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antimicrobial susceptibility of vibrio cholerae from zaire and rwanda. 197990940
cell-free synthesis and segregation of beta 2-microglobulin.beta2-microglobulin has been synthesized in vitro by using a rabbit reticulocyte lysate system and mrna from the mouse tumor cell line el4. the molecule is synthesized as a precursor with an nh2-terminal extension of 19 amino acids: ser-x-ser-val-x-leu-val-phe-leu-val-leu-val-ser-leu-x-gly-leu-tyr-x. the processing and segregation of this peripheral membrane protein are directly comparable to those of secretory proteins and integral membrane proteins: addition of dog pancreas microsomal membrane ...197991168
the zinc-iodide-osmium technique in studies of the neurosecretory system in rats. 197991310
[orthosympathetic stimulation after hypercapnia in the rat].inhalation of a gas mixture : co2, 25% -- o2, 37.5% -- n2, 37.5%, provokes regularly in the light anaesthetized rat, an increase of catecholaminemia of central origin, associated with systemic arterial hypertension.197992225
the accessibility of antigenic determinants of ribosomal protein s4 in situ.antibodies to escherichia coli ribosomal protein s4 react with s4 in subribosomal particles, eg, the complex of 16s rna with s4, s7, s8, s15, s16, s17, and s19 and the ri reconstitution intermediate, but they do not react with intact 30s subunits. antibodies were isolated by three different methods from antisera obtained during the immunization of eight rabbits. some of these antibody preparations, which contained contaminant antibodies directed against other ribosomal proteins, reacted with sub ...197992615
aberrant form of hymenolepis nana: possible opportunistic infection in immunosuppressed patients. 197992715
the carbohydrate content of apolipoprotein e from human very low density lipoproteins. 197992742
reverse transcriptase-associated rnase h. part iv. pyrophosphate does not inhibit rnase h activity of amv dna polymerase. 197993479
[purification and characterization of the free secretory piece of human colostrum (author's transl)].the free secretory piece is isolated from human colostrum by gel filtration and ion-exchange chromatography in high yield (200 mg/l colostrum). deae-cellulose chromatography separates the free secretory piece in two fractions which are electrophoretically distinct, but otherwise have the same characteristics, like molecular weight, antigenic determinants, n-terminal sequence, peptide map and amino acid composition. it was therefore concluded that the protein part of the secretory piece is homoge ...197993565
chlorpyrifos and 3,5,6,-trichloro-2-pyridinol: residues in the body tissues of cattle wearing chlorpyrifos-impregnated plastic ear tags. 197993609
preferential replication of murine xenotropic type-c virus in human lymphosarcoma-derived cell lines.murine xenotropic virus, designated 698/x, was recovered by implantation of human lymphosarcoma-derived cells u-698m into nude mice of giovanella's colony. the budded and extracellular particles revealed typical type-c morphology, the latter possessing reverse transcriptase (rt) activity and exhibiting a buoyant density 1.17 g/ml in sucrose gradient. in competitive radioimmunoassay using iodinated p30 of rauscher mulv, the 698x viral concentrate and cell extracts of both implanted lymphosarcoma ...197993707
characterization of the coronary vasodilator and hemodynamic actions of monensin, a carboxylic ionophore.the effects of monensin on coronary blood flow (cbf) and other hemodynamic parameters were studied in anesthetized dogs. a dose-response relationship was established, and it was found that the lowest doses of monensin (5-25 micrograms/kg) produced a dose-dependent increase (3-5x) in cbf with a concomitant decrease in total peripheral resistance (tpr). pretreatment with diphenhydramine, atropine, indomethacin, or propranolol resulted in no reduction in peak increase in cbf or in the duration of r ...197994374
neovasculogenesis. triggering factors and possible mechanisms.the possible regulating mechanism(s) of neovascularization are discussed. experimental data supporting the view that ocular neovascularization might be triggered by a fundamental metabolic mechanism are presented. based on his own data and scattered evidence from the literature, the author suggests a model for a possible regulating mechanism of the neovascular process in which the prostaglandins fulfill the role of neovascular mediating substances. preliminary results demonstrating that indometh ...197994468
factors involved in the age-dependent resistance of mice infected with low-virulence mouse hepatitis virus.four-week-old weanling mice survived, whereas 1-week-old suckling mice died, after intraperitoneal inoculation of mouse hepatitis virus, mhv-s strain. the factors involved in this difference in susceptibility were studied. after virus inoculation, differences in virus growth in the liver and spleen were observed, which correlated with the susceptibility of animals to the virus. interferon, detected at an early stage of infection, was considerably lower in suckling mice than in weanling mice. tit ...197994538
