Publications

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development of a single base extension-tag microarray for the detection of pathogenic vibrio species in seafood.in this study, a single base extension-tag array on glass slides (sbe-tags) microarray was established to detect the seven leading seafood-borne pathogens, including vibrio parahaemolyticus, vibrio cholerae, vibrio vulnificus, vibrio mimicus, vibrio alginolyticus, vibrio anguillarum, and vibrio harveyi. three multiplex pcr assays were developed to specifically target the following species with individual gene markers, which are aads, tdh, and trh for v. parahaemolyticus; col, toxr, and vvh for v ...201021161212
development of a loop-mediated isothermal amplification assay for sensitive and rapid detection of the tdh and trh genes of vibrio parahaemolyticus and related vibrio species.thermostable direct hemolysin (tdh) and tdh-related hemolysin (trh) are the major virulence determinants of vibrio parahaemolyticus. trh is further differentiated into trh1 and trh2 on the basis of genetic and phenotypic differences. we developed a novel and highly specific loop-mediated isothermal amplification (lamp) assay for sensitive and rapid detection of the tdh, trh1, and trh2 genes of v. parahaemolyticus. the lamp assay was designed for both combined and individual detection of the tdh, ...201019966027
rapid identification and characterization of vibrio species using whole-cell maldi-tof mass spectrometry.vibrio identification by means of traditional microbiological methods is time consuming because of the many biochemical tests that have to be performed to distinguish closely related species. this work aimed at evaluating the use of maldi-tof mass spectrometry for the rapid identification of vibrio (v.) spp. as an advantageous application to rapidly discriminate the most important vibrio spp. and distinguish vibrio spp. from closely related bacterial species like photobacterium damselae and grim ...201020059616
occurrence of the vibrio cholerae seventh pandemic vsp-i island and a new variant.using comparative genomics, we identified a new variant of the vibrio seventh pandemic island-i (vsp-i). results of polymerase chain reaction (pcr) screening for both known vsp-i variants indicate that the novel variant is present only in non-o1/non-o139 strains of v. cholerae and vibrio mimicus. comparative genomics revealed little sequence divergence in the seventh pandemic vsp-i; however, a second insertion site located on the smaller chromosome was identified. although the seventh pandemic v ...201020141327
[simultaneous detection of vibrio cholerae o1 and o139 by real-time quantitative pcr].targeting the specific o-antigen gene cluster, a taq-man real-time fluorescence pcr assay was developed to detect 01 and o139 vibrio cholera concurrently and avoid frequently occurred false positives.201020364601
in vitro antibacterial, cytotoxic and antioxidant activities of plant nephelium longan.the petroleum ether, chloroform and ethyl acetate fractions of ethanol extract of leaf and stem from the plant nephelium longan (fam-sapindaceae) was subjected to antioxidant, antibacterial and cytotoxic activity. all the fractions showed potent antioxidant activity, of which the ethyl acetate and chloroform fraction of leaf demonstrated the strongest antioxidant activity with the ic50 value of 44.28 and 44.31 microg ml(-1), respectively. the petroleum ether extracts (500 microg disc(-1)) of lea ...201020415149
identification of non-coding rnas in environmental vibrios.the discovery of non-coding rna (ncrna) has been mainly limited to laboratory model systems and human pathogenic bacteria. in this study, we begin to explore the ncrna diversity in four recently sequenced environmental vibrio species (vibrio alginolyticus 40b, vibrio communis 1da3, vibrio mimicus vm573 and vibrio campbellii baa-1116) by performing in silico searches using infernal and rfam for the identification of putative ncrna-encoding genes. this search method resulted in the identification ...201020447992
interaction between vibrio mimicus and acanthamoeba castellanii.vibrio mimicus is a gram-negative bacterium, which causes gastroenteritis and is closely related to vibrio cholerae. the environmental reservoir of this bacterium is far from defined. acanthamoeba as well as vibrio species are found in diverse aquatic environments. the present study was aimed to investigate the ability of a. castellanii to host v. mimicus, the role of bacterial protease on interaction with a. castellanii and to disclose the ability of cysts to protect intracellular v. mimicus. c ...201020454692
