cellular factors. immunologic tolerance: irradiation and bone marrow transplantation in induction of canine allogeneic unresponsiveness. 197717203
[acid-base equilibrium in mother and fetus during labor and the resistance of newborn calves].investigated were a total of 59 cows presenting normal processes, of giving birth as well as dystocia, the time of delivery lasting 2, 10, 24, and 36 hours. seventeen cows with dystocia were treated intravenously with 500 cm3 of a 4 per cent solution of sodium bicarbonate and 40 g glucose. it was found that the changes in the ph values, alkali reserves, glycogen, and the peroxydase activity of the neutrophiles in the mothers and fetuses were dependent on the duration of parturition. cases of dif ...197834922
[skin disease in cattle, caused by dermatophilus congolensis]. 197553909
antimicrobial susceptibility of vibrio cholerae from zaire and rwanda. 197990940
cell-free synthesis and segregation of beta 2-microglobulin.beta2-microglobulin has been synthesized in vitro by using a rabbit reticulocyte lysate system and mrna from the mouse tumor cell line el4. the molecule is synthesized as a precursor with an nh2-terminal extension of 19 amino acids: ser-x-ser-val-x-leu-val-phe-leu-val-leu-val-ser-leu-x-gly-leu-tyr-x. the processing and segregation of this peripheral membrane protein are directly comparable to those of secretory proteins and integral membrane proteins: addition of dog pancreas microsomal membrane ...197991168
the zinc-iodide-osmium technique in studies of the neurosecretory system in rats. 197991310
the murine kupffer cell. i. characterization of the cell serving accessory function in antigen-specific t cell proliferation.murine kupffer cells, the tissue macrophages of the liver, were isolated by collagenase digestion, differential sedimentation over metrizamide, and glass adherence. the resultant cell population was more than 86% phagocytic, and 95% of cells stained positively for alpha-naphthyl butyrate esterase activity. the cells also had cell surface receptors for complement (c) and the fc portion of igg. in addition, a large proportion of kupffer cells was shown to bear ia antigens: about half of the cells ...197991637
[orthosympathetic stimulation after hypercapnia in the rat].inhalation of a gas mixture : co2, 25% -- o2, 37.5% -- n2, 37.5%, provokes regularly in the light anaesthetized rat, an increase of catecholaminemia of central origin, associated with systemic arterial hypertension.197992225
evidence for reappearance of trypanosoma brucei variable antigen types in relapse out of 11 bovines infected with different clones of trypanosoma brucei showed 2 peaks of antibody activity against the infecting clone within 7 weeks, as measured by immunofluorescence, radioimmunoassay, and neutralization of infectivity tests. using other clones from an unrelated stock, antibodies to these clones were not detectable, indicating that the antibodies produced were specific to the infecting organisms. these results suggest that there was a reappearance or increase in numbers ...197992560
the accessibility of antigenic determinants of ribosomal protein s4 in situ.antibodies to escherichia coli ribosomal protein s4 react with s4 in subribosomal particles, eg, the complex of 16s rna with s4, s7, s8, s15, s16, s17, and s19 and the ri reconstitution intermediate, but they do not react with intact 30s subunits. antibodies were isolated by three different methods from antisera obtained during the immunization of eight rabbits. some of these antibody preparations, which contained contaminant antibodies directed against other ribosomal proteins, reacted with sub ...197992615
aberrant form of hymenolepis nana: possible opportunistic infection in immunosuppressed patients. 197992715
the carbohydrate content of apolipoprotein e from human very low density lipoproteins. 197992742
delayed hypersensitivity to chlamydia trachomatis: cause of chronic prostatitis. 197993221
reverse transcriptase-associated rnase h. part iv. pyrophosphate does not inhibit rnase h activity of amv dna polymerase. 197993479
the fine specificity of regulatory t cells. iv. idiotypic complementarity and antigen-bridging interactions in the anti-lysozyme response.the hen egg-white lysozyme (hel)-specific b cells which are activated in response to hel share a cross-reactive idiotype as well as submolecular specificity. helper t cells of two different specificities are implicated in their optimal activation, one recognizing the idiotype and the other, an epitope on the hel molecule opposite to the one recognized by b cells. thus, efficient t-b collaboration involves both idiotypic complementary and antigen bridging.197993548
[purification and characterization of the free secretory piece of human colostrum (author's transl)].the free secretory piece is isolated from human colostrum by gel filtration and ion-exchange chromatography in high yield (200 mg/l colostrum). deae-cellulose chromatography separates the free secretory piece in two fractions which are electrophoretically distinct, but otherwise have the same characteristics, like molecular weight, antigenic determinants, n-terminal sequence, peptide map and amino acid composition. it was therefore concluded that the protein part of the secretory piece is homoge ...197993565
