Publications

nerve sheath myxoma: an immunohistochemical study of a case.		2006	1489420
expression of small heat shock proteins by the third-stage larva of brugia pahangi.	changes in proteins synthesised by the infective third-stage larvae (l3) of the filarial nematode brugia pahangi were examined with respect to the temperature shift encountered by the parasite as it migrates from insect to mammal, and the presence of serum in the culture medium. while the synthesis of a number of polypeptides is regulated by the temperature shift of the l3 from 28 degrees c to 37 degrees c in vitro, there is no evidence that serum has any significant effect on protein synthesis. ...	1992	1484547
susceptibility of anaerobic microorganisms to hypothiocyanite produced by lactoperoxidase.	the susceptibility of capnocytophaga ochracea, eikenella corrodens, eubacterium yurii, fusobacterium nucleatum, peptostreptococcus micros, prevotella intermedia, selenomonas sputigena, wolinella recta to hypothiocyanite (oscn-) produced by the lactoperoxidase system was tested. results showed a decrease of bacterial survival rate after oscn- exposure, with an intra- and inter-species variability from 0 to 95% for c. ochracea, 34-100% for e. corrodens, 0-83% for e. yurii, 1-15% for f. nucleatum, ...	1992	1481764
[pneumococcus-induced septicemia in normal and splenectomized rabbits].	a new rabbit model to study the consequences of splenectomy in host resistance to induced pneumococcal septicaemia is presented. a simple, fast, non-invasive and complication-free technique of bacterial inoculation into the rabbit airways, using transcutaneous cannulation of the trachea, is also described. sixteen normal and 24 splenectomised animals were used. the optimal dose of pneumonococcus (serotype b, type iii) was found to be 1 x 10(7) organisms. the above dose of bacteria given transtra ...	1992	1479858
hiv education and health education in the united states: a national survey of local school district policies and practices.	to determine the extent to which hiv education and health education policies and practices are required by school districts in the united states, a national probability sample of public school districts was surveyed by mail in 1990. of 2,150 districts selected, 78.1% responded. hiv education was required by 66.9% of districts. of these, the percentage requiring hiv education increased by grade level from 29.7% in kindergarten to 82.3% in 7th grade, then declined to 37.3% by 12th grade. districts ...	1992	1479838
milk--a better drink? relationships with total serum cholesterol in a cross-sectional survey. the nordland health study.	cross-sectional studies have not consistently shown a positive association between milk drinking and serum cholesterol. we studied this relationship in a cohort of 7506 men and women aged 40-42 years in the county of nordland in northern norway (72% of all subjects in the age-bracket living in the county). we found a positive relationship between the percentage of fat in the milk and total serum cholesterol, but no positive relationship between whole fat milk consumption (number of glasses per d ...	2006	1475646
rat sertoli and spermatogenic cells express a similar gene, and its product is antigenically related to an outer dense fiber-associated protein.	we have previously reported that a heterodimeric protein secreted by rat sertoli cells is antigenically related to a protein associated with outer dense fibers of the sperm tail. therefore, we have explored the possibility that sertoli and spermatogenic cells express a similar gene encoding a homologous protein. a sertoli cell heterodimeric protein cdna probe recognizes specific mrna in pachytene and round spermatids fractionated by centrifugal elutriation; however, this specific mrna was less p ...	1992	1472368
doppler investigation of uteroplacental blood flow resistance in the second trimester: a screening study for pre-eclampsia and intrauterine growth retardation.		2006	1472202
clonal dental pulp cells (rdp4-1, rpc-c2a) synthesize and secrete osteopontin (spp1, 2ar).	dental pulp cells play an important role in maintaining dental mineralized tissue throughout life. supplementary mineralization such as reparative dentin and pulp stone frequently occurs after primary dentin formation. dental pulp cells are thought to be closely associated with such mineralization. we found that clonal rat dental pulp cells, rdp4-1 and rpc-c2a, produce and secrete osteopontin, but do not synthesize phosphophoryn which is a major noncollagenous protein found in dentin. the dental ...	1992	1472061
phenolic constituents in erythrina x bidwilli and their activity against oral microbial organisms.	five flavonoid compounds, including two new isoflavanones, were isolated from the root bark of erythrina x bidwilli. their structures were determined to be 2,10-di(gamma,gamma-dimethylallyl)-3,9-dihydroxypterocarpan (erythrabyssin ii), 6,8-di(gamma,gamma-dimethylallyl)-7,2',4'-trihydroxyisoflavanone (bidwillon a), 8-gamma,gamma-dimethylallyl-2',4'-dihydroxy-[6",6"-di-methylpyrano - (2",3":7,6)]isoflavanone (bidwillon b), 8-gamma,gamma-dimethylallyl-7,4'-dihydroxyisoflavone (8-gamma,gamma-dimethy ...	1992	1464104
inheritance of tomaculous neuropathy.		1997	1456749
cellular fatty acids in fusobacterium species as a tool for identification.	identification of fusobacteria from clinical specimens currently requires analysis of metabolic end products by gas-liquid chromatography in addition to certain biochemical and enzymatic tests because of the relative biochemical inactivity of these bacteria. even the finding of pointed, thin gram-negative cells on gram-stained slides can no longer be relied on for identification of fusobacterium nucleatum, since at least four other species of fusobacteria have been seen to exhibit similar morpho ...	1992	1452706
