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selected dietary (poly)phenols inhibit periodontal pathogen growth and biofilm formation.periodontitis (pd) is a chronic infectious disease mediated by bacteria in the oral cavity. (poly)phenols (pps), ubiquitous in plant foods, possess antimicrobial activities and may be useful in the prevention and management of periodontitis. the objective of this study was to test the antibacterial effects of selected pps on periodontal pathogens, on both planktonic and biofilm modes of growth. selected pps (n = 48) were screened against streptococcus mitis (s. mitis), aggregatibacter actinomyce ...201525585200
microbial leakage at the implant-abutment connection due to implant insertion maneuvers: cross-sectional study 5 years postloading in healthy patients.the aim of this study was to test if stress on the prosthetic connection during insertion maneuvers can induce micro-warping at the implant connection. from september 2011 to july 2013, patients with implants loaded for at least 5 years that were placed with 2 different insertion implant mounters-mp (conventional) and me (mountless)-were selected from all of those who had received dental implant therapy in the past and were attending routine check-up or spontaneous visits during the study period ...201525536224
distribution of 8 periodontal microorganisms in family members of chinese patients with aggressive periodontitis.to date, no information on the distribution of periodontal microorganisms among family members of chinese patients with aggressive peridontitis (agp) is available. the aim of the present study was to investigate the probability of transmission of eight periodontal microorganisms between patients with aggressive periodontitis and their family members.201525526624
regulation of adrenomedullin and nitric oxide production by periodontal bacteria.in periodontitis the host response to bacterial challenge includes activity of the multifunctional molecules adrenomedullin (am) and nitric oxide (no). the aim of this study was to investigate the role of periodontal bacteria in regulating the production of these molecules from cultured cells.201525440112
relationship between expression of human gingival beta-defensins and levels of periodontopathogens in subgingival plaque.human beta-defensins (hbds) are a group of antimicrobial peptides important in epithelial innate immunity, and their differential expression is associated with periodontal diseases. the aim of this study was to explore relationships among hbds, total subgingival bacteria and periodontopathogens in healthy subjects and in patients with chronic periodontitis.201524814979
the interaction of implant luting cements and oral bacteria linked to peri-implant disease: an in vitro analysis of planktonic and biofilm growth--a preliminary study.there is little consensus on the most appropriate cement to use when restoring a cement-retained, implant-supported restoration. one consideration should be the interaction of pathogenic oral bacteria with restorative cements.201524909337
internal bacterial colonization of implants: association with peri-implant bone loss.the aim of the present longitudinal study was to investigate bacterial colonization of the internal implant cavity and to evaluate a possible association with peri-implant bone loss.201524861845
microbiological assessment of the implant-abutment interface in different connections: cross-sectional study after 5 years of functional loading.to evaluate the bacterial microflora present inside the implant connection and in the peri-implant sulcus fluid of healthy implants, and to analyze the relationships between these harboring sites for four different implant systems after at least 5 years of functional loading.201524665919
the in vitro antimicrobial efficacy of pdt against periodontopathogenic bacteria.periodontitis, an inflammatory disease, is caused by biofilms with a mixed microbial etiology and involves the progressive destruction of the tooth-supporting tissues. a rising number of studies investigate the clinical potential of photodynamic therapy (pdt) as an adjunct during active therapy. the aim of the present review was to evaluate the available literature for the in vitro antimicrobial efficacy of photodynamic therapy focusing on the periodontopathogenic bacteria aggregatibacter actino ...201526580607
scaling and root planning, and locally delivered minocycline reduces the load of prevotella intermedia in an interdependent pattern, correlating with symptomatic improvements of chronic periodontitis: a short-term randomized clinical trial.to evaluate the respective or combinatory efficacy of locally delivered 2% minocycline (mo), and scaling and root planning (srp) by assessing both clinical parameters and the loads of four main periodontal pathogens in treating chronic periodontitis (cp).201526676022
