Publications

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classic spotlight: studies on the low-calcium response of yersinia pestis reveal the secrets of plague pathogenesis. 201627413177
outbreak of plague in a high malaria endemic region - nyimba district, zambia, march-may 2015.outbreaks of plague have been recognized in zambia since 1917 (1). on april 10, 2015, zambia's ministry of health was notified by the eastern provincial medical office of possible bubonic plague cases in nyimba district. eleven patients with acute fever and cervical lymphadenopathy had been evaluated at two rural health centers during march 28-april 9, 2015; three patients died. to confirm the outbreak and develop control measures, the zambia ministry of health's field epidemiology training prog ...201627513350
plasmid ppcp1-derived srna hmsa promotes biofilm formation of yersinia pestis.the ability of yersinia pestis to form a biofilm is an important characteristic in flea transmission of this pathogen. y. pestis laterally acquired two plasmids (ppcp1and pmt1) and the ability to form biofilms when it evolved from yersinia pseudotuberculosis. small regulatory rnas (srnas) are thought to play a crucial role in the processes of biofilm formation and pathogenesis.201627492011
adjunctive corticosteroid treatment against yersinia pestis improves bacterial clearance, immunopathology, and survival in the mouse model of bubonic plague.plague is initiated by yersinia pestis, a highly virulent bacterial pathogen. in late stages of the infection, bacteria proliferate extensively in the internal organs despite the massive infiltration of neutrophils. the ineffective inflammatory response associated with tissue damage may contribute to the low efficacy of antiplague therapies during late stages of the infection. in the present study, we address the possibility of improving therapeutic efficacy by combining corticosteroid administr ...201627402776
assessment of live plague vaccine candidates.since its creation in the early twentieth century, live plague vaccine ev has been successfully applied to millions of people without severe complications. this vaccine has been proven to elicit protection against both bubonic and pneumonic plague, and it is still in use in populations at risk mainly in the countries of the former soviet union. despite extensive efforts in developing subunit vaccines, there is a reviving interest in creation of a precisely attenuated strain of yersinia pestis su ...201627076149
multiple antigens of yersinia pestis delivered by live recombinant attenuated salmonella vaccine strains elicit protective immunity against plague.based on our improved novel salmonella vaccine delivery platform, we optimized the recombinant attenuated salmonella typhimurium vaccine (rasv) χ12094 to deliver multiple yersinia pestis antigens. these included lcrv196 (amino acids, 131-326), psn encoded on pya5383 and f1 encoded in the chromosome, their synthesis did not cause adverse effects on bacterial growth. oral immunization with χ12094(pya5383) simultaneously stimulated high antibody titers to lcrv, psn and f1 in mice and presented comp ...201627060051
[sympatric speciation of the plague microbe yersinia pestis: monohostal specialization in the host-parasite marmot-flea (marmota sibirica-oropsylla silantiewi) system].an ecological scenario of the origin of the plague microbe that is interpreted in the light of modern darwinism (synthetic theory of evolution) is presented. it is shown that the plague microbe emerged from a clone of the psychrophilic saprozoonotic pseudotuberculosis microbe yersinia pseudotuberculosis o:1b in the mountain steppe landscapes of central asia in the sartan time, 22000-15000 years ago, in the monohostal mongolian marmot (marmota sibirica)-flea (oropsylla silantiewi) host-parasite s ...201627396172
reannotation of yersinia pestis strain 91001 based on omics data.yersinia pestis is among the most dangerous human pathogens, and systematic research of this pathogen is important in bacterial pathogenomics research. to fully interpret the biological functions, physiological characteristics, and pathogenesis of y. pestis, a comprehensive annotation of its entire genome is necessary. the emergence of omics-based research has brought new opportunities to better annotate the genome of this pathogen. here, the complete genome of y. pestis strain 91001 was reannot ...201627382076