discovery of novel vibrio cholerae vsp-ii genomic islands using comparative genomic analysis.this report describes vibrio seventh pandemic island ii (vsp-ii) and three novel variants revealed by comparative genomics of 23 vibrio cholerae strains and their presence among a large and diverse collection of v. cholerae isolates. three vsp-ii variants were reported previously and our results demonstrate the presence of three novel vsp-ii in clinical and environmental v. cholerae marked by major deletions and genetic rearrangements. a new vsp-ii cluster was found in the seventh pandemic v. ch ...201020528940
simultaneous differential detection of human pathogenic and nonpathogenic vibrio species using a multiplex pcr based on gyrb and pnta genes.to develop a multiplex pcr targeting the gyrb and pnta genes for vibrio species differentiation.201019891709
validation of a method for the detection of five species, serogroups, biotypes and virulence factors of vibrio by multiplex pcr in fish and seafood.in this work a sequential multiplex pcr system was designed and validated for the detection of most frequent foodborne pathogen vibrio species in fish and seafood (vibrio cholerae, vibrio parahaemolyticus, vibrio vulnificus, vibrio alginoliticus and vibrio mimicus). the method proposed functions in a hierarchical way, being composed of an end-point multiplex pcr to detect the presence of dna belonging to the studied species, followed by multiplex pcr and fragment analysis allowing the viability ...201019913702
[biochemical aspect in cardiac ischemia--ischemic changes and reperfusion injury]. 20102838873
interference of bromide in determination of serum chloride. 20103815810
renal growth after neonatal urinary tract infection.this study presents the result of 12-21 years' follow-up in a group of children with neonatal urinary tract infection (onset within 1 month after birth) in whom early renal growth retardation was noted without concomitant classical renal scarring. in all cases the neonatal infection was diagnosed and treated within a few days of onset and the patients were closely supervised thereafter. renal length, parenchymal thickness and area were measured at urography. at first follow-up (22 children, mean ...20103153287
the hypothalamic-pituitary-adrenal axis in depression. 20103035885
anticholinergic drugs in the treatment of airways disease. 20102861843
[epidemiologic investigations on caries prevalence among schoolchildren in brittany (france)].1421 randomly selected 6- to 15-year-old breton children were examined in 1987 in order to assess the prevalence of caries in permanent teeth. methods proposed by turlot & cahen (1989) were used. at 6, 85.9% of all children were caries-free and at 15, only 5.3%. at 14, dmft and dmfs rates reached 6.46 and 12.36, respectively. the differences of scores stated between boys and girls and between children from urban and rural regions were not statistically significant. pits and fissures were more fr ...20102799351
effects of blocked versus random practice by mentally retarded subjects on learning a novel skill.the purpose of this study was to assess the effects of different practice conditions on mentally retarded subjects learning a novel task. 20 subjects with a mean iq of 51.82 were randomly assigned to one of two practice conditions. the first group practiced at three different speeds (60, 30, and 15 rpm) on the pursuit rotor using a block arrangement in which each speed was practiced for five consecutive trials of 20 sec. duration before practicing at the next speed. the second group used random ...20102812988
[enterostoma therapy--a pilot course in the essen education center of the german nursing association]. 20113127632
physical and psychological sequelae to torture. a controlled clinical study of exiled asylum applicants.the study comprised 24 male lebanese refugees living in denmark. twelve of them alleged having been tortured in lebanon during the period 1981-85. the remaining twelve had neither been imprisoned nor tortured and thus acted as control persons. all the testimonies were found to be valid according to a method previously used by the author. the most common forms of torture were blows against the head, body and foot soles, suspension and asphyxiation. threats and solitary confinement were frequent, ...20113209147
[respiratory problems in patients with muscular dystrophy]. 20113285556
increased cough reflex associated with angiotensin converting enzyme inhibitor cough. 20113120857
darkroom diseases and how to combat them. 20113112384