evaluation of the antibacterial effect of silver nanoparticles on guided tissue regeneration membrane colonization--an in vitro study.the aim of this in vitro study was to investigate the colonization and penetration of specific bacteria on nanosilver-impregnated gtr (guided tissue regeneration) membranes.201526373223
coinfection with fusobacterium nucleatum can enhance the attachment and invasion of porphyromonas gingivalis or aggregatibacter actinomycetemcomitans to human gingival epithelial cells.this study was conducted to investigate effects of coinfection of porphyromonas gingivalis (p. gingivalis) or aggregatibacter actinomycetemcomitans (a. actinomycetemcomitans) with fusobacterium nucleatum (f. nucleatum) on their adhering and invasive capacity to human gingival epithelial cells as well as the expression of interleukin-8 (il-8) and human beta-defensin-2 (hbd-2) in human gingival epithelial cells.201526143497
total antioxidant capacity and total oxidant status in saliva of periodontitis patients in relation to bacterial load.the detection of salivary biomarkers has a potential application in early diagnosis and monitoring of periodontal inflammation. however, searching sensitive salivary biomarkers for periodontitis is still ongoing. oxidative stress is supposed to play an important role in periodontitis progression and tissue destruction. in this cross-sectional study, we investigated total antioxidant capacity (tac) and total oxidant status (tos) in saliva of periodontitis patients compared to healthy controls and ...201526779448
polymicrobial oral infection with four periodontal bacteria orchestrates a distinct inflammatory response and atherosclerosis in apoe null mice.periodontal disease (pd) develops from a synergy of complex subgingival oral microbiome, and is linked to systemic inflammatory atherosclerotic vascular disease (asvd). to investigate how a polybacterial microbiome infection influences atherosclerotic plaque progression, we infected the oral cavity of apoe null mice with a polybacterial consortium of 4 well-characterized periodontal pathogens, porphyromonas gingivalis, treponema denticola, tannerealla forsythia and fusobacterium nucleatum, that ...201526619277
proteomic profiling of host-biofilm interactions in an oral infection model resembling the periodontal pocket.periodontal infections cause inflammatory destruction of the tooth supporting tissues. we recently developed a dynamic, in vitro periodontal organotypic tissue model in a perfusion bioreactor system, in co-culture with an 11-species subgingival biofilm, which may recapitulate early events during the establishment of periodontal infections. this study aimed to characterize the global proteome regulations in this host-biofilm interaction model. semi-quantitative shotgun proteomics were applied for ...201526525412
humoral immune responses to periodontal pathogens in the elderly.elderly people are thought to be more susceptible to periodontal disease due to reduced immune function associated with aging. however, little information is available on the nature of immune responses against putative periodontal pathogens in geriatric patients. the purpose of this study was to evaluate the serum igg antibody responses to six periodontal pathogens in geriatric subjects.201526550526
the effect of bamboo leaf extract solution and sodium copper chlorophyllin solution on growth and volatile sulfur compounds production of oral malodor associated some anaerobic periodontal bacteria.bamboo leaf extract solution (bles) and sodium copper chlorophyllin solution (sccs) are known for their anti-oxidant activities. oral malodor is often related with periodontal pathogens. the present study was undertaken to investigate the anti-bacterial effect of both bles and sccs on anaerobic periodontal bacteria producing oral malodorous volatile sulfur compounds (vsc).201526538799
incorporation of staphylococci into titanium-grown biofilms: an in vitro "submucosal" biofilm model for peri-implantitis.staphylococcus spp. are postulated to play a role in peri-implantitis. this study aimed to develop a "submucosal" in vitro biofilm model, by integrating two staphylococci into its composition.201526461083
