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plasmid content of some oral microorganisms isolated from subgingival plaque.eighty-five strains of bacterial species selected from the predominant cultivable dental plaque flora of patients with different periodontal pathologies were examined for their plasmid content. microorganisms studied included: actinomyces viscosus, a. odontolyticus, bacteroides asaccharolyticus (b. gingivalis), b. melaninogenicus subspecies intermedius, and subspecies melaninogenicus, capnocytophaga ochracea (b. ochraceus), and fusobacterium nucleatum. three b. melaninogenicus isolates showed pl ...19826949951
histological and histochemical study of the influence of lipopolysaccharide extracted from fusobacterium nucleatum on the periapical tissues in the monkey macaca fascicularis. 19816947763
bacteriologic evaluation of the efficacy of mechanical root canal instrumentation in endodontic therapy.the presence of bacteria in 17 single-rooted teeth, with periapical lesions, was studied throughout a whole period of treatment. the root canals were irrigated with physiologic saline solution during instrumentation. no antibacterial solutions or dressings were used. bacteria were found in all initial specimens from the teeth (median number of bacterial cells 4 x 10(5), range 10(2) - 10(7)) and the number of strains in the specimens ranged from 1 to 10.88% of the strains were anaerobic. the most ...19816947391
the predominant cultivable dental plaque flora of beagle dogs with periodontitis.the predominant cultivable dental plaque flora was studied in 10 adult female beagle dogs with advanced periodontitis. supragingival and subgingival plaque from a maxillary third premolar (p3) was removed and cultured anaerobically on various growth media and all colonies were subcultured and partially characterized. histopathological specimens of the plaque sampling sites showed significant loss of connective tissue attachment. spirochetes were found in all samples. anaerobic gram-negative orga ...19816941977
immune response in rats against lipopolysaccharides of fusobacterium nucleatum and bacteroides oralis administered in the root canal.lipopolysaccharides (lps) prepared from one strain of fusobacterium nucleatum and one strain of bacteroides oralis were examined for immunological responses in rats. the lps were applied to the pulp chamber of the two mandibular incisors. using the plaque forming cell (pfc) method both antigens showed a rapid igm response in the spleen, and a slower one in the submandibular lymph nodes. in comparison with the igm response, the igg response was somewhat slower and weaker for lps of bacteroides, w ...19806929559
[studies of mixed anaerobic infections involving bacteroides gingivalis].the infectiousness of several combinations of bacteria containing bacteroides gingivalis and other bacteria associated with periodontal diseases was evaluated by subcutaneous injection to guinea pigs. among the seven mixtures studied, only one permitted the development of an infection easily transmissible to a second guinea pig; this bacterial mixture was composed of b. gingivalis, fusobacterium nucleatum, eubacterium saburreum, and capnocytophaga ochracea (formerly bacteroides ochraceus). owing ...19836883221
penicillin failure in the treatment of bacteroides fragilis lung abscess. experimental study in rabbits.carbenicillin, chloramphenicol, doxycycline, and clindamycin were compared with penicillin for the treatment of lung abscess in an animal model produced by transtracheal inoculation of a mixture of anaerobes: bacteroides fragilis, peptococcus morbillorum, eubacterium lentum and fusobacterium nucleatum. both chloramphenicol and doxycycline eliminated the bacteria but failed to close the abscess cavity. carbenicillin, although it eradicated b. fragilis, failed to close the abscess cavity in 3 of 6 ...19836872619
treatment of anaerobic infections in children with metronidazole.the tolerance and efficacy of metronidazole were studied in 15 pediatric patients who had anaerobic infection. 5 had soft tissue abscess, 4 had aspiration pneumonia, 3 had intracranial abscess and 3 had chronic sinusitis. 45 bacterial isolates were recovered (3 isolates per patient). 40 were anaerobes and included 17 bacteroides sp. (8 sp.), 16 anaerobic cocci and 6 fusobacterium nucleatum. metronidazole was given intravenously at the dose of 30 mg/kd/day or orally in the dose of 40-50 mg/kg/day ...19836861605
