| acupuncture: its neurophysiological basis: an anaesthetist's foreword. | | 1978 | 29773 |
| vibrio ("beneckea") vulnificus, the bacterium associated with sepsis, septicaemia, and the sea. | | 1979 | 90993 |
| selective vital staining of companion cells of potato tuber and parsnip root with neutral red. | when staining the internal phloem region of a potato tuber with the vital stain neutral red, it was observed that files of elongated cells of narrow diameter were heavily stained and were easily distinguishable from the more isodiametric parenchyma cells, many of which did not stain with neutral red. the elongated cells were identified as companion cells by locating the adjacent sieve-tube members through counterstaining with aniline blue and reviewing under violet light. of a number of other pl ... | 1979 | 91243 |
| more than one antigen contributes to the immunogenicity of neisseria gonorrhoeae in the guinea pig chamber model. | gonococci adapted to growth in guinea pig chambers [strain bs4 (agar)] were predominantly smooth organisms and produced a type-specific antigen. a vaccine prepared by treating these gonococci with formalin, protected guinea pig chambers against homologous challenge in contrast to a similarly treated laboratory strain (bsdh) which had been selected in vitro from the same parent strain and which did not produce the type-specific antigen. surface washes of bs4 (agar) contained the type-specific ant ... | 1979 | 91661 |
| hapten-specific t-cell responses to 4-hydroxy-3-nitrophenyl acetyl. ii. demonstration of idiotypic determinants on suppressor t cells. | the ability of np-coupled syngeneic spleen cells to induce antigen-specific t-suppressor cells capable of binding to np-bsa-coated petri dishes and mediating transfer of specific suppressive activity to np was demonstrated. furthermore, in strains of mice bearing the ig-1b allotype, including sjl, and in (non-ig-1b x ig-1b)f1 hybrids, the np-specific suppressor cells also interferes with expression of immunity after priming with nip-bgg. anti-npb anti-idiotype antiserum plus complement treatment ... | 1979 | 92517 |
| qualification of estrogen binding variables in tissues of the immature rat. | | 1979 | 92743 |
| characterization of various horse thyroid forms of cyclic-nucleotide phosphodiesterase [proceedings]. | | 1979 | 92956 |
| education of mouse lymphocytes against human lymphoblastoid cell lines: specific recognition of determinants independent of serologically defined hla allotypes and epstein-barr virus-coded antigens. | | 1979 | 93053 |
| chlorpyrifos and 3,5,6,-trichloro-2-pyridinol: residues in the body tissues of cattle wearing chlorpyrifos-impregnated plastic ear tags. | | 1979 | 93609 |
| substance p as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation. | | 1979 | 93706 |
| [role of calcium in realization of nervous control during rna synthesis in skeletal muscles]. | the effects of ca2+ on the rna polymerase activity of the nuclei isolated from normal and denervated gastrocnemius muscles of the rabbit were studied. it was shown that 18 hrs after denervation the rna synthesis in vitro, ca2+ content and the ca, mg-atpase activity of the nuclei are decreased. after addition of exogenous ca2+ the incorporation of labelled utp into the nuclei is stimulated in the denervated muscle and is inhibited in the control. electrostimulation of the denervated muscle at the ... | 1979 | 94840 |
| [hepatitis b virus during pregnancy and its consequences in perinatology]. | | 1979 | 95065 |
| [primordial morphogenesis of the stato-acoustic ganglion of the inner ear in the mouse embryo. i. analysis of the early morphogenesis of 9-, 9 1/2- and 10-day-old embryos]. | | 1979 | 95244 |
| minor metabolism a xanthene dye by african giant rat (cricetomys gambianus, waterhouse). | in a continuation of our previous report (adekunle, 1978), we have carried out a comparative study on the metabolism of eosin (2, 4, 5, 7-tetrabromofluorescein), a xanthene, in 2 mammalian species, the albino rat (rattus norvegicus) and the african giant rat (cricetomys gambianus, waterhouse). the latter shows a minor metabolism of this dye compared with the former. the findings are discussed in relation to the disposition of erythrosine bs (tetraiodofluorescein) reported by other workers. | 1979 | 95515 |
| production and chemical studies of protease from bacillus subtilis (sh-6) egyptian strain. | bacillus subtilis (sh-6) egyptian strain, isolated from hides, gave the highest protease activity. luxurious growth and protease production were obtained by the use of a medium containing 8% of potato starch, 0,1 m of ammonium phosphate as carbon and nitrogen sources. results indicate that borate buffer exerted a deleterious effect on the protease production. comparing citrate and phosphate buffers, it was found that citrate gave lower protease activity than phosphate. there is a positive respon ... | 1978 | 98932 |