chlorpyrifos and 3,5,6,-trichloro-2-pyridinol: residues in the body tissues of cattle wearing chlorpyrifos-impregnated plastic ear tags. 197993609
substance p as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation. 197993706
preferential replication of murine xenotropic type-c virus in human lymphosarcoma-derived cell lines.murine xenotropic virus, designated 698/x, was recovered by implantation of human lymphosarcoma-derived cells u-698m into nude mice of giovanella's colony. the budded and extracellular particles revealed typical type-c morphology, the latter possessing reverse transcriptase (rt) activity and exhibiting a buoyant density 1.17 g/ml in sucrose gradient. in competitive radioimmunoassay using iodinated p30 of rauscher mulv, the 698x viral concentrate and cell extracts of both implanted lymphosarcoma ...197993707
has myelin basic protein received a fair trial in the treatment of multiple sclerosis?autosensitization to some central nervous system antigen still remains one of the best hypotheses for the continuing pathogenesis of multiple sclerosis (ms). enough is now known about the cause, pathogenesis, and treatment of experimental allergic encephalomyelitis (eae) to test this hypothesis. reports of therapeutic failure of the encephalitogen myelin basic protein (bp) in the treatment of ms have their counterparts in similar therapeutic failures in eae. only highly inbred strain 13 guinea p ...197993873
influence of atropine on spontaneous or catecholamine-induced arrhythmias after experimental infarction in the dog.the effects of atropine on ventricular tachyarrhythmias induced by ligature of the anterior descending coronary artery were studied in conscious dogs. on the first day after surgery, animals received a mixture of quinidine and phenytoin orally in order to partially correct rhythm disturbances on the second day. the same animals were used on the third and fourth days after occlusion, when spontaneous regression of arrhythmias was occurring. atropine (0.2 mg/kg i.v.) or methscopolamine (0.2 mg/kg ...197994403
[prognostic value of alpha-foetoprotein in fulminant hepatitis (author's transl)].serum concentrations of alpha-foetoprotein (afp) were measured sequentially by radioimmunoassay in 32 patients with fulminant hepatitis and coma, 22 of whom died. levels were significantly elevated in 100% of patients who survived and in 7 out of 22 patients (38.5%) who died (p = less than 0.005). in the survivors the rise of afp levels was found early after the development of coma and subsequently in all serum samples obtained during acute phase of illness. in 2 of 7 fatal cases who had raised ...197994446
neovasculogenesis. triggering factors and possible mechanisms.the possible regulating mechanism(s) of neovascularization are discussed. experimental data supporting the view that ocular neovascularization might be triggered by a fundamental metabolic mechanism are presented. based on his own data and scattered evidence from the literature, the author suggests a model for a possible regulating mechanism of the neovascular process in which the prostaglandins fulfill the role of neovascular mediating substances. preliminary results demonstrating that indometh ...197994468
the role of antigen-specific t cell factors in the immune response. 197994504
factors involved in the age-dependent resistance of mice infected with low-virulence mouse hepatitis virus.four-week-old weanling mice survived, whereas 1-week-old suckling mice died, after intraperitoneal inoculation of mouse hepatitis virus, mhv-s strain. the factors involved in this difference in susceptibility were studied. after virus inoculation, differences in virus growth in the liver and spleen were observed, which correlated with the susceptibility of animals to the virus. interferon, detected at an early stage of infection, was considerably lower in suckling mice than in weanling mice. tit ...197994538
[characteristics of human dental pulp cells in cell cultures].the generation time and the division rate were measured with routine methods of cell culturing. the conditions contributing to the stagnation of growth were examined; the synchrony of the growth process was investigated. the biochemical composition of the cells was assessed via colorimetry and then compared with other cell systems. the cell culture examined may be used to test capping materials; only cells up through the eighth generation however should be utilized.197994854
on the pharmacology of venous smooth muscle from dog and man.changes in tension of spiral strips from canine and human veins induced by various drugs are compared with results from the literature on human veins. the order of potencies of alpha-adrenoceptor stimulating amines (adrenaline greater than noradrenaline greater than dopamine greater than isoprenaline) is similar in human and canine veins. comparison of the affinities for alpha-adrenoceptors of pharmacologic drugs (thymoxamine, indoramine, clonidine, dihydroergotamine) suggest marked differences ...197994863
pyrazolidine derivatives: a comparative study of their effects on platelet aggregation.quantitative studies were carried out of the in vitro and ex vivo effects of phenylbutazone and 3-oxoalkyl substituted diphenyldioxopyrazolidines (kebuzone, tribuzone, benzopyrazone) on platelet aggregation. the specified pyrazolidine derivatives exhibited in vitro inhibitory effects on secondary platelet aggregation (induced by adrenaline and collagen), commensurable with the effects of sulfinpyrazone. the ex vivo efficacy was markedly influenced by the height of the drug level in blood and by ...197994876