an unrecognized etiology for pyogenic hepatic abscesses in normal hosts: dental disease.	cryptogenic pyogenic hepatic abscesses are a diagnosis of exclusion. we have identified two patients with severe dental disease at the time of the diagnosis of their liver abscess. in both cases, oral flora was cultured from the abscess. unlike a previous report, both patients were immunocompetent. when compared with a group of patients with liver abscesses and diverticulitis, two differences were found. in contrast to the single abscesses seen in 10 of 10 patients with diverticulitis, the patie ...	1992	1449134
immunohistochemical localization of gangliosides in enu-induced rat glioma.	biochemical studies have indicated that the structurally simple gangliosides, including gd3 and gm3, are major glycolipid components of glioma tissues. in order to clarify the localization of the gangliosides in ethylnitrosourea-induced rat glioma, an immunohistochemical study was performed using antibodies against gm1, gm3, and gd3. the results obtained in normal fetus, newborn, and adult rat brain, and also in human glioma, were compared. in fetal and newborn rat brain, gd3 was present mainly ...	1992	1449052
[long-term follow-up after thyroidectomy: incidence of recurrent goiter and functional results].	we analyzed the postoperative longterm results after strumectomy for sporadic goiter in 26 patients. the follow-up time was 25.1 +/- 14.7 (7-58) years (x +/- sd, extremes). actual goiter recurrence without need for surgery was observed and sonographically confirmed in 3 patients, and 1 patient without actual recurrence had had a second strumectomy for goiter recurrence in the past. hence the overall frequency of goiter recurrence in this study is 15% (4/26 patients). the patients with a present ...	2006	1448680
[pathology of myxoid mitral valve degeneration: literature review and personal results].	mitral prolapse is a parachute-like protrusion of the value into the left atrium. almost always a myxoid degeneration of the valve is the base of such a prolapse. myxoid degeneration is understood as dissolution of the collagenous fibrous layer and its replacement by acid glucosaminoglycans. an alteration of collagen is suspected as primary defect in this sometimes also inherited disorder. the electron microscope reveals fragmentation of collagen fibrils and elastic fibers and, within the myxoid ...	2006	1448633
a comparative study of randomly amplified polymorphic dna analysis and conventional phage typing for epidemiological studies of listeria monocytogenes isolates.	the analysis of rapd profiles generated by pcr with a single 10-mer, hlwl74, was compared to bacteriophage susceptibility data for epidemiological typing of listeria monocytogenes strains. a total of 104 l. monocytogenes strains was screened, all from serogroup 1 or serotype 4b. of these, 53 had been isolated during 6 different listeriosis outbreaks. the remaining 51 strains were chosen randomly from our collection. a total of 38 rapd types were observed, although each epidemic group of strains ...	1992	1448626
"raynaud's disease" in migraineurs: one entity or two?	two cases are reported of patients who were diagnosed as having both migraine and raynaud's disease. because they were able to achieve effective control of both headaches and extremity temperature after undergoing a comprehensive approach--utilizing medication, biofeedback, and psychotherapy--it is suggested that both conditions are manifestations of the same disorder. it is recommended that a first step in approaching concurrent diagnoses of this type involve combined treatment as is often used ...	2006	1446993
comparison of the effects of galactose and glucose on the ph responses of human dental plaque, salivary sediment and pure cultures of oral bacteria.	comparisons made in dental plaque in vivo demonstrated that galactose produces a significantly smaller decrease in ph than does glucose. in vitro studies with plaque, salivary sediment and pure cultures of oral bacteria done in the absence of intraoral factors such as flowing saliva confirmed this lesser acidogenicity of galactose. pure culture showed that most of the bacteria tested produce a moderate to large decrease with glucose but only a few do so with galactose; most produced a moderate t ...	1992	1444892
complement activation by lipopolysaccharides purified from gram-negative bacteria isolated from infected root canals.	the purpose of the present study was to investigate the complement activation by lipopolysaccharides purified from porphyromonas (bacteroides) endodontalis, veillonella parvula, and fusobacterium nucleatum isolated from infected root canals. the rate of consumption of the c3t component of the complement increased remarkably when lipopolysaccharides of more than 10 micrograms were added.	1992	1437068
thrombocytopenia and the neglected megakaryocyte.		2006	1435936
pedigree analysis of children with phonology disorders.	this study examined 87 pedigrees of individuals with histories of preschool phonology disorders. results confirmed previous reports that speech and language disorders aggregate in families, with a higher incidence of males affected than females. significantly more family members with dyslexia and learning disabilities, but not stuttering or hearing impairment, were found in pedigrees of individuals with phonology disorders than in pedigrees of nondisabled individuals. probands with and without a ...	2006	1431544
mandatory testing?		2006	1426457
mannitol does not affect energy metabolism in forebrain ischemia.	mannitol has a beneficial effect on ischemic injury following a short-duration forebrain ischemic insult in rats. using the same animal model, we attempted to show that this effect of mannitol could be traced (via an improvement in cerebral blood flow) to a tempering of the collapse in the high-energy phosphates that occurs during the insult. a 10 min ischemic insult was induced by bilateral carotid artery occlusion followed by a reduction of the blood pressure to 50 mmhg through removal of bloo ...	1992	1421096
facial paralysis reconstruction with gore-tex soft-tissue patch.	no procedure perfectly restores a face paralyzed by surgical ablation of the facial nerve. although dynamic reconstructive procedures are preferred for treating patients with complete facial paralysis, various conditions contraindicate their use, making static suspension of the paralyzed face a reasonable surgical alternative. expanded polytef soft-tissue patch (polytetrafluoroethylene; gore-tex soft-tissue patch, gore-tex, w. l. gore & assoc inc., flagstaff, ariz) was used to help correct midfa ...	2006	1418899
