an unusual paracaecal abscess associated with fusobacterium necrophorum in a horse. 19989830563
preterm labor and bacterial intraamniotic infection: arachidonic acid liberation by phospholipase a2 of fusobacterium nucleatum.the studies presented in this report were undertaken to evaluate whether fusobacterium nucleatum, a common anaerobic isolate in intrauterine infection, stimulates arachidonic acid metabolism, a rate-limiting step for prostaglandin synthesis, in the human uterine endometrium.19989855600
[clinical evaluation of lung abscess diagnosed by transtracheal aspiration].we have diagnosed lung abscess according to findings of infiltration with cavity formation on chest x-ray and/or ct-scan and pathogens isolated from transtracheal aspirates. we evaluated the clinical features of 20 patients with lung abscess (18 males and 2 females, mean age; 54.3 years). diabetus mellitus and periodontal diseases were prominent underlying diseases in patients with lung abscess. cough was complained in 13 patients, chest or back pain in 9, purulent sputum in 8 and hemosputum in ...19989884505
unexpected cross-reaction with fusobacterium necrophorum in a pcr for detection of mycoplasmas.cross-reactions with fusobacterium necrophorum were found in a pcr designed for detection of a wide range of mycoplasma species. twenty-five strains of fusobacterium were examined; all 14 f. necrophorum strains reacted positively, whereas all 7 fusobacterium nucleatum strains reacted negatively. two strains that were not f. necrophorum yielded variable results.19999986867
isolation of fusobacterium necrophorum from cancrum oris (noma).a study of the predominant microflora in active sites of noma (cancrum oris) lesions was carried out in eight noma patients 3-15 years of age in sokoto state in northwestern nigeria. paper point sampling and conventional anaerobic microbiologic techniques were used. fusobacterium necrophorum was recovered from 87.5% of the noma lesions. oral microorganisms included prevotella intermedia, alpha-hemolytic streptococci, and actinomyces spp. which were isolated from 75.0%, 50.0%, and 37.5% of the pa ...19999988340
pathogenesis of cancrum oris (noma): confounding interactions of malnutrition with infection.this study showed that impoverished nigerian children at risk for cancrum oris (noma) had significantly reduced plasma concentrations of zinc (< 10.8 micromol/l), retinol (< 1.05 micromol/l), ascorbate (< 11 micromol/l), and the essential amino acids, with prominently increased plasma and saliva levels of free cortisol, compared with their healthy counterparts. the nutrient deficiencies, in concert with previously reported widespread viral infections (measles, herpesviruses) in the children, wou ...199910072140
devastating complications of acute pediatric bacterial sinusitis. 199910187964
lateral dural sinus thrombosis in present etiology, diagnosis, and treatment of dural sinus thrombosis (dst) in children. to discuss the diagnostic role of contrast-enhanced computed tomography (cect) and to evaluate the controversial treatment modalities of anticoagulation, surgical drainage of the infected sinus, and ligation of the internal jugular vein (ijv).199910201757
an unusual cause of an 'acute abdomen'. 199810320893
lemierre syndrome and acute mastoiditis.lemierre syndrome seldom follows an episode of pharyngotonsillitis. characteristically, it is comprised of septic thrombosis of the internal jugular vein and bacteremia, leading to lung emboli and metastatic abscess formation. we describe lemierre syndrome that complicates an acute mastoiditis, with considerations regarding its pathogenesis and management. despite its sporadic occurrence, awareness of lemierre syndrome is important, since early recognition reduces both the morbidity and mortalit ...199910326820
bacterial flora of liver abscesses in feedlot cattle fed tylosin or no tylosin.bacterial flora of liver abscesses from cattle fed tylosin or no tylosin and susceptibilities of the predominant bacterial isolates to tylosin and other antimicrobial compounds were determined. abscessed livers were collected at slaughter from cattle originating from feedlots that had fed tylosin (n = 36) or no tylosin (n = 41) for at least 2 yr, and segments of livers with one or two intact abscesses were transported to the laboratory. abscesses were cultured for anaerobic and facultative bacte ...199910328365
capnocytophaga canimorsus sepsis. 199910328724
'deep throat' cellulitis. 199910342660
location of haemagglutinin in bacterial cells of fusobacterium necrophorum subsp. necrophorum.the location of haemagglutinin (ha) of fusobacterium necrophorum subsp. necrophorum vpi 2891 strain was investigated by immunofluorescence, confocal laser scan microscopy and immunoelectron microscopy. the immunofluorescence study demonstrated the fluorescence specific for the ha on the bacterial cells and confocal laser scan microscopy indicated similar fluorescence around the cross section of the bacterial cell. the immunoelectron microscopic study also revealed that the protein a-gold conjuga ...199810347900
