entry of beta-n-oxalyl-l-alpha,beta-diaminopropionic acid, the lathyrus sativus neurotoxin into the central nervous system of the adult rat, chick and the rhesus monkey. 197897367
studies on the low-molecular weight glycoprotein gp-350: molecular and immunological heterogeneity. 197897368
functional specialisation in the visual cortex of the rhesus monkey.anatomical and functional studies of the visual cortex of the rhesus monkey have shown that it is made up of a multiplicity of distinct areas. these seem to be functionally specialised to analyse different features of the visual environment.197897565
long term effects of myochrysine in articular cartilage.intra-articularly administered sodium aurothiomalate (myochrysine) produced aurosomes containing characteristic electron dense contents (indicating the presence of gold), in the chondrocytes of rabbit articular cartilage. at first the aurosomes were bounded by a membrane but later the electron dense contents were seen lying free in the cytoplasmic matrix. such deposits were detectable up to 14 months after injection of myochrysine but none were found at later time intervals (18 months and 2 year ...197897856
[prospects for the use of blood substitutes made in the ussr with the expired date of validity].as revealed, blood substitutes--aminopeptide, caseine hydrolysate, and hydrolysine with the expired date of validity could be used as the basis of nutrient media for the cultivation of bacteria. bacterial growth proved to be the optimum in addition to the blood substitutes of a 0.25--0.5% of yeast extract.197897885
purification of a specific antigen of trypanosoma cruzi from culture forms.a monospecific rabbit antiserum was prepared against a specific component of tryanosoma cruzi epimastigote culture forms (designated antigen 5). rabbits were immunized intradermally in 30-50 sites with the zone of agarose gel in which the component 5:anti-5 complex was visualized after two-dimensional immunoelectrophoresis. with this appropriate antiserum and the total epimastigote soluble extracts, the specific component of t. cruzi was purified by immunoadsorption. purity and specificity contr ...197898064
cellular uptake, transport, and macromolecular binding of benzo(a)pyrene and 7,12-dimethylbenz(a)anthracene by human cells in vitro. 197898231
progesterone levels in monkeys immunized with pr-beta-hcg-tt after injection of hlh and hcg during luteal phase. 197898288
passive immunization with an antibody to the beta-subunit of ovine luteinizing hormone as a method of early abortion--a feasibility study in monkeys (macaca radiata).antiserum to the beta-subunit of ovine luteinizing hormone (olh-beta) raised in monkeys (macaca radiata) has been tested by a variety of criteria both in vivo and in vitro to establish its ability to neutralize olh, hlh, and human chorionic gonadotropin (hcg). passive administration of this antiserum caused inhibition of ovulation and termination of pregnancy in recipient monkeys as indicated by premature vaginal bleeding and a significant reduction in serum progesterone and estrogen levels. the ...197898358
[action of some bacterial proteases on calf kidney cells cultured in vitro]. 197798380
formylation of initiator trna methionine in procaryotic protein synthesis: in vivo polarity in lactose operon expression.eucaryotic and procaryotic organisms differ in two aspects of their translation machinery: polycistronic messengers are expressed as a sequence of individual proteins only in procaryotes, and the initiation of protein synthesis proceeds with an initiator trna which is found to be modified (formylated) in procaryotes and not in eucaryotes. in the present study, we show that formylation is required in vivo for the coordinate expression of the escherichia coli lactose operon. our experiments are co ...197898518
characterization and genetic control of the immune response to synthetic polypeptide antigens of defined geometry.both humoral and cell-mediated immune responses to the synthetic helical hapten-carrier conjugate poly-glu-tyr-lys(tnp)-(glu-tyr-ala)5 were found to be linked to the major histocompatibility locus in mice and guinea pigs. the responder mouse strains (h-2d haplotype) showed a primary igm response with an igg component appearing after the secondary immunization. the antibody response was accompanied by a positive dth reaction in responder strains. nonresponder mice (h-2b or h-2k haplotypes) showed ...197898587
effect of dopamine on renal blood flow of baboon in endotoxin shock.renal vasodilation observed in canine endotoxemia did not occur during endotoxin shock in the baboon: in fact, renal artery blood flow was markedly reduced. infusion of dopamine in the baboon restored the renal artery blood flow.197898752
