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fusobacterium necrophorum: a rare cause of meningitis in children.we report a case of non-fatal meningitis secondary to suppurative otitis media in a previously healthy young boy. fusobacterium necrophorum was isolated from blood; spinal fluid was cultured aerobically only but yielded no growth. after treatment with intravenous antibiotics and surgery the patient recovered, with a mild sequela of hypoglossus paresis.200212195886
lemierre's disease caused by co-infection of arcanobacterium haemolyticum and fusobacterium necrophorum: a case report.we report the first case of lemierre's disease caused by a co-infection with a. haemolyticum and f. necrophorum. a characteristic skin rash and predominant growth on multiple blood cultures suggests a causative role for arcanobacterium. failures of penicillin therapy in a. haemolyticum infections should be considered when the initial antibiotic regimen is chosen.200212217717
[a throat infection with rapid deterioration]. 200212362714
[diagnostic image (111). a dyspnoeic man with fever and a sore throat. lemierre's syndrome].an 18-year-old man was admitted because of high fever, a sore throat and dyspnoea. additional investigations revealed tonsillitis, lung abscesses and thrombophlebitis of the internal jugular vein. lemierre's syndrome was diagnosed.200212428462
the evolution of lemierre syndrome: report of 2 cases and review of the literature.lemierre syndrome (postanginal septicemia) is caused by an acute oropharyngeal infection with secondary septic thrombophlebitis of the internal jugular vein and frequent metastatic infections. a high degree of clinical suspicion is necessary for diagnosis. fusobacterium necrophorum is the usual etiologic agent. the disease progresses in several steps. the first stage is the primary infection, which is usually a pharyngitis (87.1% of cases). this is followed by local invasion of the lateral phary ...200212441902
specific detection and differentiation of two subspecies of fusobacterium necrophorum by pcr.the phylogenic relationships of two subspecies of fusobacterium necrophorum were investigated by randomly amplified polymorphism dna-polymerase chain reaction (rapd-pcr). with each of the 12 random primers, the dna fingerprints generated were subjected to cluster analysis for dendrograms. the analysis indicated that twelve strains were organized into two major clusters, and that all strains of each subspecies were confined to one cluster. furthermore, two of the random primers examined each gene ...200312458167
[abdominal pain and necrobacillosis]. 200212481502
liver abscesses due to fusobacterium spp that mimick malignant metastatic liver disease.a 71-year-old man presented with the clinical and radiological features of metastatic liver disease but subsequently was found to have multiple liver abscesses caused by fusobacterium necrophorum. at liver biopsy, pus was aspirated and fusobacterium necrophorum was isolated from the pus. serial blood cultures and urine cultures were sterile and negative for fusobacterium spp. the patient made a complete recovery in response to treatment with penicillin and amoxicillin. this case illustrates the ...200212525925
[the lemierre syndrome--a rare complication of pharyngitis]. 200312607473
lemierre disease in the pediatric intensive care unit, clinical course, and the use of high-frequency oscillatory ventilation.to highlight that cavitating pneumonias may be part of lemierre disease, caused by fusobacterium necrophorum. also to report on the use of high-frequency oscillatory ventilation (hfov) among other strategies, in the treatment of such a cavitating pneumonia.200312656555
pulmonary necrobacillosis in a white-tailed deer. 200312696708
immunogenicity and protective effects of truncated recombinant leukotoxin proteins of fusobacterium necrophorum in mice.fusobacterium necrophorum, a gram-negative, anaerobic and rod-shaped bacterium, is generally an opportunistic pathogen and causes a wide variety of necrotic infections in animals and humans. leukotoxin, a secreted protein, is a major virulence factor. the gene encoding the leukotoxin (lkta) in f. necrophorum has been cloned, sequenced and expressed in escherichia coli. because of low expression levels, problems associated with purifying full-length recombinant protein, and of the physical instab ...200312713895
a case of lemierre's syndrome.lemierre's syndrome is a rare but potentially life-threatening entity that follows an oropharyngeal infection. the syndrome is characterized by an antecedent acute oropharyngeal infection, with secondary suppurative thrombophlebitis of the internal jugular vein and septic emboli. in the pre-antibiotic era, it had a 90% mortality rate. now, with the advent of antibiotics, the prognosis is favorable, but delays in diagnosis may result in increased morbidity and mortality. its incidence appears to ...200312789073