staining with chromoxane cyanine r.since pearse in 1957 introduced chromoxane cyanine r as a dual nuclear and cytoplasmic stain there have appeared numerous procedures for use of this dye. these have differed widely, sharing in common mainly the implication that each is best. a defendable procedure has been developed on an experimental basis and is reported here. four stock solutions are needed: (1) a 0.2% solution of chromoxane cyanine r in 0.5% aqueous h2so4 (v/v); boil this solution for 5 min, (2) 10% fecl3 in 3% hcl, (3) 1% a ...197994954
the effect of cyclophosphamide on a secondary ocular immune response in rabbits.treatment of rabbits with immunosuppressive doses of cyclophosphamide during the primary response to intravitreally injected bovine gamma globulin did not prevent priming for a secondary response to the same antigen. high antibody titers were found in the aqueous humor and serum of most of the treated rabbits. ocular tissue plaque forming cell numbers were similar to those of the controls in many of the rabbits, and slightly lower in others. treatment with cyclophosphamide completely suppressed ...197994972
[hepatitis b virus during pregnancy and its consequences in perinatology]. 197995065
visualization of mitochondrial coupling factor f1(atpase) by is known that the negatively stained preparations of inner mitochondrial membrane display characteristic approximately 9 nm f1 (atpase) knobs projecting from the matrix surface. freeze-etch studies have reported the absence of such knobs from the "etched" surface of the inner mitochondrial membranes. we have demonstrated their presence on the surface of smp (submitochondrial particles) prepared by freeze-drying for transmission electron microscopy. this identification has been substantiated b ...197995168
world veterinary manpower: comparative aspects.the number of veterinarians in relation to livestock units, human population, milk and meat production and gross national product for 93 countries is presented. the structure of veterinary manpower is discussed and information on veterinary involvement with companion animals and public health is given. for 23 countries representing all the continents, the number of livestock units, human population and gross national product per veterinary school are presented.197995360
dextran anaphylactoid reaction in sprague-dawley cfy rats.from a closed colony of randomly-bred sprague-dawley cfy rats about 23% failed to respond to intravenous dextran with the characteristic generalized anaphylactoid reaction, but still exhibited an inflammatory response when dextran was given into the foot pad. brother-sister mating of rats showing the most expressed generalized reaction (reactor rats) yielded good responder offsprings, while the non-reactors had descendants completely unresponsive to systemic dextran. brother-sister mating of sel ...197995467
[ultrastructural aspects of keratinization of the rat oral mucosa. iii. gums (author's transl)]. 197995578
photobehavior of microorganisms: a biophysical approach. 197896724
studies on the occurrence of peptococcus indolicus and corynebacterium pyogenes in abscesses in swine, and on the occurrence of pc. indolicus in apparently normal skin and mucous membranes of piglets.pc. indolicus was isolated from 42.7% and cb. pyogenes from 48.7% of 150 pus-samples from abscesses in pigs (slaughter-house material, table i). in 41 specimens the two organisms were found together. further, pc. indolicus was demonstrated in 22.4% of 290 swabs from apparently normal skin and mucous membranes of piglets (autopsy material, table ii). by gel diffusion analysis the strains of pc. indolicus were referred to the serotypes b, c, d, e, or f. the type distribution (table iii) possibly r ...197898755
production and chemical studies of protease from bacillus subtilis (sh-6) egyptian strain.bacillus subtilis (sh-6) egyptian strain, isolated from hides, gave the highest protease activity. luxurious growth and protease production were obtained by the use of a medium containing 8% of potato starch, 0,1 m of ammonium phosphate as carbon and nitrogen sources. results indicate that borate buffer exerted a deleterious effect on the protease production. comparing citrate and phosphate buffers, it was found that citrate gave lower protease activity than phosphate. there is a positive respon ...197898932
biological variation of immunoglobulin concentrations in normal human tears related to age and sex.single radial immunodiffusion method was used to measure the concentration of igg, iga, igm and igd in tears of 220 healthy individuals aged from 2 to 86 years. relation of the values to age and sex has been evaluated statistically by regression analysis method. mean iga level was 30.7 mg/100 ml. igg could be detected in 200 samples and the level was less than 1 mg/100 ml. igm was detected in only 7 samples and the value was less than 1 mg/100 ml. igd could not be detected in any of the sample. ...197898956
[transplantation of langerhans' islands]. 197899549
