Publications

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the relative significance of spinal cord norepinephrine and 5-hydroxytryptamine in electrically-induced seizure in the rat. 1978148011
hormonal regulation of ovarian folliculogenesis in rhesus monkeys: i. concentrations of serum luteinizing hormone and progesterone during laparoscopy and patterns of follicular development during successive menstrual cycles. 1978149571
[n[2-hydroxyethyl] palmitamide repeated administration effect on interferon production in mouse organism after phage double-stranded ribonucleic acid [ds-rna] application (author's transl)]. 1978149599
[new data on serotonin control of sexual receptivity in the rat].serotonin was shown to be involved in the mechanisms whereby olfactory bulbs controlled sexual receptivity between 18 and 19 hrs. on prooestrus in 4-day cyclic female rats.1978149613
polyamine-induced actin polymerization.muscle actin has been found to polymerize reversibly upon addition of low concentrations of polyamines. this polymerization, studied by centrifugation, has shown a linear relationship between the actin polymerization yield and the chain length of the polyamine. among the biological polyamines tested, spermidine and spermine are the most efficient. the polymerization of actin can also be induced by the corresponding mono or diguanidine derivatives of these polyamines but monoamines or amino acids ...1978149658
[the effect of concomitant administration of dehydroepiandrosterone with progesterone on decidual growth in the rat (author's transl)].studies were made on the effect of concomitant administration of dehydroepiandrosterone acetate (dha-ac) with progesterone on decidual growth in the rat. virgin female rats of wistar strain weighing about 250 g were used. daily vaginal smears were recorded and, during the time of vaginal cornification, the animals were made pseudopregnant by tapping the uterine cervix. day 1 of the pseudopregnancy was designated as the day that the vaginal smears contained primarily leucocytes. on day 4 of the p ...1978149679
effect of human immunoglobulin preparations on fc rosette formation between anti-d-coated erythrocytes and lymphocytes.human immunoglobulin (ig) preparations were tested for their inhibitory effect on fc rosette formation between anti-d-coated human erythrocytes and lymphocytes, as compared to their complement activating capacity. both of the two biological activities ascribed to the sites in the fc portion of the igg molecules were found to be reduced in the pepsin-treated, as well as in the s-sulfonated ig preparations, as compared to the activities of the normal human ig preparation. in the plasmin-treated ig ...1978150144
structure of alpha-polymer from in vitro and in vivo highly cross-linked human fibrin.peptides derived from plasmic and cyanogen bromide (cnbr) cleavage of highly cross-linked fibrin were isolated and characterized by sodium dodecyl sulfate-gel electrophoresis, amino acid analyses, cyanoethylation, and nh2-terminal analyses. extended plasmic digestions of human fibrin containing four epsilon-(gamma-glutamyl)lysine cross-links per molecule produced a peptide of alpha-chain origin (mr congruent to 21,000) which was comprised of a small donor peptide cross-linked to the acceptor sit ...1978150419
[raised prostaglandin e-2 level in focal inflammatory lesions of the human skin with particular reference to rosacea]. 1978151301
[morphological changes in the digestive organs during prolonged space flight on the kosmos-782 biosatellite].a reduction in the content of neutral mucopolysaccharides in mucous cells of the neck, a slight decrease in the activity of succinate dehydrogenase and nad-diaphorase in parietal cells, a decrease in the dna synthesis rate, and an increase in the area of mitochondria and cristae were detected in the gastric mucosa of rats which were in a long-term space flight. in the small intestine, an increase in the activity of glucose-6-phosphate dehydrogenase and leucine aminopeptidase were found. morpholo ...1978152100
chlamydia trachomatis in gonococcal and postgonococcal urethritis.chlamydia trachomatis was isolated from the urethra of 38 (28.6%) out of 133 men with gonococcal urethritis (gu). during the follow up of 72 men postgonococcal urethritis (pgu) was diagnosed in 50 (69.5%) patients. more than half (30 out of 50) of these patients with pgu were chlamydia-positive. out of 31 patients with chlamydia 30 developed pgu whether or not procaine penicillin, spectinomycin, or gentamicin were used. these findings are discussed in relation to present recommendations for the ...1978152142
guinea-worm infection in banaskantha district of gujarat--some important epidemiological aspects. 1978153328
comparison of thymidine, fluorodeoxyuridine, hydroxyurea, and methotrexate blocking at the g1/s phase transition of the cell cycle, studied by replication patterns.cultures of human amniotic fluid cells and fibroblasts were temporarily blocked by the replication inhibitors thymidine (dt) surplus, fluorodeoxyuridine (fdu), hydroxyurea (hu), or methotrexate uridine (mu). the respective arresting point at g1-s transition and the homogeneity of the blocked cell population were determined by means of brdu replication patterns. most variation of patterns were found after hu. after mu, cells were arrested before the onset of replication, while with dt surplus of ...1978153886
