Publications

a novel whole-bacterial enzyme linked-immunosorbant assay to quantify chlamydia trachomatis specific antibodies reveals distinct differences between systemic and genital compartments.	chlamydia trachomatis (ct) is the leading sexually transmitted bacterial infection. the continued global burden of ct infection strongly predicates the need for a vaccine to supplement current chlamydial control programs. the correlates of protection against ct are currently unknown, but they must be carefully defined to guide vaccine design. the localized nature of chlamydial infection in columnar epithelial cells of the genital tract necessitates investigation of immunity at the site of infect ...	2017	28797112
assessing the need for routine screening for mycoplasma genitalium in the low-risk female population: a prevalence and co-infection study on women from croatia.	there is an ongoing debate regarding possible cost and benefits, but also harm of universal screening for the emerging sexually transmitted pathogen mycoplasma genitalium.	2017	28757928
retesting and repeat positivity following diagnosis of chlamydia trachomatis and neisseria gonorrhoea in new zealand: a retrospective cohort study.	testing for reinfection at 3 to 6 months following treatment for chlamydia trachomatis or neisseria gonorrhoea is recommended in best practice sexual health management guidelines. this study aimed to describe rates of retesting and repeat positivity following diagnosis of chlamydia or gonorrhoea in a defined geographic region of new zealand.	2017	28754106
population-based prevalence survey of follicular trachoma and trachomatous trichiasis in the casamance region of senegal.	trachoma, caused by ocular infection with chlamydia trachomatis, is the leading infectious cause of blindness worldwide. we conducted the first population-based trachoma prevalence survey in the casamance region of senegal to enable the senegalese national eye care programme (necp) to plan its trachoma control activities. the world health organization (who) guidelines state that any individual with trachomatous trichiasis (tt) should be offered surgery, but that surgery should be prioritised whe ...	2017	28747198
global survey of mrna levels and decay rates of chlamydia trachomatis trachoma and lymphogranuloma venereum biovars.	interpreting the intricate bacterial transcriptomics implies understanding the dynamic relationship established between de novo transcription and the degradation of transcripts. here, we performed a comparative overview of gene expression levels and mrna decay rates for different-biovar (trachoma and lymphogranuloma venereum) strains of the obligate intracellular bacterium chlamydia trachomatis. by using rna-sequencing to measure gene expression levels at mid developmental stage and mrna decay r ...	2017	28795162
il-4-secreting eosinophils promote endometrial stromal cell proliferation and prevent chlamydia-induced upper genital tract damage.	genital chlamydia trachomatis infections in women typically are asymptomatic and do not cause permanent upper genital tract (ugt) damage. consistent with this presentation, type 2 innate and th2 adaptive immune responses associated with dampened inflammation and tissue repair are elicited in the ugt of chlamydia-infected women. primary c. trachomatis infection of mice also causes no genital pathology, but unlike women, does not generate chlamydia-specific th2 immunity. herein, we explored the si ...	2017	28765368
the role of septins in infections with vacuole-dwelling intracellular bacteria.	septins are a relatively little understood group of gtpases that form large assemblies in cells from all eukaryotes other than plants. septins were first identified in cell division but have also been implicated in microbial infections. septins often associate with cytoskeletal proteins - most often described for filamentous (f-) actin - and are considered cytoskeletal components themselves. septins have increasingly been found to partake in processes that are linked to intracellular membranes, ...	2017	28784332
[chlamydia trachomaatis dna in leukocytes of peripheral blood from neonates].	diagnosis of chlamydia trachomatis infection in newborns is difficult; however, this diagnosis is performed by cell culture or by detection of igm antibodies against c. trachomatis. detection of c. trachomatis dna in peripheral blood leukocytes using polymer chain reaction (pcr) may be a better tool for the diagnosis of infection by this pathogen.	2017	25533744
