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oxygen tension modulates the cytokine response of oral epithelium to periodontal bacteria.there is an inverse relationship between pocket depth and pocket oxygen tension with deep pockets being associated with anaerobic bacteria. however, little is known about how the host tissues respond to bacteria under differing oxygen tensions within the periodontal pocket.201020955352
murine fetoplacental infection models. 201020956576
setup of an in vitro test system for basic studies on biofilm behavior of mixed-species cultures with dental and periodontal pathogens.caries and periodontitis are important human diseases associated with formation of multi-species biofilms. the involved bacteria are intensively studied to understand the molecular basis of the interactions in such biofilms. this study established a basic in vitro single and mixed-species culture model for oral bacteria combining three complimentary methods. the setup allows a rapid screening for effects in the mutual species interaction. furthermore, it is easy to handle, inexpensive, and repro ...201020957048
predation of oral pathogens by bdellovibrio bacteriovorus 109j.periodontal diseases are multifactorial infections elicited by a complex of primarily gram-negative bacteria that interact with host tissues and lead to the destruction of the periodontal structures. bdellovibrio bacteriovorus is a gram-negative bacterium that preys upon other gram-negative bacteria. it was previously shown that b. bacteriovorus has an ability to attack and remove surface-attached bacteria or biofilms. in this study, we examined the host specificity of b. bacteriovorus strain 10 ...201021214870
effect of biofilm on the repair bond strengths of composites.composite restorations degrade during wear, but it is unknown how wear affects the composite surface and influences composite-to-composite bonding in minimally invasive repair. here, it is hypothesized that in vitro exposure of composites to oral biofilm yields clinically relevant degradation of composite surfaces, and its influence on composite-to-composite bonding is determined. biofilms on composite surfaces in vitro increased their roughness and decreased filler particle exposure, except for ...201020940354
killing of anaerobic pathogens by predatory bacteria.recently, the predation of bdellovibrio bacteriovorus on a periodontal pathogen has been described. the current study explores the potential antimicrobial activity of a range of predatory bacteria against key periodontal pathogens. a number of representatives from the bdellovibrio, bacteriovorax and peredibacter lineages (called 'balos') were tested for their activity towards a group of key periodontal pathogens and an optimal multiplicity of infection was established. as the oral cavity contain ...201021214872
[the iridocorneo-endothelial syndrome]. 20103224911
role of absorptive and secretory processes in hydration of the airway surface.in the conducting airways, epithelial electrolyte transport processes play an important role in controlling the quantity and the composition of the airway surface solution layer. hydration of the airway surface appears to promote effective mucociliary clearance and to influence the rheology of mucins, and together these factors provide a major mechanism for airway defense. the cellular processes governing absorption and secretion of salt are similar, if not identical, to those that have been des ...20102849352
a study suggesting two kinds of information processing of the sexual response.genital and subjective sexual arousal in response to sexual imagery was studied. in a previous study subjects who were encouraged to process information on sexual stimuli and sexual responses were more sexually aroused than subjects encouraged to process information on sexual stimuli only. in the present study, the reverse effect was found in subjects who had received further verbal training to differentially process information on sexual stimuli or responses. this suggests two different kinds o ...20102818173
continuing medical education. 20102807491
analyzing acute care nursing staff productivity. 20103645457
aids--dental considerations. a 1986 update. 20102946999
habituation of optically evoked blink reflex in mentally retarded adults.this study was done to record the difference in habituation patterns of optically evoked blink reflexes in mentally retarded and normal adults. sets of photic stimuli with fixed interstimulus duration were utilized in normal volunteers and mentally retarded adults. the interstimulus duration decreased with each sequential set. the blink responses were recorded on fibreoptic recording paper. these electrophysiological methods show objectively that the blink responses to light which habituate in n ...20102926795
comparison of the efficacy of four antihistamines in chronic urticaria. 20102907911