pyrazolidine derivatives: a comparative study of their effects on platelet aggregation.quantitative studies were carried out of the in vitro and ex vivo effects of phenylbutazone and 3-oxoalkyl substituted diphenyldioxopyrazolidines (kebuzone, tribuzone, benzopyrazone) on platelet aggregation. the specified pyrazolidine derivatives exhibited in vitro inhibitory effects on secondary platelet aggregation (induced by adrenaline and collagen), commensurable with the effects of sulfinpyrazone. the ex vivo efficacy was markedly influenced by the height of the drug level in blood and by ...197994876
staining with chromoxane cyanine r.since pearse in 1957 introduced chromoxane cyanine r as a dual nuclear and cytoplasmic stain there have appeared numerous procedures for use of this dye. these have differed widely, sharing in common mainly the implication that each is best. a defendable procedure has been developed on an experimental basis and is reported here. four stock solutions are needed: (1) a 0.2% solution of chromoxane cyanine r in 0.5% aqueous h2so4 (v/v); boil this solution for 5 min, (2) 10% fecl3 in 3% hcl, (3) 1% a ...197994954
the effect of cyclophosphamide on a secondary ocular immune response in rabbits.treatment of rabbits with immunosuppressive doses of cyclophosphamide during the primary response to intravitreally injected bovine gamma globulin did not prevent priming for a secondary response to the same antigen. high antibody titers were found in the aqueous humor and serum of most of the treated rabbits. ocular tissue plaque forming cell numbers were similar to those of the controls in many of the rabbits, and slightly lower in others. treatment with cyclophosphamide completely suppressed ...197994972
[hepatitis b virus during pregnancy and its consequences in perinatology]. 197995065
visualization of mitochondrial coupling factor f1(atpase) by freeze-drying.it is known that the negatively stained preparations of inner mitochondrial membrane display characteristic approximately 9 nm f1 (atpase) knobs projecting from the matrix surface. freeze-etch studies have reported the absence of such knobs from the "etched" surface of the inner mitochondrial membranes. we have demonstrated their presence on the surface of smp (submitochondrial particles) prepared by freeze-drying for transmission electron microscopy. this identification has been substantiated b ...197995168
world veterinary manpower: comparative aspects.the number of veterinarians in relation to livestock units, human population, milk and meat production and gross national product for 93 countries is presented. the structure of veterinary manpower is discussed and information on veterinary involvement with companion animals and public health is given. for 23 countries representing all the continents, the number of livestock units, human population and gross national product per veterinary school are presented.197995360
dextran anaphylactoid reaction in sprague-dawley cfy rats.from a closed colony of randomly-bred sprague-dawley cfy rats about 23% failed to respond to intravenous dextran with the characteristic generalized anaphylactoid reaction, but still exhibited an inflammatory response when dextran was given into the foot pad. brother-sister mating of rats showing the most expressed generalized reaction (reactor rats) yielded good responder offsprings, while the non-reactors had descendants completely unresponsive to systemic dextran. brother-sister mating of sel ...197995467
16, 16 dimethyl prostaglandin e2 reduces histamine release from the stomach and protects the gastric mucosal barrier altered by ethanol in neutral solution.damage to the gastric mucosal barrier results in histamine release from intramucosal stores. previous reports have shown that 16, 16 dimethyl prostaglandin e2 (dm pge2) protects the stomach from injury by various damaging agents in either acidic or neutral solution. furthermore histamine released in response to a damaging drug in an acidic medium was reduced by dm pge2. using the heidenhain pouch dog preparation, the present study examined the action of dm pge2 on ethanol-induced barrier breakin ...197993761
photobehavior of microorganisms: a biophysical approach. 197896724
studies on the occurrence of peptococcus indolicus and corynebacterium pyogenes in abscesses in swine, and on the occurrence of pc. indolicus in apparently normal skin and mucous membranes of piglets.pc. indolicus was isolated from 42.7% and cb. pyogenes from 48.7% of 150 pus-samples from abscesses in pigs (slaughter-house material, table i). in 41 specimens the two organisms were found together. further, pc. indolicus was demonstrated in 22.4% of 290 swabs from apparently normal skin and mucous membranes of piglets (autopsy material, table ii). by gel diffusion analysis the strains of pc. indolicus were referred to the serotypes b, c, d, e, or f. the type distribution (table iii) possibly r ...197898755
