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[severe infections due to streptococcus milleri in children].streptococcus milleri (s. milleri) is found in healthy individuals in the mouth, nasopharynx, throat, vagina and in feces, and has been reported to be isolated from several infectious diseases in man, particularly from abscess in various parts of the body. we report two cases of severe infections due to s. milleri isolated from subdural abscess and pleural empyema. [case 1] 13 year old boy who had been healthy until he was noticed to have meningeal signs and was diagnosed as left subdural absces ...19911680938
measurement of the human immune response to meningococcal lipooligosaccharide antigens by using serum to inhibit monoclonal antibody binding to purified lipooligosaccharide.we developed a human inhibition monoclonal enzyme-linked immunosorbent assay (himelisa) to investigate the human immune response to the lipooligosaccharides (los) of neisseria meningitidis. monoclonal antibodies (mab) were used to define seven epitopes on four los molecules of a meningococcal strain (126e) previously shown to express immunogenic los epitopes. the assay could distinguish epitope-specific antibody within whole sera. neither the specificity nor the amount of the antibody measured b ...19901694820
the relationship of serum igg antibody titers to periodontal pathogens to indicators of the host response in crevicular fluid.in this study; the relationship of indicators of the local host response in gingival crevicular fluid (gcf) to the serum antibody titer to periodontal pathogens was examined. 15 patients with chronic adult periodontitis were studied. gcf was collected and analyzed for the total amount of igg, igm, the lysosomal enzyme b-glucuronidase (bg) and alpha-2-macroglobulin (alpha 2m). at the same examination, serum from these patients was collected, and enzyme-linked immunosorbent assays used to determin ...19901696949
permeability alteration of the sarcolemmal membrane, particularly at the site of macrophage contact, in experimental chronic trypanosoma cruzi myocarditis in mice.sarcolemmal membrane permeability characteristics have been investigated, particularly at the site of macrophage contact, in experimental chronic trypanosoma cruzi myocarditis in balb/c mice, employing ruthenium red (rr) as an electron tracer. the ultrastructural features of the myocardium from infected animals were similar to those previously described. briefly, focal myocarditis was detected, with areas of myocytolytic necrosis, atrophic myofibres, an inflammatory response composed of mononucl ...19901698094
[studies on defense effects of recombinant human granulocyte colony-stimulating factor (g-csf) to infections. ii. priming effect for superoxide production by human neutrophil].in present study, we have investigated superoxide (o2-) production from human neutrophils by recombinant human granulocyte colony-stimulating factor (g-csf) using the microtiter plate for the purpose of being close to the inflammatory site. g-csf by itself did not induce the release of o2- in human neutrophil on either fetal bovine serum (fbs)-coated plate or plate uncoated with fbs, even if neutrophils were exposed for maximum 3 hr. however, the optimal concentration of g-csf (50 ng/ml) was abl ...19901698209
rating of the lesions in senile dementia of the alzheimer type: concordance between laboratories. a european multicenter study under the auspices of eurage.the study reported was intended to compare the impressions and analyses of investigators from 11 different laboratories on 2 slides, each from 6 cases with varying quantities of neuropathological change of the type found in alzheimer's disease and normal ageing. the material came from 6 selected female patients over 75 years of age all of whom had been examined in detail and assessed by the blessed test score. two were severely demented, 2 mildly demented and 2 were considered to be normal. unst ...20061698217
conduction velocity distribution of afferent fibers innervating the rat urinary bladder.the conduction velocities of individual afferent fibers innervating the rat urinary bladder were determined by the antidromic stimulation of dorsal roots while recording from bladder postganglionic nerves. conduction velocities ranged from 0.5 to 21.0 m/s; 70% of the velocities were less than 2.5 m/s. the distribution within the dorsal roots was ipsilateral with 84% in l6 and 16% in s1. neuroanatomical tracing with horseradish peroxidase applied to individual bladder postganglionic nerves result ...19901698508
adhesion molecules (n-cam and tenascin) in embryonic development and tissue regeneration. 20061698808
intrageneric relationships of members of the genus fusobacterium as determined by reverse transcriptase sequencing of small-subunit rrna.the phylogenetic interrelationships of 14 members of the genus fusobacterium were investigated by performing a comparative analysis of the 16s rrna sequences of these organisms. the sequence data revealed considerable intrageneric heterogeneity. the four species fusobacterium nucleatum (including f. nucleatum subsp. nucleatum, f. nucleatum subsp. polymorphum, "f. nucleatum subsp. fusiforme," and "f. nucleatum subsp. animalis"), fusobacterium alocis, fusobacterium periodonticum, and fusobacterium ...19911715737
the association of occult amniotic fluid infection with gestational age and neonatal outcome among women in preterm labor.to evaluate the relationships between gestational age, neonatal outcome, and amniotic fluid (af) bacteria, we obtained af from women with intact membranes in idiopathic preterm labor. positive cultures were obtained from 20 (19%) of 105 women. the frequency of positive cultures was inversely related to gestational age: 23-26 weeks, nine of 20; 27-30 weeks, four of 24; and 31-34 weeks, seven of 61 (chi2 for trend, p less than .001). fusobacterium nucleatum, bacteroides ureolyticus, and ureaplasma ...19921738513
fusobacterium nucleatum pyomyositis. 19921738725
osteomyelitis of the pelvis due to fusobacterium nucleatum.anaerobic pelvic osteomyelitis occurs rarely in children. a case of fusobacterium nucleatum osteomyelitis of the right ilium [correction of ileum] in a child without apparent risk factors is described. this case emphasizes the value of diagnostic aspirates. therapy with a combination of intravenous and oral clindamycin led to successful resolution of the infection.19911747843