valproate-associated hepatotoxicity and its biochemical mechanisms.intake of the anticonvulsant drug valproic acid, or its sodium salt, has been associated with occasional instances of severe and sometimes fatal hepatotoxicity. probably at least 80 cases have occurred worldwide. the syndrome affects perhaps 1 in 10,000 persons taking the drug, and usually develops in the early weeks or months of therapy. most instances have involved children, usually those receiving more than 1 anticonvulsant. multiple cases have occurred in 2 families. the typical presentation ...20113131628
annual summary 1984. reported morbidity and mortality in the united states. 20113092006
[x-ray computed tomography in venous pathology].after presenting the tomodensitometric semiology of venous thromboses in various territories, the authors define its indications. it is essentially in deep territories, head, chest and abdomen that the ct-scan is used to study and diagnose unrecognized thromboses as well as determine the venous repercussion of various neighboring ailments. the respective place of the ct-scan, ultrasonography and various phlebographies is analyzed.20113043474
structural variation of the superintegron in the toxigenic vibrio cholerae o1 el tor.to understand the genetic structures and variations of the superintegron (si) in vibrio cholerae isolated in the seventh cholera pandemic.201122365393
computer-aided molecular modelling: research study or research tool?developments in computational methods and equipment have produced a new type of research chemist, who prefers to calculate properties as well as measure them, either to gain a better understanding of microscopic molecular behaviour per se, or to guide a broader scientific study using a so-called 'rational' approach. while there is good reason to believe that significant results can be obtained this way, it is clear that only some of the 'tools of the trade' are sufficiently robust to present to ...20113236047
synthesis and antineoplastic effects of furo[3,4-d]pyrimidine derivatives.furo[3,4-d]pyrimidine was obtained in the reaction of 2-phenyl-4-phenylamino-6-methyl-5-pyrimidinecarboxylic acid with socl2. this compound, heated with aliphatic amines, yielded mono- and diamino-derivatives. some of the obtained compounds exhibited a potent antineoplastic activity.20113237569
oesophageal pain exacerbated by propranolol. 20113113570
[identification of vibrio mimicus bacteriophages].lysogeny was studied in vibrio mimicus; the indicator v. cholerae el tor strain was selected to identify phages. new v. mimicus phages were obtained and identified, which had a morphological similarity and an antigen affinity for morphological group i cholerae phages. phage differentiation revealed that morphological group i v. mimicus phages showed certain differences manifested as their lytic activity against v. cholerae strain 1322-69 of serovar 37 while this property was absent in cholerae p ...201121574461
design and validation of a novel multiplex real-time pcr assay for vibrio pathogen detection.three species--vibrio cholerae, vibrio parahaemolyticus, and vibrio vulnificus--account for the majority of vibrio infections in humans. rapid and accurate identification of vibrio species has been problematic because phenotypic characteristics are variable within species. additionally, biochemical identification and confirmation require 2 or more days to complete. rapid and sensitive molecular techniques for the detection of vibrio pathogens would be useful for the surveillance and management o ...201121669071
genome sequencing reveals unique mutations in characteristic metabolic pathways and the transfer of virulence genes between v. mimicus and v. cholerae.vibrio mimicus, the species most similar to v. cholerae, is a microbe present in the natural environmental and sometimes causes diarrhea and internal infections in humans. it shows similar phenotypes to v. cholerae but differs in some biochemical characteristics. the molecular mechanisms underlying the differences in biochemical metabolism between v. mimicus and v. cholerae are currently unclear. several v. mimicus isolates have been found that carry cholera toxin genes (ctxab) and cause cholera ...201121731695
Detection and characterization of pathogenic vibrios in shellfish by a Ligation Detection Reaction-Universal Array approach.Vibrios are a group of major foodborne pathogens widely distributed in marine environment. Vibrio cholerae, Vibrio parahaemolyticus, and Vibrio vulnificus are the pathogenic species of Vibrio that pose the greatest threat to human health. However, other vibrios, e.g. Vibrio alginolyticus, Vibrio mimicus and Grimontia hollisae, apparently less relevant in the group of foodborne pathogens, have been sporadically found in outbreaks. For seafood safety and economic purposes, a rapid and powerful met ...201122177227
