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slow infections with unconventional viruses. 1978108233
accumulation of iron by yersiniae.escherichia coli, bacillus megaterium, and three species of yersiniae grew rapidly without significant production of soluble siderophores in a defined iron-sufficient medium (20 microm fe3+). in iron-deficient medium (0.1 to 0.3 microm fe3+) all organisms showed reduced growth, and there was extensive production of siderophores by e. coli and b. megaterium. release of soluble siderophores by yersinia pestis, y. pseudotuberculosis, or y. enterocolitica in this medium was not detected. citrate (1 ...1979108243
pregnant mare serum gonadotropin. purification and physicochemical, biological, and immunological characterization. 1979108273
[effect of exogenous nucleodepolymerases on bacillus subtilis multiplication].the effect of exogenous nucleodepolymerases on cell growth was studied with bacillus subtilis. nucleodepolymerases of microbial and animal origin stimulated growth of the culture. the stimulating action of dnaases depended on the dose of the enzyme added to the growth medium and on the phase of the cultural growth. acceleration of the cultural growth correlated with intensification of dna synthesis in the bacterial cells.1979108529
[criteria of resistance of some antibiotics and chemotherapeutics for strains of mycobacterium tuberculosis isolated in czechoslovakia. cycloserin, ethionamide, pyrazinamide, rifampicin, and ethambutol (author's transl)]. 1979109213
pseudomonas aeruginosa vasculitis and bacteremia following conjunctivitis: a simple model of fatal pseudomonas infection in neutropenia.during attempts to create a realistic model of fatal bacteremia due to pseudomonas aeruginosa during immunosuppression, it was found that the invasive as well as the disseminated phase of infection could be mimicked by gentle instillation of 10(8) colony-forming units of p. aeruginosa into the intact conjunctival sac of agranulocytic rabbits. within 48 hr animals developed conjunctivits leading to severe necrotizing vasculitis and fatal bacteremia. twelve of 26 strains from patients with p. aeru ...1979109545
selective proteolysis of the beta 2 subunit of serratia marcescens tryptophan synthase. 1979110267
aminopeptidase i activities in several microorganisms.aminopeptidase i activity which was found to be localized in the same subcellular fraction and to be similarly heat stable was partially purified by a common procedure from escherichia coli b, escherichia coli k12, enterobacter aerogenes, salmonella typhimurium, serratia marcescens pseudomonas aeruginosa, and proteus vulgaris. the enzyme preparations were shown to contain a single animopeptidase active toward both leucylleucine and methionylalanylserine by mixed-substrate initial-velocity kineti ...1978110425
response of various cell lines to escherichia coli toxic products.seven cell lines were compared with y-1 and vero cells for morphological response to e. coli toxic products. fl and wi-38, like y-1 and vero, responded to heat-labile enterotoxin. fl, hep-2, hela, and bgm, like vero but not y-1, responded to heat-labile cytotoxin. fl was comparable to vero in sensitivity to these two toxic products.1979110431
a new principle of injectable depot contraceptives. i drug selection and studies in monkeys.the aim of the investigations was to develop a long-acting depot contraceptive on the basis of norethisterone or levonorgestrel. disappointing results with levonorgestrel nonanoate and levonorgestrel undecylate showed that elongation of the fatty acid, esterified with the steroid, decreased the bioavailability of the latter due to incomplete hydrolysis of the ester. therefore, several new compounds were synthesized which contained a bifunctional molecule between the steroid and the fatty acid. i ...1979110513
lysosomal beta-d-galactosidase in man-hamster somatic cell hybrids. 1978110521
the preparation and characterization of different types of light-harvesting pigment-protein complexes from some purple bacteria.a general strategy, with some specific examples, is given for the isolation and purification of detergent-soluble, antenna pigment-protein complexes from the photosynthetic membranes. absorption, fluorescence and circular dichroism spectra, and the pigment and protein composition of b800-b850-protein and b890-protein complexes of some purple bacteria (rhodospirillum rubrum, rhodopseudomonas sphaeroides and rps. capsulata and chromatium vinosum) are discussed. we conclude that there are probably ...1978110568
chronic administration of chenodeoxycholic acid increases cholesterol saturation in bile in the dog.six dogs were given chenodeoxycholic acid, 200 mg/day for 15 days; gallbladder and hepatic bile samples were taken and biliary bile acids, phospholipids and cholesterol were compared to those of fourteen control dogs. it was found that: (1) the cholesterol saturation index of gallbladder bile was higher in treated dogs (0.12 +/- 0.06; m +/- sd) than in controls (0.07 +/- 0.01; p less than 0.05); the proportion of chenodeoxycholic acid in gallbladder bile was higher in treated dogs (27.8 +/- 12.5 ...1979110595
[melanin-producing strains of pseudomonas aeruginosa]. 1979111005
effect of neonatal hypothyroidism and delayed l-triiodothyronine treatment on behavioural activity and norepinephrine and dopamine biosynthetic systems in discrete regions of rat brain. 1979111295
