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immune response genes have a variable influence on the selection of antigenic foreign and self determinants of insulin.we studied the proliferative response of mouse t lymphocytes to determinants on ungulate insulins. the immunopotency of defined determinants on the molecule was found to be regulated by three factors: the immune response genes of the immunized mouse, the mode of presentation of insulin on cells or in adjuvant, and the intramolecular cooperativity between different determinants on the insulin molecule. autosensitization against self determinants was observed under specific conditions. these findi ...197991175
resonance raman spectroscopy of chlorophyll-protein complexes.resonance raman spectra of chlorophyll a (chl a) and of chl b were selectively obtained, at low temperature, from chlorophyll-protein complexes prepared from green and blue-green algae and from higher plants. antenna chl a in the chl a-p700-protein complexes (cp i) and in the light-harvesting chl a/b-protein complexes (cp ii gives resonance raman spectra extremely close in all their features to those previously obtained from intact cells and chloroplasts. in particular, the same multiplicity of ...1978110567
hydrolysis of erythrocyte membrane phospholipids by a preparation of phospholipase c from clostridium welchii. deactivation of (ca-2+, mg-2+)-atpase and its reactivation by added lipids.1. haemoglobin-free erythrocyte ghosts were prepared in 40 imosm bicarbonate buffer, ph 7.4, containing 1 mm edta (40 imosm/l mm edta). the ghost preparation was highly permeable on preparation but partially resealed on incubation in media containing ca-2+. 2. a partially purified preparation of phospholipase c from clostridum welchii caused an increase in observed mg-2+-atpase activity, reflecting a change in the permeability of the ghost to substrate. the phospholipase did not decrease mg-2+-a ...1975123773
activation and inhibition of the mg-ca-atpase from e. coli by mg2+ and ca2+.mgatp of caatp is the substrate of the mg-ca-atpase. at low mg2+- or ca2+-concentrations the atpase is activated by mg2+ or ca2+, the activator being essential for activity. at higher mg2+- or ca2+-concentrations the mg-ca-atpase is inhibited competitively. thus the real km is smaller than reported in the literature. h+ competes with mg2+ or ca2+ for the metal binding sites.1975126584
neurectoderm markers retained in phenotypical skeletal muscle cells arising from a glial cell line. 1979492321
effects of the antimicrobic tiamulin on seven gram-negative bacterial fish pathogens.in vitro and in vivo test were carried out with tiamulin and gram-negative bacterial pathogens of fish. determination of minimum inhibitory concentration for 51 strains of seven species of gram-negative bacterial pathogens showed that only strains of vibrio anguillarum were sensitive at 1.6-6.25 ppm, while the rest of test strains required 25- greater than 100 ppm. control of infection was not achieved when tiamulin was fed for 14 days at 5 or 50 mg/kg to rainbow trout (salmo gairdneri) experime ...19883127604
trimming sheep teeth. 19863739170
[animal models of abnormal bilirubin metabolism--gunn rat and corriedale sheep]. 19853903282
experimental ependymomas: in vivo and in vitro morphology. 19744140638
[leptotrichia buccalis--culture, biochemistry and antibiotics]. 19744154653
effects of immunizing turkeys with ovine luteinizing hormone. 19734199053
inhibitory action of carbodiimides on bacterial membrane atpase. 19704249016
an i pilus-determining r factor with anomalous compatibility properties, mobilizing a gentamicin-resistance plasmid. 19734579435
[how the length of bacterial flagella is determined in vitro? (author's transl)]. 19734582327
[brucellosis melitensis]. 19744831476
change in the template specificity of rna phage sp-replicase by the e. coli cell component. 19724559663
are plasma lipoprotein cholesteryl esters utilized for biliary cholesterol and bile acid production in man?studies were carried out to determine whether or not plasma lipoprotein cholesteryl esters are available to the liver for biliary cholesterol and bile acid production in humans with intact biliary tracts. six healthy males were given intravenous infusions of autologous high-density (d, 1.063-1.21; n = 2), low-density (d, 1.019-1.063; n = 2) or intermediate-density (d, 1.006-1.019; n = 2) lipoproteins that had been labelled in vitro with radioactive cholesteryl linoleate (n = 5) or cholesteryl ol ...19853999925
