Publications

the challenge of malaria vaccine: trials and tribulations.		1987	2880172
stimulant-like effects of magnesium on aggression in mice.	the effects of magnesium excesses resulting from daily injections of magnesium chloride (mgcl2) were examined on offensive behavior in a resident-intruder situation. male mice tested 5 min post-injection of 15 mg/kg or 30 mg/kg exhibited a significantly greater number of attacks and threats than saline controls; while in mice injected with 125 mg/kg threat and attack behaviors were decreased. no tolerance developed to this decrease which persisted throughout the 15 day injection period. toleranc ...	2010	2880351
polyarteritis nodosa and familial mediterranean fever.	a 22-year-old familial mediterranean fever (fmf) patient was hospitalized for continuous fever, myalgia, hypertension, vertigo and a petechial rash. laboratory findings revealed hyperglobulinaemia, thrombocytosis and a leukaemoid reaction. while on steroid therapy the patient sustained a haemorrhage into a renal aneurysm which responded to gel foam embolization. after 12 months of follow-up his condition remained stable under treatment with cyclophosphamide, prednisone and antihypertensive medic ...	2009	2881591
polyarteritis nodosa and familial mediterranean fever.	a 22-year-old familial mediterranean fever (fmf) patient was hospitalized for continuous fever, myalgia, hypertension, vertigo and a petechial rash. laboratory findings revealed hyperglobulinaemia, thrombocytosis and a leukaemoid reaction. while on steroid therapy the patient sustained a haemorrhage into a renal aneurysm which responded to gel foam embolization. after 12 months of follow-up his condition remained stable under treatment with cyclophosphamide, prednisone and antihypertensive medic ...	2009	2881591
european collaborative trial of multifactorial prevention of coronary heart disease.		2009	2882103
[prospects of improving microbial larvicides and methods of control of blood sucking insects and disease vectors].		1987	2883565
ovarian failure after high-dose melphalan in adolescents.		2010	2884506
alopecia after immunoglobulin infusion.		2010	2884527
eicosapentaenoic and dihomo-gamma-linolenic acids.		2010	2885501
aids definition for africa.	the positive predictive values for hiv seropositivity are compared using who and us centers for disease control (cdc) clinical case definitions of acquired immunodeficiency syndrome (aids), for cases in rwanda, africa. it is postulated that the article by colebunders and co-workers should encourage clinicians and epidemiologists working in africa to adopt the world health organization's provisional clinical case definition for aids. although the predictive value for hiv seropositivity calculat ...	1987	2885595
efficacy of recombinant dna plasmodium falciparum sporozoite vaccine?		1987	2885674
partial characterization of a peptidoglycan-protein complex from fusobacterium nucleatum fev1.	a protein in the cell wall of fusobacterium nucleatum fev1 remained associated with the peptidoglycan during extraction with various detergents and organic solvents. on digestion of this peptidoglycan-protein complex (ppc) with murein hydrolases, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page) showed polypeptide bands with apparent molecular weights (mws) in the range of 3000 to 40,000. after reaction with maleic anhydride the electrophoretic mobilities of these polypeptide ...	1987	2887084
serum levels of bilirubin and biliverdin in the sea lamprey, petromyzon marinus l., before and after their biliary atresia.	1. the sera of ammocoetes, juvenile adults, and upstream migrants of the sea lamprey, petromyzon marinus l., were analyzed for the presence of the bile pigments, biliverdin and bilirubin. 2. bile pigment was not detected in the sera of ammocoetes. 3. after biliary atresia (degeneration of bile ducts at metamorphosis), bilirubin and biliverdin were detected in the sera of both juvenile adults and upstream migrants. 4. these data suggest that lampreys have some bile stasis following biliary atresi ...	2010	2887360
action of anticytoskeletal compounds on in vitro cytopathic effect, phagocytosis, and adhesiveness of trichomonas vaginalis.	the cytopathic effects of trichomonas vaginalis treated with inhibitory concentrations of anticytoskeletal compounds (mebendazole, griseofulvin, colchicine, taxol, and cytochalasin b) were studied in mouse clid fibroblast cultures. the evaluation, at different times, of cell numbers and morphological alterations showed that cytopathic effect was considerably reduced when protozoa were pretreated with mebendazole and griseofulvin, whereas colchicine, taxol, and cytochalasin b had less effect. fur ...	1987	2888725