fusobacterium nucleatum pericarditis.a pericardial effusion was diagnosed by echocardiography in a 49 year old man who suffered acute cough, orthopnea, and chest pain. because of a positive tuberculin skin test, mycobacteria were initially suspected as the cause of the pericarditis. the patient was therefore treated with antituberculosis drugs. the pericardial effusion failed to resolve, however, and pericardiectomy was performed. culture of the pericardial fluid yielded pure fusobacterium nucleatum growth. the patient responded to ...19836833485
production, purification, and properties of a bacteriocin from staphylococcus aureus isolated from saliva.staphylococci from samples of human saliva were isolated on staphylococcal-selective agar plates. these strains were tested for the inhibition of the growth of staphylococcus aureus fda209p. the frequency of inhibitory strains among all of the staphylococcal isolates was 5.2%. strain iys2, which formed the biggest inhibitory zone against the growth of the indicator strain, was used as the producer of bacteriocin. iys2 was identified to be s. aureus, based on its biological properties. the bacter ...19836832811
the elisa system for measuring antibody reactive to fusobacterium nucleatum in the sera of patients with chronic periodontitis.humoral igg, iga and igm responses to three typed oral strains of f. nucleatum were examined in patients with chronic periodontitis and in individuals with clinically healthy gingiva. attempts were made to isolate f. nucleatum from either the pathologic gingival crevices or healthy sulci in this study. higher levels of igg and iga reactive to all three strains were observed in the chronic periodontitis patients; however, there were no differences between the igm levels in the diseased and health ...19826818334
pathway of lysine degradation in fusobacterium nucleatum.lysine was fermented by fusobacterium nucleatum atcc 25586 with the formation of about 1 mol each of acetate and butyrate. by the use of [1-14c]lysine or [6-14c]lysine, acetate and butyrate were shown to be derived from both ends of lysine, with acetate being formed preferentially from carbon atoms 1 and 2 and butyrate being formed preferentially from carbon atoms 3 to 6. this indicates that the lysine carbon chain is cleaved between both carbon atoms 2 and 3 and carbon atoms 4 and 5, with the f ...19826811551
anaerobic bacteria in dentoalveolar infections.the bacteriology of 57 dentoalveolar infections was studied using optimal techniques to collect, transport and process specimens. there was an average of 4 bacterial species per specimen, and only 1/3 of the specimens held aerobes. among the aerobic bacteria, streptococci dominated and among the anaerobes the gram-negative rods, bacteroides ruminicola and fusobacterium nucleatum, were most frequently isolated followed by gram-positive cocci, in particular streptococcus intermedius. all aerobic i ...19816807917
attachment of cell fragments of fusobacterium nucleatum to oral epithelial cells, gingival fibroblasts and white blood cells.the characteristic haemagglutination (ha) caused by fusobacterium nucleatum strains was used for measuring their attachment to oral epithelial, gingival fibroblast and white blood cells. whole cells and sonicated preparations of oral f. nucleatum strains vpi no. 4355, 10197 and atcc no. 10953 haemagglutinated human and sheep red blood cells. sonicated preparations of the organisms were tested for ha activity before and after absorption with human cells. buccal epithelial, gingival fibroblast and ...19826751304
[amniotic infection with fusobacterium nucleatum]. 19846742716
immunoglobulin g response to subgingival gram-negative bacteria in human subjects.serum and gingival crevicular fluid from normal healthy adults and patients with periodontitis were screened for immunoglobulin g antibodies to antigens from bacteroides gingivalis 381, bacteroides intermedius 24, bacteroides loescheii atcc 15930, fusobacterium nucleatum atcc 25586, eikenella corrodens 1073, actinobacillus actinomycetemcomitans atcc 29522, and capnocytophaga sp. strain m-12. immunoglobulin g antibody titers to the antigens were measured by an enzyme-linked immunosorbent assay. t ...19846735473
osteomyelitis in dogs and cats caused by anaerobic bacteria.localised osteomyelitis was diagnosed in 2 dogs and 2 cats. the disease was caused by fight wounds in 3 cases. radiographic examination demonstrated a circumscribed zone of cortical bone lysis, sequestra and periosteal new bone. each case was treated surgically by sequestrectomy and debridement. infection was due mainly to anaerobic bacteria. the pathogenic bacteria isolated from the lesions of dogs were actinomyces viscosus, fusobacterium nucleatum and bacteroides spp, and from the lesions in c ...19846732670