periodontal pathogens invade gingiva and aortic adventitia and elicit inflammasome activation in αvβ6 integrin-deficient mice.the american heart association supports an association between periodontal diseases and atherosclerosis but not a causal association. this study explores the use of the integrin β6(-/-) mouse model to study the causality. we investigated the ability of a polymicrobial consortium of porphyromonas gingivalis, treponema denticola, tannerella forsythia, and fusobacterium nucleatum to colonize the periodontium and induce local and systemic inflammatory responses. polymicrobially infected itgβ6(-/-) m ...201526371120
periodontal pathogens and tetracycline resistance genes in subgingival biofilm of periodontally healthy and diseased dominican adults.the objective of this study was to compare the periodontopathogen prevalence and tetracycline resistance genes in dominican patients with different periodontal conditions.201526121972
fusobacterium nucleatum alters atherosclerosis risk factors and enhances inflammatory markers with an atheroprotective immune response in apoe(null) mice.the american heart association supports an association between periodontal disease (pd) and atherosclerotic vascular disease (asvd) but does not as of yet support a causal relationship. recently, we have shown that major periodontal pathogens porphyromonas gingivalis and treponema denticola are causally associated with acceleration of aortic atherosclerosis in apoenull hyperlipidemic mice. the aim of this study was to determine if oral infection with another significant periodontal pathogen fuso ...201526079509
effects of hangeshashinto on growth of oral microorganisms.oral mucositis (om) in cancer patients induced by chemotherapy or radiotherapy has a significant impact on quality of life, and causes considerable morbidity. oral microorganisms are likely to intensify the inflammatory process and aggravate the formation of ulcers. hangeshashinto (hst), a japanese kampo medicine, has been reported to be effective when used as a gargle for the treatment of om. to clarify the effects of hst on oral microorganisms, we assessed its antimicrobial activity against 27 ...201526170876
coaggregation and biofilm growth of granulicatella spp. with fusobacterium nucleatum and aggregatibacter actinomycetemcomitans.members of fastidious granulicatella and aggregatibacter genera belong to normal oral flora bacteria that can cause serious infections, such as infective endocarditis. aggregatibacter actinomycetemcomitans has long been implicated in aggressive periodontitis, whereas dna-based methods only recently showed an association between granulicatella spp. and dental diseases. as bacterial coaggregation is a key phenomenon in the development of oral and nonoral multispecies bacterial communities it would ...201526025449
development of in vitro denture biofilm models for halitosis related bacteria and their application in testing the efficacy of antimicrobial agents.since dentures can serve as a reservoir for halitosis-causing oral bacteria, halitosis development is a concern for denture wearers. in this study, we surveyed the prevalence of four selected halitosis-related species (fusobacterium nucleatum, tannerella forsythia, veillonella atypica and klebsiella pneumoniae) in clinical denture plaque samples, and developed denture biofilm models for these species in vitro to facilitate assessment of antimicrobial treatment efficacy. design : denture plaque f ...201525926895
prelude to oral microbes and chronic diseases: past, present and future.associations between oral and systemic health are ancient. oral opportunistic bacteria, particularly, porphyromonas gingivalis and fusobacterium nucleatum, have recently been deviated from their traditional roles as periodontal pathogens and arguably ascended to central players based on their participations in complex co-dependent mechanisms of diverse systemic chronic diseases risk and pathogenesis, including cancers, rheumatoid-arthritis, and diabetes.201525813714
laser supported reduction of specific microorganisms in the periodontal pocket with the aid of an er,cr:ysgg laser: a pilot study.the aim of this study was to evaluate the effectiveness of a radial firing tip of an er,cr:ysgg laser as an adjunct to a nonsurgical periodontal treatment.201525879057
bacterial profile of aggressive periodontitis in morocco: a cross-sectional study.aggressive periodontitis (agp) is one of the most severe forms of periodontal diseases. in morocco, aggregatibacter actinomycetemcomitans has been strongly associated with agp, however limited knowledge is available about the implication of other periodontal pathogens in this entity. therefore, the main aim of this study was to evaluate the composition of the subgingival microbiota in moroccan patients with agp.201525888404