[immunological relations between mother and child during pregnancy (author's transl)].the relations between the maternal and foetal organisms during pregnancy are partly very complicated and remain inexplicable. blastocyst, trophoblast, embryo and foetus have membrane antigens at a very early stage, and the immunocompetence of the foetus develops already during the second third of the pregnancy period. many non-specific factors are involved in preventing the castingoff reaction of the foetal organism. the trophoblastic tissue is probably of central importance. the focal point of ...197898927
[some aspects relating to the aflatoxin generation during the self-heating of cereals].in a stored batch of grain which was already affected by mould-formation tests were carried out with the known aflatoxin producer aspergillus flavus. a significantly lower aflatoxin production ensued if the mould growth was not connected with self-heating of the stored product. however, in conformity with increasing mould formation the germinating power was adversely affected and the significant signs (fatty acid number, reductive and none-reductive sugars) were influenced in the grain, irreleve ...197898933
age-associated changes in the blood picture of the goat. 197898936
jaundice and breast-feeding among alaskan eskimo newborns.the course, incidence, and severity of neonatal jaundice was studied in 95 alaskan eskimo infants. breast-fed infants had higher bilirubin concentrations than bottle-fed babies. both groups experienced high bilirubin levels, similar to those previously reported in navajo and oriental infants but greater than those observed in whites and blacks. a marked capacity to inhibit hepatic glucuronyl transferase was observed in breast-milk specimens but only partly accounted for the bilirubin differences ...197899026
platinum nephrotoxicity.platinum coordination complexes have recently been introduced in cancer chemotherapy with considerable success. however, significant nephrotoxicity has emerged as a factor that limits the therapeutic usefulness of these compounds. in this article we review the available knowledge on platinum nephrotoxicity and its prevention that has been derived from both toxicologic studies in animals and clinical trials in human subjects.197899034
fibrinogen turnover in pregnant rabbits during the first and last thirds of gestation.although thrombin-mediated fibrinogen derivatives have been observed in normal pregnancy, an increased turnover of fibrinogen has been suspected but has not yet been demonstrated. fibrinogen turnover was studied in 14 pregnant and 10 nonpregnant female rabbits by use of purified rabbit 125i-labeled fibrinogen. in the last third of gestation the half life of fibrinogen was shortened by 45% and the fractional catabolic rate increased by 44% in comparison to the values for the first third of gestat ...197899036
pars plana vitrectomy as a primary treatment for acute bacterial endophthalmitis.we successfully treated six patients with culture-proven acute bacterial endophthalmitis by a combination of emergency pars plana vitrectomy and the instillation of intravitreal antibiotics. all six patients regained satisfactory vision.197899040
interferon inducing activity of polyinosinic acid.although poly(i) is generally considered to be inactive as an interferon inducer, we have found several authentic poly(i) preparations to be effective inducers. their interferon inducing ability varied considerably from one cell system to another. in human diploid fibroblasts, primed with interferon and superinduced by cycloheximide and actinomycin d, all active poly(i) samples proved nearly as effective in inducing interferon as poly(i).poly(c). in primary rabbit kidney cell cultures, the activ ...197899486
[synthesis and biological activity of 3-quinolineacetic acid derivatives (author's transl)]. 197899509
evidence for a c-terminal tyrosine residue in human and mouse b-lymphocyte membrane mu chains. 197899661
electrophoretic strand separation of long dnas with poly (u,g) in agarose gels.we have found that binding of poly(u,g) to single-stranded dna decreases its mobility in 0.3% agarose gels. differential binding to the complementary strands of denatured duplex dna provides a simple method for strand separation. the method is shown to work with bacteriophage lambda dna, adenovirus dna and mtdna for tetrahymena pyriformis. in all cases the strand that binds more poly(u,g) in cscl gradients also binds more in gels. the separated strands can be directly blotted from the gel onto n ...197899728
