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fifteen-month follow-up study of women infected with chlamydia trachomatis. 1979758599
the prevention of blindness from trachoma. 1975775692
inclusion blennorrhea: a case report.the case described here represents the first laboratory-confirmed case of inclusion blennorrhea at the mayo clinic since laboratory isolation of chlamydia trachomatis was instituted in 1974. treatment with a sulfonamide preparation proved effective. further aspects of the diagnosis and treatment of inclusion blennorrhea are discussed.1976785121
genital chlamydial infections.the isolation of chlamydial trachomatis in sera of patients with gon ococcal urethritis (gu), non-gonococcal urethritis (ngu), post-gonococca l urethritis (pgu) and trachomainclusion conjunctivitis (tric) is discussed. chlamydiae were isolated in 40% of men with ngu, 20-30% with gu and 0-7% of men with symptomatic or microscopic evidence of urethritis. the rates of isolation of chlamydiae in ngu patients were significantly higher than in controls (p less than .001). the sexual tr ansmitabilit ...1976775980
[ultrastructural study of the trachoma infected conjunctiva]. 1975781768
non-specific urethritis. a placebo-controlled trial of minocycline in conjunction with laboratory investigations.the results of a double-blind therapeutic trial on 81 men suffering from non-specific urethritis (nsu) show that minocycline was more effective than a placebo. before treatment chlamydia trachomatis was isolated from 31 per cent. of the men, ureaplasmas from 58 per cent., and mycoplasma hominis from 7-5 per cent. there is evidence that chlamydiae are a cause of urethritis. however, after minocycline therapy improvement in the clinical response of patients from whom only ureaplasmas were isolated ...1976786440
comparative susceptibility of eleven mammalian cell lines to infection with trachoma organisms.eleven mammalian cell lines, hela 229, hela m, hep-2, ft, bhk-21, vero, mk-2, mpk, l-wo5a2, mccoy, and l-929, were tested for their susceptibility to infection with trachoma strains tw-3 (type c, ocular origin) and uw-5 (type e, genital origin). all the cell layers were pretreated with diethylaminoethyl-dextran before inoculation of the organisms, and the inocula were centrifuged onto the cell layers. hela 229 was found to be the most sensitive to infection as determined by inclusion counts. the ...1975809479
hemolysis-in-gel test for demonstration of chlamydia antibodies.sheep erythrocytes were coated with antigens of a strain of chlamydia trachomatis serotype d. chlamydial antibodies in sera from patients with salpingitis or pneumonia were demonstrated by passive hemolysis in agarose gel.1976791967
simplified serological test for antibodies to chlamydia trachomatis.three-hundred sixty sera from unselected patients attending two london venereal disease clinics were examined by a microimmunofluorescence test. eleven egg-grown serotypes of chlamydia trachomatis and the so-called "fast" strain sa2(f) were used as antigens. of the 360 sera tested, 119 (33%) reacted to a titer of 1:16 or above with at least one antigen. of these positive sera, over 50% cross-reacted with all 12 serotypes, and 95.5% reacted with sa2(f) in addition to other antigenic types. it is ...1976783191
chlamydia trachomatis immunotype j.a new immunotype j is proposed for a group of chlamydia trachomatis strains which are related to trachoma type c in the microimmunofluorescence typing test. ten immunologically identical strains have been identified from four separate areas of the world. the strains were either isolated from the genital tract or from eye infection originating from the genital tract. they grow readily in hela 229 cell culture but poorly in egg culture. whereas two-way cross-reactions were found between types c an ...1975810514
the lack of effect of ampicillin plus probenecid given for genital infections with neisseria gonorrhoeae on associated infections with chlamydia trachomatis.forty-six men were successfully treated with a single oral dose of ampicillin (2 g) plus probenecid (1 g) for urethral infections with neisseria gonorrhoeae. chlamydia trachomatis was isolated from cultures of cells obtained from 11 of these men both before and after treatment; c. trachomatis was isolated from one man before but not after treatment and from three men after but not before treatment. no isolates were obtained from the remaining 31 men either before or after treatment. of the 15 pa ...1976816978
chlamydial infection of the male baboon urethra.two adult male baboons (papio cynocephalus) were infected by urethral catheter with a type d strain of chlamydia trachomatis isolated from a male patient with nongonococcal urethritis. chlamydial organisms were shed from the urethra for about 90 days and serum antibody developed. intraurethral re-inoculation of homologous and heterologous (type i) strains of chalmydia, 4 and 11 months later, resulted in relatively shorter periods of infection of less than 15 days. the antibody titres and type-sp ...1975811318