reverse genetics approaches for cloning ril-1, a major locus involved in susceptibility to leukemia. 20123416638
evaluation of aerosolized triamcinolone acetonide as a replacement for aerosolized beclomethasone dipropionate.substitution of aerosolized triamcinolone acetonide for aerosolized beclomethasone dipropionate in treatment of 30 chronic asthmatics resulted in subjective improvement in all patients. there was reduction in requirement of systemic steroids and inhaled beta adrenergics. no adrenal suppression or oropharyngeal candidiasis occurred after replacing beclomethasone dipropionate with triamcinolone acetonide.20123528120
thyroglobulin and 131i uptake of remaining tissue in patients with differentiated carcinoma after thyroidectomy.in 158 thyroidectomized patients with well-differentiated non-metastatic thyroid cancer the results of serum thyroglobulin (tg) determination and 131i uptake values established immediately before radioiodine treatment (19 days after surgery) were compared. in 113 patients (72%) tg was above 6 ng ml-1 (lower limit of detection) and 131i uptake exceeded 2%. in 11 patients (7%) tg was undetectable and 131i uptake less than 2%. in these cases a radioiodine treatment was not performed; the thyroid ab ...20123399222
[ambulatory observation of patients with neuritis of the optic nerve]. 20123387000
effects of adult and peer social initiations on the social behavior of withdrawn, maltreated preschool children. 20123346446
a pedigree of leber's congenital amaurosis.a pedigree of leber's congenital amaurosis compatible with autosomal recessive trait is reported. two male infants from consanguineous parents had remarkable visual loss within the first year of life, with sluggish pupillary responses, poor fixations, minimal eyeground changes and absent electroretinograms on presentations at the ages of four or 14 months. follow-up studies revealed definite progressions of eyeground abnormalities consisting of attenuated retinal arterioles, pepper- and salt-lik ...20123405591
genome sequence and comparative genomics analysis of a vibrio cholerae o1 strain isolated from a cholera patient in malaysia.the genome sequence analysis of a clinical vibrio cholerae vc35 strain from an outbreak case in malaysia indicates multiple genes involved in host adaptation and a novel na(+)-driven multidrug efflux pump-coding gene in the genome of vibrio cholerae with the highest similarity to vma_001754 of vibrio mimicus vma223.201223209200
rapid and sensitive quantification of vibrio cholerae and vibrio mimicus cells in water samples by use of catalyzed reporter deposition fluorescence in situ hybridization combined with solid-phase cytometry.a new protocol for rapid, specific, and sensitive cell-based quantification of vibrio cholerae/vibrio mimicus in water samples was developed. the protocol is based on catalyzed reporter deposition fluorescence in situ hybridization (card-fish) in combination with solid-phase cytometry. for pure cultures, we were able to quantify down to 6 v. cholerae cells on one membrane with a relative precision of 39% and down to 12 cells with a relative precision of 17% after hybridization with the horseradi ...201222885749
cervical lymph node metastases with occult primary.patients with cervical metastases from an unknown primary tumour present both diagnostic and therapeutic problems. twenty patients with a metastatic lesion in the neck, in whom the primary tumour was not found despite extensive, diagnostic procedures, were treated in the department of otolaryngology, linköping university hospital, during a 14-year period (1971-1984). since 1975 tonsillectomy has been performed regularly on the affected side as a part of the diagnostic procedure. eight patients w ...20123815873
agoraphobia and parental bereavement.the prevalence of parental bereavement was determined in 50 married female outpatients with a dsm-iii diagnosis of agoraphobia and in a control group of married female outpatients diagnosed as having non-psychotic psychiatric disorders other than agoraphobia. the two groups were matched for age and overall severity of psychiatric symptoms. compared with the general population, the patient control group reported a statistically significant excess of parental, but not maternal, bereavement. the ag ...20123435374
[studies on the blood constituents of the neonates delivered by the induced delivery of the defense medical college method].for the assessment of the influence of the defense medical college planned delivery method upon neonates, the measurement of the blood constituents of the umbilical cord was conducted. statistically speaking, no marked differences were seen between the neonates delivered by the defense medical college method and neonates delivered naturally. the blood constituents investigated were: blood cells, activity of various enzymes, other blood constituents and electrolytes.20123457089