the microflora of periodontal sites showing active destructive progression.20 adult periodontitis (ap) subjects were examined every 2 to 4 months and microbiological samples were collected and cultured when 2 mm or more loss of attachment (active sites) was detected by 2 examiners. similar sites in which no progressive destruction was observed (control sites) also were sampled in the same subjects. by lambda-analysis, there was no statistically significant difference in floras of active (42 sites from 12 subjects) and control (36 sites from 12 subjects) sites or betwee ...19911752997
fluorescence immunoassay for detecting periodontal bacterial pathogens in plaque.a particle concentration fluorescence immunoassay has been modified into a bacterial concentration fluorescence immunoassay (bcfia) to rapidly detect periodontopathic bacteria in human plaque samples. the bcfia utilizes fluorescently tagged monoclonal antibodies (mabs) directed against the lipopolysaccharide of selected gram-negative plaque bacteria. microorganisms closely associated with periodontal disease that can be identified in plaque with the bcfia include porphyromonas gingivalis, bacter ...19911761686
acute myocardial infarction after blunt chest trauma in young people: need for prompt intervention.we describe four cases of acute myocardial infarction in young patients, secondary to blunt chest trauma. one case was treated with intracoronary thrombolysis and angioplasty, two cases received systemic thrombolysis, and the last one did not have any reperfusion therapy. the coronary angiograms of the left anterior descending artery showed thrombosis in two cases, coronary dissection in one case, and no morphological lesions in the other. we encourage the early performance of angiographic studi ...20061764738
analysis of high psa n-cam expression during mammalian spinal cord and peripheral nervous system development.using a monoclonal antibody that recognizes specifically a high polysialylated form of n-cam (high psa n-cam), the temporal and spatial expression of this molecule was studied in developing spinal cord and neural crest derivatives of mouse truncal region. temporal expression was analyzed on immunoblots of spinal cord and dorsal root ganglia (drgs) extracts microdissected at different developmental stages. analysis of the ratio of high psa n-cam to total n-cam indicated that sialylation and desia ...19911769342
isolation and identification of bacteria from subgingival plaque with low susceptibility to minocycline.twenty subgingival plaque samples from patients with chronic periodontitis were screened for the presence of three periodontal 'pathogens'--porphyromonas gingivalis, fusobacterium nucleatum and eikenella corrodens. nineteen of the samples were found to contain at least one of the three organisms and six samples contained all three. the subgingival plaque samples were cultured in the presence of various concentrations of minocycline, and those organisms which appeared to be least susceptible to t ...19911769945
minority student nurses' perceptions of their educational program. 20061773054
increased incidence of cervical cytological abnormalities in women with genital warts or contact with genital warts: a need for increased vigilance?to determine whether women who have a history of genital warts or whose sexual partners have such a history were more likely to have borderline or dyskaryotic cervical smears than other women.20041774050
differential protective activities of site specific lipoxygenase inhibitors in endotoxic shock and production of tumor necrosis factor.lipoxygenase inhibitors have been shown to exert beneficial effects in experimental models of endotoxin shock. in the present study it was found that lipoxygenase inhibitors prevented lps, but not tumor necrosis factor alpha (tnf alpha)-evoked leukopenia in mice. these inhibitors protected against endotoxin lethality but not against tnf alpha induced lethality. when the protective potency of the specific 5-lipoxygenase inhibitors (mk 886, cgs 81585) was tested in endotoxin-induced leukopenia and ...19911783470
[subgingival microflora in children of early childhood, school age and circumpuberty. the proportion and frequency of gram-negative bacteria in periodontally healthy and gingivitis groups].the present study characterized the microbial profiles of the gingival sulci in children. subgingival samples from 36 gingivitis lesions of 18 patients and 36 sites in 18 healthy persons were examined. the tested individuals were divided into three stages according to physiological maturation i.e. early childhood, school age, circumpuberty. puberty was confirmed through examination of wrist radiographs. using continuous anaerobic techniques, samples were dispersed, diluted and then inoculated on ...19911784868
infection and infectious diseases. 20061796972
infection and infectious diseases. 20061796972
[nsf's elected representative to elite series. interview by bjørn arild ostby]. 20061797065
comparative in vitro activity of cefpodoxime against anaerobes other than bacteroides fragilis.to assess the in vitro activity of cefpodoxime against anaerobic respiratory tract and oropharyngeal pathogens 77 strains belonging to 18 gram-negative and 7 gram-positive species were studied by means of agar dilution tests. for comparison cefuroxime, amoxicillin, amoxicillin + clavulanic acid and clindamycin were also tested. cefpodoxime was found to be active at concentrations of less than or equal to 0.125 mg/l against prevotella oralis, prevotella buccalis, prevotella bivia, porphyromonas a ...19911800380
[a case of idiopathic aseptic osteonecrosis of the patellae: repeat study of tc-99m hmdp bone scintigraphy in a reparative phase].a 37-year-old woman entered our hospital because of bilateral knee pain. tc-99m hmdp bone scintigram demonstrated increased activity in the bilateral patellae and cold lesion in the center and left lateral segments of the left patellae, so-called doughnut pattern. trephine biopsy was performed to prove bilateral idiopathic asepct osteonecrosis of the patellae. the knee pain subsided and a bone scan 5 months later demonstrated increased activity in the bilateral patellae more widely than initial ...20061800777
[a case of idiopathic aseptic osteonecrosis of the patellae: repeat study of tc-99m hmdp bone scintigraphy in a reparative phase].a 37-year-old woman entered our hospital because of bilateral knee pain. tc-99m hmdp bone scintigram demonstrated increased activity in the bilateral patellae and cold lesion in the center and left lateral segments of the left patellae, so-called doughnut pattern. trephine biopsy was performed to prove bilateral idiopathic asepct osteonecrosis of the patellae. the knee pain subsided and a bone scan 5 months later demonstrated increased activity in the bilateral patellae more widely than initial ...20061800777