[present-day characteristics of diagnosis of trachoma]. 1975798392
the owl monkey (aotus trivirgatus) as an animal model in trachoma research.the owl monkey, aotus trivirgatus, in contrast to other species of nonhuman primates, was shown to be susceptable to infection with strains of chlamydia trachomatis. it responded to experimental infection with a severe, acute, inflammatory reaction of short duration. monkeys which recovered from infection were resistant to reinfection for more than 6 months and resistance was not strain specific. eye secretion antibody titers correlated well with resistance to subsequent challenge. these studies ...1976828229
chlamydial infection of the male urethra.urethral specimens from 477 men were collected with endourethral swabs and examined for chlamydia trachomatis by cell culture on mccoy cells pretreated with idoxuridine. of these men, 141 had gonococcal urethritis, 262 non-gonococcal urethritis (ngu), and 74 showed no evidence of urethritis. of 118 men with heterosexually acquired gonococcal urethritis, thirty (25 per cent.), and of 23 men with homosexually acquired gonococcal urethritis, five (22 per cent.), yielded c. trachomatis from the uret ...1976816416
severe persistent inclusion conjunctivitis in a young child.a 14-month-old girl had inclusion conjunctivitis although there had been no signs or symptoms that required medical attention in her first year. by 2 1/2 years of age, the child had extensive pannus and corneal scarring that severely reduced vision. the infection was caused by a genital strain of chlamydia trachomatis, tric type e, that was probably acquired at birth. although genitally transmitted chlamydial strains normally cause a self-limiting inclusion conjunctivitis in areas where trachoma ...1977848548
nongonococcal urethritis: the role of chlamydia trachomatis. 1977842992
respiratory-tract colonization and a distinctive pneumonia syndrome in infants infected with chlamydia trachomatis.to learn if chlamydia trachomatis causes in young infants a distinctive penumonia characterized by chronic, afebrile course, diffuse lung involvement and elevated serum immunoglobulins g and m, 47 black infants four to 24 weeks of age were examined for nasopharyngeal shedding of c. trachomatis and serum immunofluorescent antibody to lymphogranuloma venereum type i. nasopharyngeal c. trachomatis was found in 18 of 20 with the pneumonia syndrome, two of 15 with various other illnesses and 10 of 12 ...1977831128
serologic diagnosis of lymphogranuloma venereum by counterimmunoelectrophoresis with a chlamydia trachomatis protein antigen.previously a protein antigen was identified which was common to members of the species chlamydia trachomatis and to which antibody could be demonstrated in human sera by two-dimensional immunoelectrophoresis. the antigen has been purified by immunoadsorption chromatography, and an exploration undertaken to determine whether the detection of antibody to this antigen by counterimmunoelectrophoresis would be useful for the diagnosis of c. trachomatis infections. antibody was found in 43 of 45 (96%) ...1977839065
chilamydia trachomatis infection in patients with acute salpingitis.we examined the prevalence of chlamydia trachomatis in the cervix and the fallopian tubes of patients with acute salpingitis. cycloheximide-treated mccoy cells were used as the growth medium. for purposes of comparison, women with infections confined to the lower genital tract and women without signs of genital infections were also studied. c. trachomatis was isolated from the cervix in 19 of 53 patients with acute salpingitis, in one of 18 lower-genital-tract infections and in none of 12 withou ...1977859544
chlamydial infection of the urogenital tract in promiscuous and non-promiscuous women.chlamydia trachomatis infection of the urogenital tract of women presumed to be non-promiscuous, and in presumably promiscuous women attending a special clinic in manchester was studied. two hundred female members of hospital staff, who formed the non-promiscuous group, were found to have a 1% incidence of chlamydial infection. this compared with an incidence of 26% among 200 women attending the clinic. among the clinic patients, chlamydial infection was significantly linked with the presence of ...1977858067
the etiology of nongonococcal urethritis in men attending a venereal disease clinic.nongonococcal urethritis was identified as a major reason that men attended our venereal disease clinic. the prevalence of several agents that might cause nongonococcal urethritis was determined. attempts were made to isolate gonococci; chlamydiae, ureaplasms urealyticum, trichmonads, candida sp., and corynebacterium vaginale from urethral swabs from 307 men. chlamydiae were recovered from 31% of the 67 men with nongonococcal urethritis compared to only 4% of 86 asymptomatic men without pyuria. ...1977867205