ineffectiveness of prophylactic intrathecal methylprednisolone in myelography with aqueous media.the effectiveness of prophylactic intrathecal methylprednisone (mp) in preventing arachnoiditis from iocarmate myelography was studied. monkeys were injected intrathecally with locarmate, mp, or a combination of the two. twelve weeks later the severity of arachnoiditis was determined in each animal. there was no significant prophylactic effect of intrathecal mp on arachnoiditis from locarmate. some arachnoiditis was found in control animals treated with mp alone.197899764
the isolation and partial characterization of the serum lipoproteins and apolipoproteins of the rainbow trout.1. vld (very-low-density), ld (low-density) and hd (high-density) lipoproteins were isolated from the serum of trout (salmo gairdneri richardson). 2. each lipoprotein class resembled that of the human in immunological reactivity, electrophoretic behaviour and appearance in the electron microscope. trout ld lipoprotein, however, was of greater density than human ld lipoprotein. 3. the trout lipoproteins have lipid compositions which are similar to those of the corresponding human components, exce ...1978100102
restricted posterior parietal lesions in the rhesus monkey and performance on visuospatial tasks.monkeys with lesions restricted to the inferior parietal lobule or the banks and depths of the superior temporal sulcus were tested on a route-following task. these areas are considered on neuroanatomical grounds to be homologous to parts of the human posterior parietal cortex, where lesions produce profound spatial disorientation. the operated monkeys were impaired on the route task, thus confirming at the behavioural level the anatomical predictions of comparability between parietal cortex in ...1979103604
transfer of polychlorinated biphenyls from mothers to foetuses and infants. 1978103790
production of anti-antipyrine antibody by immunization with 4-azoantipyrine-conjugated bovine serum albumin. 1978103791
[isolation of treponemas from the colon of pigs with clinical dysentery].optimal culture conditions in artificial nutritive media were determined for a defined avirulent strain of treponema hyodysenteriae and for four field strains of treponemas in pigs with clinical dysentery. the treponemas were isolated with the use of milliporous filters with pores of 0.3 micrometer in diameter, which were located on the surface of blood agar. no significant difference in the influence of equine, bovine or sheep blood on the growth of treponemas was determined. the commercial amo ...1979105448
vestibular effects of electrical stimulation of the cochlea. monitored in the awake primate.the effect of electrical stimulation of the cochlea on vestibular response was monitored in six rhesus monkeys. eye movements and single-unit activity from the vestibular portion of the eighth nerve, vestibular nuclei, reticular formation, and abducens nucleus were observed while electrical stimulation was delivered through an implanted cochlear prosthesis. in one animal of this series, neural activity from the inferior colliculus and cochlear nuclear complex was also recorded. electrical stimul ...1979106814
[role of the raphe magnus nucleus in morphine analgesia : studies with intracerebral microinjections in the rat].microinjections of low concentration of morphine (5 micrograms) into the nucleus raphé magnus of the rat produce a strong analgesia that can be reversed by systemic naloxone, an opiate antagonist. the administration of naloxone (5 micrograms) into the raphé magnus considerably reduces the effects of intravenous morphine. the effects of microinjections of morphine are strongly reduced by cinanserin, suggesting a role for serotoninergic mechanisms in morphine analgesia.1978106979
primary meningococcal conjunctivitis in an infant.a case of primary meningococcal conjunctivitis in an infant was presented and its treatment is discussed. because of the potential for systemic spread of the infection in the patient, local and systemic therapy was instituted. the current literature on meningococcal conjunctivitis with its potential complications is briefly reviewed.1979106998
the subicular cortex of the cat: an anatomical and electrophysiological study. 1979107038
glycogen synthase kinase-2 from rabbit skeletal muscle is activated by the calcium-dependent regulator protein. 1979107045
antibodies against measles antigen in the laboratory housed rhesus and bonnet monkeys. 1979107117
localization of neurons supplying the temporalis muscle in the rat and monkey.following injection of horseradish peroxidase (hrp) solution into the rat and monkey temporalis muscle, a similar pattern of nuclear representation was found in the motor trigeminal nucleus. labelled neurons were seen throughout the rostro-caudal extent of the ipsilateral motor trigeminal nucleus, in its dorsal, intermediate and ventral portions and its dorsomedial, ventromedial and ventrolateral corners. in addition to the motor trigeminal nucleus labelled neurons were also found in the ipsilat ...1979107492