the biofilm community-rebels with a cause.oral biofilms are one of the most complex and diverse ecosystem developed by successive colonization of more than 600 bacterial taxa. development starts with the attachment of early colonizers such as actinomyces species and oral streptococci on the acquired pellicle and tooth enamel. these bacteria not only adhere to tooth surface but also interact with each other and lay foundation for attachment of bridging colonizer such as fusobacterium nucleatum followed by late colonizers including the re ...201526120510
synergic phototoxic effect of visible light or gallium-arsenide laser in the presence of different photo-sensitizers on porphyromonas gingivalis and fusobacterium nucleatum.according to the development of resistant strains of pathogenic bacteria following treatment with antimicrobial chemotherapeutic agents, alternative approaches such as lethal photosensitization are being used. the aim of this study was to evaluate the effect of visible light and laser beam radiation in conjugation with three different photosensitizers on the survival of two main periodontopathogenic bacteria including porphyromonas gingivalis and fusobacterium nucleatum in different exposure per ...201526288621
abnormal pregnancy outcomes in mice using an induced periodontitis model and the haematogenous migration of fusobacterium nucleatum sub-species to the murine placenta.to investigate if there is subspecies specific migration to the placenta by fusobacterium nucleatum (fn) and to determine whether experimentally induced periodontitis results in adverse pregnancy outcomes (apo) in mice.201525806806
plasma digoxin concentrations in patients on admission to hospital. 20154415091
isph-rps1 and isph-ubia: "rosetta stone" proteins.the protein isph, (e)-1-hydroxy-2-methyl-but-2-enyl 4-diphosphate (hmppp) reductase, is an essential 4fe-4s cluster-containing protein in the methylerythritol phosphate pathway for isoprenoid biosynthesis. using a sequence similarity network we found that there are >400 isph proteins that are about twice as large as most of the isphs studied to date since their isph domains are fused to either the ribosomal protein s1 (rps1), or to a ubia (4-hydroxybenzoate octaprenyltransferase)-like protein. m ...201526865948
[early radiographic manifestations of left ventricular circulatory failure in acute myocardial infarct. radiographic-clinical correlations]. 20154660874
[radiosterilization of medical products. iv. effects of gamma-radiation on physical and chemical properties of disposable infusion assemblies]. 20154677261
robust species taxonomy assignment algorithm for 16s rrna ngs reads: application to oral carcinoma samples.usefulness of next-generation sequencing (ngs) in assessing bacteria associated with oral squamous cell carcinoma (oscc) has been undermined by inability to classify reads to the species level.201526426306
arginine-ornithine antiporter arcd controls arginine metabolism and interspecies biofilm development of streptococcus gordonii.arginine is utilized by the oral inhabitant streptococcus gordonii as a substrate of the arginine deiminase system (ads), eventually producing atp and nh3, the latter of which is responsible for microbial resistance to ph stress. s. gordonii expresses a putative arginine-ornithine antiporter (arcd) whose function has not been investigated despite relevance to the ads and potential influence on inter-bacterial communication with periodontal pathogens that utilize amino acids as a main energy sour ...201526085091
fap2 of fusobacterium nucleatum is a galactose-inhibitable adhesin involved in coaggregation, cell adhesion, and preterm birth.fusobacterium nucleatum is a common oral anaerobe involved in periodontitis that is known to translocate and cause intrauterine infections. in the oral environment, f. nucleatum adheres to a large diversity of species, facilitating their colonization and creating biological bridges that stabilize the multispecies dental biofilm. many of these interactions (called coadherences or coaggregations) are galactose sensitive. galactose-sensitive interactions are also involved in the binding of f. nucle ...201525561710
fusobacterium nucleatum: a rare cause of pyogenic liver abscess.while pyogenic liver abscesses are uncommon, they are associated with significant mortality and morbidity. most pyogenic liver abscesses are polymicrobial and are caused by enteric bacteria and anaerobes. rarely, mono-microbial infections may occur, typically in immunocompromised individuals. we report the unusual case of a 69 year-old immunocompetent female who developed a pyogenic liver abscess due to fusobacterium nucleatum infection, likely from a dental source. poor oropharyngeal hygiene se ...201526101735