behavioral measurement measurements of excitability changes in reward sites in the dog: a frequency dependent effect. 197899757
[in vivo fate of environmental carcinogens (author's transl)]. 197899765
[method of determining the antimicrobial activity of alcohol extracts of propolis].it is proposed to determine the antimicrobial activity of propolys alcohol extracts by the method of subsequent dilutions in solid nutrient media. dilution of the extracts immediately in hot agar eliminated the inhibiting effect of the extragent on the microbial growth. opalesence appearing in the agar did not prevent estimation of the results in contrast to the method of subsequent dilutions in liquid nutrient media.1978100047
preparation and properties of a phospholipid-free form of microsomal udp-glucuronyltransferase. 1978100135
molecular structure of the teichuronic acid of bacillus megaterium. 1978101233
strain-dependent cytotoxic effects of endotoxin for mouse peritoneal macrophages.the cytotoxic effects of bacterial lipopolysaccharides (lps) on mouse leukocytes have been examined in vivo and in vitro. intraperitoneal injection of lps into c57bl/6 mice greatly reduced the recovery of mononuclear cells; lps was cytotoxic for macrophages, but had a mitogenic effect on lymphocytes. similar effects of lps on peritoneal leukocytes were observed in vitro. when monolayers of adherent peritoneal cells were studied in vitro, cytotoxicity was also observed, suggesting that the effect ...1978101460
serologic typing of rickettsiae of the spotted fever group by microimmunofluorescence. 1978101593
[studies of antibody against shigella in bacillary dysentery patients and carriers. report 4. comparison of the results obtained from igg antibody absorption with protein a-sepharose cl-4b and from those with indirect radioimmunoassay (author's transl)]. 1977101599
[studies on moraxella. i. a new selective medium for moraxella sp. (author's transl)]. 1977101603
[epidemiological study on beta hemolytic streptococci among healthy school children in toda city, saitama (author's transl)]. 1978101618
[bacteriocin (marcescin) typing of serratia marcescens. ii. the distribution of serratia marcescens in hospital and its isolated cases by bacteriocin (marcescin) typing (author's transl)]. 1978101627
effect of hypotension induced by sodium nitrocyanoferrate (iii) on the release of arginine-vasopressin in the unanaesthetized monkey. 1978101639
primum non nocere and the sydney funnel-web spider (continued). 1978101753
histologic study of tooth transplantation in the rabbit.tooth transplantation between preimmunized unrelated mismatched animals appears to induce the same immunologic problems that appear in the grafting of other organs. such transplants showed more inflammatory root resorption and ankylosis and less reattachment of periodontal ligaments than did allografts between compatible animals. it appears that transferring the teeth to the similar side, suturing the gingival soft tissue around the teeth, splinting the transplanted teeth, and antibiotic therapy ...1978101931
quantitative assessment of bactericidal activities of beta-lactam antibiotics by agar plate method.quantitative bactericidal activities of beta-lactam antibiotics were determined by the agar plate method. broth cultures, of which the colony-forming units were counted before the study, were inoculated on antibiotic-containing agar plates, utilizing a 10(-3), 10(-2), or 10(-1) dilution or undiluted culture plated with each 0.001-ml calibrated loop. these plates were incubated at 37 degrees c overnight, and the minimal drug concentration at which no bacterial growth was observed on the plates wa ...1978102246
[species specific esterase profiles in the genus serratia].esterases of 62 serratia marcescens, s. liquefaciens, s. plymuthica and s. marinorubra strains were analysed by electrophoresis in polyacrylamide-agarose gel. the comparative distribution of bands showed that the four serratia species were characterized by distinct electrophoretic patterns of their esterases.1978102456
susceptibility of the anaerobic bacteria, group d streptococci, enterobacteriaceae, and pseudomonas to semisynthetic penicillins: carbenicillin, piperacillin, and ticarcillin.sodium piperacillin t-1220, a new semisynthetic penicillin, was tested in vitro against 297 clinical isolates of anaerobic bacteria and 669 aerobic bacteria by the conventional agar dilution method and compared with carbenicillin and ticarcillin. at a 100-mug/ml concentration the three drugs showed comparable effectiveness against the anaerobes tested. however, at 20 mug/ml, piperacillin was the most effective drug against bacteroides fragilis, peptostreptococci, and group d streptococci. at thi ...1978103491