production and chemical studies of protease from bacillus subtilis (sh-6) egyptian strain.bacillus subtilis (sh-6) egyptian strain, isolated from hides, gave the highest protease activity. luxurious growth and protease production were obtained by the use of a medium containing 8% of potato starch, 0,1 m of ammonium phosphate as carbon and nitrogen sources. results indicate that borate buffer exerted a deleterious effect on the protease production. comparing citrate and phosphate buffers, it was found that citrate gave lower protease activity than phosphate. there is a positive respon ...197898932
biological variation of immunoglobulin concentrations in normal human tears related to age and sex.single radial immunodiffusion method was used to measure the concentration of igg, iga, igm and igd in tears of 220 healthy individuals aged from 2 to 86 years. relation of the values to age and sex has been evaluated statistically by regression analysis method. mean iga level was 30.7 mg/100 ml. igg could be detected in 200 samples and the level was less than 1 mg/100 ml. igm was detected in only 7 samples and the value was less than 1 mg/100 ml. igd could not be detected in any of the sample. ...197898956
[transplantation of langerhans' islands]. 197899549
ineffectiveness of prophylactic intrathecal methylprednisolone in myelography with aqueous media.the effectiveness of prophylactic intrathecal methylprednisone (mp) in preventing arachnoiditis from iocarmate myelography was studied. monkeys were injected intrathecally with locarmate, mp, or a combination of the two. twelve weeks later the severity of arachnoiditis was determined in each animal. there was no significant prophylactic effect of intrathecal mp on arachnoiditis from locarmate. some arachnoiditis was found in control animals treated with mp alone.197899764
substance p as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation. 197993706
the fine specificity of regulatory t cells. iv. idiotypic complementarity and antigen-bridging interactions in the anti-lysozyme response.the hen egg-white lysozyme (hel)-specific b cells which are activated in response to hel share a cross-reactive idiotype as well as submolecular specificity. helper t cells of two different specificities are implicated in their optimal activation, one recognizing the idiotype and the other, an epitope on the hel molecule opposite to the one recognized by b cells. thus, efficient t-b collaboration involves both idiotypic complementary and antigen bridging.197993548
transfer of polychlorinated biphenyls from mothers to foetuses and infants. 1978103790
production of anti-antipyrine antibody by immunization with 4-azoantipyrine-conjugated bovine serum albumin. 1978103791
[isolation of treponemas from the colon of pigs with clinical dysentery].optimal culture conditions in artificial nutritive media were determined for a defined avirulent strain of treponema hyodysenteriae and for four field strains of treponemas in pigs with clinical dysentery. the treponemas were isolated with the use of milliporous filters with pores of 0.3 micrometer in diameter, which were located on the surface of blood agar. no significant difference in the influence of equine, bovine or sheep blood on the growth of treponemas was determined. the commercial amo ...1979105448
evidence for reappearance of trypanosoma brucei variable antigen types in relapse populations.seven out of 11 bovines infected with different clones of trypanosoma brucei showed 2 peaks of antibody activity against the infecting clone within 7 weeks, as measured by immunofluorescence, radioimmunoassay, and neutralization of infectivity tests. using other clones from an unrelated stock, antibodies to these clones were not detectable, indicating that the antibodies produced were specific to the infecting organisms. these results suggest that there was a reappearance or increase in numbers ...197992560
the murine kupffer cell. i. characterization of the cell serving accessory function in antigen-specific t cell proliferation.murine kupffer cells, the tissue macrophages of the liver, were isolated by collagenase digestion, differential sedimentation over metrizamide, and glass adherence. the resultant cell population was more than 86% phagocytic, and 95% of cells stained positively for alpha-naphthyl butyrate esterase activity. the cells also had cell surface receptors for complement (c) and the fc portion of igg. in addition, a large proportion of kupffer cells was shown to bear ia antigens: about half of the cells ...197991637
streptococcal m protein extracted by nonionic detergent. i. properties of the antiphagocytic and type-specific molecules.group a streptococcal m protein was extracted with nonionic detergent and subjected to a number of physical, chemical, and immunological tests. m protein thus extracted was composed of multiple protein bands, ranging from 35,000 down to 6,000 daltons, all having type-specific precipitating activity. the anti-phagocytic proteins, however, were limited to three molecular species having mol wt of 28,000, 31,000, and 35,000 daltons, and could be separated from those proteins that had only type speci ...197658958