high individuality of respiratory bacterial communities in a large cohort of adult cystic fibrosis patients under continuous antibiotic treatment.routine clinical diagnostics of cf patients focus only on a restricted set of well-known pathogenic species. recent molecular studies suggest that infections could be polymicrobial with many bacteria not detected by culture-based diagnostics.201525671713
extensive identification of bacterial riboflavin transporters and their distribution across bacterial species.riboflavin, the precursor for the cofactors flavin mononucleotide (fmn) and flavin adenine dinucleotide, is an essential metabolite in all organisms. while the functions for de novo riboflavin biosynthesis and riboflavin import may coexist in bacteria, the extent of this co-occurrence is undetermined. the ribm, ribn, rfuabcd and the energy-coupling factor-ribu bacterial riboflavin transporters have been experimentally characterized. in addition, impx, rfnt and ribxy are proposed as riboflavin tr ...201525938806
oral bacteria in placental tissues: increased molecular detection in pregnant periodontitis patients.the objective of this study was to identify the dna of oral bacteria in placental samples from women with and without periodontitis who had or had not had preterm births and/or low birthweight (pb/lbw) neonates.201526259070
antimicrobial activity of protamine against oral microorganisms.protamine is an arginine-rich polycationic protein extracted from sperm cells of vertebrates including fishes such as salmon. the purpose of this study was to investigate the suppressive effects of protamine on the growth of oral pathogens for possible usage in dental materials. minimal inhibitory concentration (mic) and minimal bactericidal concentration (mbc) were determined by the microdilution method. twelve strains of oral viridans streptococci, actinomyces naeslundii, actinomyces odontolyt ...201526699859
[the efficacy of cold-light tooth bleaching on the formation of bacteria biofilm on the enamel surfaces].to evaluate the efficacy of beyond cold-light tooth bleaching on the formation of main cariogenic bacteria biofilm on enamel surfaces.201526166513
[acute mediastinal syndrome caused by spontaneous hemorrhage in the thyroid region]. 20154641445
cytidine 5'-triphosphate synthetase as a target for inhibition by the antitumor agent 3-deazauridine. 20154472653
the long-term preservation of bone marrow. 20154561229
[intravenous strophanthin therapy]. 20154706873
[the present educational conditions of operative dentistry and dental hygienists in north america and europe (author's transl)]. 20154530469
esterase. xviii. biochemical and histochemical investigations of the subcellular location of the non specific esterase. 20154448707
dental health of university students. 20154693204
[evaluation of study programs for public health nurses]. 20154495719
[factors acting on reminiscence]. 20154380790
[problems of prosthesis fitting following amputations of the lower limbs. observations from the lublin province]. 20154755334
[medico-social problems and solutions in relation to juvenile diabetes]. 20154661885
hydrogen exchange in the synthesis of glyceryl ether and in the formation of dihydroxyacetone in tetrahymena pyriformis. 20154631860
[modern concept of the gene]. 20154557090
the differential count of oral leukocytes. 20154502582
[methods for analysis and clinical significance of hemagglutinating penicillin and cephalosporin antibodies. ii]. 20154587770
[letter: hypokalemia during acute dehydratation in children suffering from malnutrition]. 20154459870
[glomangioma of the vulva. a painful benign tumor in the vulva]. 20154349908
[study of the effect of acth preparations]. 20154314648
meeting basic needs of the elderly. 20154355843
mucosal invasion by fusobacteria is a common feature of acute appendicitis in germany, russia, and china.to investigate the geographic occurrence of mucosa-invading fusobacteria in acute appendicitis.201522249094
active invasion of porphyromonas gingivalis and infection-induced complement activation in apoe-/- mice brains.periodontal disease is a polymicrobial inflammatory disease that leads to chronic systemic inflammation and direct infiltration of bacteria/bacterial components, which may contribute to the development of alzheimer's disease. apoe-/- mice were orally infected (n = 12) with porphyromonas gingivalis, treponema denticola, tannerella forsythia, and fusobacterium nucleatum as mono- and polymicrobial infections. apoe-/- mice were sacrificed following 12 and 24 weeks of chronic infection. bacterial gen ...201525061055