dry-heat destruction of lipopolysaccharide: dry-heat destruction kinetics.dry-heat destruction kinetics of lipopolysaccharides from escherichia coli, serratia marcescens, and salmonella typhosa at 170 to 250 degrees c are described. the destruction rate seems to follow the second order and can be linearized by the equation, log y = a + b . -10cx. because c is the slope, 1/c = d3. both a and b are constant at a given temperature and are linear functions of temperature. the d(3)170, d(3)190, d(3)210, d(3)230, and d(3)250 values for e. coli lipopolysaccharide are 251, 99 ...1978103502
acyldiglucosyldiacylglycerol-containing lipoteichoic acid with a poly(3-o-galabiosyl-2-o-galactosyl-sn-glycero-1-phosphate) chain from streptococcus lactis kiel 42172.the lipoteichoic acid of streptococcus lactis kiel 42172 was isolated. the lipid portions were released by hf and were established to be 3-o-[o-alpha-d-galactopyranosyl-(1 leads to 6)-alpha-d-galactopyranosyl]-2-o-alpha-d-galactopyranosyl-sn-glycero-1-phosphate, they are joined by phosphodiester bonds nosyl)]glycerol. the repeating units of the hydrophilic chain were established to be 3-o-[o-alpha-d-galactopyranosyl-(1 leads to 6)-alpha-d-galactopyranosyl]-2-o-alpha-d-galactopyranosyl-sn-glycero ...1978103572
focal penicillin epilepsy in an isolated cerebral hemisphere. 1978103744
toxoplasma gondii: penetration into differentiating friend erythroleukemia cells. 1978103745
a receptor for polymerized human and chimpanzee albumins on hepatitis b virus particles co-occurring with hbeag.a receptor for polymerized human serum albumin was demonstrated on dane particles as well as on 20-nm hepatitis b surface antigen particles, isolated from asymptomatic carriers of hepatitis b virus who were positive for hbeag. in contrast, such receptor was not born by 20-nm hepatitis b surface antigen particles obtained from carriers positive for antibody to hbeag. hepatitis b surface antigen particles with the receptor were heavier than those without, and when treated with pronase, they became ...1979103774
[serratia in respiratory tract infection (author's transl)]. 1978103986
transcription and translation in a pleiotropic streptomycin-resistant mutant of escherichia coli.the role of the ribosomal protein s12 (streptomycin protein) in ribosome function and in other metabolic processes in the cell has been investigated. a spontaneous streptomycin-resistant strain of escherichia coli (sm3) carrying a mutation in the rpsl gene is deficient in its ability to induce the synthesis of the enzyme bets-galactosidase. it was demonstrated that the reduced rate of enzyme synthesis results from deficiencies in both the transcription of the lactose operon and translation of th ...1979104958
isolation of an iron-binding compound from pseudomonas iron-binding compound was isolated from ethyl acetate extracts of culture supernatant fluids of pseudomonas aeruginosa and was purified by successive paper and thin-layer chromatographic procedures. the purified compound was characterized by uv, visible, infrared, and fluorescence spectroscopy. the compound possesses phenolic characteristics, with little or no similarity to dihydroxybenzoates and no indication of a hydroxamate group. p. aeruginosa synthesized the compound during active growth ...1979104968
homology of the gene coding for outer membrane lipoprotein within various gram-negative bacteria.the mrna for a major outer membrane lipoprotein from escherichia coli was found to hybridize specifically with one of the ecori and one of the hindiii restriction endonuclease-generated fragments of total dna from nine bacteria in the family enterobacteriaceae: e. coli, shigella dysenteriae, salmonella typhimurium, citrobacter freundii, klebsiella aerogenes, enterobacter aerogenes, edwardsiella tarda, serratia marcescens, and erwinia amylovora. however, among the enterobacteriaceae, dna from two ...1979104972
effect of light on the attachment of cyanophage as-1 to anacystis nidulans.the effect of illumination on the extent and kinetics of the adsorption of cyanophage as-1 to the blue-green alga (cyanobacterium) anacystis nidulans was studied by using 32p-labeled phage. the initial rate of adsorption was not significantly affected by light. however, at na+ levels used ordinarily to culture the alga ([na+] = 11.7 mm), the total amount of phage adsorbed was doubled in the illuminated cultures, as compared with the dark-grown ones, over a wide range of multiplicities of infecti ...1979104977