isolation of chlamydia trachomatis from throat and rectum of homosexual men. 1977871895
chlamydial infection in neonates. 1977876336
neonatal conjunctivitis caused by neisseria gonorrhoeae and chlamydia trachomatis.in a selected group of 103 babies referred with neonatal conjunctivitis neisseria gonorrhoeae was isolated from 11 and chlamydia trachomatis from 33. concurrent infection was present in three. on toddler sibling developed chlamydial conjunctivitis. after treatment c. trachomatis was re-isolated from six babies during the follow-up period. the discharge started one to three days after delivery in only three babies with gonococcal conjunctivitis and at five to eight days in eight babies. one baby ...1977871893
isolation of chlamydia trachomatis from the male urethra.chlamydia trachomatis was isolated from 26% of urethral swabs taken from 509 men with urethritis. the highest yield of 68% was obtained from a selected group of men with nonspecific urethritis (nsu) who had a frank urethral discharge. this is a higher than in previous reports, and is significantly higher than the isolation of c. trachomatis from men with less severe urethritis. the higher yield was similar to c. trachomatis isolation rates reported among patients with severe trachoma in hyperend ...1977870145
urethritis due to chlamydia trachomatis.ninety-five men suffering from gonococcal urethritis were treated and observed. forty-nine developed postgonococcal non-specific urethritis (pgu). seventeen men were demonstrated to be free from pgu after careful observation; these formed a control group. chlamydia trachomatis was isolated from urethral material from 26 (53%) of the pgu group but from none of the controls. this difference was highly significant (p less than 0-001). it confirms that c. tachomatis is a pathogen in the urethra. the ...1977871894
the inactivation of chlamydia trachomatis by chlorhexidine ('hibitane'). 1977903334
limited survey of genital infection by guinea pig inclusion conjunctivitis agent.cervical or urethral scrapings were collected from 245 guinea pigs that had clinical signs of guinea pig inclusion conjunctivitis (gpic) or were parents of newborn young having clinical signs of gpic. giemsa-stained smears were examined for cytoplasmic inclusion bodies, and samples were passaged in 6-day-old embryonating eggs. complement-fixation tests were performed on 44 samples passaged through eggs in an effort to detect the presence of gpic antigen. unequivocal evidence of chlamydial infect ...1977921034
[irradiated cell cultures applied to group a "chlamydiae" isolation (author's transl)].the irradiated mc coy cell cultures method modified by darougar et al. has been used to investigate the frequency of chlamydiae in non-specific genital tract disease, in reiter's disease and in patients suffering from conjonctivits associated with non-specific urethritis. isolates were obtained from 104 men of the 660 suffering from acute urethritis, and from 18 men of the 67 suffering from conjonctivitis associated with urethritis. fourteen female sexual contacts of these men were tested: chlam ...1977921141
antimicrobial activity of several antibiotics and a sulfonamide against chlamydia trachomatis organisms in cell culture.minimum inhibitory concentrations of several antibiotics and a sulfonamide for growth of the 15 known immunotypes of chlamydia trachomatis were determined in hela 229 cell cultures. the concentrations for complete inhibition of infectious-organism production were (per milliliter): tetracycline, 0.02 to 0.5 mug; rosamicin, 0.05 to 0.25 mug; erythromycin, 0.1 to 0.5 mug; chloramphenicol, 10 mug; penicillin, 0.02 to 50 u; ampicillin, 0.1 to 50 mug; and sulfisoxazole, 2 to 200 mug. the same concentr ...1977883821
ophthalmia neonatorum associated with maternal chlamydial infections.an unselected sample of 142 pregnant women had a single cervical culture for c trachomatis at 36 to 40 weeks' gestation. of these women, 18 (12.7%) had positive cultures, and their infants were followed in postoperative fashion. of these 18 infants, eight (44%) developed ophthalmia neonatorum. a combination of cultures and conjunctival smears for giemsa staining and fluorescent-antibody examination for infected cells confirmed the diagnosis in 70% of the infants with conjunctivitis. however, 12 ...1977878139
