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fertility of friesian heifers after luteolysis with a prostaglandin analogue (ici 80996). 19751146149
protein profiles of dense-centered forms of five chlamydial strains of animal origin.purified dense-centered form of 1 bovine strain (lw613) and 3 ovine strains (b577, 034-eye, and 047-eye) of chlamydia psittaci and 1 murine strain of chlamydia trachomatis (mopn) were dissociated in the presence of sodium dodecyl sulfate (sds) and 2-mercaptoethanol. the number of polypeptides detected in the 5 strains varied between 17 and 20, with a molecular weight range of 29,000 to 120,000. two polypeptides predominated and comprised approximately a third of the total protein in each of the ...19751147351
comparative antihypertensive effects and tissue distribution of beta adrenergic blocking drugs.the precise mechanism of the antihypertensive action of beta adrenergic blocking drugs is not known. both peripheral and central sites of action have been proposed. the comparative antihypertensive actions and tissue distribution of propranolol, pindolol and sotalol were investigated in both normotensive sprague-dawley and spontaneously hypertensive rats. from recordings of concurrent changes in blood pressure and heart rate it was observed that oral or subcutaneous administrations of both propr ...19751151751
proceedings: the effects of axotomy and nerve growth factor on the neuronal population of the superior cervical ganglion of the mouse. 19751151884
synthesis and pharmacological properties of 4-piperazino-5-methylthiopyrimidines. selection of new antiemetic agents.we have synthetized a series of 22 new 4-piperazinopyrimidines bearing a methylthio substituent in the 5 position of the pyrimidine ring. these compounds have been obtained by separation of the isomers formed during nucleophilic attack of the corresponding 2,4,6-trichloropyrimidine by amines. pharmacological screening has shown that this chemical series displays a very interesting profile, which includes antiemetic, tranquilizing, analgesic, antiserotonin, and musculotropic-spasmolytic propertie ...19751151967
[relation of changes in water metabolism dynamics in rabbits to the dose of external gamma-radiation]. 19751153725
minocycline in the treatment of nongonococcal urethritis: its effect on chlamydia trachomatis.the effect of minocycline on nongonococcal urethritis (ngu) was investigated, with particular reference to its action against chlamydia trachomatis. preliminary laboratory studies showed that the drug was active against a laboratory chlamydial strain (lb4f) in vitro. a group of 133 men with first attacks of ngu was then treated with minocycline, 100 mg twice daily for 3 weeks. isolates of c trachomatis were obtained from 33 of these men before treatment; all of them gave negative results on cell ...19751158770
a kinetic estimation of base sequence complexity of nuclear poly(a)-containing rna in mouse friend cells.complementary dna (cdna) has been transcribed by viral reverse transcriptase from poly(a)-containing nuclear rna prepared from growing mouse friend cells (clone m2). annealing experiments with this cdna have demonstrated that a large proportion of the poly(a) tracts in m2 cell nuclear rna are adjacent to rna sequences which are transcribed from nonrepetitive dna in the mouse genome. the kinetics of hybridization of cdna to template rna indicate that nuclear poly(a)-containing rna consists of at ...19751168544
estimation of plasma testosterone without extraction and chromatography.a new radioimmunoassay for plasma testosterone in human blood plasma is described. the assay is performed directly upon the plasma without extraction and purification of the testosterone. antibodies to testosterone-7alpha-carboxyethyl thioether-bovine serum albumin are used and data concerning the specificity of these antibodies are given.19751168552
hepatitis b antigen in clinical chemistry control sera. 19751168553
discontinuous dna replication in mouse p-815 cells.the length of newly synthesized dna strands from mouse p-815 cells was analyzed after denaturation both by electrophoresis and by sedimentation in alkaline sucrose gradients. [3-h]-thymidine pulses of 2-8 min at 37 degrees c predominantly label molecules of 20-60 s. with 30-s pulses at 25 degrees c, all the [3-h]thymidine appears in short dna strands of 50-200 nucleotides. thus, dna strand elongation occurs discontinuously via okazaki fragments at both the 5' end and the 3' end. in dodecylsulfat ...19751168572
the synthesis of ribosomal protein and ribosomal rna in a rat-mouse hybrid cell line. 19751168581
dipetalonema viteae: primary, secondary and tertiary infections in hamsters. 19751168583
dirofilaria immitis: ultrastructural aspects of oocyte development and zygote formation. 19751168584
[work hygiene in the manufacture of amino-tobias acid from the viewpoint of the carcinogenic danger for workers]. 19751168606
effect of testosterone and estradiol-17beta on synthesis of dna, rna and protein in human breast in organ culture.effects of testosterone (t) and estradiol-17beta (e-2) on the synthesis of dna, rna and protein were studied in explants of the following types of malignant and non-malignant human female breast grown in organ culture: cystic mastitis (7 cases), fibroadenoma (8), carcinoma (17) and uninvolved tissue from cancer-bearing breast (8). in cultures of systic mastitis t uniformly inhibited the incorporation of thymidine-3h into dna, uridine-3h into rna and l-amino acids-14c (aa-14c) into protein. e-2 i ...19751168626