expression and association of the yersinia pestis translocon proteins, yopb and yopd, are facilitated by nanolipoprotein particles.yersinia pestis enters host cells and evades host defenses, in part, through interactions between yersinia pestis proteins and host membranes. one such interaction is through the type iii secretion system, which uses a highly conserved and ordered complex for yersinia pestis outer membrane effector protein translocation called the injectisome. the portion of the injectisome that interacts directly with host cell membranes is referred to as the translocon. the translocon is believed to form a por ...201627015536
temporal progression of pneumonic plague in blood of nonhuman primate: a transcriptomic analysis.early identification of impending illness during widespread exposure to a pathogenic agent offers a potential means to initiate treatment during a timeframe when it would be most likely to be effective and has the potential to identify novel therapeutic strategies. the latter could be critical, especially as antibiotic resistance is becoming widespread. in order to examine pre-symptomatic illness, african green monkeys were challenged intranasally with aerosolized yersinia pestis strain co92 and ...201627003632
proteolysis of plasminogen activator inhibitor-1 by yersinia pestis remodulates the host environment to promote virulence.essentials effect of plasminogen activator inhibitor (pai)-1 on plague and its y. pestis cleavage is unknown. an intranasal mouse model of infection was used to determine the role of pai-1 in pneumonic plague. pai-1 is cleaved and inactivated by the pla protease of y. pestis in the lung airspace. pai-1 impacts both bacterial outgrowth and the immune response to respiratory y. pestis infection. click to hear dr bock discuss pathogen activators of plasminogen.201627377187
plague in arab maghreb, 1940-2015: a review.we reviewed the epidemiology of 49 plague outbreaks that resulted in about 7,612 cases in 30 localities in the arabic maghreb (mauritania, morocco, algeria, tunisia, libya, and egypt) over 75 years. between 1940 and 1950, most cases recorded in morocco (75%) and egypt (20%), resulted from plague imported to mediterranean harbors and transmitted by rat ectoparasites. by contrast, the re-emergence of plague in the southern part of western sahara in 1953 and in northeast libya in 1976 was traced to ...201627376053
differential regulation of c-di-gmp metabolic enzymes by environmental signals modulates biofilm formation in yersinia pestis.cyclic diguanylate (c-di-gmp) is essential for yersinia pestis biofilm formation, which is important for flea-borne blockage-dependent plague transmission. two diguanylate cyclases (dgcs), hmst and hmsd and one phosphodiesterase (pde), hmsp are responsible for the synthesis and degradation of c-di-gmp in y. pestis. here, we systematically analyzed the effect of various environmental signals on regulation of the biofilm phenotype, the c-di-gmp levels, and expression of hmst, hmsd, and hmsp in y. ...201627375563
[isolation and biological characteristics on yersinia pestis phage yp060].to isolate and identify the characteristics of yersinia pestis phage yp060 from mice nests in yunnan plague focus.201627346118
immunosuppressive yersinia effector yopm binds dead box helicase ddx3 to control ribosomal s6 kinase in the nucleus of host cells.yersinia outer protein m (yopm) is a crucial immunosuppressive effector of the plaque agent yersinia pestis and other pathogenic yersinia species. yopm enters the nucleus of host cells but neither the mechanisms governing its nucleocytoplasmic shuttling nor its intranuclear activities are known. here we identify the dead-box helicase 3 (ddx3) as a novel interaction partner of y. enterocolitica yopm and present the three-dimensional structure of a yopm:ddx3 complex. knockdown of ddx3 or inhibitio ...201627300509
effect of natural polymorphism on structure and function of the yersinia pestis outer membrane porin f (ompf protein): a computational study.the yersinia pestis outer membrane porin f (ompf) is a transmembrane protein located in the outer membrane of this gram-negative bacterium which is the causative agent of plague, where it plays a significant role in controlling the selective permeability of the membrane. the amino acid sequences of ompf proteins from 48 y. pestis strains representing all currently available phylogenetic groups of this gram-negative bacterium were recently deduced. comparison of these amino acid sequences reveale ...201627593697
