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lemierre syndrome in a 5-month-old male infant: case report and review of the pediatric literature.to report, to the best of our knowledge, the youngest patient with lemierre syndrome.200818779698
advanced lemierre syndrome requiring surgery.a 38-year-old homeless man was admitted with a 2-week history of a sore throat, increasing shortness of breath, and high fever. clinical examination showed enlarged and tender submandibular and anterior cervical lymph nodes and a pronounced enlargement of the left peritonsillar region (figure 1a). ct scan of the throat and the chest showed left peritonsillar abscess formation, occlusion of the left internal jugular vein with inflammatory wall thickening and perijugular soft tissue infiltration, ...200818791836
stimulation of epithelial cell matrix metalloproteinase (mmp-2, -9, -13) and interleukin-8 secretion by fusobacteria.bacterial pathogens involved in periodontal diseases exert their destructive effects primarily by stimulating the host cells to increase their secretion of proinflammatory cytokines and matrix metalloproteinases (mmps). this study aimed to determine the epithelial cell matrix metalloproteinase and interleukin-8 (il-8) secretion upon exposure to fusobacteria.200818793368
fusobacterial infections: clinical spectrum and incidence of invasive disease.clinically significant infections caused by members of the genus fusobacterium are rare. we sought to describe the spectrum of clinical disease and epidemiology of these conditions presenting to an acute hospital over a five year period.200818805588
an overview of the microbiology of acute ear, nose and throat infections requiring hospitalisation.this study is the first to provide an extensive overview of the microbiology of acute ear, nose and throat infections requiring hospitalisation. all 2,028 cases of acute infections admitted between 1 january 2001 and 31 december 2006 were reviewed to assess the use of pre-admission antibiotics, microbiological results, antibiotic and surgical management and length of hospitalisation. infections of the oropharynx accounted for the vast majority of admissions, followed by ear infections, and cutan ...200918830726
sodium sulfamethazine in treatment of actinomyces necrophorus infections of the bovine foot. 194818891528
isolation and maintenance of an l 1-like culture from fusiformis necrophorus (syn. bact. funduliforme, bacteroides funduliformis). 194718910323
lemierre's syndrome with fourth nerve palsy.lemierre's syndrome is characterized by acute oropharyngeal infection with secondary internal jugular vein thrombophlebitis and subsequent metastatic infections. the anaerobe fusobacterium necrophorum is the usual etiologic agent, although other microorganisms, including streptococcus, staphylococcus, enterococcus, bacteroides, and lactobacilli, may be present alone or in combination with f. necrophorum. common sites of metastatic infection include the lungs and joints. thromboembolic complicati ...200918930667
effects of feeding polyclonal antibody preparations on rumen fermentation patterns, performance, and carcass characteristics of feedlot steers.in a previous study, preparations of polyclonal antibodies (pap) against fusobacterium necrophorum (pap-fn) or streptococcus bovis (pap-sb) were successful in decreasing ruminal counts of target bacteria and increasing ruminal ph in steers fed high-grain diets. the objective of this study was to evaluate the effects of feeding pap-fn or pap-sb on performance, carcass characteristics, and ruminal fermentation variables of feedlot steers. in exp. 1, during 2 consecutive years, 226 or 192 angus and ...200818955541
[lemierre syndrome: a complication of an oropharyngeal infection].we report a case of lemierre syndrome in a healthy infant, initially presenting with otitis media and angina. lemierre syndrome is a disease that every pediatrician must know. early diagnosis and treatment with antibiotics are necessary to decrease mortality. a review of the history and the complications of lemierre syndrome is presented.200818990551
lemierre's syndrome.lemierre's syndrome is a rare disease that results in an oropharyngeal infection, which precipitates an internal jugular vein thrombosis and metastatic infection. fusobacterium necrophorum is an anaerobic gram-negative bacillus and has been identified as the causative agent. we describe the case of a young girl whose presentation and diagnosis were confounded by a history of valvular heart disease. infection of heart valves can produce many of the signs and symptoms associated with lemierre's sy ...201119002548
variation in fusobacterium necrophorum strains present on the hooves of footrot infected sheep, goats and cattle.footrot is a disease of sheep, goats and cattle that causes losses in production and raises welfare issues world-wide. the disease is characterised by destruction of the hard keratin of the hoof leading to lameness, and both dichelobacter nodosus (d. nodosus) and fusobacterium necrophorum (f. necrophorum) are thought to be involved in the etiology of this disease. while a lot is known about the genetic diversity of d. nodosus, very little is known about variation in f. necrophorum, especially as ...200919019570
