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prevalence and risk factors associated with stis among women initiating contraceptive implants in kingston, jamaica.there is limited information on rates of stis in jamaica due to syndromic management and limited aetiological surveillance. we examined the prevalence of chlamydia trachomatis (ct), neisseria gonorrhoeae (ng) and trichomonas vaginalis (tv) and characteristics associated with stis among sexually active women who participated in a randomised trial of a progestin implant initiation in jamaica (the sino-implant study (sis)).201728476913
antimicrobial susceptibilities of chlamydia trachomatis isolated from the urethra and pharynx of japanese males.sexually transmitted infections due to chlamydia trachomatis (c. trachomatis) are a worldwide public health problem. the aim of this study was to investigate the drug susceptibilities of c. trachomatis strains isolated from the urethra and pharynx of japanese males.201728476331
spatial clustering of high load ocular chlamydia trachomatis infection in trachoma: a cross-sectional population-based study.chlamydia trachomatis (ct) is the most common cause of bacterial sexually transmitted infection and infectious cause of blindness (trachoma) worldwide. understanding the spatial distribution of ct infection may enable us to identify populations at risk and improve our understanding of ct transmission. in this study, we sought to investigate the spatial distribution of ct infection and the clinical features associated with high ct load in trachoma-endemic communities on the bijagós archipelago (g ...201728472466
evaluating the utility of syndromic case management for three sexually transmitted infections in women visiting hospitals in delhi, india.utility of syndromic case management (scm) in women visiting obstetrics & gynecology department needs to be evaluated as it is subjective and imperfect. consequently, antibiotic resistance has accelerated along with increased risk of infection to the partners. to understand the effectiveness and/or inadequacies of scm, 11000 women were recruited and examined by clinicians for infection by chlamydia trachomatis (ct), neisseria gonorrhoeae (ng), trichomonas vaginalis (tv), bacterial vaginosis (bv) ...201728469158
lactobacillus plantarum producing a chlamydia trachomatis antigen induces a specific iga response after mucosal booster immunization.mucosal immunity is important for the protection against a wide variety of pathogens. traditional vaccines administered via parenteral routes induce strong systemic immunity, but they often fail to generate mucosal iga. in contrast, bacteria-based vaccines comprise an appealing strategy for antigen delivery to mucosal sites. vaginal infection with chlamydia trachomatis can develop into upper genital tract infections that can lead to infertility. therefore, the development of an effective vaccine ...201728467432
chlamydia hijacks arf gtpases to coordinate microtubule posttranslational modifications and golgi complex positioning.the intracellular bacterium chlamydia trachomatis develops in a parasitic compartment called the inclusion. posttranslationally modified microtubules encase the inclusion, controlling the positioning of golgi complex fragments around the inclusion. the molecular mechanisms by which chlamydia coopts the host cytoskeleton and the golgi complex to sustain its infectious compartment are unknown. here, using a genetically modified chlamydia strain, we discovered that both posttranslationally modified ...201728465429
the frequency of gonorrheal and chlamydial infections in zanjanian women in 2013-2014.chlamydia trachomatis and neisseria gonorrhoeae are the most prevalent bacterial sexually transmitted diseases in women.201728462398
evaluation of tandem chlamydia trachomatis momp multi-epitopes vaccine in balb/c mice model.chlamydia trachomatis (ct), an obligate intracellular parasite, is the leading cause of bacterial sexually transmitted diseases worldwide. the best solution to control the spread of ct is to develop safe and effective vaccines. however, an effective vaccine has not been developed due to some challenges such as selection of appropriate candidate antigens and an effective delivery system. in our previous study, we have developed a ct vaccine that comprises a multi-epitope peptide of ct major outer ...201728456528
prevalence of human papillomavirus, chlamydia trachomatis, and trichomonas vaginalis infections in amazonian women with normal and abnormal cytology.sexually transmitted infections are an important cause of morbidity among sexually active women worldwide, and have been implicated as cofactors in the pathogenesis of cervical cancer. we investigated the prevalence of human papillomavirus (hpv), chlamydia trachomatis (ct), and trichomonas vaginalis (tv), and accessed the diversity of hpv in women with normal and abnormal cytology in manaus, brazil. we used polymerase chain reaction and hpv genotyping by direct sequencing. the chi-square test wa ...201728453175