suppression of human peripheral blood lymphocytes by fusobacterium nucleatum.fusobacterium nucleatum has been implicated in the pathogenesis of several diseases, including urinary tract infections, bacteremia, pericarditis, otitis media, and disorders of the oral cavity such as pulpal infections, alveolar bone abscesses, and periodontal disease. in this study, we examined sonic extracts of f. nucleatum strain fdc 364 for its ability to alter human lymphocyte function. we found that the soluble cytoplasmic fraction (cf) of the sonic extract was able to cause a dose-depend ...19846715883
in vitro activity of u-57930e against anaerobic bacteria and its comparison with clindamycin, ampicillin, carbenicillin and tetracycline.the in vitro activity of u-57930e, a pipecolic acid amide of clindamycin, was compared with those of clindamycin, ampicillin, carbenicillin and tetracycline against 321 anaerobic clinical isolates. the mic (micrograms/ml) of u-57930e that inhibited 95% bacteroides fragilis, peptococcus prevotii, b. melaninogenicus and p. asaccharolyticus was 0.0625; 0.03125 for peptostreptococcus anaerobius, b. vulgatus, propionibacterium and peptococcus species. clindamycin, on the other hand, gave mic values o ...19836678915
death of an african elephant from probable toxemia attributed to chronic pulpitis.a 31-year-old captive male african elephant (loxodonta africana) of 5,000-kg body weight died suddenly in ventral recumbency. lesions seen at necropsy were bilateral purulent pulpitis and periodontitis of both tusks, serous atrophy of coronary groove fat, grammocephalus cholangitis, myocardial and skeletal lipofuscinosis, and scattered segmental necrosis in the pectoral muscles. nonhemolytic streptococci, corynebacterium sp, peptostreptococcus anaerobius, fusobacterium nucleatum, and bacteroides ...19836643242
bacteriology of dental abscesses of endodontic origin.aspirates have been cultured from 10 dental abscesses of endodontic origin, all of which had penetrated beyond the bony alveolus to produce fluctuant swelling. sampling was by syringe aspiration. strict anaerobic techniques, including the use of an anaerobic chamber, were used for serial dilution and plating. randomly selected colonies (100) from each culture were purified, characterized, and identified. seventy percent of the bacterial isolates were either strict anaerobes or microaerophilic. o ...19836630460
nonspecific induction of immunoglobulin m antibodies to periodontal disease-associated microorganisms after polyclonal human b-lymphocyte activation by fusobacterium nucleatum.the production of antibodies to oral bacteria was determined in lymphocyte cultures stimulated with sonicated fusobacterium nucleatum, a potent inducer of polyclonal b-cell activation. after 9 days the cultures were examined by a microenzyme-linked immunosorbent assay for immunoglobulin m (igm) antibodies to f. nucleatum, bacteroides gingivalis, actinomyces viscosus, and streptococcus sanguis. antibodies to these four bacteria were detected in cultures stimulated with polyclonal b-cell activatio ...19836604024
polyclonal activation of human peripheral blood b lymphocytes by fusobacterium nucleatum.the present study examined in vitro polyclonal human b-lymphocyte (b-cell) activation (pba) by fusobacterium nucleatum. pokeweed mitogen, a well-studied pba activator, was included in some experiments for comparison. pba was determined by the total immunoglobulin a, g, and m concentrations in the culture supernatants as measured by micro-enzyme-linked immunosorbent assay. f. nucleatum, at concentrations between 1 and 10 micrograms/ml, stimulated optimal pba in monocyte-depleted cultures, whereas ...19836602093
the effect of storage in liquid nitrogen on the recovery of human dental plaque bacteria.centrifuged deposits of various individual bacteria from type-culture collections and dental plaque samples were immersed in liquid nitrogen for periods of up to 2 years. all the organisms were recovered after storage in liquid nitrogen but fusobacterium nucleatum (atcc 10953) and campylobacter fetus (nctc 10354) consistently showed a reduction in the number of colony-forming units after freezing. the main effect on bacterial proportions in plaque samples was a reduction in aerobic gram-negative ...19846596040