glycosaminoglycans and acidic glycoproteins in rabbit uterus under estrogenic conditions.uterine slices obtained from the estrogen-treated rabbits were digested with pronase. glycosaminoglycans and acidic glycopeptides were then isolated by dowex 1 column chromatography and preparative electrophoresis on cellulose acetate membrane (separax), in succession. each subfraction thus obtained was identified by the mobility on separax electrophoresis and the digestibility with mucopolysaccharidases (streptomyces hyaluronidase, testicular hyaluronidase, chondroitinase ac, chondroitinase abc ...1975126700
[effect of some antidiuretic agents on the polyuria-polydipsia provoked by alcohol].the authors have studied in the dog--normal or diabetic insipidus after hypothalamic lesion--submitted to oral ingestion of ethanol the effects of a few antidiuretic drug: chlorpropamid, atromid-s, carbamazepin and carisoprodol. the carisoprodol only can reduce the diuresis and the drinking provoked by ethanol.1975126784
[effect of bay 2222 in the "pour-on" method on dictyocaulus and trichostronglides in cattle]. 1975127580
[study of the incorporation of radioactive zinc in saccharomyces cerevisiae aldolase].saccharomyces cerevisiae aldolase concentrates from the culture medium containing znso4 a large amount of zn which becomes a component part of the enzyme molecular structure. this was made evident by adding to the culture medium 65znso4 and measuring the radioactivity of the aldolase extracted by a phillips single channel analyzer.1976133445
hyperactivity induced by tetrahydroisoquinoline derivatives injected into the nucleus accumbens.several derivatives of tetrahydroisoquinoline were injected bilaterally into the nucleus accumbens of rat 2 h after a nialamide pretreatment and activity recorded in cages fitted with photocells. 1,2,3,4-tetrahydroisoquinoline, 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline, 1,2,3,4-tetrahydro-6,7-dihydroxy-1-(3,4-dihydroxybenzyl)-isoquinoline (tetrahydropapaveroline) and 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline caused virtually no change in locomotor activity and 2-methyl-1,2,3,4-tetrahydrois ...1976134899
[super-selective cerebral angiography. iii. diagnostic use and therapeutic possibilities of the telescopic catheterization technic in the circulation area of the external carotid artery in man].the diagnostic value and technical versatility of the previously described telescopic catheter system was demonstrated in 15 patients by super-selective angiography of the external carotid artery. it was possible in all patients to catheterise the individual branches with the f-catheter; the polyethylene-s-catheter could then be passed 3 to 5 cm, beyond the tip of the f-catheter. in almost half the patients, spasm of the injected artery was observed, particularly of the superficial temporal and ...1976134945
suppressor cells in the spleen of tumor-allosensitized mice.c57bl/6 mice were sensitized i.p. with 20 x 10(6) p-815 mastocytoma cells. spleen and lymph node cells from these tumor-allosensitized mice become hyporesponsive in mixed-lymphocyte culture. the hyporesponsiveness appears to be due to the presence of suppressor cells. these suppressor cells can be demonstrated by their ability to inhibit the mixed-lymphocyte culture reactivity of normal mouse spleen cells. suppressor activity in the spleen of tumor-allosensitized mice remains long after cytotoxi ...1977141979
fluorescence of human liver alanine aminopeptidase.fluorescence of human liver alanine aminopeptidase has been attributed to tryptophan fluorescence. the fluorescence maximum is at 330 nm, 20 nm lower than that for free tryptophan, suggesting that most of the enzyme tryptophans are in a nonpolar environment and are shielded from solvent. quenching of enzyme fluorescence by iodide, pyridine, and n-methyl nicotinamide also demonstrates that enzyme tryptophan residues are largely buried and inaccessible to solvent. those accessible are in negativel ...1977143669
effect of cortisone on aspartate and alanine aminotransferases in a desert lizard.1. liver and serum aspartate aminotransferase (got) and alanine aminotransferase (gpt) activities were measured in a hibernating desert lizard, uromastix hardwickii. the levels of both enzymes were found to be lower in hibernation than during the active period, particularly in the liver. 2. after intramuscular injection of 2 mg of cortisone acetate there was a rapid rise in the levels of these enzymes with a peak of 18 hours (got) and 12 hours (gpt). 3. the response of both enzymes to cortisone ...1978149452
studies of the mechanisms for the induction of in vivo tumor immunity. iv. enhancement of the in vitro generation of secondary cell-mediated cytotoxic response by normal peritoneal macrophages and their culture supernatants.the effect of macrophages on the induction of the cell-mediated cytotoxicity against a leukemia in a syngeneic system was investigated. the addition of exogenous peritoneal cells from normal c57bl/6 mice enhanced the in vitro secondary cell-mediated cytotoxic response of both spleen and lymph node cells as responding cells against syngeneic fbl-3 leukemia. peritoneal phagocytic macrophages seemed to be responsible for the enhancement. no inhibitory effect was demonstrated by the addition of peri ...1979156217