survival of chlamydiae after cooling to -196 degrees c.factors influencing the survival of chlamydiae after freezing were reexamined. from the data presented, it is suggested that preservation of laboratory-grown chlamydiae is best achieved through the use of sucrose as the cryoprotective agent, in the presence of 10% serum. dimethyl sulfoxide and glycerol are more toxic. the period of exposure to sucrose before freezing must be kept as short as possible and be at 4 degrees c rather than at room temperature. the rate of cooling during freezing in su ...1977886008
the expanding clinical spectrum of infections with chlamydia trachomatis. 1977929347
bacteriology of the urethra in normal men and men with nongonococcal urethritis.sixty-nine caucasian males without a previous history of urethritis and who developed nongonococcal urethritis (ngu) and 39 similar men without urethritis (nu) were cultured from the urethra for chlamydia trachomatis, mycoplasma hominis, ureaplasma urealyticum, aerobes, and anaerobes. c. trachomatis infection was proven by culture of serology in 26 (38%) of the ngu group and 1 (3%) of the nu group; the c. trachomatis-negative ngu group had significantly more u. urealyticum (81%) than the c. trac ...1977925148
antibiotic susceptibility of chlamydia trachomatis.the antibiotic susceptibility of chlamydia trachomatis isolates was determined in a tissue culture system. representatives of all currently recognized serotypes of trachoma-inclusion conjunctivitis agents were tested. tetracycline and erythromycin yielded similar results, with 1.0 mug/ml preventing chlamydial replication. rifampin was the most active antibiotic, with 0.25 mug/ml completely suppressing inclusion formation of all strains. fifty percent end points were usually achieved at one-fourt ...1977931365
a method for testing the antibiotic susceptibility of chlamydia trachomatis in a cell culture system. 1976931835
characterization of miniature pig kidney cells and their resistance to chlamydial infection.a miniature pig kidney cell line has been established from porcine fetuses taken aseptically by hysterectomy and maintained for more than 50 passages in eagle's minimal essential medium containing 10% heat-inactivated newborn calf serum. cell transfers were performed each week. primary and serially passaged cells were found to be highly refractory to infection by chlamydia trachomatis strains tw-3, bour, and lgv 440l and chlamydia psittaci strains meningopneumonitis and 6bc and insusceptible to ...1976944002
the inactivation of chlamydia trachomatis by povidone-iodine. 1976945260
the gay bowel syndrome: clinico-pathologic correlation in 260 cases.the clinical and pathological findings in a group of 260 homosexual men comprising 10% of a private proctologic practice are reviewed. a clinical pattern of anorectal and colon diseases encountered with unusual frequency in these homosexual patients is termed the gay bowel syndrome. the clinical diagnoses in decreasing order of frequency include condyloma acuminata, hemorrhoids, nonspecific proctitis, anal fistula, perirectal abscess, anal fissure, amebiasis, benign polyps, viral hepatitis, gono ...1976946385
antibodies to two immunotypes of chlamydia trachomatis in individuals with trachoma.in tunisia (north africa), trachoma remains a common eye disease. most cases are caused by immunotype a of chlamydia trachomatis. in a small proportion of cases (less than 10%), type-specific antibodies to both immunotype a and immunotype b exist in the serum of patients. these types do not crossreact, and occasionally sequential acquisition of antibodies has been demonstrated. thus, individuals in one endemic area of trachoma may be infected with two immunotypes of c. trachomatis. the epidemiol ...1976971956
experimental study of the antitrachoma action of berberine. 1976992845
mediation of cytotoxic immune responses against human tumor-associated antigens by xenogeneic immune rna.xenogeneic immune rna (i-rna), extracted from the lymphoid organs of sheep or guinea pigs immunized with human tumor cells, mediated in vitro cytotoxic immune responses that were directed specifically against tumor-associated antigens of human tumor target cells. normal human peripheral blood lymphocytes from healthy donors became markedly more cytotoxic for human tumor target cells after being incubated with i-rna extracted from the lymphoid organs of animals that had been immunized with that p ...19761003510
differences in physicochemical and antigenic properties of chlamydial strains.antigenic analysis of chlamydia psittaci, c. trachomatis, and lymphogranuloma venereum (lgv) revealed basic physicochemical differences among the three chlamydial strains. these were manifested in structural, isoelectric points, absorption spectra, and in the characteristics of the chromophobe-containing proteins. the effective period of sonication for c. psittaci and c. trachomatis is around 60 min during which the linkages most susceptible to external sonication forces were broken, releasing a ...1976963615