cholinergic function and alpha-bungarotoxin binding in pc12 cells.	the cell line pc12, derived from an adrenal chromaffin cell tumor, expresses both ganglionic (c6) acetylcholine receptors (nachr) and an alpha-bungarotoxin (bgt) binding protein of unknown function. we measured nicotinic na+ fluxes of 180-260 nmol/mg protein x min and 0.35-0.8 pmol [125i]bgt binding sites/mg protein; 45-65% of the [125i]bgt binding was to intracellular sites. we blocked ganglionic na+ fluxes with reversible and irreversible inhibitors and tested whether a residual bgt-sensitive ...	2010	2890091
desensitization of beta-adrenoceptors following repeated injections of 2-substituted 4-phenylquinolines.	the chronic effects of five 2-substituted 4-phenylquinoline derivatives on the sensitivity of the noradrenergic cyclic amp-generating system in the rat brain cortex have been determined, and compared with those of the typical and atypical antidepressants imipramine and trazodone, respectively. acute treatment (single i.p. dose of 20 mg kg-1) and sub-chronic treatment (20 mg kg-1 daily for 10 days) induced no significant desensitization of the beta-adrenoceptors. however, chronic treatment (20 mg ...	1987	2890745
minimal dose (1.25 micrograms) hepatitis b vaccine for infants and newborn babies, 4 years later.		2010	2891963
[screening for tetracyclic benzodiazepines using emit-st (benzodiazepines) and tdx].	the article reports threshold ranges and detection limits for the screening of tetracyclic benzodiazepines (adinazolam, alprazolam, brotizolam, estazolam, loprazolam, midazolam, triazolam and many metabolites) using the emit-st and tdx system (fpia). in most cases, the cross reactivities of the two systems are comparable, but there are also remarkable differences. detection limits are mainly in the range between 0.2 and 0.5 mg/l but, in some cases, the limits are also considerably higher. the wi ...	2010	2893500
mechanism of proline-specific proteinases: (i) substrate specificity of dipeptidyl peptidase iv from pig kidney and proline-specific endopeptidase from flavobacterium meningosepticum.	the substrate specificity of dipeptidyl peptidase iv (dipeptidyl peptide hydrolase, ec 3.4.14.5) from pig kidney and proline-specific endopeptidase from flavobacterium meningosepticum, was investigated with a series of n-terminal unprotected (dipeptidyl peptidases iv) and succinylated dipeptidyl-p-nitroanilides (proline-specific endopeptidase). both enzymes are specific for the s configuration of the amino-acid residue in p1 and p2 position if the penultimate residue is proline. in the case of a ...	1988	2896517
involvement of prostaglandins in histamine-induced fluid and electrolyte secretion by rat colon.	histamine increased the transmural potential difference across rat colon in-vivo and induced a net secretion of fluid. both effects were inhibited by indomethacin. histamine increased the potential difference and short-circuit current, and reduced tissue resistance in colonic sheets in-vitro. this response was reduced in the absence of chloride in the bathing medium or in the presence of serosal frusemide, suggesting that histamine stimulated electrogenic chloride secretion by the colon. the ris ...	1988	2897440
the effect of metoclopramide treatment on diabetic cystoparesis.		1988	2897479
[atypical variant of cushing's syndrome].		2010	2897495
comparative efficacy of ceftriaxone and rifampicin in eradicating pharyngeal carriage of group a neisseria meningitidis.	during an outbreak of meningococcal meningitis in saudi arabia, oral rifampicin (four doses in two days) was compared with a single intramuscular dose of ceftriaxone for prophylaxis in family contacts of patients with meningococcal disease. pharyngeal samples were taken for culture before and 1 and 2 weeks after administration. both follow-up cultures indicated that ceftriaxone was significantly more effective. at 1 week the eradication rates for ceftriaxone and rifampicin were 97% and 75%; at 2 ...	1988	2897515
effects of momorcharins on ovarian response to gonadotropin-induced superovulation in mice.	alpha- and beta-momorcharins, which are abortifacient proteins isolated from momordica charantia seeds, were tested for a possible effect on ovulation and plasma levels of ovarian steroids in mice induced to superovulate by pmsg and hcg. the plant proteins did not affect follicular recruitment and maturation as evidenced by ovarian histology and serum 17 beta-estradiol level. both proteins diminished the number of oocytes ovulated when given on the day prior to or on the day of pmsg treatment, b ...	2010	2898450
neurotransmitters, cytokines, and the control of alveolar bone remodeling in orthodontics.	this article described research aimed at testing the hypothesis that tissue remodeling during orthodontic tooth movement is modulated, at least in part, by factors derived from the nervous and vascular (immune) systems. specifically, the neurotransmitters sp and vip and the cytokines il-1 alpha and il-1 beta were localized immunohistochemically in paradental tissues of cat canines that had been treated by the application of an 80 g tipping force for 1 hour to 14 days. increased staining (concent ...	1988	2900159