frequency, microbial interactions, and antimicrobial susceptibility of fusobacterium nucleatum and fusobacterium necrophorum isolated from primary endodontic infections.this study assessed the prevalence and microbial interactions of fusobacterium nucleatum and fusobacterium necrophorum in primary endodontic infections from a brazilian population and their antimicrobial susceptibility to some antibiotics by the e-test. one hundred ten samples from infected teeth with periapical pathologies were analyzed by culture methods. five hundred eighty individual strains were isolated; 81.4% were strict anaerobes. f. nucleatum was found in 38 root canals and was associat ...200819026872
factor h binding as a complement evasion mechanism for an anaerobic pathogen, fusobacterium necrophorum.fusobacterium necrophorum subspecies funduliforme is an obligate anaerobic gram-negative rod causing invasive infections such as the life-threatening lemierre's syndrome (sore throat, septicemia, jugular vein thrombosis, and disseminated infection). the aim of our study was to understand if and how f. necrophorum avoids c activation. we studied 12 f. necrophorum subsp. funduliforme strains isolated from patients with sepsis. all strains were resistant to serum killing after a 1-h incubation in 2 ...200819050282
lemierre's syndrome due to community-acquired meticillin-resistant staphylococcus aureus infection and presenting with orbital cellulitis: a case report.lemierre's syndrome is septic thrombophlebitis of the internal jugular vein leading to metastatic septic complications following an oropharyngeal infection. it is usually caused by the anaerobe, fusobacterium necrophorum. of late, meticillin-resistant staphylococcus aureus is increasingly being recognised as a cause of community-acquired skin and soft tissue infections. we report a rare case of lemierre's syndrome caused by community-acquired meticillin-resistant staphylococcus aureus infection.200819063718
[case imaging: lemièrre's syndrome with sepsis pulmonary emboli and pleural empyema]. 200819100205
lemierre syndrome following oropharyngeal infection: a case series.lemierre syndrome is a potentially fatal complication of oropharyngeal infections that is characterized by jugular vein thrombosis and septic emboli. fusobacterium spp. are the causative organisms. patients typically present with high fevers, neck pain, and pulmonary symptoms. prompt clinical diagnosis and treatment with appropriate antibiotics are critical. anticoagulation for this syndrome is controversial. we present 3 cases within a 12-month period of young, family practice patients seen wit ...200919124638
a case of lemierre syndrome. 200919139613
an unusual sore throat. 200819143328
[atypical sore throats]. 200919167864
a 40-day siege. 200919185090
dichelobacter nodosus, fusobacterium necrophorum and the epidemiology of footrot.footrot is a debilitating disease of sheep resulting in lameness, production losses and suffering. to study the basic bacteriology of the disease, a survey was initiated across commercial farms and non-commercial research flocks to compare the bacteriology of symptomatic footrot infected sheep with healthy asymptomatic sheep. of the 80 farmers initially contacted, 14 collected hoof swabs and returned the swabs by post. following dna extraction, species-specific pcr was used to identify if dichel ...200919239925
lemierre syndrome: a case of a rarely isolated microorganism, staphylococcus auerus.lemierre syndrome is an extremely rare complication of mild-to-moderate pharyngeal infections that causes septic embolization to the lungs and other distant sites. one-third of cases present a polymicrobial bacteremia, although the most isolated microorganism is fusobacterium necrophorum. a case of postanginal sepsis caused by a rarely isolated microorganism, staphylococcus auerus, in a geriatric patient is reported.200919247251
the detection of dichelobacter nodosus and fusobacterium necrophorum from footrot lesions in new zealand goats. 200919248838
lkta-encoded leukotoxin is not a universal virulence factor in invasive fusobacterium necrophorum infections in animals and man. 200919273652
orbital abscesses caused by fusobacterium necrophorum.the authors describe 2 cases of young men who presented with pansinusitis and fusobacterium necrophorum orbital abscesses. the first patient had a complicated clinical course including epidural abscess formation and meningitis. he underwent surgical evacuation of the abscesses and sinus drainage and required long-term broad spectrum antibiotic therapy with full recovery. the second patient had a clinical course complicated by f. necrophorum septicemia. he required surgical evacuation of the absc ...200919273938