the primary structure of lactobacillus casei thymidylate synthetase. iii. the use of 2-(2-nitrophenylsulfenyl)-3-methyl-3-bromoindolenine and limited tryptic peptides to establish the complete amino acid sequence of the enzyme. 1979105005
effects of the tumor-promoting agent 12-o-tetradecanoylphorbol-13-acetate on normal and "preneoplastic" mouse submandibular gland epithelial cells in vitro.the effect of the promoting agent 12-o-tetradecanoylphorbol-13-acetate (tpa) was studied on mixed primary cultures of c57bl/icrf-at mouse submandibular gland and on slowly proliferating preneoplastic epithelial foci derived from such cultures. no cytologic alterations were noted in the tpa-treated epithelium. the development of three-dimensional epithelial ducts occurring between 30 and 60 days in vitro in untreated cultures was markedly inhibited in tpa-treated cultures. epithelial proliferatio ...1979105202
acute leukemia following prolonged cytotoxic agent therapy.1. nine patients in whom acute non-lymphoblastic leukemia (anll) developed following prolonged alkylating agent therapy are described. five of the patients received no radiotherapy. the conditions treated were: hodgkin's disease (four patients), primary amyloidosis, primary macroglobulinemia, malignant lymphoma, multiple myeloma, and carcinoma of the tonsil. 2. prior to the advent of chemotherapy, this complication was not observed in large series of patients with lymphoproliferative disorders a ...1979105227
the public voice and the nation's health. notes from your faithful but beleaguered participant observer at the battlefront.a professional layman speculates on the role of public voice in medical care--on ways of making organizations responsive to the public's wishes. research conducted as a participant observer in the functioning of human subjects committees, hospital trustees, and a government regulatory body reveals the public interest to be no match for the special interest. unusual proposals are offered to improve the public's control mechanisms; the marketplace and the polling place may yet serve well.1979105313
social and seasonal influences on testosterone secretion in the male rhesus monkey. 1978105367
[evolution and transformation in animal organism of some polychlorobiphenyls (author's transl)].intoxication by pure polychlorobiphenyls and a commercial product is studied, in rats, after intraperitoneal and oral administration. their fixation and excretion of their metabolites is greater by intraperitoneal than by oral administration. the only hydroxy metabolites, identified by means of synthesis, gas chromatography and mass spectrometry are, all, derivatives from trichlorobiphenyl. it appears that administration of commercial product induces a more rapid degradation of these compounds i ...1978105430
[isolation of treponemas from the colon of pigs with clinical dysentery].optimal culture conditions in artificial nutritive media were determined for a defined avirulent strain of treponema hyodysenteriae and for four field strains of treponemas in pigs with clinical dysentery. the treponemas were isolated with the use of milliporous filters with pores of 0.3 micrometer in diameter, which were located on the surface of blood agar. no significant difference in the influence of equine, bovine or sheep blood on the growth of treponemas was determined. the commercial amo ...1979105448
[comparison of the suitability of phase-contrast and immunofluorescence technics in the laboratory diagnosis of porcine dysentery].immunofluorescence technique, compared with the method of phase contrast, does not appear to be better for laboratory diagnostics of swine dysentery because neither of these methods can be used for distinguishing between pathogenic and nonpathogenic strains of treponemas. the number of treponemas contained in faeces should still be considered to be the main criterion in laboratory diagnostics. in clinically healthy pigs from stocks which never suffered from dysentery treponemas were found only i ...1979105449
[b. cereus count in meat and dairy food products].studies were carried out to establish the contamination of some meat and dairy food products with b. cereus. a total of 48 heat-treated sausages (32 perishable and 16 durable) and 64 batches of pasteurized milk were sampled. it was found that 25 per cent of investigated sausage samples contained b. cereus. perishables proved to a considerable extent more frequently contaminated (33.3 per cent). the count of b. cereus in such products ranged from 10(1) to 10(3) per g. however, pasteurized milk wa ...1978105462