authors'reply: concern regarding the alleged spread of hypervirulent lymphogranuloma venereum chlamydia trachomatis strain in europe. 201728449737
concern regarding the alleged spread of hypervirulent lymphogranuloma venereum chlamydia trachomatis strain in europe. 201728449734
patient, staffing and health centre factors associated with annual testing for sexually transmissible infections in remote primary health centres.background: in high-incidence chlamydia trachomatis (ct) and neisseria gonorrhoeae (ng) settings, annual re-testing is an important public health strategy. using baseline laboratory data (2009-10) from a cluster randomised trial in 67 remote aboriginal communities, the extent of re-testing was determined, along with the associated patient, staffing and health centre factors. methods: annual testing was defined as re-testing in 9-15 months (guideline recommendation) and a broader time period of 5 ...201728445684
immunoglobulin-based investigation of spontaneous resolution of chlamydia trachomatis infection.chlamydia trachomatis (ct) elementary body (eb) elisa was used to investigate serum anti-ct igg1 (long-lived response) and igg3 (short-lived response indicating more recent infection) from treatment (enrollment) and 6-month follow-up visits in 77 women previously classified as having spontaneous resolution of chlamydia. 71.4% of women were igg1+igg3+, consistent with more recent chlamydia resolution. 15.6% were igg3- at both visits, suggesting absence of recent chlamydia. using eb elisa, we demo ...201728444306
[persistent, therapy-resistant conjunctivitis: consider infection with chlamydia trachomatis].conjunctivitis is a frequently diagnosed disease, usually caused by a virus. a less well-known cause is a chlamydia infection. this may result in missed diagnoses, delay of treatment and several complications. we present two cases of a persistent, therapy-resistant conjunctivitis in patients who were over 70 years of age. one patient had conjunctival follicles, characteristic of chlamydia conjunctivitis. the polymerase chain reaction tests of conjunctival samples from both patients were positive ...201728443807
proton pump inhibitors are associated with a reduced likelihood for sexually transmitted diseases in women in the emergency department.proton pump inhibitors (ppis) have been shown in cell culture to kill trichomonas vaginalis (tv) at lower half maximal inhibitory concentration values than metronidazole (flagyl), the most common medication used to treat the infection. however, there have been no previous clinical investigations to determine if ppis are associated with reduced risk for tv.201728442805
exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing chlamydia trachomatis pathogenesis.chlamydia trachomatis remains a leading cause of bacterial sexually transmitted infections and preventable blindness worldwide. there are, however, limited in vitro models to study the role of host genetics in the response of macrophages to this obligate human pathogen. here, we describe an approach using macrophages derived from human induced pluripotent stem cells (ipsdms) to study macrophage-chlamydia interactions in vitro. we show that ipsdms support the full infectious life cycle of c. trac ...201728440293
antibiotic therapy for pelvic inflammatory disease.pelvic inflammatory disease (pid) is an infection that affects 4% to 12% of young women, and is one of the most common causes of morbidity in this age group. the main intervention for acute pid is the use of broad-spectrum antibiotics which cover chlamydia trachomatis, neisseria gonorrhoeae, and anaerobic bacteria, administered intravenously, intramuscularly, or orally. in this review, we assessed the optimal treatment regimen for pid.201728436019
cervicovaginal levels of human β-defensin 1, 2, 3, and 4 of reproductive-aged women with chlamydia trachomatis infection.this study included women attending primary health care units in botucatu, são paulo, brazil, to assess the cervicovaginal levels of human β-defensin (hbd) 1, 2, 3, and 4 during chlamydia trachomatis infection.201728430679
a national strategic plan for reducing the burden of sexually transmitted infections in israel by the year 2025.there is on ongoing debate in the literature regarding the real burden of stis (sexually transmitted infections) in western countries and the proper strategies needed to estimate and to prevent them. our purpose is to present an evidence-based national strategic plan for sti prevention in israel through assessing the current burden of illness, leading international preventive strategies, and practical policymaking experience.201728428838