a self-quenching-resistant carbon nanodot powder with multicolored solid-state fluorescence for ultra-fast staining of various representative bacterial species within one minute.in this study, we prepared self-quenching-resistant solid-state fluorescent carbon nanodots (sfcds) without any other solid matrices. the sfcds were prepared using a one-step microwave synthesis method through precise control of the heating power and time. the resulting sfcd powder showed excitation-dependent emission behavior with a maximum fluorescence quantum yield of 40%. the multicolored sfcds were successfully used as fluorescent agents for rapid staining of 14 representative bacterial spe ...201627874136
an update on the hazards and risks of forensic anthropology, part ii: field and laboratory considerations.this paper focuses on potential hazards and risks to forensic anthropologists while working in the field and laboratory in north america. much has changed since galloway and snodgrass published their seminal article addressing these issues. the increased number of forensic practitioners combined with new information about potential hazards calls for an updated review of these pathogens and chemicals. discussion of pathogen hazards (brucella, borrelia burgdorferi, yersinia pestis, clostridium tet ...201626389711
fast, sensitive point of care electrochemical molecular system for point mutation and select agent detection.point of care molecular diagnostics benefits from a portable battery-operated device capable of performing a fast turnaround using reliable inexpensive cartridges. we describe a prototype device for performing a molecular diagnostics test for clinical and biodefense samples in 16 minutes using a prototype capable of an 8 minute pcr reaction, followed by hybridization and detection on an electrochemical microarray based on the i-stat® system. we used human buccal swabs for hemochromatosis testing ...201627280174
an internal standard approach for homogeneous tr-fret immunoassays facilitates the detection of bacteria, biomarkers, and toxins in complex matrices.the recent development of a homogeneous time-resolved förster resonance energy transfer (tr-fret) immunoassay enables one-step, rapid (minutes), and direct detection compared to the multistep, time-consuming (hours), heterogeneous elisa-type immunoassays. the use of the time-resolved effect of a donor lanthanide complex with a delay time of microseconds and large stokes shift enables the separation of positive signals from the background autofluorescence of the sample. however, this study shows ...201627236318
a personal view of how paleomicrobiology aids our understanding of the role of lice in plague pandemics.we have been involved in the field of paleomicrobiology since 1998, when we used dental pulp to identify yersinia pestis as the causative agent of the great plague of marseille (1720). we recently designed a specific technique, "suicide pcr," that can prevent contamination. a controversy arose between two teams, with one claiming that dna must be altered to amplify it and the other group claiming that demographic data did not support the role of y. pestis in the black death (i.e., the great plag ...201627726806
molecular survey of bartonella species and yersinia pestis in rodent fleas (siphonaptera) from chihuahua, mexico.rodent fleas from northwestern chihuahua, mexico, were analyzed for the presence of bartonella and yersinia pestis. in total, 760 fleas belonging to 10 species were tested with multiplex polymerase chain reaction analysis targeting the glta (338-bp) and pla genes (478-bp) of bartonella and y. pestis, respectively. although none was positive for y. pestis, 307 fleas were infected with bartonella spp., resulting in an overall prevalence of 40.4%. a logistic regression analysis indicated that the p ...201626576933
novel engineered cationic antimicrobial peptides display broad-spectrum activity against francisella tularensis, yersinia pestis and burkholderia pseudomallei.broad-spectrum antimicrobials are needed to effectively treat patients infected in the event of a pandemic or intentional release of a pathogen prior to confirmation of the pathogen's identity. engineered cationic antimicrobial peptides (ecaps) display activity against a number of bacterial pathogens including multi-drug-resistant strains. two lead ecaps, wlbu2 and wr12, were compared with human cathelicidin (ll-37) against three highly pathogenic bacteria: francisella tularensis, yersinia pesti ...201626673248