serious consequences of a sore throat.lemierre's syndrome, caused by fusobacterium necrophorum, is a potentially fatal sequelae of a sore throat characterised by septicaemia, internal jugular vein thrombophlebitis and metastatic abscesses. the chief medical officer reported in february 2001 that the incidence is increasing. two cases seen in one year, with different presentations, are reported. the first patient presented with sepsis, jaundice, hepatic abscesses and portal vein/superior mesenteric vein thrombosis, whilst the second ...200312855025
hepatic abscesses caused by fusobacterium necrophorum as part of the lemierre syndrome. 200312869901
lemierre's syndrome: a case report. 200312905453
lemierre syndrome variant: necrobacillosis associated with inferior vena cava thrombosis and pulmonary abscesses after trauma-induced leg abscess.fusobacterium necrophorum, a rarely encountered but potentially lethal bacterial pathogen, is the cause of lemierre syndrome, an oropharyngeal infection complicated by jugular vein thrombophlebitis and metastatic septic embolization. we describe an unusual variant of this disease in a man who developed f necrophorum sepsis (associated with extensive inferior vena cava and common femoral vein thrombosis) and multiple abscesses in the lungs after a trauma-associated abscess of the left lower extre ...200312962171
hyperbaric oxygen (hbo2) in the treatment of lemierre syndrome.in 1936 lemierre described an aggressive neck infection with a high mortality rate. in the original characterization, he describes a pharyngotonsillitis and/or peritonsillar infection followed by unilateral swelling and tenderness along the sternocleidomastoid muscle owing to septic thrombophlebitis of the internal jugular vein. subsequent to invasion and thrombophlebitis of the internal jugular vein, fusobacterium necrophorum septicemia occurs, with rigors, high fever, and septic thromboembolis ...200312964852
bacteriological study of root canals associated with periapical abscesses.the aim of this study was to identify microorganisms from root canals with periapical abscesses and to ascertain the susceptibility of peptostreptococcus prevotii and fusobacterium necrophorum to antimicrobials. study design thirty root canals were microbiologically sampled by using sterile paper points. the concomitant microorganisms were identified through the use of established methods. the susceptibility of p prevotii and f necrophorum to antimicrobials was evaluated by using the e test meth ...200312973290
[a new fusiform bacillus, fusiformis hemolyticus n. sp. responsible for a natural infection of rabbits]. 195213125019
cerebral abscesses in a heifer due to actinomyces necrophorus. 195613278287
[selective medium for the isolation of sphaerophorus necrophorus on the surface]. 196113970253
constancy of deoxyribonucleic acid base composition in the transition of sphaerophorus necrophorus from bacilli to large bodies. 196414240971
[a case of lemierre syndrome].we present a case of lemierre syndrome characterized by thrombophlebitis of the internal jugular vein with multiple metastatic foci after acute otopharyngeal infection in a 30-year-old woman. despite treatment with tonsillectomy leading to a diagnosis of peritonsillar abscess, her condition worsened and she was admitted with high fever. chest radiograph and ct scan of the thorax revealed multiple pulmonary cavities and pleural effusion on the right side. on neck ct, a thrombus was detected in th ...200314531301
lemierre's syndrome. 200314551494
a 12-year-old girl with pharyngitis, meningitis and sinovenous thrombosis. 200314557322
fusobacterial brain abscess: a review of five cases and an analysis of possible pathogenesis.the cases of five patients with fusobacterial brain abscess are presented. the authors discuss their attempt to determine the pathogenesis.200314567605
antibiotic sensitivity and biochemical characterization of fusobacterium spp. and arcanobacterium pyogenes isolated from farmed white-tailed deer (odocoileus virginianus) with necrobacillosis.bacterial cultures from 32 living and dead farmed white-tailed deer (odocoileus virginianus) with necrobacillosis yielded fusobacterium necrophorum from nine individuals, f. varium from six individuals, and arcanobacterium pyogenes from 16 individuals. the isolates were characterized biochemically using automated identification systems. gram-stained smears suggested the presence of fusobacterium spp. in eight cases from which organisms were not cultured. minimum inhibitory concentration determin ...200314582788