primary meningococcal conjunctivitis in an infant.a case of primary meningococcal conjunctivitis in an infant was presented and its treatment is discussed. because of the potential for systemic spread of the infection in the patient, local and systemic therapy was instituted. the current literature on meningococcal conjunctivitis with its potential complications is briefly reviewed.1979106998
the subicular cortex of the cat: an anatomical and electrophysiological study. 1979107038
glycogen synthase kinase-2 from rabbit skeletal muscle is activated by the calcium-dependent regulator protein. 1979107045
antibodies against measles antigen in the laboratory housed rhesus and bonnet monkeys. 1979107117
localization of neurons supplying the temporalis muscle in the rat and monkey.following injection of horseradish peroxidase (hrp) solution into the rat and monkey temporalis muscle, a similar pattern of nuclear representation was found in the motor trigeminal nucleus. labelled neurons were seen throughout the rostro-caudal extent of the ipsilateral motor trigeminal nucleus, in its dorsal, intermediate and ventral portions and its dorsomedial, ventromedial and ventrolateral corners. in addition to the motor trigeminal nucleus labelled neurons were also found in the ipsilat ...1979107492
studies on allergenic algae of delhi area: botanical aspects.to study distribution of algae in and around delhi aerobiological surveys were undertaken for two consecutive years (september, 1972, to august, 1974). the surveys were accomplished by (a) slide exposure method and (b) culture plate exposure method. a total of 850 slides were exposed using durham's gravity sampling device. of these, 560 slides were exposed during 1973 (272 slides at two meter and 288 at ten meter height) and the rest (290 slides) were exposed during 1974 at ten meter height. a t ...1979107835
on the pharmacology of venous smooth muscle from dog and man.changes in tension of spiral strips from canine and human veins induced by various drugs are compared with results from the literature on human veins. the order of potencies of alpha-adrenoceptor stimulating amines (adrenaline greater than noradrenaline greater than dopamine greater than isoprenaline) is similar in human and canine veins. comparison of the affinities for alpha-adrenoceptors of pharmacologic drugs (thymoxamine, indoramine, clonidine, dihydroergotamine) suggest marked differences ...197994863
[characteristics of human dental pulp cells in cell cultures].the generation time and the division rate were measured with routine methods of cell culturing. the conditions contributing to the stagnation of growth were examined; the synchrony of the growth process was investigated. the biochemical composition of the cells was assessed via colorimetry and then compared with other cell systems. the cell culture examined may be used to test capping materials; only cells up through the eighth generation however should be utilized.197994854
the effects of metiamide and h1 receptor blocking agents on anaphylactic response in guinea-pigs.the effects of metiamide and of four h1 receptor blocking agents (mepyramine, promethazine, clemastine and ketotifene) on anaphylactic reaction were studied in the guinea-pig. the h1 blockers conferred partial protection which shows that with the experimental protocol utilized (challenge injection with high doses of antigen), histamine plays a lesser role than other mediators released or synthesized. metiamide (30.0 mg/kg i.v.) noticeably enhanced the increase in pulmonary resistance observed du ...197994763
correlation between hepatic transport of cholephilic organic anions and their effect on hepatic mitochondrial respiration.the maximum biliary excretion rate (tm) of some nonmetabolized organic anions was investigated in anaesthetized male rats and was found to increase in the following order: indocyanine green (icg), rose bengal (rb), bromsulphthalein (bsp; its conjugation with glutathione was prevented by diethyl maleate), bromcresol green (bcg), eosine (e), bsp-glutathione conjugate (bsp-gsh), iodoxamic acid (ia) and amaranth (a). the accumulation of icg, rb, bsp and bcg in liver was relatively high, whereas e, b ...197994737
the role of antigen-specific t cell factors in the immune response. 197994504
dependence of macromolecular composition and morphology of streptomyces hygroscopicus on specific growth rate.the dependence of macromolecular composition and morphology of streptomyces hygroscopicus on specific growth rate micron was investigated. the percentage of dna on dry weight (%dna) is constant, % protein is also nearly independent of micron whereas %rna rises considerably with increasing micron, regarding mycelia grown in glucose-limited and ammonium-limited continuous cultures as well as in discontinuous cultures with various carbon sources. it is probable that the overall synthesis of dna, rn ...197994484