burkitt's lymphoma. 20103075349
burkitt's lymphoma. 20103075349
sexual harassment. prevention and legal aspects. 20103471572
[sideropenia: modality and length of therapy]. 20102976346
neuropsychological and neuroradiological correlates in huntington's disease.measurements of cortical and subcortical atrophy were made on ct scans of 34 patients with huntington's disease. significant correlations were found between the bicaudate ratio (bcr) and an eye movement scale (r = 0.44, p less than 0.01), and activities of daily living scale (r = 0.57, p less than 0.001) and the mini-mental state exam (r = 0.49, p less than 0.01). no correlations were found between bcr values and severity of chorea or voluntary motor impairment. a detailed neuropsychological eva ...20102976080
ultrasound in chest disease: 2. lung and mediastinum. 20103060081
ultrasound in chest disease: 2. lung and mediastinum. 20103060081
ultraviolet light-induced yellowing of dental restorative resins. 20102931511
[gustav adolf wehrli: a passionate collector. on the 100th anniversary of the founder of the museum of medical history in zürich]. 20103065885
rheumatoid arthritis and schizophrenia: are they mutually exclusive?the relationship between schizophrenia and rheumatoid arthritis has been explored in a number of studies. it has been claimed that the two disorders are mutually exclusive. review of the literature indicates that the two conditions seldom coexist. the underlying mechanisms responsible for the infrequent coexistence of schizophrenia and rheumatoid arthritis are far from clear. however, various hypotheses have been proposed to explain the negative correlation between the two diseases.20102863874
heckler v. chaney: judicial and administrative regulation of capital punishment by lethal injection.capital punishment by lethal injection, which was expected to be the most safe and effective of available methods, can produce unusually cruel and inhuman death. in heckler v. chaney, inmates sentenced to death by lethal injection, as well as members of both the medical and legal communities, challenged the food and drug administration's (fda) refusal to regulate certain drugs used for capital punishment by lethal injection. by declining to review the fda's nonenforcement decision, the supreme c ...20103836576
[hole-shaped defect in the scapula]. 20102836918
cholinergic function and alpha-bungarotoxin binding in pc12 cells.the cell line pc12, derived from an adrenal chromaffin cell tumor, expresses both ganglionic (c6) acetylcholine receptors (nachr) and an alpha-bungarotoxin (bgt) binding protein of unknown function. we measured nicotinic na+ fluxes of 180-260 nmol/mg protein x min and 0.35-0.8 pmol [125i]bgt binding sites/mg protein; 45-65% of the [125i]bgt binding was to intracellular sites. we blocked ganglionic na+ fluxes with reversible and irreversible inhibitors and tested whether a residual bgt-sensitive ...20102890091
development of a novel multi-triplex qpcr method for the assessment of bacterial community structure in oral populations.gingivitis and dental caries are two of the most predominant diseases in humans. both conditions are easily treated with the removal of the plaque biofilm by brushing or the use of oral hygiene products. in both cases, pathogenic taxa found within the plaque biofilm are the causal agents of the disease. actinomyces naeslundii, fusobacterium nucleatum and prevotalla intermedia have all been implicated in the development of gingivitis, while streptococcus mutans is the main organism associated wit ...201023766283
[national commission on aids. occupational exposure]. 20102956017
hematometra complicating hormone replacement therapy after radiation for cervical carcinoma.hematometra developed in a patient receiving sequential estrogen-progestogen hormone replacement therapy following radiation for cervical carcinoma. diagnosis, treatment and therapeutic recommendations are discussed.20102851962
stimulant-like effects of magnesium on aggression in mice.the effects of magnesium excesses resulting from daily injections of magnesium chloride (mgcl2) were examined on offensive behavior in a resident-intruder situation. male mice tested 5 min post-injection of 15 mg/kg or 30 mg/kg exhibited a significantly greater number of attacks and threats than saline controls; while in mice injected with 125 mg/kg threat and attack behaviors were decreased. no tolerance developed to this decrease which persisted throughout the 15 day injection period. toleranc ...20102880351
long-term experience with terazosin for treatment of mild to moderate hypertension.two hundred twenty-six patients with mild to moderate hypertension were treated with terazosin in an open, multicenter study to determine the drug's long-term efficacy and safety. all patients had previously received terazosin in a short-term study; 66 patients entered from later short-term studies and had experienced a 7 mm hg decrease in supine diastolic blood pressure in response to terazosin. terazosin was administered once or twice daily either alone or in combination with a diuretic and/or ...20102872810