lemierre's syndrome.postanginal sepsis, or lemierre's syndrome, is rare but with life-threatening potential involving mainly infants and adolescents. the morbidity or mortality is caused mainly by lack of knowledge of the syndrome. the 18-year-old boy described here developed a jugular thrombosis 7 days after an angina. fusobacterium necrophorum was isolated from the culture of the excised jugular vein. secondary embolism involved the lungs, associated with an iliac osteomyelitis and sacroiliitis. computed tomograp ...199910354883
an old disease makes a comeback.a 15-year-old african-american female was hospitalized following 7 days of fever, pharyngitis, and neck pain. physical exam revealed enlarged tonsils. a rapid group a streptococcus antigen test was negative, and the throat culture showed no streptococci. the blood culture grew fusobacterium necrophorum. lumbar puncture results were negative. chest ct scan showed apical cavitary lesions of the lungs. doppler and ct scan of the neck showed narrowing of the right internal jugular vein, compatible w ...199610359993
[septic thrombophlebitis of the internal jugular vein due to fusobacterium necrophorum (lemierre's syndrome): case report and review of literature].lemierre's syndrome is an uncommon clinical entity. it is characterized by oropharyngeal infection followed by septic thrombophlebitis of the jugular vein with embolization to the lungs and other organs. it is usually due to fusobacterium necrophorum. although lemierre's syndrome is rare, it is potentially fatal. it is important for clinicians to recognize and treat it appropriately. with prompt recognition, abscess drainage with possible ligation of the internal jugular vein and appropriate ant ...199810361747
bovine polymorphonuclear neutrophil-mediated phagocytosis and an immunoglobulin g2 protease produced by porphyromonas levii.acute interdigital phlegmon (aip) is a commonly occurring anaerobic bacterial infection in cattle. this study examined in vitro the interaction of bovine polymorphonuclear granulocytic neutrophils (pmn) from blood with bacterial species involved in aip. polymorphonuclear neutrophils were purified from whole bovine blood, exposed to one of the three putative etiologic agents of aip and comparatively assessed for phagocytosis using light microscopy. fusobacterium necrophorum and prevotella interme ...199910369568
lemierre's syndrome (necrobacillosis).lemierre's syndrome or postanginal septicaemia (necrobacillosis) is caused by an acute oropharyngeal infection with secondary septic thrombophlebitis of the internal jugular vein and frequent metastatic infections. fusobacterium necrophorum is the most common pathogen isolated from the patients. the interval between the oropharyngeal infection and the onset of the septicaemia is usually short. the most common sites of septic embolisms are the lungs and joints, and other locations can be affected ...199910448489
effect of virginiamycin on ruminal fermentation in cattle during adaptation to a high concentrate diet and during an induced acidosis.the objective of exp. 1 was to compare the effects of virginiamycin (vm; 0, 175, or 250 mg x animal(-1) x d(-1)) and monensin/tylosin (mt; 250/ 90 mg x animal(-1) x d(-1)) on ruminal fermentation products and microbial populations in cattle during adaptation to an all-concentrate diet. four ruminally cannulated, holstein steers were used in a 4x4 williams square design with 21-d periods. steers were stepped up to an all-concentrate diet fed at 2.5% of bw once daily. ruminal ph, protozoal counts, ...199910462007
in vitro activity of gemifloxacin (sb 265805) against anaerobes.gemifloxacin mesylate (sb 265805), a new fluoronaphthyridone, was tested against 359 recent clinical anaerobic isolates by the national committee for clinical laboratory standards reference agar dilution method with supplemented brucella blood agar and an inoculum of 10(5) cfu/spot. comparative antimicrobials tested included trovafloxacin, levofloxacin, grepafloxacin, sparfloxacin, sitafloxacin (du-6859a), penicillin g, amoxicillin clavulanate, imipenem, cefoxitin, clindamycin, and metronidazole ...199910471570
effects of tylosin on concentrations of fusobacterium necrophorum and fermentation products in the rumen of cattle fed a high-concentrate determine effects of tylosin on ruminal concentrations of fusobacterium necrophorum and fermentation products in cattle during rapid adaptation to a high-concentrate diet.199910490072
adherence of fusobacterium necrophorum subspecies necrophorum to different animal cells.the adherence of fusobacterium necrophorum subsp. necrophorum to the surfaces of animal cells was studied in order to elucidate the differences between the bacterial appearance in clinical specimens from various animals. the bacterial cells had a strong affinity for murine and rabbit cheek cell surfaces. the bacterium showed a moderate affinity for goat cells, whereas it adhered not so well to canine, feline, human or porcine cells. treatment of the bacterial cells with haemagglutinin antiserum ...199910510867
fusobacterium necrophorum haemolysin stimulates motility of ileal longitudinal smooth muscle of the guinea-pig.fusobacterium necrophorum haemolysin (0.5-3.1 mg protein/ml) dose-dependently induced contractions of the isolated ileal longitudinal smooth muscle of the guinea-pig. the haemolysin (3.1 mg protein/ml) -induced maximum contraction of 75% of the response to 60 mm k+ declined within 17 min and the muscles then demonstrated rhythmic contractions. tetrodotoxin (3.1 x 10(-6) m) had no effect on the contraction due to the haemolysin. after incubation in ca(2+)-free medium, the ileal response to the ha ...199910520727