gram-negative germs infections in infancy.the incidence of systemic or local infections due to gram-negative bacilli in an infant ward from september 1969 to december 1976 was 7.9%. the 29.34% were septicemia, most of them as epidemic outbreaks caused by pseudomonas aeruginosa, klebsiella-enterobacter and serratia marcescens. two facts are to be emphasized: an almost complete disappearance of systemic infections with pseudomonas starting from 1972, and the global predominance of the group klebsiella-enterobacter, particularly evident fr ...1979112565
antibacterial activity of a new parenteral cephalosporin--hr 756: comparison with cefamandole and ceforanide.hr 756, a new parenteral cephalosporin that is beta-lactamase resistant, was tested against 271 bacterial isolates. both agar and broth dilution testing were employed, using two media and two inoculum sizes of bacteria. antibacterial activity of the drug was compared to that of cefamandole (cfm) and ceforanide (cfn). in agar, hr 756 was more active than cfm and cfn against all bacteria tested except isolates of staphylococcus aureus, which were better inhibited by cfm. hr 756 exhibited some anti ...1979112919
[involvement of mycoplasma ovipneumoniae in enzootic proliferating interstitial pneumonia in sheep]. 1979113871
infective endocarditis in the narcotic addict.as long as the illicit use of heroin and other drugs continues in our society, infective endocarditis will remain a significant medical problem in the drug-using population. the majority of infections are produced by s. aureus, and the tricuspid valve is most commonly involved. addicts, unlike the general population, may also develop endocarditis with a variety of gram-negative bacilli and have a higher incidence of fungal infection. the outcome of each individual infection is dependent on the p ...1979116317
[examinations on the behaviour of grampositive and gramnegative bacteria on aluminium foil (author's transl)].the survival times of staph. aureus, strept. faecalis, e. coli, klebs. pneumoniae, ser. marcescens and p. aeruginosa were found out on aluminium foil. it was examined whether there exists a dependence on the initial colony count and in mixed cultures a mutual influence of the several species of bacteria. the longest survival times were found among the grampositive cocci. ser. marcescens and klebs. pneumoniae could no more be indicated after 19 days in case of initial colony count of log 7.0/cm2; ...1979116442
renal malakoplakia with renal vein thrombosis. 1979116513
cost-benefit studies of vaccinations in finland.the benefits of vaccination are, in general, recognized. for some diseases these benefits are obvious. when starting or evaluating new vaccination programmes, a more critical approach is needed. before starting vaccination against measles and rubella in finland a cost-benefit study was performed. according to those studies the net benefits of each vaccination would be ca. 100 million finnish marks in 25-30 years. those benefits not measurable in money value of human life, decrease of suffering, ...1979118069
irgasan-induced pigmentation in serratia marcescens and pseudomonas aeruginosa.two irgasan-resistant micro-organisms (p. aeruginosa and s. marcescens) were used to study the effects of various antibiotic and chemotherapeutic agents on pigment production. these agents included streptomycin, thallium acetate, polymyxin b, hexachlorophene, irgasan, prodigiosin and dmso (dimethyl sulphoxide). only irgasan, compared to other drugs and membrane-active agents showed the unique property of inducing pigmentation in both p. aeruginosa and s. marcescens, i.e. prodigiosin in s. marces ...1979119134
mutational mosaicism and genetic counseling in retinoblastoma.mutations may arise throughout an organism's life cycle. typically, sporadic meiotic mutations give rise to individuals with all their germinal and somatic cells bearing the mutant gene. these mutations may be amorphs (with full penetrance and expressivity) or hypomorphs (with reduced penetrance and expressivity). mutational mosaicism, however, involves the origin of mutations occurring during mitosis, whether in the parent at some stage prior to reproductive maturity or in the offspring at some ...1979120116
[effect of enkephalin and morphine on gastric secretion and gastric blood flow]. 1979120296
the effect of lampit on trypanosoma cruzi in mice organs and in the bloodstream.mice infected with bloodstream forms of trypanosoma cruzi were treated with an active nitrofuran compound (nifurtimox, lampit). determination of the number of intracellular forms of t. cruzi in the liver and the spleen of control and lampit-treated mice showed that the drug induced a decrease in the number of parasites inside the cells. a decrease in the number of bloodstream forms was also observed. ultrastructural observations showed that lampit induces several alterations in t. cruzi, the mos ...1979120645
[examinations about the mutual influence of bacteria in aqueous medium with minimal nutritive substances (author's transl)].experiments were done about the behaviour of 5 different strains of st. aureus (= st), e. coli (= ec), se. marcescens (= se) and p. aeruginosa (= pa) in aqua bidest. at 30 degress c and 40 degrees c. in the first part the smallest quantities of standard-i-broth (merck) were evaluated where the diverse bacteria-species are able to grow; it was found at 30 degrees c (in parenthesis at 40 degrees c): st. aureus 1750 (3750) microgram/dl, e. coli 1000 (1750) microgram/dl, se. marcescens 2.5 (125) mic ...1979120653