some alterations of lipid metabolism in spontaneously hypertensive rats in relation to the stage of hypertension. 19863749518
relations between brain and cognitive development.goldman-rakic reports important new data on cortical development in rhesus monkeys. some of her findings, especially concurrent cortical synaptogenesis, may be related to cognitive capacities that develop in infancy. the developmental pattern of concurrent synaptogenesis in rhesus is consistent with a straightforward model of relations between brain and cognitive development: concurrent synaptogenesis is hypothesized to lay the primary cortical foundation for a series of developmental levels in ...19873608642
protein sorting in yeast: mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway.we have devised a genetic selection for mutant yeast cells that fail to properly deliver the vacuolar glycoprotein cpy to the lysosome-like vacuole. this has allowed us to identify mutations in eight vpl complementation groups that result in aberrant secretion of up to approximately 90% of the immunoreactive cpy. other soluble vacuolar proteins are also affected by each vpl mutation, demonstrating that a sorting system for multiple vacuolar proteins exists in yeast. mislocalized cpy apparently t ...19863536126
severity of alcohol-induced deficits in rats during the third trimester equivalent is determined by the pattern of exposure.the pattern of alcohol exposure has been suggested to be an important determinant of fetal alcohol effects. rats were exposed to alcohol and reared artificially on postnatal days (pd) 4-10. a uniform alcohol exposure group received alcohol (6.6 g/kg/day) in 12 daily feedings (every 2 hrs) resulting in stable bacs below 100 mg/dl. a condensed alcohol exposure group also received 6.6 g/kg/day but the alcohol was concentrated in 4 of 12 daily feedings giving peak bacs above 400 mg/dl. condensed alc ...19873426716
[therapy of aids].therapeutic strategies in the management of aids should aim at an inhibition of the replication and spread of hiv; the reconstitution of immune functions; an effective chemotherapy of opportunistic infections and tumors; and the prevention of new opportunistic infections. at present, these goals can be only partially achieved and where beneficial therapeutic results are obtained they are only transient in nature. antiretroviral therapy and chemotherapy of infections have, however, resulted in so ...19882849247
a report on genetic registers. based on the report of the clinical genetics society working party. 1998106123
the microsomal glucose-6-phosphatase enzyme of human gall-bladder.microsomes isolated from adult human gall-bladders have for the first time been shown to contain specific glucose-6-phosphatase activity. the gall-bladder glucose-6-phosphatase enzyme has the same molecular weight (36,500 daltons) and similar immunological properties and kinetic characteristics to the hepatic microsomal glucose-6-phosphatase enzyme.19892547044
metabolic basis of catecholamine-induced water transport in everted gut sacs of mouse.1. catecholamine-induced water transport was measured using an everted gut sac technique. adrenaline, noradrenaline and isoprenaline induce dose-dependent increases in water transport by the proximal intestinal sacs. use of selective adrenergic agents revealed the possible involvement of alpha 1- and beta 2-receptors in mediation of catecholamine stimulation of water transport in this segment. 2. inhibition of glycolysis reduced the effect mediated through alpha 1-receptors, while the inhibition ...19911914249
thermogenic and hormonal responses to palatable protein and carbohydrate rich food.simultaneous variations of oxygen consumption, and plasma insulin and norepinephrine were measured during the postprandial cephalic and gastrointestinal phases of feeding in six human subjects following the ingestion of various nutrients. on alternative days the subjects were given foods (1280 kjoules) either rich in carbohydrates (sugar pie) or in proteins (fish). both nutrients produced an initial (0-40 min) enhanced thermogenesis and an early (2 min) cephalic insulin release. during that peri ...19911774019
expression of subunit ii of chloroplast h(+)-atpase in an escherichia coli mutant lacking subunit b of its h(+)-atpase.the dna of subunit ii of the h(+)-atpase from spinach chloroplast was expressed in escherichia coli. it was found that a high gene dose is lethal to e. coli. with a lower gene dose subunit ii was not able to substitute for the homologous subunit b in the e. coli atp synthase.19921449071