fallopian tubes--literature review of anatomy and etiology in female infertility.	around 30% of the infertile women worldwide have associated fallopian tubes pathology. unfortunately, for a long time, this aspect of infertility has been neglected due to the possibility of bypassing this deadlock through ivf.	2017	25866566
prevalence of mycoplasma genitalium in men with urethritis and in high risk asymptomatic males in tel aviv: a prospective study.	we sought to investigate the prevalence of mycoplasma genitalium, chlamydia trachomatis, neisseria gonorrhoeae, and trichomonas vaginalis in men presenting to a sexually transmitted infection (sti) clinic, with special attention to m. genitalium, its occurrence in israeli patients, coinfections, and risk factors. in a cross-sectional study, 259 men were successively enrolled in the tel aviv levinsky clinic for stis between november 2008 and november 2010. there were 118 men with urethritis and 1 ...	2017	26826161
high prevalence of extra-genital chlamydial or gonococcal infections among men who have sex with men and transgender women in lima, peru.	chlamydia trachomatis and neisseria gonorrhoeae are among the most common sexually transmitted bacterial infections in the world. data are limited, however, on the burden of extra-genital chlamydial and gonococcal infections among men who have sex with men and transgender women in lima, peru. data were gathered from self-collected anal or pharyngeal swabs from participants in lima, peru, and analyzed via cross-sectional methods. prevalence ratios for the association between extra-genital infecti ...	2017	26846151
[what is the best treatment for urogenital chlamydia trachomatis infection?]		2017	27068255
ubiquitination of pathogen-containing vacuoles promotes host defense to chlamydia trachomatis and toxoplasma gondii.	many intracellular bacterial and protozoan pathogens reside within host cell vacuoles customized by the microbial invaders to fit their needs. within such pathogen-containing vacuoles (pvs) microbes procure nutrients and simultaneously hide from cytosolic host defense systems. among the many pv-resident human pathogens are the bacterium chlamydia trachomatis and the protozoan toxoplasma gondii. immune responses directed against their pvs are poorly characterized. we reported that activation of h ...	2017	27066178
the relationship between chlamydia trachomatis genital infection and spontaneous abortion.	chlamydia trachomatis is the etiology of most of sexually transmitted diseases. colonization of c. trachomatis in the genital tract during early gestation has been associated with preterm birth, and preterm premature rupture of the membranes. the role of c. trachomatis on spontaneous abortion has not yet been proved completely. the aim of this study was to evaluate the frequency of c. trachomatis infection among pregnant women and its association with spontaneous abortion.	2017	27141466
cervicitis: a prospective observational study of empiric azithromycin treatment in women with cervicitis and non-specific cervicitis.	treatment with 1 g azithromycin was observed prospectively in 130 women with cervicitis (>30 polymorphonuclear leucocytes/high-powered field) enrolled in a cervicitis aetiology study of 558 women at three sexually transmitted infection clinics in sydney, australia. two overlapping groups of women with cervicitis were considered: 'cervicitis group 1' (n = 116) excluded women with trichomonas vaginalis and a subgroup of this, 'cervicitis group 2' (non-specific cervicitis) (n = 96) further excluded ...	2017	26792283
ureaplasma urealyticum: presence among sexually transmitted diseases.	the aim of this study was to detect the presence of chlamydia trachomatis, neisseria gonorrhoeae, mycoplasma genitalium, mycoplasma hominis, trichomonas vaginalis, and ureaplasma urealyticum in genital specimens of symptomatic patients. this study also examined the role of u. urealyticum in infections of the lower genital tract. cervical and urethral samples from 96 patients (46 males, 50 females) were tested using the seeplex((®)) std6 ace kit. consent forms were received and a questionnaire wa ...	2017	27000449
health-related quality of life and chlamydia trachomatis infection in sexually experienced female inner-city students: a community-based cross-sectional study.	this cross-sectional study was undertaken to compare health-related quality of life (eq-5d) in women with and without undiagnosed chlamydia trachomatis infection. we analysed data from 2401 multi-ethnic sexually active female students aged 16-27 years who were recruited to a randomised controlled trial of chlamydia screening - the prevention of pelvic infection trial in 2004-2006. at recruitment, all participants were asked to provide self-taken vaginal swabs for chlamydia testing and to complet ...	2017	27154958