[lemierre syndrome: unusual, but still possible].lemierre syndrome is a rare disease, which was life-threatening before the antibiotics era. we report here two cases with favorable outcome. clinical features are stereotypic: tonsillis, cervical pain revealing deep vein thrombosis, and pulmonary septic metastasis. the most frequent causal germ on blood cultures is fusobacterium necrophorum but other anaerobial bacteries can be found. cervical doppler-ultrasonography, and thoracic tomodensitometry are useful. medical treatment is antibiotic ther ...200314593318
increased diagnosis of lemierre syndrome and other fusobacterium necrophorum infections at a children's hospital.to assess the apparent increase in the diagnosis of lemierre syndrome (ls) and other fusobacterium necrophorum infections at a large children's hospital. infections with f necrophorum ranged from peritonsillar abscess to potentially fatal ls. ls is an oropharyngeal infection characterized by septic thrombophlebitis of head and neck veins, complicated by dissemination of septic emboli to pulmonary and systemic sites.200314595080
[mastoiditis caused by fusobacterium necrophorum]. 200314619064
[necrobacillosis and lemierre's syndrome: case report].necrobacillosis (fusobacterium necrophorum septicaemia) and lemierre's syndrome (human necrobacillosis with cephalic origin) are not widely known by clinicians. case report: we report the case of a 5-year-old girl, presenting with a lemierre's syndrome consecutive to otitis media. outcome was favourable under metronidazole and amoxicilline therapy for 6 weeks. conclusion: necrobacillosis remains a severe disease including peripheral abscesses (mainly in the lungs and the liver), often associated ...200314643535
[bacterial meningitis as a complication of fusobacterium necroforum infection in adults].fusobacterium necrophorum, an anaerobic, gram-negative rod, belongs to the physiological flora of the oropharynx. it causes lemierre's syndrome characterized by oropharyngeal infection, septic thrombophlebitis of the neck, in particular of the internal jugular vein, and metastatic abscesses, predominantly in the lungs. rarely, and mainly in children, it causes meningitis. here we report the clinical course of a 25-year-old woman with f. necrophorum meningitis. she presented with incomplete, righ ...200314647913
critical care nurses be aware: lemierre's syndrome is on the rise.lemierre's syndrome (ls) typically occurs in previously healthy young adolescents and young adults who become acutely ill following an attack of pharyngotonsillitis. also known as post anginal sepsis, those afflicted develop pyrexia, rigours and multiple metastatic abscesses that lead to septic thrombophlebitis of the internal jugular vein. in the pre-antibiotic era this particularly virulent syndrome had a mortality rate in excess of 90%, but since the introduction of antibiotics and the widesp ...200314692157
inflammatory polyp in the middle ear with secondary suppurative meningoencephalitis in a cat.a 15-month-old male maine coon cat presented with persistent auricular discharge and progressive head tilt, ataxia, and loss of blink on the right side. using computed tomography a hyperattenuating, contrast-enhancing material within a thickened right tympanic bulla and contrast enhancement of the adjacent cerebellum were identified. marked suppurative inflammation was identified on cerebrospinal fluid analysis with no growth on bacterial culture. ventral bulla osteotomy was performed to remove ...200314703245
relationships among ecology, demography and diseases of european bison (bison bonasus).the bison population in the bialowieza forest in poland has now grown to approximately 300, while the herds in the belarusian part of the forest total about 240 bison. the first signs of a health problem in these herds appeared in 1980, when two cases of balanoposthitis were detected in two bulls (2 and 5 years of age). since 1980 research has been conducted to explain the cause of diseases, particularly balanoposthitis, and to monitor the health of bison in bialowieza forest. a total number of ...200314703870
[fusobacterium necroforum sepsis]. 200314743762
effect of intrauterine administration of oestradiol on postpartum uterine bacterial infection in cattle.after parturition fewer first dominant follicles are selected in the ovary ipsilateral to the previously gravid uterine horn in cattle. however, the presence of a large oestradiol-secreting follicle in the ipsilateral ovary is a predictor of fertility, possibly due to a localised effect of oestradiol which increases the rate of elimination of the ubiquitous uterine bacterial contamination that occurs after calving. the present study tested the hypothesis that oestradiol reduces uterine bacterial ...200414749045
endogenous endophthalmitis secondary to lemierre's syndrome. 200414752504
mastoiditis presenting as an acute abdomen with features of lemierre's syndrome. 200314753585
microbiological examination of infected dental root canals.the aim of this study was to investigate the root canal microbiota of primary and secondary root-infected canals and the association of constituent species with specific endodontic signs and symptoms.200414871344
