Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| polyarteritis nodosa and familial mediterranean fever. | a 22-year-old familial mediterranean fever (fmf) patient was hospitalized for continuous fever, myalgia, hypertension, vertigo and a petechial rash. laboratory findings revealed hyperglobulinaemia, thrombocytosis and a leukaemoid reaction. while on steroid therapy the patient sustained a haemorrhage into a renal aneurysm which responded to gel foam embolization. after 12 months of follow-up his condition remained stable under treatment with cyclophosphamide, prednisone and antihypertensive medic ... | 2009 | 2881591 |
| polyarteritis nodosa and familial mediterranean fever. | a 22-year-old familial mediterranean fever (fmf) patient was hospitalized for continuous fever, myalgia, hypertension, vertigo and a petechial rash. laboratory findings revealed hyperglobulinaemia, thrombocytosis and a leukaemoid reaction. while on steroid therapy the patient sustained a haemorrhage into a renal aneurysm which responded to gel foam embolization. after 12 months of follow-up his condition remained stable under treatment with cyclophosphamide, prednisone and antihypertensive medic ... | 2009 | 2881591 |
| second international symposium on new quinolones. geneva, switzerland, 25-27 august 1988. | 2009 | 2772475 | |
| thalidomide for graft-versus-host disease. | 2009 | 2903342 | |
| haemorrhagic pulmonary oedema ("massive pulmonary haemorrhage") in the newborn. | 2009 | 4180098 | |
| [empirical antimicrobial therapy of infection and fever episodes in children and adolescents with neutropenia caused by cytotoxic chemotherapy]. | the experience with empirical antimicrobial therapy of septicemia and febrile episodes in pediatric neutropenic patients was analyzed retrospectively. between january 1985 and march 1988 in 49 patients 77 episodes were observed. bacteremia was found in 15 (20%), culture proven localized bacterial infection in 11 (14%) and clinically diagnosed bacterial infection was found in 7 (9%) of the febrile episodes. thus, 33 (43%) documented bacterial infections were observed. for initial therapy a combin ... | 2009 | 2717190 |
| o-dealkylation and acetylation of sulfamethomidine by the snail cepaea hortensis. | 2009 | 2810486 | |
| new bacterial compositions in root-filled teeth with periradicular lesions. | the aim of this study was to isolate and detect microorganisms of root-filled teeth associated with periradicular lesions. specimens were sampled from patients undergoing root canal retreatment. the bacteria were characterized by morphologic and biochemical analysis and by 16s rrna gene sequencing. microorganisms were detected in 10 of 18 teeth. the majority of positive samples revealed a mixed culture of 2-8 species. in 2 teeth enterococcus faecalis was the only detected species. for the first ... | 2009 | 19166766 |
| coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch. | the biosynthesis of several protein cofactors is subject to feedback regulation by riboswitches. flavin mononucleotide (fmn)-specific riboswitches, also known as rfn elements, direct expression of bacterial genes involved in the biosynthesis and transport of riboflavin (vitamin b(2)) and related compounds. here we present the crystal structures of the fusobacterium nucleatum riboswitch bound to fmn, riboflavin and antibiotic roseoflavin. the fmn riboswitch structure, centred on an fmn-bound six- ... | 2009 | 19169240 |
| toll-like receptor 2 and nalp2 mediate induction of human beta-defensins by fusobacterium nucleatum in gingival epithelial cells. | we previously reported that infection by fusobacterium nucleatum strongly induced the expression of both human beta-defensin 2 (hbd-2) and hbd-3 by gingival epithelial cells. the aim of this study was to characterize the pattern recognition receptors (prrs) and regulatory mechanisms involved in the induction of hbd-2 and -3 expression by f. nucleatum in gingival epithelial cells. immortalized human gingival epithelial hok-16b cells were infected with live or heat-killed f. nucleatum, and the exp ... | 2009 | 19103770 |
| [preliminary study on the discrimination of putative periodontal pathogens with a metabonomics method]. | to evaluate the feasibility of identifying oral pathogenic bacteria by comparing the metabolic profiling of putative periodontal pathogens and try to find a convenient and rapid way to discriminate oral microorganisms. | 2009 | 19637485 |
| bone microbial contamination influences autogenous grafting in sinus augmentation. | the oral occurrence of putative microbial pathogens in humans has been documented in health and disease. the presence of periodontopathogens in patients with a history of periodontal disease may have a negative impact on bone regeneration. this investigation was conducted to confirm the presence of periodontal pathogens in bone particles harvested intraorally for maxillary sinus augmentation and to assess the clinical and radiographic outcomes 6 to 12 months after bone augmentation. | 2009 | 19656037 |
| quantitative detection of periodontopathic bacteria in atherosclerotic plaques from coronary arteries. | oral pathogens, including periodontopathic bacteria, are thought to be aetiological factors in the development of cardiovascular disease. in this study, the presence of aggregatibacter actinomycetemcomitans, fusobacterium nucleatum-periodonticum-simiae group, porphyromonas gingivalis, prevotella intermedia, prevotella nigrescens and tannerella forsythia in atheromatous plaques from coronary arteries was determined by real-time pcr. forty-four patients displaying cardiovascular disease were submi ... | 2009 | 19679682 |
| assessment of intraradicular bacterial composition by terminal restriction fragment length polymorphism analysis. | the aim of the study was to assess the bacterial community structures associated with endodontic infections using terminal restriction fragment length polymorphism (t-rflp), and to investigate the correlation of whole community profiles with the manifestation of particular clinical features. | 2009 | 19702949 |