noma (cancrum oris): questions and answers.noma (cancrum oris) is an infectious disease which destroys the oro-facial tissues and other neighboring structures in its fulminating course. it affects predominantly children aged 2-16 years in sub-saharan africa where the estimated frequency in some communities may vary from one to seven cases per 1000 children. the key risk factors are poverty, malnutrition, poor oral hygiene, deplorable environmental sanitation, close residential proximity to livestock, and infectious diseases, particularly ...199910522212
microbiological understandings and mysteries of noma (cancrum oris).the microbiologic history of noma was reviewed. studies have associated the disease process with large numbers of fusiform bacilli and spirochetal organisms. in order to study the microbiology of the staging and infection periods of noma 62 nigerian children, aged 3-14 years, 22 children had acute necrotizing ulcerative gingivitis (anug) and were also malnourished, 20 exhibited no acute necrotizing ulcerative gingivitis but were malnourished and 20 were free of acute necrotizing ulcerative gingi ...199910522213
activities of gemifloxacin (sb 265805, lb20304) compared to those of other oral antimicrobial agents against unusual anaerobes.the activities of gemifloxacin (sb 265805, lb20304) and comparator agents were determined by an agar dilution method against 419 clinical strains of less-commonly identified species of anaerobes. gemifloxacin was generally more active than trovafloxacin against gram-positive strains by one to two dilutions. peptostreptococci (peptostreptococcus asaccharolyticus, peptostreptococcus magnus, peptostreptococcus micros, and peptostreptococcus prevotii) and porphyromonas spp. (porphyromonas asaccharol ...199910543754
[a febrile syndrome with multiple pulmonary nodules]. 199910568159
ovine footrot. 199910606025
a young man with a characteristic syndrome. 200010622788
actin degradation concomitant with fusobacterium necrophorum subsp. necrophorum adhesion to bovine portal cells.the effects of fusobacterium necrophorum subsp. necrophorum on cellular actin were investigated using tissue-cultured bovine portal cells. fluorescence studies revealed the appearance of intense fluorescent spots on the cellular actin and the spots increased in a time dependent manner. sodium dodecyl sulphate polyacrylamide gel electrophoresis profiles manifested partial or complete degradation of actin preparation after treatment with the bacterial cells. these findings suggest that the bacteri ...199910624007
chemical composition of endotoxins produced by fusobacterium necrophorum subsp. necrophorum and f. necrophorum subsp. funduliforme.the endotoxins from two recently-classified subspecies of fusobacterium, namely f. necrophorum subsp. necrophorum and f. necrophorum subsp. funduliforme, were compared. chemical analysis of the isolated endotoxins revealed that they were clearly different. distinct levels of polysaccharides were demonstrated. the endotoxins isolated were devoid of heptose and 3-deoxy-d-manno-octulosonate (kdo). the endotoxins of f. n. necrophorum and f. n. funduliforme contained lipid a in a ratio of 4:1 which m ...199910643665
[fusobacterium necrophorum in acute otitis media]. 199910650656
isolation of fusobacteria from the oral cavities of malnourished nigerian children living in agricultural and herding villages.a previous study demonstrated the presence and possible involvement of fusobacterium necrophorum in the pathogenesis of noma lesions of children living in agricultural and herding villages in northwestern nigeria. in order to determine if f. necrophorum was part of the oral flora of malnourished children with no noma lesions, a study of the fusobacteria present in the oral cavities of 30 children, 2-6 years of age in sokoto state, was undertaken. swabs taken of the oral cavity were cultured on s ...200010702787
bilateral gluteal abscesses as a unique manifestation of fusobacterium septicaemia. 200010725087
anaerobic bacteremia in a neutropenic patient with oral increasing number of anaerobic bloodstream infections in neutropenic cancer patients have been reported in the last decade. the type of anaerobes isolated from most of these patients suggests an oral source of infection. we describe a case of anaerobic bacteremia in a neutropenic patient with oral mucositis that highlights the importance of considering these organisms when selecting empiric prophylactic or therapeutic antimicrobial regimens, especially in the setting of periodontal disease or ...200010746831
effects of fusobacterium necrophorum subspecies necrophorum on extracellular matrix of tissue-cultured bovine kidney cells.the effects of fusobacterium necrophorum subsp. necrophorum on the extracellular matrix were investigated. the toxic preparation from the culture induced reduction in the number of tissue-cultured bovine kidney cells. the exposed cells often manifested partial loss of cytoplasm and were morphologically irregular. scanning electron microscopy demonstrated partial loss of the microvilli on the exposed cells and roughness of the cell surfaces. finally, sodium dodecyl sulphate polyacrylamide gel ele ...200010756519