18-year-old woman with headache and sore throat. 200414959918
complicated otitis media caused by fusobacterium necrophorum.fusobacterium necrophorum is implicated as an aetiological agent in a variety of necrotic diseases, such as lemièrre's syndrome (ls) in humans. ls was initially described as septic thrombophlebitis of the internal jugular vein secondary to an acute oropharyngeal infection. other primary sources of infection include parotitis, otitis media, sinusitis, odontogenic infection and mastoiditis. in the pre-antibiotic era ls carried a high mortality. this has been reduced as a result of the widespread u ...200414979974
internal jugular vein thrombophlebitis secondary to oropharyngeal infection with fusobacterium necrophorum. 200414984536
necrotizing stomatitis associated with fusobacterium necrophorum in two goats.necrotizing stomatitis associated with fusobacterium necrophorum in two goats is described. arcanobacterium pyrogenes was the dominant component of the microbial flora cultured under aerobic condition. treatment with penicillin, at a dose of 50 000 iu/kg for 6 days was used successfully in the cure of the disease.200414995978
experimental swine dysentery: comparison between infection models.the aim of the present study was to develop a reproducible porcine infection model with brachyspira hyodysenteriae. the influence of different factors was evaluated, namely, age, a diet containing large quantities of soybean meal, housing and administration of cortisol or antacids. furthermore, the synergistic effect of additional bacteria (escherichia coli o141, bacteroides vulgatus or a mixture of bacteroides fragilis, a field isolate of bacteroides and fusobacterium necrophorum) was studied. ...200415017282
geographical differences in bacteria detected in endodontic infections using polymerase chain reaction.the polymerase chain reaction (pcr) is an innovative nucleic acid-based assay that has the highest sensitivity of any microbiological technique for the detection of bacteria. the purpose of this study was to use pcr to detect the presence of specific species of bacteria in samples collected from two geographical locations. microbial samples from abscesses of endodontic origin were collected from patients in portland, oregon, and rio de janeiro, brazil. pcrs with species-specific oligonucleotide ...200415055430
orbital abscess caused by fusobacterium necrophorum.we report the case of previously healthy boy with orbital abscess secondary to sinusitis. fusobacterium necrophorum and streptococcus anginosus was cultured both from the maxillary sinus and the orbital abscess. after surgical drainage and intravenous antibiotic treatment the boy recovered without complications.200415081233
images in clinical medicine. lemierre's syndrome. 200415084710
cerebral infarct and meningitis secondary to lemierre's syndrome.the case is reported of a young man with fusobacterium necrophorum septicemia who developed cavernous sinus thrombosis, meningitis, carotid artery stenosis and stroke. this article presents the only reported case of arterial stroke in lemierre's syndrome. clinical presentation, diagnostic difficulty and treatment are discussed.200415087108
otogenic fusobacterium meningitis, sepsis, and mastoiditis in an adolescent.fusobacterium necrophorum is a strict anaerobic organism responsible for a number of clinical syndromes known as necrobacillosis. although meningeal infections with anaerobes are rare, delayed diagnosis and treatment can be potentially fatal. we report a unique case of fusobacterium meningitis, mastoiditis, and sepsis in a previously healthy adolescent. diagnosis and management of this condition are discussed in the context of a literature review.200415108842
lemierre's syndrome: more than a historical curiosa.lemierre's syndrome is a severe illness caused by the anaerobic bacterium, fusobacterium necrophorum which typically occurs in healthy teenagers and young adults. the infection originates in the throat and spreads via a septic thrombophlebitis of the tonsillar vein and internal jugular vein. the ensuing bacteraemia is complicated by septic emboli to a range of sites such as lung, joints, and bones. although rare, there is evidence of a resurgence in the condition in recent years, possibly associ ...200415192164
itih4 (inter-alpha-trypsin inhibitor heavy chain 4) is a new acute-phase protein isolated from cattle during experimental infection.we have isolated from calf serum a protein with an apparent m(r) of 120,000. the protein was detected by using antibodies against major acute-phase protein in pigs with acute inflammation. the amino acid sequence of an internal fragment revealed that this protein is the bovine counterpart of itih4, the heavy chain 4 of the inter-alpha-trypsin inhibitor family. the response of this protein in the sera was determined for animals during experimental bacterial and viral infections. in the bacterial ...200415213118