importance of pulmonary blood volume and aortic blood pressure in regulation of left ventricular function.		1988	2900297
changes in neurotransmitter release at a neuromuscular junction of the lobster caused by cannabinoids.	in vitro intracellular recording techniques were used on an excitatory neuromuscular junction of a walking-limb stretcher muscle of the lobster in order to define the synaptic pharmacology of delta-9-tetrahydrocannabinol (thc), 11-hydroxy-thc and cannabidiol. delta-9-tetrahydrocannabinol and 11-hydroxy-thc, in relatively small concentrations, increased the amplitude of the excitatory junctional potential and the mean quantum content of a muscle fiber, whereas larger concentrations produced depre ...	2010	2901683
phno [(+)-4-propyl-9-hydroxynaphthoxazine]: a new and effective anti-parkinson's disease agent.	phno [(+)-4-propyl-9-hydroxynaphthoxazine] is a chemically novel and highly potent dopamine (d2) receptor agonist without d1 activity. it had significant antiparkinsonism effects when used as open-label monotherapy in ten patients who were hoehn and yahr stage 2 or 3. the standard formulation of phno produced a 3- to 4-hour therapeutic effect in most patients; the response to the time-release formulation lasted up to 10 hours. side effects were similar to those of other dopamine agonists but dys ...	2010	2901697
uses of calcium channel blocking agents and beta blocking agents in the control of supraventricular arrhythmias.		2010	2902640
localization of the mdx mutation within the mouse dystrophin gene.	we have mapped human and mouse x chromosome-specific genomic and cdna probes through an interspecies mus musculus/spretus pedigree which contains the mdx mutation. the positions of these markers relative to one another and to the mdx mutation were delineated. using probes corresponding to segments of the human duchenne muscular dystrophy (dmd) gene transcript, the position of a cross-hybridizing mouse equivalent gene (mdmd) was located. in more than 200 animals mapped, three were identified whic ...	1988	2903046
thalidomide for graft-versus-host disease.		2009	2903342
comparison of the efficacy of four antihistamines in chronic urticaria.		2010	2907911
effect of growth state, tumor promoters, and transformation upon intercellular communication between c3h/10t1/2 murine fibroblasts.	diminished intercellular communication has been associated with heightened sensitivity of cultured cells to morphological transformation and enhancement of transformation by tumor promoters. microinjection of lucifer yellow dye was employed to evaluate intercellular communication between transformable c3h/10t1/2 murine fibroblasts under a variety of culture conditions. intercellular communication assayed by dye transfer from injected cells to surrounding cells in contact occurred in logarithmica ...	2010	2910519
the pre-s2 region of hepatitis b virus: more questions than answers.		1989	2912831
isolation of a corncob (coaggregation) receptor polypeptide from fusobacterium nucleatum.	corncobs, which are distinct morphological units formed by the ordered coaggregation of a filamentous microorganism and streptococci, can be made in vitro by using oral strains of fusobacterium nucleatum and streptococcus sanguis. previous studies have shown that strains of f. nucleatum contain one of at least two different types of corncob receptor. the objective of this study was to isolate the receptor from f. nucleatum atcc 10953 as the first step in the elucidation of the molecular basis of ...	1989	2912893
[clinical trials in norway].		2010	2916210
monitoring uterine activity at home.		2010	2916595
race, parental history of hypertension, and patterns of cardiovascular reactivity in women.	this study examined the interaction of race and parental history of hypertension on patterns of cardiovascular responses among women. two stressors were used that produce different patterns of cardiovascular reactivity: mental arithmetic, primarily a beta-adrenergic stimulus, and the cold face stimulus, which evokes alpha-adrenergic (i.e. vascular) activity. systolic and diastolic blood pressure, heart rate, forearm blood flow, and forearm vascular resistance were assessed before, during, and af ...	2010	2922455
extrarenal potassium adaptation: the role of aldosterone.	1. prior adaptation to a high potassium (hk) diet reduces the increment in plasma potassium after nephrectomy and acute potassium loading. previous work has suggested that this 'extrarenal potassium adaptation' is due to direct stimulation of cellular potassium uptake by chronic hyperaldosteronism. 2. in contrast, we have shown that when dietary potassium is withdrawn from hk rats, large urinary potassium losses persist, resulting in 'paradoxical potassium depletion'. this potassium depletion fa ...	1989	2924513