anaerobic septicaemia by fusobacterium necrophorum: lemierre's syndrome.lemierre's syndrome is characterized by acute pharyngotonsillitis with secondary thrombophlebitis of the internal jugular vein which is complicated by multiple metastatic foci of infections. this syndrome is caused by fusobacterium necrophorum in healthy young persons and is extremely rare in occurrence. a pre-school child with lemierre's syndrome is reported. the diagnostic and therapeutic aspects are emphasized in order to sensitize physicians to this uncommon condition.199810772002
adherence of fusobacterium necrophorum subsp. necrophorum to ruminal cells derived from bovine rumenitis.fusobacterium necrophorum subsp. necrophorum strain vpi 2891 was shown to adhere to the surfaces of ruminal cells derived from bovine rumenitis. the strain also attached to bovine type 1 collagen. treatment of the bacterium with antiserum to bacterial cells reduced attachment. the bacterial attachment was also markedly reduced when the ruminal cells had been pretreated with anticollagen serum. fluorescence specific for the collagen was demonstrated on the surface of bovine tissue affected with r ...200010792652
endotoxin-triggered haematological interactions in fusobacterium necrophorum infections.the haematological mechanisms in the course of liver abscess formation were evaluated. they were examined by employing viable cells of fusobacterium necrophorum subsp. necrophorum and fusobacterium necrophorum subsp. funduliforme in comparison with their endotoxins. whole cell infection with f.n. necrophorum led to neutrophilia and to a concomitant monocytosis in parallel with those responses induced by the in vivo injection of its endotoxin. viable infection with f.n. funduliforme was character ...200010817519
review of the in vitro activity of gemifloxacin against gram-positive and gram-negative anaerobic pathogens.published reports on the in vitro activity of gemifloxacin mesylate (sb 265805), a new fluoronaphthyridone, against anaerobic pathogens are reviewed here. the studies used a variety of media, inocula and antimicrobial agents. using a proposed breakpoint of 0.5 mg/l, these studies showed that gemifloxacin had generally higher potency against gram-positive anaerobes (clostridium perfringens, all peptostreptococcus spp.) and fusobacteria (fusobacterium nucleatum, fusobacterium necrophorum) and mode ...200010824034
septic portal vein thrombosis due to fusobacterium necrophorum. 199910868544
[an uncommon cold: lemierre syndrome]. 200010901790
a medical clerk with chills, fever, and neck mass. 200010955032
fusobacterium osteomyelitis of the pubic symphysis in a healthy soccer player. 200010955353
lemierre syndrome: magnetic resonance imaging and computed tomographic appearance.lemierre syndrome consists of septic thrombophlebitis of the internal jugular vein secondary to oropharyngeal infection, usually with fusobacterium necrophorum. septic metastatic emboli and distant infection are characteristic. we describe the imaging appearance of lemierre syndrome in an adolescent female by both magnetic resonance imaging and computed tomography. this case illustrates the rapid onset and characteristic progression of the rare syndrome of lemierre. in addition, we used magnetic ...200010957863
human necrobacillosis, with emphasis on lemierre's syndrome.lemierre's syndrome is the classical presentation of human necrobacillosis. it is characterized by a primary infection in the head in a young, previously healthy person who subsequently develops persistent high fever and disseminated metastatic abscesses, frequently including a septic thrombophlebitis of the internal jugular vein. the main pathogen is fusobacterium necrophorum, an obligate anaerobic, pleomorphic, gram-negative rod. clinical microbiologists have a key role in alerting clinicians ...200010987717
lemierre's syndrome: a complication of acute oropharyngitis.lemierre's syndrome is a recognized but infrequently seen complication of acute oropharyngitis. in this case report the patient presented with acute sore throat that led to a bacteraemia with internal jugular vein thrombosis and subsequent cranial nerve palsies.200010992941
[lemierre syndrome secondary to malignant cervical adenopathy]. 200011039089
lemierre's syndrome. 200011089486
lemierre's syndrome.lemierre's syndrome is characterized by an oropharyngeal infection followed by internal jugular vein septic thrombophlebitis and metastatic emboli, most often to the lungs and joints. the syndrome is most commonly associated with the anaerobic gram-negative rod fusobacterium necrophorum. diagnosis is established with evidence of metastatic infection and internal jugular vein thrombophlebitis. ct is considered the diagnostic procedure of choice. treatment should include an extended course of a be ...200011095853
[picture of the month: lung abscess]. 200011107949
imaging quiz case 2. lemierre syndrome: septic thrombophlebitis of the internal jugular vein, or "postanginal" sepsis. 200011115292
thoracic complications of lemierre syndrome.lemierre syndrome is a severe, septicemic illness most commonly caused by the anaerobic gram-negative bacillus fusobacterium necrophorum. it is characterized by an acute oropharyngeal infection, with secondary septic thrombophlebitis of the internal jugular vein and frequent metastatic infections. this report of a patient with the lemierre syndrome is complemented by a review of the literature on the subject.200011121093