[examinations on the behaviour of grampositive and gramnegative bacteria in aqua bidest and tap-water at different initial colony counts and different temperatures (author's transl)].experiments were done about the behaviour of 5 different strains of staph. aureus, strept. faecalis, e. coli, ser. marcescens and p. aeruginosa in aqua bidest and sterile tap water at 20 degrees c, 30 degrees c and 40 degrees c. the behaviour of 3 different initial colony counts in each case was examined. colony forming units (cfu) were evaluated at the beginning and after 1, 2, 4, 6 and 24 h. cfu were reduced at staph. aureus and e. coli in aqua bidest and tap water not earlier than after 4 h, ...1979120654
[vitamin d and reproduction in wistar rats].females have received from weaning a semi-synthetic diet (0,35% ca; 0,32% p; 0,03% mg), with or without vitamin d (+/- d). fertility of these females was not changed. at weaning, the young from mothers--d had lower weight, calcemia and phosphatemia, but the ash content of the femur was the same as for young from mothers + d. young rats from mothers +/- d were given the diet with or without vitamin d. 19 days after weaning, the diet of the mother (+/- d) appears to be the principal factor for gr ...1979120790
a preliminary report on the use of a chronic peritoneal fistula for endoscopic examination of ovine ovarian activity.a description is given of a technique devised to allow repeated endoscopic observations to be made of ovarian changes occurring during an oestrus cycle in the ewe. the use of a chronic peritoneal fistula is illustrated and the methods used to maintain its patency discussed. the technique was carried out in a small number of ewes and the ovarian changes occurring in an ovary of one of these ewes, over a 22 day period, are shown in photographic and diagrammatic form.1975123105
inhibitory effect of normal mammalian sera on the rosette formation of human lymphocytes with sheep red blood cells. 1975123840
experimental infection of dacron and bovine grafts. 1975124366
protein complementation. 1975124547
the mutagenicity of azathioprine in mice, drosophila melanogaster and neurospora crassa.the chemotherapeutic coumpound azathioprine was tested for possible mutagenicity in swiss albino mice, drosophila melanogaster and neurospora crassa. utilizing the dominant-lethal assay it was found that acute oral doses of azathioprine (2 times 25 mg/kg body weight), induced dominant-lethal mutations in mouse spermatocytes. chronic oral doses of azathioprine (2 times 25 mg/kg body weight/week for 10 weeks) resulted in a greater rate of dominant-lethality. this increase was not permanent, and by ...1975124817
functional polarity of the rat hepatocyte surface membrane. isolation and characterization of plasma-membrane subfractions from the blood-sinusoidal, bile-canalicular and contiguous surfaces of the hepatocyte.1. six rat liver plasma-membrane subfractions of different density and morphological, enzymic and chemical properties were prepared from homogenates by a combination of differential, rate-zonal and density-gradient centrifugation. they consisted of three vesicular 'light' subfractions of density 1.12-1.13 and three 'heavy' subfractions of density 1.16-1.18 containing membrane strips and intercellular junctions. 2. all six subfractions contained a basal adenylate cyclase activity. one of the 'lig ...1975125584
a study of the binding of adenosine diphosphate to myosin subfragment-1.the binding of adp to subfragment-1 was investigated by the gel filtration method. the amount of bound adp was determined as a function of free adp concentration. linear scatchard plots were obtained. the maximum binding number, 0.55 mole of adp per 10(5) g of protein, and the dissociation constant, 1.6 x 10(-6) m, were obtained, using subfragment-1 prepared by tryptic digestion, in the presence of 0.083 m kcl-10 mm mgcl2-0.02 m tris-hcl (ph 8), at 25 degrees. similar maximum numbers, about 0.5 ...1975125750
[observations on the combination of iga-deficiency and extremely low antibody titers against measles (author's transl)]. 1975126541
use of limulus assay to compare the biological activity of peptidoglycan and endotoxin.the gelation of a lysate prepared from the amebocytes of limulus polyphemus, the horseshoe crab, has been used to detect endotoxin-like material in clinical studies and in "in vitro" experiments. the investigation of blood samples from 54 hospitalized patients suspected of having endotoxemia, revealed a positive limulus test in 14. infections due to gram-positive organisms were not associated with positive assays. these results were in agreement with the observation that living gram-positive mic ...1975126558
amino-acid sequence of the cyanogen-bromide fragment from human plasminogen that forms the linkage between the plasmin chains.the complete amino acid sequence of a cyanogen bromide fragment (122 residues) obtained from plasminogen is described. this fragment forms the overlap between heavy (a) and light (b) chains of human plasmin. the particular arginyl-valyl bond cleaved in the second step of the activation process is shown to be arg98-val99 in this fragment. this site is not very similar to the one in the nh2-terminal part of the molecule (arg68-met69). remarkable homologies with the 'triple loops' ('kringle structu ...1975126863