2-hydroxyglutaryl-coa dehydratase from fusobacterium nucleatum (subsp. nucleatum): an iron-sulfur flavoprotein.	anaerobically prepared cell-free extracts from fusobacterium nucleatum contain 2-hydroxyglutaryl-coa dehydratase with a specific activity of 20 nkat mg-1. the enzyme was purified 24-fold to a specific activity of 480 nkat mg-1 by anion exchange chromatography, gel filtration and chromatography on blue-sepharose. the activity of the purified enzyme was strictly dependent on the reductant ti(iii)citrate and stimulated 25-fold by 0.15 mm atp and 5 mm mgcl2. atp is hydrolysed to adp during incubatio ...	1992	1417419
experimentally induced infection by oral anaerobic microorganisms in a mouse model.	a mouse model was developed to study the abscessogenic potential of pure and mixed cultures of oral anaerobes associated with infections of endodontic origin. maximum subcutaneous lesions were seen on their backs between 3 and 14 d after inoculation. strains of fusobacterium nucleatum, peptostreptococcus anaerobius, and veillonella parvula were pathogenic in pure culture. a mixed culture of f. nucleatum with either porphyromonas gingivalis or prevotella intermedia was significantly more pathogen ...	1992	1408362
study of acute intraoperative suprachoroidal hemorrhage.	acute intraoperative suprachoroidal hemorrhage or effusion (aish) was studied in a prospective manner over the past three years. in a general cataract surgery population of 2,523 patient eyes, 15 (0.6%) experienced an aish. results of a specific surgical management technique are presented. surgical control of the aish consisted of immediate closure of the incision and application of pressure directly to the eye. this tamponades the effusion or hemorrhage, which allows coagulation and completion ...	2006	1403754
longitudinal monitoring of humoral antibody in subjects with destructive periodontal diseases.	fifty-one subjects (16-61 years old) with evidence of prior destructive periodontal disease were monitored clinically and immunologically at bi-monthly intervals for up to 5 yr. periodontal disease activity, determined as new attachment loss, was detected in 33 of these subjects. only 4 of 51 subjects failed to show an elevated serum antibody level to any of the 18 subgingival species tested. the antibody level threshold established for periodontally healthy subjects was exceeded most often in d ...	1992	1403580
identification of proteases from periodontopathogenic bacteria as activators of latent human neutrophil and fibroblast-type interstitial collagenases.	activation of latent human fibroblast-type and neutrophil interstitial procollagenases as well as degradation of native type i collagen by supra- and subgingival dental plaque extracts, an 80-kda trypsinlike protease from porphyromas gingivalis (atcc 33277), a 95-kda chymotrypsinlike protease from treponema denticola (atcc 29522), and selected bacterial species commonly isolated in periodontitis was studied. the bacteria included were prevotella intermedia (atcc 25261), prevotella buccae (es 57) ...	1992	1398963
[lemierre's syndrome with splenic abscesses].	a week after onset of a pharyngo-tonsillitis a previously healthy 23-year-old man developed high fever (41.4 degrees c), leukocytosis (12,200/microliters) with marked shift to the left, thrombocytopenia (86,000/microliters) and increased transaminases (got 83 u/l, gpt 113 u/l). chest x-ray film suggested intrapulmonary abscesses with left-sided pleural effusion. the suspected diagnosis of "post-tonsillitis" septicaemia (lemierre's syndrome) was confirmed by demonstrating anaerobic, fusiform, gra ...	1992	1396137
the molecular genetics of schizophrenia.		2006	1393109
ec directives on medical devices.		2006	1392944
the establishment of human t cell lines reactive with specific periodontal bacteria.	human t cell lines (tcls) were obtained by stimulation of peripheral blood mononuclear cells (pbmcs) with the 2 periodontopathic bacteria, porphyromonas gingivalis fdc-381 and fusobacterium nucleatum fdc-263. after the first round of stimulation and rest, the cells responded specifically to the bacteria originally used to establish each line. throughout the culture period, the responsiveness of each of the tcls to their specific bacteria increased. phenotypic analysis of the tcls revealed hetero ...	1992	1383912
biochemical and functional characterization of the leucocyte tyrosine phosphatase cd45 (cd45ro, 180 kd) from human neutrophils. in vivo upregulation of cd45ro plasma membrane expression on patients undergoing haemodialysis.	the biochemical and functional characterization, and the regulation of plasma membrane expression of the leucocyte tyrosine phosphatase cd45, have been investigated in neutrophils from healthy donors and patients undergoing haemodialysis. cd45 proteins of 180 kd and 130-150 kd were precipitated from neutrophils from both healthy subjects and haemodialysed patients. prolonged storing, as well as trypsin treatment of samples containing the 180-kd cd45 protein, generated the 130-150-kd polypeptides ...	1992	1370931
cocaine/polydrug use in pregnancy: two-year follow-up.	the impact of cocaine on pregnancy and neonatal outcome has been well documented over the past few years, but little information regarding long-term outcome of the passively exposed infants has been available. in the present study, the 2-year growth and developmental outcome for three groups of infants is presented: group 1 infants exposed to cocaine and usually marijuana and/or alcohol (n = 106), group 2 infants exposed to marijuana and/or alcohol but no cocaine (n = 45), and group 3 infants ex ...	2005	1370867
dinucleotide (ca/gt) repeat polymorphism in intron 17b of the cystic fibrosis transmembrane conductance regulator (cftr) gene.	we describe a polymorphic microsatellite (ivs17bca) in intron 17b of the cystic fibrosis transmembrane conductance regulator (cftr) gene. it consists of an 11 to 20 ca/gt dinucleotide repeat, located 424 bp from exon 17b.	1992	1370810