| oral bacteria induce a differential activation of human immunodeficiency virus-1 promoter in t cells, macrophages and dendritic cells. | the human immunodeficiency virus (hiv) can integrate into t cells, macrophages and dendritic cells resulting in a latent infection. reports have also demonstrated that various microbial and host cell factors can trigger hiv reactivation leading to hiv recrudescence, potentially undermining highly active antiretroviral therapies. | 2009 | 19702954 |
| the effect of lactoferrin on oral bacterial attachment. | lactoferrin (lf), an iron-binding salivary glycoprotein, plays an important role in human innate defense against local mucosal infection. we hypothesized that lf interferes with initial oral bacterial attachment to surfaces by iron sequestration, so inhibiting subsequent biofilm formation. the objective was to investigate the effect of lf on the early stages of single-species and multi-species oral biofilm development. | 2009 | 19702956 |
| contemporary root canal irrigants are able to disrupt and eradicate single- and dual-species biofilms. | clinical/microbiological studies have consistently revealed the persistence of some bacteria after conventional root canal debridement. although this was originally attributed to the complexity of the root canal anatomy and the difficulty of delivering antibacterial agents effectively, it has emerged that the biofilm encasement of bacterial cells may confer a further mechanism of resistance. the purpose of this study was to investigate the relative disruption and bactericidal effects of root can ... | 2009 | 19720223 |
| maternal periodontal disease and soluble fms-like tyrosine kinase-1 expression. | this study was conducted to examine the relationship between maternal periodontal disease and plasma angiogenic factor expression of soluble fms-like tyrosine kinase (sflt)-1. | 2009 | 19722802 |
| fusobacterium nucleatum endocarditis mimicking polymyalgia rheumatica. | a case of fusobacterium nucleatum endocarditis in an 80-year-old man is reported. the patient presented with a headache and nonspecific musculoskeletal symptoms and was misdiagnosed as having polymyalgia rheumatica. the diagnosis of bacterial endocarditis was delayed because of an insidious presentation, typical in infections with low virulence micro-organisms. the musculoskeletal symptoms, unresponsive to protracted corticosteroids, completely resolved with intravenous ampicillin treatment. rhe ... | 2009 | 19738533 |
| mutualistic biofilm communities develop with porphyromonas gingivalis and initial, early, and late colonizers of enamel. | porphyromonas gingivalis is present in dental plaque as early as 4 h after tooth cleaning, but it is also associated with periodontal disease, a late-developing event in the microbial successions that characterize daily plaque development. we report here that p. gingivalis atcc 33277 is remarkable in its ability to interact with a variety of initial, early, middle, and late colonizers growing solely on saliva. integration of p. gingivalis into multispecies communities was investigated by using t ... | 2009 | 19749049 |
| the impact of the stone age diet on gingival conditions in the absence of oral hygiene. | the objective of this study was to assess the oral microbiota and clinical data in subjects without access to traditional oral hygiene methods and who ate a diet available in the stone age. | 2009 | 19405829 |
| decreased interleukin-2 responses to fusobacterium nucleatum and porphyromonas gingivalis in generalized aggressive periodontitis. | compromised t-cell responses to periodontal pathogens may contribute to the pathogenesis of generalized aggressive periodontitis (gagp). in this study, we attempted to characterize t-helper cell (th1, th2, and th17) responses in patients with gagp and healthy controls upon stimulation with disease-relevant pathogens. | 2009 | 19405834 |
| tgf-beta1 inhibits tlr-mediated odontoblast responses to oral bacteria. | tgf-beta1 exerts diverse functions in tooth development and tissue repair, but its role in microbial defenses of the tooth is not well-understood. odontoblasts extending their cellular processes into the dentin are the first cells to recognize signals from tgf-beta1 and bacteria in carious dentin. this study aimed to determine the role of tgf-beta1 in modulating odontoblast responses to oral bacteria. we show that these responses depend upon the expression levels of microbial recognition recepto ... | 2009 | 19407153 |
| multi-species biofilm formation on dental materials and an adhesive patch. | this laboratory study assessed the influence of surface roughness and contact time on the formation of a multi-species biofilm on dental materials (adhesive patch, composite, amalgam and enamel). | 2009 | 19408815 |
| human cytomegalovirus and epstein-barr virus inhibit oral bacteria-induced macrophage activation and phagocytosis. | periodontal disease is an inflammatory condition caused by periodontal microorganisms. viruses such as human cytomegalovirus (hcmv) and epstein-barr virus (ebv) are associated with certain types of periodontal disease, but their roles in promoting the disease are unclear. because both viruses infect human macrophages, cells which play key roles in the clearance of pathogenic bacteria, it is likely that the viruses alter the functional capacity of macrophages by inhibiting their defense mechanism ... | 2009 | 19416455 |
| polymicrobial infections, biofilms, and beyond. | 2009 | 19419439 | |
| mouse model of experimental periodontitis induced by porphyromonas gingivalis/fusobacterium nucleatum infection: bone loss and host response. | to compare the effect of oral infection with porphyromonas gingivalis or fusobacterium nucleatum versus infection with both bacteria on mouse periodontal tissues, and to characterize the inflammatory response. | 2009 | 19419440 |
| bacteria in the apical root canal of teeth with primary apical periodontitis. | bacteria settled in the apical root canal are in a privileged position to inflict damage to the periradicular tissues. therefore, the species identified in this region can be of special relevance for the pathogenesis of apical periodontitis. this study investigated the occurrence and levels of several bacterial taxa in the apical root canal of teeth with apical periodontitis. | 2009 | 19426923 |