cerebral infarct and adult respiratory distress syndrome in a patient with postanginal sepsis. 200011168147
[lemierre syndrome: clinical and radiological characteristics of a rare disease].a benign oropharyngial infection without appropriate treatment can be complicated by a jugular vein thrombosis and disseminated septic embolies with deleterious pulmonary effects. this septic clinical picture most commonly known as lemierre syndrome is attributed to fusobacterium necrophorum, a gram negative anaerobic bacilli. we describe a case of a young patient who has presented this syndrome accompanied by typical pulmonary manifestations. adequate antibiotic treatment for 3 weeks associated ...200011217508
hemolytic uremic syndrome in an adolescent with fusobacterium necrophorum bacteremia.microorganisms may produce substances that disrupt the interaction between platelets and vascular endothelium, which has been associated with atypical hemolytic uremic syndrome (hus). we present the first reported case of fusobacterium necrophorum bacteremia that presented initially with atypical hus. antimicrobial therapy eradicated the patient's bacteremia, and plasmapheresis restored platelet-endothelial homeostasis. understanding the pathophysiologic mechanisms involved in atypical hus would ...200111228199
orbital cellulitis caused by fusobacterium report the case of a previously healthy young female who developed orbital cellulitis caused by fusobacterium necrophorum. we are unaware of previous reports of this condition caused by the same anaerobic, gram-negative, nonsporeforming bacterium and could find no reference to it in a computer search using medline.200111228318
[fusobacterium necrophorum septic shock from colonic origin with multiple abscesses]. 200111234682
bilateral forefoot gangrene secondary to lemierre's disease. 200111266497
lemierre's syndrome presenting as multiple lung abscesses.lemierre's syndrome is thrombophlebitis of the internal jugular vein (ijv), complicating an oropharingeal infection. the causative organism is fusobacterium, an anaerobic bacillus, and the syndrome typically occurs in previously healthy teenagers and young adults. thromboembolic metastases are a common sequela, and the lungs are most frequently affected. we present a case of a 25-year-old woman, who presented with multiple lung abscesses, in whom ijv thrombophlebitis was subsequently noted.200011274881
the effect of statherin and its shortened analogues on anaerobic bacteria isolated from the oral cavity.the susceptibility (mic) of 44 strains of anaerobic bacteria isolated from the oral cavity and 3 standard strains to statherin and its c-terminal fragments with sequences qyqqytf, yqqytf, qqytf, qytf and ytf was determined by means of plate dilution technique in brucella agar with 5% content of defibrinated sheep's blood, menadione and hemin. the culture was anaerobic. as shown, at concentrations from 12.5 to 100 microg/ml statherin and its c-terminal fragments inhibited the growth of anaerobic ...200011293657
lemierre's syndrome with spondylitis and pulmonary and gluteal abscesses associated with mycoplasma pneumoniae pneumonia.lemierre's syndrome, a systemic anaerobic infection caused by fusobacterium necrophorum, is characterized by an acute oropharyngeal infection, septic thrombophlebitis of the internal jugular veins, sepsis, and multiple metastatic infections. it commonly leads to pulmonary parenchymal abscesses and occasionally to septic arthritis, osteomyelitis, or liver or spleen abscesses. reported here is a case of spondylitis and pulmonary and gluteal abscesses that occurred as part of a classic presentation ...200111399017
electrophoretic mobility anomalies associated with pcr amplification of the intergenic spacer region between 16s and 23s ribosomal rna genes of fusobacterium necrophorum.pcr amplification of the intergenic spacer region (isr) between 16s and 23s rrna genes among subspecies of the anaerobic bacterium fusobacterium necrophorum gave identical patterns, with two forms of isr identified. however, extra bands resulting from anomalous electrophoretic mobility of amplified dna fragments with certain primer combinations were encountered. therefore, pcr assays relying solely on banding patterns may be unreliable, and supporting sequence analysis is essential for correct c ...200111412927
lemierre's syndrome.this is a case report of lemierre's syndrome in a 17-year-old male patient. lemierre's disease consists of suppurative thrombophlebitis of the internal jugular vein (sijvt) in the presence of oropharyngeal infection and can be complicated by septic pulmonary embolism. other causes of sijvt include deep neck infections and central venous catheterization. the disease usually results from gram-negative anaerobic organisms such as fusobacterium necrophorum.200111422899
[mastoidal infection due to fusobacterium necrophorum in children. report of two cases]. 200111446920
pharyngitis followed by hypoxia and sepsis: lemierre syndrome. 200111447525
a 47-year-old man with a sore throat. 200111453077