immunologic profile of juvenile periodontitis. i. lymphocyte blastogenesis and the autologous mixed lymphocyte response.studies of blastogenesis of lymphocytes in culture from juvenile periodontitis (jp) patients have been inconclusive. experiments demonstrating differences in lymphocyte blastogenesis to preparations of putative periodontopathogens in jp and phytohaemagglutinin (pha) were performed. variables in the blastogenesis assay system recently reported were controlled which included using a range of cell and activator concentrations, incubation times of 3, 5 and 7 days, conical-bottomed microtest wells an ...19846592318
antibacterial properties of human lysozyme toward fusobacterium nucleatum fev1.human lysozyme in physiologic concentrations (17-50 micrograms/ml) had apparently no effects on growth rate and viability of exponentially growing fusobacterium nucleatum fev1 cells, but cells in the stationary phase were affected. when grown in the presence of active lysozyme about 70% of the cells in late exponential phase (24-h culture) were able to form colonies, compared to about 100% in the control culture. about 24 h later the colony forming abilities were about 5% and 20%, respectively. ...19846585918
[susceptibility of potential periodontopathic bacteria to metronidazole, spiramycin and their combination].a total of 65 bacterial strains originating mostly from subgingival plaque were tested for their susceptibilities to metronidazole, spiramycin, and their combination, ornidazole, erythromycin and tetracycline by means of an agar dilution technique. all agents were active against all anaerobic gram-negative rods. bacteroides gingivalis and fusobacterium nucleatum showed marked susceptibility to metronidazole (mic less than or equal to 0.06 microgram/ml) whereas 4-64 micrograms/ml were required to ...19846584423
immunologic studies of endodontic disease: measurement by the elisa technique of antibody reactive with fusobacterium nucleatum in the serum of endodontic patients. 19836584421
cellular fatty acid and soluble protein profiles of oral fusobacteria.we compared the cellular fatty acid and protein content of 43 strains of oral fusobacteria isolated from patients with chronic gingivitis, acute necrotizing ulcerative gingivitis, and juvenile and adult periodontitis, as well as from the stump-tailed macaque, to that of eight reference strains of oral and non-oral fusobacterium species. a gas-liquid chromatographic examination of trimethylsilyl derivatives of the fatty acid methyl esters revealed n14:0, 3-oh-14:0, n16:0, 16:1, 3-oh-16:0, n18:0, ...19836581193
[proportion and frequency of 3 kinds of anaerobic bacteria in relation to the gingival index].the proportion and frequency of three groups of particular bacteria (bacteroides, fusobacterium and spirochetes) were studied in relation to the gingival index on the sites from which they were sampled. seventy eight samples collected from 40 individuals were studied together with measurements of the gingival index and the pocket or sulcus depth. the samples were dispersed by ultrasonic treatment, diluted and cultured on a non-selective medium. the identification of the species was done by bioch ...19836581165
haemolysis of human erythrocytes by the fusobacterium nucleatum associated with periodontal disease.fusobacterium nucleatum and bacteroides gingivalis are associated with oral disease. they both attach to haemagglutinate and human erythrocytes. experiments were performed to determine whether haemolysis would occur following attachment of strains of f. nucleatum and bacteroides species including b. gingivalis. the f. nucleatum strains consistently displayed both haemagglutination and haemolytic activity. the b. gingivalis strains and other bacteroides species displayed haemagglutination but no ...19836579906
anaerobic pulmonary infections.the main cause of anaerobic pulmonary infections is aspiration of saliva, upper airway secretions of gastric content. predisposing conditions include prominent dental disease, chronic upper respiratory tract infections and reduced consciousness. fusobacterium nucleatum, bacteroides melaninogenicus and anaerobic gram-positive cocci are the most frequently encountered organisms. the clinical presentations are lung abscess, lung gangrene and empyema, which all tend to take a slow and indolent cours ...19836578589