phno [(+)-4-propyl-9-hydroxynaphthoxazine]: a new and effective anti-parkinson's disease agent.phno [(+)-4-propyl-9-hydroxynaphthoxazine] is a chemically novel and highly potent dopamine (d2) receptor agonist without d1 activity. it had significant antiparkinsonism effects when used as open-label monotherapy in ten patients who were hoehn and yahr stage 2 or 3. the standard formulation of phno produced a 3- to 4-hour therapeutic effect in most patients; the response to the time-release formulation lasted up to 10 hours. side effects were similar to those of other dopamine agonists but dys ...20102901697
increased interleukin-1 and modulation of interleukin-2 production by murine macrophages and lymphocytes treated with lf 1695.previous results have demonstrated that lectin-induced t cell proliferation was potentiated or suppressed by lf 1695, a synthetic immunomodulator, depending on the dose used. therefore the activity of this compound was investigated on murine il-1 and il-2 production. adherent peritoneal cells, incubated with lf 1695, could secrete high levels of il-1 with only a slight elevation in intracellular il-1. this effect apparent at 5 and 10 micrograms/ml was linked to a transient state of activation. a ...20103019905
ultrasonographic findings in the livers of patients with lepromatous leprosy.abdominal ultrasonography, including assessment of the liver, spleen, pancreas, great abdominal vessels, and kidneys, was carried out in seven patients with lepromatous leprosy, six patients with tuberculoid leprosy, and 32 healthy congolese controls. abnormal ultrasound findings were predominantly detected in the livers of patients with lepromatous leprosy and included an inhomogeneous echo texture of the hepatic parenchyma in all cases. furthermore, six patients revealed echo-dense, partly irr ...20103084566
increased interleukin-1 and modulation of interleukin-2 production by murine macrophages and lymphocytes treated with lf 1695.previous results have demonstrated that lectin-induced t cell proliferation was potentiated or suppressed by lf 1695, a synthetic immunomodulator, depending on the dose used. therefore the activity of this compound was investigated on murine il-1 and il-2 production. adherent peritoneal cells, incubated with lf 1695, could secrete high levels of il-1 with only a slight elevation in intracellular il-1. this effect apparent at 5 and 10 micrograms/ml was linked to a transient state of activation. a ...20103019905
blood helper/suppressor lymphocyte ratio in sarcoidosis.the blood helper/suppressor ratio was measured in 38 patients with biopsy-proved sarcoidosis. there was no relationship between this peripheral helper/suppressor ratio and the activity of the granulomatous process. this test needs further evaluation before its routine use in assessing activity in sarcoidosis.20102948514
a prospective randomized study of moxalactam versus gentamicin and clindamycin in penetrating abdominal trauma.we conducted a randomized, prospective study of moxalactam versus gentamicin plus clindamycin in 42 patients with penetrating abdominal trauma. patients were randomized to receive intravenously either 2 grams of moxalactam every 12 hours or 80 milligrams of gentamicin every eight hours and 600 milligrams of clindamycin every six hours. antibiotics were administered preoperatively and continued for a minimum of five days if hollow viscus injury occurred. for those without hollow viscus injury, on ...20103726718
deferoxamine induced decreases of lipid peroxides in rheumatoid arthritis.eleven patients with rheumatoid arthritis (ra) were treated with intraarticular deferoxamine or placebo to test the hypothesis that iron chelation decreased hydroxyl radical mediated lipid peroxidation in ra. intraarticular administration of deferoxamine 100 mg resulted in predominantly systemic effects with decreased serum ferritin and decreased serum levels of lipid peroxidation products. similar changes were not detected in synovial fluid at this dose. iron chelation with deferoxamine may pro ...20102822924
influence of n6-methylation of residue a(5) on the conformational behaviour of d(c-c-g-a-a-t-t-c-g-g) in solution studied by 1h-nmr spectroscopy. 1. the duplex form.one- and two-dimensional nmr studies at 300 mhz and 500 mhz were carried out on the two oligonucleotides d(c-c-g-a-a-t-t-c-g-g) and d(c-c-g-a-m6a-t-t-c-g-g) in aqueous solution. nmr spectra were observed at 10 mm sample concentration over the temperature range 273-368 k. assignments are given of the base, h1', h2', h2", h3' and of some h4' resonances, based upon a combination of two-dimensional correlation spectra (cosy) and two-dimensional nuclear overhauser effect spectra (noesy); imino-proton ...20103028800