dynamics of the delta-5-3beta-hydroxysteroid dehydrogenase activity in rat follicular granulosa cells during proestrus. 19751169104
incorporation of n-acetylglucosamine into the slime sheath of the cellular slime mould dictyostelium discoideum. 19751169163
the effects of pent-4-enoate and methylenecyclopropylacetate on some enzymes of beta-oxidation in extracts of liver mitochondria. 19751169177
time-dependent changes in commissural field potentials in the dentate gyrus following lesions of the entorhinal cortex in adult rats.previous neuroanatomical work has shown that lesions of the entorhinal cortex in adult rats cause the commissural projections to spread from their normally restricted locus in the inner molecular layer approximately 40-50 mum into the outer molecular layer (that is, into the zone deafferented by the lesion). in the present study we measured the effects of the entorhinal lesion on the distribution of short-latency potentials elicited by commissural stimulation in the molecular layer. studies with ...19751175043
endogenous prostaglandin release contributes directly to coronary artery tone.an in vitro coronary artery preparation of beef heart was found to synthesize and release continuously large amounts of a prostaglandin of the e type. inhibition of prostaglandin synthesis with aspirin, indomethacin, or eicosa-5,8,11,14-tetraynoic acid induced a sustained contraction of the coronary artery, and pretreatment with indomethacin diminished markedly the output of prostaglandin into the bathing medium. it appears that prostaglandin e1, generated from within the vessel wall itself, may ...19751175084
new drug evaluation using exercise-induced bronchospasm.exercise-induced asthma was used to demonstrate that a xanthone, a new orally active cromolyn-like drug, has significant activity in man. the effect of a single oral dose of 8 mg/kg was studied in a double-blind corss-over fashion at two and five hours after administration, with significant inhibition of post-exercise bronchospasm being seen at five hours. further study seems indicated to determine optimal dosage and clinical effectiveness.19751187285
alkali burns of the rabbit cornea. i. a histochemical study of beta-glucuronidase, beta-galactosidase and n-acetyl-beta-d-glucosaminidase.in alkali burned rabbit corneas activities of beta-glucuronidase, n-acetyl-beta-d-glucosaminidase and acid beta-galactosidase were studied histochemically in various time intervals after the traumatization. the technic with semipermeable membranes was employed. within four days after the injury enzyme activities in the traumatized area were almost lacking. the corresponding activities in the unaffected part of the cornea were within the norm. on the 7th day enzyme activities were on an increase ...19751194085
aflatoxin residues in tissues of growing swine: effect of separate and mixed feeding of protein and protein-free portions of the diet. 19751194119
some factors affecting tissue po2 in the carotid body.in the carotid body (cb) of the anesthetized cat tissue po2 (pto2) measured with a micro o2 electrode averaged about 65 mmhg at normal arterial pressure (mean = 96 mmhg). pto2 correlated significantly with the hematocrit of the arterial blood but not with % saturation. when arterial pressure was reduced (mean = 58 mmhg) by bleeding pto2 fell significantly. phentolamine injection (1 mg/kg iv) at the reduced pressure caused pto2 to rise significantly. at normal arterial pressure blowing moistened ...19751194147
dc temperature-regulating device for anesthetized experimental animals.a temperature-regulating device for anesthetized experimental animals is presented. the rectal temperature of the animal is measured with a thermistor and this variable controls via nonlinear amplification the power fed to the heating pad on which the animal is placed. rectal temperature variations of not more than +/- 0.1 degrees c are reached after 30 min of operation.19751194161
purification properties and subunit composition of pig heart lipoate acetyltransferase.lipoate acetyltransferase [acetyl-coa: dihydrolipoate s-acetyl-transferase, ec 2.3.1.12], the core enzyme of the pyruvate dehydrogenase complex, has been highly purified by gel chromatography on sepharose 6b and sucrose density gradient centrifugation in the presence of potassium iodide. the native enzyme has a sedimentation coefficient (s020,w) of 26.7s and a diffusion coefficient (d020,w) of 1.25 x 10(-7) cm2.-sec-1. the weight-average molecular weight was estimated to be 1.8 million from the ...19751194249
effect of glucocorticoids on the glucose transport system of isolated fat cells.glucocorticoids inhibit glucose utilization by fat cells. the possibility that this effect results from altered glucose transport was investigated using an oil-centrifugation technique which allows a rapid (within 45 s) estimation of glucose or 3-o-methylglucose uptake by isolated fat cells. at high concentration (greater than 25 mum), dexamethasone inhibited glucose uptake within 1 min of its addition to fat cells. efflux of 3-o-methylglucose was also impaired by 0.1 mm dexamethasone. however, ...19751194258