heat shock proteins of barley mitochondria and chloroplasts. identification of organellar hsp 10 and 12: putative chaperonin 10 homologues.tissue slices from barley seedlings were subjected to heat shock and metabolically labelled with [35s]methionine and [35s]cysteine. mitochondria and chloroplasts were isolated and shown to contain two novel heat shock proteins of 10 and 12 kda, respectively. the possibility that these proteins, like a mitochondrial 10 kda stress protein recently isolated from rat hepatoma cells [(1992) proc. natl. acad. sci. 89, in press] represent eukaryotic chaperonin 10 homologues is discussed.19921352261
[alpha fetoprotein in hemorrhagic ascitic fluid in a case of hepatocellular carcinoma]. 20154356944
proceedings: experience with the gregoir-type prostatectomy. 20154593229
[effect of inoculation on nitrogen fixation by chick pea, on its crop and protein content].active strains of rh. cicer were found to increase the crop of chick pea by 25--36%, the content of protein by 2--6%, and the content of total nitrogen in the roots by 1.7--2%. symbiotic fixation of nitrogen determined by a technique of "inoculation" varies within 40--60% depending on the activity of the strain. no correlation has been established between the effectiveness of the strains of nodule bacteria and the activity of their enzymes--dehydrogenases.19751214612
application of differential interference contrast with inverted microscopes to the in vitro perfused nephron.the study of in vitro perfused individual nephron segments requires a microscope which provides: (1) easy access to the specimen for measurement of cellular solute flux and voltage; (2) an image with high resolution and contrast; (3) optical sectioning of the object at different levels; and (4) rapid recording of the morphological phenomena. this paper describes an example of commercially available apparatus meeting the above requirements, and illustrates its efficiency. the microscope is of the ...1979522133
the roentgenological aspects of goldenhar's syndrome (oculoauriculovertebral dysplasia). 20164969296
[electrophoretic differences in the proteins of the species pseudomonas aeruginosa and pseudomonas denitrificans capable of oxidizing n-alkanes].pseudomonas aeruginosa and ps. denitrificans are capable of growing on n-alkanes, but differ in assimilation of higher and lower alkanes. the proteins of their cell-free homogenates were analysed by disc-electrophoresis in a system containing sds. the "preliminarily adapted" strain of ps. aeruginosa did not differ from the "non-adapted" to n-hexane strain, though both differed considerably from ps. denitrificans in the composition of protein spectrum. therefore, disc-electrophoresis of total pro ...1978106218
cell differentiation in isolated inner cell masses of mouse blastocysts in vitro: onset of specific gene expression.inner cell masses (icms) were isolated by immunosurgery from giant blastocysts formed by the aggregation of three morulae. a layer of endoderm cells formed on the outer surface of these primary icms in vitro. when this layer was removed by immunosurgery, a secondary endoderm layer formed. alphafetoprotein (afp) was used as a biochemical marker to characterize visceral endoderm formation in these cultured icms. the immunoperoxidase reaction on sections of icms cultured for intervals up to 120 h i ...197994085
effect of escherichia coli endotoxin on the developing rat liver. i. giant cell induction and disruption in protein metabolism. 197992781
the o antigenic relationships of kloeckera africana, salmonella aberdeen and escherichia coli o75.the immune sera for salmonella aberdeen (o11) and escherichia coli (o75) agglutinated kloeckera africana strain. the immune serum for k. africana agglutinated s. aberdeen (o11) and e. coli (o75) strains. absorption and agglutination cross-tests demonstrated common antigenic factor(s) in the tested yeast and salmonella o11 and e. coli o75 antigens.197992211
immunochemical evidence for multiple serotypes of bacteroides fragilis.an immunochemical comparison of outer membrane antigens obtained from five select and biochemically defined strains indicated that there are several serotypes of bacteroides fragilis. each strain was serologically defined by individual or by combinations of determinant groups composed of carbohydrates in the form of polysaccharides or glycoproteins. the carbohydrate constituents were tentatively identified as glucose, galactose, fucose, rhamnose, glucosamine, galactosamine, and traces of mannose ...197991622