influence of n6-methylation of residue a(5) on the conformational behaviour of d(c-c-g-a-a-t-t-c-g-g) in solution studied by 1h-nmr spectroscopy. 1. the duplex form.one- and two-dimensional nmr studies at 300 mhz and 500 mhz were carried out on the two oligonucleotides d(c-c-g-a-a-t-t-c-g-g) and d(c-c-g-a-m6a-t-t-c-g-g) in aqueous solution. nmr spectra were observed at 10 mm sample concentration over the temperature range 273-368 k. assignments are given of the base, h1', h2', h2", h3' and of some h4' resonances, based upon a combination of two-dimensional correlation spectra (cosy) and two-dimensional nuclear overhauser effect spectra (noesy); imino-proton ...20103028800
[pathomorphology of femur head "cysts" with advanced degenerative-deforming changes]. 20103816379
[involvement of the lumbosacral trunk during delivery]. 20102950487
diagnosis of leukemic relapse in the pelvic soft tissues of juvenile females.five females with childhood acute lymphocytic leukemia whose disease relapsed in the pelvis were studied. in all five patients, relapse occurred late in the disease process, and all patients had been in complete continuous remission before relapse. intravenous pyelogram and barium enema revealed hydronephrosis or a mass effect on the bladder or rectosigmoid colon. in three patients, sonography established the presence of a clinically palpable mass with involvement of the uterus, ovaries, and pel ...20103084568
[two busulfan-resistant cases of cml (chronic myelogenous leukemia) with good response to alpha-interferon treatment]. 20103481405
scanning electron microscopy in the backscattered electron imaging (bei) mode: applications to clinical hematology.elements of high atomic number backscatter electrons that carry information of cytochemical and of immunocytochemical significance in high resolution scanning electron microscopy (sem). reaction products of enzyme cytochemistry containing lead or osmium have been used to localize the sites of phosphatase and of endogenous peroxidase, respectively. particles of colloidal gold, ranging in diameter from 40 to 13 nm, have been successfully used to label cell surface antigens specifically identified ...20103318064
predictors of dental behavior of disabled children. 20102978580
changing concepts in mutation research. 20103018767
[ultrastructural and immunohistochemical studies on pleomorphic adenoma and clear cell adenoma arising from salivary gland]. 20102855893
minimal dose (1.25 micrograms) hepatitis b vaccine for infants and newborn babies, 4 years later. 20102891963
polymorphonuclear leukocyte inhibition by therapeutic concentrations of theophylline is mediated by cyclic-3',5'-adenosine monophosphate.although theophylline has been used for many years as a principal agent in treatment of reversible obstructive airway disease, the mechanism of drug activity at therapeutic concentrations remains unclear. because inflammatory mediators generated by polymorphonuclear leukocytes (pmn) may be important in the pathogenesis of airway hyperreactivity, the effects of theophylline upon pmn activation were studied. theophylline (9 micrograms/ml, 50 microm) inhibited pmn leukotriene b4 generation by 50%, ...20102827546
uses of calcium channel blocking agents and beta blocking agents in the control of supraventricular arrhythmias. 20102902640
adapting theory z to nursing management. 20103645461
race, parental history of hypertension, and patterns of cardiovascular reactivity in women.this study examined the interaction of race and parental history of hypertension on patterns of cardiovascular responses among women. two stressors were used that produce different patterns of cardiovascular reactivity: mental arithmetic, primarily a beta-adrenergic stimulus, and the cold face stimulus, which evokes alpha-adrenergic (i.e. vascular) activity. systolic and diastolic blood pressure, heart rate, forearm blood flow, and forearm vascular resistance were assessed before, during, and af ...20102922455
physical mechanism for inactivation of metallo-enzymes by characteristic x-rays.measurements have been made of the inactivation of the metallo-enzyme dihydro-oratic dehydrogenase in solution by characteristic x-rays at energies above and below the k absorption edge of the constituent iron atom. from the dose-survival curves and knowledge of the equilibrium electron spectrum generated by the x-ray 'field', inactivation cross-sections are deduced and expressed in terms of intrinsic efficiencies for the various proposed direct and indirect mechanisms of inactivation. it is con ...20103019913