[lysozyme concentration in the loose connective tissue of animals with different species sensitivity to brucellosis].lysozyme content was determined in the subcutaneous cellular tissue of guinea pigs and albino rats differing by species resistance to brucella infection. experiments were conducted on intact animals and those inoculated subcutaneously with live br. abortus 19-ba vaccine. connective tissue was taken from the site of the vaccine administration and from the contralateral side (control). observations showed connective tissue of the animals highly sensitive to brucella infection to be exceedingly poo ...1978105522
transport of oligomeric iga of systemic origin into external secretions. 1978105568
the necessity of magnesium cation for acid assistance aglycone departure in catalysis by escherichia coli (lacz) beta-galactosidase.1. removal of mg2+ from escherichia coli (lacz) beta-galactosidase slightly increases the rate of hydrolysis of galactosyl pyridinium salts, but decreases the rate of hydrolysis of arylgalactosides. 2. fair correlation of logkcat. and log (km) with the pka of aglycone is now observed for arglygalactosides, as well as for glycosyl pyridinium salts. 3. degalactosylation of mg2+-free enzyme is the rate-limiting step in the hydrolysis of 2,4-dinitrophenyl galactoside. 4. alpha-deuterium kinetic isot ...1978105722
relationship between biotin-binding proteins from chicken plasma and egg yolk.the plasma of laying hens contains a specific biotin-binding protein that appears to be identical with an egg-yolk biotin-binding protein. both proteins are saturated with biotin and require elevated temperatures to effect the exchange of [14c]biotin for the protein-bound vitamin. the heat-exchange curve in each case is the same and differs sharply from that of avidin, the egg-white biotin-binding protein. on sephadex g-100 gel filtration, plasma and yolk biotin-binding proteins were each eluted ...1978105724
substrate specificity of 5'-methylthioadenosine phosphorylase from human prostate.5'-methylthioadenosine phosphorylase was purified approx. 340-fold from human prostate by using affinity chromatography by hg-coupled sepharose. the enzyme, responsible for the breakdown of 5'-methylthioadenosine into adenine and methylthioribose 1-phosphate, was partially characterized. the apparent km for 5'-methylthioadenosine is 25 microm. it is activated by thiols and shows an absolute requirement for phosphate ions. new analogues of 5'-methylthioadenosine were prepared and their activity a ...1978105725
further observations on the initiation of sperm motility. 1978105770
isolation of meningococci in meningococcal endophthalmitis.we describe a case of bilateral hypopyon in a 7-year-old african male receiving systemic antibiotic therapy for meningococcal meningitis. aqueous from paracentesis of the left eye contained intra- and extra-cellular gram negative diplococci. we believe this is the first report of isolation of the organism since the advent of antibiotic treatment.1979105789
production and characterization of two hemolysins of bacillus cereus.bacillus cereus strain b-48 produced two hemolysins with molecular weights of 52,000 (h-i) and 31,000 (h-ii). a mutant was isolated that produced only h-ii but was identical with the wild type in all other respects. we exploited this mutant to produce h-ii for study that was free of contamination by h-i. by manipulation of media composition, we produced h-i in the absence of h-ii. the hemolysins were precipitated differently by ammonium sulfate, and both exhibited the arrhenius effect when heate ...1978105792
therapeutic experience with netilmicin.netilmicin, a new aminoglycoside antibiotic, was used to treat 19 patients with urinary tract infection and 5 with systemic infection. the causal organisms were escherichia coli (in 2), klebsiella pneumoniae (in 4), serratia marcescens (in 12) and pseudomonas aeruginosa (in 7); 1 patient was infected with two of these organisms. all the isolates of causal organisms except one of serratia were initially sensitive to netilmicin but many were resistant to other aminoglycosides. sixteen of the urina ...1978105797
animal models for the comparative assessment of neurotoxicity following repeated administration of vinca alkaloids.neurotoxicity is the major side effect occurring during the clinical use of vincristine (vcr). animal models predictive of potential neurotoxicity would be very useful in the preclinical development of new vinca compounds. to simulate conditions in which neurotoxicity is produced during the clinical use of vcr, experimental animals (except the guinea pig) were given the test compounds by the iv route over a prolonged time period. doses were selected based on the production of leukopenia. vindesi ...1979105807