persistent or slow viral infections and related diseases.the discovery of persistent transmissible agents by veterinarians has led to striking advances in the infectious cause of neuropathies of human beings. there is evidence for persisting infection in congenital rubella and the herpes group of viruses including cytomegalovirus infections. hepatitis types a and b are candidates for inclusion in the category of persisting viral infections. the rubeola or measles virus is established as a persistent virus which causes elevated antibodies in the serum ...1975165638
nitric oxide complexes of cytochrome p-450. 1975166885
structure of a 30 s pre-ribosomal rna of e. coli. 1975169158
rubrospinal effects on ventral spinocerebellar tract neurones.stimulation of the contralateral red nucleus evoked monosynaptic epsps in 14 of 82 ventral spinocerebellar tract neurones. in some of these cells the monosynaptic epsp was followed by a disynaptic ipsp. the remaining cell population received di- or polysynaptic psps from the rubrospinal tract, either epsps or ipsps or both. convergence of the rubrospinal tract onto interneurones of the segmental pathways projecting to vsct cells was demonstrated. rubrospinal volleys facilitated disynaptic ia ips ...1976176875
tight-skin, a new mutation of the mouse causing excessive growth of connective tissue and skeleton.a new dominant mutation, tight-skin (tsk), is located on chromosome 2, two recombination units distal to pallid (pa). heterozygotes (tsk/+) have tight skins with marked hyperplasia of the subcutaneous loose connective tissues, increased growth of cartilage and bone, and small tendons with hyperplasia of the tendon sheaths. in the loose connective tissue there are large accumulations of microfibrils in the intercellular space. in spite of the increased skeletal size, body weight is not increased. ...1976176891
the effects of metiamide and h1 receptor blocking agents on anaphylactic response in guinea-pigs.the effects of metiamide and of four h1 receptor blocking agents (mepyramine, promethazine, clemastine and ketotifene) on anaphylactic reaction were studied in the guinea-pig. the h1 blockers conferred partial protection which shows that with the experimental protocol utilized (challenge injection with high doses of antigen), histamine plays a lesser role than other mediators released or synthesized. metiamide (30.0 mg/kg i.v.) noticeably enhanced the increase in pulmonary resistance observed du ...197994763
correlation between hepatic transport of cholephilic organic anions and their effect on hepatic mitochondrial respiration.the maximum biliary excretion rate (tm) of some nonmetabolized organic anions was investigated in anaesthetized male rats and was found to increase in the following order: indocyanine green (icg), rose bengal (rb), bromsulphthalein (bsp; its conjugation with glutathione was prevented by diethyl maleate), bromcresol green (bcg), eosine (e), bsp-glutathione conjugate (bsp-gsh), iodoxamic acid (ia) and amaranth (a). the accumulation of icg, rb, bsp and bcg in liver was relatively high, whereas e, b ...197994737
17 alpha estradiol: separation of estrogen effect on collagen from other clinical and biochemical effects in rodents the effect of 17alpha estradiol upon collagen is identical to that of 17beta estradiol, but the 17alpha estradiol effect upon uterine lining is 1/1000 that of 17beta estradiol. both steroids reverse the effect of d-penicillamine on rodent skin collagen. five human beings with the skin collagen changes associated with d-penicillamine were treated with 17alpha estradiol for three to six weeks. 17alpha estradiol caused no detectable changes in blood pressure, breast development, menstrua ...1976178033
electron microscopic features of lipoprotein-glycosaminoglycan complexes from human atherosclerotic plaques.lipoprotein-glycosaminoglycan (gag) complexes were isolated from fibrous plaque lesions of human aortas and examined by electron microscopy. after fractionation by gel chromatography and ultracentrifugation, both very low density lopoprotein-gag and low density lopoprotein-gag complexes showed particles which were mainly 1,000 to 2,000 a in diameter. occasional large aggregations 3,000 to 10,000 a in diameter were seen after gel filtration and in the very low density lipoprotein fraction of comp ...1976178962
brief communication effects of estradiol on feeding and locomotion in rem deprived rats. 1976179107
[molecular aspects of the formation of mitochondrial membranes]. 1976179238
fine structural analysis of rabbit synovial cells. ii. fine structure and rosette-forming cells of explant and monolayer cultures.the fine structure and plasma membrane receptors of explant and monolayer cells of normal rabbit synovium were studied. in explants about 10% of the cells were round and formed rosettes with igc and c3 markers, whereas the remaining cells were stellate, resembled young fibroblasts, and had no receptors for igg and complement. monolayer cells looked like fibroblasts, produced fine extracellular fibrils and hyaluronate, and formed no rosettes. thus early cultures contain both macrophages and fibro ...1976181009
type-c rna viruses and leukemogenesis: relation of type-c virus infectivity and leukemogenesis induced by nitrosourea compounds in mice.correlation between infectivity of type-c rna virus) murine leukemia virus, mlv) and development of leukemia was tested in female icr/jcl mice treated with either 1-ethyl-1-nitrosourea (enu) or 1-butyl-1-nitrosourea (bnu). continuous administration of either chemicals resulted in the occurrence of thymic lymphoma in every mouse with a short latent period. the time of appearance and distribution pattern of mlv infectivity in various tissues were examined by the xc plaque assay technique at fixed ...1976187521