| proteomics of porphyromonas gingivalis within a model oral microbial community. | porphyromonas gingivalis is a periodontal pathogen that resides in a complex multispecies microbial biofilm community known as dental plaque. confocal laser scanning microscopy showed that p. gingivalis can assemble into communities in vitro with streptococcus gordonii and fusobacterium nucleatum, common constituents of dental plaque. whole cell quantitative proteomics, along with mutant construction and analysis, were conducted to investigate how p. gingivalis adapts to this three species commu ... | 2009 | 19454014 |
| methods for optimizing dna extraction before quantifying oral bacterial numbers by real-time pcr. | methods for the optimal extraction of genomic dna for real-time pcr enumeration of oral bacteria using the muramidase, mutanolysin, were developed using a simple in vitro oral flora model comprised of the facultative anaerobic gram-positive bacteria, lactobacillus acidophilus and streptococcus mutans, the gram-positive anaerobe, parvimonas micra, and the gram-negative anaerobes, porphyromonas gingivalis, prevotella melaninogenica and fusobacterium nucleatum. traditional, as well as more elaborat ... | 2009 | 19459962 |
| fusobacterium nucleatum, the first gram-negative bacterium demonstrated to produce polyglutamate. | poly-gamma-glutamate has been described in many gram-positive organisms. when anchored to the surface, it is a capsule and as such a virulence factor. based on sequence similarities, few gram-negative organisms have been suggested to synthesize poly-gamma-glutamate. for the first time, a gram-negative bacterium, fusobacterium nucleatum, is shown to produce and secrete poly-gamma-glutamate. putative poly-gamma-glutamate-synthesizing genes from gram-negative organisms have been compared with their ... | 2009 | 19483793 |
| fetal exposure to oral pathogens and subsequent risk for neonatal intensive care admission. | maternal periodontal infection has been associated with adverse maternal and neonatal outcomes. in utero fetal exposure to oral pathogens was also recognized as deleterious to the fetus. the objective of this study was to determine the relationship between fetal exposure to oral pathogens and neonatal intensive care unit (nicu) admission. | 2009 | 19485816 |
| systemic immune responses in pregnancy and periodontitis: relationship to pregnancy outcomes in the obstetrics and periodontal therapy (opt) study. | our previous studies reported on the obstetric, periodontal, and microbiologic outcomes of women participating in the obstetrics and periodontal therapy (opt) study. this article describes the systemic antibody responses to selected periodontal bacteria in the same patients. | 2009 | 19485826 |
| [detection of luxs gene of quorum sensing signal system in periodontal pathogen]. | to detect the presence and distribution of luxs gene in quorum sensing signal system in the periodontal pathogens. | 2009 | 19489256 |
| a 21-year-old man with fever and abdominal pain after recent peritonsillar abscess drainage. | lemierre syndrome an extremely rare and unreported disease typically results from oropharyngeal infection and/or local tissue trauma with invasion of the parapharyngeal soft tissue with bacteria. once local tissue invasion occurs, internal jugular vein septic thrombophlebitis with or without metastatic complications may occur. the etiology of lemierre syndrome is generally fusobacterium necrophorum, reported to be present in approximately 80% of the cases. the outcome of lemierre syndrome in the ... | 2009 | 19555636 |
| real-time polymerase chain reaction to determine the prevalence and copy number of epstein-barr virus and cytomegalovirus dna in subgingival plaque at individual healthy and periodontal disease sites. | detection of cytomegalovirus (cmv) and epstein-barr virus (ebv) in plaque from patients with periodontal disease provides support for the theory that these viruses play a role in the pathogenesis of periodontitis. this study sought to further define this relationship by determining the prevalence of these viruses at individual disease and healthy sites of patients with periodontal disease and to determine whether the presence and amount of viral dna correlate with disease severity. | 2009 | 19563294 |
| fusobacterium nucleatum enters normal human oral fibroblasts in vitro. | fusobacterium nucleatum, a commensal opportunistic oral bacterium, is capable of invading gingival epithelial cells, but the entrance into human primary oral fibroblast cells has not been documented. this study evaluated the ability of three strains of f. nucleatum (f. nucleatum ssp. nucleatum, f. nucleatum ssp. polymorphum, and f. nucleatum ssp. vincentii) to enter gingival fibroblasts (gfs) and periodontal ligament fibroblasts (plfs). | 2009 | 19563299 |
| comparison between polymerase chain reaction-based and checkerboard dna hybridization techniques for microbial assessment of subgingival plaque samples. | to compare polymerase chain reaction (pcr) with subsequent reverse hybridization (micro-ident test) and checkerboard dna-dna hybridization for the identification of 13 bacterial species in subgingival plaque samples. | 2009 | 19563330 |
| aggregatibacter actinomycetemcomitans builds mutualistic biofilm communities with fusobacterium nucleatum and veillonella species in saliva. | human oral bacterial pathogens grow in attached multispecies biofilm communities. unattached cells are quickly removed by swallowing. therefore, surface attachment is essential for growth, and we investigated multispecies community interactions resulting in mutualistic growth on saliva as the sole nutritional source. we used two model systems, saliva-coated transferable solid-phase polystyrene pegs (peg biofilms) and flow cells with saliva-coated glass surfaces. fluorescent antibody staining and ... | 2009 | 19564387 |