isolation of neurospora crassa-bovine l-glutamate dehydrogenase hybrids [proceedings]. 1978154423
isolation of neurospora crassa-bovine l-glutamate dehydrogenase hybrids [proceedings]. 1978154423
assembly of the mitochondrial membrane system: partial sequence of a mitochondrial atpase gene in saccharomyces cerevisiae.the nucleotide sequence of mitochondrial dna of a cytoplasmic "petite" mutant of saccharomyces cerevisiae is reported. the dna has a repeat length of 1060 base pairs and contains a genetic marker (oli-1) for the atpase proteolipid. the nucleotide sequence reveals the presence of part of the structural gene of the subunit-9 proteolipid of the atpase complex and an extended a+t-rich region adjacent to the carboxyl-terminal end of the gene. the structural gene sequence agrees with the primary struc ...1979154670
[effect of propyl-2-pentene-2-oic acid on gaba levels in different regions of mouse brain].an elevation in cerebral gaba level (65%) is observed after administration of an anticonvulsant, sodium propyl 2-pentene-2 oate, a branched chain fatty acid, comformationally restricted gaba analogue, competitive inhibitor of gaba-t in regard to gaba. the concentration of gaba increases in some regions i.e. substantia nigra, frontal and temporal cortex, cerebellum and olfactory bulbs. the gaba level remains unchanged in caudate nucleus, hippocampus and occipital cortex. results are discussed com ...1978154951
[dwarf colony mutants of escherichia coli: plasmids resistant to antibiotics].deficient dwarf colony (ddc) mutants of e. coli k 12, harboring or no resistance plasmids, were obtained in vitro. the r plasmids of parental strains and to ddc mutants were transfered by conjugation to normal colony, and to ddc mutants of e. coli k 12; the frequencies of transfer were similar for all strains studied.1978154954
chemistry and pharmacokinetics of ipratropium bromide. 1979155287
[changes in allogeneic immune response of swine in the course of a liver allograft].pig liver allografts showed a typical rejection crisis. the degree of rejection depended on the sla-typing. despite sla-incompatibility pig liver allografts can be tolerated. short-term survivors showed an immunological hyporeactivity. long-term survivors reconstituted their cellular immune-reactions and developed an antibody which appeared to function as an antigen-antibody-complex or an anti-ia-antibody.1977156111
inhibition of in vitro cytotoxic responses by bcg-induced macrophage-like suppressor cells. ii. suppression occurs at the level of a "helper" t cell. 1979156233
seeding endothelium onto canine arterial prostheses. the effects of graft design.to identify prosthetic characteristics that support the proliferation of an endothelial lining, 14 different graft designs were studied in dogs. the grafts were prepared by the use of a technique of endothelial seeding that we described previously. they were studied two and four weeks after their implantation. weft-knit dacron grafts (water porosity from 1,400 to 1,650 ml/min/sq cm) were the most successful. a velour index (velour stitch frequency times velour loop height) was computed. when the ...1979156532
changes in the immunoglobulin levels of the mouse gut and serum during conventionalisation and following administration of salmonella typhimurium.increasess in all immunoglobulin classes, except igm, were observed in the sera of specific pathogen-free (spf) mice beginning 10 days after their removal from barrier conditions. concentrations of serum immunoglobulins, comparable with those of conventional mice, were obtained in these animals between 21 and 35 days. following the removal of germ-free mice from their sterile isolaters, their intestinal iga levels increased over 35 days to attain levels found in conventional animals. a marked in ...1978156538
gonococcal urethritis--diagnosis and treatment.for men with urethral discharge, a simple gram stained smear is 98% sensitive and over 99% specific in detecting gonococcal infection when compared to a single thayer-martin culture. the smear is less than 50% sensitive in asymptomatic urethritis. neither fluorescent antibody nor various serologic tests offer any diagnostic advantages over smears and/or cultures and they are not cost-effective. treatment of gonococcal urethritis may be successfully accomplished with a variety of antibiotic regim ...1979161160
acute perihepatitis.fourteen young females with acute pains in the right hypochondrium were admitted to the surgical department. the history and clinical findings were typical of acute perihepatitis (fitz-hugh-curtis syndrome), and the diagnosis was confirmed by laparoscopy. the gynecological symptoms and signs were negligible, and neisseria gonorrhoeae were cultured from the endocervix in two of the patients. pathogenes in the suprahepatic space were not demonstrated. eight patients used intrauterine contraceptive ...1979161459
the cornea in normal condition and in groenouw's macular dystrophy. 1979161528
effect of oral contraceptive containing a new progestin (org 2969) on plasma renin activity, growth hormone and immunoreactive insulin.plasma renin activity (pra), growth hormone (gh) and immunoreactive insulin (iri) were studied in seven healthy subjects during the ovulatory menstrual cycle and during the first and third cycles of oral contraception with 0.05 mg of ethinylestradiol and 0.100 mg or 0.125 mg of a new progestogen, 17 alpha-ethinyl-18-methylene-4-estren-17 beta-ol. the pra level in the second half of the control cycle was significantly higher than in the beginning of the cycle. at the end of the treated cycles it ...1979161858