psychopathic adaptations in the vulnerable patient.the purpose of this paper is to discuss the fluidity of symptoms that a group of psychiatric patients presents during the passage of time. although clinically recognizable and worthy of attention, this fluctuation makes the illness difficult to conceptualize under a definitive diagnostic category. such a dilemma is very familiar to the hospital psychiatrist. the authors present a case to illustrate the fluidity of symptoms manifested by a patient throughout the course of her illness. awareness o ...20123359395
localisation of nucleolus-organizing regions in interphase cells.a technique based on the use of silver solutions, which selectively stains the nucleolus-organising regions (nors) in chromosomes, was applied to interphase ehrlich tumour cells. the results indicate that nucleolar fibrillar centres correspond to the nors.199991444
[activities of a home helper. 12. re-evaluation of the home care system]. 1998106177
new small proteins associated with dna-dependent rna polymerase of escherichia coli after infection with t4 phage. 19744595844
[topographic analysis of areas of negative and positive reinforcement in the central grey matter of the rat (author's transl)]. 19744593161
glossary of terms for thermal physiology. 20164765838
conversion of d-mannuronolactone into d-mannaric acid in mammalian systems. 19694309696
[biochemical effects of continuous and discontinuous muscular work (interval work)]. 20164720306
differential diagnosis and therapy of hyperketonemic state.detection of ketone bodies in the urine or plasma may be used as a rapid, inexpensive diagnostic approach. understanding the causes of hyperketonemia can lead to identification and appropriate therapy for the underlying cause. at least one urinary ketone measurement should be a routine procedure in all severely ill patients in whom a complete understanding of the underlying pathological processes is not present.1998107340
total parenteral nutrition. 1998107267
maturation of auditory brainstem potentials in neonates and infants.auditory brainstem evoked potentials (abp) were recorded in 59 healthy neonates and infants whose age ranged from 3 days to 18 months (6 age groups). latencies of individual waves and the interpeak latencies (ipl) of i-iii, iii-v and i-v were analysed. a different maturational pattern was observed in the pontomedullary and the pontomesencephalic segments of the brainstem. latencies of all waves except wave i were longer in male than in female babies. establishment of normative data related to th ...20144030233
[organization of medical and health-balneological assistance to invalids of the great civil war]. 1998124671
nutrient oxidation patterns and protein metabolism in lean and obese subjects.the immediate metabolic response to eating has been compared in a group of grossly obese subjects (w/h2 = 45) with that in lean controls (w/h2 = 22). dietary intake of energy for obese subjects was based on their estimated basal energy expenditure for ideal body weight (given at an hourly rate of 3 x bmr over a 4-h period). lean subjects were measured twice: control 1 with the same intake of energy as the obese in terms of ideal body weight and control 2 with the same energy intake in relation t ...20072228398
origin of immune diversity: genetic variation and selection. 20143927822
spinal stabilization. an introduction to cotrel-dubousset instrumentation. 20133650047
a novel mitotic spindle pole component that originates from the cytoplasm during prophase.several unique aspects of mitotic spindle formation have been revealed by investigation of an autoantibody present in the serum of a patient with the crest (calcinosis, raynaud's phenomenon, esophageal dysmotility, schlerodacytyly, and telangiectasias) syndrome. this antibody was previously shown to label at the spindle poles of metaphase and anaphase cells and to be absent from interphase cells. we show here that the serum stained discrete cytoplasmic foci in early prophase cells and only later ...20123536956
a novel mitotic spindle pole component that originates from the cytoplasm during prophase.several unique aspects of mitotic spindle formation have been revealed by investigation of an autoantibody present in the serum of a patient with the crest (calcinosis, raynaud's phenomenon, esophageal dysmotility, schlerodacytyly, and telangiectasias) syndrome. this antibody was previously shown to label at the spindle poles of metaphase and anaphase cells and to be absent from interphase cells. we show here that the serum stained discrete cytoplasmic foci in early prophase cells and only later ...20123536956