natural cooling of the brain during outdoor bicycling?tympanic membrane temperature (ttymp) and deep esophageal temperature (tes) were measured in 8 subjects during normal outdoor bicycling. metabolic rate (vo2) was determined by the douglas bag method. heart rate was sampled continuously. skin surface temperatures were measured at the forehead, chest and shoulder, and core temperatures in the deep esophagus and at the tympanic membrane using a radio telemetry system. for each outdoor experiment an indoor experiment in a climatic chamber, adjusted ...20123399365
smooth muscle tumours of the digestive tract: report of 160 cases.of 160 patients seen in the period 1951-84 with smooth muscle tumours of the digestive tract, 71 proved to have leiomyomas, 87 had leiomyosarcomas and 2 had leiomyoblastomas. tumour diameter was frequently greater in patients with leiomyosarcoma. the surgical mortality was 2.8 per cent after treatment of leiomyoma and 10.3 per cent after treatment of leiomyosarcoma. after resection of leiomyosarcoma the 2-year survival rate was 86 per cent and the 5-year survival rate was 43 per cent. the only h ...20123349313
commonly adopted postures and their effect on the lumbar spine.the activity of the erector spinae muscles and the changes in lumbar curvature were measured in 11 subjects in a range of commonly adopted postures to see if there were any consistent trends. surface electrodes were used to measure back muscle activity and lumbar curvature was measured using electronic inclinometers. the results showed that many commonly adopted postures reduced the lumbar lordosis when compared with erect standing or sitting, even at the expense of increasing the back muscle ac ...20123406840
examining the fish microbiome: vertebrate-derived bacteria as an environmental niche for the discovery of unique marine natural products.historically, marine invertebrates have been a prolific source of unique natural products, with a diverse array of biological activities. recent studies of invertebrate-associated microbial communities are revealing microorganisms as the true producers of many of these compounds. inspired by the human microbiome project, which has highlighted the human intestine as a unique microenvironment in terms of microbial diversity, we elected to examine the bacterial communities of fish intestines (which ...201222574119
vibrio mimicus infection associated with crayfish consumption, spokane, washington, 2010.we report a cluster of severe diarrheal disease caused by vibrio mimicus infection among four persons who had consumed leftover crayfish the day after a private crayfish boil. gastrointestinal illness caused by vibrio mimicus has not been reported previously in washington state. three cases were laboratory confirmed by stool culture; using pcr, isolates were found to have ctx genes that encode cholera toxin (ct). two of the cases were hospitalized under intensive care with a cholera-like illness ...201222488068
dietary organic selenium improves growth, survival and resistance to vibrio mimicus in cultured marron, cherax cainii (austin, 2002).to determine the effects of dietary organic selenium (os) supplementation on the growth performance and immune competence of marron, cherax cainii (austin, 2002), a group of marron were fed 0.2 g kg(-1) of sel-plex(®) supplemented basal diet and then compared with another group (control) of marron fed basal diet without any supplementation. after 90 days of feeding, final weight, average weekly gains (awg), relative gain rate (rgr), specific growth rate (sgr), survival, total and differential ha ...201323603239
hemolytic and urease activities in vibrios isolated from fresh and frozen oysters.the present study aimed to survey the vibrio microbiota of oysters (crassostrea rhizophorae) obtained from restaurants in fortaleza, state of ceará, brazil, and to identify virulence factors.201323563836
draft genome sequence of vibrio mimicus strain caim 602t.vibrio mimicus is a gram-negative bacterium associated with gastrointestinal diseases in humans around the world. we report the complete genome sequence of the vibrio mimicus strain caim 602(t) (cdc1721-77, lmg 7896(t), atcc 33653(t)).201323516211