in vitro assays of the efficacy of antimicrobial agents in controlling chlamydia trachomatis propagation.the antimicrobial susceptibility of a low-laboratory-passage, slow-growing, genital chlamydia trachomatis strain was studied by five different procedures with the use of mccoy cells pretreated with 5-iodo-2-deoxyuridine. the effects of antimicrobial agents when added to cultures on day 0 or day 2 after inoculation with c. trachomatis and the effects of washing and reincubating treated cultures in antimicrobial-free media were investigated. tetracycline and erythromycin inhibited c. trachomatis g ...1978162541
[the immunglobulin-content of human parotid saliva (author's transl)].by means of radial immundiffusion, the content of iga, igg, igm and ige in 22 healthy persons was measured. the parotid saliva has been collected under standardized stimulation-conditions in 10 minutes-fractions during a time of 30 minutes. while igm and ige could not be found with this method, iga and igg were present in a concentration easy to be measured. for the two immunglobulins, a different and characteristical change in their concentration was found during stimulation. this difference ca ...1975162620
cellulase location in cellvibrio fulvus.the location of cellulase in c. fulvus depends on the carbon source for growth and the age of the culture. when cells were grown on glucose or cellobiose all cmc-hydrolyzing enzyme was cell-bound but only part of the activity was located on the cell surface. treatment of cells with edta, lysozyme, and detergents and subsequent fractionation experiments showed that cellulase was also located in the periplasm and bound to a membrane fraction. growth on cellulose gave cell-free cellulase active aga ...1975163668
translation of individual species of vesicular stomatitis viral mrna.vesicular stomatitis virus mrnas from three of the four bands fractionated by polyacrylamide gel electrophoresis in 99% formamide have been eluted from gels and translated in the krebs ii ascites cell-free system. band 2 mrna (0.7 times 10-6 daltons) directed the synthesis of the protein moiety of the glycoprotein (g), and band 3 (0.55 times 10-6 daltons) coded for the nucleocapsid (n) protein. band 4 mrna (o.28 times 10-6 daltons) directed the synthesis of the ns and matrix (m) proteins. the au ...1975163911
simian virus 40-related antigens in three human meningiomas with defined chromosome loss.two out of seven meningiomas tested in early cell cultures by indirect immunofluorescence staining showed simian virus 40 (sv40)-related tumor (t) antigen. in one tumor 90% of the cells were positive. an additional sv40-related antigen (u) was found in 10% of cells of a third tumor. these findings indicate that the meningioma cells showing a positive reaction are transformed by a papova virus that has at least partly the same antigenic properties as sv40 virus. sv40-related viral capsid (v) anti ...1975164660
nadh fluorescence and [k+]o changes during hippocampal electrical stimulation.1. short (2 s) trains of stimuli were applied to the dorsal hippocampal surface of cats, producing an increase in [k+]o and a decrease in nadh fluorescence (the latter being indicative of an increase in tissue oxygen utilization). 2. the [k+]o rose rapidly during stimulation (delta[k+]o values from 1 to 6 mm) with larger stimulus currents producing larger changes. the time course of the poststimulus decline of [k+]o was an exponential decay function, with t 1/2 values varying from 1.3 to 6.9s, a ...1975165273
detection of oncornavirus antigenic activity in human urothelial tissues.our studies indicate that certain urologic tissues demonstrate evidence of proteins which compete with the interspecies antigens of c-type ribonucleic acid viruses for binding sites of the feline and murine oncornavirus antiglobulins. this fact indicates either the association of viral antigens within these tissues or the presence of a protein so similar to the interspecies antigen that it cross reacts. studies are now underway to localize reacting antigens within these urologic cells, to correl ...1975165323
determination of sedoheptulose 7-phosphate. 1975165386
etiology of nongonococcal urethritis.chlamydia trachomatis was isolated from the urethra from 48 (42 per cent) of 113 men with non-gonococcal urethritis (ngu), four (7 per cent) of 58 without overt urethritis, and 13 (19 per cent) of 69 with gonorrhea. postgonococcal urethritis (pgu) developed in 11 of 11 men who had c. trum antibody to c. trachomatisis developed. the immunotype specificity of chlamydial antibody corresponded to the immunotype isolated. among culture-negative patients. chlamydial antibody prevalence correlated with ...1975165407
letter: petechiae: due to adenovirus type 7 infection or to acetylsalicylic acid therapy? 1975165451
modification of surface membrane antigens by trypsin.cultured 3t3 and py-3t3 mouse fibroblasts were subjected to mild treatment with twice crystallized trypsin and their immunogenicity tested in icr/cd-1 mice. surface antigenic modifications were observed using the foot pad swelling assay for detection of delayed hypersensitive responses. mice immunized with trypsin-treated 3t3 cells showed cell-mediated immune reactions following challenge with either homologous antigen or untreated py-3t3 fibroblasts. in contrast, treatment of the virus-transfor ...1975165549