a comprehensive overview of urogenital, anorectal and oropharyngeal neisseria gonorrhoeae testing and diagnoses among different sti care providers: a cross-sectional study.gonorrhoea, caused by neisseria gonorrhoeae (ng), can cause reproductive morbidity, is increasingly becoming resistant to antibiotics and is frequently asymptomatic, which shows the essential role of ng test practice. in this study we wanted to compare ng diagnostic testing procedures between different sti care providers serving a defined geographic dutch region (280,000 inhabitants).201728427377
profile of the triplex assay for detection of chlamydia, gonorrhea and trichomonas using the bd max™ system.chlamydia, gonorrhea and trichomonas are the most common curable sti. improved access to testing could reduce infection rates and prevent sequelae. nucleic acid amplification tests are the recommend class of diagnostic assay for these infections which are often asymptomatic. areas covered: a description of the bd max™ system (max) and the bd max ct/gc/tv assay is provided along with data from a large us clinical trial. the capacity of the system for other tests and for lab developed assays is al ...201728425774
development of a novel rationally designed antibiotic to inhibit a nontraditional bacterial target.the search for new nontraditional targets is a high priority in antibiotic design today. bacterial membrane energetics based on sodium ion circulation offers potential alternative targets. the present work identifies the na(+)-translocating nadh:ubiquinone oxidoreductase (na(+)-nqr), a key respiratory enzyme in many microbial pathogens, as indispensible for the chlamydia trachomatis infectious process. infection by chlamydia trachomatis significantly increased first h(+) and then na(+) levels wi ...201728425301
molecular detection of chlamydia trachomatis and semen quality of sexual partners of infertile women.chlamydia trachomatis is considered as the bacterium that is more sexually transmitted as cause of male urethritis, epididymitis, orchitis and infertility. a total of 116 semen samples of men whose couples are infertile women were analysed. the quality of the semen was measured by standard procedures recommended by who while c. trachomatis was detected by the pcr assay. thirty-seven semen samples were positive for c. trachomatis (31.9%). regarding semen analysis, no different values were observe ...201728421619
conventional versus molecular detection of chlamydia trachomatis and neisseria gonorrhoeae among males in a sexually transmitted infections clinic.chlamydia trachomatis and neisseria gonorrhoeae are important bacterial pathogens of sexually transmitted infections (stis) worldwide. this study sought to compare the analytical sensitivity and specificity of conventional methods against a rapid molecular method in detecting stis caused by these bacteria.201728413202
the case for extragenital screening of chlamydia trachomatis and neisseria gonorrhoeae in the college health setting.although the centers for disease control and prevention does not recommend routine oropharyngeal and anorectal screening for chlamydia trachomatis and neisseria gonorrhoeae in the general population, they do recommend it for men who have sex with men. however, risk-based extragenital screening of men may not have been adopted at all college health centers, and existing research has not focused on the college population.201728407642
dorsal longitudinal foreskin cut is associated with reduced risk of hiv, syphilis and genital herpes in men: a cross-sectional study in papua new guinea.various forms of penile foreskin cutting are practised in papua new guinea. in the context of an ecological association observed between hiv infection and the dorsal longitudinal foreskin cut, we undertook an investigation of this relationship at the individual level.201728406272
dna plasmid vaccine carrying chlamydia trachomatis (ct) major outer membrane and human papillomavirus 16l2 proteins for anti-ct infection.chlamydia trachomatis (ct) is one of the most frequently encountered sexual infection all over the world, yielding tremendous reproductive problems (e.g. infertility and ectopic pregnancy) in the women. this work described the design of a plasmid vaccine that protect mice from ct infection, and reduce productive tract damage by generating effective antibody and cytotoxic t cell immunity. the vaccine, s was composed of momp multi-epitope and hpv16l2 genes carried in pcdna plasmid (i.e. pcdna3.1/m ...201728402260