| proteomic analysis of endodontic infections by liquid chromatography-tandem mass spectrometry. | endodontic infections are very prevalent and have a polymicrobial etiology characterized by complex interrelationships between endodontic microorganisms and the host defenses. proteomic analysis of endodontic infections can provide global insights into the invasion, pathogenicity mechanisms, and multifactorial interactions existing between root canal bacteria and the host in the initiation and progression of apical periodontitis. the purpose of this study was to apply proteomic techniques such a ... | 2009 | 19572900 |
| microbial interactions influence inflammatory host cell responses. | the inflammatory response plays an important role in the tissue destruction associated with periodontitis. bacterial species can regulate the inflammatory responses of host cells, triggered by pathogens. it was hypothesized that, in the field of oral microbiology/immunology, such effects of bacterial interactions on inflammatory host cell responses might also be present. in this study, the effects of beneficial, commensal, and pathogenic species on aggregatibacter actinomycetemcomitans-induced i ... | 2009 | 19828891 |
| involvement of cytosolic phospholipase a2alpha in mmp-9 up-regulation. | matrix metalloproteinase-9 (mmp-9) is important in the pathogenesis of periodontitis. cytosolic phospholipase a(2)alpha (cpla(2)alpha) is involved in mmp-9 up-regulation in human monocytes. we tested the hypothesis that cpla(2)alpha also regulates mmp-9 induction by fusobacterium nucleatum and by phorbol 12-myristate-13-acetate (pma) in gingival epithelial cells. while pma induced mmp-9 expression considerably, f. nucleatum did so moderately. this time-course study demonstrated that mmp-9 mrna u ... | 2009 | 19828892 |
| progression of chronic periodontitis can be predicted by the levels of porphyromonas gingivalis and treponema denticola in subgingival plaque. | chronic periodontitis is an inflammatory disease of the supporting tissues of the teeth associated with bacteria. diagnosis is achieved retrospectively by clinical observation of attachment loss. predicting disease progression would allow for targeted preventive therapy. the aim of this study was to monitor disease progression in patients on a maintenance program and determine the levels of specific bacteria in subgingival plaque samples and then examine the ability of the clinical parameters of ... | 2009 | 19832799 |
| characterization of bacterial flora in persistent apical periodontitis lesions. | microorganisms are able to survive and induce persistent infection in periapical tissues. the aim of this study was to investigate the composition of the microflora of persistent apical periodontitis lesions. | 2009 | 19832803 |
| autoaggregation response of fusobacterium nucleatum. | fusobacterium nucleatum is a gram-negative oral bacterial species associated with periodontal disease progression. this species is perhaps best known for its ability to adhere to a vast array of other bacteria and eukaryotic cells. numerous studies of f. nucleatum have examined various coaggregation partners and inhibitors, but it is largely unknown whether these interactions induce a particular genetic response. we tested coaggregation between f. nucleatum atcc strain 25586 and various species ... | 2009 | 19837836 |
| antibiotic resistance of periodontal pathogens obtained from frequent antibiotic users. | the occurrence of bacterial strains resistant to different antimicrobials is a growing problem in latin american countries. the aim was to measure the antimicrobial susceptibility of fusobacterium nucleatum, prevotella intermedia and prophyromona gingivalis, isolated from chronic periodontitis patients. twenty-five patients diagnosed with generalized- moderate or advanced- chronic periodontitis were consecutively recruited from patients attending the periodontal specialist program, javeriana uni ... | 2009 | 19839485 |
| hydrogen sulfide production from cysteine and homocysteine by periodontal and oral bacteria. | hydrogen sulfide is one of the predominant volatile sulfur compounds (vscs) produced by oral bacteria. this study developed and evaluated a system for detecting hydrogen sulfide production by oral bacteria. | 2009 | 19905954 |
| starvation response and growth in serum of fusobacterium nucleatum, peptostreptococcus anaerobius, prevotella intermedia, and pseudoramibacter alactolyticus. | the microbiota inhabiting the untreated root canal differ markedly from those found in post-treatment disease, yet there is limited information on the microbial characteristics distinguishing the different infections. we hypothesized that starvation survival is a key microbial property in species selection. this study analyzed starvation-survival behavior over 60 days of species representative of the untreated root canal infection: fusobacterium nucleatum, peptostreptococcus anaerobius, prevotel ... | 2009 | 19540450 |
| bacterial colonization of enamel in situ investigated using fluorescence in situ hybridization. | oral biofilms are one of the greatest challenges in dental research. the present study aimed to investigate initial bacterial colonization of enamel surfaces in situ using fluorescence in situ hybridization (fish) over a 12 h period. for this purpose, bovine enamel slabs were fixed on buccal sites of individual splints worn by six subjects for 2, 6 and 12 h to allow biofilm formation. specimens were processed for fish and evaluated with confocal laser-scanning microscopy, using probes for eubact ... | 2009 | 19528150 |
| purification and partial characterization of a bacteriocin produced by an oral fusobacterium nucleatum isolate. | to purify and partially characterize a bacteriocin produced by a fusobacterium nucleatum strain. | 2009 | 19426276 |
| complementation of the fada mutation in fusobacterium nucleatum demonstrates that the surface-exposed adhesin promotes cellular invasion and placental colonization. | fusobacterium nucleatum is a gram-negative oral anaerobe implicated in periodontal disease and adverse pregnancy outcome. the organism colonizes the mouse placenta, causing localized infection and inflammation. the mechanism of placental colonization has not been elucidated. previous studies identified a novel adhesin from f. nucleatum, fada, as being involved in the attachment and invasion of host cells. the fada deletion mutant f. nucleatum 12230 us1 was defective in host cell attachment and i ... | 2009 | 19398541 |