pathologic quiz case: an 18-year-old man presenting with sepsis following a recent pharyngeal infection. lemierre syndrome. 200415214813
a life-threatening sore throat. 200415234866
septic arthritis of the knee due to fusobacterium necrophorum.gram-negative, anaerobic bacilli are unusual organisms to be isolated in cases of acute septic arthritis. we report the isolation of fusobacterium necrophorum from joint aspirate in a case of acute septic arthritis, which presented 3 weeks after the drainage of a dental abscess.200415243120
lemierre's syndrome: how a sore throat can end in disaster.lemierre's syndrome is characterised by a history of recent oropharyngeal infection, clinical or radiological evidence of internal jugular vein thrombophlebitis and isolation of an anaerobic pathogen. we present a case report and review the literature.200415249813
meningitis due to fusobacterium necrophorum in an adult.fusobacterium necrophorum may cause a number of clinical syndromes, collectively known as necrobacillosis. meningitis is a significant cause of mortality, rarely reported in the adult population.200415296514
chron's disease, rare association with selective iga immunodeficiency, and development of life-threatening bacterial infections.life-threatening necrotizing fasciitis and relapsing lemierre syndrome associated with fusobacterium necrophorum septicaemia occurred in young adults with a moderate chron's disease and a missed profound iga deficiency. this unexpected association of a chronic bowel inflammatory syndrome with prominent iga abnormalities and severe bacterial infection deserves careful attention by physicians faced with young patients with chron's disease.200415307592
fibrinonecrotic rhinitis caused by a concurrent infection of fusobacterium necrophorum and arcanobacterium pyogenes in a cow.an 8 year-old cow showing severe dyspnea and nasal mucosal necrosis immediately after parturition was subjected to pathological examination. the principal lesions were fibrinonecrotic rhinitis, necrotic bronchopneumonia and renal infarction. fusobacterium necrophorum biotype a and arcanobacterium pyogenes antigens were detected in the nasal and pulmonary lesions. these results suggest that the lesions were caused by a concurrent infection of the detected bacteria and that the pulmonary lesions w ...200415353853
real-time pcr investigation into the importance of fusobacterium necrophorum as a cause of acute pharyngitis in general practice.fusobacterium necrophorum is recognized as the cause of a severe life-threatening illness characterized by bacteraemia with metastatic abscesses following an acute sore throat (lemierre's disease). however, the importance of f. necrophorum as a cause of simple sore throat in the community is unknown. using quantitative real-time pcr with primers targeting the rpob gene, 100 routine throat swabs collected from patients presenting to general practitioners with pharyngitis were analysed for the pre ...200415358827
use of an oligonucleotide array for laboratory diagnosis of bacteria responsible for acute upper respiratory infections.we developed a diagnostic array of oligonucleotide probes targeting species-specific variable regions of the genes encoding topoisomerases gyrb and pare of respiratory bacterial pathogens. suitable broad-range primer sequences were designed based on alignment of gyrb/pare sequences from nine different bacterial species. these species included corynebacterium diphtheriae, fusobacterium necrophorum, haemophilus influenzae, legionella pneumophila, moraxella catarrhalis, mycoplasma pneumoniae, staph ...200415365022
segmental ileitis; possibly caused by bacterium necrophorum. 195015402802
detection of pathogens from periodontal lesions.to comparatively detect a. actinomycetemcomitans and f. nucleatum from periodontal and healthy sites.200415499445
minimum inhibitory concentrations of some antimicrobial drugs against bacteria causing uterine infections in cattle.the minimum inhibitory concentrations (mics) of oxytetracycline, cephapirin, cephapirin/mecillinam, cefquinome, ceftiofur and enrofloxacin, candidate antibiotics for the principal bacteria associated with uterine infections: escherichia coli, arcanobacterium pyogenes and the anaerobic bacteria fusobacterium necrophorum and prevotella melaninogenicus, were determined by the agar dilution method. the bacteria were isolated from animals with clinical metritis and/or endometritis. for e coli, cefqui ...200415499809