[fusobacterium necrophorum: from tonsillitis to lemierre's syndrome].fusobacterium necrophorum plays a role in non-gas-tonsillitis in adolescents and probably also in small children with recurrent otitis media. anaerobic culture on selective anaerobic media is recommended to detect f. necrophorum and treat such patients. denmark sees at least 20 annual cases of lemierre's syndrome with a mortality reaching 9%. early suspicion of lemierre's syndrome in adolescents with non-gas-tonsillitis, who develop septicaemia, pulmonary symptoms and unilateral swelling on the ...200919284917
[can anaerobic culture of throat swabs prevent lemierre's syndrome?].six cases of lemierre's syndrome were reported from 2004 to 2007 at viborg hospital, corresponding to 33 cases per year in denmark. all six patients were healthy younger persons presenting with a suspected bacterial tonsillitis which had been found strep a antigen negative. fusobacterium necrophorum was found in throat swabs by anaerobic culture on selective media and/or by real-time pcr. we recommend that all patients 10 to 40 years of age with strep a antigentest negative bacterial tonsillitis ...200919284918
pyogenic liver abscess with prevotella species and fusobacterium necrophorum as causative pathogens in an immunocompetent patient.pyogenic liver abscess of odontogenic origin in an immunocompetent patient is extremely rare. we report an immunocompetent 25-year-old male hepatitis b carrier with severe dental disease that led to the development of liver abscess. a periapical abscess in the upper left molar area was seen on his dental x-ray. two sets of blood cultures grew prevotella species, bacteria that are commonly found inside the oral cavity. bacterial culture of the liver abscess drainage sample grew both prevotella an ...200919293042
lemierre's syndrome: a serious complication of an odontogenic infection.necrobacillosis, postanginal septicaemia or lemierre's syndrome is characterised by suppurative thrombophlebitis of the internal jugular vein with embolization to several sites, including the lungs. we report the case of a 38-year-old man who was initially hospitalized because of odontogenic cellulitis. given the deterioration of his clinical state (septic shock and multiple organ failure), neck computed tomography was performed, revealing both cervical and parotid abscesses, and thrombosis of t ...200919300351
lemierre's syndrome followed by acute respiratory distress syndrome successfully rescued by antibiotics and hemoperfusion with polymyxin b-immobilized fiber.lemierre's syndrome is characterized by a primary oropharyngeal infection in a young healthy person who subsequently develops septic thrombophlebitis of the internal jugular vein and metastatic abscesses. we here report an uncommonly severe case of lemierre's syndrome with acute respiratory distress syndrome (ards), in which polymyxin b-immobilized fiber (pmx) was used as supportive therapy. a 30-year-old, previously healthy man presented with sore throat, fever, rigor, and dyspnea. chest comput ...200919305053
lemierre syndrome complicating otitis externa: case report and literature review.background: septic thrombophlebitis of the internal jugular vein, known as lemierre syndrome, is a rare disorder usually caused by fusobacterium necrophorum, a gram-negative anaerobic organism that normally inhabits the oropharynx. lemierre syndrome usually follows primary oropharyngeal infections and affects previously healthy adolescents and young adults in a characteristic manner, often with fatal results if left untreated. there have been a significantly increasing number of reported cases o ...200919327936
case report: atypical lemierre's disease secondary to porphyromonas asaccharolytica.lemierre's disease, also known as 'postanginal sepsis', 'necrobacillosis', or 'internal jugular vein thrombosis', is a rare but serious emerging infection. although lemierre's disease remains rare, the number of reported cases has risen in recent years as more judicious antimicrobial prescribing practices for viral upper respiratory tract infections are being employed by primary care practitioners, allowing the propagation of bacterial superinfection. the most commonly implicated pathogen is fus ...200919390440
detection of fusobacterium necrophorum and dichelobacter nodosus in lame cattle on dairy farms in new zealand.lameness in the dairy industry in new zealand causes a problem in lost production, animal welfare and associated costs. to understand what bacteria may be present on the hooves of lame dairy cattle in this grass-fed system, samples were scraped from lame dairy cows and examined for the presence of fusobacterium necrophorum (f. necrophorum) and dichelobacter nodosus (d. nodosus) using the polymerase chain reaction (pcr). the pcr primers were designed to detect the presence of the lkta gene, which ...200919409584
an unusual cause of septic arthritis in a 16-year-old girl. 200919417573
a sore throat--potentially life-threatening?a sore throat, which is most commonly viewed as a minor ailment, can be a manifestation of a life-threatening disorder known as lemierre's syndrome caused by fusobacterium necrophorum. we report a new case of lemierre's syndrome that occurred in an otherwise healthy 18-year-old woman, who initially presented with fever and sore throat. the diagnosis was not made until a week later when blood cultures became available. this syndrome should be suspected until proven otherwise in any patient with s ...200919430936