cluster headache. our current concepts.cluster headache and chronic paroxysmal hemicrania are assumed to be so closely related that they from a classification point of view have been grouped together under the superstructure: cluster headache syndrome. if this grouping will prove to stand the test of time, the pathogenesis of the two subgroups ought to be quite similar. cph per se has two subgroups: those with and those without mechanical precipitation of attacks. if the aforementioned grouping of cph is correct, then the cph subdivi ...20071805550
radiosurgical treatment of cerebral metastases. method, indications and results.stereotactically guided single-dose irradiation of brain metastases with low radiosensitivity has been performed in a series of 30 patients. clinical symptoms improved in 18 of 27 evaluated patients and remained stable in another 7. tumour regression was achieved in 13 of 22 patients, and arrest of tumour growth in 7 other patients. the treatment was usually well tolerated. the incidence of side effects was low. thus, radiosurgery seems to be a valuable alternative to microsurgical extirpation o ...20031808657
bacteria in the apical 5 mm of infected root canals.ten freshly extracted teeth which had carious pulpal exposures and periapical lesions contiguous with the root apex were placed inside an anaerobic chamber and the apical 5 mm of the root canals cultured. in addition to anaerobic incubation, duplicate cultures were incubated aerobically. fifty strains of bacteria from the 10 root canals were isolated and identified. the most prominent bacteria cultured from the 10 root canals were actinomyces, lactobacillus, black-pigmented bacteroides, peptostr ...19911809801
[the dynamic modification of aseptic inflammation with sodium oxybutyrate].the oxybuturate sodium influence on the vessel and cells dynamics in the source of aseptic inflammation was studied. it was shown that oxybuturate sodium injection (100 mg/kg) before 30 min and after 2 and 4 hours of inflammation onset leads to suppression of microvessel reaction, reduction of macrophagic infiltrate density, decrease of macrophagic phase duration and the earliest perfection of inflammation in the whole.19911810478
adherence to experimental pellicle of rough-type lipopolysaccharides from subgingival plaque bacteria.the adherence of lipopolysaccharides (lpss) from periodontal disease-associated bacteria to saliva-coated hydroxyapatite (s-ha) and serum-coated ha beads was examined by chromogenic limulus activity (toxicolor test). phenol-water extracted lps preparations from bacteroides intermedius, fusobacterium nucleatum, actinobacillus actinomycetemcomitans, eikenella corrodens, and rough-type lps from escherichia coli adhered to s-ha and serum-coated beads and agglutinated human erythrocytes. the adhered ...19911812466
aspects of the growth and metabolism of fusobacterium nucleatum atcc 10953 in continuous culture.fusobacterium nucleatum atcc 10953, a type strain of one of the newly proposed subspecies of this group of organisms, was grown anaerobically in continuous culture in a chemically defined medium. its response to conditions of varying ph, nutritional environment, and imposed growth rate were then examined. the organism failed to grow at ph 7.8 but grew at ph 5.8, although the cell yield was greatly reduced. at ph 6.8 the cell yield was halved and less than 50% of available glucose was consumed. t ...19911812468
antimicrobial activity of flurbiprofen and ibuprofen in vitro against six common periodontal pathogens.nonsteroidal antiinflammatory drugs (nsaids) such as flurbiprofen and ibuprofen, have been shown to inhibit the inflammation and alveolar bone loss associated with chronic destructive periodontal disease. however, the direct effect of nsaids on the gingival crevice microflora has not been studied. the purpose of this investigation was to evaluate the antimicrobial activity of ibuprofen and flurbiprofen in vitro on six commonly isolated periodontal pathogens. the bacterial strains evaluated were ...19911812907
[effect of the type of swab on the isolation of chlamydia trachomatis].the success in the isolation of c. trachomatis is dependent on several factors. one of them is the type of swab used for collection the specimens. as some types of swabs, such as calcium alginate and aluminum, cotton and wood have recently been shown to decrease the isolation rate, different types of swabs were prepared and tested in our laboratory. commercial aluminum, type 5056 aluminum and stainless steel were used with the same type of cotton. commercial swabs of cotton and wood were tested ...19911815280
formation of nitrogen-containing metabolites from geniposide and gardenoside by human intestinal bacteria.during the course of our studies on the metabolism of iridoid glycosides by human intestinal bacteria, we found that geniposide (1) and gardenoside (4) were transformed to new nitrogen-containing compounds, genipinine (3) and gardenine (6), respectively, along with the known aglycones. although the amounts of new metabolites were somewhat lower than those of the aglycones, they were quantitatively analyzed by means of liquid chromatography/mass spectrometry (lc/ms). of 25 strains of human intest ...19911818345
a heat stable hemagglutinating activity of eikenella corrodens.strains of eikenella corrodens and fusobacterium nucleatum were shown to possess lectinlike attachment factors. the present investigators found that e. corrodens has a heat stable factor which agglutinates sheep, mouse, and human erythrocytes. the activity is not abolished by additions of galactose or lactose. lipopolysaccharide preparations from e. corrodens strains possessed strong hemagglutinating activity. lpss of f. nucleatum did not agglutinate any erythrocytes tested. sds-page patterns st ...19911819444
adhesive properties of strains of fusobacterium nucleatum of the subspecies nucleatum, vincentii and polymorphum.this study surveyed some adhesive properties of strains of fusobacterium nucleatum representative of the 3 recently defined groups or subspecies that could relate to their colonization and virulence. with one exception, f. nucleatum strains agglutinated sheep erythrocytes, but the quantity of bacteria required and the sensitivity of the hemagglutination reactions to inhibition by 0.05 m galactose or arginine varied between strains, and did not exhibit clear-cut correlations with subspecies. neur ...19911820561