phylogenetic analysis of fusobacterium necrophorum, fusobacterium varium and fusobacterium nucleatum based on gyrb gene sequences.the nucleotide sequences of the dna gyrase b subunit gene (gyrb) of fusobacterium necrophorum subsp. necrophorum, f. necrophorum subsp. funduliforme and f. varium were determined and analyzed together with those of f. nucleatum subsp. nucleatum and f. nucleatum subsp. vincentii. on the phylogenetic tree constructed, the strains of each fusobacterial species formed distinct clusters with deep sublines. the degree of sequence similarity within each cluster was 93.2% or more, whereas similarities b ...200415528856
a retrospective study of mortality in pennsylvania captive white-tailed deer (odocoileus virginianus): 20000--2003.the postmortem records of 160 white-tailed deer (odocoileus virginianus) submitted for necropsy examination from 59 separate pennsylvania captive deer farms over a 3.5-year period were reviewed to determine the primary cause of death of each animal. the most common causes of death were bronchopneumonia (39 cases), enterocolitis (30 cases), malnutrition (13 cases), and trauma (11 cases). other causes of mortality included severe gastrointestinal parasitism (6 cases), cellulitis with septicemia (5 ...200415586566
clinical evaluation of postpartum vaginal mucus reflects uterine bacterial infection and the immune response in cattle.bacteria contaminate the uterus of most dairy cattle after parturition and endometritis causes infertility. an endometritis score can be ascribed based on the vaginal mucus character and odour but it is not clear if the clinical score reflects the number of uterine bacteria or the inflammatory response. the present study tested the hypothesis that clinical evaluation of endometritis reflects the number of bacteria present in the uterus, and the acute phase protein response. swabs (n = 328) were ...200515589277
lemierre's syndrome: three cases and a review.postanginal sepsis, also called lemierre's syndrome, is a rare but acute medical condition complicating oropharyngeal infection. the pathogenesis consists of the development of internal jugular vein septic thrombophlebitis leading to metastatic infections in the lung and other sites. the causative microorganism is most often fusobacterium necrophorum. we present three patients with lemierre's syndrome who presented to the leiden university medical center and give a review of the literature.200415599753
comparative study of three surgical treatments for two forms of the clinical presentation of bovine pododermatitis.in this study, 1013 animals showing signs of clinical pododermatitis were examined and divided into five unevenly numbered groups. affected animals in groups i and ii showed only signs of vegetative interdigital pododermatitis. the lesions were surgically removed and either protected with bandages (in group i) or cauterized with incandescent iron (group ii). the animals in groups iii, iv, and v, showed signs of necrotic pododermatitis. these were treated with different protocols after the necrot ...200415604479
a case of the otogenic variant of lemierre's syndrome with atypical sequelae and a review of pediatric literature.we report a case of an 8-year-old girl who presented with the clinical picture of lemierre's syndrome (ls) secondary to bilateral mastoiditis. she developed unilateral sensorineural hearing loss (snhl) along with internal jugular vein (ijv) thrombosis, septic arthritis of her ankle and cervical fasciitis. combined antimicrobial, anticoagulant and surgical treatment helped reverse all the effects of the sequelae, including nearly all the hearing loss. this is a unique case of this uncommon varian ...200515627459
fusobacterium nucleatum increases collagenase 3 production and migration of epithelial cells.fusobacterium nucleatum is closely associated with human periodontal diseases and may also be a causative agent in other infections, such as pericarditis, septic arthritis, and abscesses of tonsils and liver. initiation and outcome of infective diseases depend critically on the host cell signaling system altered by the microbe. production of proteinases by infected cells is an important factor in pericellular tissue destruction and cell migration. we studied binding of f. nucleatum to human epit ...200515664960
fusobacterium necrophorum mediastinal abscess presenting as an anterior chest wall mass in a child: a case report. 200515678234
current approaches to the management of ovine footrot.ovine footrot remains the most important cause of lameness in sheep flocks in the uk, despite the existence of proven methods for the control of the disease. recent research suggests that sheep farmers may be unaware of these methods and may allocate greater resources to treatment of footrot rather than to its prevention. foot paring, topical treatments, vaccination and parenteral antibiotic therapy all have a role in treating sheep with advanced footrot infections, but prevention of severe infe ...200515683762
clinicopathological conference: lemierre's syndrome. 200515692137
lemierre's syndrome. 200415724731