effect of factors other than pathologic status on responsiveness of peripheral blood mononuclear cells from patients with chronic periodontitis.studies were designed to assess factors other than pathologic status of the cell donor which affect the blastogenic responsiveness in vitro of peripheral blood mononuclear cells (pbms) from normal donors and patients with periodontitis. cultures were established and activated using phytohemagglutinin-p (pha) or homogenates of actinomyces viscosus (avis), a gram-positive plaque microorganism, and fusobacterium nucleatum (fuso), a gram-negative plaque microorganism. activation was assessed by meas ...19836577178
relationships among the oral fusobacteria assessed by dna-dna hybridization.dna was purified from 16 strains of fusobacterium nucleatum and from five strains representing other fusobacterium species. the relationships among fusobacteria were examined by dna-dna hybridization and by determining the guanine plus cytosine content of the dna. f. nucleatum was found to comprise a heterogenous group of organisms related to fusobacterium periodonticum and fusobacterium simiae, but unrelated to any of the other species of fusobacterium tested.19836574153
antitumor activity of sediment fractions from fusobacterium nucleatum culture supernatant.the present study was carried out to examine antitumor activity of extracts from fusobacterium nucleatum culture supernatant. the extracts were prepared as sediment fractions by ethanol precipitation, isoelectric point precipitation and proteolytic enzyme-treatment. an ethanol fraction obtained by addition of 60% ethanol to the culture supernatant showed effective antitumor activity to ascites and solid type tumor of ehrlich carcinoma and also to solid type tumor of sarcoma 180 in icr mice. a se ...19846513099
comparative efficacy of four antibiotics in anaerobic pulmonary infection. an experimental model in rabbits.the efficacy of cefoxitin, mezlocillin, latamoxef and metronidazole in anaerobic lung infection was studied using a rabbit model. a mixture of bacteroides fragilis, peptococcus morbillorum, eubacterium lentum and fusobacterium nucleatum was inoculated transtracheally to produce infection within the lung. mezlocillin was most effective, achieving bacteriologic cure in 5 out of 8 animals. with cefoxitin therapy, 4 out of 8 became bacteriologically sterile. severe diarrhea with elevated titers of c ...19846488936
bacteriology of experimental gingivitis in children.children are more resistant to gingivitis than are adults. to determine possible differences in their periodontal floras, an experimental gingivitis study, identical in design to one reported earlier with young adults, was conducted with four 4- to 6-year-old children. the incidence of sites that developed gingival index scores of 2 in children was less than one-third of the incidence observed in adults. the composition of the flora of each child was statistically significantly different from th ...19846480100
nature and location of amide-bound (r)-3-acyloxyacyl groups in lipid a of lipopolysaccharides from various gram-negative bacteria.it has previously been demonstrated [eur. j. biochem. 124, 191-198 (1982) and 137, 15-22 (1983)] that the lipid a component of salmonella and proteus lipopolysaccharides contains amide-linked (r)-3-acyloxyacyl residues. in the present study lipid a of other gram-negative bacteria was analysed for the presence of amide-bound 3-acyloxyacyl residues. it was found that such residues are constituents of all lipid a tested (agrobacterium tumefaciens, chromobacterium violaceum, pseudomonas aeruginosa, ...19846437812
antitumor activity in the culture supernatant fluid of fusobacterium nucleatum strain ko-31.antitumor activity of fusobacterium nucleatum strain ko-31, which had been isolated from the oral cavity, was investigated in ehrlich carcinoma-bearing mice. the strain ko-31 was cultured in tf medium for 48 hr. one-half ml of the culture supernatant fluid was injected intraperitoneally during a 7-day period to mice with ehrlich ascites carcinoma. the survival time of the treated mice prolonged remarkably. a significant reduction in size of the solid ehrlich tumor was also achieved with the supe ...19836433084
isolation, partial purification and preliminary characterization of a bacteriocin from streptococcus mutans rm-10.an extracellular bactericidal substance was isolated from the supernatant of streptococcus mutans rm-10 culture fluid and partially purified with 60% ammonium sulfate precipitation, differential centrifugation, and gel filtration on sephadex g-200. there was a good correlation of the sensitivity profiles of indicator strains whether assayed on solid medium or with purified material from cell-free culture fluid, indicating that the same inhibitory substance is produced on solid medium and in brot ...19836412623