fusobacterium nucleatum subspecies identification by matrix-assisted laser desorption ionization-time of flight mass spectrometry.we explored the use of matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof ms) for identification of fusobacterium nucleatum subspecies. maldi-tof ms spectra of five f. nucleatum subspecies (animalis, fusiforme, nucleatum, polymorphum, and vincentii) were analyzed and divided into four distinct clusters, including subsp. animalis, nucleatum, polymorphum, and fusiforme/vincentii. maldi-tof ms with the modified saramis database further correctly identified 28 of ...201525653408
16s rrna based microarray analysis of ten periodontal bacteria in patients with different forms of periodontitis.dna microarray analysis is a computer based technology, that a reverse capture, which targets 10 periodontal bacteria (parocheck) is available for rapid semi-quantitative determination. the aim of this three-year retrospective study was to display the microarray analysis results for the subgingival biofilm samples taken from patient cases diagnosed with different forms of periodontitis. a total of 84 patients with generalized aggressive periodontitis (gap,n:29), generalized chronic periodontitis ...201525638399
fusobacterium detected in colonic biopsy and clinicopathological features of ulcerative colitis in japan.fusobacterium species are part of the gut microbiome in humans, but some species have been recognized as opportunistic pathogens implicated in inflammatory diseases including inflammatory bowel diseases. here, we performed prevalence screening of fusobacterium in ulcerative colitis (uc) in japanese patients.201525102986
[cerebellar abscess due to infection with the anaerobic bacteria fusobacterium nucleatum: a case report].we report a rare case of cerebellar abscess produced by anaerobic bacteria. a 76-year-old man was admitted to our hospital with a history of fever, vomiting, and dizziness lasting 14 days. computed tomography(ct)scan and magnetic resonance images showed the presence of a multiloculated cerebellar abscess with a right subdural abscess. the patient underwent aspiration of the abscess through a suboccipital craniotomy. fusobacterium nucleatum, which is an anaerobic bacteria naturally present in the ...201525672555
changes in microflora in dental plaque from cancer patients undergoing chemotherapy and the relationship of these changes with mucositis: a pilot study.to assess changes in oral microflora in dental plaque from cancer patients within 7 days of the first course of chemotherapy, and the relationship of the changes with mucositis.201525662538
antibacterial efficacy of a cetylpyridinium chloride-based mouthrinse against fusobacterium nucleatum and in vitro plaques.to assess the antimicrobial effects of a fluoride-free and alcohol-free mouthrinse containing 0.075% cpc (test rinse, tr) compared with an otherwise-identical cpc-free control rinse (cr).201526591620
genotype-specific regulation of oral innate immunity by t2r38 taste receptor.the bitter taste receptor t2r38 has been shown to regulate mucosal innate immune responses in the upper airway epithelium. furthermore, snps in t2r38 influence the sensitivity to 6-n-propylthiouracil (prop) and are associated with caries risk/protection. however, no study has been reported on the role of t2r38 in the innate immune responses to oral bacteria. we hypothesize that t2r38 regulates oral innate immunity and that this regulation is genotype-specific. primary gingival epithelial cells c ...201526552761
fusobacterium nucleatum endocarditis presenting as liver and brain abscesses in an immunocompetent patient. 201525588024
microbial diversity of the supra- and subgingival biofilm of healthy individuals after brushing with chlorhexidine- or silver-coated toothbrush bristles.nanoparticulate silver has recently been reported as an effective antimicrobial agent. the aim of this clinical study was to investigate the potential changes on the oral microbiota of healthy individuals after controlled brushing with chlorhexidine- or silver-coated toothbrush bristles. twenty-four healthy participants were enrolled in this investigation and randomly submitted to 3 interventions. all the participants received, in a crossover format, the following toothbrushing interventions: (i ...201525581046
fusobacterium nucleatum: a commensal-turned pathogen.fusobacterium nucleatum is an anaerobic oral commensal and a periodontal pathogen associated with a wide spectrum of human diseases. this article reviews its implication in adverse pregnancy outcomes (chorioamnionitis, preterm birth, stillbirth, neonatal sepsis, preeclampsia), gi disorders (colorectal cancer, inflammatory bowel disease, appendicitis), cardiovascular disease, rheumatoid arthritis, respiratory tract infections, lemierre's syndrome and alzheimer's disease. the virulence mechanisms ...201525576662