identification and immunogenicity of immunodominant mimotopes of outer membrane protein u (ompu) of vibrio mimicus from phage display peptide library.vibrio mimicus (v. mimicus) is the causative agent of ascites disease in aquatic animals. outer membrane protein u (ompu) is an important antigen of v. mimicus, but its protective epitopes are still unclear. a random 12-mer phage-displayed peptide library was used to screen and identify immunodominant mimotopes of the ompu protein in v. mimicus by panning against purified ompu-specific polyclonal antibody. then the immunogenicity and immunoprotection in fish of these mimotopes was evaluated. nin ...201323178262
architecture of the superintegron in vibrio cholerae: identification of core and unique genes.vibrio cholerae, the etiologic agent of cholera, is indigenous to aquatic environments. the v. cholerae genome consists of two chromosomes; the smallest of these harbors a large gene capture and excision system called the superintegron (si), of ~120 kbp. the flexible nature of the si that results from gene cassette capture, deletion and rearrangement is thought to make it a hotspot of v. cholerae diversity, but beyond the basic structure it is not clear if there is a core genome in the si and if ...201325580216
relationship of aquatic environmental factors with the abundance of vibrio cholerae, vibrio parahaemolyticus, vibrio mimicus and vibrio vulnificus in the coastal area of guaymas, sonora, mexico.members of the genus vibrio are common in aquatic environments. among them are v. cholerae, v. vulnificus, v. parahaemolyticus and v. mimicus. several studies have shown that environmental factors, such as temperature, salinity, and dissolved oxygen, are involved in their epidemiology. therefore, the main objective of this study is to determine if there is a correlation between the presence/amount of v. cholerae, v, vulnificus, v. parahaemolyticus and v. mimicus and the environmental conditions ...201324334844
in vitro and in vivo bactericidal activity of vitex negundo leaf extract against diverse multidrug resistant enteric bacterial pathogens.to investigate in vitro and in vivo antibacterial potentials of vitex negundo (v. negundo) leaf extracts against diverse enteric pathogens.201323608373
haemothorax in the course of chickenpox. 20133787528
[vesico-uterine fistulas]. 20133623249
recommendations for research in the epidemiology of asthma. 20133581962
reference ranges and ideal patient values for blood cholesterol. can there be reconciliation?reference ranges for blood cholesterol levels reflect the nationwide epidemic of "silent" hypercholesterolemia. as such, reference ranges for cholesterol levels without accompanying designation of levels associated with increased coronary risk are misleading and falsely comforting to physicians and patients. in a recent continent-wide study of 108 academically based clinical laboratories, highly variable reference ranges were observed, the ranges having been derived from a vast assortment of sou ...20133754717
meta-analyses of randomized controlled trials.a new type of research, termed meta-analysis, attempts to analyze and combine the results of previous reports. we found 86 meta-analyses of reports of randomized controlled trials in the english-language literature. we evaluated the quality of these meta-analyses, using a scoring method that considered 23 items in six major areas--study design, combinability, control of bias, statistical analysis, sensitivity analysis, and application of results. only 24 meta-analyses (28 percent) addressed all ...20133807986
temporal lobe epilepsy with schizophrenia.i have reported a case of coexisting schizophrenia and complex partial seizures to augment earlier reports of schizophrenia and psychomotor seizures masquerading as one another. i have attempted to clarify the differential diagnosis and reinforce the need to do thorough studies in such cases.20133616704
repeatability of phasic muscle activity: performance of surface and intramuscular wire electrodes in gait analysis.repeatability is an important consideration for gait analysis data that are being used as an adjunct to clinical decision making. an index of repeatability may be based on a statistical criterion (variance ratio) that reflects similarity of wave forms over a number of identical cycles. the purpose of this study was to use the variance ratio to assess the repeatability of phasic muscle activity recorded with surface and bipolar intramuscular wire electrodes during gait on 10 normal subjects. vari ...20134032106
immunological responses of customised probiotics-fed marron, cherax tenuimanus, (smith 1912) when challenged with vibrio mimicus.a two-phased experiment was conducted to investigate the effects of dietary supplementation of customised probiotics on marron physiology. during the first phase marron were fed probiotic supplemented feed for 70 days, while in phase two the same marron were challenged with vibrio mimicus and their physiological responses were investigated for 4 days post-challenged. the experiment was carried out in a purpose-built room, designed for aquaculture research, using 18 of 250 l cylindrical plastic t ...201323643874