genital mycoplasma and chlamydia trachomatis infections in patients with genital tract infections attending a tertiary care hospital of north india.	limited data are available on the prevalence of genital mycoplasmas and chlamydia trachomatis (ct) among indian patients with genital tract infections. the objectives of the study were to determine the prevalence of ureaplasma urealyticum (uu), mycoplasma hominis (mh), mycoplasma genitalium (mg), and ct in patients with genital tract infections. the antimicrobial susceptibilities of uu and mh were also assessed. endocervical swabs/urethral swabs and first void urine samples of patients (n = 164) ...	2017	27166039
chlamydia sequelae cost estimates used in current economic evaluations: does one-size-fit-all?	current evidence suggests that chlamydia screening programmes can be cost-effective, conditional on assumptions within mathematical models. we explored differences in cost estimates used in published economic evaluations of chlamydia screening from seven countries (four papers each from uk and the netherlands, two each from sweden and australia, and one each from ireland, canada and denmark).	2017	27288417
the high-risk human papillomavirus e6 oncogene exacerbates the negative effect of tryptophan starvation on the development of chlamydia trachomatis.	chlamydia trachomatis is an obligate intracellular pathogen that requires specific essential nutrients from the host cell, one of which is the amino acid tryptophan. in this context interferon gamma (ifnγ) is the major host protective cytokine against chlamydial infections because it induces the expression of the host enzyme, indoleamine 2,3-dioxygenase 1, that degrades tryptophan, thereby restricting bacterial replication. the mechanism by which ifnγ acts has been dissected in vitro using epith ...	2017	27658027
prevalence of chlamydia trachomatis immunoglobulin g antibodies in infertile women attending an in vitro fertility center.		2017	26692622
the prevalence of causative organisms of community-acquired urethritis in an age group at high risk for sexually transmitted infections in korean soldiers.	this study was designed to evaluate the causative organisms in young male soldiers with clinical signs and symptoms after sexual contact that suggests a diagnosis of urethritis.	2017	26607860
rectal lymphogranuloma venereum in hiv-infected patients can mimic lymphoma.	an outbreak of rectal lymphogranuloma venereum (lgv) has been reported since 2003 in men who have sex with men, most of them being infected with human immunodeficiency virus. in these patients, unusual clinical presentations such as rectal tumor or intense lymphoproliferation on rectal biopsies may lead to an erroneous diagnosis of aggressive non-hodgkin lymphoma. three patients were referred to our center for the management of rectal b-cell non-hodgkin lymphoma on the basis of a rectal patholog ...	2017	26166139
chlamydia trachomatis infection and tubal infertility in port harcourt, southern,nigeria.	tubal occlusion remains one the commonest causes of infertility in our environment and previous pelvic infection have been implicated in the aetiology of the blockage objective: to demonstrate prior chlamydia infection in women with tubal factor infertility and ascertain the relationship between chlamydia and tubal occlusion.	2017	27492544
follicular conjunctivitis due to chlamydia felis-case report, review of the literature and improved molecular diagnostics.	a 29-year-old woman presented with unilateral, chronic follicular conjunctivitis since 6 weeks. while the conjunctival swab taken from the patient's eye was negative in a chlamydia (c.) trachomatis-specific pcr, c. felis was identified as etiological agent using a pan-chlamydia taqman-pcr followed by sequence analysis. a pet kitten of the patient was found to be the source of infection, as its conjunctival and pharyngeal swabs were also positive for c. felis. the patient was successfully treated ...	2017	28770201
the unique microbiology and molecular pathogenesis of mycoplasma genitalium.	mycoplasma genitalium is increasingly appreciated as a common cause of sexually transmitted disease syndromes, including urethritis in men and cervicitis, endometritis, pelvic inflammatory disease, and possibly preterm birth, tubal factor infertility, and ectopic pregnancy in women. despite these disease associations, which parallel those of chlamydia trachomatis and neisseria gonorrhoeae, the mechanisms by which this pathogen elicits inflammation, causes cellular damage, and persists in its onl ...	2017	28838077