| pars plana vitrectomy as a primary treatment for acute bacterial endophthalmitis. | we successfully treated six patients with culture-proven acute bacterial endophthalmitis by a combination of emergency pars plana vitrectomy and the instillation of intravitreal antibiotics. all six patients regained satisfactory vision. | 1978 | 99040 |
| site dependence for topical absorption of nitroglycerin in rats. | | 1978 | 99511 |
| [microbiological characteristics of intestinal dysbacteriosis in acute leukemia]. | | 1978 | 101983 |
| isolation and characterization of a pulmonary glycoprotein from human amniotic fluid. | a glycoprotein of the molecular weight of 36 000 has been isolated from human amniotic fluid. the glycoprotein was found to contain sialic acid, galactose, mannose, fucose, glucosamine, hydroxyproline and relatively high amounts of glycine. end-group analyses resulted in a single nh2-terminal residue indicating that the glycoprotein was homogeneous. the data indicate that this unique collagen-like glycoprotein, which is immunologically identical to a major alveolar glycoprotein found in alveoli ... | 1978 | 103578 |
| sequences of mouse immunoglobulin light chain genes before and after somatic changes. | we have determined the nucleotide sequences of the germ line gene as well as a corresponding somatically mutated and rearranged gene coding for a mouse immunoglobulin lambdai type light chain. these sequencing studies were carried out on three eco ri-dna fragments which had been cloned from balb/c mouse embryos or a lambdai chainsecreting myeloma, h2020. the embryonic dna clone ig 99lambda contains two protein-encoding segments, one for the majority of the hydrophobic leader (l) and the other fo ... | 1978 | 103630 |
| influence of adrenergic amines on mesenteric haemodynamics in the pig. | | 1979 | 106590 |
| [standardization of the seeding material in producing live anthrax vaccine]. | technology of obtaining dry concentrated seeding material of the anthrax bacillus sti-1 vaccine strain was worked out. the use of dry seeding material for making dry anthrax vaccine rendered the preparations obtained more standard, reduced the time required for their production, led to increase of akm-sh productivity, and to greater profitability of the vaccine production. the vaccine preparations obtained with the use of dry seeding material did not differ from control by immunogenicity. | 1978 | 106609 |
| evidence for the location of high mobility group protein t in the internucleosomal linker regions of trout testis chromatin. | antibodies against the trout testis non"histone chromosomal protein, high mobility group protein t (hmg-t), have been elicited in goats. the antiserum was shown to be specific for hmg-t and did not cross-react with histone 1 or with the other two trout testis hmg proteins, h6 and ubiquitin. purified anti-hmg-t igg was used to determine the location of hmg-t within chromatin subunits separated on sucrose gradients. binding of fluorescent labeled anti-hmg-t to these subunits clearly supports the n ... | 1979 | 107172 |
| a trial of minocycline given after exposure to prevent gonorrhea. | in a prospective evaluation of antibiotic prophylaxis against gonorrhea, 1080 men were given 200 mg of oral minocycline or placebo after sexual intercourse with prostitutes in a far eastern port. later, at sea, gonococcal infection was detected in 57 of 565 men given placebo and 24 of 515 men given minocycline (p less than 0.001). minocycline prophylaxis completely prevented infection by gonococci susceptible to 0.75 microgram or less of tetracycline per milliliter, reduced the risk of infection ... | 1979 | 107450 |
| [phagocytosis of group a haemolytic streptococci by mouse macrophages. comparison of preliminary infection of animals and degree of virulence of the strain (author's transl)]. | with the aim of studying immunological reactions associated with experimental streptococcal diseases, we have developed an in vitro technique for following phagocytosis of streptococci by peritoneal macrophages of mice. by this means we have been able to show that the rate of phagocytosis of streptococci by "normal" macrophages is inversely correlated to the degree of virulence of the strain. on the other hand, the rate of phagocytosis of the virulent strain is increased 10 times when the macrop ... | 1975 | 126542 |
| elementary particles in isolated rat liver and spleen nuclear membranes. | elementary spherical particles similar to those described in the mitochondria are found in isolated rat liver and spleen nuclear membranes. the particles are characterized by electron microscopy of sections and preparations negatively stained with phosphotungstic acid or with the atpase histochemical reaction product. the particles exhibit adenosine triphosphatase activity and have a mushroom-like shape with a sphere about 85-90 angstrom in diameter attached to inner face of the inner nuclear me ... | 1975 | 126876 |