the role of the paediatric endoscopist.the role of the paediatric endoscopist has been a changing one. when i first commenced at the royal alexandra hospital for children in sydney 25 years ago, paediatric endoscopy of the upper respiratory tract and oesophagus was a limited and poorly defined field. most endoscopic examinations were requested, often reluctantly, by a paediatrician in the investigation of stridor. in fact my first consultation involved instructions to perform a laryngoscopy, but not a bronchoscopy and general anaesth ...20133805880
[in vitro fertilization in reduced male fertility]. 20134029742
[pathogenesis and treatment of arterial hypertension in hypothyroidism patients]. 20133784472
[clinical chemistry of the cerebrospinal fluid]. 20133720593
[factors determining the severity of traumatic lesions of the popliteal artery]. 20134073583
three generations building on history. 20133622966
emergency room thoracotomy for stab wounds to the chest and neck.this study group comprises 73 patients who underwent emergency room resuscitative thoracotomy for cardiac arrest following penetrating chest and neck injuries. overall, 12 patients (16.4%) were successfully resuscitated but only five (6.8%) left the hospital alive without neurologic defects. none of the 18 cases with no vital signs at all (no cardiac activity, no respiratory efforts, nonreactive pupils) on admission survived. only one out of the 19 cases with no cardiac activity and with fixed p ...20133573102
local anaesthetics. iv--synthesis and activity of 2-(n-substituted or n,n-disubstituted aminoacetamido)-4- or -4,5-substituted thiazoles.synthesis is described of eleven new 2-(n-substituted or n,n-disubstituted aminoacetamido)-4- or -4,5-substituted thiazoles (i). their hydrochlorides were screened for local anaesthetic activity on frogs by the sciatic plexus method and the activity compared with that of procaine.20133792539
change of blood pressure over five years in childhood and adolescence.we compared blood pressure (bp) values, measured at a five year interval, in 2,777 boys and girls aged 4-18 years. bp values were converted into height and sex adjusted standard deviation unit scores. correlation coefficients were significant but low for systolic bp score: 0.19 in boys and 0.15 in girls, and were even lower for diastolic bp score. these correlations are weaker than those observed for overall bp values (boys: 0.33, girls: 0.23), weight (0.82, 0.75) and height (0.87, 0.80). the pr ...20133757275
diagnosis and treatment of chalazia.a patient with recurrent chalazia is described. this patient also had acne rosacea. the clinical and histologic characteristics of chalazia are described. in addition, therapy for chalazia is presented, with emphasis being given to conservative therapy.20133734179
[acoustic indicator of membrane potential levels]. 20133609385
[organization of the regular schedules of forensic-medical experts at a bureau of forensic medical examinations]. 20144071589
physiology of the upper airways in allergic disease. 20143902190
galvanic skin responses (gsr) and plethysmographic changes induced by chlorimipramine, imipramine and placebo. 20144209521
torsade de pointes: a maximal vulnerability arrhythmia. 20143966319
noninvasively diagnosed peripheral arterial disease as a predictor of mortality: results from a prospective study.intermittent claudication has been reported in previous studies to approximately double the risk of subsequent mortality. however, a history of claudication is often present in the absence of significant peripheral arterial disease (pad) and absent in the presence of pad. for this reason we evaluated the association between large-vessel and small-vessel pad, measured by highly reliable and valid noninvasive tests, and mortality in 567 older subjects from a defined population followed-up for an a ...20144028377
overdose with baclofen. 20143945841
the feasibility of an assistant to the physician. 20144152241
the vascular pathology of thrombotic thrombocytopenic purpura. an immunohistochemical and ultrastructural study. 20144161747
[prostatectomy and amputatio recti]. 20144103378
distribution and elimination of [14c]-hexachlorobenzene after single oral exposure in cod (gadus morhua) and flounder (platichthys flesus).distribution and elimination of hexachlorobenzene (hcb) after administration to cod (gadus morhua) of a single oral dose of 5 microci [14c]hcb/100 g body weight were studied by whole-body autoradiography and liquid scintillation counting. to obtain some information on the physicochemical properties of the radiolabeled compounds, whole-body autoradiography was performed exposing parallel sagittal sections, treated at -20 degrees c, evaporated at 50 degrees c, and extracted separately with polar a ...20144078931