comparison of the amino acid uptake profile of reference and clinical isolates of fusobacterium nucleatum subspecies.human isolates of fusobacterium nucleatum subspecies appear to colonize different niches in the oral cavity, which may be reflected in their nutritional properties. consequently the utilization of nitrogenous substrates, their sources of energy (supplied here as amino acids) were compared between the 3 subspecies using the reference strain and fresh clinical isolates of each subspecies. all strains incorporated mainly acidic and basic amino acids but significant differences occurred between subs ...19911820562
predominant cultivable flora in pericoronitis.the predominant cultivable flora in pericoronitis was investigated by culturing pus from affected sites in 20 patients. twenty colonies were picked at random from non-selective plates and identified using conventional biochemical and physiological tests, analysis of metabolic end-products by gas chromatography and protein profile analysis. the most frequently isolated organisms were prevotella (bacteroides) intermedia, peptostreptococcus micros, veillonella species, fusobacterium nucleatum and s ...19911820571
tropisetron plus haloperidol to ameliorate nausea and vomiting associated with high-dose alkylating agent cancer chemotherapy.tropisetron is a novel antiserotoninergic drug with potent and specific activity against cancer chemotherapy-induced emesis. high-dose cyclophosphamide or high-dose melphalan are chemotherapeutic regimens associated with severe nausea and vomiting refractory to current antiemetic medications. we compared in a randomised open label study the antiemetic efficacy of tropisetron and alizapride in a first group of 32 consecutive patients treated with high-dose alkylating agent chemotherapy with or wi ...20061828962
tropisetron plus haloperidol to ameliorate nausea and vomiting associated with high-dose alkylating agent cancer chemotherapy.tropisetron is a novel antiserotoninergic drug with potent and specific activity against cancer chemotherapy-induced emesis. high-dose cyclophosphamide or high-dose melphalan are chemotherapeutic regimens associated with severe nausea and vomiting refractory to current antiemetic medications. we compared in a randomised open label study the antiemetic efficacy of tropisetron and alizapride in a first group of 32 consecutive patients treated with high-dose alkylating agent chemotherapy with or wi ...20061828962
identification of components in fusobacterium nucleatum chemostat-culture supernatants that are potent inhibitors of human gingival fibroblast proliferation.the present investigation concerned the effect of chemostat-culture cell-free supernatants of fusobacterium nucleatum on the growth and synthetic activity of human gingival fibroblasts in vitro. human gingival fibroblasts were cultured in fetal calf serum supplemented dulbecco-vogt medium containing various dilutions of conditioned or unconditioned bacterial culture medium. cell proliferation was monitored by assessing cell growth over 5 days or incorporation of [3h]-thymidine into dna. protein ...19911831499
multicenter evaluation of tetracycline fiber therapy. iii. microbiological response.in a multicenter study of the effects of tetracycline (tc) fiber therapy, subgingival plaque samples were tested for 6 probable periodontal pathogens by dna probe analysis. levels of actinobacillus actinomycetemcomitans, eikenella corrodens, fusobacterium nucleatum, porphyromonas (bacteroides) gingivalis, prevotella intermedia (bacteroides intermedius), and wolinella recta were quantitatively determined in samples taken at baseline, and immediately after tc fiber removal, control fiber removal, ...19911832457
tetracycline fiber therapy monitored by dna probe and cultural methods.oligonucleotide dna probe and selective cultural methods were compared in their ability to monitor 6 putative periodontal pathogens in a study evaluating local tetracycline fiber therapy. subgingival plaque was sampled from 4 sites in each of 20 subjects. samples were taken before and after therapy from sites assigned to the following test groups: tetracycline (tc) fiber, scaling and root planing, control fiber, and untreated. each sample was analyzed by both dna probe and cultural methods. tota ...19911832458
use of synthetic oligonucleotide dna probes for the identification of different strains of fusobacterium nucleatum.the ability of three different oligonucleotide probes to identify different oral strains of fusobacterium nucleatum was tested. probes 119 and 214 were designed on the basis of known amino acid sequences from the n-terminal end of an outer membrane protein of f. nucleatum strain fev1. probe h 2.1, was a randomly cloned chromosomal dna fragment of 2.1 kbp. the specificities of the probes were examined by testing each of them against a panel of five other species of fusobacterium (six strains), or ...19911837056
[lifestyle and reproductive situations of adolescent girls in large cities].an analysis is made of a sociological interview survey of teenage girls residing and attending educational establishments in one of the moscow regions. teenage girls' views on some issues of future family life have been identified. it has been found that there is a wide prevalence of harmful habits among these populations, the majority of girls have a sexual experience along with low culture of sexual behavior and healthy lifestyle habits.20071838436
regulation of alcohol consumption by the renin-angiotensin system: a review of recent findings and a possible mechanism of action.the renin-angiotensin system has traditionally been associated with the regulation of fluid and electrolyte balance. in this review we summarize the data which ascribes a completely new function to this system, i.e., the regulation of alcohol consumption. in addition, we suggest a possible mechanism for this effect based on the concept of a satiety or stop process. the approach taken was to examine the effect on alcohol intake of a wide variety of drug, genetic, dietary, surgical and neurosurgic ...20071852316
response by dr. alden n. haffner upon receipt of the koch memorial medal 1990. 20071852404