| [ototoxicity of spectinomycin (author's transl)]. | spectinomycin is an aminocyclitol antibiotic, but different in chemical structure from other aminocyclitol antibiotics such as streptomycin, kanamycin and gentamicin. spectinomycin clinically has been proven to be highly effective in the intramuscular single-dose treatment of gonorrhea. according to novak et al. (1974), all evidence from pharmacological and clinical efficacy studies to date indicates that spectinomycin is free from ototoxic effects at the dose levels recommended for single-dose ... | 1976 | 135100 |
| bulbourethral gland infections in mice associated with staphylococcus aureus. | | 1976 | 135128 |
| [vitamins k and e and the functional state of connective tissue]. | the function of the connective tissue in the skin of albino rats with the vitamin k deficiency was studied. changes both in the cellular elements and in the fibrous structures (deranged differentiation of cellular elements, changes in the collagenformation, accumulation of acid mucopolysaccarides, etc.) were revealed. all of the mentioned changes are eliminated not only by introduction of vicasol, but also by that of alpha-tocopherol. | 1976 | 135412 |
| the role of the pituitary in acne. | | 1976 | 138539 |
| fluorescence of human liver alanine aminopeptidase. | fluorescence of human liver alanine aminopeptidase has been attributed to tryptophan fluorescence. the fluorescence maximum is at 330 nm, 20 nm lower than that for free tryptophan, suggesting that most of the enzyme tryptophans are in a nonpolar environment and are shielded from solvent. quenching of enzyme fluorescence by iodide, pyridine, and n-methyl nicotinamide also demonstrates that enzyme tryptophan residues are largely buried and inaccessible to solvent. those accessible are in negativel ... | 1977 | 143669 |
| con a-inducible suppression of mlc: evidence for mediation by the th2 + t cell subset in man. | human peripheral lymphoid cells pretreated with concanavalin a for 48 hr can markedly suppress the proliferative response of untreated autologous lymphoid cells in mlc. isolation studies with sephadex g-200 anti-f(ab')2 affinity chromatography, nylon adherence, and e rosetting indicate that the con a-induced suppressor cell is a t cell. further fractionation into th2+ and th2- cell subsets with an equine-anti th2 serum show that both subsets can be activated by con a to an equivalent degree. aft ... | 1979 | 156215 |
| the storage lipids in tangier disease. a physical chemical study. | the physical states and phase behavior of the lipids of the spleen, liver, and splenic artery from a 38-yr-old man with tangier disease were studied. many intracellular lipid droplets in the smectic liquid crystalline state were identified by polarizing microscopy in macrophages in both the spleen and liver, but not in the splenic artery. the droplets within individual cells melted sharply over a narrow temperature range, indicating a uniform lipid composition of the droplets of each cell. howev ... | 1977 | 193870 |
| studies of the histochemistry, ultrastructure, motor innervation, and regeneration of mammalian intrafusal muscle fibres. | | 1976 | 137430 |
| localization and possible role of an adenosine triphosphatase in chlorobium thiosulfatophilum. | 1. evidence is presented that the atpase activity detected in cell extracts of chlorobium thiosulfatophilum is bound to the cytoplasmic membrane rather than to the chlorobium vesicles. 2. the activity of this atpase is inhibited in vitro by various carbodiimides, phloridzin and sodium azide. 3. the apparent km for atp is approximately 0.2 mm and the enzyme shows product inhibition by adp. 4. photophosphorylation, characterized in vivo, is inhibited by many of the compounds that inhibit the atpas ... | 1976 | 134890 |
| [effect of bay 2222 in the "pour-on" method on dictyocaulus and trichostronglides in cattle]. | | 1975 | 127580 |
| complement-induced modifications in membrane fluidity: studies with resealed and glutaraldehyde-treated erythrocyte membrane ghosts. | | 1978 | 207778 |
| [comparison of various leukemia virus antigen components in the immunodiffusion test for the detection of specific antibodies in serum and plasma]. | | 1978 | 211021 |
| comparison of interferon action in interferon resistant and sensitive l1210 cells. | translation inhibition, leu-trna aminoacylation and double-stranded rna and atp dependent phosphorylation were examined in interferon-treated and control cell-free lysates of leukaemic mouse l 1210 r and l 1210 s cells. no differences were observed between the respective interferon-treated and control cell-free extracts, except for the presence of an enhanced 67k dalton phosphoprotein fraction in interferon-treated l 1210 s cell-free extracts. in non-responding cell-free lysates, the lack of sti ... | 1978 | 212514 |
| [effect of some antidiuretic agents on the polyuria-polydipsia provoked by alcohol]. | the authors have studied in the dog--normal or diabetic insipidus after hypothalamic lesion--submitted to oral ingestion of ethanol the effects of a few antidiuretic drug: chlorpropamid, atromid-s, carbamazepin and carisoprodol. the carisoprodol only can reduce the diuresis and the drinking provoked by ethanol. | 1975 | 126784 |