a recombinant trivalent fusion protein f1-lcrv-hsp70(ii) augments humoral and cellular immune responses and imparts full protection against yersinia pestis.plague is one of the most dangerous infections in humans caused by yersinia pestis, a gram-negative bacterium. despite of an overwhelming research success, no ideal vaccine against plague is available yet. it is well established that f1/lcrv based vaccine requires a strong cellular immune response for complete protection against plague. in our earlier study, we demonstrated that hsp70(ii) of mycobacterium tuberculosis modulates the humoral and cellular immunity of f1/lcrv vaccine candidates indi ...201627458447
[pilot-scale purification of rf1-v fusion protein of yersinia pestis and characterization of its immunogenicity].recombinant fl-v (rfl-v) fusion protein is the main ingredient of the current candidate vaccine against yersinia pestis infection, which has been under investigation in clinical trial in usa. we investigated the soluble expression conditions of rf1-v in escherichia coli bl21 (de3) that we constructed before. after scale-up and optimization of fermentation processes, we got the optimized fermentation process parameters: the culture was induced at the middle exponential phase with 50 µmol/l of ipt ...201627363202
evolution and structural dynamics of bacterial glycan binding adhesins.infectious disease processes like bacterial adherence or the activity of secreted toxins frequently gain host and tissue specificity by glycan binding interactions with the host glycome. recent functional and structural studies highlight the high niche specialization of bacterial lectins, but also reveal a remarkable plasticity in their glycan binding sites and mechanisms, to adapt to host glycome dynamics or changing environmental conditions at the site of infection. in this review we put empha ...201628043017
pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents.the sulfonamide class of antibiotics has been in continuous use for over 70years. they are thought to act by directly inhibiting dihydropteroate synthase (dhps), and also acting as prodrugs that sequester pterin pools by forming dead end pterin-sulfonamide conjugates. in this study, eight pterin-sulfonamide conjugates were synthesized using a novel synthetic strategy and their biochemical and microbiological properties were investigated. the conjugates were shown to competitively inhibit dhps, a ...201627423480
highly effective soluble and bacteriophage t4 nanoparticle plague vaccines against yersinia pestis.plague caused by yersinia pestis is an ancient disease, responsible for millions of deaths in human history. unfortunately, there is no fda-approved vaccine available. recombinant subunit vaccines based on two major antigens, caf 1 (f1) and lcrv (v), have been under investigation and showed promise. however, there are two main problems associated with these vaccines. first, the yersinia capsular protein f1 has high propensity to aggregate, particularly when expressed in heterologous systems such ...201627076150
quaternary structure of fur proteins, a new subfamily of tetrameric proteins.the ferric uptake regulator (fur) belongs to the family of the dna-binding metal-responsive transcriptional regulators. fur is a global regulator found in all proteobacteria. it controls the transcription of a wide variety of genes involved in iron metabolism but also in oxidative stress or virulence factor synthesis. when bound to ferrous iron, fur can bind to specific dna sequences, called fur boxes. this binding triggers the repression or the activation of gene expression, depending on the re ...201626886069
the yersiniabactin-associated atp binding cassette proteins ybtp and ybtq enhance escherichia coli fitness during high-titer cystitis.the yersinia high-pathogenicity island (hpi) is common to multiple virulence strategies used by escherichia coli strains associated with urinary tract infection (uti). among the genes in this island are ybtp and ybtq, encoding distinctive atp binding cassette (abc) proteins associated with iron(iii)-yersiniabactin import in yersinia pestis in this study, we compared the impact of ybtpq on a model e. coli cystitis strain during in vitro culture and experimental murine infections. a ybtpq-null mut ...201626883590