comparison of serological reactions of typed fusobacterium nucleatum strains with those of isolates from humans, canines, and a macaca mulatta monkey.in the present study, we compared typed f. nucleatum strains with isolates from various human periodontal diseases, canines, and a macaca mulatta monkey. all isolates displayed biochemical reactions similar to those of the typed strains in the api 20a system (analytab products, plainville, n.y.). the human and monkey isolates displayed both type i and type ii colonial morphologies on crystal violet erythromycin agar, whereas the canine isolates displayed only type i. antigen preparations of the ...19836406540
clinical, microbiological and immunological features associated with the treatment of active periodontosis lesions.clinical, microbiological and immunological factors were examined using data from a subject with periodontosis. the subject was monitored at bimonthly intervals for 26 months at 6 sites per tooth for redness, plaque, suppuration, bleeding on probing, pocket depth, and attachment level. using attachment level measurements and the tolerance method of analysis, sites with active disease and control (inactive) sites of equal pocket depth were selected. subgingival plaque samples were taken from thes ...19846386896
recovery of anaerobic bacteria from vented blood-culture bottles.from january 1979, to july 1981, blood from each patient suspected of having bacteremia was collected in two bottles of commercially prepared tryptic soy broth; one bottle was vented for 24 hr to the atmosphere. bottles were incubated at 37 degrees c for a maximum of seven days and were examined daily for signs of growth. blind subcultures onto chocolate-agar plates were performed 18-24 hr after collection and again at 48 hr. for 63,106 bottles inoculated, a total of 4,788 strains were isolated, ...19846372038
role of anaerobic bacteria in bite-wound infections.the etiologic agents usually involved in wound infections due to human or animal bites are the aerobic skin flora of the victim, e.g., staphylococcus aureus, and/or the aerobic oral flora of the biter, e.g., pasteurella multocida. while anaerobic bacteria are predominant in the normal oral flora of humans and animals, their importance in the pathogenesis of bite-wound infections has not been stressed. most investigators in this field have either not cultured these wounds for anaerobic bacteria o ...19846372026
isolation of a major cell envelope protein from fusobacterium nucleatum.a major, heat-modifiable cell envelope protein was identified in fusobacterium nucleatum fdc 364 by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. this protein, designated hm-1, had apparent molecular weights of 38,500 and 50,000 when heated in sodium dodecyl sulfate at 50 and 100 degrees c, respectively. whole cells were labeled with 125i, and the results suggested that the hm-1 protein may be exposed on the bacterial surface. the hm-1 protein was isolated in association with the pe ...19846370865
monocyte suppression of fusobacterium nucleatum-induced human polyclonal b-lymphocyte activation.previous studies reported that fusobacterium nucleatum induced polyclonal b-lymphocyte activation (pba) as determined by immunoglobulin m production in cultures of human peripheral blood mononuclear cells. however, the pba response was greatly enhanced when the cells were depleted of esterase-positive, adherent cells (i.e., monocytes). the purpose of this study was to confirm and further examine the suppression of f. nucleatum-induced pba (f. nucleatum-pba) by blood monocytes. for comparison, pb ...19846334029
[antibiotic treatment of human actinomykoses (author's transl)].in the complex aetiology of human actinomykoses, various actinomyces species, especially a. israelii, play the pathogenetically leading role in the mixed flora so typical for these diseases. a number of other microaerophilic and anaerobic bacteria are also part of such mixed flora. since these "concomitant" bacteria are themselves potentially pathogenic, it is important to have data on antibiotic sensitivity for the entire spectrum of microorganisms, to achieve effective and economic chemotherap ...19826286266
capillary agar diffusion assay for measuring metronidazole in human gingival crevice fluid.an agar diffusion assay in capillaries, with fusobacterium nucleatum m2 as the indicator strain, has been developed to measure metronidazole concentrations in gingival crevice fluid. the assay allows the measurement of 1.9 micrograms of metronidazole per ml in sample amounts of 0.6 microliters.19826285816