body mass index variations: centiles from birth to 87 years.this report provides body mass index (weight/height2) values for the french population from birth to the age of 87 years. bmi curves increase during the first year, decrease until the age of 6, increase again up to 65 years and decrease thereafter. these variations reflect the total changes of fat body mass during life. the 50th centile values of wt/ht2 at the ages of 20, 40, 60, 80 years are 21.5, 24.6, 25.4, 24.4 kg/m2 for men and 20.6, 22.6, 24.1, 23.4 kg/m2 for women. the values for the 3rd, ...20071855495
neurons of the pretectal area convey spinal input to the motor thalamus of the cat.the aim of this study was to corroborate lesioning work (mackel and noda 1989), suggesting the pretectal area of the rostral midbrain acts as a relay between the spinal cord and the ventrolateral (vl) nucleus of the thalamus. for this purpose, extracellular recordings were made from neurons in the pretectal area which were antidromically activated by stimulation in the rostral thalamus, particularly in vl. the neurons were tested for input from the dorsal columns of the spinal cord, the dorsal c ...19911855554
endogenous n-nitrosation and cancer of the biliary tract.evidence is presented that n-nitroso compounds occur in bile from patients who have undergone surgery for gallstones or had gastrectomy and from unoperated persons. it is unlikely, therefore, that local formation of nitrosamines can account for the excess risk for gallbladder cancer in the first two groups. gastric formation remains the likeliest hypothesis.20071855836
prostaglandin production by amnion and decidual cells in response to bacterial products.media from bacterial cultures have been tested for actions on prostaglandin biosynthesis by human amnion and decidual cells. the bacterial species, which are commonly associated with intrauterine infections, were group b streptococcus, escherichia coli, fusobacterium nucleatum, bacteroides fragilis, gardnerella vaginalis, neisseria gonorrhea, mycoplasma hominis and ureaplasma urealyticum. overall, low doses of bacterial products were stimulatory of amnion prostaglandin production, whereas high d ...19911857723
bacterial flora of the uterus of cows after calving on two hygienically contrasting farms.intrauterine swabs were obtained from cows after calving on two commercial dairy herds with contrasting hygienic environments and incidence of leucorrhea, and cultured aerobically and anaerobically. of 26 cows with a normal calving and puerperium, eight of 14 (57 per cent) were sterile on farm b where hygiene was poor, compared with five of 12 (42 per cent) on farm a where hygiene was better. two cows on farm b retained their placentas and subsequently developed metritis/endometritis. actinomyce ...19911858270
[observations on the intraocular pressure after extracapsular cataract extraction].the author observed the iop of 32 eyes after extracapsular cataract extraction with posterior chamber intraocular lens implantation. the iop was elevated in all cases, over 0.67 kpa (5 mmhg) in 22 cases, over 1.33 kpa (10 mmhg) in 12 cases, and the highest was 5.05 kpa (38 mmhg). the peak of elevation was at 24 hours after operation and most cases resumed the preoperative levels in 48 hours. the iop of eyes with intracameral carbachol was significantly lower than that of those without at 6 hours ...20061860411
[lobac caused a life-threatening burn-like skin injury]. 20071865722
singular neurectomy update. ii. review of 102 cases.during the past 18 years, 102 singular neurectomies (sn) were performed on 95 patients with chronic cupulolithiasis of the posterior canal sense organ. bilateral sequential singular neurectomies were performed in 7 patients and unilateral singular neurectomies in 88 patients. ninety-nine (97%) of the 102 singular neurectomies completely eliminated the positional nystagmus and vertigo produced by the involved (undermost) ear in the hallpike maneuver. following three singular neurectomies (3%), th ...20071865734
in the aftermath: health care in kuwait city. 20071865865
[conservative management of lymphedema of the limbs].etiology and stadium of 63 lymphoedema patients are shown. the method of lymph-drainage therapy is discussed. important part of this treatment is bandaging. lymphamat pump (bösl) was successfully used as a part of the therapy. according to the good experiences it seems to be adviceable to use this method for treatment of limb lymphoedema. this method was successful in diuretics, venoruton, doxium and lymph-compress resistant cases.20061866167
effects and aftereffects of ibogaine on morphine self-administration in rats.ibogaine, a naturally occurring alkaloid, has been claimed to be effective in treating addition to opiate and stimulant drugs. as a preclinical test of this claim, the present study sought to determine if ibogaine would reduce the intravenous self-administration of morphine in rats. ibogaine dose dependently (2.5-80 mg/kg) decreased morphine intake in the hour after ibogaine treatment (acute effect) and, to a lesser extent, a day later (aftereffect); while the acute effect could be attributed to ...19911868880
a study of the antigenic composition of the fragilis group of bacteroides.representative strains of 22 serotypes of the fragilis group of bacteroides and four non-fragilis control strains of b. melaninogenicus, b. disiens, b. bivius and fusobacterium nucleatum were tested by sds-page and immunoblotting with hyperimmune rabbit sera. sds-page showed 25 polypeptide bands but, after immunoblotting, 24 antigenic bands were observed in various combinations in all the strains. three of these were detected only in the control strains, whereas six others were present in differ ...19911875392
isolation, purification and characterisation of 2-oxoglutarate reductase from fusobacterium nucleatum.2-oxoglutarate reductase from fusobacterium nucleatum was isolated by thiol-disulphide interchange covalent chromatography. the enzyme was purified approximately 4000-fold and had a molecular mass of 68 kda. the michaelis constants for 2-oxoglutarate and nadh were 6.4 x 10(-5) and 0.4 x 10(-5), respectively. the involvement of sulphahydryl groups in catalysis was shown from the inhibition of 2-oxoglutarate reduction in the presence of 2,2'-dipyridyl disulphide and reactivation with 2-mercaptoeth ...19911884985