one-step purification and porin transport activity of the major outer membrane proteins p2 from haemophilus influenzae, foma from fusobacterium nucleatum and porb from neisseria meningitidis.bacterial porins are major outer membrane proteins that function as essential solute transporters between the bacteria and the extracellular environment. structural features of porins are also recognized by eukaryotic cell receptors involved in innate and adaptive immunity. to better investigate the function of porins, proper refolding is necessary following purification from inclusion bodies [1, 2]. using a single-step size exclusion chromatographic method, we have purified three major porins f ...201525575589
fusobacterium nucleatum: an emerging bug in colorectal tumorigenesis.the human intestinal microbiota is a plethora of diverse microbial species, wherein certain bacteria considered as driver bacteria with procarcinogenic features contribute directly toward colonic epithelium cell damage to initiate colorectal carcinogenesis. however, some bacteria, in particular fusobacterium nucleatum, which is otherwise a normal resident of the oral microflora and a relatively poor colonizer of the healthy gut, have also been considered to play a role in the development of colo ...201525569450
intracanal antibiotic medication for sustained root surface disinfection-a laboratory evaluation.to measure the release of an antibiotic mixture of ciprofloxacin, cerfuroxim and metronidazole (trevitamix, tvm) through human dentine and to assess the growth inhibition of fusobacterium nucleatum.201526966464
myopericarditis associated with fusobacterium nucleatum-caused liver abscess.a wide clinical spectrum of bacteremic disease caused by fusobacterium has been presented in this journal. we wish to extend this spectrum by presenting a case of myopericarditis resulting from a liver abscess caused by f. nucleatum. while f. nucleatum plays an important role in periodontal disease, and has been isolated from skin ulcers, liver abscesses, urinary tract infections, and endocarditis, a single case of f. nucleatum-induced pericarditis is documented in the literature.201525530149
oral gram-negative anaerobic bacilli as a reservoir of β-lactam resistance genes facilitating infections with multiresistant bacteria.many β-lactamases have been described in various gram-negative bacilli (capnocytophaga, prevotella, fusobacterium, etc.) of the oral cavity, belonging to class a of the ambler classification (cepa, cbla, cfxa, csp-1 and tem), class b (cfia) or class d in fusobacterium nucleatum (fus-1). the minimum inhibitory concentrations of β-lactams are variable and this variation is often related to the presence of plasmids or other mobile genetic elements (mges) that modulate the expression of resistance g ...201525465519
association of fusobacterium nucleatum with clinical and molecular features in colorectal serrated pathway.human gut microbiota is being increasingly recognized as a player in colorectal cancers (crcs). evidence suggests that fusobacterium nucleatum (f. nucleatum) may contribute to disease progression and is associated with cpg island methylator phenotype (cimp) and microsatellite instability (msi) in crcs; however, to date, there are no reports about the relationship between f. nucleatum and molecular features in the early stage of colorectal tumorigenesis. therefore, we investigated the presence of ...201525703934
an oral commensal associates with disease: chicken, egg, or red herring?fusobacterium nucleatum might be the cause or consequence of disease in many tissues in and outside the mouth. in this issue of immunity, gur et al. (2015) suggest a new mechanism by which this oral commensal might help cancer cells escape host immunity.201525692696
binding of the fap2 protein of fusobacterium nucleatum to human inhibitory receptor tigit protects tumors from immune cell attack.bacteria, such as fusobacterium nucleatum, are present in the tumor microenvironment. however, the immunological consequences of intra-tumoral bacteria remain unclear. here, we have shown that natural killer (nk) cell killing of various tumors is inhibited in the presence of various f. nucleatum strains. our data support that this f. nucleatum-mediated inhibition is mediated by human, but not by mouse tigit, an inhibitory receptor present on all human nk cells and on various t cells. using a lib ...201525680274