family history of cancer among cancer patients.family history of cancer was examined for 9,131 cancer patients who were reported to the aichi cancer registry in 1979-1981, and were over 20 years old at diagnosis. the rate of patients whose parents and/or siblings had cancer of any site was 24.5%. the rate was 9.2% for father, 8.4% for mother, 6.0% for brother(s), and 5.2% for sister(s). a significant site concordance between study patient and family member with cancer was observed for cancer of the breast, colon and rectum, and stomach. the ...20143920100
letter: brain-levels of monoamine oxidase in depression. 20144136104
the use of multivariate techniques in the study of skeletal populations. 20144313256
[new studies on a relationship between hemoglobins and rhesus factors in africans]. 20144308643
[new studies on a relationship between hemoglobins and rhesus factors in africans]. 20144308643
velopharyngeal insufficiency in children: the variable clinical presentation. 20143957645
development of a selective and differential medium for capsulated lactococcus garvieae.a selective and differential medium termed 'lg agar' was developed for the isolation and presumptive identification of lactococcus garvieae that results in black colonies with red halos. in this study, all 14 strains of l. garvieae and only 9 of the 148 strains representing 38 other species were able to grow on the lg agar. the nine viable strains on lg agar plates (including enterococcus faecalis, enterococcus faecium, lactococcus lactis, vibrio fluvialis, vibrio furnissii, vibrio mimicus and v ...201424033791
blood transfusion and athletics. games people play. 20143974666
[pacemaker implantation in infants and children for atrioventricular block]. 20143819491
[conservative treatment of injuries of the liver]. 20143911104
a novel extracellular protease of vibrio mimicus that mediates maturation of an endogenous hemolysin.vibrio mimicus, a human pathogen that causes gastroenteritis, produces an enterotoxic hemolysin as a virulence factor. the hemolysin is secreted extracellularly as an inactive protoxin and converted to a mature toxin through removal of the n-terminal propeptide, which comprises 151 amino acid residues. in this study, a novel protease having the trypsin-like substrate specificity was purified from the bacterial culture supernatant. the n-terminal amino acid sequence of the purified protein was id ...201425040152
first pediatric case of chromobacterium haemolyticum causing proctocolitis.bloody diarrhea in children is usually due to either infectious or inflammatory etiology, but infection is far more common than inflammatory bowel disease in children worldwide. if, however, the patient has unfavorable response to antibiotics and a definite infectious agent has yet to be identified; colonoscopy should be performed. the current patient presented with acute onset of mucous bloody diarrhea. stool culture was initially identified as vibrio mimicus and later identified as aeromonas s ...201425252051
the master activator of inca/c conjugative plasmids stimulates genomic islands and multidrug resistance dissemination.dissemination of antibiotic resistance genes occurs mostly by conjugation, which mediates dna transfer between cells in direct contact. conjugative plasmids of the inca/c incompatibility group have become a substantial threat due to their broad host-range, the extended spectrum of antimicrobial resistance they confer, their prevalence in enteric bacteria and their very efficient spread by conjugation. however, their biology remains largely unexplored. using the inca/c conjugative plasmid pvcr94δ ...201425340549
vibrio parahaemolyticus and its specific bacteriophages as an indicator in cockles (anadara granosa) for the risk of v. parahaemolyticus infection in southern thailand.correlation between the numbers of vibrio parahaemolyticus and its specific bacteriophages in cockles was investigated from june 2009 to may 2010 in hat yai, songkhla, thailand. cockles obtained monthly from a local market were sampled to determine the numbers of v. parahaemolyticus and bacteriophages that could form plaques on ten strains of pandemic and nonpandemic v. parahaemolyticus. in addition, v. parahaemolyticus isolates from clinical samples from hat yai hospital over the same period we ...201424682339
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