lipolysis and cyclic amp accumulation in isolated fat cells from chicks. 1975166018
immunodeficiency in the chicken. ii. production of monomeric igm following testosterone treatment or infection with gumboro disease.chickens were treated at an early embryonal age with testosterone propionate or infected neonatally with the virus producing gumboro disease. their sera were subsequently fractionated by sephadex g-200 chromatography, and showed a complete deficiency of igg and the presence of igm which was eluted with the 7s protein fraction. purified and 125-i-labelled monomeric igm was examined by sds-acrylamide gel electrophoresis and found to contain both mu and light chains, together with a chain of interm ...1975166037
viable vein graft preservation. 1975166254
isolation of a glycogen synthase i kinase that is independent of adenosine 3':5'-monophosphate.three protein kinases (atp:protein phosphotransferase, ec 2.7.1.37) were detected when the soluble fraction of rabbit kidney medulla was chromatographed on deae-cellulose with a linear nac1 gradient. the first two kinases eluted (peak 1 and peak ii) were cyclic-amp-dependent, wheras peak iii was cyclic-amp-independent. a procedure was developed to separate the catalytic subunit of peak ii cyclic-amp-dependent protein kinase (representing the bulk of the histone kinase activity) from peak iii pro ...1975166380
influence of peptides on reduced response of rats to electric footshock after acute administration of morphine.acute treatment of rats with morphine (10 mg/kg) resulted in a marked reduction of motor response to inescapable electric footshock (efs). nalorphine (2mg/kg) antagonized this action of morphine. pretreatment with synthetic acth 1-24 (10 iu) 60 min prior to testing also inhibited this morphine-induced reduction, whereas other acth-like peptides, lacking corticotrophic activity, were ineffective. acth 1-24 had no effect on the response of adrenalectomized rats to efs after morphine. in intact rat ...1975170120
histological and combined chemoimmunostimulation therapy studies against a murine leukemia.a graffi murine leukemia was utilized as a model system to investigate the effect of chemoimmunostimulation therapy. subcutaneous inoculation of approximately 1.0 times 10(6) tumor cells resulted in a rapidly growing tumor at the site of inoculation and subsequent development of splenomegaly and lymphoadenopathy. all animals succumbed to the leukemia within 24 to 30 days. treatment of diseased animals with two courses of cytoxan over a 2-week period resulted in a remission period of approximatel ...1975170212
[properties of recently isolated bordetella pertussis]. 1975170434
[ultrastructure of human hepatocytes in early prenatal ontogenesis].the structure of hepatic cells was studied in 40 human embryos and fetuses from 4 to 16 weeks of intrauterine development. depending on the differentiation degree of organells and their amount in the hepatic cell of the embryo and fetus three types of hepatic cells are distinguished: slightly differentiated, transitional and differentiated cells. in the course of early prenatal ontogenesis the amount of slightly differentiated hepatic cells diminishes and the amount of transitional and different ...1975170891
inhibition of in vitro growth of lymphoma cells by macrophages from tumor-bearing mice.spleen cells from c57bl/6 mice bearing primary tumors induced by the moloney strain of murine sarcoma virus (musv) strongly inhibited the uptake of tritiated thymidine (3h-tdr) by rbl-5 lymphoma cells in a 48-hour growth-inhibition assay (gia). this activity was first detected 7 days after musv was injected; it peaked at 14 days, and was usually no longer detectable after 18-21 days. it could be detected at effector cell/target cell ratios between 20:1 and 5:1, at which normal spleen cells had a ...1975171434
biochemical and biophysical characteristics of diarrhea viruses of human and calf origin.polyacrylamide gel electrophoretic analysis of purified preparations of human and calf diarrhea viruses indicated eight polypeptide components, or possibly nine in the case of the calf diarrhea virus. thermal denaturation and analytical studies of the calf diarrhea virus genome showed it to consist of 11 double-stranded segments of rna. the placing of the human and calf diarrhea viruses together with other similar viruses into a genus separate from reovirus and orbivirus, but within the family r ...1975171450
genetics of natural resistance to herpesvirus infections in mice. 1975171586
molecular weights of adrenocorticotropic hormone in extracts of anterior and intermediate-posterior lobes of mouse pituitary.the molecular weight of the adrenocorticotropic hormone (acth) activity in extracts of the separated anterior and intermediate-posterior lobes of the mouse pituitary was determined by gel filtration in guanidine-hcl. following dilution or removal of the guanidine-hcl, acth activity was quantitated by both radioimmunoassay and bioassay. extracts of the intermediate-posterior lobe contain approximately a tenth as much acth activity as extracts of the anterior lobe. in extracts of both the anterior ...1975171667