dermotoxic activity of a collagenolytic cell wall component from fusobacterium necrophorum subsp. necrophorum. 200515727927
influence of flavomycin on ruminal fermentation and microbial populations in sheep.flavomycin is a phosphoglycolipid antibiotic that promotes growth in ruminants. the aim of this study was to characterize the effects of flavomycin on ruminal micro-organisms and their metabolic consequences. in sheep receiving a mixed grass hay/concentrate diet, inclusion of 20 mg flavomycin day(-1) decreased ruminal ammonia and total volatile fatty acid concentrations (p<0.001), but the acetate : propionate ratio was unchanged. ruminal ph tended to be lower with flavomycin, and ammonia-product ...200515758218
lemierre syndrome.lemierre syndrome is a disease that presents with oropharyngeal infection, sepsis, internal jugular vein thrombosis, and septic emboli with the gram-negative organism fusobacterium necrophorum cultured as the etiologic agent. clindamycin, metronidazole and ampicillin-sulbactam are effective antibiotic treatments, although the length of treatment has not been firmly established. the syndrome is seen less frequently in the current age of antibiotics. it is important, however, that physicians be aw ...200515769572
molecular diagnosis of fusobacterium necrophorum infection (lemierre's syndrome).presented here is the case of a 27-year-old male with atypical features of lemierre's syndrome in which a definitive diagnosis was achieved using molecular methods. while routine investigations, including bacterial cultures, were unhelpful, two real-time pcr assays demonstrated fusobacterium necrophorum-specific dna in aspirates from brain and renal abscesses. this is the first report demonstrating that a laboratory diagnosis can be made using molecular methods in suspected cases of lemierre's s ...200515776252
fusobacterium necrophorum-induced sepsis: an unusual case of lemierre's syndrome.classical lemierre's syndrome is characterized by severe sepsis with metastatic abscess formation in young, previously fit people from a primary head or neck focus. the causative organisms are the anaerobic fusobacteria, most commonly fusobacterium necrophorum. we describe the evaluation, therapeutic interventions and management of a patient with lemierre's syndrome who presented in septic shock with multiple organ dysfunction. the patient required immediate interventions including endotracheal ...200515777309
miriam hospital and rhode island hospital morbidity and mortality conferences, case of lemierre syndrome. 200515816248
respiratory failure and hypercoagulability in a toddler with lemierre's syndrome.a 3.5-year-old healthy boy with 4 days of fever was referred to the emergency department for respiratory distress. the physical examination was remarkable for stupor, tachycardia, tachypnea, and dyspnea. initial blood tests showed pancytopenia. he rapidly developed torticollis. computerized tomography of the neck revealed a thrombus in the internal jugular vein. a presumptive diagnosis of lemierre's syndrome was made and he was started on antibiotics and anticoagulation. he subsequently develope ...200515833890
lemierre's syndrome: the controversy of anticoagulation. 200515867055
lemierre's syndrome: a forgotten complication of oropharyngeal infection.lemierre's syndrome (postanginal sepsis) usually complicates an oropharyngeal infection as septicemia, septic thrombophlebitis of the internal jugular vein, and metastatic lesions, most frequently in the lungs. fusobacterium necrophorum is the usual etiologic agent. lemierre's syndrome is not widely known by clinicians. this study aims at creating awareness amongst the clinicians of existence of this potentially fatal but curable clinical entity.200515929523
prevalence of fusobacterium necrophorum and other upper respiratory tract pathogens isolated from throat swabs.fusobacterium necrophorum, an anaerobic, gram-negative rod, has been identified recently as a significant cause of persistent sore throat syndrome (psts). this disease is characterised by chronic, recurrent or persistent sore throat, which is believed to respond poorly to penicillin in vivo. the aim of this study is to examine the prevalence of f. necrophorum in all throat swabs received in our diagnostic microbiology department and to compare the results with those for other recognised respirat ...200515997879
cerebral infarctions and brain abscess due to lemierre syndrome.lemierre syndrome is characterized by anaerobic bacterial infection in the head and neck, causing thrombophlebitis of the jugular vein and septic metastasis to various distant organs, most often the lungs. here we describe previously unreported clinical features of cerebral infarctions and brain abscess due to metastatic septic embolism of this uncommon but lethal syndrome, and the successful course of treatment with ampicillin, cefotaxime and metronidazole.200516020900