changes in neurotransmitter release at a neuromuscular junction of the lobster caused by cannabinoids.in vitro intracellular recording techniques were used on an excitatory neuromuscular junction of a walking-limb stretcher muscle of the lobster in order to define the synaptic pharmacology of delta-9-tetrahydrocannabinol (thc), 11-hydroxy-thc and cannabidiol. delta-9-tetrahydrocannabinol and 11-hydroxy-thc, in relatively small concentrations, increased the amplitude of the excitatory junctional potential and the mean quantum content of a muscle fiber, whereas larger concentrations produced depre ...20102901683
[effect of cyclophosphamide on serum complement in mice]. 20102955665
alopecia after immunoglobulin infusion. 20102884527
eicosapentaenoic and dihomo-gamma-linolenic acids. 20102885501
[the obstetrical record]. 20103209837
physical mechanism for inactivation of metallo-enzymes by characteristic x-rays.measurements have been made of the inactivation of the metallo-enzyme dihydro-oratic dehydrogenase in solution by characteristic x-rays at energies above and below the k absorption edge of the constituent iron atom. from the dose-survival curves and knowledge of the equilibrium electron spectrum generated by the x-ray 'field', inactivation cross-sections are deduced and expressed in terms of intrinsic efficiencies for the various proposed direct and indirect mechanisms of inactivation. it is con ...20103019913
monitoring uterine activity at home. 20102916595
[treatment tactics in fractures of the midfoot].metatarsal fractures can occur as isolated lesions in combination with injuries of the ipsilateral tarsus, or in chain injuries of the lower extremity, or within a polytrauma. the choice of surgical or conservative therapy depends significantly on localisation and dislocation of the fracture (especially the involvement of the metatarsus i or v), as well as on the extent of the primary or expected soft part damage. from 1974 to 1984, 137 patients with metatarsal fractures were treated as in patie ...20102879425
correction of iatrogenic floating toe following resection of the base of the proximal phalanx.for many decades, resecting the base of the proximal phalanx was a popular method of correcting hammertoes. the long-term result of the procedure, however, is a flail, proximally retracted, "floating" toe. correction of this challenging surgical problem can be accomplished with a v-y advancement flap and specific releases.20102937523
[various aspects of the etiology and pathogenesis of endocervicosis]. 20102935043
survey of dental school policies on the management of patients with hepatitis b or aids. 20102963608
[clinical trials in norway]. 20102916210
[value of computerized tomography in the evaluation of the operability of bronchial cancers].65 computer tomographs were taken of 79 patients with bronchial carcinoma for the purpose of determining operability. included were 49 computer tomographs of the thoracic region, 7 of the epigastrium, and 9 of the skull. ct, a noninvasive radiological diagnostic method, was used in the above cases not only for diagnosis but even more for high-accuracy staging and thus therapy planning. ct accuracy regarding assessment of local operability amounted to 97.9 per cent (n = 49). there was only one ca ...20103020839
sample contamination by test strips. 20103815807
[atypical variant of cushing's syndrome]. 20102897495
hepatitis b, tropical ulcers, and immunisation strategy in kiribati.the seroepidemiology of hepatitis b was studied in kiribati (formerly the gilbert islands). six hundred and two (98%) of the population studied showed evidence of current or previous infection. the prevalence of hepatitis b surface antigen was 31% (188/615) and of the e antigen was 9% (58/615). infection was acquired early in life, and the prevalence of both antigens declined with age. the rates of infection were similar in all age groups examined (0-70) including early childhood. both hepatitis ...20103103763
[screening for tetracyclic benzodiazepines using emit-st (benzodiazepines) and tdx].the article reports threshold ranges and detection limits for the screening of tetracyclic benzodiazepines (adinazolam, alprazolam, brotizolam, estazolam, loprazolam, midazolam, triazolam and many metabolites) using the emit-st and tdx system (fpia). in most cases, the cross reactivities of the two systems are comparable, but there are also remarkable differences. detection limits are mainly in the range between 0.2 and 0.5 mg/l but, in some cases, the limits are also considerably higher. the wi ...20102893500
hyperresponsiveness to water immersion in sodium retaining cirrhotics: the role of atrial natriuretic factor.cirrhotics do not respond uniformly to head-out water immersion (hwi). some cirrhotics have an exaggerated natriuresis while others are unresponsive. we studied the humoral and urinary responses to hwi in 5 cirrhotics and compared this to 5 normals on the same 20 mm sodium intake. these cirrhotics had a documented tendency to salt and water retention but had minimal or no evidence of significant ascites. plasma levels of atrial natriuretic factor (anf) increased during immersion in both groups. ...20102976331