filament formation of fusobacterium nucleatum cells induced by mecillinam.subinhibitory concentrations of mecillinam transformed fusobacterium nucleatum cells into a marked filament form, quite different from a spherical form demonstrated in escherichia coli.19816264847
induction of epstein-barr virus antigens in human lymphoblastoid p3hr-1 cells with culture fluid of fusobacterium nucleatum.epstein-barr virus-associated early antigen and viral capsid antigen were efficiently induced in human lymphoblastoid p3hr-1 cells with culture fluid of fusobacterium nucleatum, a member of the indigenous microbial flora of the human host. this finding may suggest a new approach to assess the possible role of the "cofactor(s)" in the etiology of epstein-barr virus-related diseases.19806258779
interaction of ia antigen-bearing polymorphonuclear leukocytes and murine splenocytes.polymorphonuclear leukocytes (pmn) were induced in the peritoneum of a balb/c mouse by ip injection of fusobacterium nucleatum (fn) (greater than 95% pmn). a subpopulation of pmn harvested bore ia surface antigens and stimulated a mixed lymphocyte reaction (mlr) when cultured with c57b1/6j splenocytes. the reaction was blocked by a short prior incubation of pmn with anti-ia antibody or pmn cell depletion by the same antibody plus complement. the ia antigen-bearing pmn were capable of antigenic m ...19836220969
neutrophil chemiluminescence in response to fusobacterium nucleatum. 19826219208
o-antigenic corss-reactivity in fusobacterium nucleatum: chemotype v lipopolysaccharides.nucleatum lipopolysaccharides (lps) of chemotype v were examined for cross-reactivity by indirect haemagglutination in non-absorbed and absorbed antisera. at least three o-antigenic specificities were detected in lps of five strains. there was a slight cross-reactivity between the lps of chemotype v and those of chemotype ii.19836191518
complement-dependent histamine release from rat peritoneal mast cells, induced by lipopolysaccharides from bacteroides oralis, fusobacterium nucleatum and veillonella parvula.the capacity of phenol/water extracted lipopolysaccharides (lps) from bacteroides, fusobacterium and veillonella to induce histamine release from rat peritoneal mast cells has been evaluated by means of a bioassay using atropinized guinea pig ileum and a fluorescence assay. histamine release was found to be completely complement dependent. it was also found that lps of veillonella have the greatest capacity to induce histamine release and bacteroides have the weakest.19816168752
corncob formation between fusobacterium nucleatum and streptococcus sanguis.corncob formation in dental plaque was believed to be limited to strains of bacterionema matruchotii and streptococcus sanguis. we observed recently that strains of fusobacterium nucleatum also interacted with s. sanguis to form corncobs. since the fusobacteria are among the first anaerobic filaments to colonize subgingival plaque, these interactions could serve as a connecting link between the transformation of supra- to subgingival plaque. to further characterize these interactions, quantitati ...19836131871
lysozyme digestion and chemical characterization of the peptidoglycan of fusobacterium nucleatum fev 1.the amino acids in the peptidoglycan of fusobacterium nucleatum fev 1 are d-glutamic acid, meso-lanthionine, and d- (42%) and l-alanine (58%). about 70% of the lanthionine residues were not susceptible to dinitrophenylation, evidently because they are involved in cross-linkages. consequently, lysozyme digestion of the peptidoglycan yielded 20 to 25% uncross-linked disaccharide tri- and tetrapeptides. a chemical analysis of isolated glycopeptides indicated that the structure of the building block ...19816114929
neutrophil chemotaxis induced by anaerobic bacteria isolated from necrotic dental pulps.anaerobic bacteria belonging to the species bacteroides melaninogenicus, bacteroides asaccharolyticus, fusobacterium nucleatum, peptostreptococcus anaerobius and eubacterium alactolyticum, isolated from necrotic dental pulps, were tested for their capacity to induce neutrophil leukocyte chemotaxis. generation of chemotactic factors in serum by whole bacterial cells and chemotaxis induced by bacterial extracts were studied in vitro by the boyden technique. subcutaneously implanted wound chambers ...19806103573