infectivity titration of guinea-pig inclusion conjunctivitis agent in irradiated mccoy cells.estimation of the infectivity of the agent of guinea-pig inclusion conjunctivitis for irradiated mccoy cells, assayed as inclusion-forming units, was influenced by the age of cells after irradiation, the maturation time of the inclusions, the centrifugal force and the centrifugation temperature. agent passaged through irradiated mccoy cells or guinea-pig conjunctivae showed a greater capacity to infect irradiated mccoy cells without centrifuging than agent grown in a chick embryo. the nature of ...1976986419
analytical subfractionation of microsomal fractions from the livers of control and gunn-strain rats. 19761001660
serum alkaline phosphatase and glutamic oxalacetic transaminase in experimental intestinal ischemia. 19761011821
evaluation of the possible role of serum factors in the clearance of endotoxin from blood. 19761011822
depression of pancreatic bicarbonate response during endotoxic shock in dogs. 19761011823
effect of induced thrombocytopenia on experimental circulatory shock. 19761011824
thyroid-stimulating hormone and thyrocalcitonin content in rat thyroid. 19761011825
amylase clearance in acute pancreatitis experimental study in the guinea pig. 19761011827
the involvement of the electron transport chain in uptake of testosterone by membrane vesicles of pseudomonas testosteroni. 19761011843
lymphocyte locomotion iii. ultrastructural studies of the lymphocyte traffic over the postcapillary venules of rat lymph nodes.the direction of lymphocytes with amoeboid movement configuration (amc) was evaluated by means of electron microscopy of ultrathin sections of post-capillary high-endothelium venules (he-venules) from rat lymph nodes. out of 104 lymphocytes, 68 lymphocytes appeared to be on their way towards the lumen of the he-venule and 36 lymphocytes appeared to be moving away from the venular lumen at the moment of fixation. this difference, which was statistically significant (p=0.0024), is thought to refle ...19761011862
the microcirculation of the mammalian lymph node.flow alterations to give complete filling of the lymphatic sinusoidal system and saccular lymph spaces around the germinal centers were demonstrated during a primary immune reaction. by contrast, in delayed hypersensitivity, saccules were not seen although there was marked enlargement of individual follicular units.19761011863
[effect of estrogens on the electric activity of hypothalamic neurons and on the liberation of gonadotropic hormones in the ovariectomized rabbit]. 19761011931
thrombin. 19761011989
isolation of chlamydia trachomatis from women attending a clinic for sexually transmitted diseases.attempts were made to isolate chlamydia trachomatis from the cervix of 300 women attending a clinic for sexually transmitted diseases in leeds. the women were divided into four groups; (1) 130 were consorts of men suffering from non-specific urethritis; (2) 66 were suffering from gonorrhoea, or were consorts of men suffering from this disease; (3) 56 were suffering from other sexually transmitted diseases; (4) 48 had no evidence of std. the overall isolation rate of chlamydia trachomatis was 20% ...19761009420
the tric agent in the female genital tract; a cytologic and virologic study in a trachomatous hyperendemic area. 19761032928
a note on the effect of cooling rate, temperature of storage and packing material on the livability of ram spermatozoa. 19761026656
[relationship of the biological effect of radiation to the area of irradiated body surface].the dependece of radiation injury of piglets on the area of irradiated body surface (v 40 kv, eeff 17 key, 1 10 ma per tube, additional filter 0.1 mm a1, delta 1/2 0.08 mm a1, source--skin distance 30 cm, r 504 r/min, radiattion dose 200 r) was studied. the biological effect was evaluated with respect to the clinical, hematological and biochemical changes in the animal body. the data were obtained that indicated burn disease in the irradiated piglets, severity of which increased with an increase ...19761011787
preliminary report of a modified surgical approach to posterior digital neurectomy in the horse. 19761045701
cryotherapy of equine sarcoid and other lesions. 19761045702
conservative treatment of perianal fistula in a miniature poodle. 19761045724
effects of ampicillin-amikacin and ampicillin-rifampin on enterococci.fifty-seven clinical isolates of enterococcus were tested for susceptibility to 10 antibiotics in a microtiter broth dilution system. amoxicillin, ampicillin, vancomycin, and rifampin inhibited all strains at concentrations easily achievable in blood. resistance to rifampin developed rapidly. of the aminoglycosides, gentamicin was most active, followed in decreasing order by tobramycin, amikacin, kanamycin, and streptomycin. high-level resistance to streptomycin was present in 26% of the strains ...19761045914