| evidence for pseudoknot formation of class i preq1 riboswitch aptamers. | all in a knot. the smallest riboswitch forms a pseudoknot in solution. this is demonstrated for preq(1) class i aptamers by mutational analysis in combination with (1)h nmr-based structure probing. how pseudoknot formation mediates the mrna response through its expression platform is now open for investigation. | 2009 | 19382115 |
| a novel vaccine targeting fusobacterium nucleatum against abscesses and halitosis. | an abscess in a gum pocket, resulting from bacterial infection, is a common source of chronic halitosis. although antibiotics are generally prescribed for abscesses, they require multiple treatments with risks of creating resistant bacterial strains. here we develop a novel vaccine using ultraviolet-inactivated fusobacterium nucleatum (f. nucleatum), a representative oral bacterium for halitosis. a gum pocket model, established by continuous inoculation of f. nucleatum, was employed to validate ... | 2009 | 19162109 |
| tinidazole inhibitory and cidal activity against anaerobic periodontal pathogens. | the in vitro activity of tinidazole against anaerobic periodontal pathogens (25 prevotella buccae, 18 prevotella denticola, 10 prevotella intermedia, 6 prevotella melaninogenica, 5 prevotella oralis, 10 fusobacterium nucleatum and 8 veillonella spp.) was determined by agar dilution. mic(90) values (minimum inhibitory concentration for 90% of the organisms) were 8 microg/ml for veillonella spp., 4 microg/ml for p. intermedia, 2 microg/ml for p. buccae, 1 microg/ml for fusobacterium spp. and 0.5 m ... | 2009 | 19097755 |
| crystal structure of fada adhesin from fusobacterium nucleatum reveals a novel oligomerization motif, the leucine chain. | many bacterial appendages have filamentous structures, often composed of repeating monomers assembled in a head-to-tail manner. the mechanisms of such linkages vary. we report here a novel protein oligomerization motif identified in the fada adhesin from the gram-negative bacterium fusobacterium nucleatum. the 2.0 angstroms crystal structure of the secreted form of fada (mfada) reveals two antiparallel alpha-helices connected by an intervening 8-residue hairpin loop. leucine-leucine contacts pla ... | 2009 | 18996848 |
| uncultivated bacteria as etiologic agents of intra-amniotic inflammation leading to preterm birth. | intra-amniotic infection and inflammation are major causes of preterm birth (ptb). however, intra-amniotic inflammation is often detected in the absence of infection. this may partly be due to the culturing methods employed in hospital laboratories, which are unable to detect the uncultivated species. in this study, intra-amniotic microbial infections associated with ptb were examined by both culture and 16s rrna-based culture-independent methods and were corroborated by the presence of intra-am ... | 2009 | 18971361 |
| transmission of periodontopathic bacteria from natural teeth to implants. | purpose: prevention of peri-implantitis is essential for the success of implant rehabilitation. infection by periodontopathic bacteria is a major cause of peri-implantitis. the aim of the present study was to identify the source of peri-implant colonization by periodontopathic bacteria. materials and methods: twenty-one patients with implants were enrolled in the study. subgingival plaque samples from the adjacent, occluding, and contralateral natural teeth were collected prior to second-stage s ... | 2009 | 20002682 |
| effect of dietary omega-3 polyunsaturated fatty acids on experimental periodontitis in the mouse. | periodontitis is an infective disease caused predominantly by gram-negative anerobes. the host inflammatory response to these bacteria causes alveolar bone loss, which characterizes periodontitis. omega-3 polyunsaturated fatty acids have recognized anti-inflammatory effects; their oxygenated derivatives are key mediators in reducing inflammation. in this study we tested the hypothesis that dietary supplementation with tuna fish oil rich in the n-3 polyunsaturated fatty acid, docosahexaenoic acid ... | 2009 | 19210341 |
| does pregnancy have an impact on the subgingival microbiota? | we investigated clinical and subgingival microbiologic changes during pregnancy in 20 consecutive pregnant women > or =18 years not receiving dental care. | 2009 | 19228092 |
| purulent pericarditis in patient with esophageal cancer presenting with cardiac tamponade. | 2009 | 19272728 | |
| an in vitro evaluation of hydrolytic enzymes as dental plaque control agents. | the plaque-control potential of commercially available amylase, lipase and protease was evaluated by observing their effects on coaggregation and on bacterial viability within various plaque microcosms. a quantitative coaggregation assay indicated that protease significantly inhibited the extent of coaggregation of actinomyces naeslundii and streptococcus oralis (p <0.05) and of porphyromonas gingivalis and s. oralis. amylase significantly (p <0.05) increased the coaggregation of a. naeslundii v ... | 2009 | 19273645 |
| fusobacterium nucleatum atcc 10953 requires actinomyces naeslundii atcc 43146 for growth on saliva in a three-species community that includes streptococcus oralis 34. | formation of dental plaque is a developmental process involving initial and late colonizing species that form polymicrobial communities. fusobacteria are the most numerous gram-negative bacteria in dental plaque, but they become prevalent after the initial commensal colonizers, such as streptococci and actinomyces, have established communities. the unusual ability of these bacteria to coaggregate with commensals, as well as pathogenic late colonizers, has been proposed to facilitate colonization ... | 2009 | 19286780 |