growth limitation of 3t3 mouse fibroblasts by available growth surface area and medium components.studies with untransformed fibroblasts demonstrate that growth of these cells in culture can be limited by the availability of both growth surface and medium components. experiments using cells grown on coverslips, in which the only variable was available growth surface, indicate that when the medium to cell ratio is high, surface area is the principal factor limiting growth. at low medium to cell ratios, however, growth of cells is predominantly limited by medium components. the final number of ...19751194367
growth enhancement of myogenic tumor cells by conditioned medium from embryo fibroblasts.growth medium was conditioned by incubation on mouse embryo cells in vitro. supplementation of agar suspension cultures with conditioned medium from primary cells, but not from established lines, readily enhanced colony development by mouse tumor cells. only cells with the properties of myoblasts responded to conditioned medium. other fibroblastoid cells and virus-transformed cell lines were not affected. myogenic cells in agar cultures grew in the presence of conditioned medium but did not diff ...19751194369
runway performance of rats for brain-stimulation or food reward: effects of hunger and priming.in a runway paradigm, pretrial electric stimulation of the brain (esb), food deprivation, and to a lesser extent water deprivation increased the running speed of rats to an esb reward. the trial-by-trail course of the change in running speed after the manipulation of food deprivation resembled the steplike performance effect seen when pretrial priming esb is changed rather than the incremental learning effect seen when the response contingent esb is changed. in a second experiment, pretrial esb ...19751194461
effect of calories on appetite for palatable food in obese and nonobese humans.palatable food stimuli were presented to 11 obese and 11 nonobese male human subjects (in three experiments) 1 hr after ingestion of 900-calorie liquid lunches and (on separate days) indentically tasting 450-calorie liquid lunches of equal volume. salivary responses to the presentation of the stimuli (i.e., appetite) by the nonobese were inhibited by the high-calorie meal, but those by the obses were less inhibited. hunger ratings were unaffected by calories in either group. food stimuli were ra ...19751194463
interaural attenuation versus frequency for guinea pig and chinchilla cm response. 19751194558
biotin content of feedstuffs. 19751194583
isolation and chemical characterization of a granuloma glycoprotein that inhibits macrophage phagocytosis.a saline soluble glycoprotein isolated from 14- and 42-day polyvinyl sponge granulomas was shown to depress in vitro phagocytosis by peritoneal macrophages. the glycoprotein had no effect on polymorphonuclear phagocytosis. chemical and physical characterization of the inhibitor protein obtained from mature (42-day) granulomas developed in guinea pigs indicated that the protein had a molecular weight of 48,500 and an isoelectric point of 5.3. it was homogeneous when examined in three polyacrylami ...19751194750
relative importance of the two major pathways for the conversion of cysteine to glucose in the perfused rat liver.the effects of dietary treatments and substrate availability on the rate of gluconeogenesis from l-cysteine has been investigated in the perfused rat liver. at an optimal concentration (10 mm) of [u-14c]cysteine, after 40 minutes, 3.9% of the label appeared in glucose. this corresponded to 90% of the net glucose coming from cysteine. cysteine was then shown to be converted to glucose at a physiological concentration of substrate (0.1 mm) as well as at the optimal concentration. after 40 minutes ...19751195010
zinc deficiency during the latter third of pregnancy: effects on fetal rat brain, liver, and placenta.the effects of zinc deficiency during the last third of gestation on the growth and development of the fetal rat at term were investigated. zinc deficiency resulted in anorexia and weight loss of the pregnant dams. fetuses from such dams displayed intrauterine growth retardation when compared with fetuses from pair-fed or ad libitum-fed controls given adequate zinc. although the brains of the zinc-deficient fetuses were smaller than those of the controls, the brain was relatively spared while th ...19751195011
comparative responses of radioattenuated trypanosoma brucei and t. congolense in rats. 19751195068
enterohepatic circulation of tetracycline in rats.the absorption of tetracycline hydrochloride excreted in the bile of rats was evaluated using the insitu intestinal preparation. for comparative purposes, the absorption of the drug from an aqueous solution having the same ph as that of the bile was also determined. after 4 hr, the amounts of tetracycline absorbed from the bile and aqueous solutions were 72.92 and 77.34%, respectively. there was no significant difference in the amount of drug accumulated in the gut tissue. the disappearance of t ...19751195117