lemierre syndrome with jugular thrombophlebitis and cavitary pneumonia. 200516038226
vertebral osteomyelitis due to fusobacterium species: report of three cases and review of the literature.we describe three cases of fusobacterium spp. diskitis and review with attention to risk factors, clinical features, diagnosis, treatment and outcome. in most of the reported cases, a ear-nose-throat infection was found. clinical manifestations were similar to those of classic bacterial vertebral osteomyelitis. clindamycin is the most appropriate antibiotic. the outcome seems to be very good without relapse with appropriate treatment compared to pyogenic vertebral osteomyelitis.200516038751
fusobacterium necrophorum as the cause of recurrent sore throat: comparison of isolates from persistent sore throat syndrome and lemierre's disease.fusobacterium necrophorum is a well established cause of lemierre's disease (ld); a syndrome characterised by severe sore throat, septicaemia, multiple abscesses and jugular vein thrombosis. there is no published data concerning the role of f. necrophorum in recurrent sore throats. as the result of an index case of persistent sore throat attributable to this organism being diagnosed in our laboratory, a subsequent case controlled study (not yet published) isolated f. necrophorum from 21% (p=0.00 ...200416051369
[clinical case #3. venous thrombosis of the lateral sinus]. 200516114213
[one curettage, two celioscopies, two or three laparotomies...]. 200516129171
[a fever without strong teeth!...]. 200516129174
lemierre's and lemierre's-like syndromes in children: survival and thromboembolic outcomes.lemierre's syndrome, or jugular vein thrombosis (jvt) associated with anaerobic infection of the head and neck and frequently complicated by septic pulmonary embolism (pe), has historically been described as a disease of young adults. in recent years, an increasing number of case reports of childhood lemierre's syndrome have been published, focusing mostly on the clinical and laboratory findings at disease presentation and the outcomes of infection. given the potentially life-threatening thrombo ...200516147971
septic arthritis secondary to fusobacterium necrophorum in a 4-year-old girl: case report and review of the literature.we report an unusual case of septic arthritis in a 4-year-old child caused by fusobacterium necrophorum. in spite of aggressive parenteral antibiotic therapy with ampicillin-sulbactam after surgical drainage, disease recurred, requiring additional arthrotomies. the infection was eventually eradicated with parenteral meropenem and clindamycin, and additional surgical drainage.200516148860
fusobacterium necrophorum infection associated with portal vein thrombosis.this report describes a patient without obvious upper respiratory tract or gastrointestinal infection who developed portal vein thrombosis secondary to fusobacterium necrophorum septicaemia. the patient responded well to systemic antibiotic therapy. the implications of f. necrophorum infection caudal to the head are discussed.200516157556
lemierre syndrome: presentation of three cases. 200516181600
"my back is killing me".this is a case of a rare cause of back pain that presented to several clinicians before the diagnosis became obvious and the correct management was initiated. lemierre's syndrome was confirmed at post mortem examination. we conclude that thoracic back pain should not be assumed to have a simple mechanical cause and that efforts should be made to discover the underlying aetiology.200516244352
[the lemierre syndrome: a complicated oropharyngeal infection].the lemierre syndrome or 'necrobacillosis' is a post angina sepsis caused by an acute oropharyngeal infection with a secondary thrombophlebitis of the internal jugular vein. there are often septic emboli in the lungs, although intestinal organs can also be affected. this syndrome is caused by the strictly anaerobic gram-negative pathogen fusobacterium necrophorum, sometimes in combination with other pathogens. the patient typically presents with high fever, pain in the neck, malaise and dyspnoea ...200516279397
'papillomatization' and 'malignant transformation' of an abscess cavity in a 25-year old man with recurrent respiratory papillomatosis who may have had lemierre syndrome.we report here an unusual case of a 25-year old male with juvenile onset recurrent respiratory papillomatosis who developed an infestation of papillomata 'papillomatization' of an old abscess cavity that, when removed, was coincidently found to contain a 2 cm well differentiated squamous cell carcinoma. the abscess cavity had been caused by a previous fusobaterium necrophorum infection that probably developed as a result of septic emboli from his internal jugular veins. this once common but now ...200416281650
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