| tlr2 sensing of f. nucleatum and s. sanguinis distinctly triggered gingival innate response. | gingival tissue faces constant exposure to micro-organisms. it functions as part of the host response, an anti-microbial barrier that recognizes and discriminates between commensal and pathogenic bacteria. this study aimed to evaluate and compare the effects of cell wall extracts from different periodontal bacteria, commensals streptococcus sanguinis and fusobacterium nucleatum and the pathogen porphyromonas gingivalis, on the innate immune response of gingival keratinocytes and the role of tlr2 ... | 2009 | 19299164 |
| characterization of the complex bacterial communities colonizing biliary stents reveals a host-dependent diversity. | this study provides a comprehensive survey of the spatial and temporal bacterial composition of biliary stent biofilms. the bacterial diversity, distribution and dynamics of 59 biliary and 4 pancreatic stent communities from 40 patients being treated at two different hospitals, which implant stents either simultaneously or consecutively, were characterized by single-strand conformation polymorphism (sscp) analysis. fifty-one phylotypes belonging to 5 bacterial phyla and 24 bacterial families wer ... | 2009 | 19360025 |
| bacterial culture and dna checkerboard for the detection of internal contamination in dental implants. | the aim of this in vitro study was to evaluate the bacterial leakage along the implant-abutment interface by the conventional bacterial culture and dna checkerboard hybridization method. | 2009 | 19374709 |
| are putative periodontal pathogens reliable diagnostic markers? | periodontitis is one of the most common chronic inflammatory diseases. a number of putative bacterial pathogens have been associated with the disease and are used as diagnostic markers. in the present study, we compared the prevalence of oral bacterial species in the subgingival biofilm of generalized aggressive periodontitis (gap) (n = 44) and chronic periodontitis (cp) (n = 46) patients with that of a periodontitis-resistant control group (pr) (n = 21). the control group consisted of subjects ... | 2009 | 19386852 |
| the oxyr homologue in tannerella forsythia regulates expression of oxidative stress responses and biofilm formation. | tannerella forsythia is an anaerobic periodontal pathogen that encounters constant oxidative stress in the human oral cavity due to exposure to air and reactive oxidative species from coexisting dental plaque bacteria as well as leukocytes. in this study, we sought to characterize a t. forsythia orf with close similarity to bacterial oxidative stress response sensor protein oxyr. to analyse the role of this oxyr homologue, a gene deletion mutant was constructed and characterized. aerotolerance, ... | 2009 | 19389765 |
| periodontal pathogen levels in adolescents before, during, and after fixed orthodontic appliance therapy. | this purpose of this study was to document and investigate changes in periodontal pathogen levels before, during, and after orthodontic treatment in adolescents. | 2009 | 19121507 |
| short-term clinical and microbiological evaluations of peri-implant diseases before and after mechanical anti-infective therapies. | the aim of this study was to evaluate the clinical and microbiological effects of mechanical anti-infective therapies for mucositis and peri-implantitis. | 2009 | 19126114 |
| the microbiota of acute apical abscesses. | as the breadth of bacterial diversity in the oral cavity has been deciphered by molecular studies, several newly identified species/phylotypes have emerged as potential pathogens. we hypothesized that many of these species/phylotypes could also be involved with the etiology of endodontic abscesses. abscess aspirates from 42 persons were analyzed for the presence of 81 species/phylotypes by means of a reverse-capture checkerboard hybridization assay. associations between the most frequently detec ... | 2009 | 19131319 |
| characterization of coaggregation of fusobacterium nucleatum pk1594 with six porphyromonas gingivalis strains. | coaggregation is a key mechanism in biofilm formation. the aim of this study was to characterize the coaggregation of fusobacterium nucleatum pk1594 with six porphyromonas gingivalis strains in terms of kinetics and sugars inhibition. this coaggregation was quantitatively characterized by using a kinetic coaggregation assay. sugar inhibition profiles were also quantitatively defined. four types of interactions among these coaggregation partners were found: (1) fast coaggregation that was substan ... | 2009 | 19084124 |
| enhanced attachment of porphyromonas gingivalis to human fibroblasts mediated by fusobacterium nucleatum. | fusobacterium nucleatum and porphyromonas gingivalis are often co-isolated from endodontic infection sites. the present study tested the hypothesis that adhesin-mediated reactions might contribute to this phenomenon. f. nucleaum pk1594 and p. gingivalis pk1924 were selectively labeled with fluorochromes and allowed to adhere to human fibroblasts, either each strain alone or sequentially. the number of bacteria of each type adhering to individual fibroblasts was determined. sugar inhibition profi ... | 2009 | 19084131 |
| synergistic pathogenicity of porphyromonas gingivalis and fusobacterium nucleatum in the mouse subcutaneous chamber model. | porphyromonas gingivalis and fusobacterium nucleatum are often coisolated from sites of infection, such as suppurative apical periodontitis. the synergistic pathogenicity of mixed infection of p. gingivalis hg 405 with f. nucleatum pk 1594 was studied in the mouse subcutaneous chamber model in groups of seven animals. the minimal dose for p. gingivalis hg 405 that was required to infect 100% of the chambers was reduced by 1,000-fold when animals were inoculated in the same chamber with 1 x 10(9) ... | 2009 | 19084132 |
| granulocyte chemotactic protein 2 (gcp-2/cxcl6) complements interleukin-8 in periodontal disease. | mucosal inflammatory responses are orchestrated largely by pro-inflammatory chemokines. the chemokine granulocyte chemotactic protein 2 (cxcl6) is involved in neutrophil recruitment and migration. previous studies have shown that granulocyte chemotactic protein 2 is up-regulated during mucosal inflammation (e.g. in inflammatory bowel disease), similarly to the functionally and structurally related chemokine interleukin-8. nevertheless, unlike interleukin-8, a role of granulocyte chemotactic prot ... | 2009 | 18842116 |