cryopreservation of antibody-coated human erythrocytes. 1978105832
studies on autoregulation of prolactin secretion from perifused rat pituitary glands in the basal and thyrotropin-releasing hormone-stimulated states. 1978105892
effect of continuously increasing concentrations of plasma ketone bodies on the uptake and oxidation of glucose by muscle in man.muscle metabolism in man was studied by measuring the arterial and deepvenous concentrations of glucose, lactate, pyruvate, free fatty acids, beta-hydroxybutyrate and aceacetoacetate, and forearm blood flow. after the subjects had fasted overnight, their arterial free fatty acid and ketone levels rose continuously during a period of 90 min, leading to increased ketone body uptake by muscle. hence, for each subject, a relation was obtained between arterial concentrations and arterial-deepvenous d ...1978105915
food toxins and their implication in human health. 1978105997
[false-negative antiglobulin-(coombs-) test caused by anticomplement bovine albumin batches in the transfusion preparation].different brands of bovine albumins were tested as reagent in the second step of the so called 3-stage-screening test for irregular blood group antibodies. in 3 of 9 brands of bovine albumin there was anticomplementary activity which was the cause of diminished or negative reactions in the third stage of the screening test (antiglobulin stage). the disadvantageous brands of bovine albumin contained na2-edta which revealed to be responsible for the anti-complementary activity.1979105998
defective cellular immunity to gram-negative bacteria in cystic fibrosis vitro lymphocyte responses to pseudomonas aeruginosa have been found to be impaired in cystic fibrosis patients with advanced clinical disease. the responses to klebsiella pneumoniae, serratia marcescens, and proteus mirabilis were studied in a similar group of cystic fibrosis patients and normal individuals. cystic fibrosis patients found to be unresponsive to pseudomonas were also unresponsive to klebsiella, serratia, and proteus. responsiveness to staphylococcus aureus was not impaired in ...1979106011
on the contraction of myosin-extracted skinned single fibers with active myosin fragments. 1979106049
rapid micro-carbohydrate test for confirmation of neisseria gonorrhoeae.a rapid carbohydrate utilization procedure for the confirmation of neisseria gonorrhoeae and identification of other neisseria species has been developed. this method utilizes both preformed enzymes, introduced in a heavy inoculum, and enzymes formed by the microorganisms as a result of growth in a small volume of super-enriched medium. expected carbohydrate reactions were produced by 383 clinical isolates of neisseriae and were clearly visible within 4 h of incubation. the combined use of dispo ...1978106068
computed tomography in a primate stroke model using selective balloon catheter arterial occlusion.ten heparinized nonhuman primates (rhesus monkeys and papio maryumaya baboons) were subjected to temporary occlusion of an insular branch of the middle cerebral artery with a balloon catheter. an infarct was created. the lesions were monitored in vivo by computed tomography performed at intervals for 1 year. animals were sacrificed and the lesions examined histologically. the technique obviates the disadvantages of surgical reaction, intravascular thrombosis, and gross cerebral edema observed in ...1979106076
disinfection of nitrous oxide inhalation equipment.cross-infection by contaminated equipment is a potential hazard associated with conscious sedation with nitrous oxide and oxygen . nosocomial infections have occasionally been linked wih the use of unsterile inhalation devices; microbial contamination of sterile nasal hoods routinely occurs during administration of nitrous oxide; and in vitro experiments indicate that subsequent use of contaminated nasal masks may lead to aspiration of microorganisms. although the incidence of respiratory diseas ...1979106079
studies on transduction process by spp1 phage.the conditions for optimal transduction efficiency of the bacillus subtilis phage spp1 have been investigated. by irradiating transducing lysates with u.v. light we have been able to obtain a fivefold increase in the number of transductants and to reduce strongly the interference caused by infective particles. any dependence of spp1 transduction on pbsx induction has been ruled out by the use of xin mutants, which are unable to induce the defective phage. spp1 mediated transduction is susceptibl ...1978106091