dependence of gonadotropin-induced steroidogenesis upon rna and protein synthesis in the interstitial cells of the rat testis.the effects of inhibitors of rna and protein synthesis upon gonadotropic stimulation of testosterone and cyclic amp production by the leydig cellwere investigated in vitro with enzyme-dispersed interstitial cells of the rat testis. the testosterone response to human chorionic gonadotropin was abolished by cycloheximide and puromycin, and was markedly reduced by actinomycin d and cordycepin. during 3-h time studies, cycloheximide caused complete inhibition of subsequent steroid production when a ...1975172138
studies on epsilon-prototoxin of clostridium perfringens type d. physicochemical and chemical properties of epsilon-prototoxin.epsilon-prototoxin of clostridium perfringens type d consists of one polypeptide chain of 311 amino acids with the following composition: asp52 thr31 ser25 glu28 pro12 gly17 ala14 val28 met5 ile15 leu18 tyr17 phe8 lys31 his2 arg5 tyr2. it has no free cysteine but contains one blocked cysteine. the n-terminal as well as the c-terminal residue is lysine. the ultracentrifuge pattern gave one single boundary having s020,w = 2.15 s and do20,w = 5.56-10(-7) cm2/s. calculation of the molecular weight f ...1975172146
direction-selective units in the rabbit's nucleus of the optic tract.a class of direction-selective (ds) units, histologically localized within the nucleus of the optic tract (not) was isolated in the rabbit's pretectum. these units typically had a maintained discharge of 25-50 action potentials/sec and large receptive fields (up to 40 x 150 degrees) in the visual streak area of the contralateral eye. they were excited by a visual pattern moving in one direction and inhibited by motion in the opposite direction. the reactions were sustained. excitatory and inhibi ...1975172194
localization of adenylate cyclase in dictyostelium discoideum. i. preparation and biochemical characterizations of cell fractions and isolated plasma membrane vesicles. 1975172348
elevation of intracellular calcium ion concentration provokes production of 1,2-diacylglycerol and phosphatidate in human erythrocytes. 1975172387
pain. a central inhibitory balance theory.knowledge of the segmental neuronal circuitry for noxious and non-noxious input is a necessary prelude to understanding pain mechanisms. significant gaps in our understanding of the synaptology of these pathways in the dorsal horn have hindered progress in this area. this report describes the excitatory and inhibitory circuits that supply the marginal neurons of the spinal cord, whose role in nociceptive mechanisms is well established. on the basis of these data, it is proposed that large prima ...1975172744
effect of insulin induced hypoglycemia on acth, cortisol, and growth hormone release in man. 1975172820
herpes genitalis in guinea-pigs. ii. morphological studies in female guinea-pigs infected with herpesvirus hominis type 2.gross and microscopial morphological changes developing in female guinea-pigs after vaginal infection with hvh 2/angelotti were studied. in the mucosa of the external genital tract there were inflammatory changes with formation of intra-epithelial vesicles, erosions and ulcerations. in the late stages of the infection signs of inflammatory dysplasia were also observed. the infection spread into the nervous system and produced characteristic inflammatory changes. the inflammation began as a bilat ...1975172947
the relationship of sleep and sleep stages to neuroendocrine secretion and biological rhythms in man. 1975172995
[study of the interrelationship between the content of immunizing units and the immunogenicity of c1. perfringens anatoxins].comparative experiments were conducted on rabbits and guinea pigs; a study was made of the immunological efficacy of the toxoids with a different content of the immunizing units (iu/ml). there was revealed a regular quantitative interrelationship between the content of the iu/ml in the toxoids, the level of the antitoxin formation and the extent of protection against the experimental gas gangrene in the immunized animals.1975173119
function of ascorbic acid in collagen metabolism. 1975173224
[formation of polysomes in virus-specific rna in the transcriptive complex of sendai virus infected cells].transcriptive complex in the cytoplasm of sendai virus infected cells included parental rna in the form of ribonucleoprotein, nascent rna and polysomes. its buoyant density in csc1 was 1.45 g/ml. the complex dissociated three hours after the infection, and nascent rna was fully separated from the parental rnp. the template for polysomes within the complex was identified under conditions when the complex was dissociated in cycloheximide-treated cells. polysomes were revealed in the association wi ...1975173426
the complement system in cryoglobulinaemia. interaction with immunoglobulins and lipoproteins.serum from a patient with an igm-lipoprotein cryoglobulin, both before and after removal of the cryoprecipitate at 0 degrees c, had extremely low levels of whole complement (c), c1, c4 and c2, while amounts of the remaining components were normal or only slightly reduced. the cryopredipitate, when added to fresh normal human serum, reproduced this pattern of c fixation. separation of the patients's serum at 37 degrees c into its lipoprotein, igg and igm fractions revealed that the igm alone woul ...1975173488
cytopathic effects in primary epithelial cultures derived from the human prostate.normal, benign, and malignant human prostatic tissue was cultivated in vitro. cytopathic effects in derived epithelial cells were examined. light microscopy revealed polykaryocyte formation, vacuolation, cytoplasmic bridges and processes, nuclear inclusions, increased acid phosphatase activity at the cell membrane of polykaryocytes as compared to mononuclear cells, and cell rounding and clumping. electron microscopy of the polykaryocytes showed nuclear membrane proliferation and protrusion, scar ...1976173669