[ventricular premature systoles causing ventriculophasic sinus arrhythmia (author's transl)]. 200092108
roentgenologic analysis of 62 cases of mikulicz-sjögren's syndrome. 2000110551
david baltimore responds. 20072721854
david baltimore responds. 20072721854
[excretion of porphyrin precursors, aminolevulinic acid and porphobilinogen, in normal individuals]. 20133736172
[catheterisation of the internal jugular vein for parenteral nutrition (author's transl)].the technique consists of surgical exposure of the vein, its isolation by two threads and the introduction of a soft prethoracic exit. this technique avoids the complications inherent in any blind puncture of a large vessel. by virtue of the type of catheter (soft silicone) and the long subcutaneous course. it may be left in place for more than a month.1998106363
combination chemotherapy of advanced, diffuse, non-hodgkin's lymphoma: results with cyclo-phosphamide, adriamycin, vincristine, prednisone, and bleomycin (chop-bleo). 200192513
[enzymology of the cornea. ii. histochemical part]. 2003168975
pharmacokinetics of 99mtc(sn)- and 131i-labeled anti-carcinoembryonic antigen monoclonal antibody fragments in nude mice.the biodistribution, radioimmunoimaging, and high pressure liquid chromatography activity profiles of 99mtc(sn) and 131i-labeled anti-carcinoembryonic antigen monoclonal antibody fragments were compared. nude mice, bearing specific (colon carcinoma, ls174t) and nonspecific (pancreatic carcinoma, mia) xenografts were given injections of the respective radiolabeled antibody fragments and also of irrelevant 125i-labeled antibody fragments (mopc-21). the animals were imaged at 24 h after being given ...20093815365
relationship of radioimmunoassay to biological assay. 20165071380
cefaclor therapy for specific upper respiratory tract infections: pharyngitis, purulent rhinitis, laryngotracheitis. 20113072085
[vaccination against smallpox in patients with nonspecific lung diseases, with special reference to lung cancer]. 20124802735
[bone formation in bone marrow organ cultures].bone tissue composed of typical bone trabeculae containing ground substance with incorporated osteogenic cells and osteoblast layer was formed in organ cultures of bone marrow obtained from adult mice. electron microscopic properties of the bone formed in vitro were identical to those of the bone tissue in vivo. the mineralization of the bone took place only in the presence of na-beta-glycerophosphate in the culture medium.20133697499
[cardiac adaptation and compensation mechanisms and their disorders in the contractile insufficiency of chronically strained heart]. 20144252821
fine structure of the lysozyme gene of bacteriophage t4b. 20144817607
[incorporation of social interests of handicapped into national administration activities--experiences in the eisenach district]. 20144262008
limax amoebae in five swimming pools in stockholm. 20144836178
lockers provide 24-hour garment service. 20154683176
red blood cell deformability and the prostaglandins. 20154729605
red blood cell deformability and the prostaglandins. 20154729605
ultrastructure of adult epidermal cells in monolayer culture. 20154551263
coronary arterial stenosis, angina pectoris and atypical coarctation of the aorta due to nonspecific arteritis. treatment with aortocoronary bypass graft. 20154542026
[structures of pathways and centers of pain sensitivity. morphological and functional bases of analgesic surgery]. 20154299903
the care of the psychiatrically disturbed elderly patient in the community. 20165099947
the story of the manchester surgical society. 20164933708
a study on suicide. 20164850331
the psychology of rehabilitation. 200091902
emergency abdominal surgery in the aged.the results of 375 emergency abdominal operations in elderly patients over the age of 75 years are presented and discussed in detail. there has been a fourfold increase in the population over the age of 75 years in england and wales during the 60-year period from 1911 to 1971. the overall mortality of these patients of 31-7 per cent is unrelated to the age of the patient, but appears to be directly related to the severity of the surgical condition and to cardiorespiratory complications. our appr ...20051087575