habituation of optically evoked blink reflex in mentally retarded adults.	this study was done to record the difference in habituation patterns of optically evoked blink reflexes in mentally retarded and normal adults. sets of photic stimuli with fixed interstimulus duration were utilized in normal volunteers and mentally retarded adults. the interstimulus duration decreased with each sequential set. the blink responses were recorded on fibreoptic recording paper. these electrophysiological methods show objectively that the blink responses to light which habituate in n ...	2010	2926795
oral flora of mongrel and beagle dogs with periodontal disease.	the plaque flora was studied in adult mongrel and beagle dogs with periodontal disease. gingival plaque from maxillary premolars was removed and cultured on various growth media. the flora in all dogs was composed of mostly anaerobic gram negative rods. bacteroides asaccharolyticus was found in the highest proportion of plaque samples from mongrel dogs, and decomposed hydrogen peroxide suggesting catalase activity. fusobacterium nucleatum was found in higher proportion in the plaque of beagle do ...	1989	2927018
ultraviolet light-induced yellowing of dental restorative resins.		2010	2931511
[occupational dermatomycoses of zoophilic origin in bulgaria].	the relative proportion of zoophilic dermatomycoses is increased in comparison with tinea capitis et pedum. the most frequent zoophilic species now is not only t. mentagrophytes, but t. verrucosum as well. occupational mycoses caused by t. mentagrophytes and t. quinckeanum in vivaria put forward new problems for experimental medicine. the author states his arguments in favour of t. quinckeanum as a separate, specialized species with reduced morphology, forming scutula. t. verrucosum is phylogene ...	1985	2933238
normal immune response to hepatitis b vaccine in patients with down's syndrome. a basis for immunization guidelines.	institutionalized patients with down's syndrome (ds) are uniquely predisposed to develop chronic hepatitis b infection following exposure. therefore vaccination is particularly warranted, but there have been concerns that these individuals may react suboptimally. we examined the immune responses of 62 institutionalized patients with ds to 20 and 40 micrograms of hepatitis b vaccine inactivated (heptavax-b) over one year. the subjects were matched by weight, age, and sex. seroconversion rates and ...	2010	2933533
[biological functions and time--the loose coupling mechanism of molecular machines].		2010	2934765
thyroxine induced transformation in sarcoplasmic reticulum of rabbit soleus and psoas muscles.	the properties of the sarcoplasmic reticulum membranes isolated from slow-twitch type i soleus and fast-twitch type ii psoas muscles of control and thyroxine treated rabbits were comparatively studied. membrane yield, maximal calcium storing capacity, atp-supported calcium uptake, calcium-dependent atpase activity and calcium-dependent phosphoprotein formation were found to be 3-10 fold higher in psoas than in soleus preparations. membrane yield, calcium-dependent atpase activity, atp-supported ...	1985	2934902
[various aspects of the etiology and pathogenesis of endocervicosis].		2010	2935043
correction of iatrogenic floating toe following resection of the base of the proximal phalanx.	for many decades, resecting the base of the proximal phalanx was a popular method of correcting hammertoes. the long-term result of the procedure, however, is a flail, proximally retracted, "floating" toe. correction of this challenging surgical problem can be accomplished with a v-y advancement flap and specific releases.	2010	2937523
oligosaccharides obtained by partial hydrolysis of lipopolysaccharide from fusobacterium nucleatum f1.		1986	2937904
first international symposium and swiss hypertension workshop on atrial natriuretic peptides. 18-19 november 1985, berne, switzerland.		2010	2941529
in vitro lipid oxidation modifies proteins and functional properties of sarcoplasmic reticulum.	changes in protein and fatty acid compositions of flounder sarcoplasmic reticulum during nadh plus ascorbate-dependent lipid peroxidation in vitro were related to the ability of the sarcoplasmic reticulum to sequester ca+2. progressive accumulation of high-molecular-weight protein components occurred concomitantly with loss of ca+2-sequestering activity. part of this polymerized protein may be the dimer or trimer of ca+2, mg+2-atpase. loss in ca+2, mg+2-atpase protein could account for over 60% ...	2010	2943730
[abnormal location of ligula intestinalis l. in scardinius erythrophthalmus l. from lake trasimeno].		1986	2944464