bioavailability analysis of chlorpromazine in humans from pupilometric data.results of studying the time variation of the miotic response intensity for periods of 6 to 8 hours after dosing in up to 16 normal human subjects who received various oral liquid and intravenous doses of chlorpromazine are reported. relative to oral liquid doses of chlorpromazine syrup, intravenous doses of the drug slowly infused over a consistent time interval of 30 minutes are approximately 11 times as potent in eliciting miotic response activity. miotic activity was found to be quite dose s ...19751195127
ethanol induced slowing of human reaction time and speed of voluntary movement.this study tested the hypothesis that a cns depressant (ethanol) would affect self-initiated psychomotor movement speed as much as the speed of an homologous movement made in response to an external stimulus. four normal ss (three male, one female, aged between 33-45 years) provided well-practiced measures of reaction time and a simple homologous traverse movement (a) in response to a signal from the e and (b) initiated at the s's own discretion. performance by each s under ethanol conditions (b ...19751195146
effect of underfeeding, hemigonadectomy, sex and cyproterone acetate on serum fsh levels in immature rats. 19751195251
haemoglobin types in african cattle.the migration of domesticated animals in africa is of particular interest to the anthropologist and ethnologist in that it may provide valuable information concerning the migration of human tribes that accompanied these animals. haemoglobin c is only found to be present in indigenous breeds of african cattle and can therefore be used as one of the best genetic markers of these animals. haemoglobin b has been established in many breeds in africa and india. it seems that the further away the anima ...19751195269
standard serum chemical and haematological values in the chacma baboon (papio ursinus).blood chemical and haematological determinations were carried out on 64 baboons. the blood chemical and haematological values determined were found to be in general agreement with the values for man and other primate species. some blood constituents however, did show noteworthy differences. marked sex differences were demonstrated in some blood chemical and haematological parameters.19751195270
relationships of immature dermacentor variabilis (say) (acari: ixodidae) with the white-footed mouse, peromyscus leucopus, in southwestern wisconsin. 19751195285
experimentally transmitted marble spleen disease in pen-raised wild turkeys.pen-raised north american wild turkeys (meleagris gallopavo l.) were experimentally infected with marble spleen disease (msd) to determine their susceptibility to this disease. gross and microscopic lesions were consistent with experimental msd in pheasants and domestic turkeys: an enlarged mottled spleen, intranuclear inclusion bodies, and absence of pulmonary edema and hemorrhage. detectable levels of viral antigen were not demonstrable in sera of turkeys using the agar gell precipitin test.19751195488
fish furunculosis caused by aeromonas salmonicida var. achromogenes.an epizootic of sub-acute furunculosis caused by an acromogenic variety of aeromonas salmonicida is described. bacteriologic, serologic and virulence characteristics of the isolate are presented.19751195489
public health and the urban gray squirrel: mycology.from 180 gray squirrels (sciurus c. carolinesis), 942 isolates of fungi representing 19 genera were recovered upon culture of hair-skin scrapings and toenails. of the isolates, 170 represented known human pathogens and 142, squirrel pathogens. a human infection of trichophyton mentagrophytes was derived from handling the squirrels. skin lesions of seven squirrels were attributable to t. mentagrophytes and mucor sp.19751195491
experimental infection of white-tailed deer with rinderpest virus.white-tailed deer (odocoileus virginianus) succumbed to experimental infection with virulent rinderpest (rp) virus that was also lethal to cattle and goats. the deer developed clinical signs typical of rp and died 5 and 6 days post-inoculation. infection was confirmed by recovery of virus from blood before death, from lymph node tissue after necropsy, and demonstration of specific complement fixing antigen in those tissues. electron micrographs of infected vero cell cultures revealed extracellul ...19751195493
[studies on no effect dose of tobramycin and its recovery test in rats (author's transl)]. 19751195514
the inhibitory effect of manganese ion on the pancreozymin-induced amylase release in the perfused rat pancreas. 19751195521
studies on helminth parasites of rats in hokkaido. 19751195523
greyhound injuries. 19751195674
surreptitious laxative ingestion. delayed recognition of a serious condition: a case report.a 46-year-old man with chronic diarrhea underwent exhaustive investigations, including laparotomy, but a definitive diagnosis could not be made. it was not until a colonoscopic biopsy demonstrated the pigment of melanosis coli that the surreptitious use of laxatives was considered seriously. this diagnosis was confirmed by simple chemical tests that demonstrated phenolphthalein in the feces and urine.19751195781