cloning, sequencing, and expression of the leukotoxin gene from fusobacterium necrophorum.fusobacterium necrophorum is a gram-negative, rod-shaped, anaerobic bacterium that is a primary or secondary etiological agent in a variety of necrotic purulent infections in animals and humans. included are diseases of cattle such as liver abscesses and foot rot, which have economically important consequences for the cattle industry. the major virulence factor of this bacterium is leukotoxin, a secreted protein of high molecular weight active against leukocytes from ruminants. the screening of ...200111500416
differentiation of fusobacterium necrophorum subspecies from bovine pathological lesions by rapd-pcr.nineteen strains from bovine abscesses identified as fusobacterium necrophorum by the vpi method were examined by other methods. the api 20a test kit characterized all 19 strains as f. necrophorum. seven of the strains had haemagglutinating activity and were classified as f. necrophorum subspecies necrophorum, and the remaining, 12 nonhaemagglutinating strains, were classified as f. necrophorum subspecies funduliforme. we used rapd-pcr with a 10-mer oligonucleotide primer, w1l-2, to confirm this ...200111506931
collagenolytic activity of a cell wall preparation from fusobacterium necrophorum subsp. necrophorum.a collagenolytic preparation of fusobacterium necrophorum subsp. necrophorum was derived from the bacterial cell. it was further treated for gel permeation with toyopearl hw 50, followed by sepharose 4b column chromatography. in sodium dodecyl sulphate polyacrylamide gel electrophoresis, the final preparation exhibited one definite band and at least one faint band. it was inactivated completely by adjusting the ph to 4.0 or by heating at 80 degrees c for 30 min.200111548204
fusobacteriosis in captive wild-caught pronghorns (antilocapra americana).an outbreak of fusobacterium necrophorum-induced septicemia occurred in a group of 40 captive wild-caught pronghorns (antilocapra americana). primary pododermatitis or necrotic stomatitis progressed to produce fatal septicemia with metastatic lesions in the forestomachs, lung, liver, and cecum in 38 of the animals. two remaining animals were euthanatized because of chronic pododermatitis. housing the animals in a pasture previously used by bovids and heavy rains with persistence of ground water ...200111572563
lemierre's syndrome. sepsis complicating an anaerobic oropharyngeal infection.previously healthy people without interfering conditions are rarely affected by anaerobic infections. we report a young patient with extended septic emboli in the lungs, after an episode of sore throat, due to anaerobic bacteremia with fusobacterium necrophorum. the first description of oropharyngeal infection complicated by sepsis was given by lemierre in 1936. knowledge of lemierre's syndrome should lead to early recognition and prompt action against this sporadic and possible fatal illness.200111578793
lemierre's syndrome.we describe a 32-year-old woman who had temperatures increasing over 7 days from 100.7 degrees f to 104.0 degrees f. she had an upper respiratory infection and swelling of the left side of the neck. she was diagnosed with lemierre's syndrome.200111592746
[lemiere's syndrome. thrombophlebitis of the internal jugular vein induced by oropharyngeal lesion. a case report].nowadays due to the use of antibiotics the occurrence of a general complication of tonsillitis is extremely rare. lemierre in 1936 throroughly described one of these events. we introduce a case of postanginal septicaemia detected in a previous healthy young woman. we also undertake a review of lemierre's syndrome cases published within the last seven years in the english and spanish literature, giving special attention to diagnostical methods and therapeutical strategies.200111692429
antimicrobial activity of some pacific northwest woods against anaerobic bacteria and yeast.extracts of woods commonly used for animal bedding were tested for antimicrobial activity. essential oils from alaska cedar (chamaecyparis nootkatensis), western juniper (juniperus occidentalis) and old growth douglas fir (pseudotsuga menziesii) as well as methanol extracts of wood from these trees plus western red cedar (thuja plicata) and ponderosa pine (pinus ponderosa) were tested for antimicrobial activity against anaerobic bacteria and yeast. the test microbes included fusobacterium necrop ...200111746838
[febrile syndrome after closed abdominal trauma]. 200111747794
[fusobacterium necrophorum pyomiositis]. 200111747802
leukotoxins of gram-negative bacteria.leukotoxins are a group of exotoxins that produce their primary toxic effects against leukocytes, especially polymorphonuclear cells (pmns). leukotoxins include a variety of chemicals ranging from 9,10-epoxy 12-octadecenoate, a fatty acid derivative secreted by leukocytes themselves, to proteins such as rtx (repeats in toxin). this review focuses on leukotoxins of three species of gram-negative bacteria, mannheimia (pasteurella) haemolytica, actinobacillus actinomycetemcomitans, and fusobacteriu ...200211750142