[prognostic value of alpha-foetoprotein in fulminant hepatitis (author's transl)].serum concentrations of alpha-foetoprotein (afp) were measured sequentially by radioimmunoassay in 32 patients with fulminant hepatitis and coma, 22 of whom died. levels were significantly elevated in 100% of patients who survived and in 7 out of 22 patients (38.5%) who died (p = less than 0.005). in the survivors the rise of afp levels was found early after the development of coma and subsequently in all serum samples obtained during acute phase of illness. in 2 of 7 fatal cases who had raised ...197994446
influence of atropine on spontaneous or catecholamine-induced arrhythmias after experimental infarction in the dog.the effects of atropine on ventricular tachyarrhythmias induced by ligature of the anterior descending coronary artery were studied in conscious dogs. on the first day after surgery, animals received a mixture of quinidine and phenytoin orally in order to partially correct rhythm disturbances on the second day. the same animals were used on the third and fourth days after occlusion, when spontaneous regression of arrhythmias was occurring. atropine (0.2 mg/kg i.v.) or methscopolamine (0.2 mg/kg ...197994403
hyperactivity induced by tetrahydroisoquinoline derivatives injected into the nucleus accumbens.several derivatives of tetrahydroisoquinoline were injected bilaterally into the nucleus accumbens of rat 2 h after a nialamide pretreatment and activity recorded in cages fitted with photocells. 1,2,3,4-tetrahydroisoquinoline, 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline, 1,2,3,4-tetrahydro-6,7-dihydroxy-1-(3,4-dihydroxybenzyl)-isoquinoline (tetrahydropapaveroline) and 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline caused virtually no change in locomotor activity and 2-methyl-1,2,3,4-tetrahydrois ...1976134899
[super-selective cerebral angiography. iii. diagnostic use and therapeutic possibilities of the telescopic catheterization technic in the circulation area of the external carotid artery in man].the diagnostic value and technical versatility of the previously described telescopic catheter system was demonstrated in 15 patients by super-selective angiography of the external carotid artery. it was possible in all patients to catheterise the individual branches with the f-catheter; the polyethylene-s-catheter could then be passed 3 to 5 cm, beyond the tip of the f-catheter. in almost half the patients, spasm of the injected artery was observed, particularly of the superficial temporal and ...1976134945
[histological and histochemical studies of the gastric mucosa of the mouse under normal conditions and following various treatments]. 197994241
[effect of sympathetic nerve stimulation on the microvascular permeability for proteins and lipoproteins]. 197992794
fluorescence of human liver alanine aminopeptidase.fluorescence of human liver alanine aminopeptidase has been attributed to tryptophan fluorescence. the fluorescence maximum is at 330 nm, 20 nm lower than that for free tryptophan, suggesting that most of the enzyme tryptophans are in a nonpolar environment and are shielded from solvent. quenching of enzyme fluorescence by iodide, pyridine, and n-methyl nicotinamide also demonstrates that enzyme tryptophan residues are largely buried and inaccessible to solvent. those accessible are in negativel ...1977143669
[skin disease in cattle, caused by dermatophilus congolensis]. 197553909
[acid-base equilibrium in mother and fetus during labor and the resistance of newborn calves].investigated were a total of 59 cows presenting normal processes, of giving birth as well as dystocia, the time of delivery lasting 2, 10, 24, and 36 hours. seventeen cows with dystocia were treated intravenously with 500 cm3 of a 4 per cent solution of sodium bicarbonate and 40 g glucose. it was found that the changes in the ph values, alkali reserves, glycogen, and the peroxydase activity of the neutrophiles in the mothers and fetuses were dependent on the duration of parturition. cases of dif ...197834922
cellular factors. immunologic tolerance: irradiation and bone marrow transplantation in induction of canine allogeneic unresponsiveness. 197717203
[microinterferometric demonstration of sulfhydryl groups with 1-(4-chlormercuri-phenylazo)-beta-naphtol]. 197559491
oxygen metabolism by the anaerobic bacterium veillonella alcalescens. 197831846
persistent or slow viral infections and related diseases.the discovery of persistent transmissible agents by veterinarians has led to striking advances in the infectious cause of neuropathies of human beings. there is evidence for persisting infection in congenital rubella and the herpes group of viruses including cytomegalovirus infections. hepatitis types a and b are candidates for inclusion in the category of persisting viral infections. the rubeola or measles virus is established as a persistent virus which causes elevated antibodies in the serum ...1975165638
has myelin basic protein received a fair trial in the treatment of multiple sclerosis?autosensitization to some central nervous system antigen still remains one of the best hypotheses for the continuing pathogenesis of multiple sclerosis (ms). enough is now known about the cause, pathogenesis, and treatment of experimental allergic encephalomyelitis (eae) to test this hypothesis. reports of therapeutic failure of the encephalitogen myelin basic protein (bp) in the treatment of ms have their counterparts in similar therapeutic failures in eae. only highly inbred strain 13 guinea p ...197993873