anti-viral activity of single-stranded homopolynucleotides against encephalomyocarditis virus and semliki forest virus in adult mice without interferon induction.single administrations of poly c or poly i are anti-viral against infections of encephalomyocarditis (emc) and semliki forest virus (sfv) in mice but poly u and poly a are not. the degree of protection is dose-dependent and mice which die do so at a later time when untreated controls even in a strain of mouse in which the time of death is not dependent on the dose of virus given. no circulating interferon is found after treating mice with poly c or poly i even at polynucleotide doses which give ...1976173799
effect of "drugs for liver disease" on hepatotoxic action of carbon tetrachloride. i. changes of lysosomal enzyme levels and effect of protoporphyrin on the levels.in order to clarify the action of drugs for liver disease, the effect of protoporphyrin (pp) on ccl4-induced liver injury was studied. attention was given to the levels of lysosomal enzymes, some components of the liver, and inhibition of enzymes and lysis of lysosomal membranes by lipid peroxides. administration of pp to ccl4-poisoned rats was found to prevent the decrease in lysosomal lipolytic enzyme level in the liver, but not in other enzyme levels tested. the inhibition of lipolytic enzyme ...1975173910
incorporation of [3h] leucine into brain stem protein fractions: the effect of a behaviorally active, n-terminal fragment of acth in hypophysectomized rats.in hypophysectomized rats, the incorporation of [3h] leucine into rat brain stem protein, measured 5 min after injection of the precursor into the diencephalon, was decreased. chronic treatment of these rats with the n-terminal fragment of acth, acth1-10 increased the incorporation rate. brain stem proteins were sequentially extracted with a hypotonic buffer, triton x-100 and sds. analysis of these protein fractions on polyacrylamide gels revealed that hypophysectomy caused a general decrease in ...1975174020
arterial metabolism in primates. 1976174070
cell-mediated immunity to virus-induced tumors: generation of lymphocytes sensitized to specific transplantation antigen in mouse cells infected with papovavirus sv40. 1975174151
[some physicochemical properties of the dysenteric therapeutic--prophylactic newcastle phages h-17 and h-18 (author's transl)].some physico-chemical properties of dysentery therapeutic-prophylactic newcastle-phages h-17 and h-18 were studied. both phages were shown to be resistant to sodium dodecyl sulphate at room temperature. phage h-17 at room temperature was completely inactivated and phage h-18 inactivated by 40% by 1 m sodium hydrochloride. phage h-18 was completely inactivated by 4 m sodium hydrochloride. morphology and sizes of the phages are described. the buoyant density of phage h-17 was found to be 1.497 g/c ...1975174322
relationships of foreign protein injections (hyposensitization) in atopic children to serum lipids and lipoproteins.foreign protein injections (hyposensitization) given for one year to human asymptomatic asthmatics did not increase their serum total lipids or lipoprotein levels, as they apparently did in rabbits fed a lipid-rich, cholesterol-poor diet. serum total protein and immunoglobulin levels for iga, igm and igg for the asthmatics and controls were no different.1976174460
immunoglobulins, antibodies and inhibitors of parainfluenza 3 virus in respiratory secretions of sheep.virus neutralising and haemagglutination inhibiting (hi) activities were monitored in the serum, nasal secretions and tracheo-bronchial secretions of lambs infected with parainfluenza virus type 3 (pi3). hi activity was found in the secretions of both control and infected lambs, whereas neutralising antibody was found only in nasal secretions from infected lambs. fractionation revealed that most of the hi activity in the secretions was due to a large molecular weight protein which also inhibited ...1975174528
natural and experimental infections of japanese tree sparrows with japanese encephalitis virus.20 to 37 per cent of wild japanese tree sparrows had neutralizing antibodies to japanese encephalitis virus (jev). sparrows free of antibodies were inoculated with 10,000 plaque-forming units of jev. none of the birds became clinically ill. virus could be detected in blood plasma during the first 3 days after inoculation but not thereafter. neutralizing antibodies started to appear at 4 days after inoculation and the response was of variable duration, in some cases extending up to 200 days after ...1975174531
[characteristics of testosterone-binding cytoplasmic components in the human endometrium and their interaction with chromatin].the existence of macromolecules which specifically bind 3h-testosterone is demonstrated in the soluble fraction of human uterus endometrium. testosterone receptors of endometrial cytosol are heterogenous and comprise the component with high affinity (kd--2,9x10(-10) m) and low capacity (concentration of binding sites--0,5 pmoles per mg of protein) and the component with lower affinity and higher capacity (4x10(-9) m and 4 pmoles/mg of protein respectively). incubation of sliced of endometrium at ...1975174756