the use of genomic dna fingerprinting in studies of the epidemiology of bacteria in periodontitis.recent studies of microbial epidemiology emphasizing the genetic organization and distribution of organisms associated with orofacial infections have led to new insights into the possible origins of pathogenicity. studies into genetic heterogeneity, acquisition and transmission of these organisms have been markedly advanced by the utilization of the powerful technique of genomic dna fingerprinting. characteristic fingerprints for each bacterial isolate can be produced by cleavage of high molecul ...19911890219
dental bacterial plaques. nature and role in periodontal disease.antony van leeuwenhoek first described oral bacteria. however, not until almost 200 years later was the famous koch postulate introduced. since then, research has extensively been performed regarding the development and microbiology of dental plaques. in spite of the complexity of the developing flora of supragingival plaque, culture studies have shown a remarkably orderly succession of organisms. lately, the concept of microbial specificity in the etiology of periodontal diseases has been widel ...19911890226
structure and bacterial receptor activity of a human salivary proline-rich glycoprotein.using an overlay technique, we previously showed that the gram-negative periodontal pathogen fusobacterium nucleatum binds to a glycoprotein of mr 89,000 (prakobphol, a., murray, p., and fischer, s.j. (1987) anal. biochem. 164, 5-11) in the parotid saliva of some individuals. we now show that deglycosylation of the purified glycoprotein results in loss of receptor activity. amino acid analysis of the protein core showed predominantly proline, glycine, and glutamic acid/glutamine, a characteristi ...19911894623
modeling bacterial damage to pulpal cells in vitro.there is increasing evidence that access to patent dentinal tubules by bacteria and their products rather than trauma from restorative materials is responsible for subsequent pulpitides. the purpose of this study was to compare the relative cytotoxicity of centrifugal fractions of two bacteria, fusobacterium nucleatum and treponema denticola, on l929 cells in monolayer cultures and in the "in vitro pulp chamber." neutrophilic chemotaxis assays and limmulus assays were performed to verify biologi ...19911895035
patterns of plasma sex hormone-binding globulin, thyroxine and thyroxine-binding globulin in relation to reproductive state and hibernation in female little brown bats.a sex hormone-binding globulin (shbg), which bound both oestradiol and dihydrotestosterone, was studied in the plasma of adult female little brown bats throughout the annual reproductive cycle. this protein was present at low baseline levels from september to may inclusive, months which correspond to the periods of hibernation, ovulation and early pregnancy. during the second half of pregnancy in june, shbg levels increased 15- to 30-fold and remained increased throughout lactation and anoestrus ...19911900322
identification, and susceptibility to seven antimicrobial agents, of 61 gram-negative anaerobic rods from periodontal pockets.sixty-one cultures of gram-negative anaerobic rods were isolated from deep periodontal pockets of patients with rapidly progressive periodontitis. isolates were speciated as bacteroides gingivalis (18 isolates), bacteroides intermedius (8), bacteroides oris (1), bacteroides gracilis (17) and fusobacterium nucleatum (17). their susceptibilities, to seven antimicrobial agents, were determined in vitro using a plate dilution technique. amoxycillin and amoxycillin with clavulanic acid were active ag ...19911901873
purification and characterization of 3-hydroxymethylglutaryl-coenzyme a reductase of schistosoma mansoni: regulation of parasite enzyme activity differs from mammalian host.the enzyme 3-hydroxymethylglutaryl-coa (hmg-coa) reductase plays a critical role in regulating the production of cholesterol, dolichols, and ubiquinones in mammals. the inhibition of this enzyme in schistosoma mansoni is accompanied by a cessation of egg production by the female parasite and a reduced ability of the parasite to properly glycoslyate their proteins. furthermore, we recently demonstrated that mevinolin, if given continuously over a period of 10-14 days, is a potent antischistosomal ...19911905241
compensatory increase in lactase expression by enterocytes of neonatal pigs on a low energy intake.a restricted energy intake in the immediate postnatal period has been found to result in a significant increase in the maximal expression of lactase by enterocytes from 2-week-old pigs. although villus size was significantly reduced on a low compared with a high food intake, total villus lactase activity was unaffected because of the compensatory increase in lactase expression by individual enterocytes.19911905556
biological functions of the water-insoluble fraction of mouse seminal vesicle fluid. i. suppression of the blastogenic response of lymphocytes.the effects of the water-insoluble fraction of mouse seminal vesicle fluid (wif-svf) on lymphocytes was investigated to clarify its role in reproductive immunity. wif-svf inhibited the blastogenic response of t-cells to concanavalin-a (con-a), but it did not inhibit the blastogenic response of b-cells to lipopolysaccharide (lps). pretreatment of splenocytes with wif-svf did not suppress the blastogenic response of splenocytes to con-a when treated cells were washed prior to culture. wif-svf did ...19911906049
leukemia inhibitory factor: does the cap fit? 19911906256
gtp-binding membrane proteins in activated and differentiating t cells.we have earlier reported changes in the gtp binding of several membrane proteins including gs alpha and gi alpha during thymic differentiation of t cells. using an [alpha-32p]gtp-photoaffinity labeling technique we have studied the pattern of gtp binding proteins in activated and resting t lymphocytes and in t cells induced to differentiate by tpa. the gtp binding proteins in mitogen-activated t cells resembled those seen in leukemia t cell lines. treatment of jurkat, but not of ccrf-cem, t cell ...20021906270
neuropeptide-y innervation of the rat spleen: another potential immunomodulatory neuropeptide.neuropeptide-y (npy) is a 36 amino acid peptide that acts as a chemical messenger in the central and peripheral nervous systems. npy often is found colocalized with the classical neurotransmitter norepinephrine (ne) and can potentiate the effects of this neurotransmitter postsynaptically in many systems. using immunocytochemistry for npy and specific lymphoid cell markers, we mapped the distribution of npy-positive nerve fibers in the rat spleen. npy-positive nerve fibers were present along the ...19911906353