mycoplasma genitalium infection in men.	mycoplasmagenitalium is one of the major causes of nongonococcal urethritis (ngu) worldwide but an uncommon sexually transmitted infection (sti) in the general population. the risk of sexual transmission is probably lower than for chlamydia trachomatis. infection in men is usually asymptomatic and it is likely that most men resolve infection without developing disease. the incubation period for ngu caused by mycoplasma genitalium is probably longer than for ngu caused by c. trachomatis. the clin ...	2017	28838074
pregnancy outcomes in association with stds including genital hsv-2 shedding in a south african cohort study.	genital herpes simplex virus-2 (hsv-2) shedding in pregnant women in association with neonatal herpes infection has been widely studied but there is limited evidence of its association with pregnancy outcomes.	2017	28396556
a macaque model for rectal lymphogranuloma venereum and non-lymphogranuloma venereum chlamydia trachomatis: impact on rectal simian/human immunodeficiency virus acquisition.	sustained genital tract inflammation caused by sexually transmitted infections (stis) is known to increase risk of vaginal human immunodeficiency virus (hiv) infections but, to our knowledge, there are no nonhuman primate studies that have evaluated its link to rectal hiv acquisition.	2017	28809773
urinary meatal swabbing detects more men infected with mycoplasma genitalium and four other sexually transmitted infections than first catch urine.	urinary meatal swabs compared with urine showed higher infection rates for mycoplasma genitalium (15.3% vs 12.6%, p = 0.035), chlamydia trachomatis (11.3% vs 9.3%, p = 0.039), neisseria gonorrhoeae (1.4% vs 1.1%, p = 1.00), trichomonas vaginalis (8.0% vs 1.7%, p < 0.001), and high-risk human papillomavirus (5.9% vs 3.4%, p = 0.078) respectively.	2017	28703728
seroprevalence of anti-chlamydia trachomatis igm in neonatal respiratory tract infections in hungary.	to determine the seroprevalence of specific igm indicative of respiratory tract infection (rti) due to chlamydia trachomatis (ct) among symptomatic infants.	2017	28771138
getting "inside" type i ifns: type i ifns in intracellular bacterial infections.	type i interferons represent a unique and complex group of cytokines, serving many purposes during innate and adaptive immunity. discovered in the context of viral infections, type i ifns are now known to have myriad effects in infectious and autoimmune disease settings. type i ifn signaling during bacterial infections is dependent on many factors including whether the infecting bacterium is intracellular or extracellular, as different signaling pathways are activated. as such, the repercussions ...	2017	28529959
trachomatous trichiasis and its management in endemic countries.	trichiasis is the sight-threatening consequence of conjunctival scarring in trachoma, the most common infectious cause of blindness worldwide. trachomatous trichiasis is the result of multiple infections from childhood with chlamydia trachomatis, which causes recurrent chronic inflammation in the tarsal conjunctiva. this produces conjunctival scarring, entropion, trichiasis, and ultimately blinding corneal opacification. the disease causes painful, usually irreversible sight loss. over eight mil ...	2017	22285842
mycoplasmateceae species are not found in fallopian tubes of women with tubo-peritoneal infertility.	the role of mycoplasmas on the development and sequelae of pelvic inflammatory disease remains controversial. the objective of the present study is to correlate directly the presence of mycoplasmateceae through polimerase chain reaction (pcr) determinations in cervix and fallopian tubes of infertile patients with tubo-peritoneal factor diagnosed through laparoscopy.	2017	22729196
prevalence of cervical chlamydia trachomatis infection in sexually active adolescents from salvador, brazil.	the incidence of sexually transmitted diseases among adolescents is increasing worldwide. genital chlamydia trachomatis infection is one of the most prevalent sexually transmitted diseases in young women, and undetected disease is highly associated with long-term complications in women. our goal was to determine the prevalence of cervical chlamydia trachomatis infection in a sexually active population of female adolescents from salvador, brazil, and to describe their socio-demographic, behaviora ...	2017	22552464