similarities of the golgi apparatus membrane and the plasma membrane in rat liver cells.a golgi apparatus-rich fraction and a plasma membrane-rich fraction were isolated from a common homogenate of rat liver. their respective buovant densities, appearances in the electron microscope and 5'-nucleotidase and udp-galactose ovalbumin galactosyltransferase activities were in accord with published data on separately isolated golgi apparatus-rich and plasma membrane-rich fractions. contamination by endoplasmic reticulum and mitochondria was low. gel electrophoresis of the membrane protein ...1976175074
the macromolecular organization of the elastin fibril. 1976175164
catecholamine-induced cyclic amp and morphologic alteration in glioma cells. 1975175296
[laser applications in neurosurgery (author's transl)]. 1975175311
induction of smon-type virus form avian infectious laryngotracheitis virus.smon-type virus which shows different host range was induced from ilt virus under unsuitable culture conditions for the growth of the parental ilt virus, such as cultivation in cam of 12-day-old eggs or cultivation in chk cells at 32 degrees. furthermore, it was induced from ilt virus by mutagenesis by either brdu or ng in chk cell cultures.1976175380
[an epidemic of meningitis caused by coxsackie a9 virus in the city of wrocław in 1974]. 1975175404
regulation of myocardial energy metabolism.closed aorta working hearts perfused with 1 mm pyruvate were subjected to a 4-fold increase in work load by raising the left atrial filling pressure. citric acid cycle flux, pyruvate uptake, and oxygen consumption rose 3-fold when cardiac output was increased. in the first 40 sec after the transition tissue glutamate and citrate fell by 22 and 45%, respectively, and there were reciprocal decreases in malate and aspartate. the ratio of creatine phosphate/creatine declined by 50% within 30 sec, wi ...1975175415
gastric mucosal blood flow and pepsin secretion in dogs--stimulation by 13-nle-motilin.in response to graded doses of intravenous 13-norleucine-motilin (13-nle-motilin)--a synthetic analogue of motilin and biologically equivalent to the natural polypeptide-, gastric mucosal blood flow (gmbf) in canine vagally denervated fundic pouches was studied using the aminopyrine clearance technique. as 13-nle-motilin did not exert any detectable effect on gastric secretion of hydrogen ions, intraluminal instillation of 160 mm hcl was used to provide a ph gradient allowing aminopyrine to move ...1976175432
[sex hormones and calcitonin secretion].the increase in serum calcitonin during pregnoncy raises the problem of the role of oestrogens in the secretion of calcitonin. the authors show that oestrogen causes, in castrated rats, an increase in calcitonin activity as measured in the plasma by a biological method. this effect of injected oestrogen does not occur if the castrated animal is also submitted to thyroidectomy. the effects of progesterone studied on a small number of cases, seem to be less marked. this report shows that oestrogen ...1975175475
localization of selenium in bacterial cells using tem and energy dispersive x-ray analysis.bacteria isolated from lake sediment samples reduced sodium selenite to elemental selenium. finestructural observations were made on a number of different bacterial species cultured in the presence of sodium selenite. examination of escherichia coli and a pseudomonas species revealed electron-dense deposits of irregular shape, composed of smaller units, within the cytoplasm but not on the cell wall and cell membrane. cells of aeromonas and flavobacterium species exhibited conspicuous intranuclea ...1976175749
[the effect of extracardiac nerves on the intensity of glycogen metabolism in cardiac muscle].the left vagus was cut in rats on the neck; this was followed by a reduction of the glycogen content in the myocardium and by an increase in the intensity of its metabolism (by the glucose-i-c14 incorporation). sympathetic denervation of the heart led to the increase in the glycogen level and a fall of the intensity of its metabolism in the cardiac muscle.1975175866
nicotinamide nucleotide transhydrogenase in entamoeba histolytica, a protozoan lacking mitochondria. 1976175989
letter: radiosensitivity of nad glycohydrolase in the nuclear membrane of fast growing mouse liver. 1975176122
immunofluorescent detection of adenovirus antigen in epidemic keratoconjunctivitis.an immunofluorescent technique was used to demonstrate soluble adenoviral antigens in epithelial cells on conjunctival scrapings of patients with epidemic keratoconjunctivitis (ekc). conjunctival scrapings for immunofluorescence and viral isolation studies were performed on 79 patients suspected of having ekc or other acute follicular or papillary conjunctivitides. of 41 patients with clinical findings consistent with a diagnosis of ekc and three patients with pharyngoconjunctional fever, 43 wer ...1976176130
[inhibition of vitamin d3 action on serum calcium concentration in rats treated with stannous chloride (author's transl)]. 1975176487
[antiviral effects of acridine derivative c 283 in herpes simplex studies]. 1976176541
susceptibility of beta-hemolytic streptococci to 65 antibacterial agents.tests for susceptibility of 29 group a, 4 group c, and 2 group g strains of beta-hemolytic streptococci to 63 antibiotics and to trimethoprim and sulfamethoxazole, singly and combined in a ratio of 1:16, were carried out in vitro. all strains tested were moderately or highly susceptible to all the antibiotics used except those belonging to the aminoglycoside and polymyxin groups. a few were also resistant to the tetracyclines and to sulfamethoxazole alone. comparisons with results obtained in pr ...1976176926