fusobacterium equinum sp. nov., from the oral cavity of horses.two strains of gram-negative, anaerobic, non-sporulating rod that were isolated from the normal oral cavity and oral-associated disease from horses and which phenotypically resembled fusobacterium necrophorum were characterized by sequencing of the 16s rrna gene, phylogenetic analysis, dna-dna hybridization and phenotypic characterization. the results placed the novel strains as distinct members of the genus fusobacterium. the novel species fusobacterium equinum sp. nov. is proposed, with strain ...200111760934
[retrospective analysis of fusobacterium associated infections; experience at aomori prefectural hospital with 108 cases from 1995 to 1999].we experienced 108 cases of fusobacterium associated infections, including otolaryngeal, oral, pleuropulmonary, intraabdominal, skin and soft tissue infections, at aomori prefectural hospital during the 5 year-period from 1995 to 1999. a total of 433 organisms, included 113 fusobacterium spp. (80 fusobacterium nucleatum, 18 fusobaterium necrophorum, 5 fusobacterium varium, 4 fusobacterium mortiferum, 6 fusobacterium spp.), were recovered with an average of 4.0 organisms per case of the 108 cases ...200211852471
fusobacterium necrophorum infections in england and wales response to a marked increase in both the number of fusobacterium necrophorum bacteraemia reports to the phls communicable disease surveillance centre and the number of f. necrophorum isolates referred to the phls anaerobe reference unit in 1999, the data from both sources on f. necrophorum infections were reviewed for the decade 1990-2000. there were 208 reports of f. necrophorum bacteraemia (average 19/year; range 14-34/year) with a peak in incidence in the late winter months; 68% were from ...200211871622
pharmacokinetics of ceftiofur in plasma and uterine secretions and tissues after subcutaneous postpartum administration in lactating dairy cows.a study was conducted to measure concentrations of potentially active ceftiofur derivatives, in plasma, in uterine tissues (endometrium and caruncles) and in uterine secretions at different time points after a single subcutaneous administration of ceftiofur hydrochloride (excenel rtu sterile suspension) at the dose of 1 mg/kg body weight in holstein-friesian dairy cows. the animals (n=4) were injected within 24 h of calving, after expulsion of the foetal membranes. plasma, lochial fluid, caruncl ...200211874524
clinical and bacteriological aspects on the use of oxytetracycline and flunixin in primiparous cows with induced retained placenta and post-partal endometritis.retention of the fetal membranes and post-partal endometritis (rfm) are common problems in dairy cows. treatment often includes manual removal of the placenta in combination with antibiotic treatment. earlier studies have shown that cows with endometritis post-partum have a strong tendency to recover spontaneously. the present study focused on treatments of post-partal endometritis with the prostaglandin synthesis inhibitor, flunixin (f) either alone or combined with oxytetracycline (t). the stu ...200111885742
lemierre's syndrome as a consequence of acute supraglottitis.lemierre's syndrome comprises internal jugular vein thrombosis following oropharyngeal sepsis and is a rare and serious condition. it is most commonly caused by the anaerobe fusobacterium necrophorum and typically presents as metastatic sepsis to the lungs and joints. thrombosis is demonstrated by computed tomography (ct) of the neck, and it is routinely treated with intravenous antibiotics and anti-coagulation. we describe a case of lemierre's syndrome following acute supraglottitis. the clinic ...200211893267
16s-23s rdna internal transcribed spacer sequences for analysis of the phylogenetic relationships among species of the genus fusobacterium.the 16s-23s rdna internal transcribed spacer (its) regions of all currently defined fusobacterium species and related taxa such as leptotrichia buccalis, sebaldella termitidis and streptobacillus moniliformans, were analysed to examine inter- and intraspecies as well as subspecies relationships. for the its-amplification, a new eubacterial universal primer pair was designed and used. the majority of the fusobacterium strains, along with l. buccalis showed one major, and two to three weaker, dist ...200211931161
haemophilus parainfluenzae and fusobacterium necrophorum liver abscess: a case report.liver abscess is a potentially life-threatening disease. the clinical features of pyogenic liver abscess are variable and probably correlate with a variety of pathogenic microorganisms and underlying diseases that may be involved. the most common pathogen of liver abscess in taiwan is klebsiella pneumoniae. diabetes mellitus and hepatobiliary calculus are major diseases associated with liver abscess. haemophilus parainfluenzae is a commensal of the upper respiratory tract, but is an uncommon iso ...200211950124
bilateral lemierre's syndrome: a case report and literature review.lemierre's syndrome is characterized by thrombosis of the internal jugular vein that develops following an oropharyngeal infection. sepsis and septic metastases frequently ensue and affect the lungs, the musculoskeletal system, and occasionally the liver. most cases are caused by infection with fusobacterium necrophorum. this infection responds to antibiotic therapy with beta-lactamase-resistant compounds that exert good anaerobic coverage. anticoagulation and surgical intervention can be helpfu ...200211987741