hydroxyproline and hydroxylysine in different tissues of human embryos.the collagen content in various tissues of human embryos was studied at four different steps of the maturation process. the umbilical cord of a 16-17 week old embryo was found to be active in collagen biosynthesis, tibia, articular cartilage and skin showed of a peak of total hydroxyproline in the 16-17th week, decreasing later on, while the hydroxyproline decreased in umbilical cord from the 15-16th week to the 24th week. hydroxylysine followed the hydroxyproline changes in articular cartilage ...19751195787
measurement of urinary bladder emptying using electrical impedance. 19751195824
a system for biofeedback conditioning of electroencephalographic activity. 19751195859
identification of opiate receptor binding in intact animals. 19751195983
blood-brain barrier to 6-hydroxydopamine: uptake by heart and brain. 19751195998
editorial: teaching human sexuality. 19751196196
[long-term results of uretero-ileoplasty. experimental research in 8 dogs]. 19751196268
[method for the immediate measurement of myocardial pressure velocity relationships in situ].a method for instantaneous measurements and representations of myocardial pressure-velocity relations permitting the analysis of various contractility parameters is described. basing on a modified two-element model of cardiac muscle the measurement of the relative shortening velocity vce = dp/dt(p) of the contractile elements is carried out by a special analog computer, which calculates the quotient (dp/dt) to the simultaneous left ventricular pressure p. electronic differentiation of the logari ...19751199597
chlamydial infection in women with cervical dysplasia.the prevalence of antibodies to chlamydiae, particularly to tric (trachoma-inclusion conjunctivitis) agents, was studied in women with cervical dysplasia and in women attending selected clinics (obstetrics, cancer-screening, and gynecology). in addition, attempts were made to isolate tric agents and herpesviruses from the cervices of these women. tric agent recovery rates 4.1 per cent for women with dysplasia, 5.4 per cent for pregnant women, 7.8 per cent in the women's clinic, and 0.8 per cent ...19751200069
comparative study of the smooth muscle contractor activity of airborne dusts and of dustiness in cotton, flax, and jute mills.a bioassay technique using isolated guinea-pig ileum was employed to compare the smooth muscle contractor activity of various dusts from mills in which the prevalence of byssinosis was known. the activity of dust from a mill spinning a coarse grade of cotton was several times greater than that in dust from a mill processing a fine grade of cotton. there was a similar order in the difference of the prevalence of byssinosis in these mills. however, the activities of fine cotton, flax, and jute dus ...19751201255
trachoma in the sudan. a laboratory study.out of 46 patients in the sudan who had been diagnosed clinically as having trachoma 25 strains of the trachoma agent were isolated. bacterial contamination was easily controlled by streptomycin and vancomycin. on repeated passaging, chick embryos lost their susceptibility to the trachoma agent during the summer.19751203228
chlamydial eye disease.in the united states, chlamydial (tric) agents cause a small but important segment of infectious ocular disease. elsewhere in the world, trachoma still represents the single greatest cause of blindness. the description of these diseases in this chapter is a brief introduction to a subject about which volumes have been and will continue to be written. barring unforeseen developments, these agents will continue to plague humankind beyond the end of the twentieth century.19751225860
[influence of endogenous factors on the ash, calcium, magnesium, potassium, sodium, phosphorus, zinc, iron, copper and manganese contents in the bristles of pigs. 3. influence of time of cutting on the mineral composition of the hair (boar bristles)].the ash content and the content of ca, mg, k, and na in the bristles of pigs is influenced by the age of the animal and by the season of the year. the peak concentrations of ash, ca and mg in the bristles of eight boars (cut every month) were found in june, shortly before the change in hair coat. (p less than 0.05-0.001). the concentrations of k and na in the bristles deviated functionally from the change in the hair coat. in the first half of the year the bristles of the boars contained signifi ...19751233935
laboratory procedures for the isolation of chlamydia trachomatis from the human genital tract.the technique of isolating chlamydia trachomatis from the human gential tract by centrifuging clinical specimens on to cell monolayers with subsequent incubation has been improved and simplified. gentamicin in the media was found to be superior to streptomycin in reducing bacterial contamination of specimens. the infectivity of chlamydial suspensions of laboratory cultured material was significantly reduced by storage at +4 degrees c for more than 48 hours, and by immediate freezing to -70 degre ...19751236632