| oral bacteria modulate invasion and induction of apoptosis in hep-2 cells by pseudomonas aeruginosa. | pseudomonas aeruginosa is an important opportunistic bacterial pathogen, causing infections of the respiratory and other organ systems in susceptible hosts. p. aeruginosa infection is initiated by adhesion to and invasion of mucosal epithelial cells. the failure of host defenses to eliminate p. aeruginosa from mucosal surfaces results in p. aeruginosa proliferation, sometimes followed by overt infection and tissue destruction. there is growing evidence that associates poor oral health and respir ... | 2009 | 19041936 |
| the fusobacterium nucleatum outer membrane protein radd is an arginine-inhibitable adhesin required for inter-species adherence and the structured architecture of multispecies biofilm. | a defining characteristic of the suspected periodontal pathogen fusobacterium nucleatum is its ability to adhere to a plethora of oral bacteria. this distinguishing feature is suggested to play an important role in oral biofilm formation and pathogenesis, with fusobacteria proposed to serve as central 'bridging organisms' in the architecture of the oral biofilm bringing together species which would not interact otherwise. previous studies indicate that these bacterial interactions are mediated b ... | 2009 | 19007407 |
| factors affecting human supragingival biofilm composition. i. plaque mass. | little is known about the factors that affect the microbial composition of supragingival biofilms. this study was designed to examine the relationship between total dna probe counts of supragingival biofilm samples, clinical parameters and supragingival biofilm composition. | 2009 | 18973540 |
| in vitro bactericidal activity of recombinant human beta-defensin-3 against pathogenic bacterial strains in human tooth root canal. | human beta-defensin-3 (hbd3), an endogenous antimicrobial peptide, has strong broad-spectrum antimicrobial activity. this study aimed to obtain recombinant hbd3 (rhbd3) and to test the hypothesis that the antimicrobial characteristics of hbd3 may offer an advantage over conventional medicine in reducing intracanal bacteria. genetic engineering was used to obtain active rhbd3 and analysis revealed that it exhibited a broad spectrum of antibacterial activity at low micromolar concentrations agains ... | 2009 | 18775647 |
| photodynamic therapy as adjunct to non-surgical periodontal treatment in patients on periodontal maintenance: a randomized controlled clinical trial. | recent preclinical and clinical data have suggested the potential benefit of photodynamic therapy (pdt) in the treatment of periodontitis. however, currently, there are very limited data from controlled clinical trials evaluating the effect of pdt in the treatment of periodontitis. the aim of the present study was to evaluate the clinical and microbiological effects of the adjunctive use of pdt in non-surgical periodontal treatment in patients receiving supportive periodontal therapy. twenty-fou ... | 2009 | 18465191 |
| fusobacterium bacteremia: clinical significance and outcomes. | fusobacterium bacteremia is uncommon, accounting for approximately 0.9% of patients with bacteremia. the objectives of this study were to evaluate the incidence and clinical significance of blood cultures positive for fusobacterium spp., risk factors for mortality, and the impact of antimicrobial therapy on clinical outcomes. | 2009 | 19949758 |
| sonic extracts from a bacterium related to periapical disease activate gelatinase a and inactivate tissue inhibitor of metalloproteinases timp-1 and timp-2. | to examine the effects of sonicated bacterial extracts (sbes) from three related to periapical disease bacteria (porphyromonas gingivalis, p. endodontalis and f. nucleatum) on the activation of matrix metalloproteinase (mmp-2) and the inactivation of tissue inhibitors of metalloproteinase (timp-1 and timp-2). | 2009 | 19912382 |
| an unusual autopsy case of pyogenic liver abscess caused by periodontal bacteria. | pyogenic liver abscess (pla) formation is thought to originate from the transmission of infection via three major routes including the biliary tract, portal vein and hepatic artery. however, about 50% of pla cases are considered to be cryptogenic. here we report an unusual autopsy case of pla associated with periodontopathic bacterial infection. a 59-year-old female suddenly developed cardiopulmonary arrest and died. despite macroscopic and microscopic examinations, the infectious routes and sou ... | 2009 | 19762989 |
| kinetic characterization and quaternary structure of glutamate racemase from the periodontal anaerobe fusobacterium nucleatum. | cofactor-independent glutamate racemases (grs) that supply the d-glutamate required for biosynthesis of the peptidoglycan that encapsulates bacterial cells are attractive targets for the development of antibacterial drugs. recombinant gr from fusobacterium nucleatum (fngr), a gram-negative anaerobe involved in periodontal disease, was overproduced, purified, and characterized. unlike most other grs, fngr is a pseudosymmetric enzyme, catalyzing the racemization of glutamate enantiomers with simil ... | 2009 | 19772853 |
| differential ability of periodontopathic bacteria to modulate invasion of human gingival epithelial cells by porphyromonas gingivalis. | periodontitis is a polymicrobial infection caused by selected gram-negative bacteria including porphyromonas gingivalis. host cell invasion by p. gingivalis has been proposed as a possible mechanism of pathogenesis in periodontitis. the aim of the present study was to assess the influence of periodontopathogens on p. gingivalis invasion of gingival epithelial cells in polymicrobial infection. p. gingivalis was tested for its ability to invade a human gingival epithelial cell line ca9-22 in co-in ... | 2009 | 19818393 |