dependence of macromolecular composition and morphology of streptomyces hygroscopicus on specific growth rate.the dependence of macromolecular composition and morphology of streptomyces hygroscopicus on specific growth rate micron was investigated. the percentage of dna on dry weight (%dna) is constant, % protein is also nearly independent of micron whereas %rna rises considerably with increasing micron, regarding mycelia grown in glucose-limited and ammonium-limited continuous cultures as well as in discontinuous cultures with various carbon sources. it is probable that the overall synthesis of dna, rn ...197994484
effect of dihydroergotoxine on cyclic-amp-generating systems in rat cerebral cortex slices of rat cerebral cortex, cyclic-amp formation is stimulated in response to added noradrenaline (na), isoproterenol (isp) or adenosine. the effect of isp could be antagonized only by the selective beta-adrenoceptor-blocking agent pindolol, whereas the stimulating effect of na could be antagonized by both alpha- and beta-adrenoceptor-blocking agents. dihydroergotoxine (dhet) at low concentrations (10(-8)m) antagonized the stimulating effect of na but not of isp or adenosine, suggesting th ...1978201544
fetal mouse lung in circumfusion system cultures.fetal mouse lungs were cultivated, using the dual-rotary circumfusion system for tissue culture, and their histotypic development was surveyed for 75 days by phase-contrast and electron microscopy. alveoli, terminal bronchioles and alveolar macrophages were photographed periodically with still and time-lapse phase-contrast microscopy. their histotypic appearance was confirmed by electron micrographs of the 1- and 2 1/2-month-old specimens. these revealed typical alveoli surrounded by a basal lam ...1977201560
prolonged infection of l cells with vesicular stomatitis virus. defective interfering forms and temperature-sensitive mutants as factors in the infection. 1978206006
[the effect of vitamin d3 on some parameters in the serum and bone of rats (author's transl)]. 1978206364
ca2+/protein modulator-dependent and -independent cyclic gmp phosphodiesterase from hog heart.ca2+/protein modulator-dependent and -independent guanosine 3':5'-monophosphate (cgmp) phosphodiesterases were separated from hog heart. the protein modulator-free ca2+/protein modulator-dependent enzyme was partially purified by repeated deae-cellulose column chromatography and heat treatment. the final preparation of this enzyme showed no significant basal activity under the standard assay conditions. lineweaver-burk plots of the ca2+/protein modulator-dependent enzyme activity indicated the p ...1978207685
histochemical, pharmacological and microspectrofluorometric analysis of new sites of serotonin localization in the rat hypothalamus.histopharmacological and microspectrofluorometric analysis was applied to the rat hypothalamus for the identification of serotonin. neuronal perikarya, especially certain of those of the endocrinologically important arcuate nucleus, were seen to contain a yellow histofluorescence which possessed spectral characteristics consistent with the serotonin fluorophor. serotonin was localized also within varicosities of various hypothalamic nuclei, as well as within an ependymally associated network of ...1978207746
characterization of the coronary vasodilator and hemodynamic actions of monensin, a carboxylic ionophore.the effects of monensin on coronary blood flow (cbf) and other hemodynamic parameters were studied in anesthetized dogs. a dose-response relationship was established, and it was found that the lowest doses of monensin (5-25 micrograms/kg) produced a dose-dependent increase (3-5x) in cbf with a concomitant decrease in total peripheral resistance (tpr). pretreatment with diphenhydramine, atropine, indomethacin, or propranolol resulted in no reduction in peak increase in cbf or in the duration of r ...197994374
[histological and histochemical studies of the gastric mucosa of the mouse under normal conditions and following various treatments]. 197994241
16, 16 dimethyl prostaglandin e2 reduces histamine release from the stomach and protects the gastric mucosal barrier altered by ethanol in neutral solution.damage to the gastric mucosal barrier results in histamine release from intramucosal stores. previous reports have shown that 16, 16 dimethyl prostaglandin e2 (dm pge2) protects the stomach from injury by various damaging agents in either acidic or neutral solution. furthermore histamine released in response to a damaging drug in an acidic medium was reduced by dm pge2. using the heidenhain pouch dog preparation, the present study examined the action of dm pge2 on ethanol-induced barrier breakin ...197993761
calcium-dependent increase in adenosine 3',5'-monophosphate and induction of the acrosome reaction in guinea pig spermatozoa.experiments were designed to determine the interrelationship between cyclic amp and ca(2+) during the processes of sperm capacitation and the acrosome reaction. in minimal culture media containing pyruvate and lactate as substrates, guinea pig spermatozoa required a minimum of 1.0-1.5 hr to capacitate in the presence of 1.7 mm ca(2+) and a minimum of 0.5-1.0 hr to capacitate in the absence of added ca(2+). sperm cyclic amp concentrations were increased by as much as 30-fold within 0.5 min after ...197993280