changes in the t-lymphocyte subpopulation (cd+/cd8+) in the blood of patients following kidney transplant and during the acute rejection episode.a study was made of changes in the ratio of cd4+/cd8+ in patients who had received cadaverous kidneys and who were under treatment with a combination of cyclosporin a + azathioprine + cor ticosteroids. the results showed that one month after the transparent there was a significant drop (p less than 0.05) in the immunoregulation index compared with the pretransplantation values. throughout the whole period a correlation (r = -0.65, p less than 0.05) was found between the cd4+/cd8+ ratio and serum ...20021906396
experience with sperm counts following vasectomy.the records of aberdeen men requesting vasectomy between 1978 and 1981 were studied and a sample of men were interviewed about 3 years after the operation; 85% completed the standard requirements for seminal analysis and were given the "all clear"; two-thirds were cleared after sending 2 samples and usually within 20 weeks after vasectomy; 10% of men sent at least 1 sample but were never cleared and the remaining 5% ignored the requirements. information from 70 men (63 interviews, 7 questionnair ...20071913061
new prosthetic venous collar anastomotic technique: combining the best of other procedures. 20071913097
protein-kinase-c-independent activation of arachidonate release and prostaglandin e2 formation in macrophages interacting with certain bacteria.certain bacterial species, of which we selected fusobacterium nucleatum, gardnerella vaginalis, peptostreptococcus anaerobius and propionibacterium acnes, were found to induce release of arachidonic acid in a dose- and time-dependent manner in mouse macrophages. the release of arachidonic acid showed a characteristic lag period of approximately 10 min and was accompanied by selective transformation into prostaglandin e2. bacteria killed by various methods caused a similar response, indicating th ...19911915341
isolation and purification of bacteriocin from prevotella intermedia (bacteroides intermedius).thirty-three out of 46 strains of prevotella intermedia (bacteroides intermedius) isolated from gingival deposits of patients with adult periodontitis possessed the ability to inhibit growth of p. intermedia strain atcc 25611, and 6 of the 33 showed strong inhibitory activity. thirteen isolates did not have the ability to inhibit the growth of p. intermedia strain atcc 25611. an inhibition factor from one of the isolates, p. intermedia th14 which had strong inhibition, was purified and character ...19911920011
control of enterococcus faecalis sex pheromone cad1 elaboration: effects of culture aeration and pad1 plasmid-encoded determinants.aeration of plasmid-free enterococcus faecalis strains resulted in an 8- to 16-fold decrease in sex pheromone cad1 activity in culture filtrates. levels of two unrelated pheromones, cpd1 and cam373, were unaffected by culture aeration. aeration also resulted in a decrease in the expression of conjugative transfer functions observed in cells containing pad1 trab mutations, verifying a link between trab function and pheromone "shutdown." tests with a series of pad1 mini-plasmids indicated that the ...19911924555
observation and theory in psychoanalysis: the self psychology of heinz kohut.the development of self psychology by heinz kohut illustrates the influence of observational method on theory formation in psychoanalysis. in 1959 kohut began to emphasize empathy and introspection over the traditional combination of free association and evenly suspended attention. this became an important part of a process of revision in psychoanalytic theory which culminated in self psychology. this paper demonstrates how and why that particular change in observational method influenced that p ...20071924603
[clinical evaluation of 70 pediatric renal transplants after 10 to 17 years].among 149 kidneys transplanted in 141 children and teenagers aged 4 1/2 to 20 years, from november 1972 through december 1979, 70 (47%) were still functioning after ten years (67/145 cadaver donor grafts and 3/4 living related donor grafts). medical and social status at the last follow-up visit (10 to 16 1/2 years after transplantation; m = 12 years) was analyzed. patients were divided into five groups on the basis of glomerular filtration rate (gfr; ml/min/1.73 m2) and blood pressure (bp): 1) g ...20071929108
tetracycline resistance in peptostreptococcus species.of 15 peptostreptococcus sp. strains isolated between 1975 and 1984, 13 hybridized with the tet k, tet m, or tet o determinant. a donor peptostreptococcus anaerobius strain carrying the three determinants could transfer tet m to p. anaerobius and fusobacterium nucleatum recipients but not to an enterococcus faecalis recipient, while neither tet k nor tet o was transferred.19911929341
alcoholic liver disease in japanese patients: a comparison with caucasians. 20071932673
counsel and care. 20071933094
accumulation of plasma cells in inflamed sites: effects of antigen, nonspecific microbial activators, and chronic inflammation.plasma cells are common in chronically inflamed sites, including periodontal lesions. the aim of this study was to determine which factors contribute to this local accumulation of plasma cells. specifically, we sought to evaluate the effects of specific antigen and nonspecific activators from an infectious agent associated with chronic inflammation (fusobacterium nucleatum, an organism prominent in chronic periodontal lesions) and the effect of the chronic inflammation itself. chronic inflammati ...19911937760
architectonics of the parietal and temporal association cortex in the strepsirhine primate galago compared to the anthropoid primate macaca.a number of higher order association areas have been described in the parietal and temporal cortex of large-brained anthropoid primates such as macaca. however, little is known about the evolution of these areas, and the existence of homologous areas has not yet been clearly demonstrated in other mammalian groups. we addressed this issue by comparing the myelo- and cytoarchitecture of posterior association cortex in the anthropoid macaca to that of the small-brained, strepsirhine ("prosimian") p ...20071939733