regulation of annexin i in adipogenesis: camp-independent action of methylisobutylxanthine.	the differentiation of 3t3-l1 fibroblasts to adipocytes can be accelerated by the addition of 1-methyl-3-isobutylxanthine (mix), insulin, and dexamethasone to the culture medium. during differentiation, we have demonstrated that the level of both annexin i mrna and protein decreases. the half-times for this reduction were 2 h and 10 h for annexin i mrna and protein, respectively. of the added agents in the differentiation medium, only mix caused a decline in annexin i expression in 3t3-l1 fibrob ...	2005	1370745
expression of schwann cell and peripheral t-cell activation epitopes in hereditary motor and sensory neuropathy.	to evaluate possible immune-mediated mechanisms in hereditary motor and sensory neuropathy (hmsn-i, charcot-marie-tooth syndrome), we examined class ii major histocompatibility complex antigen expression (mhc-ii, hla-dr) in schwann cells and peripheral lymphocyte t-cell (ta1, cd26) activation in five unrelated adults with hmsn-i. evidence of increased activation expression was found in both compartments but the pattern did not suggest a general state of hyperimmunity or appear related to clinica ...	2004	1370667
myeloid and erythroid progenitor cells from normal bone marrow adhere to collagen type i.	one of the mechanisms by which normal hematopoietic progenitor cells remain localized within the bone marrow microenvironment is likely to involve adhesion of these cells to extracellular matrix (ecm) proteins. for example, there is evidence that uncommitted, hla-dr-negative progenitor cells and committed erythroid precursors (bfu-e) bind to fibronectin. however, fibronectin is not known to mediate binding of committed myeloid (granulocyte-macrophage) progenitors, raising the possibility that ot ...	2004	1370640
characterization of guanosine diphospho-d-mannose dehydrogenase from pseudomonas aeruginosa. structural analysis by limited proteolysis.	alginate is believed to be a major virulence factor in the pathogenicity of pseudomonas aeruginosa in the lungs of patients suffering from cystic fibrosis. guanosine diphospho-d-mannose dehydrogenase (gdpmannose dehydrogenase, ec 1.1.1.132) is a key enzyme in the alginate biosynthetic pathway which catalyzes the oxidation of guanosine diphospho-d-mannose (gdp-d-mannose) to gdp-d-mannuronic acid. in this paper, we report the structural analysis of gmd by limited proteolysis using three different ...	1992	1370473
sensitization of oral bacteria to killing by low-power laser radiation.	twenty-seven compounds were screened for their ability to sensitize streptococcus sanguis to killing by light from a 7.3-mw helium/neon (hene) laser. bacteria were mixed with various concentrations of the test compounds, spread over the surfaces of agar plates, and then exposed to light from the hene laser for various time periods. the plates were then incubated and examined for zones of inhibition. those compounds found to be effective photosensitizers were then tested against porphyromonas gin ...	1992	1369193
comparative studies on the mode of action of proctolin and phorbol-12,13-dibutyrate in their ability to contract the locust mandibular closer muscle.	the role of proctolin has been further investigated in the locust (locusta migratoria) mandibular closer muscles. radioactive calcium uptake measurements were made using protease-dissociated muscle cells. both the phorbol ester, phorbol-12,13-dibutyrate, and proctolin produce tonic contractions which are associated with the influx of extracellular calcium. the thresholds for proctolin and the phorbol ester to contract the muscle were 1-10 nm and 10-100nm, respectively, while their respective thr ...	2006	1360273
different responses in b cells induced by porphyromonas gingivalis and fusobacterium nucleatum.	a phenotypic study had shown that gingival b cells respond differently to two periodontopathic bacteria, porphyromonas gingivalis and fusobacterium nucleatum. further investigation now shows a reduction in the percentage of ki-67 + t cells in cultures of gingival and peripheral blood mononuclear cells stimulated with p. gingivalis for 3 and 6 days, respectively, but no suppression of ki-67 expression in b cells in response to either p. gingivalis or f. nucleatum. depletion studies of cultures of ...	1992	1359860
cd45ra and cd45ro positive cd4 cells in human peripheral blood and periodontal disease tissue before and after stimulation with periodontopathic bacteria.	flow cytometric analysis was used to examine naive and primed or memory cd4 cells extracted from periodontal lesions compared with cells from peripheral blood of healthy subjects before and after stimulation with the periodontopathic bacteria, porphyromonas gingivalis and fusobacterium nucleatum. in peripheral blood, approximately 60% and 40% of cd4 cells were cd45ro+ and cd45ra+ respectively at day 0. phytohaemagglutinin (pha) induced cd45ro expression on almost 100% of cd4 cells. however, p. g ...	1992	1356262
immunoglobulins in milk from cows immunized with oral strains of actinomyces, prevotella, porphyromonas, and fusobacterium.	immunization of pregnant cows with bacteria leads to the presence of high concentrations of specific antibodies in colostrum and milk. a total of 14 cows was immunized with single strains of heat-killed oral bacteria or pools of strains of actinomyces, porphyromonas, prevotella, and fusobacterium. two cows were treated with adjuvant alone. the mean percentages of igg1, igg2, igm, and iga in all of the milks were 83.8, 3.8, 9.3, and 3.1, respectively. elisa and whole cell agglutination assays dem ...	1992	1354674
tissue engineering. keystone symposia on molecular and cellular biology. april 3-10, 1992. abstracts.		2006	1351964