| membrane receptor function and the loss of glucagon-stimulated adenylate cyclase activity in hepatomas. | plasma membranes were prepared from homogenates of two well differentiated hepatomas (morris rat 7787 and dalton mouse 9815), two poorly differentiated hepatomas (morris rat 7288-c and dalton mouse 129), and normal liver. adenylate cyclase activity and [125i]iodoglucagon binding were measured in the plasma membrane preparations over a wide range of glucagon concentrations. nether glucagon-stimulated adenylate cyclase activity nor [125i]iodoglucagon binding could be detected in the poorly differe ... | 1978 | 217618 |
| [clinical conference: hl-a antigens in chronic myeloid leukemia]. | | 1975 | 126439 |
| gastrin-related compounds and their effect on gastric-acid and gastrin output in the dog. | | 1975 | 123975 |
| inherited immunodeficiency in chickens: a model for common variable hypogammaglobulinemia in man? | | 1977 | 303448 |
| [ring-20 chromosome: a new syndrome]. | a comparative study of five observations of a r (20) syndrome characterized by facial dysmorphism, the absence of severe malformations, and rather late onset of encephalopathy and seizures. | 1977 | 305753 |
| apparatus for uniaxial testing of soft human tissues in vitro. | | 1978 | 309051 |
| [basophils in generalized rash (polák & turk) (author's transl)]. | | 1978 | 309957 |
| immunological heterogeneity of haemophilia b: a multicentre study of 98 kindreds. | an electroimmunoassay with a precipitating rabbit anti-human factor ix antiserum and an inhibitor neutralization assay with a non-precipitating homologous antibody were used to measure factor ix antigen (ix:ag) in 117 patients from 98 kindreds with haemophilia b; and to investigate in a mixed population the incidence of different immunological types of the disease. although the two assays showed an excellent correlation, the electroimmunoassay was selected for its simplicity as a criterion for c ... | 1978 | 103564 |
| [mechanisms of adaptation of tissue growth to the entrance of exogenous substances into the body]. | | 1979 | 373284 |
| [the effect of prolonged irradiation and of certain radioprotective agents on glycosaminoglycans in the rat]. | | 1978 | 101997 |
| nature's infant nutrition. breast feeding: a means of imparting immunity? | | 1978 | 99622 |
| [diagnosis of vibriosis in bulls at breeding stations through lavages of the artificial vagina]. | the objective of the study was to test the suitability of lavages of artificial vaginas which are used for collecting ejaculate for diagnosing the campylobacter fetus subsp. fetus germs. according to the results of the investigation this method may be considered equal to the method of lavages of the prepuce. however, it is important to point out the advantages: it eliminates the danger of an accident, it enables quality lavage in the laboratory. to caputure the campylobacter fetus the filtration ... | 1978 | 96573 |
| role of nucleic acids and cytoskeleton in nuclear refringence phenomenon (nrp) of human peripheral blood lymphocytes. | nuclear refringence is a phenomenon visible by light microscopy that is correlated with lymphocyte maturation and activation. the present study, in employing isolated nuclei as well as intact lymphocytes, confirms the nuclear basis of the phenomenon. enzymatic degradation of nucleic acids in isolated nuclei attenuates refringence, providing presumptive evidence for the involvement of chromatin in refringence. cytoplasmic events involving rna and protein synthesis and microtubular, but not microf ... | 1979 | 95408 |
| primary structure of yeast proteinase b inhibitor 2. | the complete amino acid sequence of yeast proteinase b inhibitor 2 (ib2) was determined to be h3n+-thr-lys-asn-phe-ile-val-thr-leu-lys-lys-asn-thr-pro-asp-val-glu-ala-lys-lys-phe-leu-asp-ser-val-his-his-ala-gly-gly-ser-ile-leu-his-glu-phe-asp-ile-ile-lys-gly-tyr-thr-ile-lys-val-pro-asp-val-leu-his-leu-asn-lys-leu-lys-glu-lys-his-asn-asp-val-ile-glu-asn-val-glu-asp-lys-glu-val-his-thr-asn-coo-. elucidation of the primary structure was enabled by automated edman degradation and cooh-terminal hydro ... | 1979 | 387783 |
| isoelectric focusing of oligopeptides: detection by specific stains. | by using ultrathin (350 micrometers) polyacrylamide gels, which at the end of the fractionation are pasted to filter paper and dried in an oven at 110 degrees c, and after isoelectric focusing it has been possible to detect oligopeptides in the di- to tetradecapeptide range, which could not be detected by protein staining techniques. this is achieved by developing a series of specific stains for the following amino acids: arg, tyr, his, trp, met and cys. except for met and cys, the detection lim ... | 1979 | 95344 |