identification of three immunodominant regions on leukotoxin protein of fusobacterium necrophorum.to analyze immunodominant regions of leukotoxin protein of fusobacterium necrophorum strain h05, a series of truncated forms of leukotoxin gene were expressed in escherichia coli using the vector pgex-6p-1 or pproex hta. the results of sds-page showed the truncated forms pl1, pl2, pl4, and pl5 were expressed in escherichia coli using the vector pgex-6p-1, and the truncated forms pl3 was expressed in escherichia coli using the vector pproex hta. these recombinant proteins were able to react with ...200919449113
"a forgotten disease": a case of lemierre syndrome.lemierre's syndrome is a rare but a life threatening condition which affects young healthy individuals, was first described by dr.andre lemierre in 1936. incidence rates are between 0.6 and 2.3 per million population. it is found more commonly in males, with a male to female ratio of approximately 2:1. its pathogenesis consists of the development of infectious thrombophlebitis in the internal jugular vein or one of its branches caused by a focal sepsis, mostly localized in the oropharynx, leadin ...200919468652
unusual presentation of lemierre's syndrome: two cases and a review.lemierre's syndrome is a potentially fatal disease that usually presents with oropharyngeal infection, followed by sepsis, thrombosis of the internal jugular vein and septic emboli. most cases are caused by the gram-negative, anaerobic fusobacterium necrophorum. we present two patients with an atypical presentation of lemierre's syndrome and a review. these cases illustrate that a positive blood culture for f. necrophorum, even without the presence of clinical symptoms pointing towards thrombosi ...200919491663
necrobacillosis: a case report of complicated fusobacterium necrophorum septicemia.necrobacillosis due to fusobacterium necrophorum is an uncommon anaerobic infection. it has a wide range of presentations and commonly presents as lemierre's syndrome. we present a case of necrobacillosis defined by f. necrophorum bacteremia with epidural and pararectal fluid collection without evidence of internal jugular vein thrombophlebitis.201019501182
[acute mastoiditis in children: can mastoidectomy be avoided?].mastoidectomy is the standard management for exteriorized mastoiditis. the objective of this study was to assess the results of conservative management of acute mastoiditis and to study the types of bacteria isolated and their sensitivity to antibiotics.200919524875
epidemiology of pharyngeal carriage of fusobacterium necrophorum. 200919528186
lemierre's syndrome: a systematic review.lemierre's syndrome is characterized by a history of recent oropharyngeal infection, clinical or radiological evidence of internal jugular vein thrombosis, and isolation of anaerobic pathogens, mainly fusobacterium necrophorum. it was once called the forgotten disease because of its rarity, but it may not be that uncommon after all. this review aims to provide physicians with an update on the etiology, management, and prognosis of lemierre's syndrome.200919554637
a 21-year-old man with fever and abdominal pain after recent peritonsillar abscess drainage.lemierre syndrome an extremely rare and unreported disease typically results from oropharyngeal infection and/or local tissue trauma with invasion of the parapharyngeal soft tissue with bacteria. once local tissue invasion occurs, internal jugular vein septic thrombophlebitis with or without metastatic complications may occur. the etiology of lemierre syndrome is generally fusobacterium necrophorum, reported to be present in approximately 80% of the cases. the outcome of lemierre syndrome in the ...200919555636
community-acquired methicillin-resistant staphylococcus aureus and lemierre syndrome.lemierre syndrome is usually caused by fusobacterium necrophorum, but we recently encountered a case due to methicillin-resistant staphylococcus aureus and complicated by sigmoid sinus thrombosis and cranial neuropathies. therapy may be made more difficult by unusual organisms and also create the need for therapy that penetrates into the central nervous system.200919701080
necrobacillosis resulting in isolated carotid thrombosis and massive stroke: a unique lemierre variant?we describe a healthy, young adult male patient who developed isolated carotid artery thrombosis and occlusion following acute pharyngitis due to fusobacterium necrophorum. we believe this is the first case of isolated occlusion of internal carotid artery (ica) with f.necrophorum without associated internal jugular vein (ijv) thrombosis. lemierre's syndrome (ls) is characterized by a history of recent oropharyngeal infection in previously healthy individuals, clinical or radiological evidence of ...200919733365