characterization of the 16s-23s rrna intergenic spacer regions among strains of the fusobacterium necrophorum cluster.the 16s-23s rrna intergenic spacer regions (isrs) of fusobacterium necrophorum subsp. necrophorum and f. necrophorum subsp. funduliforme were characterized. products of two sizes, about 360 bp (small) and 530 bp (large), were generated by pcr amplification from the 16s-23s rrna isr of all the strains tested. the large and small 16s-23s rrna isrs of f. necrophorum exhibited a level of sequence similarity of 93.9% to 99.7% and 94.2% to 98.6% homologies within the species, respectively. only the la ...200211999450
oro-facial gangrene (noma/cancrum oris): pathogenetic mechanisms.cancrum oris (noma) is a devastating infectious disease which destroys the soft and hard tissues of the oral and para-oral structures. the dehumanizing oro-facial gangrenous lesion affects predominantly children ages 2 to 16 years, particularly in sub-saharan africa, where the estimated frequency in some communities varies from 1 to 7 cases per 1000 population. the risk factors are poverty, malnutrition, poor oral hygiene, residential proximity to livestock in unsanitary environments, and infect ...200012002813
clinical problem solving: radiology. radiology quiz case 2: lemierre syndrome. 200212003598
necrobacillosis--a resurgence?necrobacillosis is a rare life threatening illness caused by fusobacterium necrophorum. it usually affects previously healthy adolescents and presents as symptomatic pharyngeal infection followed by bacteraemia and metastatic abscesses. a high degree of clinical suspicion is needed because there is often a delay between the presentation of sore throat and the development of systemic illness. the clinical and radiological features of four cases of necrobacillosis are reported and a review of the ...200212014927
lung abscess with neck swelling. 200212026250
oropharyngeal necrobacillosis with septic thrombophlebitis and pulmonary embolic abscesses: lemierre's syndrome in a new zealand white rabbit.lemierre's syndrome, oropharyngeal infections induced by anaerobic bacteria, leading to fatal septic thrombophlebitis of the internal jugular vein and pulmonary embolic abscesses in humans, was diagnosed in a 6-month-old, male, new zealand white rabbit. after acute onset of anorexia, lethargy, and depression, the rabbit died suddenly despite emergency clinical care. necropsy revealed swelling, necrosis, and abscess in the soft tissues around the left caudal mandibular ramus, oral mucosa, and mol ...199912086416
investigation of postanginal sepsis and lemierre's syndrome in the south west peninsula.we describe a retrospective case series of postanginal sepsis and lemierre's syndrome (ls) identified from laboratory records of fusobacterium necrophorum isolates and from clinical case note review. some patients presented with sore throat, tonsillitis, quinsy or a septicaemic illness, whereas others presented with symptoms related to metastatic septic lesions with later recognition of the significance of the preceding sore throat. patients with otitis media and mastoiditis are included in the ...200112109395
a critically ill young man with septic emboli to the lungs. 200212113856
fusobacterium necrophorum leukotoxin induces activation and apoptosis of bovine leukocytes.fusobacterium necrophorum, a gram-negative, rod-shaped, anaerobic bacterium, is a primary or secondary etiological agent in a variety of necrotic, purulent infections in humans and animals. its major virulence factor is leukotoxin, a high-molecular-weight secreted protein, primarily toxic to ruminant leukocytes. in this study, bovine peripheral blood leukocytes were exposed to various concentrations of immunoaffinity-purified leukotoxin and the cytotoxicity was analyzed by flow cytometry and sca ...200212117974
immunohistochemical and ultrastructural identification of fusobacterium necrophorum subsp. necrophorum in bovine fatal necrotizing glossitis.a 37-day-old male japanese black calf showing marked salivation and leucocytosis died and was examined the tissues histologically. histological lesions were characterized by severe focal necrotic glossitis on the ventral side of the root of the tongue. immunohistochemically, fusobacterium necrophorum subsp. necrophorum antigen was detected in the necrotic tissues and its distribution corresponded to that of the gram-negative, nonsporeforming, long filamentous organisms. ultrastructural similarit ...200212130839
lemierre's syndrome: an unusual cause of sepsis and abdominal describe a patient with lemierre's syndrome who presented with acute abdominal findings and to describe the evaluation and treatment of this syndrome.200212130992
update on the taxonomy and clinical aspects of the genus fusobacterium.the genus fusobacterium currently includes 13 species. fusobacterium nucleatum, the most frequently encountered species in humans, is heterogeneous and currently includes 5 subspecies. a potentially new subspecies of f. nucleatum that is intrinsically quinolone-resistant and phylogenetically separate from the other 5 subspecies has been identified from dog and cat oral flora. two subspecies have been described for fusobacterium necrophorum, and a new species, fusobacterium equinum, which is rela ...200212173104
Displaying items 601 - 700 of 1564