nitric oxide complexes of cytochrome p-450. 1975166885
structure of a 30 s pre-ribosomal rna of e. coli. 1975169158
[ultrastructural aspects of keratinization of the rat oral mucosa. iii. gums (author's transl)]. 197995578
hormone-induced diarrhea in man.in a healthy subject infusions of either secretion or glucagon caused no diarrhea. a combinations of gastrin and glucagon induced severe watery diarrhea immediately after the end of the 3 hour infusion. no diarrhea occurred from the combination of secretin and gastrin.1975176861
rubrospinal effects on ventral spinocerebellar tract neurones.stimulation of the contralateral red nucleus evoked monosynaptic epsps in 14 of 82 ventral spinocerebellar tract neurones. in some of these cells the monosynaptic epsp was followed by a disynaptic ipsp. the remaining cell population received di- or polysynaptic psps from the rubrospinal tract, either epsps or ipsps or both. convergence of the rubrospinal tract onto interneurones of the segmental pathways projecting to vsct cells was demonstrated. rubrospinal volleys facilitated disynaptic ia ips ...1976176875
gastrin-related compounds and their effect on gastric-acid and gastrin output in the dog. 1975123975
human carotid artery diameter and flow by a noninvasive technique.this paper presents a technique tested in vitro and in dogs and used in humans to measure carotid artery blood flow continuously by placing a transducer on the skin over the artery. the tranducer consists of a pulse echo crystal used to locate the carotid artery and measure its diameter and wall velocity. it also has a pair of doppler shift crystals used to measure the velocity of the artery wall and blood flow in the vessel. it was found that the pulsatile artery wall distension was between 8 a ...1975124007
endotoxin-like properties of the peptidoglycan.peptidoglycan is responsible for the endotoxin-like properties of the streptococcus cell wall. the pyrogenic response of rabbit to group a streptococcus peptidoglycan prepared by hot formamide or tca is dose-dependent and is increased if the material is ultrasonically solubilized. the pyrogenicity can be eliminated by the antiserum to the peptidoglycan or by the degradation of the material by lysozyme. peptidoglycans prepared from cell walls of group b and l streptococci, staphylococcus aureus, ...1975126556
glycosaminoglycans and acidic glycoproteins in rabbit uterus under estrogenic conditions.uterine slices obtained from the estrogen-treated rabbits were digested with pronase. glycosaminoglycans and acidic glycopeptides were then isolated by dowex 1 column chromatography and preparative electrophoresis on cellulose acetate membrane (separax), in succession. each subfraction thus obtained was identified by the mobility on separax electrophoresis and the digestibility with mucopolysaccharidases (streptomyces hyaluronidase, testicular hyaluronidase, chondroitinase ac, chondroitinase abc ...1975126700
electron microscopic features of lipoprotein-glycosaminoglycan complexes from human atherosclerotic plaques.lipoprotein-glycosaminoglycan (gag) complexes were isolated from fibrous plaque lesions of human aortas and examined by electron microscopy. after fractionation by gel chromatography and ultracentrifugation, both very low density lopoprotein-gag and low density lopoprotein-gag complexes showed particles which were mainly 1,000 to 2,000 a in diameter. occasional large aggregations 3,000 to 10,000 a in diameter were seen after gel filtration and in the very low density lipoprotein fraction of comp ...1976178962
[effect of some antidiuretic agents on the polyuria-polydipsia provoked by alcohol].the authors have studied in the dog--normal or diabetic insipidus after hypothalamic lesion--submitted to oral ingestion of ethanol the effects of a few antidiuretic drug: chlorpropamid, atromid-s, carbamazepin and carisoprodol. the carisoprodol only can reduce the diuresis and the drinking provoked by ethanol.1975126784
[molecular aspects of the formation of mitochondrial membranes]. 1976179238
fine structural analysis of rabbit synovial cells. ii. fine structure and rosette-forming cells of explant and monolayer cultures.the fine structure and plasma membrane receptors of explant and monolayer cells of normal rabbit synovium were studied. in explants about 10% of the cells were round and formed rosettes with igc and c3 markers, whereas the remaining cells were stellate, resembled young fibroblasts, and had no receptors for igg and complement. monolayer cells looked like fibroblasts, produced fine extracellular fibrils and hyaluronate, and formed no rosettes. thus early cultures contain both macrophages and fibro ...1976181009