[from tonsillitis to coxitis].we present a 19-year-old woman with a throat infection, increased temperature, a positive mononucleosis monospot test and clinical signs of a lower respiratory tract infection. the diagnosis was thought to be mononucleosis complicated by bacterial pneumonia, but she was later found to have fusobacterium necrophorum in blood cultures. she subsequently developed metastatic abscesses in her lungs and hip joint and was diagnosed with lemierre's syndrome. this case report highlights the importance of ...200919756057
[an underestimated throat bacteria]. 200919756058
a vanishing disease can still happen.lemierre's syndrome is a rare disease in the antibiotic era which is characterised by oropharyngitis, thrombophlebitis and septic metastases, but it can still occur and early recognition of its characteristic features and commencement of appropriate treatment can be life saving. the case history is described of a middle-aged man with lemierre's syndrome who made an uneventful recovery following treatment with co-amoxiclav and metronidazole for 6 weeks.200919773506
fusobacterium necrophorum variants present on the hooves of lame pigs. 201019781870
lemierre syndrome and unexpected death in childhood.lemierre syndrome refers to necrotizing infections of the head due to fusobacterium necrophorum and has been called the 'forgotten disease' due to its rarity in the antibiotic era. recently, however, more cases have been documented in the literature suggesting that there has been an increase in incidence. a 10-year-old boy is reported who had a five-day history of ear infection, with the development of fever, drowsiness and ipsilateral neck swelling. unexpected cardiac arrest occurred soon after ...200919782321
lemierre's syndrome resulting from streptococcal induced otitis media and mastoiditis: a case report.lemierre's syndrome is an extremely rare and almost universally fatal disease characterized as thrombophlebitis of the internal jugular venous system with subsequent metastatic infection. fusobacterium necrophorum is the most common organism implicated in causation of lemierre's syndrome. group a streptococcus has mainly been observed as a polymicrobial organism in the syndrome. we report a rare finding of a rare disease where group a streptococcus was the sole organism triggering lemierre's syn ...200919830121
fusobacterium necrophorum: most prevalent pathogen in peritonsillar abscess in denmark.group a streptococci are commonly regarded as the most prevalent cause of acute bacterial tonsillitis and peritonsillar abscess (pta). however, the majority of pta aspirates also contain strains of anaerobes, and accumulating evidence indicates that fusobacterium necrophorum (fn) could be involved in acute tonsillitis. the purpose of the present study was to describe the epidemiology and bacteriology of pta in denmark, with particular emphasis on correlations between microbiological, clinical, a ...200919842975
in reference to lemierre's syndrome: a systematic review. 201019890952
[rare complications of lemierre's syndrome: septic sternoclavicular joint arthritis and cavitating pneumonia].we report a 27-year-old man who presented with a lemierre's syndrome associated with two uncommon complications: a septic sternoclavicular joint arthritis and a cavitating pneumonia.200919896753
[lemierre syndrome].lemierre's syndrome is a rare and severe condition, with a primary focus in the cervicofacial area and followed by thrombosis of the internal jugular vein and metastatic infections, most often pulmonary. the principal pathogen is fusobacterium necrophorum. less rare and associated with high mortality before antibiotics, lemierre syndrome had became exceptional until the increase in the number of cases in recent years. recovery is usually the rule, but often only after long convalescence and ofte ...201019914026
acute appendicitis is characterised by local invasion with fusobacterium nucleatum/necrophorum.acute appendicitis is a local intestinal inflammation with unclear origin. the aim was to test whether bacteria in appendicitis differ in composition to bacteria found in caecal biopsies from healthy and disease controls.201119926616
lemierre syndrome: a pediatric case series and review of literature.lemierre syndrome is a rare disease of the head and neck often affecting adolescents and young adults. classically, infection begins in the oropharynx with thrombosis of the tonsillar veins followed by involvement of the parapharyngeal space and the internal jugular vein. septicemia and pulmonary lesions develop as infection spreads via septic emboli. although a rare entity in modern times, lemierre syndrome remains a disease of considerable morbidity and potential mortality.201019944898
expand the pharyngitis paradigm for adolescents and young adults.current guidelines and review articles emphasize that clinicians should consider group a beta-hemolytic streptococcus in the diagnosis and management of patients with acute pharyngitis. recent data suggest that in adolescents and young adults (persons aged 15 to 24 years), fusobacterium necrophorum causes endemic pharyngitis at a rate similar to that of group a beta-hemolytic streptococcus. on the basis of published epidemiologic data, f. necrophorum is estimated to cause the lemierre syndrome-a ...200919949147