[change in heart function in duchênne de boulogne myopathies at the severe progressive stage].left ventricular function was studied in 15 patients with rapidly progressive duchenne de boulogne muscular dystrophy. only one patient had a previous history of cardiac failure. all patients had typical electrocardiographical changes. haemodynamic and angiographic investigation was performed in all patients. three groups of patients were distinguished according to angiographic criteria : group i comprising 7 normal patients. group ii comprising 4 "intermediary" patients, and group iii of 4 pati ...1998106797
[reno-coeliac steal phenomenon: the inferior phrenic and supra-renal arteries as collaterals for the coeliac trunk (author's transl)].if the known collateral pathways for a stenosed or occluded coeliac trunk are not avialable whether for anatomical of haemodynamic reasons, a collateral circulation can be established through the suprarenal and inferior phrenic arteries to provide a significant flow. this is particularly so if the inferior phrenic artery arises from the coeliac trunk distal to the point of occlusion. the development of a reno-coeliac steal phenomenon or steal syndrome may then be expected, particularly if the ma ...1998124681
effects of stimulus frequency on the blink reflex during rest and a task.blink reflexes were studied in 84 healthy subjects, applying 4 different stimulation frequencies. the experiments were subdivided into 3 periods: rest, binary choice task and final rest period. independent of the applied stimulation frequency, an increment of r1 during the task was found, and it was concluded that r1 amplitude reflects the state of arousal of the subject. within each of the 3 periods, r1 amplitudes decreased independently of the applied frequency, while r2 amplitudes decreased d ...199991500
retrolental fibroplasia.retrolental fibroplasia is more accurately referred to as retinopathy of prematurity. host factors most clearly incriminated are the maturity of the infant and the time in oxygen therapy. a continuum of retinopathy ranges from abnormal arborization of terminal retinal vessels to a detached retina incorporated in a cicatrix behind the lens. every high-risk infant should be examined by indirect ophthalmoscopy prior to discharge from the nursery. a thorough knowledge of the natural course of the di ...199991318
therapeutic value of zinc in acne. 2003161550
postoperative urinary retention in patients undergoing anorectal surgery. 20061796976
methemoglobinemia due to occupational exposure to dinitrobenzene--ohio, 1986. 20113131654
[knowledge of poor prognosis and desire for recovery]. 20133638461
[hemorrhagic complications in prostatectomy]. 20144117515
autoerythrocyte sensitization. 20165081179
the vanadium and selected metal contents of some ascidians. 20164822766
lymphocytotoxic antibodies in hydralazine-induced lupus erythematosus. 200192663
assessment of placental function in normal and pathological pregnancies by estimation of plasma oestradiol levels after injection of dehydroepiandrosterone sulphate.a test of placental function was assessed by measurement of plasma oestradiol levels in 32 patients after intravenous injection of 50 mg dehydroepiandrosterone sulphate (dhas). every pregnant patient showed a rise in plasma oestradiol after dhas; two puerperal patients showed no rise. it was not possible to distinguish the variable response in normal pregnancy from that in patients with severe hypertension and proteinuria or with retarded intrauterine fetal growth. the test was of no value in on ...2002126694
verbal imitation in retardates: follow-up. 20154686736
[the state of non-specific immunologic reactivity in healthy preschool and school children]. 20154642505
a review on the epidemiology of nasopharyngeal carcinoma. 20164916218
[adriamycin, cyclophosphamide, vincristine and methotrexate combination chemotherapy of small cell lung cancer].twenty-two patients who had not received previous chemotherapy for small cell lung cancer were treated with a combination of adriamycin (30 mg/m2, i.v., on day 1), cyclophosphamide (500 mg/m2, i.v., on day 1, and 350 mg/m2, i.v., on day 8), vincristine (1 mg/m2, i.v., on day 1) and methotrexate (20 mg/m2, i.v., on days 1 and 8). this chemotherapy regimen was repeated at 3- or 4-week intervals. among 20 evaluable patients, none showed complete response but 14 (70%) showed a partial response, with ...20102838000
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