mother-infant neonatal separation: some delayed consequences.an earlier study of mothers of premature and full-term infants showed that the type and amount of social interaction between a human mother and her infant in the immediate postpartum period can influence the mother's subsequent behaviour and attitude towards the infant. separation of a mother from her infant for as short a time as three weeks in the immediate postpartum period can lead to lowered feelings of maternal competency and decreased amounts of attachment behaviour, sometimes continuing ...19751045982
cognitive aspects of preverbal social interaction between human infants and adults.our previous studies on learning and on cognitive development in preverbal human infants indicated that motor activity and social interaction played particularly important roles in the cognitive development of infants. closer analysis has revealed that motor activity and social interaction have some underlying common regulatory mechanisms. these mechanisms can be detected more easily in infants than in older subjects. an attempt to synthesize our observations led us to the concept that there is ...19751045983
[resistance of the staphylococcus aureus isolated from patients operated on for cardiovascular diseases to penicillins, cephalosporins and the salts of heavy metals, their lysogenicity and phagotype].the analysis of the results obtained on the study of 55 strains of staph. aureus isolated from purulent excretion in the patients operated under conditions of artificial blood circulation provided a conclusion that most of the clinical staphylococcal cultures were highly resistant to the beta-lactamase sensitive antibiotics. it was supposed that the above strains possessed penicillinase plasmids, since all the cultures tested had penicillinase activity and were resistant to benzylpenicillin, the ...19751046354
metaphyseal osteopathy (hypertrophic osteodystrophy) in growing dogs. a clinical study. 19761011799
surgical repair of a fistula of the urethral diverticulum in a horse. 19761045700
the baby-milk controversy. 19761045358
homologous inhibitors from potato tubers of serine endopeptidases and metallocarboxypeptidases.a potent polypeptide inhibitor of chymotrypsin has been purified from russett burbank potatoes. the inhibitor has no effect on bovine carboxypeptidases a or b but exhibits homology with a carboxypeptidase inhibitor that is also present in potato tubers. the chymotrypsin inhibitor has a molecular weight of approximately 5400 as estimated by gel filtration, amino acid analysis, and titration with chymotrypsin. the polypeptide chain consists of 49 amino acid residues, of which six are half-cystine, ...19761064864
[clinical and animal experimental studies on the maxillary and mandibular alveolar processes after osteotomy. vii]. 19761068603
single-unit responses to natural vestibular stimuli and eye movements in deep cerebellar nuclei of the alert rhesus monkey.to study the possible role of the cerebellum in the vestibular-ocular reflex, extracellular responses of cerebellar nuclear neurons were recorded in awake monkeys during natural vestibular stimulation; 115 neurons in the fastigial nucleus responded to horizontal sinusoidal accelerations applied to the head by means of whole-body rotation. more than 75% of these cells were located in a distinct layer, 500 mum thick, in the rostral part of the fastigial nucleus; they were excited by contralateral ...19751079240
antigenic analysis of chlamydiae by two-dimensional immunoelectrophoresis. i. antigenic heterogeneity between c. trachomatis and c. psittaci.tw0-dimensional immunoelectrophoresis was used for the antigenic analysis of chlamydia. antigens of chlamydiae were found to be successfully solubilized with the nonionic detergent triton x-100. nineteen and 16 distinct components were observed for chlamydia trachomatis strain l2/434/bu and c. psittaci strain meningopneumonitis/cal-10, respectively. the triton-solubilized antigens of chlamydiae differ strikingly between species since only one strong reciprocal cross-reacting antigen was observed ...19751080772
[a case of pseudomonas infection in the oral cavity (author's transl)]. 19761087662
neutralization of chlamydia trachomatis in cell culture.neutralization of chlamydia trachomatis was assayed by the decrease in inclusion-forming units in baby hamster kidney cells grown in culture. five percent fresh guinea pig sera increased neutralization titers of rabbit antisera 100- to 1,000-fold but had no effect when normal rabbit sera were tested. neutralization of a type a or b trachoma isolate was strain specific. neutralization by human eye secretions and sera also was demonstrated when guinea pig sera were included in the test. all of the ...19751091549