an ultrastructural study of neuromuscular spindles in normal mice: with reference to mice and man infected with mycobacterium leprae.mycobacterium leprae have been found within muscle spindles in mice, using electron microscopy, and in man, using light microscopy. their mode of entry clearly is important. it may be via capsular cells, capillaries or nerves. for this reason muscle spindles from normal mice were studied by electron microscopy with special reference to the capsule and the relationship of it with capillaries and nerves, as well as details of the intrafusal fibres and capsular space. a fenestrated capillary was fo ...1975126981
characterization of 5.8s ribosomal ribonucleic acid in neurospora crassa.neurospora crassa ribosomes contain a species of ribonucleic acid (rna) of molecular weight 54,000, similar to 5.8s ribosomal rna previously described for other eukaryotic organisms. the 5.8s rna from n. crassa was found to be released by heat treatment at 60 c from 25s ribosomal rna but not from 18s ribosomal rna. the base composition of n. crassa 5.8s rna was similar to that of 5.8s rna from saccharomyces cerevisiae, but differed from animal 5.8s rna. during the course of this study, it was di ...1975126993
purification and properties of membrane-bound coupling factor-latent atpase from mycobacterium phlei.the membrane bound coupling factor-latent atpase was solubilized from the membrane vesicles of mycobacterium phlei by using 0.25 m sucrose or low ionic strength buffer. purification of the solubilized enzyme by use of sepharose-adp conjugate gel yielded a homogenous preparation of latent atpase which was purified about 216-fold in a single step with an 84% yield. the enzyme exhibits a specific activity of 39 mumoles of atp hydrolyzed per min per mg protein. the purified enzyme exhibits coupling ...1975127086
proteoglycans of soluble fraction of mouse mastocytoma.proteoglycans have been isolated from a high speed supernatant fraction of a mouse mastocytoma by procedures which should minimize alteration of the native protein-polysaccharide molecule. the methods used include in vivo labeling proteoglycans with 35s-sulfate, 3h-leucine and 3h-lysine, centrifugation of the tumor homogenate at 105,000 g, cetylpyridinium fractionation of the supernatant, and further purification of some of the fractions obtained by deae-cellulose column chromatography, gel filt ...1975127169
carbon-13 nuclear magnetic resonance study of chondroitin 4-sulfate in the proteoglycan of bovine nasal cartilage.the fourier transform 13c nuclear magnetic resonance spectra of bovine nasal cartilage proteoglycan subunit and complex and whole bovine nasal cartilage were obtained and compared with that of chondroitin 4-sulfate. the spectrum of chondroitin 4-sulfate in solution revealed multiple resolvable resonances with linewidths that are consistent with considerable segmental motion in the polysaccharide chain. the spectra of proteoglycan subunit and complex in solution and that of whole cartilage were v ...1975127176
[experiments and theoretical cell kinetic calculations on the problem of in vivo synchronization with vincristine in l 1210 ascites tumor cells and crypt cells of the mouse (author's transl)].experiments are described on synchronizing l 1210 ascites tumor cells and jejunal crypt cells of the mouse with vincristine. in both cases the percentage of mitoses increases to a peak value 4 hrs after application of vincristine and decreases during the following 8 hrs ("releasing time") to the level of the normal mitotic index. following this first mitotic peak no futher peak of neither the mitotic nor the labeling index was observed during 48 hrs in l 1210 ascites tumor cells and during 38 hr ...1975127443
reaction of yeast phosphofructokinase with succinic and maleic anhydride.modification of yeast phosphofructokinase by succinic and maleic anhydride influences the catalytic activity and the allosteric behaviour of the enzyme. depending on the degree of succinylation and maleinylation a decrease of maximum activity, an increase of the apparent affinity for fructose-6-phosphate, a decrease of the hill-coefficient and a diminution of atp-inhibition are observed. up to about 40% of the lysyl residues could be succinylated without dissociation of the hexameric protein, ho ...1975127493
the degradation of duplex dna by the recbc dnase of escherichia coli. 1975127577
mechanisms by which li+ stimulates the (na+ and k+)-dependent atpase.the addition of licl stimulated the (na+ + k+)-dependent atpase activity of a rat brain enzyme preparation. stimulation was greatest in high na+/low k+ media and at low mg-atp concentrations. apparent affinities for li+ were estimated at the alpha-sites (moderate-affinity sites for k+ demonstrable in terms of activation of the associated k+-dependent phosphatase reaction), at the beta-sites (high-affinity sites for k+ demonstrable in terms of activation of the overall atpase reaction), and at th ...1975127624