the effect of phenytoin on glutamate and gaba transport.	phenytoin was observed to inhibit competitively the sodium dependent high affinity synaptosomal transport of both glutamate (glu) and gamma-aminobutyric acid (gaba) with ki values of 66 +/- 10 and 185 +/- 65 microm, respectively. this contrasted with a previous report that the uptakes of glu and gaba were enhanced by phenytoin. the degree of inhibition is dependent on the concentrations of the competing drug and substrate present. taking the therapeutic levels of phenytoin and the overall brain ...	1986	2946971
aids--dental considerations. a 1986 update.		2010	2946999
an ultrastructural study of nerve cell bodies in the carotid body and common carotid artery of the domestic fowl.		1986	2948419
blood helper/suppressor lymphocyte ratio in sarcoidosis.	the blood helper/suppressor ratio was measured in 38 patients with biopsy-proved sarcoidosis. there was no relationship between this peripheral helper/suppressor ratio and the activity of the granulomatous process. this test needs further evaluation before its routine use in assessing activity in sarcoidosis.	2010	2948514
[doppler ultrasonographic study of venous diseases of the legs].		2009	2949409
[involvement of the lumbosacral trunk during delivery].		2010	2950487
[morphologic studies following coronary thrombolysis and ptca].	compared with those of other species human coronary arteries show a particularly marked diffuse thickening of the intima. superimposed on this diffuse thickening local sclerotic changes develop. in early stages they contain plenty of lipids which are mainly stored in modified smooth muscle cells, partly also in cells of monocytic origin. normally ruptures of arteriosclerotic plaques are responsible for thrombotic occlusions in extensive transmural myocardial infarctions. they are caused by ruptu ...	1986	2950674
multiple fusobacterium nucleatum liver abscesses. association with a persistent abnormality in humoral immune function.	a previously healthy 29-year-old man developed multiple hepatic abscesses secondary to fusobacterium nucleatum. no underlying local disease was found. the leading portal of entry for the bacterium may have been the oral cavity; 4 days before the onset of his illness he had had extensive dental work. immunological evaluation during the illness and in late convalescence (16 weeks after onset) revealed a persistent b cell abnormality characterized by markedly depressed in vitro secretion of immunog ...	1987	2952706
the effects of intravenous injection of alpha-human atrial natriuretic polypeptide on blood pressure, renal hemodynamics and urinary kinin excretion in anesthetized rabbits.	studies were performed in anesthetized rabbits to examine the effects of alpha-human atrial natriuretic polypeptide (alpha-hanp) on blood pressure, renal hemodynamics and urinary kinin excretion. intravenous bolus injection of alpha-hanp at a dose of 5 micrograms resulted in a transient increase in renal blood flow from 26.6 +/- 2.2 to 33.7 +/- 2.2 ml/min (p less than 0.05) and a decrease in mean arterial pressure from 113 +/- 1.8 to 107 +/- 2.2 mmhg (p less than 0.01). the calculated renal vasc ...	1987	2953089
reactive sulfhydryl groups of sarcoplasmic reticulum atpase. i. location of a group which is most reactive with n-ethylmaleimide.	ca2+-transporting atpase of rabbit skeletal muscle sarcoplasmic reticulum contains several sh groups which are reactive with n-ethylmaleimide (malnet) at ph 7.0. the location of the one which is most reactive with malnet (shn, kawakita et al. j. biochem. 87, 609 (1980)) was identified on the amino acid sequence of the atpase. shn was labeled by reacting sarcoplasmic reticulum membranes with [14c] malnet to a labeling density of 1 mol/mol atpase. [14c]malnet-labeled membranes were digested with t ...	1987	2953711
[effect of cyclophosphamide on serum complement in mice].		2010	2955665
[national commission on aids. occupational exposure].		2010	2956017
fusobacterium nucleatum-mediated immunomodulation of the in vitro secondary antibody response to tetanus toxoid and actinobacillus actinomycetemcomitans.		1987	2963111
human milk-derived lactoferrin inhibits mitogen and alloantigen induced human lymphocyte proliferation.	purified lactoferrin (lf), isolated from human milk, was tested for its effect on human t-lymphocyte proliferative responses to phytohemagglutinin (pha) and to alloantigens in mixed lymphocyte culture. lf inhibited proliferation in both assays in a dose-dependent manner. the suppressive effect was not due to lf mediated cytotoxicity since washing cells that had been pre-incubated with lf restored their proliferative activity. lf was most effective in suppressing the pha response when added withi ...	1987	2963123
survey of dental school policies on the management of patients with hepatitis b or aids.		2010	2963608
[endocrine therapy of prostatic carcinoma with slow release (depot) formulation of the lh-rh analog ici 118630 (zoladex)].	to investigate the clinical efficacy, safety and endocrinology of ici 118630 (zoladex) depot formulation at 3 different dose levels (0.9, 1.8 and 3.6 mg), 90 patients were randomized to receive either one of the 3 doses from april, 1985 to march, 1986 in 28 centers. the depot preparation was injected subcutaneously every 4 weeks 3 times (for up to 12 weeks). clinical efficacy was evaluated in terms of tumor response and overall subjective response. in 70 patients eligible for tumor response eval ...	2010	2967622