the human tongue during sleep: electromyographic activity of the genioglossus muscle. 1976177304
detection and characterization of differences in plasma corticoid response to treatments.ten experiments involving 3013 observations and 103 animals were studied to characterize variation associated with bovine plasma corticoid concentrations (ng/ml). total corticoids, corticosterone, or cortisol were measured by competitve protein binding assay. animals were noncystic or cystic, and measurements were made to establish basal concentrations or to estimate response to stimulation by adrenocorticotrophic hormone injection. data were analyzed by least squares with the nested model: trea ...1976177471
dopamine synthesis in rat brain striatal synaptosomes. ii. dibutyryl cyclic adenosine 3':5'-monophosphoric acid and 6-methyltetrahydropterine-induced synthesis increases without an increase in endogenous dopamine release.the effects of n6, o2'-dibutyryl cyclic adenosine 3':5'-monophosphoric acid (dibutyryl cyclic amp), dl-6-methyl-5, 6, 7, 8-tetrahydropterine (6-mph4) and tyramine on dopamine synthesis and endogenous dopamine release in rat brain striatal synaptosomes have been examined. dibutyryl cyclic amp (1 mm) produced a 100% increase in dopamine synthesis but had no effect on endogenous dopamine release. veratridine (75 mum) did not further stimulate dibutyryl cyclic amp-treated tissue. 6-mph4 (0.1 mm) als ...1976177758
a comparative morphometric analysis of the effects of thyroxine and acth on the zona fasciculata of rat adrenal cortex.the effects of thyroxine and acth on the ultrastructure of cells of the adrenal zona fasciculata were studied by morphometric analysis and compared by two-way analysis of variance. the results indicate that the effects of thyroxine and acth are different and independent. the statistically significant differences in effect of thyroxine and acth are: thyroxine causes an increase in the volume fraction of mitochondria and a decrease in the volume fraction of endoplasmic reticulum independent of act ...1976178165
effect of ambient temperatures on multiplication of attenuated transmissible gastroenteritis virus in the bodies of newborn piglets.newborn piglets were found to be more resistant to infection with attenuated transmissible gastroenteritis virus when maintained at higher temperatures. this was attributed to a decreased rate of virus propagation and spreading in the bodies of the infected animals. the highest virus levels were detected in the tissues of piglets maintained at 8 to 12 c. in contrast, no virus was recovered from piglets maintained at 35 to 37.5 c. the virus was found only in the lymph nodes and respiratory organs ...1976178601
modified hemolytic plaque technique for the detection of bluetongue virus antibody-forming cells.a hemolytic plaque assay was developed for the detection of antibody-forming cells to bluetongue virus (btv). sheep erythrocytes (srbc), onto which btv had been absorbed, served as the indicator of lysis due to the presence of btv antibody-forming cells. the ratio of btv to srbc was found to be critical for optimum hemolytic plaque formation. for routine use, 50 mul of 12% btv srbc, 0.1 ml of a spleen cell suspension, and 0.5 ml of 0.5% agarose in a balanced salt solution were mixed and plated o ...1976178602
oxidative phosphorylation in micrococcus denitrificans: calculation of the p/o ratio in growing cells.p/o ratios were measured in membrane particles obtained from cells of micrococcus denitrificans, while growing on different carbon sources. the membrane particles obtained from cells growing actively on glucose, succinate, ethanol and propanol as the carbon and energy sources catalyzed oxidative phosphorylation and yielded respective p/o ratios of 1.4, 1.2, 0.8, and 0.5 with nadh, and 0.8, 0.6, 0.6, and 0.5 with succinate as the electron donors. not such a difference in p/o ratio is observed in ...1976179486
studies on the corticotrophin-releasing activity of vasopressin, using acth secretion by cultured rat adenohypophyseal cells.crf activity of synthetic vasopressins and pitressin was studied in an in vitro system of cultured rat adenohypophyseal cells using direct measurement of acth by radioimmunoassay. pitressin (posterior pituitary extract) induced a dose-related secretion of acth whereas synthetic arginine or lysine vasopressin were devoid of crf activity, even with the largest tested dose (4 mug/ml). no potentiation of the crf activity of hypothalamic extract was observed with any vasopressin preparation studied. ...1976179790
daily variation in concentration of plasma corticosteroid in hypophysectomized rats.a daily variation in the concentration of plasma corticosteroid hormone is present in hypophysectomized rats implanted with pellets of adrenocorticotropic hormone (acth) and thyroxine. although acth is necessary to maintain a functional adrenal, and thyroxine is required to permit the expression of the plasma corticosteroid rhythm, a normal daily variation in plasma corticosteroid concentration does not appear to depend on the periodic release of pituitary hormones.1976179796
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