effect of essential phospholipids on the properties of atpases of isolated rat liver plasma membranes of young and old animals."essential" phospholipids (epl), rich in dilinoleyl-phosphatidylcholine were given orally to young and 780-800 day-old rats. the double-labelled (14c/32p) dilinoleyl-phosphatidylcholine was incorporated in plasma membranes and the amounts incorporated into different organs investigated. old animals incorporated higher radioactivity than young. the 14c/32p ratio however decreased in comparison with the substance administered. the amount of (na+-k+)-atpase in rat liver plasma membranes of old anim ...1975127894
inhibition of atp synthesis associated with 6-aminonicotinamide (6-an) teratogenesis in rat embryos.pregnant rats were injected ip with 6 mg/kg 6-aminonicotinamide (6-an) at day 12 of gestation. embryos removed between 1 and 48 h later had reduced adenosine triphosphate (atp) concentrations, of about 50% of control values. all fetuses examined near term were malformed. nicotinamide (nam, 100 mg/kg) given ip 1 h after 6-an afforded protection: malformations occurred in only 15% of the survivors; and there was minimal atp reduction, 15% below control values. nam given 2 and 4 h after 6-an produc ...1975128147
[some properties of preparations of na+ and k+-atpase treated with deoxycholate].the treatment of membrane suspension from the guinea pig kidney cortex possessing na+, + k+ -atpase activity with 0.20% sodium deoxycholate (dox : protein equals 12 : 1) leads to lowering of their enzymatic activity. dox-treated preparation can be divided into two fractions by centrigugation (1 hr - 22 000 g). the pellet has 1.5-fold higher enzymatic activity than the initial preparation and cannot be activated by small amounts of histones. the supernatant has 2-fold lower enzymatic activity tha ...1975128167
[genetic bases for the selection of microorganisms using analogs].the main mechanisms are considered for biosynthesis processes regulation by means of repression and inhibition with final products. on the basis of these mechanisms the state and prospects of the directed alteration of various stages in regulating the synthesis of primary and secondary metabolites, using breeding selection of mutants resistant to analogues are discussed. the main regularities are presented for using analogues of primary metabolites in the breeding strains with overproduction of ...1975128859
effect of potassium cardioplegia and hypothermia on left ventricular function in hypertrophied and nonhypertrophied hearts. 1975129876
[veterinary-sanitary measures on turkey farms]. 1975129930
[g. f. lang - prominent soviet scientist, clinician and public man (on the centenary of his birth)]. 1975130732
studies on in vitro carcinogenesis. i. autoradiographic and biochemical study on the incorporation of labelled methylcholantrene into mouse embryonic cells.the incorporation of radioactive labelled methylcholanthrene into cba/t6t6 mouse embryonic fibroblast cultures was studied by using light and electronmicroscopic autoradiographic and also liquid scintillation counting techniques. during 24 hrs treatment time at the applied methylcholanthrene concentrations (0.01-2.5 mug/ml) the proportion of cells labelled with 3h-methylcholanthrene and the number of grains above the cells showed a relationship with the duration of treatment and also with the do ...1976130740
treponemal antigen in immunopathogenesis of syphilitic glomerulonephritis.a patient with syphilitic glomerulonephritis had a renal biopsy and was treated for secondary syphilis. light, electron, and immunofluorescence microscopic studies revealed an acute proliferative glomerulonephritis with subepithelial, intramembranous, and subendothelial immune complex deposits containing igg, iga, igm, c4, and c3. similar local deposits containing predominantly igm were noted in areas of mesangial proliferation. indirect fluorescent antibody studies employing rabbit treponemal a ...1976130804
[turnover of free adenine nucleotides of the isolated and perfused rabbit heart].the turnover of free adenine nucleotides was studied in the perfused rabbit heart by the decline in radioactivity 3 h 30 after administration of a single pulse of tritiated adenine. the radioactivity of the perfusate was followed during the experiments. about 7% of the labelled adenine nucleotides were renewed by hour and 1,5% of the radioactivity was lossed by hour in the perfusion fluid.1976134762
biochemical variations in the matrix of human tendons in relation to age and pathological conditions.with increasing age, the human tendon shows an increase of collagen and a diminution of mucopolysaccharides and glycoproteins. similar findings have recently been reported by other authors in the tendons of mammals. fragments of tendon affected by tendinosis, obtained dlring suture and tenoplasty operations, were also examined. marked diminution of collagen and an increase of acid mucopolysaccharides and structural glycoproteins were found as compared with the control tendon.1975134980
histoenzymology of the lung. i. enzyme activities of the lung tissue of acult humans; relationships between structure and functions.human adult lung fragments removed from macroscopically undamaged and anthracosis exempted zones of lungs of 20 pneumonectomies made for cancer, were tested for 25 enzymic activities. the location and intensities of these enzymic activities were different in the lung tissue components; the bronchial epithelia contained highly active ldh, mdh, sdh, nadh-tr and nadph-tr, glucose-6-phosphate dehydrogenase, active hydroxyproline-2-epimerase, alkaline phosphatase. ca2+-activated atp-ase, and beta-gal ...1977140314