bone marrow under attack. 20102863550
the versatility of hydroxyapatite blocks in maxillofacial surgery.there is considerable interest at present in the potential role of calcium hydroxyapatite as a biomaterial for bone augmentation in oral and maxillofacial surgery. most of the published work has been on the particulate form, mainly in alveolar ridge procedures. however, hydroxyapatite is also available as solid or porous blocks. the blocks are more predictable in their use than are the particles, and are adaptable and versatile. this paper reviews the biological behaviour of the material and dis ...20102825758
enzymic capacities of amyloplasts from wheat (triticum aestivum) endosperm.lysates of protoplasts from the endosperm of developing grains of wheat (triticum aestivum) were fractionated on density gradients of nycodenz to give amyloplasts. enzyme distribution on the gradients suggested that: (i) starch synthase and adp-glucose pyrophosphorylase are confined to the amyloplasts; (ii) pyrophosphate: fructose-6-phosphate 1-phosphotransferase and udp-glucose pyrophosphorylase are confined to the cytosol; (iii) a significant proportion (23-45%) of each glycolytic enzyme, from ...20102849412
nucleic acid sandwich hybridization in detection of hpv 16 dna: technique and its clinical application.nucleic acid sandwich hybridization technique was used for detection of hpv 16 specific dna in cervical scrapes. alternating hpv 16-psti fragments were cloned into plasmid pbr322 and phage m13mp10. pbr322-clones were used as 32p-labelled probe reagents and the m13mp10 clones as catching reagents in the assay. the detection limit of the test proved to be 1-5 x 10(5) hpv 16 molecules per test. a weak cross reaction was seen with hpv 31 dna but not with the other types tested, e.g. hpv 6, 11, 18 an ...20102832436
the case for case management. 20103108737
separation and function of neutrophil karyogranuloplasts and comparison with cytoplasts and intact cells.since neutrophil cytoplasts lacking nucleus and granules were first prepared by centrifuging neutrophils over a discontinuous ficoll gradient containing cytochalasin b, several functional deficits have been reported in these cytoplasts. although these functional deficits have been considered to originate from the absence of organelles, cell damage during preparation could not be excluded. therefore, in the following experiments the ficoll gradient was modified to isolate both cytoplasts and kary ...20102820878
recurrence risk of neonatal hyperbilirubinemia in siblings.the recurrence of neonatal hyperbilirubinemia (nhb) in full siblings was studied in 3301 live infants born between 1966 and 1986 to 1669 male us army veterans who were part of a nationwide health study. the study population included 580 sibships with one infant, 679 with two, and 410 with three or more. hospital of birth medical records were abstracted on these children. neonatal hyperbilirubinemia was defined as present if the recorded peak bilirubin level was greater than 205 mumol/l in the ab ...20103177302
prenatal ultrasonographic diagnosis of fetal adrenal neuroblastoma. 20103084577
early second-trimester sonographic diagnosis of thoracopagus twins. 20103084572
differentiation of exercise-induced metabolic responses during selective beta 1- and beta 2-antagonism.the effect of beta 1- or beta 2-antagonism on the plasma levels of glucose, lactate, triglycerides, and free fatty acids was studied in seventeen normal male volunteers. all subjects performed three graded and uninterrupted exercise tests until exhaustion. prior to each exercise test they received in a randomized order during three consecutive days either placebo or a predominant beta 1-blocker (atenolol, 50 mg once per day) or a predominant beta 2-blocker (ici 118,551, 20 mg t.i.d.), according ...20103010028
in vitro lipid oxidation modifies proteins and functional properties of sarcoplasmic reticulum.changes in protein and fatty acid compositions of flounder sarcoplasmic reticulum during nadh plus ascorbate-dependent lipid peroxidation in vitro were related to the ability of the sarcoplasmic reticulum to sequester ca+2. progressive accumulation of high-molecular-weight protein components occurred concomitantly with loss of ca+2-sequestering activity. part of this polymerized protein may be the dimer or trimer of ca+2, mg+2-atpase. loss in ca+2, mg+2-atpase protein could account for over 60% ...20102943730
the practice of pharmacy in england.the practice of pharmacy in england is described. community pharmacies have a contract with the department of health and social security to fill national health service prescriptions. a large proportion of the general public obtain their prescriptions free. funding for the health service comes from taxes and automatic contributions from employers and employees. aspects of hospital pharmacy practice and salaries are discussed, e.g., a junior pharmacist may expect to earn between $9000 and $12,000 ...20103769776