neuropsychological and neuroradiological correlates in huntington's disease.	measurements of cortical and subcortical atrophy were made on ct scans of 34 patients with huntington's disease. significant correlations were found between the bicaudate ratio (bcr) and an eye movement scale (r = 0.44, p less than 0.01), and activities of daily living scale (r = 0.57, p less than 0.001) and the mini-mental state exam (r = 0.49, p less than 0.01). no correlations were found between bcr values and severity of chorea or voluntary motor impairment. a detailed neuropsychological eva ...	2010	2976080
oestrus phases of the syrian hamster.		1988	2976222
hyperresponsiveness to water immersion in sodium retaining cirrhotics: the role of atrial natriuretic factor.	cirrhotics do not respond uniformly to head-out water immersion (hwi). some cirrhotics have an exaggerated natriuresis while others are unresponsive. we studied the humoral and urinary responses to hwi in 5 cirrhotics and compared this to 5 normals on the same 20 mm sodium intake. these cirrhotics had a documented tendency to salt and water retention but had minimal or no evidence of significant ascites. plasma levels of atrial natriuretic factor (anf) increased during immersion in both groups. ...	2010	2976331
[sideropenia: modality and length of therapy].		2010	2976346
predictors of dental behavior of disabled children.		2010	2978580
free radicals and myocardial ischemia. the role of xanthine oxidase.	recent studies have established a major role for oxygen-derived free radicals in post ischemic tissue injury to the intestine. during ischemia, there appears to be a calcium-triggered, protease-dependent conversion of the native xanthine dehydrogenase to a superoxide-producing xanthine oxidase. the catabolic degradation of atp during ischemia provides an oxidizable substrate, hypoxanthine. on reperfusion, molecular oxygen is resupplied and a burst of superoxide production ensues, resulting in ex ...	1985	2982206
bis-(diethyldithiocarbamato) copper complex: a new metabolite of disulfiram?		2010	2992526
modification of neurotransmitter receptor sensitivity in cat visual cortex during the critical period.	we have examined the characteristics of various receptors in cat visual cortex during postnatal development. these included beta-adrenergic, gaba, benzodiazepine and acetylcholine receptors. for each population of receptor the number (bmax) and affinity (kd) were examined as a function of postnatal age (3 days-adult). for all receptors examined, the bmax increased during development from low early values to a peak within the critical period. the kd also changed during development for most recept ...	1985	2994853
expression of amplified human beta interferon genes using heavy metal induction in chinese hamster ovary cells.	an expression cassette consisting of the human beta-interferon (beta-ifn) cdna fused to the human metallothionein (met)iia promoter has been linked to a selectable mouse dihydrofolate reductase gene (dhfr) and used to transform dhfr-deficient chinese hamster ovary (cho) cells. transformants resistant to increasing concentrations of methotrexate (mtx) were isolated and found to secrete beta-ifn either constitutively or upon induction with cadmium (up to 325 000 units beta-ifn/10(6) cells/24 h). m ...	1985	2996984
performance of a passive electret dosimeter for rn progeny.		2009	2999038
nucleotide sequence of the paer7 restriction/modification system and partial characterization of its protein products.	bal31 deletion experiments on clones of the paer7 restriction-modification system from pseudomonas aeruginosa demonstrate that it is arranged as an operon, with the methylase gene preceding the endonuclease gene. the dna sequence of this operon agrees with in vitro transcription-translation assays which predict proteins of 532 amino acids, mr = 59,260 daltons, and 246 amino acids, mr = 27,280 daltons, coincident with the methylase and endonuclease genes, respectively. these predicted values coin ...	1985	3001639
[cytostatic treatment of pseudomyxoma peritonei].	clinic, pathomorphology and therapy of pseudomyxoma peritonei are explained and discussed by means of a women of 54 years. the prognosis in former times very bad could be improved by a combination of radical surgery and polychemotherapy.	2011	3004068
platelet-activating factor-binding protein in human serum.	the occurrence of a kind of protein (pbp) with stronger paf-binding ability than albumin was shown in human serum. the molecular weight of pbp was approximately 160k to 180k. pbp seemed to be a pentamer composed of five 32k subunits. paf bound to pbp revealed platelet aggregation and was resistant to acetyl-hydrolase. paf synthesized in neutrophils stimulated with the ionophore a23187 was released by pbp from cells.	1985	3004155