reciprocal regulation of yersinia pestis biofilm formation and virulence by rovm and rova.rova is known to enhance yersinia pestis virulence by directly upregulating the psa loci. this work presents a complex gene regulatory paradigm involving the reciprocal regulatory action of rovm and rova on the expression of biofilm and virulence genes as well as on their own genes. rovm and rova enhance and inhibit y. pestis biofilm production, respectively, whereas rovm represses virulence in mice. rovm directly stimulates the transcription of hmst, hmscde and rovm, while indirectly enhancing ...201626984293
inhibition of pseudomonas aeruginosa exsa dna-binding activity by n-hydroxybenzimidazoles.the pseudomonas aeruginosa type iii secretion system (t3ss) is a primary virulence determinant and a potential target for antivirulence drugs. one candidate target is exsa, a member of the arac family of dna-binding proteins required for expression of the t3ss. a previous study identified small molecules based on an n-hydroxybenzimidazole scaffold that inhibit the dna-binding activity of several arac proteins, including exsa. in this study, we further characterized a panel of n-hydroxybenzimidaz ...201626574012
rapid antimicrobial susceptibility testing of bacillus anthracis, yersinia pestis, and burkholderia pseudomallei by use of laser light scattering technology.rapid methods to determine antimicrobial susceptibility would assist in the timely distribution of effective treatment or postexposure prophylaxis in the aftermath of the release of bacterial biothreat agents such as bacillus anthracis, yersinia pestis, or burkholderia pseudomallei conventional susceptibility tests require 16 to 48 h of incubation, depending on the bacterial species. we evaluated a method that is based on laser light scattering technology that measures cell density in real time. ...201626984973
genomic insights into a new citrobacter koseri strain revealed gene exchanges with the virulence-associated yersinia pestis ppcp1 plasmid.the history of infectious diseases raised the plague as one of the most devastating for human beings. far too often considered an ancient disease, the frequent resurgence of the plague has led to consider it as a reemerging disease in madagascar, algeria, libya, and congo. the genetic factors associated with the pathogenicity of yersinia pestis, the causative agent of the plague, involve the acquisition of the ppcp1 plasmid that promotes host invasion through the expression of the virulence fact ...201627014253
engineered nanoconstructs for the multiplexed and sensitive detection of high-risk pathogens.many countries categorize the causative agents of severe infectious diseases as high-risk pathogens. given their extreme infectivity and potential to be used as biological weapons, a rapid and sensitive method for detection of high-risk pathogens (e.g., bacillus anthracis, francisella tularensis, yersinia pestis, and vaccinia virus) is highly desirable. here, we report the construction of a novel detection platform comprising two units: (1) magnetic beads separately conjugated with multiple capt ...201626462853
genetic variation at the mhc drb1 locus is similar across gunnison's prairie dog (cynomys gunnisoni) colonies regardless of plague history.yersinia pestis was introduced to north america around 1900 and leads to nearly 100% mortality in prairie dog (cynomys spp.) colonies during epizootic events, which suggests this pathogen may exert a strong selective force. we characterized genetic diversity at an mhc class ii locus (drb1) in gunnison's prairie dog (c. gunnisoni) and quantified population genetic structure at the drb1 versus 12 microsatellite loci in three large arizona colonies. two colonies, seligman (se) and espee ranch (es), ...201627066243
nqrm (duf539) protein is required for maturation of bacterial na+-translocating nadh:quinone oxidoreductase.na(+)-translocating nadh:quinone oxidoreductase (na(+)-nqr) catalyzes electron transfer from nadh to ubiquinone in the bacterial respiratory chain, coupled with na(+) translocation across the membrane. na(+)-nqr maturation involves covalent attachment of flavin mononucleotide (fmn) residues, catalyzed by flavin transferase encoded by the nqr-associated apbe gene. analysis of complete bacterial genomes has revealed another putative gene (duf539, here renamed nqrm) that usually follows the apbe ge ...201626644436