role of ca++ in virus-induced membrane fusion. ca++ accumulation and ultrastructural changes induced by sendai virus in chicken erythrocytes.some of the ultrastructural (freeze-etching technique), morphological, and biochemical effects of sendai virus interaction with chicken erythrocytes have been studied under fusogenic (in the presence of cacl2) and nonfusogenic (in the presence of ethyleneglycol-bis-n,n'-tetraacetic acid, [egta]) conditions. the following phenomena occur, irrespective of the presence of cacl2 or egta: (a) binding of iodinated virus particles to chicken erythrocytes at 4 degrees c and their partial release from th ...1978211140
detection of antigenically active mutant hgprt after mutagenesis with simian virus 40. 1978211410
[change in natural immunity under the effect of cysteine]. 1978211758
comparison of interferon action in interferon resistant and sensitive l1210 cells.translation inhibition, leu-trna aminoacylation and double-stranded rna and atp dependent phosphorylation were examined in interferon-treated and control cell-free lysates of leukaemic mouse l 1210 r and l 1210 s cells. no differences were observed between the respective interferon-treated and control cell-free extracts, except for the presence of an enhanced 67k dalton phosphoprotein fraction in interferon-treated l 1210 s cell-free extracts. in non-responding cell-free lysates, the lack of sti ...1978212514
the lipid-chemical features of the metastatic tissues into the liver from the human gastric cancer, large intestinal cancer and malignant order to clarify the biochemical features of metastatic tissues into the liver of human cancerous cells, 12 of primary cancerous tissues and 3 of metastatic tissues of the large intestinal cancer, 6 of primary cancerous tissues and 2 of metastatic tissues of the gastric cancer, and 3 of primary cancerous tissues and 3 of metastatic tissues of malignant insulinoma were studied lipid-chemically. cancerous tissues and metastatic tissues into the liver were collected by biopsy or surgical operati ...1978212845
[effect of sympathetic nerve stimulation on the microvascular permeability for proteins and lipoproteins]. 197992794
[technics of measuring the motive force of very small ameboid cells].a technic have been perfected which measures directly the motive force of very small ameboid cells and indicates the tropism of the amoeba. by using this technic, the motive force of entamoeba histolytica was measured. it varied between +/- 1.5 x 10-4 dyne. we have also shown chimiotactism in entamoeba histolytica. the metabolic coumpound excreted by this cell induced negative tropism.1978213820
[microinterferometric demonstration of sulfhydryl groups with 1-(4-chlormercuri-phenylazo)-beta-naphtol]. 197559491
[antihypoxic effect of analogs of cyclic adenosine monophosphate, phosphodiesterase inhibitors].a number of investigated camp derivatives are shown to inhibit the camp-phosphodiesterase in brain tissues of white rats in vitro. the 8-substituted aminoethylamino-derivatives proved to be effective inhibitors of the enzyme. among them the most pronounced inhibition displayed the 8-(beta-aminoethylamino)-camp. in an in vitro experiment on the model of hypoxic hypoxia in rats it was shown to possess strong anti-hypoxic properties. the possible prospective clinical use of the camp analogs--inhibi ...1978214339
streptococcal m protein extracted by nonionic detergent. i. properties of the antiphagocytic and type-specific a streptococcal m protein was extracted with nonionic detergent and subjected to a number of physical, chemical, and immunological tests. m protein thus extracted was composed of multiple protein bands, ranging from 35,000 down to 6,000 daltons, all having type-specific precipitating activity. the anti-phagocytic proteins, however, were limited to three molecular species having mol wt of 28,000, 31,000, and 35,000 daltons, and could be separated from those proteins that had only type speci ...197658958
oxygen metabolism by the anaerobic bacterium veillonella alcalescens. 197831846
re-evaluation of the role of cyclic amp in histamine-induced gastric acid secretion.the 600 x g particulate fraction of gastric mucosal scrapings from rats was incubated with 3h-metiamide which saturated available binding sites at a concentration of 1 mum. scatchard plots showed a single component with a kd value of 0.2 mum. unlabelled cimetidine and histamine competed with 3h-metiamide binding. the 600 x g particulate fraction also contained all of the hormone and sodium fluoride sensitive adenylyl cyclase. adenylyl cyclase activity was not altered by histamine, pentagastrin o ...1976177326
hormone-induced diarrhea in a healthy subject infusions of either secretion or glucagon caused no diarrhea. a combinations of gastrin and glucagon induced severe watery diarrhea immediately after the end of the 3 hour infusion. no diarrhea occurred from the combination of secretin and gastrin.1975176861
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