| hemodynamic consequences of administration of phentolamine or nitroprusside with dopamine in the dog. | dopamine was administered intravenously to two groups of anesthetized dogs at rates of 2.5, 5, 10 and 20 micrograms/kg/min. after the 20 micrograms/kg/min infusion, mean arterial pressure, heart rate, renal blood flow, mean pulmonary arterial pressure, and left ventricular filling pressure were increased. the dopamine infusion was continued in both groups of animals. in group i phentolamine was administered at rates of 2.5, 5, and 7.5 micrograms/kg/min; in group ii sodium nitroprusside at rates ... | 1979 | 94404 |
| exposed sulphydryl groups of types of haemoglobin during human ontogenesis. | | 1978 | 94245 |
| [first results obtained in man with ethinyl estradiol sulfonate given for various indications (proceedings)]. | | 1979 | 515140 |
| [response of certain laboratory animals to being fed an ocean fish, the ruvette]. | | 1979 | 516605 |
| [effect of the emissions caused by the cement industry on biochemical and morphological parameters in rabbits]. | | 1979 | 516811 |
| isolation of corynebacterial enzymes from cultivation media by gel filtration and ion-exchange chromatography. | | 1979 | 524393 |
| experimental s. mansoni infection in mice. blood white cells, serum proteins, glycemia and blood urea in various stages of the infection. | | 1979 | 545638 |
| [fluctuation of t-cell and b-cell populations in lymph nodes of various locations following immunization]. | | 1975 | 1082515 |
| enhancement of feline leukemia virus-induced leukemogenesis in cats exposed to methylnitrosourea. | the effect of methylnitrosourea (mnu), a potent resorptive carcinogen, was evaluated for its influence on the susceptibility of adult cats to infection and induction of oncornavirus disease by feline leukemia virus (felv). young adult cats at an age previously demonstrated to be highly resistant to felv, were injected intravenously with moderately toxic doses (15-20 mg/kg) of mnu alone or with infections felv (rickard strain). following exposure to virus and chemical, cats were monitored for ant ... | 1979 | 93586 |
| incubation of 3,4-benzo(s)pyrene with serum fractions: effect on tumor production. | the effect on tumor formation in swiss mice of incubation of 3,4-benzo(a)pyrene [b(a)p]either with saline or saline containing serum, gamma-globulin or albumin (form mouse or rabbit) was investigated. a high incidence of sarcomas (80--100%) was obtained in swiss mice by b(a)p incubated in vitro with rabbit serum, rabbit gamma-globulin, mouse serum, mouse gamma-globulin, and saline. a lower incidence (60--65%) was obtained with b(a)p incubated with mouse serum, mouse albumin, and rabbit albumin. ... | 1979 | 93109 |
| endogenous prostaglandin release contributes directly to coronary artery tone. | an in vitro coronary artery preparation of beef heart was found to synthesize and release continuously large amounts of a prostaglandin of the e type. inhibition of prostaglandin synthesis with aspirin, indomethacin, or eicosa-5,8,11,14-tetraynoic acid induced a sustained contraction of the coronary artery, and pretreatment with indomethacin diminished markedly the output of prostaglandin into the bathing medium. it appears that prostaglandin e1, generated from within the vessel wall itself, may ... | 1975 | 1175084 |
| properties of an fc gamma-binding protein isolated from human leukemic b cells. | a selectively fc gamma-binding protein was isolated from purified and radioiodinated cell membranes from two cases of b-type chronic lymphocytic leukemia and one case of b-type prolymphocytic leukemia by binding to igg aggregates, horseradish peroxidase-anti-peroxidase igg complexes, and sheep erythrocyte membrane sheets densely coated with igg. this protein could not be isolated from the cell membranes of an fc gamma-receptor-negative chronic lymphocytic leukemia of the t type or from membranes ... | 1979 | 91652 |
| failure to demonstrate degradation of (4-14c) cholesterol to volatile hydrocarbons in rats and in human fecal homogenates. | the inability of previous workers to recover completely the radioactivity from ingested [4-14c] cholesterol has led to the hypothesis that the colonic flora of some individuals degrade the sterol nucleus to volatile hydrocarbons, particularly ch4. in the present investigation, the production of radioactive volatiles was measured following incubation of [4-14c] cholesterol with 8 human fecal homogenates or after instillation of the labeled sterol into the cecum of 3 rats housed in a closed rebrea ... | 1975 | 1196016 |
| [the possibility of influenza virus reproduction in cultures of insect cells]. | | 1975 | 1214662 |
| attenuated, streptomycin-dependent salmonella typhi oral vaccine: potential deleterious effects of lyophilization. | four studies were done with streptomycin-dependent salmonella typhi as an oral, attenuated vaccine. studies 1 and 3 employed freshly harvested vaccine, whereas studies 2 and 4 involved lyophilized vaccine. five to eight doses (3 x 10(10)-10(11) organisms/dose) were given; oral streptomycin (1.0 g) was administered concomitantly in studies 2 and 3, with only two of the doses of vaccine in study 1, and was not given in study 4. no adverse reactions were encountered in 179 vaccinated men, and 94% o ... | 1976 | 1262709 |