numerical analysis and computerized identification of the yeast genera candida and torulopsis.numerical analysis of the published standard descriptions of 104 species of candida and 48 species of torulopsis suggested that the number of species should be reduced to 78 and 33 respectively. four examples are noted of closely matched species differing in ability to assimilate nitrate; these species may be combined as nitrate-variable species. although the ability to form pseudomycelium is the only important difference between the genera, only three examples were noted of candida and torulops ...19751236931
comparative infectivity of trachoma organisms in hela 229 cells and egg cultures.thirty-two trachoma strains were simultaneously titrated in the yolk sac of embryonated chicken eggs and in hela 229 cells pretreated with diethylaminoethyl-dextran to determine the relative sensitivity of the two culture systems for detection of the infection. the strains tested were both yolk sac- and hela cell-established isolates from the eye and the genital tract. the study showed that the cell culture was of equal or greater sensitivity than yolk sac culture and that ocular and genital iso ...19751238370
some metabolic and biochemical characteristics of representative microbial isolates from vacuum-packaged beef. 19751239440
cd spectral comparison of porcine proinsulin c-peptide and several fragments of its sequence. 19751240088
studies of trachoma in families on taiwan.this study was undertaken to clarify the natural history and pathogenesis of trachoma. a group of families who live in a formerly trachoma hyperendemic area of southern taiwan were placed under continuous surveillance. the development in recent years of the micro immunofluorescence test for trachoma antibody, along with improved cell culture isolation methods, have allowed this surveillance to include repeated effective laboratory studies in addition to clinical observations. after four years' s ...19751243110
trachoma organisms: technical advances in laboratory diagnosis.new knowledge of the microbiology and immunology of chlamydia is reviewed. new serological and isolation methods for diagnosis of trachoma infection are described. results of studies of ocular and genital trachoma infection utilizing these new techniques are presented.19751243119
the effects of cocaine and diphenhydramine upon the reactivity of rat vas deferens to supramaximal doses of noradrenaline and of other agonists: the mode of action of cocaine.the effects of cocaine on responses to supramaximal concentrations of agonists have been studied in preparations of rat vas deferens. cocaine 10 mum decreased the mean time to peak and increased the mean magnitude of responses to noradrenaline but not to supramaximal field stimulation of sympathetic fibres, to high potassium or to methoxamine. diphenydramine 10 mum affected responses to noradrenaline similarly. it is proposed that the prejunctional action of cocaine and of diphenhydramine to red ...19761248509
the nucleoli of cultured human lymphocytes. i. nucleolar morphology in relation to transformation and the dna cycle. 19761248517
effects of deafferentation on the development of the isthmo-optic nucleus in the duck (anas platyrhynchos). 19761248537
fluorosis in black-tailed deer.marked dental disfigurement and abnormal tooth wear patterns were observed in black-tailed deer (odocoileus hemionus columbianus) taken from an area near an industrial fluoride source in northwestern washington. fluoride levels in the bones of these deer were from 10 to 35 times higher than levels in the bones of normal animals. these levels are similar to those associated with fluorosis of cattle.19761255910
the immune response of rabbits to 3 strains of mycoplasma agalactiae var. bovis isolated from mastitic bovine udders.rabbits were given 3 serologically-related trains of mycoplasma isolated from mastitic bovine udders. growth inhibiting antibodies were not found. high-titered sera from each rabbit immunized with each strain developed at least 4 precipitin lines to each organism and at least one line of identity was demonstrated between the organisms. significant indirect hemagglutination titers were found in all rabbits in 1 week, with titers reaching 1.0 x 10(5) to 3.3 x 10(5) in 4 to 6 weeks but despite cont ...19761261267
the detection of antibodies in human and animal filariases by counterimmunoelectrophoresis with dirofilaria immitis antigens.counterimmunoelectrophoresis revealed the presence of precipitin antibody in all of 6 dogs and the 1 cat infected with dirofilaria immitis and in the serum of 17 of 24 individuals living in a setting of hyperendemic subperiodic bancroftian filariasis. antigens used in the test were prepared from microfilariae and adult male d. immitis. some humans and animals had antibodies to both antigens while others had antibodies against microfilariae or adult worms only. the presence of soluble circulating ...19761262695
attenuated, streptomycin-dependent salmonella typhi oral vaccine: potential deleterious effects of lyophilization.four studies were done with streptomycin-dependent salmonella typhi as an oral, attenuated vaccine. studies 1 and 3 employed freshly harvested vaccine, whereas studies 2 and 4 involved lyophilized vaccine. five to eight doses (3 x 10(10)-10(11) organisms/dose) were given; oral streptomycin (1.0 g) was administered concomitantly in studies 2 and 3, with only two of the doses of vaccine in study 1, and was not given in study 4. no adverse reactions were encountered in 179 vaccinated men, and 94% o ...19761262709