the netherlands chlamydia cohort study (neccst) protocol to assess the risk of late complications following chlamydia trachomatis infection in women.chlamydia trachomatis (ct), the most common bacterial sexually transmitted infection (sti) among young women, can result in serious sequelae. although the course of infection is often asymptomatic, ct may cause pelvic inflammatory disease (pid), leading to severe complications, such as prolonged time to pregnancy, ectopic pregnancy, and tubal factor subfertility. the risk of and risk factors for complications following ct-infection have not been assessed in a long-term prospective cohort study, ...201728399813
the picasso cohort: baseline characteristics of a cohort of men who have sex with men and male-to-female transgender women at high risk for syphilis infection in lima, peru.men who have sex with men (msm) and male-to-female transgender women (transwomen) are disproportionately at risk of syphilis infection in peru.201728399798
maternal antibodies to chlamydia trachomatis and risk of gastroschisis.gastroschisis, a birth defect of the abdominal wall, is increasing in prevalence. the largest increase in prevalence has been observed among young mothers (<20 years). the prevalence of chlamydia trachomatis (ct) infection is highest among young women and has also been increasing over time. the objective was to investigate the association between immunoglobulin g antibodies to chlamydia trachomatis (ct) (anti-ct) and chlamydial heat shock protein 60 (anti-chp60) during pregnancy, and risk of gas ...201728398639
biochemical and genetic analysis of the chlamydia groel chaperonins.chaperonins are essential for cellular growth under normal and stressful conditions and consequently represent one of the most conserved and ancient protein classes. the paradigm escherichia coli chaperonin, ecgroel, and its cochaperonin, ecgroes, assist in the folding of proteins via an atp-dependent mechanism. in addition to the presence of groel and groes homologs, groel paralogs are found in many bacteria, including pathogens, and have evolved poorly understood species-specific functions. ch ...201728396349
self-collected glans/meatal 'dry' swab specimen and naat technology detects chlamydia trachomatis and neisseria gonorrhoeae - implications for public policy changes.increasing chlamydia trachomatis (ct) rates and ever-present neisseria gonorrhoeae (ng) infections in women have given rise in the past to consideration of male screening programs in order to address the silent male reservoir. non-medical venues (e.g. home collection, restrooms or other private locations) may be viable venues to reach certain populations that in the past have not been accessed. effortlessly collected, non-invasive, self-collected male specimens that are stable and easy to transp ...201728632470
mycoplasma genitalium presence, resistance and epidemiology in greenland.objectives . greenland reports the highest rates of chlamydial infection and gonorrhea in the arctic. our objective was to determine the presence, and describe the basic epidemiology, of mycoplasma genitalium for greenland. study design . cross-sectional study. methods . 314 residents from nuuk and sisimiut, between the ages of 15 and 65 years, participated in "inuulluataarneq" (the greenland sexual health project) between july 2008 and november 2009. participants provided self-collected samples ...201228417753
seroprevalence of antibodies to conserved regions of chlamydia trachomatis heat shock proteins60 and 10 in women in india.persistent, untreated chlamydial infection causes chronic stimulation of the host immune system against immunogenic antigens such as chlamydial heat shock proteins (chsp) 60 and 10. in order to find the seroprevalence of antibodies to chsps, enzyme-linked immunosorbent assay (elisa) is performed using specific peptide sequences to measure antibody response against major outer membrane protein (momp), chsp60 and chsp10 in patient sera. in this study, 255 patients attending the gynaecology out-pat ...200728696885
impact of host genetics on susceptibility to human chlamydia trachomatis disease.evidence that host genetic factors play a major role in susceptibility or resistance to many infectious diseases is increasing, due to major advances in genetic epidemiological methodology. recent human genome mapping information and the identification of a large number of candidate genes provide the tools for such studies. the information obtained is important for understanding the pathogenesis of disease and for the design of preventive and therapeutic strategies. in the study of chlamydia tra ...200228700855
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