treatment of spontaneous leukemia in akr mice with chemotherapy, immunotherapy, or interferon.akr mice are genetically destined to develop gross (rna) virus-induced lymphatic leukemia. leukemic akr mice treated with combination vincristine, cyclophosphamide (cytoxan), and 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea sustained a 180% increase of life-span. combination chemotherapy plus immunization with neuraminidase-treated allogeneic (gross virus-induced) g2g leukemic cells intradermally resulted in 35% of animals surviving beyond 150 days without evidence of the disease ...19761082796
bacteriuria in the catheterized patient. cystitis or pyelonephritis?seventy-two patients with indwelling urethral catheters had urine specimens cultured to detect bacteriuria. bacterial sediments were examined to find the source of the bacteria, with use of an antibody immunofluorescence (if) technique. antibody coating demonstrated by fluorescence was considered evidence for pyelonephritis. in cystitis, the bacteria did not fluoresce. repeat culture and immunofluorescence studies were done 3 to 18 week later. one third of the patients had a urinary infecti ...19751097745
simplified microimmunofluorescence test with trachoma-lymphogranuloma venereum (chlamydia trachomatis) antigens for use as a screening test for antibody.a simplified microimmunofluorescence test with trachoma-lymphogranuloma venereum (chlamydia trachomatis) antigens has been devised as a screening test for antibody in human sera. the test differs from our standard procedure by amalgamating 15 different immunotypes into nine antigen pools, by using only three serum dilutions, and by dropping use of duplicate slides. the screening test could be performed on at least six times as many sera as the standard test for a given unit of effort. it was sho ...19751100657
fluorescent antibody studies in chlamydial infections.irradiated mccoy cells infected with genital strains of chlamydia trachomatis were grown in wells on slides coated with polytetrafluoroethylene. the inclusions produced in this system formed the antigen in an indirect immunofluorescence test, which detected group-specific chlamydial antibodies in sera from patients attending veneral disease clinics. chlamydial antibodies were found more frequently and in higher titer in sera from women attending veneral disease clinics then in sera from a less p ...19751100663
b and t lymphocytes in man. ii. circulating b and t lymphocytes in cancer patients.b, t and "null" lymphocytes from 87 coded peripheral blood samples from 33 normals and 54 nonoperable or progressive cancer patients were determined. the controls have higher mean numbers of circulating lymphocytes than the cancer patients. radiation-treated cancer patients have lower values than non-irradiated patients. this phenomenon is also seen in the relative and absolute t, but not the b lymphocytes. there was no difference in the b lymphocytes among the different groups of patients. howe ...19761087640
light and electron microscopic study of chlamydia trachomatis infection of the uterine cervix.cervical biopsy specimens from two patients with infections caused by chlamydia trachomatis (tric agent) were studied by means of light and electron microscopy. intraepithelial vesicles containing c. trachomatis were present in the cervical mucosa. these intramucosal vesicles were readily recognized in paraffin sections by means of light microscopy. the developmental stages of c. trachomatis, which have previously been seen in tissue cell culture, chicken embryo, and conjunctival infections, wer ...19751094072
chlamydiae as agents of sexually transmitted diseases.chlamydiae are being increasingly recognized as an important cause of human disease. the known geographical distribution of lymphogranuloma venereum and the role of chlamydiae as agents of sexually transmitted diseases are reviewed. the presence of chlamydiae in the urethra and the cervix, and their etiological relationship to genital infections, first recognized in connexion with ocular infections, have been proved in a number of studies in selected populations in a few countries. chlamydiae ap ...19761088107
a rapid radiochemical method for the determination of choline acetyltransferase. 19751113118
the node of ranvier in experimental allergic neuritis: an electron microscope study.pathological breakdown of the node of ranvier in experimental allergic neuritis (ean) in the rabbit was examined by electron microscopy. the study was concerned principally with the mechanism of disruption of paranodal myelin. two types of change in myelin structure were observed, both apparently related to the presence of cytoplasmic processes of macrophages: (1) a vesicular disorganization of myelin lamellae and (2) a separation of myelin lamellae. both methods of disorganization were used by ...19751113142