activity-related increases of glucose utilization associated with reduced incorporation of glucose into its derivatives. 19761268751
severe endemic trachoma in tunisia.in two villages in southern tunisia where trachoma was endemic 7 per cent and 14 per cent of adults respectively had visual acuity of 20/400 or less. in both villages active trachoma affected most children under the age of two, reached a peak in two- to five-year-olds, then declined to age 15. the chronic inflammatory disease in childhood appeared to produce irreversible scarring of the eyelids, and loss of vision occurred in adult life due to corneal scarring caused by inturned eye lashes and l ...19761276112
the characterization of nonbacterial prostatitis: search for an etiology.nonbacterial prostatitis is often difficult to differentiate from other prostatic complaints and remains a vaguely characterized syndrome. prostatic fluid inflammatory cells and elevated immunoglobulins raise the suspicion that this syndrome is caused by some undetected infection. prostatic fluid antibodies against chlamydia trachomatis, ureaplasma urealyticum, staphylococcus, staphylococcus faecalis, bacteroides fragilis and clostridium perfringens were measured in men with nonbacterial and bac ...19921279213
azithromycin-induced block of elementary body formation in chlamydia trachomatis.the mechanism of action of azithromycin on the murine strain of chlamydia trachomatis grown in tissue culture epithelial cells is addressed. azithromycin at a concentration of 100 ng/ml inhibits chlamydial growth in tissue culture, a value that agrees well with prior in vitro data from human strains of c. trachomatis grown in tissue culture. by morphological criteria, the block to chlamydial growth appears to occur early in its life cycle. azithromycin is not directly toxic to chlamydial element ...19921280057
inhibitory effects of pectic substances on activated hyaluronidase and histamine release from mast cells.in this paper, we report the effect of pectic substances and d-galacturonic acid, the main constituent of pectic substances, on activated hyaluronidase and histamine release from mast cells. although d-galacturonic acid itself showed no inhibition, ic50 values of hyaluronidase inhibition were correlated with the d-galacturonic-acid content of pectic substances. it was thought that the polymerization of d-galacturonic acid was necessary for inhibition of activated hyaluronidase. this type of inhi ...19921280162
melioidosis: when in doubt leave the quinolone alone! 19921280318
azithromycin. a review of its antimicrobial activity, pharmacokinetic properties and clinical efficacy.azithromycin is an acid stable orally administered macrolide antimicrobial drug, structurally related to erythromycin, with a similar spectrum of antimicrobial activity. azithromycin is marginally less active than erythromycin in vitro against gram-positive organisms, although this is of doubtful clinical significance as susceptibility concentrations fall within the range of achievable tissue azithromycin concentrations. in contrast, azithromycin appears to be more active than erythromycin again ...19921280567
infection with a plasmid-free variant chlamydia related to chlamydia trachomatis identified by using multiple assays for nucleic acid detection.clinical samples in transport media from 40 patients exhibiting pathologies potentially caused by chlamydia trachomatis infection were analyzed for chlamydial nucleic acid, and the results were compared with those of culture. chlamydial culture was performed by a shell vial centrifugation method with hela 229 host cells. polymerase chain reaction (pcr) assays were used to detect either regions on a 7.5-kb plasmid characteristic of c. trachomatis (plasmid-pcr) or a segment of the 16s rrna genes ( ...19921280642
convergent and overlapping transcripts of the chlamydia trachomatis 7.5-kb plasmid.transcription of the 7.5-kb cryptic plasmid of chlamydia trachomatis serovar l2 was investigated. faint, diffuse transcripts of about 1.6 and 2.2 kb and intense short transcripts of about 250 and 430 bases were identified by northern blot analysis. the short transcripts were found to have a common 5' end corresponding to bp 501 relative to the unique bamhi site of the plasmid and to terminate at different downstream sites. putative promoter sequences of ttgcca and tatatt, which closely resemble ...19921281330
evidence for a role of the neuropeptide galanin in spatial learning.the neuropeptide galanin coexists with acetylcholine (ach) in the basal forebrain cholinergic neurons and modulates cholinergic activity in the forebrain. the cholinergic forebrain neurons appear to play a significant role in learning and memory, as suggested by a severe loss of these neurons in alzheimer's disease. the involvement of endogenous galanin in learning is demonstrated here by the use of the recently synthesized high-affinity galanin antagonist m35 [galanin(1-13)-bradykinin(2-9) amid ...19921281521