detubularization-induced contractile response change of the ileum following ileocystoplasty.	we reported previously that following ileocystoplasty the structure and pharmacologic response of the implanted ileum changes towards that of the bladder. specifically, the relaxation response to alpha adrenergic (methoxamine) and purinergic (atp) stimulation reverses to a contractile response one month after the ileal segment is surgically made part of the urinary bladder. the present study was designed to investigate possible signals for this change and also to determine whether bladder respon ...	1992	1351953
recommendations on the use of ultrasound and doppler technology in clinical obstetrics and gynecology. figo study group on the assessment of new technology.		2005	1351013
structure of holo-chaperonin studied with electron microscopy. oligomeric cpn10 on top of two layers of cpn60 rings with two stripes each.	a structural model of holo-chaperonin, known as a protein-folding control protein comprising 60 kda (cpn60) and 10 kda polypeptides (cpn10), is proposed based on the electron microscopic images of holo-chaperonin from thermus thermophilus and cpn60 from paracoccus denitrificans. isolated paracoccus cpn60 shows very similar images to those of escherichia coli tetradecameric cpn60, a seven-membered ring in the top view and a rectangular shape with four stripes in the side view. however, a small nu ...	1992	1347504
endotoxin antibody for sepsis in infants.		2006	1347362
rediscovering wormwood: qinghaosu for malaria.		2006	1347342
thymocytopoiesis is maintained by blood-borne precursors throughout postnatal life. a study in parabiotic mice.	this study was designed to resolve the long standing controversy as to whether hematogenous precursors or resident intrathymic precursors maintain thymocytopoiesis in postnatal life. the kinetics of thymic chimerism was examined over a 21-wk period in 105 pairs of nonirradiated, thy-1-alloantigen-disparate, parabiotic b10.s mice. thymic chimerism reached reached maximum levels of 25% in the thy-1b and 16% in the thy-1a partners (mean 20.5% and 9.8%, respectively) 6 to 7 wk after parabiotic union ...	2006	1347301
antigen-receptor complex stimulation triggers protein kinase c-dependent cd11a/cd18-cytoskeleton association in t lymphocytes.	although it is well accepted that intercellular adhesion involving the cd11a/cd18 (lfa-1) complex is critical in a wide array of t cell-dependent processes, recent demonstrations of an lfa-1 high avidity state, induced by triggering the t cell receptor (tcr) complex, has raised questions about the intracellular signals generated and molecular events leading to effective cell coupling, as well as their orderly sequence. in this study, we assessed the effects of t cell activation on the actin-base ...	2006	1346786
release of endogenous noradrenaline from the vascularly perfused rat stomach in vitro: modulation by pre- and postsynaptic adrenoceptors.	we developed an experimental in vitro model to detect a very small amount of endogenous noradrenaline (na) released from the rat gastric sympathetic nerve terminals. the stomach was perfused via celiac artery with modified krebs-ringer solution containing 10 mm pargyline and 0.1% bovine serum albumin at a constant flow of 4 ml/min. the right greater splanchnic (spl) nerve (preganglionic nerve of the gastric sympathetic nerve) was stimulated electrically with square-wave pulses of 2 msec duration ...	1992	1346643
effect of the vibratory acoustic stimulation on fetal heart rate patterns of premature fetuses.	the purpose of this study was to examine the heart rate patterns before and after a standardized external vibratory acoustic stimulation in a group of 24 healthy premature fetuses at 32-35 weeks gestational age. fhr was analysed on line by sonicaid computer system 8000. a significant increase in the number of accelerations and an increase of variation after stimulus were observed. all other fhr patterns such as baseline, high and low episodes did not change significantly.	2006	1346598
effect of beta-lactamase inhibitors on beta-lactamases from anaerobic bacteria.	three beta-lactamase inhibitors in clinical use--clavulanic acid, sulbactam and tazobactam--were investigated for their activity on beta-lactamases from bacteroides uniformis, clostridium butyricum and fusobacterium nucleatum. purification of the beta-lactamases was carried out by anion-exchange chromatography, gel filtration and fplc. the inactivation of beta-lactamase activity was determined spectrophotometrically with nitrocefin as substrate. various concentrations of the inhibitors were prei ...	1992	1338315
antibacterial efficacy of root canal medicaments.	the antibacterial efficacy of four endodontic medicaments was studied in vitro. calcium hydroxide (calacept), camphorated parachlorophenol (cpcp), cresophene, and 2% iodine-potassium iodide (iki) were tested against four anaerobic microorganisms, streptococcus mutans, peptostreptococcus anaerobius, porphyromonus gingivalis and fusobacterium nucleatum, for 10 or 15 min. iki was effective only against f. nucleatum and p. gingivalis, and the others were effective against all four microorganisms.	1992	1337555
dna probe and enzyme analysis in periodontal diagnostics.	recent research in periodontology has indicated that a finite number of bacterial species are associated with periodontal disease. this has generated the hypothesis that periodontal disease is essentially an infection due to one or more of the putative periodontopathogens; i.e., the specific plaque hypothesis (sph). this microbial specificity paradigm has already changed the way researchers and some clinicians view periodontal disease. the clinician must heed several cautions signs, however, if ...	1992	1336048
bacterial concentration fluorescence immunoassay (bcfia) for the detection of periodontopathogens in plaque.	a bacterial concentration fluorescence immunoassay (bcfia) was developed to rapidly detect periodontopathic bacteria in human plaque samples. the bcfia utilized fluorescent-tagged monoclonal antibodies (mabs) directed against the lipopolysaccharide of selected gram-negative bacteria. microorganisms identified in plaque using the bcfia included actinobacillus actinomycetemcomitans, porphyromonas gingivalis, prevotella intermedia, and fusobacterium nucleatum. the immunoassay procedure involved com ...	1992	1336047