type-c rna viruses and leukemogenesis: relation of type-c virus infectivity and leukemogenesis induced by nitrosourea compounds in mice.correlation between infectivity of type-c rna virus) murine leukemia virus, mlv) and development of leukemia was tested in female icr/jcl mice treated with either 1-ethyl-1-nitrosourea (enu) or 1-butyl-1-nitrosourea (bnu). continuous administration of either chemicals resulted in the occurrence of thymic lymphoma in every mouse with a short latent period. the time of appearance and distribution pattern of mlv infectivity in various tissues were examined by the xc plaque assay technique at fixed ...1976187521
[effect of bay 2222 in the "pour-on" method on dictyocaulus and trichostronglides in cattle]. 1975127580
[study of the incorporation of radioactive zinc in saccharomyces cerevisiae aldolase].saccharomyces cerevisiae aldolase concentrates from the culture medium containing znso4 a large amount of zn which becomes a component part of the enzyme molecular structure. this was made evident by adding to the culture medium 65znso4 and measuring the radioactivity of the aldolase extracted by a phillips single channel analyzer.1976133445
the role of the pituitary in acne. 1976138539
suppressor cells in the spleen of tumor-allosensitized mice.c57bl/6 mice were sensitized i.p. with 20 x 10(6) p-815 mastocytoma cells. spleen and lymph node cells from these tumor-allosensitized mice become hyporesponsive in mixed-lymphocyte culture. the hyporesponsiveness appears to be due to the presence of suppressor cells. these suppressor cells can be demonstrated by their ability to inhibit the mixed-lymphocyte culture reactivity of normal mouse spleen cells. suppressor activity in the spleen of tumor-allosensitized mice remains long after cytotoxi ...1977141979
[isoenzymes in neoplasms]. 1976176637
the isolation and partial characterization of the serum lipoproteins and apolipoproteins of the rainbow trout.1. vld (very-low-density), ld (low-density) and hd (high-density) lipoproteins were isolated from the serum of trout (salmo gairdneri richardson). 2. each lipoprotein class resembled that of the human in immunological reactivity, electrophoretic behaviour and appearance in the electron microscope. trout ld lipoprotein, however, was of greater density than human ld lipoprotein. 3. the trout lipoproteins have lipid compositions which are similar to those of the corresponding human components, exce ...1978100102
histochemical, pharmacological and microspectrofluorometric analysis of new sites of serotonin localization in the rat hypothalamus.histopharmacological and microspectrofluorometric analysis was applied to the rat hypothalamus for the identification of serotonin. neuronal perikarya, especially certain of those of the endocrinologically important arcuate nucleus, were seen to contain a yellow histofluorescence which possessed spectral characteristics consistent with the serotonin fluorophor. serotonin was localized also within varicosities of various hypothalamic nuclei, as well as within an ependymally associated network of ...1978207746
restricted posterior parietal lesions in the rhesus monkey and performance on visuospatial tasks.monkeys with lesions restricted to the inferior parietal lobule or the banks and depths of the superior temporal sulcus were tested on a route-following task. these areas are considered on neuroanatomical grounds to be homologous to parts of the human posterior parietal cortex, where lesions produce profound spatial disorientation. the operated monkeys were impaired on the route task, thus confirming at the behavioural level the anatomical predictions of comparability between parietal cortex in ...1979103604
nerve conduction velocity of small components in human sensory nerves. studies in normal and diseased nerves.slow conducted components of sensory nerve action potentials were investigated in median and in sural nerves of controls and in patients with peripheral nerve diseases. in the normal group the slow components showed no relation to age which is in contrast to the maximum velocity. in both the median nerve and sural nerve of about 20% of the patients with neuropathy exclusively a decrease of the conduction velocity of slow components was found, the other investigated parameters were normal. possib ...1977210021
vestibulo-ocular reflex from the posterior canal nerve to extraocular motoneurons in the cat.in the anesthetized cat, the posterior canal nerve (pcn) was stimulated by electric pulses and synaptic responses were recorded intracellularly in the three antagonistic pairs of extraocular motoneurons. pure reciprocal effects were obtained in the motoneurons innervating the antagonistic pair of ipsilateral oblique muscles and the antagonistic pair of contralateral vertical rectus muscles. these responses consisted of low threshold disynaptic excitatory postsynaptic potentials (epsps) in either ...1978210032
vestibular effects of electrical stimulation of the cochlea. monitored in the awake primate.the effect of electrical stimulation of the cochlea on vestibular response was monitored in six rhesus monkeys. eye movements and single-unit activity from the vestibular portion of the eighth nerve, vestibular nuclei, reticular formation, and abducens nucleus were observed while electrical stimulation was delivered through an implanted cochlear prosthesis. in one animal of this series, neural activity from the inferior colliculus and cochlear nuclear complex was also recorded. electrical stimul ...1979106814