[septic osteomyelitis of the hip after fusobacterium necrophorum pharyngitis].case report: we report the case of a patient presenting with lemierre's syndrome with an initial atypical presentation due to a predominant hip localization. despite the adapted antibiotic treatment and surgical drainage, the patient relapsed. the bone and joint biopsy samples were sterile but the presence of the fusobacterium necrophorum was demonstrated by pcr. conclusion: lemierre's syndrome may have different clinical presentations, due to the localizations of septic emboli. careful attentio ...201019959308
fusobacterium necrophorum multiple abscesses in children with sickle cell disease. 201020002625
[phlegmon of the palm of the hand as initial manifestation of the lemierre syndrome].lemierre's syndrome is a rare disease in young otherwise healthy people showing septic embolism in the lungs and peripheral vessels. we report the case of a 19-year-old male patient who presented initially with a phlegmon of the right palm and beginning septic shock. during the clinical course a subcutaneous abscess of the left shoulder, multiple lesions of the lungs and a pericardial abscess were identified and lemierre's syndrome was diagnosed. in this case, positron emission tomography (pet) ...201020024523
direct 16s rrna gene sequencing of polymicrobial culture-negative samples with analysis of mixed chromatograms.two cases involving polymicrobial culture-negative samples were investigated by 16s rrna gene sequencing, with analysis of mixed chromatograms. fusobacterium necrophorum, prevotella intermedia and streptococcus constellatus were identified from pleural fluid in a patient with lemierre's syndrome and neisseria meningitidis and escherichia coli were identified from a petechia in a patient with meningococcal disease.201020035024
diagnostic microarray for human and animal bacterial diseases and their virulence and antimicrobial resistance genes.rapid diagnosis and treatment of disease is often based on the identification and characterization of causative agents derived from phenotypic characteristics. current methods can be laborious and time-consuming, often requiring many skilled personnel and a large amount of lab space. the objective of our study was to develop a spotted microarray for rapid identification and characterization of bacterial pathogens and their antimicrobial resistance genes. our spotted microarray consists of 489 70 ...201020035807
undetected lkta genes within fusobacterium necrophorum? 201020075116
eponym: the lemierre syndrome.fig. 1 dr. andre lemierre lemierre syndrome, also known as postanginal sepsis, is a severe complication of an acute oropharyngeal infection that results in septic thrombophlebitis of the ipsilateral internal jugular vein with subsequent septicemia, often complicated by metastatic infections. the usual agent in lemierre syndrome is fusobacterium necrophorum, a commensal bacillus of the oral cavity. after the advent of antibiotic therapy, especially in the 1960s and 1970s, when penicillin was freq ...201020107834
a life-threatening sore throat masquerading as swine flu. 201020152545
digital necrobacillosis in norwegian wild tundra reindeer (rangifer tarandus tarandus).outbreaks of digital necrobacillosis in norwegian wild tundra reindeer (rangifer tarandus tarandus) are described. the outbreaks occurred in late summer and autumn 2007 and 2008, subsequent to periods with an unusually high number of days with precipitation and high air temperature. lesions were generally restricted to one foot and the disease incidence was highest in calves. single limbs from 20 animals and six whole carcasses were submitted for laboratory examination. gross lesions were charac ...201020156626
lemierre's syndrome secondary to fusobacterium necrophorum infection, a rare cause of hepatic abscess.an 18-year-old male was admitted to the accident & emergency department with complaints of abdominal pain, vomiting and diarrhoea. he was clinically jaundiced and further ct scan suggested liver abscess. later on blood cultures showed gram-negative bacilli and a further liver aspirate culture confirmed the presence of the rare fusobacterium necrophorum. a diagnosis of hepatic abscess secondary to lemierre's syndrome was made and patient was treated with appropriate antibiotics. lemierre's syndro ...200920163040
lemierre's syndrome, reemergence of a forgotten disease: a case report.lemierre's syndrome is a rare disorder of young adults caused by the anaerobic bacterium, fusobacterium necrophorum and occasionally by other fusobacterium species (f. nucleatum, f. mortiferum and f. varium etc). the condition is characterized by a primary oropharyngeal infection with evidence of septic thrombophlebitis, exhibited by positive blood cultures, clinical or radiographic evidence of internal jugular vein thrombosis, and at least one metastatic focus. the incidence of lemierre's syndr ...200920181152
has lemierre's syndrome become a bacteriological diagnosis? 201020220725
a case of puerperal septicaemia due to fusiformis necrophorus. 194720258503