sensitization of oral bacteria in biofilms to killing by light from a low-power laser.	biofilms of streptococcus sanguis, porphyromonas gingivalis, fusobacterium nucleatum and actinobacillus actinomycetemcomitans were prepared on the surfaces of agar plates and a number of compounds were screened for their ability to sensitize bacteria in these biofilms to killing by light from a 7.3 mw helium/neon (he/ne) laser. toluidine blue o and methylene blue enabled detectable killing of all four target organisms after exposure to he/ne light for 30 s. aluminium disulphonated phthalocyanine ...	1992	1334649
correlation of haemagglutination activity with trypsin-like protease activity of porphyromonas gingivalis.	porphyromonas gingivalis is a gram-negative anaerobic bacterium associated with various forms of periodontal disease. several characteristics of p. gingivalis are thought to contribute to its pathogenicity; these include haemagglutination and trypsin-like protease activity. previous studies suggest an association between haemagglutination and trypsin-like protease activity of p. gingivalis. to investigate this, two complementary quantitative experimental approaches were taken. five independent m ...	1992	1332663
effect of clavulanic acid, sulbactam and tazobactam on three different beta-lactamases from bacteroides uniformis, clostridium butyricum and fusobacterium nucleatum.	the effect of three beta-lactamase inhibitors, clavulanic acid, sulbactam and tazobactam used in clinical practice were compared for their activity against purified beta-lactamases from bacteroides uniformis, clostridium butyricum and fusobacterium nucleatum. the enzymes from b. uniformis and c. butyricum were produced in fermenters under controlled growth conditions and the enzyme from f. nucleatum was produced in batch cultures. purification of the beta-lactamases was achieved by anion-exchang ...	1992	1331018
role of porphyromonas gingivalis 40-kda outer membrane protein in the aggregation of p. gingivalis vesicles and actinomyces viscosus.	porphyromonas gingivalis, an important pathogen in periodontitis, produces extracellular vesicles that aggregate with actinomyces viscosus cells. a 40-kda outer membrane protein (omp)-coding gene from p. gingivalis was cloned and the protein was found to be localized in these vesicles. the recombinant 40-kda omp did not show aggregation activity. however, affinity-purified antibody against the recombinant protein significantly inhibited aggregation of p. gingivalis vesicles with a. viscosus cell ...	1992	1329700
femtosecond biology.		2003	1326353
synergistic effect of pyrophosphate and sodium dodecyl sulfate on periodontal pathogens.	our previous studies have shown that pyrophosphate (ppi), the anticalculus component of tartar-control dentifrices, inhibits the growth of organisms associated with coronal and root surface caries. the purposes of this investigation were to: 1) determine if periodontal pathogens are similarly susceptible to the growth-inhibitory properties of ppi; and 2) determine if combinations of pyrophosphate-sodium dodecyl sulfate (ppi-sds) inhibit growth synergistically. porphyromonas gingivalis, actinobac ...	1992	1324304
subgingival temperature (iii). relation to microbial counts.	the present investigation examined the relationship of selected bacterial species and subgingival temperature. 35 subjects were measured at 6 sites per tooth for clinical parameters and subgingival temperature. measurements were repeated for 21 subjects at 2 month intervals providing a total of 66 subjects visits. at each visit, subgingival plaque samples were taken from the mesial aspect of each tooth and anaerobically dispersed, diluted and plated on non-selective media. after anaerobic incuba ...	1992	1321846
new monoclonal antibodies for the detection of immediate early antigens of cytomegalovirus.	two new monoclonal antibodies, cie-1 and cie-2, were developed for the rapid detection of human cytomegalovirus (hcmv) infection. they were found to be reactive with immediate early protein of hcmv in the nuclei of infected fibroblasts, as early as 3 hours post-infection. by radioimmunoprecipitation, cie-1 was found to react with a protein with an apparent molecular weight of 70,000, whereas cie-2 precipitated 2 proteins of 70,000 and 72,000 daltons, respectively. both monoclonal antibodies reco ...	1992	1319172
the use of dna probes to examine the distribution of subgingival species in subjects with different levels of periodontal destruction.	the present investigation examined the distribution of 14 subgingival species at a total of 2299 sites in 90 subjects with different levels of periodontal destruction. subgingival plaque samples taken from the mesial aspect of each tooth were anaerobically dispersed, diluted and plated on non selective media. after anaerobic incubation, colonies were lifted to nylon filters and specific species detected using digoxygenin-labeled whole chromosomal dna probes. the mean total viable count for all s ...	1992	1318331
[molecular bases of chronic granulomatous disease--analysis of the involvement of cytosol factors for nadph oxidase].	during the past 5 years, the discovery of cell-free superoxide generation system (bromberg y, pick e: cell immunol 88:213-221, 1984) has been revolutionized our understanding of phagocyte superoxide generation. using cell-free system, it was clarified that nadph oxidase for superoxide generation was comprised of components present in both the plasma membrane as well as in the cytosol. this oxidase could be kept inactive by keeping its components separated from each other within the cell and then ...	2005	1317471
gabaa receptors control the excitability of neuronal populations.		2005	1317365