effect of bacterial contamination on cecal size and cecal contents of gnotobiotic rodents.in the present investigation the effect of various bacterial contaminations of gnotobiotic mice and rats on cecal size is presented. of the species tested, bacteroides oralis and fusobacterium nucleatum did not establish in germ-free mice. streptococcus mutans, clostridium difficile, a neisseria strain and two recent cecal isolates established, but failed to exert an effect upon the cecum of mice. a group k streptococcus and b. fragilis increased the cecal size apparently by increasing the level ...19695808078
[putrid purulent pleurisy with the presence of fusiformis nucleatus (knorr)]. 19695407170
amino acid fermentation by fusobacterium nucleatum. 19685238887
chemically induced dominant-lethal mutations and cell killing mouse oocytes in the advanced stages of follicular development. 19715111494
investigations on the reaction of azide with sperm whale ferrimyoglobin. 20165102440
chronic synovitis as a manifestation of calcium crystal deposition disease. 20165100635
[temple bone fracture, early diagnosis and surgical reconstruction of hearing]. 20165099388
[environment of the aged]. 20165098167
proteus infections in a general hospital. ii. some clinical and epidemiological characteristis. with an analysis of 71 cases of proteus bacteremia. 19715094068
thyroxine metabolism by pineal slices. 19715093955
[study of the action of citiolone on hepatocellular cytolysis in decompensating cirrhosis and in active chronic hepatitis]. 20165089130
[evolutive prospects of sonoinversion]. 20165088646
flow and composition of lymph collected from the skeletal muscle of the rabbit hind limb. 19725085348
direct measurements of the partial oxygen tension in different cortical and subcortical structures of the brain and in gliomas during stereotactic operation. 20165084385
cognitive styles in adolescents previously diagnosed as hyperactive. 20095081175
[isoagglutinin level in human saliva]. 19725076480
[therapeutic value of glutamic acid and procaine in the evolution of some metabolic changes in alloxan diabetes]. 19725075444
population screening for coronary risk factors. 20165075313
fractures of the cervical spine with minimal or no symptoms. 20165069413
[synthesis of high-molecular rna in cell cultures from higher plants]. 20165069318
rna synthesis during mammalian myogenesis in culture. 20165066247
president's message. 20165062586
in vitro evaluation of actinobolin as an antibiotic for the treatment of periodontal disease.actinobolin was evaluated in vitro by a paper disc-agar diffusion method for inhibitory activity against mixed microbial cultures obtained from patients with periodontal disease and against pure bacterial cultures tentatively identified as strains of bacteroides melaninogenicus, fusobacterium fusiforme, leptotrichia buccalis, and veillonella parvula. every culture tested was inhibited to some degree by actinobolin. these observations suggest that actinobolin may be effective in the treatment of ...19725059624
effects of phenobarbital and ethionine on hepatic and pancreatic functions of protein deprived rats. 19725059371
amenorrhoea after the pill. 20165058752
oliguric acute renal failure in malignant hypertension. 20165058504
radiographic applications of signal detection theory. 20155057304
radiographic applications of signal detection theory. 20155057304
[comparative studies on the effect of liquid administration on prolonged performance under heat conditions]. 20165056776
recent investigations on the prosthetic group of beef plasma amine oxidase. 19725054201
lightness, embeddedness, and contrast. 20075054071
[tetanus: active or passive vaccination after injury?]. 20165052940
a super-coil model for nucleohistone. 20165050359
[eeg and microelectrode study of a cortical focus of epileptic activity]. 19725048176
anthraquinone, a new chemical oxidation product of amitriptyline. 19725046134
cryopreservation of developing teeth. 20165045627
[carbohydrate metabolism in gonadal dysgenesis syndrome]. 20165043548
[neuroradiologic diagnosis of otogenic and rhinogenic cerebral complications]. 20165043350
[absence of an effect by chlorophos and its analogs on catalase and peroxidase of ascaridia galii]. 20155042569
an intrarenal foreign body. 20165041547
[erythema nodosum as 1 manifestation of the clinical course of pseudotuberculosis]. 20165039708
[functional state of the liver and bile ducts in chronic biliary tract diseases]. 20165039407
correlation of endometrial biopsy and plasma progesterone in infertile women. 20165039235
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