fusobacterium nucleatum osteomyelitis in 3 previously healthy children: a case series and review of the literature.fusobacterium nucleatum is a rare cause of monomicrobial osteomyelitis in children. we describe the cases of 3 children with f. nucleatum osteomyelitis of the distal femoral epiphysis with concurrent septic arthritis and review 6 other cases reported in the literature. our report emphasizes the importance of maintaining a high index of suspicion for anaerobic osteomyelitis, given its atypical presentation and the unique growth requirements of anaerobic bacteria.201526407282
"messieurs, c'est les microbes qui auront le dernier mot": gentlemen, it is the microbes who have the last word (louis pasteur)-fusobacterium nucleatum protect tumors from killing by immune cells.fusobacterium nucleatum is present in colon cancers where it was shown to generate a proinflammatory microenvironment that supports colorectal neoplasia progression. remarkably, alongside with proinflammatory stimulation, fusobacteria also inhibit cytotoxicity of immune cells. thus, it appears as if tumors exploit fusobacteria to generate a favorable proinflammatory and anti-cytotoxic microenvironment.201526405611
berberine may rescue fusobacterium nucleatum-induced colorectal tumorigenesis by modulating the tumor microenvironment.accumulating evidence links colorectal cancer (crc) with the intestinal microbiota. however, the disturbance of intestinal microbiota and the role of fusobacterium nucleatum during the colorectal adenoma-carcinoma sequence have not yet been evaluated.201526397137
oral cavity anaerobic pathogens in biofilm formation on voice prostheses.a polymerase chain reaction (pcr)-based method has been used to identify oral anaerobic pathogens in biofilms on voice prostheses. the purpose of the present study was to determine the location of those pathogens inside the biofilms.201524677258
microbial mucosal colonic shifts associated with the development of colorectal cancer reveal the presence of different bacterial and archaeal biomarkers.epidemiological studies demonstrate a link between gastrointestinal cancers and environmental factors such as diet. it has been suggested that environmental cancer risk is determined by the interaction between diet and microbes. thus, the purpose of this study was to examine the hypothesis that microbiota composition during colorectal cancer (crc) progression might differ depending on the stage of the disease.201524811328
antibacterial and antigelatinolytic effects of satureja hortensis l. essential oil on epithelial cells exposed to fusobacterium nucleatum.the present report examined the effects of essential oils (eos) from satureja hortensis l. and salvia fruticosa m. on the viability and outer membrane permeability of the periodontopathogen fusobacterium nucleatum, a key bacteria in oral biofilms, as well as the inhibition of matrix metalloproteinase (mmp-2 and mmp-9) activities in epithelial cells exposed to such bacteria. membrane permeability was tested by measuring the n-phenyl-1-naphthylamine uptake and bacterial viability by using the comm ...201524404975
preservation of fusobacterium nucleatum and peptostreptococcus anaerobius dna after loss of cell viability.to investigate whether dna from two obligate anaerobes, fusobacterium nucleatum and peptostreptococcus anaerobius, is recoverable after loss of cell viability induced by air exposure.201524611977
functional biomarkers for chronic periodontitis and insights into the roles of prevotella nigrescens and fusobacterium nucleatum; a metatranscriptome analysis.periodontitis is the most prevalent inflammatory disease worldwide and is caused by a dysbiotic subgingival biofilm. here we used metatranscriptomics to determine the functional shift from health to periodontitis, the response of individual species to dysbiosis and to discover biomarkers.201528721234
to cure racism. 20154702083
to cure racism. 20154702083
some hints in using the peripheral nerve stimulator. 20154735983
[studies on conduction speed of sensible nerves in diabetics]. 20154668044
[basic principles for organization of central monitoring of scientific research in the area of medical radiology and roentgenology]. 20154664240
[hematologic indices during pregnancy]. 20154651492
[arteriographic semiotics of metastatic lesions of the liver]. 20154643231
physical signs, apexcardiography, phonocardiography, and systolic time intervals in angina pectoris. 20154635439
[amplitude discriminator with variable levels of discrimination]. 20154649765
[cemented restorations. the substitution crown, with root post, richmond crown type]. 20154610699
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