| [changes in the activity of succinate dehydrogenase in the cells of different brain structures under the effect of uhf field of low intensity]. | | 1976 | 1274298 |
| changes in the spectrum of organisms causing respiratory tract infections: a review. | over the last decade, the spectrum of organisms causing community-acquired acute lower respiratory tract infections has changed. streptococcus pneumoniae now causes approximately 30% of outpatient acute pneumonia-less than in former decades-whereas mycoplasma pneumoniae is found in both young and elderly patients. the enterobacteriaceae and staphylococcus aureus are now seen more frequently as respiratory tract pathogens in community-acquired pneumonia patients, and they are the major organisms ... | 1992 | 1287613 |
| reverse transcriptase mediated binding of primer trna to the viral genome. | a complex between trnatrp (beef) and 35 s rna from avian myeloblastosis virus is obtained when the mixture is preincubated in the presence of reverse transcriptase at 35 degrees c. the trna-rna complex is active in initiating dna synthesis catalyzed by reverse transcriptase. the interaction of trna with reverse transcriptase involves the partial unwinding of the acceptor stem of trna, as evidenced by nuclease digestion with rnaase t1 and micrococcal nuclease. when trna2glu (coli), having a high ... | 1979 | 91158 |
| definition of two ld antigens in rhesus monkeys. | two rhesus (macaca mulatta) monkey lymphocyte-defined (ld) antigens have been identified using two typing cells as stiumlators in a one-way mixed leukocyte culture (mlc) assay. an analysis of the genetic behavior of these ld antigens in six rhesus monkey families revealed that both antigens were linked with rhla. one probable recombinant indicated that the ld locus lies outside the two known rhla-sd loci and the locus which controls the serum protein, properdin b(bf). these two antigens, ld1 and ... | 1979 | 87026 |
| expression and release of neuroregulators during development: monoamines and neuropeptides. | the turnover of catecholamines (ca) was determined in the adrenal medulla and brain of rat fetuses and pups. in general we found a considerable increase soon after birth. the expression of mrna for ca-synthesizing enzymes was also considerably enhanced in the adrenals shortly after birth. furthermore, we demonstrated increased expression of neuropeptides after birth, increased synthesis of mrna encoding for neuropeptide y in the adrenals 24 h after birth; and considerable activation of the subst ... | 1992 | 1306802 |
| prostatic binding protein. a steriod-binding protein secreted by rat prostate. | rat prostatic cytosol contains a high concentration of a prostatic binding protein with peculiar steroid-binding properties. indeed, in spite of a relatively low affinity, charcoal adsorption can be used for its measurement. furthermore, the binding is not specific for particular steroids and increases very strongly after delipidation. in delipidated cytosol the concentration of the binding site is 3.1 micronmol/g protein and the apparent affinity for pregenolone 1.7 x 10(6) m-1. the high concen ... | 1977 | 21076 |
| agar plate screening procedure for cyclic adenosine 3',5'-monophosphate and inhibitors of cyclic nucleotide phosphodiesterase. | a procedure is described for the semiquantitative measurement of cyclic adenosine 3',5'-monophosphate (camp) and detection of inhibitors of camp phosphodiesterase by an agar plate test. the assay organism was an adenyl cyclase-deficient mutant derived from escherichia coli hfrh. in the presence of an acid base indicator, acid production from barbohydrate metabolism was observed as a yellow zone around filter paper disks containing camp. since yellow zone formation reflects the presence of camp, ... | 1977 | 201216 |
| the pathogenicity of drug-resistant variants of herpes simplex virus. | | 1992 | 1317602 |
| hetrazepine paf antagonists. | hetrazepines such as web-2086 or web-2170 are potent, specific, competitive paf antagonists binding at the same site as the paf molecule. despite their structural similarity to known hypnotic drugs they lack hypnotic actions. they almost certainly bind not only cell-surface but also intracellular paf receptors, which may explain their activity in disease models in which adherence of neutrophils or other cell types to the vascular endothelium plays a role. | 1992 | 1326346 |
| results of intermittent treatment of growth hormone deficiency with human grwoth hormone. | the growth in stature of two groups of growth hormone deficient children has been compared. the frist group received intermittent treatment with human growth hormone (hgh), 1 year on, 1 year off, subsequent years on; the second group received continous treatment. this latter group had a significantly better mean growth response. the reduction in treatment velocity in years subsequent to the first was not prevented by the year off treatment, the mean velocity of the intermittent group in their 3r ... | 1977 | 194914 |