reactivity of igg from explant cultures of periapical lesions with implicated microorganisms.the presence of igg in periapical inflammatory lesions suggests that immune responses participate in the disease process. the purpose of this investigation was to study the reactivity of igg from the supernatant fluids of explant cultures of periapical lesions with microorganisms implicated in infections of endodontic origin. ninety periapical lesions that had been contiguous with the apex of a root were removed and maintained in explant cultures. a dot-enzyme-linked immunosorbent assay (dot-eli ...19911940739
specificity of antibodies present in human periapical lesions.various classes of immunoglobulins have been found in human periapical lesions. the specificity of secreted antibodies against antigens egressing from the root canal system has yet to be thoroughly investigated. the purpose of this study was to test the specificity of antibodies present in human periapical lesions. human periapical biopsies were removed and cultured as organ culture explants. antibodies present in the lesions were extracted in the cell culture fluids. a modified enzyme-linked im ...19911940740
preliminary investigation of crystals of the neutral lipase from pseudomonas fluorescens.the neutral lipase from the bacteria pseudomonas fluorescens, marketed under the trade name lpl-200s, has been crystallized in a form suitable for x-ray diffraction analysis from 35% n-propanol at ph 8.5. the crystals are monoclinic prisms and are of space group c2 with a = 91.00 a, b = 47.17 a, c = 35.21 a and beta = 121.43 degrees. there is one molecule of the protein as the asymmetric unit of the crystals. the diffraction pattern extends to at least 1.6 a resolution and the crystals are extre ...19911942065
dna probe detection of eikenella corrodens, wolinella recta and fusobacterium nucleatum in subgingival plaque.this cross-sectional study used species-specific dna probes to examine subgingival plaque specimens for the presence of eikenella corrodens, wolinella recta, and fusobacterium nucleatum in adults with untreated periodontitis or gingivitis and in healthy controls. w. recta and f. nucleatum were more prevalent in diseased sites from the periodontitis group when compared with the controls (81% vs 22% and 83% vs 20% respectively). e. corrodens was detected in 62% of the control sites and 81% of the ...19911945492
seventh international meeting of the society for advancement of contraception. singapore, 4-11 november 1990. 20071950709
propionate lowers blood glucose and alters lipid metabolism in healthy subjects.incorporation of 3.3 g sodium propionate per 50 g available carbohydrate portion of bread reduced acutely the blood glucose response area in six healthy volunteers by 47.6 +/- 12.1% similarly, in vitro digestibility was reduced by 47.4 +/- 1.1% (p less than 0.01). one week of dietary supplementation with 9.9 g sodium propionate in bread/d reduced the blood glucose area in comparison with standard propionate-free bread by 38.0 +/- 8.7% (p less than 0.05), but increased fecal bulk by 28.3 +/- 8.7% ...20071951157
dental trauma during entonox inhalation via mouthpiece. 20071952018
[ecosystem of microbial flora in periodontal pockets, in vitro].this study was designed to analyze the succession of an ecosystem of microbial flora in periodontal pockets, in vitro. bacterial strains used in this study, were fusobacterium nucleatum atcc 10953, porphyromonas gingivalis 381, streptococcus sanguis atcc 10557 and streptococcus mutans omz 176. the bacterial cells, associated with beneficial, pathogenic or plaque forming activity, were cultured in brain heart infusion medium including hemin, vitamin-k1, l-cysteine hydrochloride and sodium thiogly ...19901966733
peptidoglycan precursor from fusobacterium nucleatum contains lanthionine.fusobacterium nucleatum was grown in the presence of [14c]udp. by means of sequential precipitation and chromatographic separation of the cytoplasmic content, a peptidoglycan [14c]udp pentapeptide containing lanthionine was isolated. this finding indicates that lanthionine is synthesized and incorporated as such during the assembly of the peptidoglycan.19911987169
microbiological and immunological aspects of experimental periodontal disease in rats: a review article.animal models in which microbiological and immunological aspects of periodontal disease can be studied prospectively seem well warranted. the rat bears much resemblance to man with respect to periodontal anatomy, development and composition of dental plaque, histopathology of periodontal lesions, and basic immunobiology. furthermore, reproducible methods are available for assessment of periodontal disease in rats, and detectable periodontal destruction can be induced in a few weeks in these anim ...19912002433
the helicobacter (campylobacter) pylori-colonized duodenal mucosa and gastric metaplasia.biopsies were obtained from non-ulcerated sites of the duodenum from 100 dyspeptic patients. helicobacter (campylobacter) pylori was cultivated from 19 of these biopsies. active chronic duodenitis (acd) was found in 17 biopsies and more than 5% gastric metaplasia in 20 biopsies. h. pylori as well as acd occurred with a significantly increased frequency when more than 5% gastric metaplasia was found in the duodenal biopsies. h. pylori on metaplastic tissue without acd was, however, seen in two ca ...19912018637
validation of biologic markers for use in research on chronic fatigue syndrome.unresolved aspects of chronic fatigue syndrome can be addressed by research involving biologic markers. these may be any molecular, biochemical, physiological, or other biologic parameter obtainable from biologic specimens. the use of biologic markers in research requires their validation as dependent or independent variables. additionally, other characteristics of markers such as reliability of assays, background level, confounding factors, interpretations, and legal and ethical implications sh ...20072020808
a randomized, placebo-controlled trial of doxycycline: effect on the microflora of recurrent periodontitis lesions in high risk patients.twenty-seven patients with a recent history of periodontal abscesses and/or loss of gingival attachment level (gal) despite active periodontal therapy were enrolled in a double-blind, randomized, placebo-controlled trial. clinical measurements and subgingival scaling were performed every 2 months. when a site exhibited greater than or equal to 2 mm loss of gal or a periodontal abscess, patients were administered either doxycycline at a dosage of 200 mg to start and 100 mg per day for 3 weeks, or ...19912027071
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