interactions of praseodymium and neodymium with nucleosides and nucleotides: absorption difference and comparative absorption spectral study.	the interactions of praseodymium(iii) and neodymium(iii) with nucleosides and nucleotides have been studied in different stoichiometry in water and water-dmf mixtures by employing absorption difference and comparative absorption spectrophotometry. the 4f-4f bands were analysed by linear curve analysis followed by gaussian curve analysis, and various spectral parameters were computed, using partial and multiple regression method. the magnitude of changes in both energy interaction and intensity w ...	2005	1317348
analyzing phenotypic correlations in studies with selected lines.		1992	1317160
use of adeno-associated virus as a general transduction vector for mammalian cells.		1992	1316261
microbiology of healthy and diseased periodontal sites in poorly controlled insulin dependent diabetics.	a group of poorly-controlled insulin dependent diabetes mellitus (iddm) patients were examined in a cross-sectional design for total microbial levels, microbial incidence, and the percent levels of selected periodontal microorganisms. these organisms were selected on the basis of prior reports that associated them with either periodontal disease or health. one periodontally-healthy and one periodontally-diseased site were examined in each iddm patient. increased levels of the periodontal pathoge ...	1992	1315389
the effect of 3 mouthrinses on plaque and gingivitis development.	the aim of this study was to evaluate the effect of 3 mouthrinses, listerine antiseptic (thymol), peridex (chlorhexidine), perimed (povidone iodine and hydrogen peroxide), and a placebo (water) on the development of dental plaque and gingivitis, when used as the only oral hygiene procedure for 14 days. 71 subjects were entered into a randomized, double-blind study. at the baseline examination, papillary bleeding score (pbs), and plaque index (pi) were registered, after which subjects received su ...	1992	1310096
hypoxic-ischemic damage in the neonatal brain: excitatory amino acids.	perinatal brain damage is a major clinical problem. recent studies suggest that excitatory amino acids (eaas) may be important for the development of hypoxic-ischemic brain injury in the newborn. experimental work demonstrates that the immature brain is hypersensitive to the toxic effects eaa ('excitotoxicity'), hypoxic-ischemia is accompanied by an extracellular overflow of eaas and hypoxic-ischemic brain damage is reduced by eaa receptor antagonists. clinical investigations demonstrate the pre ...	1992	1306803
expression and release of neuroregulators during development: monoamines and neuropeptides.	the turnover of catecholamines (ca) was determined in the adrenal medulla and brain of rat fetuses and pups. in general we found a considerable increase soon after birth. the expression of mrna for ca-synthesizing enzymes was also considerably enhanced in the adrenals shortly after birth. furthermore, we demonstrated increased expression of neuropeptides after birth, increased synthesis of mrna encoding for neuropeptide y in the adrenals 24 h after birth; and considerable activation of the subst ...	1992	1306802
soft-tissue management through effective patient subgingival bacterial control.		1992	1291435
myocardial protection by retrograde cardioplegic perfusion in the presence of acute coronary artery obstruction. an experimental study.	to investigate retrograde delivery of cardioplegic solutions as a means of enhancing myocardial protection in the presence of coronary artery occlusion, a two-part experimental model was devised. in part 1 (in vitro) the possibility of retroperfusing the entire myocardium during acute occlusion of the left anterior descending artery (lad) was assessed. in part 2 (in vivo) acute lad occlusion was performed in dogs, and during 2 hours of aortic cross-clamping crystalline cardioplegic solution was ...	1992	1287835
prevalence studies of problematic behaviors in four-year-olds.	prevalence rates for specific behaviors in the problem behavior questionnaire (pbq; behar & stringfield, 1974) and for four psychosomatically related behaviors (soiling, day and night wetting, and complaints about bodily aches) were estimated in a sample of 377 swedish 4-year-olds described by their parents (mainly mothers). the results showed that several of the behaviors classified as outgoing conduct problems were common in this age group; boys showed more problematic behaviors than girls, as ...	2005	1287827
[treatment and monitoring of primary hypothyroidism].	treatment of primary hypothyroidism requires a long-term hormonal therapy with levothyroxine which restores a normal tsh value. in a series of 192 patients followed up for at least 3 years we tried to evaluate the variability of maintenance dosage and to analyse the factors predictive of replacement dosage. the l-t4 dosage varied from one individual to the other, from 0.6 to 3.2 micrograms/kg. the mean maintenance dosage (118 +/- 38 micrograms/day) was similar in men and women weight for weight, ...	1992	1287777
regeneration of an adult peripheral nerve preparation in culture.	the methods used to maintain the vagus nerve from the adult rat in culture and how regeneration is studied in this preparation are described. a hypothesis is presented on the triggering of the cell body reaction. it is suggested that this reaction is initiated by proteins synthesized in nonneuronal cells at the site of a nerve lesion. these proteins, referred to as regenerins, reach the nerve cell body by retrograde axonal transport, where they initiate the regeneration process.	1992	1282333
development and characterization of porphyromonas gingivalis-specific rat t-cell clones.	porphyromonas gingivalis has been implicated as a major pathogen in periodontitis. to determine the role of t cells in the regulation of this disease, a method was developed for the generation and characterization of rat t-cell clones with antigen specificity to p. gingivalis whole cells. the clones studied so far demonstrated a t-helper (th) phenotype w3/13+, w3/25+, ox8- and ox22-. these t-cell clones proliferated in vitro in response to p. gingivalis, but not to other bacteria (prevotella int ...	1992	1281976