mutagenicity testing of imidazole and related compounds.ames tests have been performed with imidazole and its principal metabolites, hydantoin and hydantoic acid. n-acetyl-imidazole, a potential metabolite resulting from the action of intestinal bacteria, and histamine, a structurally related compound which is widely distributed in mammalian tissues, have also been tested. imidazole and histamine were also tested in the uds assay in primary rat hepatocytes, while imidazole alone was tested in the m2-c3h mouse fibroblast malignant transformation assay ...19921282214
binding of chlamydia trachomatis serovar l2 to collagen types i and iv, fibronectin, heparan sulphate, laminin and vitronectin.chlamydia trachomatis serovar l2 elementary bodies were tested for binding to 125i-labelled components of the extracellular matrix. c. trachomatis bound high levels of collagen type i and heparan sulphate, whereas the binding to collagen type iv, fibronectin, laminin and vitronectin was substantially less. preliminary characterization showed that chlamydial surface proteins are essential for binding to occur. our results suggest that a selective affinity for c. trachomatis to a limited number of ...19921283091
sexually transmitted diseases in england and wales: 1981-1990.data provided by genito-urinary medicine clinics, microbiology laboratories and other reports reveal a consistent picture of the epidemiology of sexually transmitted diseases in england and wales during the 1980s. the number of new cases increased by 21% between 1981 and 1990; most of this increase being due to genital herpes, genital warts and 'non-specific genital infection' (including that due to chlamydia trachomatis). the increase in attendance rates for new cases was much higher for women ...19921285223
prevalence of urogenital chlamydia trachomatis infection in el salvador. ii. gynaecology outpatients.the prevalence of urogenital infection caused by chlamydia trachomatis was examined in 100 non-pregnant women with cervicitis, and 100 healthy women, in san salvador city, el salvador. pharmacia chlamydia eia test was used for the detection of chlamydial antigen in urethral and cervical specimens from all the women. direct immunofluorescence was used for confirmative tests on the eia positive and the negative gray zone samples. c. trachomatis antigen was detected in 28% of the women with cervici ...19921286120
the role of the laboratory in a chlamydia control programme in a developing country.the laboratory components of a chlamydia trachomatis disease control programme for a developing country are reviewed. early diagnosis of chlamydial infections is the most cost effective means of preventing the long term sequelae of trachoma, pelvic inflammatory disease, ectopic pregnancy and infertility, which are now a major public health burden to the health care system in developing countries. public health strategies are required to establish both a co-ordinated limited system of laboratory ...19921286634
increased rate of survival in streptococcus pneumoniae-infected rats treated with the new immunomodulator pidotimod.wistar rats infected with streptococcus pneumoniae (type iii atcc) rapidly develop an acute form of experimental lobar pneumonia (elp) with death of 80-90% of the animals by 6 days after the infection. prophylactic treatment of these animals with the novel immunomodulator pidotimod, at the dose of 25 mg/kg bw, significantly increased their rate of survival as compared to the control group (50 vs. 90% respectively). recovery from the infection appeared definitive since all the pidotimod-treated s ...19921287821
chloroquine-resistant plasmodium falciparum isolates from the sudan lack two mutations in the pfmdr1 gene thought to be associated with chloroquine resistance.isolates of plasmodium falciparum from 3 areas of the sudan were recovered from cryopreservation in london and their chloroquine sensitivity was determined in vitro. chloroquine resistance was detected in 6/6 isolates from khartoum, 1/4 from sennar and 3/3 from gadarif, indicating that resistance is spreading. all the isolates were sensitive to mefloquine. studies using blood spots on glass fibre discs and the polymerase chain reaction did not detect two mutations in the pfmdr1 gene, thought to ...19921287907
chlamydial infections in selected populations in jamaica.the importance of chlamydia trachomatis as a cause of genital tract infection in caribbean countries is largely unknown. two hundred and sixteen cervical and urethral specimens were collected from patients with cervicitis and urethritis attending a sexually transmitted diseases (std) clinic, a gynaecology clinic and a family planning clinic in kingston. specimens were tested for chlamydiae by direct immunofluorescence and cell culture methods. they were also investigated for n. gonorrhoeae infec ...19921290231
[uses of vaginal ph measurement for prevention of premature labor. results of a prospective study].the influence of the microflora of the vagina and cervix has been undervalued for the induction of premature birth. examination of the microbiological problem by determination of the vaginal ph in combination with the microflora (chlamydia trachomatis, mycoplasma hominis, ureaplasma urealyticum). report of the outcome of 161 prospective, ad the beginning normal pregnancies in comparison of 200 primary hospitalized pregnancies with symptoms of imminent premature birth. conclusion: the vaginal ph ...19921290278
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