pathway for isoleucine formation form pyruvate by leucine biosynthetic enzymes in leucine-accumulating isoleucine revertants of serratia marcescens.leaky revertants isolated from isoleucine auxotrophs of serratia marcescens mutant resistant to alpha-aminobutyric acid were previously reported to accumulate leucine in the medium, due to the absence of both feedback inhibition and repression of leucine biosynthesis. growth of the revertant was accelerated by pyruvate, d(-)-citramalate, citraconate, and alpha-ketobutyrate, but not by threonine. extracts of the revertant exhibited high activities of pyruvate-dependent coenzyme a liberation from ...1977142769
acid mucopolysaccharides in metal-induced tumor and connective tissue capsules surrounding implants in rats. 1975142824
actual status of mutageneity testing with the host-mediated assay. 1977143925
cardiac hypertrophy and antihypertensive therapy.biochemical (myocardial dna, rna, and hydroxyproline) and humoral (plasma [pra] and kidney [kra] renin activity) factors were determined in spontaneously hypertensive rats (shr) and normotensive wistar controls (nr) before and following treatment with minoxidil or propranolol. minoxidil (150 mg.litre-1 drinking water) effectively controlled blood pressure (17.3 kpa vs 24.9 kpa [130 mmhg vs 187 mmhg], p less than 0.001) despite marked and sustained increases in both pra and kra ventricular weight ...1977145319
increased plasma prolactin levels induced in rats by d-fenfluramine: relation to central serotonergic stimulation.d-fenfluramine (7.5 and 10 mg/kg i.p.) and quipazine (10 and 20 mg/kg i.p.) increased plasma prolactin levels in male rats. metergoline (3 mg/kg p.o.) or p-chlorophenylalanine (100 mg/kg x 3, orally) pretreatment markedly blocked the prolactin-releasing effect of both d-fenfluramine and quipazine. this result suggests that the effect of these drugs on prolactin secretion could be mediated through a serotonergic mechanism. brain serotonin may thus exert a stimulatory role on prolactin secretion i ...1978149011
suppression of allosensitization in vitro by cells from tolerant rats.lymph node cells from avn rats tolerant to lew antigens after neonatal induction of tolerance, which did not react in the mixed lymphocyte culture and cytotoxicity assays, were tested for the presence of suppressor cells. sensitization of lymphocytes from normal rats was inhibited by the addition of lymph node cells from these tolerant rats. the mixed lymphocyte culture reaction of lymph node cells from normal avn rats with the irradiated lew cells was inhibited when lymphocytes from tolerant ra ...1978149029
[formation and persistence of antibodies against antigens of influenza virus envelope after natural infection (author's transl)]. 1978149605
occupational allergic contact dermatitis to virginiamycin, an antibiotic used as a food additive for pigs and poultry.a warehouseman aged 31 working in a pharmaceutical factory got an occupational contact dermatitis to virginiamycin (factor m), an antibiotic used as a food additive for pigs and poultry. a review is made of contact dermatitis to virginiamycin and to pristinamycin.1978149638
specific immunoprecipitation of atpase from escherichia coli. 1978149674
immunoglobulin and complement deposits in the lungs of new zealand black/white mice.forty-four new zealand black/white (nzb/w) f1 hybrid mice were studied for evidence of immune complex deposition in the lungs and kidneys. positive immunofluorescence was seen in the lungs of 27 mice. the pattern of lung fluorescence was granular in association with capillary walls in 16 mice and intracellular in 12. the incidence of granular fluorescence was increased with age and was seen in 80% of the lungs of mice over 13 months old. there was a correlation between capillary wall fluorescenc ...1978150120
biocompatibility tests of components of an implantable cardiac assist device.a permanently implantable in-series left ventricular assist device, the dynamic aortic patch (dap), has been tested in chronic animal experiments. the dap replaces a section of the intrathoracic aortic wall. hemothorax and hematocele at the implantation site have been complications in recent experiments. primary postoperative hemorrhage was ruled out, and the biocompatibility of all components was therefore examined. dacron velour, teflon felt, conductive polyurethane, segmented polyether polyur ...1978151687
immunological methods employed in an attempt to induce erythema nodosum leprosum (enl) in mice.in the mouse foot pad model five different parameters were employed to simulate the condition of enl as observed in the human. the experimental groups with five to six months leprosy infection were injected intravenously with various anti-mycobacterial antibodies, m. leprae sonicate and 'b' cells obtained from syngenic donors. the control group of animals, infected similarly, were treated either with m. leprae sonicate or gamma globulins precipitated from normal human serum. all recipients were ...1978151764
enzyme patterns in single human muscle fibers. 1978152314
irs, hew threaten triple-a bonds. 1978152403
effects of sarcoplasmic reticulum ca2+-atpase on phospholipid bilayer fluidity: boundary lipid. 1978153147