cardiogenic oscillations of nitrogen and argon concentration in expired gas in man.1. the cardiogenic oscillations in the concentration of nitrogen and argon in expired gas, which are seen after the inspiration from residual volume of pure oxygen or a bolus of argon, have been studied in normal subjects and in patients with atrial fibrillation. 2. in the upright position of the subject, the peaks of nitrogen and argon concentration coincide with ventricular systole, although there is a transit delay along the tracheobronchial tree before any change of concentration occurs at t ...19751112079
identification of the elementary bodies of chlamydia trachomatis in the electron microscope by an indirect immunoferritin technique.an indirect immunoferritin (iif) technique is described for recognizing the elementary bodies (eb) of chlamydia trachomatis in unsectioned preparations. both the eb of a genital strain of c. trachomatis grown in irradiated mccoy cells and eb in clinical specimens obtained from patients attending a venereal disease clinic were identified by the iif test in the electron microscope. cell culture-grown eb were detected by ferritin staining for up to 4 weeks after the organisms had lost their infecti ...19751102559
lymphogranuloma venereum. 19761107239
letter: correlation of human menstruation and lunar phase. 19751119512
[penetration and resorption of substances through the skin from the clinical and experimental viewpoints]. 19751120285
letter: reactions of cartilage. 19751113834
regulation of spleen growth and portal pressure in hepatic shcistosomiasis.growth rate and histology of splenic autotransplants in subcutaneous pockets were compared with those of autotransplants in the extrahepatic portal bed in splenectomized mice infected with cercariae of schistosoma mansoni and in splenectomized uninfected controls. by the fifteenth week after transplantation (and tenth week after injection of cercariae) subcutaneous transplants gained 6.5 times and omental transplants 8.2 times more weight in infected animals than corresponding transplants in uni ...19751115219
effect of colchicine on collagen, albumin and transferrin synthesis by cirrhotic rat liver slices.collagen synthesis was found to be increased in liver slices of rats made cirrhotic by chronic administration of ccl4. the liver function was impaired, as determined by an increased retention of conjugated bilirubin and low serum albumin values. however, when animals received colchicine simultaneously with ccl4, collagen synthesis and deposition were inhibited, and the liver function appeared normal. when a group of rats was made cirrhotic by chronic administration of ccl4, and then kept for 30 ...19751115789
[proceedings: experimental study on surgical correction of acute myocardial infarct, with special emphasis on the effect of high pressure oxygen]. 19751121094
teratogenicity study in rats given high doses of pyridoxine (vitamin b6) during organogenesis. 19751120526
role of saline consumption in the prevention of deoxycorticosterone hypertension in rats by central 6-hydroxydopamine.1. the mechanism by which pretreatment of rats with intracisternal 6-hydroxydopamine prevents the onset of deoxycorticosterone hypertension has been studied. 2. rats pretreated with central 6-hydroxydopamine increase their consumption of 0-17 mol/l sodium chloride--0-03 mol/l potassium chloride ('saline') less than normal rats when implanted with deoxycorticosterone. 3. intact rats restricted to the equivalent consumption of saline of rats pretreated with 6-hydroxydopamine develop hypertension d ...19751126124
the mechanism of carcinogenic action of 1,2-dimethylhydrazine (sdmh) in rats.the radioactivity level in blood, bile, urine and contents of parts of the gastro-intestinal tract in rats was studied after subcutaneous administration of 3-h-1,2-dimethylhydrazine (3-h-sdmh) which induces colonic tumours. the alkylation of dna, rna and protein in the intestinal mucosa, liver and kidneys was estimated 1 h to 28 days after 3-h-sdmh treatment from the 3-h-incorporation into these macromolecules. administration of 3-h-1,2-diethylhydrazine (3-h-sdeh) which does not induce intestina ...19751140867
gluconeogenesis from alanine in normal postabsorptive man. intrahepatic stimulatory effect of glucagon.although the stimulatory effect of glucagon on gluconeogenesis has been well demonstrated in certain systems in vitro, this effect has never been established in man. the present study was undertaken, therefore, to determine whether glucagon could stimulate gluconeogenesis from alanine in normal fasting man. glucagon might stimulate this process by increasing the hepatic alanine uptake and/or by shunting the extracted alanine within the liver into the gluconeogenic pathway. in order to be able to ...19751140513
fertility of friesian heifers after luteolysis with a prostaglandin analogue (ici 80996). 19751146149
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