[biological functions and time--the loose coupling mechanism of molecular machines]. 20102934765
first international symposium and swiss hypertension workshop on atrial natriuretic peptides. 18-19 november 1985, berne, switzerland. 20102941529
[endocrine therapy of prostatic carcinoma with slow release (depot) formulation of the lh-rh analog ici 118630 (zoladex)].to investigate the clinical efficacy, safety and endocrinology of ici 118630 (zoladex) depot formulation at 3 different dose levels (0.9, 1.8 and 3.6 mg), 90 patients were randomized to receive either one of the 3 doses from april, 1985 to march, 1986 in 28 centers. the depot preparation was injected subcutaneously every 4 weeks 3 times (for up to 12 weeks). clinical efficacy was evaluated in terms of tumor response and overall subjective response. in 70 patients eligible for tumor response eval ...20102967622
the duration of local control of classic (non-aids-associated) kaposi's sarcoma by radiotherapy.we report the short- and long-term responses to radiotherapy of 82 classic kaposi's sarcomas. doses were prescribed ab initio and no attempt was made to discontinue treatment as soon as shrinkage was observed, as has been recommended by others. more than 50% of the lesions regressed completely and nearly all underwent some regression. almost all recurrences were detected within 2 years of treatment and virtually all occurred in lesions that had not regressed completely within 2 weeks of radiothe ...20103403746
sulfasalazine in rheumatoid arthritis. a double-blind, placebo-controlled trial.sulfasalazine (ssz), 3 gm daily, was compared with placebo for treatment of rheumatoid arthritis, in a 15-week randomized, parallel, double-blind trial. joint tenderness and swelling, morning stiffness, grip strength, and pain score all showed significantly more improvement with ssz than with placebo. adverse effects, particularly gastrointestinal reactions, led to withdrawal from the study of 28% of the patients who had been receiving ssz, but these effects were all readily reversible and not l ...20102879544
nephrolithiasis and cholelithiasis in a premature infant. 20103084571
food incentives to improve clinic attendance. 20102873484
autoregulated instability of beta-tubulin mrnas by recognition of the nascent amino terminus of beta-tubulin.tubulin synthesis in animal cells is controlled by an autoregulatory mechanism that modulates the stability of polysome-bound tubulin messenger rnas. the beta-tubulin rnas are selectively targeted as substrates for destabilization not through the recognition of specific rna sequences, but rather through co-translational recognition of the amino-terminal beta-tubulin tetrapeptide after its emergence from the ribosome. this motif is likely to be used in other systems where rna degradation is coupl ...20103405308
surgical treatment for tetralogy of fallot: a quarter of a century of progress. 20104130208
effect of growth state, tumor promoters, and transformation upon intercellular communication between c3h/10t1/2 murine fibroblasts.diminished intercellular communication has been associated with heightened sensitivity of cultured cells to morphological transformation and enhancement of transformation by tumor promoters. microinjection of lucifer yellow dye was employed to evaluate intercellular communication between transformable c3h/10t1/2 murine fibroblasts under a variety of culture conditions. intercellular communication assayed by dye transfer from injected cells to surrounding cells in contact occurred in logarithmica ...20102910519
[management of degenerative changes in the femoro-patellar joint]. 20102863426
[a case of hepatocellular carcinoma with intratumoral gas formation detected by plain abdominal x-ray film]. 20102846919
cystic intracerebellar epidermoids with rim enhancement. a case report.a case of two infected cystic epidermoids of the right cerebellar hemisphere is reported. one of the cysts showed peripheral contrast enhancement on ct. relevant literature regarding the pathogenesis and ct diagnosis is reviewed.20103665295
normal immune response to hepatitis b vaccine in patients with down's syndrome. a basis for immunization guidelines.institutionalized patients with down's syndrome (ds) are uniquely predisposed to develop chronic hepatitis b infection following exposure. therefore vaccination is particularly warranted, but there have been concerns that these individuals may react suboptimally. we examined the immune responses of 62 institutionalized patients with ds to 20 and 40 micrograms of hepatitis b vaccine inactivated (heptavax-b) over one year. the subjects were matched by weight, age, and sex. seroconversion rates and ...20102933533
ovarian failure after high-dose melphalan in adolescents. 20102884506
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