calcium-dependent increase in adenosine 3',5'-monophosphate and induction of the acrosome reaction in guinea pig spermatozoa.experiments were designed to determine the interrelationship between cyclic amp and ca(2+) during the processes of sperm capacitation and the acrosome reaction. in minimal culture media containing pyruvate and lactate as substrates, guinea pig spermatozoa required a minimum of 1.0-1.5 hr to capacitate in the presence of 1.7 mm ca(2+) and a minimum of 0.5-1.0 hr to capacitate in the absence of added ca(2+). sperm cyclic amp concentrations were increased by as much as 30-fold within 0.5 min after ...197993280
detection of antigenically active mutant hgprt after mutagenesis with simian virus 40. 1978211410
[change in natural immunity under the effect of cysteine]. 1978211758
comparison of interferon action in interferon resistant and sensitive l1210 cells.translation inhibition, leu-trna aminoacylation and double-stranded rna and atp dependent phosphorylation were examined in interferon-treated and control cell-free lysates of leukaemic mouse l 1210 r and l 1210 s cells. no differences were observed between the respective interferon-treated and control cell-free extracts, except for the presence of an enhanced 67k dalton phosphoprotein fraction in interferon-treated l 1210 s cell-free extracts. in non-responding cell-free lysates, the lack of sti ...1978212514
delayed hypersensitivity to chlamydia trachomatis: cause of chronic prostatitis. 197993221
primary afferent depolarisation of tooth pulp afferents is not affected by naloxone. 1978213729
effect of cortisone on aspartate and alanine aminotransferases in a desert lizard.1. liver and serum aspartate aminotransferase (got) and alanine aminotransferase (gpt) activities were measured in a hibernating desert lizard, uromastix hardwickii. the levels of both enzymes were found to be lower in hibernation than during the active period, particularly in the liver. 2. after intramuscular injection of 2 mg of cortisone acetate there was a rapid rise in the levels of these enzymes with a peak of 18 hours (got) and 12 hours (gpt). 3. the response of both enzymes to cortisone ...1978149452
interaction of phenosafranine with nucleic acids and model polyphosphates. iii. heterogeneity in phenosafranine interactions with dna base pairs.fluorescence and circular dichroism spectral measurements, thermal denaturation studies and binding competition experiments with netropsin and actinomycin d were carried out in systems containing phenosafranine bound to dna's differing in base composition. the investigated properties exhibit a heterogeneity related to the content of a.t and g.c pairs in dna and to the nature of phenosafranine binding modes. at low level of saturation of binding sites (r less than 0.1) phenosafranine does not sho ...1979106900
[role of the raphe magnus nucleus in morphine analgesia : studies with intracerebral microinjections in the rat].microinjections of low concentration of morphine (5 micrograms) into the nucleus raphé magnus of the rat produce a strong analgesia that can be reversed by systemic naloxone, an opiate antagonist. the administration of naloxone (5 micrograms) into the raphé magnus considerably reduces the effects of intravenous morphine. the effects of microinjections of morphine are strongly reduced by cinanserin, suggesting a role for serotoninergic mechanisms in morphine analgesia.1978106979
a catheter flow probe for measurement of left ventricular source parameters. 1979161547
effects of ryanodine on model systems derived from muscle-v. reconstituted actomyosin and alpha-actinin. 1975122894
a study of endotoxemia in ulcerative colitis and crohn's disease. i. clinical study.endotoxin (lipopolysaccharide, lps) and lps antibody in the blood were studied in 61 cases of ulcerative colitis (u.c.) by radioimmunoassay. lysozyme (lzm) concentration was also studied by the turbidimetric method. as a result, it was found that the blood lps value as well as serum lzm concentration reflects the clinical observations. the case of endotoxemia in the active phase group showed a positive correlation between the lps value and lzm concentration. lps antibody which could not be detec ...1978150200
potentiation of coxsackievirus b3 infection in adult mice pretreated with a gold salt.in mice treated with sodium aurothiomalate (myocrisin), prior to infection with coxsackievirus b3, 90% of the animals died by the 11th day postinfection (p.i.). a mortality of 10% was noted in mice receiving myocrisin only, and no deaths occurred in animals infected with virus alone. the highest amount of virus was recovered from the pancreas of myocrisin-treated mice on day 3 p.i. this was over 500-fold higher than the virus titer found in the pancreas of mice infected with virus only. generall ...1978215719
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