spinal subdural empyema: report of two cases.spinal subdural empyema (sse) is a rare variety of intraspinal infection. sse should be suspected in patients presenting with fever, back pain, and signs of cord or nerve root compression. two patients with sse are presented. the first patient complained of fever and back pain. she had no neurological deficit but was found to have sse. the second patient, who presented with intracerebral hemorrhage in the fifth month of pregnancy and spontaneous abortion, was found to have sse at lumbar puncture ...1978154072
high-temperature inactivation of passive potassium transport in electrically non-excitable cells.high-temperature inactivation of passive potassium transport is demonstrated for mouse cell cultures and discussed in analogy to recent results on model systems from phospholipid/cholesterol doted with channel-forming antibiotics.1978154230
[clinical and experimental animal studies made to evaluate silastic and feeeze dried dura used in the treatment of orbital floor fractures (author's transl)].a comparison has been made of the results obtained using silastic and freeze-dried dura in experiments on dogs treated for orbital floor fractures. dura was found to be a better implant than silastic because the former material will be completely resorbed and replaced by cicatricial connective tissue. silastic tends to remain in its original site or position and may lead to secondary injuries because of its mobility. accordingly, the latter material is indicated for use in the case of extensive ...1978154257
molecular transformations in sarcoplasmic reticulum of fast-twitch muscle by electro-stimulation.chronic electro-stimulation of fast-twitch rabbit muscle with the frequency pattern received by a slow-twitch muscle induces a progressive transformation of the sarcoplasmic reticulum. after 2 days stimulation activities of ca2+-dependent atpase and of ca2+ transport begin to decrease, and are paralleled by a progressive decrease in ca2+-dependent and ca2+, mg2+-dependent phosphoprotein formation, reduced rate of dephosphorylation and a rearrangement of the electrophoretic polypeptide and phosph ...1979154404
[morphology of the radiation changes in the jaw bones under the experimental effect of calcitonin]. 1979154602
the detection of neoantigenic sites on the d-dimer peptide isolated from plasmin digested cross linked fibrin. 1979154752
electron microscopy of synaptonemal complexes in semithin sections.the technique of osmium tetroxide fixation followed by a treatment with p-phenylenediamine was applied to mouse testes in order to analyze pachytene nuclei. observation of epon semithin sections (0.25--0.5 micrometer) in conventional electron microscopy revealed the presence of positively stained synaptonemal complexes surrounded by unstained chromatin. the present results show that by using this method a suitable contrast and resolution can be achieved for semithin sections, which facilitates t ...1979156471
suppressor t cells regulate the cytolytic t lymphocyte response to syngeneic tumors induced by murine sarcoma virus (msv) in the mouse.studies were designed to analyze the immune activities of spleen cells from mice previously injected with murine sarcoma virus (msv) and undergoing the processes of msv tumor growth and rejection. fractionation of msv-primed spleen cells according to cell size by velocity sedimentation at unit gravity showed that msv-specific cytolytic t lymphocytes (ctl) generated in vivo underwent an apparent transition in size from large to small cells as the tumor regressed. the majority of ctl precursors, h ...1979156765
deoxyribonucleic acid sequence homologies among bacterial insertion sequence elements and genomes of various organisms.plasmid and phage deoxyribonucleic acid (dna) harboring bacterial insertion sequence (is) elements is1, is2, and is5 were characterized and used as probes to detect homologous sequences in various procaryotic and eucaryotic genomes. the hybridization method used permits the detection of sequences partially homologous to the elements. hybridization of the is-containing probes to each other revealed a region of limited homology between is1 and is2. homologous sequences were then detected by comput ...1979159291
[distribution of bdellovibrio bacteriovorus parasitizing pseudomonas fluorescens and serratia marcescens in river water]. 1979160878
[serratia marcescens (author's transl)]. 1979161519
aplastic anemia: evidence of immuno-pathomechanisms and successful treatment with absorbed atg. 1979161537
[autoradiographic studies on protein metabolism and histochemical demonstration of the brain zinc content in diabetes mellitus. 1. comparison in experimental streptozotocin-induced diabetes].by application of streptozotocin diabetes mellitus is induced in rats: 40 mg/kg body weight streptozotocin produce a fairly serious diabetes with minimal ketosis, 125 mg/kg body weight streptozotocin cause a severe diabetic keto-acidosis. after 72 hours these animals and also a group of control animals receive 8.33 mci/animal 3h-leucine intraperitoneally. by means of stripping film autoradiograms the rates of uptake of 3h-leucine in different areas of the rat brain are measured. the values of th ...1979161876
[viral respiratory infections]. 1975162793