differentiation of exercise-induced metabolic responses during selective beta 1- and beta 2-antagonism.	the effect of beta 1- or beta 2-antagonism on the plasma levels of glucose, lactate, triglycerides, and free fatty acids was studied in seventeen normal male volunteers. all subjects performed three graded and uninterrupted exercise tests until exhaustion. prior to each exercise test they received in a randomized order during three consecutive days either placebo or a predominant beta 1-blocker (atenolol, 50 mg once per day) or a predominant beta 2-blocker (ici 118,551, 20 mg t.i.d.), according ...	2010	3010028
a novel type of human papillomavirus associated with genital neoplasias.	the role of human papillomaviruses (hpvs) in the development of genital neoplasias has been well documented. the genomes of two hpv types, hpv16 and hpv18, have been found to be associated with about 70% of invasive carcinomas of the uterine cervix. as, under non-stringent hybridization conditions, hpv dna sequences have been detected in about 90% of cervical carcinomas, it seems likely that additional hpv types are associated with these tumours. here we report the molecular cloning and characte ...	1986	3012352
a second post-transcriptional trans-activator gene required for htlv-iii replication.	evidence is provided for the existence of a seventh gene in the genome of human t-lymphotropic virus type iii/lymphadenopathy-associated virus. the gene is necessary for replication and acts post-transcriptionally to relieve negative regulation of the messenger rna for the virion capsid and envelope proteins. these observations suggest mechanisms for regulating both the latent and lytic phases of the virus life cycle.	1986	3012355
coagglutination reactions between candida albicans and oral bacteria.	an agglutination assay for detecting intermicrobial adherence between the cells of candida albicans and various oral bacteria is described. strains of streptococcus sanguis, s. salivarius, s. mutans, s. mitis, fusobacterium nucleatum and actinomyces viscosus all coagglutinated with c. albicans. no interaction could be demonstrated between the cells of bacteroides melaninogenicus and those of c. albicans. preliminary investigations of these interactions suggest that binding of f. nucleatum and a. ...	1986	3018251
changing concepts in mutation research.		2010	3018767
increased interleukin-1 and modulation of interleukin-2 production by murine macrophages and lymphocytes treated with lf 1695.	previous results have demonstrated that lectin-induced t cell proliferation was potentiated or suppressed by lf 1695, a synthetic immunomodulator, depending on the dose used. therefore the activity of this compound was investigated on murine il-1 and il-2 production. adherent peritoneal cells, incubated with lf 1695, could secrete high levels of il-1 with only a slight elevation in intracellular il-1. this effect apparent at 5 and 10 micrograms/ml was linked to a transient state of activation. a ...	2010	3019905
increased interleukin-1 and modulation of interleukin-2 production by murine macrophages and lymphocytes treated with lf 1695.	previous results have demonstrated that lectin-induced t cell proliferation was potentiated or suppressed by lf 1695, a synthetic immunomodulator, depending on the dose used. therefore the activity of this compound was investigated on murine il-1 and il-2 production. adherent peritoneal cells, incubated with lf 1695, could secrete high levels of il-1 with only a slight elevation in intracellular il-1. this effect apparent at 5 and 10 micrograms/ml was linked to a transient state of activation. a ...	2010	3019905
physical mechanism for inactivation of metallo-enzymes by characteristic x-rays.	measurements have been made of the inactivation of the metallo-enzyme dihydro-oratic dehydrogenase in solution by characteristic x-rays at energies above and below the k absorption edge of the constituent iron atom. from the dose-survival curves and knowledge of the equilibrium electron spectrum generated by the x-ray 'field', inactivation cross-sections are deduced and expressed in terms of intrinsic efficiencies for the various proposed direct and indirect mechanisms of inactivation. it is con ...	2010	3019913
physical mechanism for inactivation of metallo-enzymes by characteristic x-rays.	measurements have been made of the inactivation of the metallo-enzyme dihydro-oratic dehydrogenase in solution by characteristic x-rays at energies above and below the k absorption edge of the constituent iron atom. from the dose-survival curves and knowledge of the equilibrium electron spectrum generated by the x-ray 'field', inactivation cross-sections are deduced and expressed in terms of intrinsic efficiencies for the various proposed direct and indirect mechanisms of inactivation. it is con ...	2010	3019913