dofetilide, a novel class iii antiarrhythmic agent.	dofetilide is a potent and selective class iii antiarrhythmic agent that is under development for the treatment of re-entrant tachyarrhythmias (ventricular tachycardia/ventricular fibrillation, atrial fibrillation/atrial flutter, and paraoxysmal supraventricular tachycardia). in animal studies, dofetilide selectively inhibits the rapid component of the time-dependent outward potassium current (ikr) and therefore increases the effective refractory period and action potential duration without affe ...	1992	1279316
absolute configuration of 3-hydroxy fatty acids present in lipopolysaccharides from various bacterial groups.	the absolute configuration of 3-hydroxy fatty acids has been studied, which are present in the lipopolysaccharides of the following bacteria: phodopseudomonas gelatinosa, rh. viridis, rhodospirillum tenue, chromobacterium violaceum, pseudomonas aeruginosa, bordetella pertussis, vibrio metchnikovii, vibrio cholerae, salmonella spp., escherichia coli, shigella flexneri, proteus mirabilis, yersinia enterocolitica and fusobacterium nucleatum. the 3-hydroxy acids were liberated by strong alkaline hyd ...	1976	1278168
[test of degranulation of basophils and mast cells for detection of allergic diseases (literature survey)].		1976	1274295
acute toxicity of mevinphos to gerbils.		2005	1273839
rosamicin: in vitro activity against anaerobes and comparison with erythromycin.	the in vitro activity of rosamicin was determined against 231 strains of anaerobic bacteria and compared with the activity of erythromycin against the same strains. rosamicin and erythromycin had similar activity against strains of peptostreptococcus and gram-positive nonsporeforming bacilli. rosamicin was somewhat more active against strains of peptococcus, clostridium, and gram-negative anaerobes. all strains of bacteroides fragilis tested were inhibited by 4 mug of rosamicin or less per ml, w ...	1976	1267432
hyperbaric oxygen exposures for intrahepatic abscesses produced in mice by nonsporeforming anaerobic bacteria.	hyperbaric oxygen exposures were evaluated for treatment of progressive liver abscesses produced by intraperitoneal injection of combined cultures of fusobacterium necrophorum plus either bacteroides fragilis subsp. fragilis or fusobacterium nucleatum in a mouse model. infected control and hyperbaric oxygen-exposed mice were autopsied 5 or 6 weeks after inoculation of bacteria and were assigned numerical pathology scores according to the number and size of abscesses present. seventeen daily 3-h ...	1976	1267430
attenuated, streptomycin-dependent salmonella typhi oral vaccine: potential deleterious effects of lyophilization.	four studies were done with streptomycin-dependent salmonella typhi as an oral, attenuated vaccine. studies 1 and 3 employed freshly harvested vaccine, whereas studies 2 and 4 involved lyophilized vaccine. five to eight doses (3 x 10(10)-10(11) organisms/dose) were given; oral streptomycin (1.0 g) was administered concomitantly in studies 2 and 3, with only two of the doses of vaccine in study 1, and was not given in study 4. no adverse reactions were encountered in 179 vaccinated men, and 94% o ...	1976	1262709
the detection of antibodies in human and animal filariases by counterimmunoelectrophoresis with dirofilaria immitis antigens.	counterimmunoelectrophoresis revealed the presence of precipitin antibody in all of 6 dogs and the 1 cat infected with dirofilaria immitis and in the serum of 17 of 24 individuals living in a setting of hyperendemic subperiodic bancroftian filariasis. antigens used in the test were prepared from microfilariae and adult male d. immitis. some humans and animals had antibodies to both antigens while others had antibodies against microfilariae or adult worms only. the presence of soluble circulating ...	1976	1262695
editorial: misleading statistics.		2005	1247832
the efficiency of aquocobalamine as an antidote in cyanide poisoning when given alone or combined with sodium thiosulfate.	the antidotal activities of aquocobalamineacetates and sodium thiosulfate were tested in guinea pigs and cats. the animals were attached to artificial respirators throughout the experiment and were poisoned with a continuous infusion of sodium cyanide solution (4.1 mumol/kg.min nacn). the rate of action of each antidote was determined from the time taken for the hcn exhalation to drop below the level of 100 nmol/kg.min in quinea pigs, and to values below 25 nmol/kg.min in cats; the detoxifying c ...	1975	1242295
[current etiopathogenic view of idiopathic hypertrophic subaortic stenosis. study of 3 brothers with this disease].		2005	1237159
[case of d/e translocation 45, xx, 13--, 18--, t(18q+, 13--)].		1975	1234109
[studies on the protein and amino acid metabolism of laying hens using 15n labeled casein. 15n concentration in the intestinal content and intestinal tissue in relation to the time of the last 15n administration].	four laying hens with anus praeternaturalis were fed 15n casein for a period of 6 experimental days. each experimental bird thus received a 15n excess (15n') of 154.44 mg. 11.54 mg of 15n' were found in lysine 3.99 mg in histidine and 9.58 mg in arginine. 2 hens were slaughtered 48 hours after the last 15n dose; another 2 were sacrificed after 144 hrs. in this investigation the n content of the intestinal contents and in the proteins of the small and large intestine were determined. the average ...	1975	1233975
[studies on the use of wheat rich in crude proteins in the feeding of broilers. 2. carcass yields and carcass composition].	studies were made to investigate whether the the substitution of maize for high-protein wheat fed in combination with different protein in fattening rations to broilers would influence the carcass yields and chemical carcass composition of broilers. the described dietary regime was not found to have a significant influence on the different criteria of carcass composition (roaster carcass, flesh, abdominal fat, total proportion of utilizable parts) with the exception of the relative proportion of ...	1975	1233971
[effect of x-rays on human adult skin explants].		1975	1233920
effects of helicopter noise on pilots' hearing.		2005	1231074