the transport of triglyceride in the high-density lipoproteins of human plasma.the metabolism of the small pool of triglyceride in human high-density lipoproteins (hdl) has been studied. in 28 postabsorptive and unmedicated subjects the previously reported reciprocal relationships between the concentration of very low-density lipoprotein (vldl) lipids and hdl cholesterol was confirmed. it was also found that the hdl triglyceride correlated positively and significantly with the concentration of vldl triglyceride, and there was a significant negative correlation between the ...1975163284
uptake of 3-o-methyl-d-glucose into cultured human glioma cells. 1975163292
feedback regulation of 25-hydroxycholecalciferol metabolism by vitamin d3.1. in vitamin d-deficient chicks both vitamin d3 and 1alpha-hydroxycholecalciferol markedly decrease renal 1-hydroxylase activity and induce 24-hydroxylase activity. 2. actinomycin d abolishes both effects. 3. these results are consistent with feedback regulation of vitamin d3 metabolism by a direct nuclear action of the vitamin or its metabolites on the kidney cells.1975163720
regulation of human chorionic gonadotropin (hcg) secretion by serum and dibutyryl cyclic amp in malignant trophoblast cells in vitro.human chorionic gonadotropin (hcg) secretion was studied in human malignant trophoblast cells (jar line) in continuous culture. radioimmunoassayable hcg in the cells and in the daily culture fluid was increased for at least 3 days by 10% newborn calf serum and by 1 mn n-6, 0-2'-dibutyryl cyclic adenosine 3', 5'-monophosphoric acid (dbcamp) plus 1 mm theorphylline. incubation of the cells in the presence of serum, dbcamp and theorphylline resulted in additive stimulation of hcg secretion after 1 ...1975163842
protein deficiency in carbon tetrachloride-induced hepatic lesions.the influence of protein deficiency on the hepatotoxicity of carbon tetrachloride (ccl4) was investigated in a group of rhesus monkeys. animals fed a protein-rich diet served as controls. the results indicate that protein-deficiency protects the liver against acute hepatotoxicity of this drug. the protective effect is abolished if the animals are administered phenobarbital prior to the administration of ccl4. the protective action is due to a reduction, in protein deficiency, of the endoplas ...1975164171
the biogenesis of mitochondrial membranes in the yeast saccharomyces cerevisiae.membrane lipids of yeast mitochondria have been enriched by growing yeast cells in minimal medium supplemented with specific unsaturated fatty acids as the sole lipid supplement. using the activity of marker enzymes for the outer (kynurenine hydroxylase) and inner (cytochrome c oxidase and oligomycin-sensitive atpase) mitochondrial membranes, arrhenius plots have been constructed using both promitochondria and mitochondria obtained from o2-adapting cells in the presence of a second unsaturated f ...1975164216
[antigenic characteristics of hamster cells transformed by polyoma virus].a hamster cell line derived from a polyoma virus induced tumour (g-py) was found positive for tsta and s antigen detected by the surface immunofluorescence technique. lung metastases were observed in some hamster able to reject a g-py cell challenge dose injected by intradermal route.1975164877
cyclic adenosine 3':5'-monophosphate and inhibition of deoxyribonucleic acid synthesis in vitro.results are presented which suggest that inhibition of tritiated thymidine incorporation into the deoxyribonucleic acid of bone marrow in vitro by high concentrations of cyclic adenosine 3':5'-monophosphate is pharmacological in nature, and thus apparently unrelated to the physiological actions of camp.1975165140
hydrophobic interactions of the apo-gln-i polypeptide component of human high density serum lipoprotein.apo-gln-i, the major polypeptide component of human serum high density lipoprotein, has four noninteracting hydrophobic sites which associate with alkanes, anionic detergents, and cationic detergents. hexane and octane bind to these sites with association constants of 6.8 times 10-2 and 1.8 times 10-4 liters/mol, respectively, and compete with the anionic detergent, sodium dodecyl sulfate (c12oso3-minus), at low detergent ligand binding ratios (i.e. smaller than or equal to 1.0 mol of c12oso3-mi ...1975165177
regulation of adenosine 3' :5'-monophosphate efflux from rat glioma cells in culture*.rat glioma cells grown in culture secrete cyclic adenosine 3':5'-monophosphate (cyclic amp) into the culture medium following stimulation by beta-agonistic catecholamines. agents which reduced cellular atp levels such as valinomycin, oligomycin, and uncouplers of oxidative phosphorylation, inhibited cyclic amp efflux. secretion of cyclic amp was also prevented by prostaglandin a-1 and pharmacological agents including probenecid and papaverine. of the latter agents, only papaverine reduced atp le ...1975165200
thyroid-stimulating hormone and cyclic adenosine 3',5'-monophosphate in the regulation of thyroid gland function.the initial step in tsh action reflects binding of the hormone to specific receptor sites on the plasma membrane. such binding has been studied using plasma membranes, homogenates, isolated thyroid cells grown in culture, and thyroid slices. 3-h- and iodinated tsh preparations have been used; the latter have been prepared using both chloramine-t and lactoperoxidase. some of the discrepancies reported in the literature might reflect the different thyroid and hormone preparations and the variable ...1975165359
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