation. reactivity was no ... | 1987 | 3430480 |
| tumor necrosis factor is partly responsible for the differentiation of mouse myeloid leukemia cells. | when mouse myeloid leukemia m1 cells were incubated with 0.1% tns(serum containing tumor necrosis factor, tnf), they were induced to differentiate into macrophage-like cells within 14 h. the stability of the differentiation activity to heat treatment was very similar to that of the cytotoxicity of tnf for l929 cells. the differentiation activity could not be separated from the tnf activity by sequential chromatography procedures using deae-sephadex and sephacryl s-200 or by isoelectric focusing. ... | 1987 | 3440028 |
| cytoplasmic gels from macrophages. evidence for the involvement of four proteins in the calcium-dependent solation of actin networks. | a method has been devised to study the influence of ca2+ on the in vitro formation of actin gel networks. under appropriate conditions low-ca2+ cytosolic extracts (less than 1 nm) from macrophages rapidly formed a macromolecular complex composed of actin, filamin, alpha-actinin and two new proteins of 70 kda and 55 kda. [pacaud, m. (1986) eur. j. biochem. 156, 521-530]. increasing concentrations of free ca2+ to 1-2 microm resulted in complete inhibition of the association of 70-kda protein, a pr ... | 1987 | 3569290 |
| cytocidal and toxic effect of various cytostatic drugs on three ascites tumors of the mouse. | the cytocidal and toxic effects of four cytotoxic drugs (cy, ddp, vcr, ara-c) were studied using three types of ascites tumors (l 1210, jb-1, eat) growing on three different mouse strains (b6d2f1, akr, nmri). there were considerable differences in the cytocidal effect of the same dose of each drug on the three tumor cell lines; 100% of the l 1210 ascites tumor-bearing animals were permanently cured by a high dose of cy (300 mg/kg) and 30% by ddp (13 mg/kg), while most of the jb-1 and all eat-bea ... | 1987 | 3584212 |
| cytocidal and toxic effect of various cytostatic drugs on three ascites tumors of the mouse. | the cytocidal and toxic effects of four cytotoxic drugs (cy, ddp, vcr, ara-c) were studied using three types of ascites tumors (l 1210, jb-1, eat) growing on three different mouse strains (b6d2f1, akr, nmri). there were considerable differences in the cytocidal effect of the same dose of each drug on the three tumor cell lines; 100% of the l 1210 ascites tumor-bearing animals were permanently cured by a high dose of cy (300 mg/kg) and 30% by ddp (13 mg/kg), while most of the jb-1 and all eat-bea ... | 1987 | 3584212 |
| differential examination of bronchoalveolar lavage cells in tobacco cigarette and marijuana smokers. | cells derived from bronchoalveolar lavage (bal) were obtained from 19 healthy non-smokers (ns) and from 43 healthy smokers of tobacco and/or marijuana. thirteen subjects smoked tobacco cigarettes only (ts) (mean +/- se: 17.4 +/- 5.5 pack-years). thirty subjects smoked marijuana; of these, 14 smoked marijuana only (ms) (149.1 +/- 102.7 joint-years) and 16 smoked marijuana and tobacco (mts) (43.3 +/- 7.2 joint-years and 18.4 +/- 3.2 pack-years). cell counts were expressed as total number recovered ... | 1987 | 3592403 |
| differential examination of bronchoalveolar lavage cells in tobacco cigarette and marijuana smokers. | cells derived from bronchoalveolar lavage (bal) were obtained from 19 healthy non-smokers (ns) and from 43 healthy smokers of tobacco and/or marijuana. thirteen subjects smoked tobacco cigarettes only (ts) (mean +/- se: 17.4 +/- 5.5 pack-years). thirty subjects smoked marijuana; of these, 14 smoked marijuana only (ms) (149.1 +/- 102.7 joint-years) and 16 smoked marijuana and tobacco (mts) (43.3 +/- 7.2 joint-years and 18.4 +/- 3.2 pack-years). cell counts were expressed as total number recovered ... | 1987 | 3592403 |
| effect of protein starvation on protein turnover in liver, oviduct and whole body of laying hens. | 1. whole body protein turnover rates in white leghorn laying hens were reduced by protein starvation for 7 days, followed by complete restoration by protein repletion for 7 days. 2. protein starvation considerably reduced fractional and absolute rates of protein synthesis both in the liver and, to a greater extent, in the oviduct. 3. it was suggested that a considerable portion of the reduced whole body protein synthesis could be accounted for by the reduced protein synthesis in these organs whe ... | 1987 | 3621897 |
| cytotoxic escherichia coli. | 1987 | 3305326 | |
| effects of endotoxemia on pulmonary vascular resistances in unanesthetized sheep. | ten experiments were conducted on nine sheep to determine the effects of endotoxemia (1.0 microgram/kg iv over 15 min) on the vascular resistances of two segments of the pulmonary circulation. the first segment (s1) was from the main pulmonary artery to the site in the pulmonary veins corresponding to the pressure measured with a deflated and wedged 7-fr swan-ganz catheter. the second segment (s2) was from the wedge pressure measurement site to the left atrium. endotoxemia caused both pulmonary ... | 1987 | 3308813 |
| comparison of human growth hormone levels in children with satisfactory and unsatisfactory growth. | sixty-six children with satisfactory growth and 73 with unsatisfactory growth (both sexes) from three different age groups (1 year, 5 years and 10 years) were included in this study. it was observed that the serum concentrations of human growth hormone (hgh) in children with satisfactory growth ranged from 1.00 to 4.00 ng/ml and never exceeded 4.00 ng/ml. in a comparative study there was a significant increase in serum hgh levels in subjects of all age groups who were not growing satisfactorily. ... | 1987 | 2956220 |
| human milk-derived lactoferrin inhibits mitogen and alloantigen induced human lymphocyte proliferation. | purified lactoferrin (lf), isolated from human milk, was tested for its effect on human t-lymphocyte proliferative responses to phytohemagglutinin (pha) and to alloantigens in mixed lymphocyte culture. lf inhibited proliferation in both assays in a dose-dependent manner. the suppressive effect was not due to lf mediated cytotoxicity since washing cells that had been pre-incubated with lf restored their proliferative activity. lf was most effective in suppressing the pha response when added withi ... | 1987 | 2963123 |