| the role of polyamines in the aminoacyl transfer ribonucleic acid synthetase reactions. demonstration of the requirement for magnesium ion and a secondary stimulatory effect of spermine. | spermine and related polyamines have been reported to substitute for mg2+ in the aminoacylation of trna catalyzed by aminoacyl-trna synthetases, but not in the atp-pp-i exchange reaction. such observations have led some workers to propose that these reactions proceed via a concerted mechanism rather than the usual two-step mechanism involving an aminoacyladenylate intermediate. in an attempt to elucidate the mechanism of the spermine effect on acylation and exchange, both reactions were re-exami ... | 1975 | 165187 |
| characterization of guanosine diphospho-d-mannose dehydrogenase from pseudomonas aeruginosa. structural analysis by limited proteolysis. | alginate is believed to be a major virulence factor in the pathogenicity of pseudomonas aeruginosa in the lungs of patients suffering from cystic fibrosis. guanosine diphospho-d-mannose dehydrogenase (gdpmannose dehydrogenase, ec 1.1.1.132) is a key enzyme in the alginate biosynthetic pathway which catalyzes the oxidation of guanosine diphospho-d-mannose (gdp-d-mannose) to gdp-d-mannuronic acid. in this paper, we report the structural analysis of gmd by limited proteolysis using three different ... | 1992 | 1370473 |
| immune response-associated antigens on mouse leukemia cells. ii. anti-ia sera inhibit the mlr reaction between normal gr spleen cells and syngeneic spleen cells of grsl tumor-bearing mice. | mitomycin c-treated ascites cells of ia antigen-positive grsl14 tumor cells and spleen cells from grsl14 tumor-bearing mice stimulated lymphocyte proliferative responses in normal syngeneic gr spleen cells. furthermore, mitomycin c-treated t cells purified from spleen cells of tumor-bearing mice also stimulated normal gr spleen cells. anti-ia sera inhibited the stimulating ability of tumor cells and of spleen cells of tumor-bearing mice. these data suggest a role for i region gene products in im ... | 1978 | 151953 |
| controlled-test evaluation of fenbendazole against natural infections of lungworms in calves. | | 1978 | 150090 |
| the use of tryptophan fluorescence to determine the stability of igg binding proteins based upon the b domain of protein a from staphylococcus aureus. | | 1992 | 1426572 |
| influence of cyproterone acetate on phosphatases & dehydrogenases of rat testis. | | 1977 | 201561 |
| contribution of the morris hepatomas to the biochemistry of cancer--establishment of the phenotypic heterogeneity of neoplasms in vivo. | | 1977 | 205099 |
| a comparative evaluation of chicken embryo tracheal organ cultures for the assay of avian infectious bronchitis virus. | | 1978 | 214447 |
| a thymus cell marker in murine leukemia virus-induced lymphomas of rats. | a specific marker for an immature population of thymus cells in the rat was shown by the rosette formation between thymus cells and guinea pig erythrocytes. this method was used to classify murine leukemia virus-induced rat lymphomas. eight of nine gross virus-induced rat lymphoma lines, which originated in the thymus, formed rosettes; whereas friend, rauscher, or moloney virus-induced rat lymphoma lines, which originated in either the thymus, spleen, or mesenteric lymph nodes, did not form rose ... | 1979 | 225024 |
| loss of integrated viral dna sequences in polyomatransformed cells is associated with an active viral a function. | rat cells transformed by polyoma virus contain, in addition to integrated viral dna, a small number of nonintegrated viral dna molecules. the free viral dna originates from the integrated form through a spontaneous induction of viral dna replication in a minority of the cell population. its presence is under the control of the viral a locus. to determine whether the induction of free viral dna replication was accompanied by a loss of integrated viral dna molecules in a phenomenon similar to the ... | 1979 | 225038 |
| treatment of functional amenorrhea-galactorrhea with 2-bromoergocryptine. | the present study was undertaken to investigate not only the effectiveness of bromoergocryptine therapy in 13 women with amenorrhea-galactorrhea and hyperprolactinemia without evidence of organic pathology, but also to assess the value of pretreatment evaluation in predicting the response to therapy. sella turcica tomography, base line serum follicle-stimulating hormone, luteinizing hormone (lh), thyroid-stimulating hormone, t4, plasma cortisol levels, and the growth hormone reserve were normal ... | 1977 | 321260 |
| disappearance of cd4 antigen in a case of adult t cell leukaemia. | | 1992 | 1482666 |