| construction of an ileal reservoir in patients with a previous straight endorectal ileal pull-through. | a decade has passed since martin and associates presented the first series of endorectal ileal pull-through (pt) procedures with straight ileoanal anastomosis for treatment of ulcerative colitis and polyposis. during the ensuing years, several medical centers have reported their results using the pt. although some children have experienced good results, the majority of adults and children have had severe problems associated with high stool frequency, urgency, and incontinence. between 1977 and 1 ... | 2009 | 2839124 |
| construction of an ileal reservoir in patients with a previous straight endorectal ileal pull-through. | a decade has passed since martin and associates presented the first series of endorectal ileal pull-through (pt) procedures with straight ileoanal anastomosis for treatment of ulcerative colitis and polyposis. during the ensuing years, several medical centers have reported their results using the pt. although some children have experienced good results, the majority of adults and children have had severe problems associated with high stool frequency, urgency, and incontinence. between 1977 and 1 ... | 2009 | 2839124 |
| hope for aids vaccines. | 2009 | 2781299 | |
| sleep apnea in alzheimer's disease. | mental deterioration accompanying sleep apnea has been noted frequently. because sleep apnea increases with age, such deficits raise the possibility that dementia in the elderly could be related to sleep apnea. in this study we investigated this possibility cross-sectionally by comparing respiration during sleep in 28 patients with alzheimer's disease (ad) and 25 nondemented controls. we hypothesized that higher levels of sleep apnea would be present in ad patients. our results indicated no sign ... | 2009 | 2812195 |
| sleep apnea in alzheimer's disease. | mental deterioration accompanying sleep apnea has been noted frequently. because sleep apnea increases with age, such deficits raise the possibility that dementia in the elderly could be related to sleep apnea. in this study we investigated this possibility cross-sectionally by comparing respiration during sleep in 28 patients with alzheimer's disease (ad) and 25 nondemented controls. we hypothesized that higher levels of sleep apnea would be present in ad patients. our results indicated no sign ... | 2009 | 2812195 |
| [studies on the constituents of trichosanthes root. ii. constituents of roots of trichosanthes cucumeroides maxim]. | from the fresh roots of trichosanthes cucumeroides maxim., three new triterpenoid glycosides with a bitter taste were obtained together with methyl palmitate, palmitic acid, alpha-spinasterol, stigmast-7-en-3 beta-ol, alpha-spinasterol 3-o-beta-d-glucopyranoside, stigmast-7-en-3 beta-ol 3-o-beta-d-glucopyranoside and vanillic acid. on the basis of the results of spectral and chemical investigations, these glycosides were characterized as 25-o-beta-d-glucopyranosyl-11-oxocucurbit-5-ene-3 beta,24( ... | 2009 | 2760812 |
| 31p-nmr study on intracellular energy transport in muscle. | 2009 | 2798486 | |
| 31p-nmr study on intracellular energy transport in muscle. | 2009 | 2798486 | |
| effects of early maturation on fetal growth. | while the association of young maternal age with low birthweight (lbw) is well known, the contribution of early menarche to this association has never been studied. we examined the effects of early menarche (less than or equal to 11 years) on lbw and its two major underlying causes: pre-term delivery and smallness-for-gestational-age (sga). results represent a narrow chronological age range, 17-18 years, of a larger geographically based cohort of 2789 pregnant adolescents. adjusted odds ratios ( ... | 2009 | 2782851 |
| allocation and the physician: the impacts of aging and aids. | 2009 | 2709175 | |
| [plastic surgery in otorhinolaryngology: reconstruction flaps in oncologic surgery]. | 2009 | 2701493 | |
| transcardiac passage of thrombus--ultrasonographic visualization. | a patient is described in whom a right atrial thrombus was seen, by two-dimensional echocardiography, in the act of embolizing into the pulmonary circulation. | 2009 | 2702500 |
| [essential arterial hypertension in patients with non-insulin-dependent diabetes mellitus during and after balneotherapy followed-up for 6 years]. | the statistical correlations between body weight, glycemia, total lipids, cholesterol in 200 patients with essential hypertension, especially borderline essential hypertension, followed up for 6 years indicate that the complex environmental factors in slănic-moldova health resort associated with balneotherapy may induce a return to normal values of the above mentioned parameters. good results were also obtained in the patients with essential hypertension and non-insulin dependent diabetes mellit ... | 2009 | 2636767 |
| serum levels of bilirubin and biliverdin in the sea lamprey, petromyzon marinus l., before and after their biliary atresia. | 1. the sera of ammocoetes, juvenile adults, and upstream migrants of the sea lamprey, petromyzon marinus l., were analyzed for the presence of the bile pigments, biliverdin and bilirubin. 2. bile pigment was not detected in the sera of ammocoetes. 3. after biliary atresia (degeneration of bile ducts at metamorphosis), bilirubin and biliverdin were detected in the sera of both juvenile adults and upstream migrants. 4. these data suggest that lampreys have some bile stasis following biliary atresi ... | 2010 | 2887360 |
| effects of momorcharins on ovarian response to gonadotropin-induced superovulation in mice. | alpha- and beta-momorcharins, which are abortifacient proteins isolated from momordica charantia seeds, were tested for a possible effect on ovulation and plasma levels of ovarian steroids in mice induced to superovulate by pmsg and hcg. the plant proteins did not affect follicular recruitment and maturation as evidenced by ovarian histology and serum 17 beta-estradiol level. both proteins diminished the number of oocytes ovulated when given on the day prior to or on the day of pmsg treatment, b ... | 2010 | 2898450 |
| excitatory amino acids and the blood-brain barrier (bbb). | 2010 | 2878562 |