bacteroides funduliformis (fusiformis necrophorus). 194720266373
an indirect elisa for serodiagnosis of cattle footrot caused by fusobacterium necrophorum.a serodiagnostic elisa (rl-elisa) using recombinant truncated leukotoxin protein pl2 (aa 311-644) of fusobacterium necrophorum as antigen was developed for detection of antibodies against f. necrophorum from cattle footrot. in rl-elisa, the recombinant diagnostic antigen showed no cross-reaction with antisera against bovine foot and mouth disease virus, bovine rhinotracheitis virus, bovine viral diarrhea virus, bovine rotavirus type a, bovine escherichia coli, and bovine salmonella. the rl-elisa ...201020304080
cervical conization complicated by sepsis with lung and liver abscesses.extrapelvic infections complicating cervical conization are exceedingly rare.201020354422
should we expand the pharyngitis paradigm for adolescents and young adults? 201020368663
fatal case of fusobacterium necrophorum mitral endocarditis. 201020381526
screening and sequence analysis of the hemolysin gene of fusobacterium necrophorum.fusobacterium necrophorum is the main pathogen that causes numerous necrobacilloses. hemolysin is one of the major virulence factors involved in fusobacterial infections. in order to investigate the genetic basis of hemolytic activity and the regulation mechanism of the hemolysin expression, a genomic library was constructed from f. necrophorum dna by ligating dna fragments generated by partial hindiii digestion with puc18 vector. the screening of the genomic library with polymerase chain reacti ...201020452448
lemierre syndrome: unusual cause and presentation.lemierre syndrome is a potentially fatal condition after an oropharyngeal infection. it is characterized by thrombophlebitis of head and neck veins with systemic dissemination of septic emboli. the most frequently isolated pathogen is fusobacterium necrophorum. we report an unusual case of lemierre syndrome in a 4-year-old child caused by staphylococcus aureus, with multivisceral emboli to the brain, orbits, lungs, and heart valves. we also discuss its atypical clinical presentation, the crucial ...201020453794
[brain abscess as the first clinical manifestation of isolated pulmonary arteriovenous malformation without rendu-osler disease].brain abscesses occur in 5 to 13 % of patients with pulmonary arteriovenous malformation (pavm), more often present in rendu-osler-weber disease or hereditary hemorrhagic telangiectasia (hht).201120466398
lemierre-like syndrome: a series of unique cases. 201020488807
luc's abscess: the return of an old fellow.mastoiditis, subperiosteal abscess and sigmoid vein thrombosis are the most common suppurative complications of acute otitis media (aom). luc's abscess, a subperiosteal temporal collection, is an infrequent complication with a particularly benign course.201020502372
oropharyngeal infection with metastatic hand infection: an uncommon variant of lemierre's syndrome.lemierre's syndrome is caused by acute oropharyngeal infection with septic secondary thrombophlebitis of the internal jugular vein and metastatic infection. fusobacterium necrophorum is the most commonly implicated aetiological agent. the authors present the case of a healthy young man presenting with a history of general malaise and sore throat who developed septic metastatic complications in the left upper limb. he made a complete recovery after treatment with a combination of parenteral antib ...201020527653
detection of antibodies against fusobacterium necrophorum and porphyromonas levii-like species in dairy cattle with papillomatous digital dermatitis.bovine digital epidermitis involves different pathologies, including pdd, interdigital dermatitis, and foot rot. bacteriological and molecular biological studies suggest that these are multimicrobial infections. during our study on the isolation of treponemes from biopsies of pdd, colonies producing black pigment were isolated frequently from the primary cultures, suggesting that porphyromonas species were present. moreover, 16s rrna genes of fusobacterium necrophorum and porphyromonas levii-lik ...201020536732
[identification of anaerobic bacteria isolated from various clinical specimens and determination of antibiotic susceptibilities].routine isolation, identification and susceptibility testing of anaerobic bacteria present several difficulties leading to defects in the determination of local susceptibility patterns which will guide empirical treatment protocols. this study was carried out to identify the anaerobic bacteria isolated from various clinical materials obtained from the suspected patients with anaerobic infection and to determine the antibiotic susceptibilities against several antibiotics. one hundred clinical spe ...201020549955
[lemierre syndrome: several clinical features of "a forgotten disease"].lemierre syndrome (ls) is considered as a forgotten disease since the beginning of penicillin. the lack of use of beta-lactamase inhibitors antibiotics together with the increase in the use of macrolids or second-generation and third-generation cephalosporins for oropharyngeal processes has led to an increasing incidence. we propose to review all ls cases seen in an emergency department over the last 5 years.201020570017