chromosome damage induced by herpes simplex virus type 1 in early infection.	the chromosome damage induced by herpes simplex virus type 1 (hsv-1) in vitro was examined up to 6 h after infection using ht-1080 cells. initial damage occurring within 3 h was specific, involving uncoiling of chromosome 1q12-21 and to a lesser extent the pericentric regions of chromosomes 9, 16 and satellited chromosomes. for the initial unwinding, synthesis of the immediate early class of hsv proteins needed to occur as was demonstrated using hsv-1 temperature-sensitive mutants tsk and tsb7 a ...	1986	3020163
[nuclear magnetic resonance spectroscopy in medicine: biochemistry of intact tissues].		1986	3020443
[nuclear magnetic resonance spectroscopy in medicine: biochemistry of intact tissues].		1986	3020443
a computer-aided analysis of the effect of peripheral nerve transection on tmpase activity of substantia gelatinosa rolandi.		1986	3020818
[value of computerized tomography in the evaluation of the operability of bronchial cancers].	65 computer tomographs were taken of 79 patients with bronchial carcinoma for the purpose of determining operability. included were 49 computer tomographs of the thoracic region, 7 of the epigastrium, and 9 of the skull. ct, a noninvasive radiological diagnostic method, was used in the above cases not only for diagnosis but even more for high-accuracy staging and thus therapy planning. ct accuracy regarding assessment of local operability amounted to 97.9 per cent (n = 49). there was only one ca ...	2010	3020839
methylcholanthrene: a possible pseudosubstrate for adrenocortical 17 alpha-hydroxylase and aryl hydrocarbon hydroxylase.	in cultured bovine adrenocortical cells, loss of 17 alpha-hydroxylase activity was observed after incubation with 3-methylcholanthrene (3-mc). the suppression of 17 alpha-hydroxylase by 3-mc was rapid (50% loss of activity in 10 hr at 1 microm 3-mc), did not exhibit a lag period, and was not affected by cycloheximide. direct effects of 3-mc on 17 alpha-hydroxylase were observed only at high concentrations, but the concentration for 50% loss of activity was 0.3 microm when 3-mc was added for 24 h ...	1986	3021165
regulation of guinea-pig immune functions by interleukin 2: critical role of natural killer activity in acute hsv-2 genital infection.	we have previously demonstrated that recombinant interleukin 2 (ril 2) has a protective effect against acute hsv-2 infection in guinea pigs with a biphasic dose response which peaked between 4 and 20 x 10(4) u/kg, whereas 8 x 10(5) u/kg showed no effect on disease. animals that escaped infection appeared lack immunologic memory to hsv-2, suggesting a nonspecific immune mechanism. in this study we have found that nk activity of fresh splenocytes measured against hsv-2 infected human foreskin fibr ...	1986	3021853
detection of dihydroorotate dehydrogenase activity as a marker of de novo nucleic acid synthesis in germinal centers of spleens following antigen administration.	a histochemical technique, developed for the localization of dho-d activity in tissue, has been utilized to study the distribution of this activity in rabbit spleen. this enzyme is involved in the de novo synthesis of pyrimidines of nucleic acids via orotic acid as an intermediate. the enzyme was found to be most active at the periphery of follicles in the resting spleen. following antigenic challenge, enzyme activity became prominent for several days in macrophages within germinal centers, but ...	1985	3023585
characterization of benzodiazepine receptors in the bovine pineal gland: evidence for the presence of an atypical binding site.	bovine and rat pineal benzodiazepine receptors were characterized using ligands with high affinities for either 'central-type' (cbr) or 'peripheral-type' (pbr) benzodiazepine receptors. the characteristics (bmax = 83 +/- 10 fmol/mg protein, kd = 3.88 +/- 0.46 nm) of benzodiazepine receptors in bovine pineal membranes measured with [3h]flunitrazepam (using flunitrazepam to define non-specific binding) were consistent with previously reported values. however, if non-specific binding was defined us ...	1986	3024779
characterization of benzodiazepine receptors in the bovine pineal gland: evidence for the presence of an atypical binding site.	bovine and rat pineal benzodiazepine receptors were characterized using ligands with high affinities for either 'central-type' (cbr) or 'peripheral-type' (pbr) benzodiazepine receptors. the characteristics (bmax = 83 +/- 10 fmol/mg protein, kd = 3.88 +/- 0.46 nm) of benzodiazepine receptors in bovine pineal membranes measured with [3h]flunitrazepam (using flunitrazepam to define non-specific binding) were consistent with previously reported values. however, if non-specific binding was defined us ...	1986	3024779