| comparative ultrastructure of mycobacterium leprae and mycobacterium lepraemurium cell envelopes. | the structural properties of the cell envelopes of mycobacterium leprae and mycobacterium lepraemurium were investigated by freeze-fracture, freeze-etching, and negative-staining techniques. freeze-fracture split the cell wall and exposed the internal features of the peptidoglycolipid mycosidic filamentous network. the cell membrane was also split into two asymmetric faces. the external fracture face was characterized by linear arrays of intramembranous particles, whereas the protoplasmic fractu ... | 1979 | 374395 |
| mitochondrial protein-synthesizing machinery in saccharomyces cerevisiae grown in different metabolic conditions. variability of seryl-trna and alanyl-trna isoacceptor patterns. | 1. the isoacceptor patterns of mitochondrial seryl and alanyl-trnas from saccharomyces cerevisiae grown under different conditions and committed to fermentative or respiratory metabolism have been studied by reversed-phase chromatography. 2. an extensive variability of the chromatographic patterns of the four isoacceptors for serine and of the three isoacceptors for alanine has been observed as a function of carbon source and stage of growth, but the main differences were observed in the differe ... | 1979 | 381000 |
| [cryptococcosis in aids patients: a study of 19 cases]. | we discuss 19 cases of infection due to cryptococcus neoformans diagnosed in 438 aids patients admitted to our center (4%). fourteen of them showed meningitis confirmed by culture of c. neoformans in csf. clinical features were rather unspecific and disorders in csf parameters were non striking. the diagnostic techniques performed with best results were culture of c. neoformans and antigen determination, especially in serum. survival probability at one year was 75%. treatment response was good. ... | 1992 | 1626090 |
| isoleucyl transfer ribonucleic acid synthetase. steady-state kinetic analysis. | a steady-state kinetic analysis was conducted of the overall aminoacylation reaction catalyzed by isoleucyl-trna synthetase. the patterns of lineweaver-burk plots obtained indicated that trna adds to the enzyme only after isoleucyl adenylate formation and pyrophosphate release. these kinetic patterns were consistent with the bi-uni-uni-bi ping pong mechanism generally accepted for this aminoacyl-trna synthetase, but they could also be accommodated by a mechanism in which a second molecule of l-i ... | 1979 | 383140 |
| synthesis and properties of fluorescent nucleotide substrates for dna-dependent rna polymerases. | a new class of fluorescent nucleotide analogs which contain the fluorophore 1-aminonaphthalene-5-sulfonate attached via a gamma-phosphoamidate bond has been synthesized. both the purine and pyrimidine analogs have fluorescence emission maxima at 460 nm. cleavage of the alpha-beta-phosphoryl bond produces change in both the absorption and fluorescence emission spectra. the fluorescence of the pyrimidine analogs is quenched; cleavage of the alpha-beta-phosphoryl bond of the utp analog produces abo ... | 1979 | 387781 |
| analysis of high psa n-cam expression during mammalian spinal cord and peripheral nervous system development. | using a monoclonal antibody that recognizes specifically a high polysialylated form of n-cam (high psa n-cam), the temporal and spatial expression of this molecule was studied in developing spinal cord and neural crest derivatives of mouse truncal region. temporal expression was analyzed on immunoblots of spinal cord and dorsal root ganglia (drgs) extracts microdissected at different developmental stages. analysis of the ratio of high psa n-cam to total n-cam indicated that sialylation and desia ... | 1991 | 1769342 |
| [the molecular biology of aging -- 15: structure and function of the genetic apparatus in aging. ii. synthesis and metabolism of rna]. | with aging in different organs there are similar or tissue specific changes of the ribonucleic acids in respect of the quantity, the spectrum of different rna species and the metabolism of rna. among these processes the template function of the chromatin and the behaviour of the rna polymerases are important influencing factors. in aging the sensitivity of the rna synthesis against hormonal stimulation is decreased in the most cases. a survey about the results of many in vivo and in vitro experi ... | 1979 | 395770 |
| effect of spectrin on structure properties of lipid bilayers formed from mixtures of phospholipids. fluorescence and microcalorimetric studies. | effect of spectrin from human erythrocytes on structure properties of lipid bilayers formed from a mixture of phosphatidylethanolamine/phosphatidylserine (pe/ps) and/or phosphatidylethanolamine/phosphatidylcholine (pe/pc) was studied with the use of fluorescence and microcalorimetric methods. spectrin did not affect the order parameter of lipids in pe/ps vesicles. however, spectrin binding to liposomes did influence temperature, half-width and enthalpy of phase transitions in mixtures of dimyris ... | 1991 | 1769515 |