detection of a yersinia pestis gene homologue in rodent samples.a homologue to a widely used genetic marker, pla, for yersinia pestis has been identified in tissue samples of two species of rat (rattus rattus and rattus norvegicus) and of mice (mus musculus and apodemus sylvaticus) using a microarray based platform to screen for zoonotic pathogens of interest. samples were from urban locations in the uk (liverpool) and canada (vancouver). the results indicate the presence of an unknown bacterium that shares a homologue for the pla gene of yersinia pestis, so ...201627602258
navigable rivers facilitated the spread and recurrence of plague in pre-industrial europe.infectious diseases have become a rising challenge to mankind in a globalizing world. yet, little is known about the inland transmission of infectious diseases in history. in this study, we based on the spatio-temporal information of 5559 plague (yersinia pestis) outbreaks in europe and its neighboring regions in ad1347-1760 to statistically examine the connection between navigable rivers and plague outbreak. our results showed that 95.5% of plague happened within 10 km proximity of navigable ri ...201627721393
crp is an activator of yersinia pestis biofilm formation that operates via a mechanism involving gmha and waaae-coad.gmha encodes a phosphoheptose isomerase that catalyzes the biosynthesis of heptose, a conserved component of lipopolysaccharide (lps). gmha plays an important role in yersinia pestis biofilm blockage in the flea gut. waaa, waae, and coad constitute a three-gene operon waaae-coad in y. pestis. waaa encodes a transferase that is responsible for binding lipid-a to the core oligosaccharide of lps. waaa is a key determinant in y. pestis biofilm formation, and the waaa expression is positively regulat ...201627014218
new role for fda-approved drugs in combating antibiotic-resistant bacteria.antibiotic resistance in medically relevant bacterial pathogens, coupled with a paucity of novel antimicrobial discoveries, represents a pressing global crisis. traditional drug discovery is an inefficient and costly process; however, systematic screening of food and drug administration (fda)-approved therapeutics for other indications in humans offers a rapid alternative approach. in this study, we screened a library of 780 fda-approved drugs to identify molecules that rendered raw 264.7 murine ...201627067323
how old are bacterial pathogens?only few molecular studies have addressed the age of bacterial pathogens that infected humans before the beginnings of medical bacteriology, but these have provided dramatic insights. the global genetic diversity of helicobacter pylori, which infects human stomachs, parallels that of its human host. the time to the most recent common ancestor (tmrca) of these bacteria approximates that of anatomically modern humans, i.e. at least 100 000 years, after calibrating the evolutionary divergence withi ...201627534956
biocidal and sporicidal efficacy of pathoster(®) 0.35% and pathoster(®) 0.50% against bacterial agents in potential bioterrorism use.the use of products that can neutralize or significantly reduce the microbial load and that are not harmful to human health and the environment represents a milestone in the fight against the spread of infectious diseases. peracetic acid, besides being an excellent sterilizing and sporicidal agent, is harmless to humans and the environment when it is used in a common dosage. however, the high costs and loss of efficacy of the product very quickly after its reconstitution limit its use. we evalua ...201627482880
targeted next-generation sequencing for the detection of ciprofloxacin resistance markers using molecular inversion probes.antibiotic resistance (ar) is an epidemic of increasing magnitude requiring rapid identification and profiling for appropriate and timely therapeutic measures and containment strategies. in this context, ciprofloxacin is part of the first-line of countermeasures against numerous high consequence bacteria. significant resistance can occur via single nucleotide polymorphisms (snp) and deletions within ciprofloxacin targeted genes. ideally, use of ciprofloxacin would be prefaced with ar determinati ...201627174456
development of liposomal ciprofloxacin to treat lung infections.except for management of pseudomonas aeruginosa (pa) in cystic fibrosis, there are no approved inhaled antibiotic treatments for any other diseases or for infections from other pathogenic microorganisms such as tuberculosis, non-tuberculous mycobacteria, fungal infections or potential inhaled biowarfare agents including francisella tularensis, yersinia pestis and coxiella burnetii (which cause pneumonic tularemia, plague and q fever, respectively). delivery of an antibiotic formulation via the i ...201626938551