lemierre syndrome from an odontogenic source: a review for dentists.lemierre syndrome, which can result from a recent oropharyngeal or odontogenic infection, is characterized by clinical or radiographic signs of thrombosis of the internal jugular vein, distant infected emboli and the presence of anaerobic pathogens, usually fusobacterium necrophorum. the septic emboli resulting from the infected thrombophlebitis of the internal jugular vein give the syndrome its constellation of central nervous system, pulmonary and many other manifestations including septic sho ...201020579443
neurological complications in two children with lemierre syndrome.lemierre syndrome is a distinct clinical syndrome comprising oropharyngeal sepsis and fever, internal jugular vein thrombosis and remote septic metastases caused by fusobacterium species. the mortality rate was historically high and although use of antibiotics led to a dramatic fall in incidence, a resurgence has been seen recently. a 14-year-old male developed lemierre syndrome after tonsillitis. there was extensive leptomeningitis, especially over the clivus, causing 6th and 12th cranial nerve ...201020584047
lemierre's and lemierre's-like syndromes in association with infectious mononucleosis.this study aimed to review cases of lemierre's and lemierre's-like syndromes in paediatric patients, to examine a possible association with epstein-barr virus as a predisposing factor, and to assess the impact of this virus on the severity of illness.201020602850
[fever and dysphagia of a young woman].we report the case of a 39-year old patient with septicemia treated for pharyngitis with antibiotics since a few days. she wasn't able to swallow her antibiotics anymore because of dysphagia. radiologic examination revealed pulmonary infiltrates and vena iugularis interna-thrombosis. these findings and anamnesis led to the diagnosis of lemierre syndrome inspite of lacking detection of bacteria. after changing the antibiotic therapy and start of anticoagulation further course of illness was favor ...201020607669
lemierre's syndrome with paradoxical emboli.lemierre's syndrome is a rare anaerobic oropharyngeal infection complicated by internal jugular thrombosis, the predominant etiology is fusobacterium necrophorum. septic emboli to lungs and distant organs have been described, however, to date there have been no published cases associated with embolization across a patent foramen ovale. we describe a case of lemierre's syndrome with septic arterial emboli resulting in multiple cerebral abscesses and cutaneous manifestations. the outcome was favor ...201020647662
lemierre syndrome caused by co-infection by arcanobacterium haemolyticum and fusobacterium necrophorum. 201020661621
commentary: a confusing fusobacterium infection. 201020680922
lemierre's syndrome mimicking leptospirosis.lemierre's syndrome is a suppurative thrombophlebitis involving the internal jugular vein, most commonly associated with fusobacterium necrophorum, usually a complication of oropharyngeal infections. this syndrome is rare and is often overlooked. we present a case of sepsis mimicking initially severe leptospirosis (weil's disease) due to acute febrile illness with multiorgan failure and hyperbilirubinemia. finally, blood cultures revealed fusobacterium necrophorum and computed tomography (ct) de ...201020680923
a teenager with sore throat and neck pain. 201020724333
fusobacterium necrophorum bacteremic tonsillitis: 2 cases and a review of the literature.fusobacterium necrophorum can cause endemic pharyngitis and the lemierre syndrome. four previous case reports and one epidemiologic study have documented that some f. necrophorum pharyngitis patients develop bacteremia without developing the complete lemierre syndrome. we report two more patients who have bacteremic f. necrophorum pharyngitis. we summarize the clinical presentation of these six patients. all received early diagnosis and excellent response to antibiotics. we speculate that prompt ...201020813196
lemierre syndrome: no delays in management. 201020837271
lemierre syndrome and nosocomial transmission of fusobacterium necrophorum from patient to physician.human-to-human transmission of fusobacterium necrophorum has not been described before.201020862633
isolation of two novel fusobacterium necrophorum variants from sheep in australia. 201020869818
ovine footrot: new approaches to an old disease.footrot is a bacterial disease that has substantial economic and welfare impacts in sheep and can be difficult to manage. research is focussed on reducing the impact that footrot has on farmers and their flocks and better understanding the aetiology of the disease. key areas of current research include, developing better vaccines, deploying tailored vaccines in a specific and targeted fashion on individual farms, analysing and developing better farm management practices to suit specific sheep fa ...201020926208
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