[clinical diagnosis of congenital tricuspid valve atresia]. 20165091764
vasectomy. 20165067588
[proceedings: aseptic operating rooms]. 20164782308
[indications for and the outcome of pneumonectomy in the presence of destructive tuberculosis in the other lung]. 20164784039
urinary vaginal fistulae: a series of 152 patients treated in a small hospital in ghana. 20164807491
[hyperthyroidism in patients over 65 years]. 20164807483
[control of chagas' disease in the municipality of bariri, state of são paulo]. 20164990137
[multipurpose cuvette for immunodiffusion preparations]. 20164972960
[aging from a biological point of view]. 20165023128
the public health '72: the story behind the statistics. 20164756364
[hormonal activity of adrenal glands in patients with primary lesion of the hypothalamic region]. 20164756508
centennial of the founding of the alumni association of the jefferson medical college. 20164909105
acquired hemolytic anemia with features simulating hereditary spherocytosis and paroxysmal nocturnal hemoglobinuria in the same patient. 20165040114
arterial mesenchyme and arteriosclerosis. studies on the conformation and interaction of elastin. 20164836418
[conservative treatment of chronic arterial occlusive disease using trental]. 20165037492
clinical applications of brain blood flow studies. 20164938393
is very early ambulation safe in patients of acute myocardial infarction. 20164789730
nutrition education-or education in child care? 20164746245
treatment of melanoma by endolymphatic therapy. 20164821237
magnitude estimation of visual velocity. 20165053926
obturator hernia. 20165037804
[definition of life and death. 2]. 20164978820
[constitutional medicine from achille de giovanni (1838-1916) to giacinto viola (1870-1943)]. 20164927057
[fracture of the thumb sesamoid bone]. 20165026710
dichotomies in discovery. 20165068295
simplified technique for tubeless hypotonic duodenography. 20165015830
[lymphocytic transformation "in vitro" in hodgkin's disease and in sarcoidosis]. 20164965889
autoradiographic localization of 3 h- -ecdysone in salivary gland cells of drosophila virilis. 20164945007
[an attempt to prevent lymphoid atrophy in secondary disease of radiation chimeras by means of transplanting the lymphocytes of a recipient]. 20164914553
[plastic reconstruction of the frontal bone]. 20164905634
impressions for complete dentures. 20164898720
[test persons and control groups--psychological and epidemiological viewpoints]. 20164891359
[new dental equipment for denture base splint, omnivac 3]. 20164890686
public relations relies on the motion picture, "the double day of danny dillon". 20164888304
the problem of the manipulating patient. 20164845594
hypertensive retinopathy. a prospective hospital study of 100 hypertensive kenyan africans. 20164845025
long term treatment of chronic schizophrenia; a lack of controls. 20164862725
[electrotonography in retinal detachment]. 20164848639
freud in the american scene. 20164931627
[relevance of epidemiologic studies in enzymatic screening tests of patient collectives incubated with hepatitis]. 20164832552
[extracellular space and swelling in the central nervous system in vivo and in vitro]. 20164906001
[open perilunar dorsal dislocation]. 20164773443
[organization of work in pharmacies. i]. 20164775960
[dyskeratosis follicularis darier. studies in a family with 11 manifest patients in three from four generations]. 20164767418
clinical results with a new antifungal agent. 20164810614
some genetic traits in solomon island populations. 3. relative toe length. 20164750669
conditional diffusion processes in population genetics. 20164726007
pseudomyopia as a presenting sign in ocular myasthenia gravis. 20164706420
relationships between ocular dimensions and the effects of provocative tests. water drinking. homatropine eye drops. water drinking and homatropine eye drops. 20165097395
has the prevalence of coronary sclerosis and coronary heart disease increased? 20165090208
reptitive dna sequences in drosophila. 20165088497
[ldh isoenzymes in the serum in development control of tumor patients]. 20165093323
[geographic variation of bone sarcoma]. 20165037136
[darier-ferrand tumor]. 20164988056
who does what under material management. 20164786787
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