immunological comparison of hepatic and extrahepatic cytochromes p-450. 1979106233
cross-reactions between mycobacteria. ii. crossed immunoelectrophoretic analysis of soluble antigens of bcg and comparison with other mycobacteria.cross-reactions between mycobacterium bovis bcg and various other mycobacteria, nocardia asteroides, corynebacterium pyogenes and listeria monocytogenes were studied by incorporating antibodies against these bacteria in the intermediate gel of a crossed immunoelectrophoretic system with bcg antigen and anti-bcg antibodies. in the bcg reference system forty-four distinct antigenic components were recorded, of which thiryt-three cross-reacted with mycobacterium tuberculosis, twenty-five with m. av ...1979106465
tk polyagglutination associated with reduced a and h polyagglutinable erythrocytes are described in which a and h activities were reduced. it is suggested that bacteroides fragilis isolated from cultures of the patient's blood was responsible for each of these membrane modifications.1978106548
the role of catecholamines in clinical medicine.the sympathetic nervous system is of major importance for the regulation of several physiological functions. drugs which inhibit the actions of catecholamines and adrenergic drugs are used in the treatment of many clinical disorders. the potential role of catecholamines in a number of human diseases has, however, until recent years been studied to a limited extent only due to lack of methods for quantitation of sympathetic nervous activity. after the development of enzymatic isotope-derivative a ...1979106629
hospital isolates of serratia marcescens transferring ampicillin, carbenicillin, and gentamicin resistance to other gram-negative bacteria including pseudomonas aeruginosa.thirteen independent isolates of serratia marcescens associated with nosocomial urinary tract infections were obtained from the clinical microbiology laboratory at hines veterans administration hospital. the isolates were resistant to at least ampicillin, carbenicillin, gentamicin, and tobramycin. they could be divided into two groups on the basis of their antibiotypes. group i (9 strains) showed resistance to 13 antibiotics, including 3 beta-lactams, 6 aminoglycosides, tetracycline, sulfonamide ...1979106772
preliminary experimental data on inhibition of beta-lactamase i from b. cereus by cu (++) and zn(++). 1978106864
[intensification of antibacterial and antiviral nonsusceptibility and of the immune response with an officinal rna preparation].sodium nucleinate increased essentially the insusceptibility of mice to pathogenic escherichia, strain o26, pr. vulgaris, ps. aeruginosa, ser. marcescens, and produced a total stimulating effect on the nonspecific bacterial resistance; analogous stimulating activity was found in the homologous low polymeric rna from the liver. sodium nucleinate intensified the insusceptibility of the animals to the tick-born encephalitis and encephalomyelitis viruses, and increased the antibody-forming cells cou ...1979106911
penicillin-resistant gonorrhea. 1979106997
liver transplantation. 1979107000
monooxygenase and glucuronyltransferase activities in short term cultures of isolated rat hepatocytes. 1979107042
relationship of iodide-induced increase in tsh response to trh to changes in serum thyroid hormones.large doses of iodide (500 mg three times a day) administered to normal men for 10--12 days caused a rise in basal serum tsh and a concomitant rise in the peak tsh response to trh. the basal and peak levels of tsh were highly correlated (p less than 0.001). however, the iodide-induced rise in the peak tsh after trh was poorly correlated with concomitant changes in serum thyroid hormones. serum t3 wa not lower after iodide and, while serum t4 was somewhat lower, the fall in serum t4 was unexpecte ...1979107106
carbonic anhydrase of human endometrium: biochemical & clinical aspects. 1978107115
microtubules and the regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase.cultured c-6 glial cells were utilized to evaluate the effect of antimicrotubular drugs on 3-hydroxy-3-methylglutaryl coenzyme a (hmg-coa) reductase and cholesterol synthesis. colchicine, colcemid, and vinblastine (1.0 mum) caused a marked reduction in hmg-coa reductase activity and, as a consequence, the rate of cholesterol synthesis in these cells. no effect was observed with lumicolchicine, a mixture of colchicine isomers with no effect on microtubules. the effect of colchicine was apparent w ...1979107160
antigenic analysis of sequential erythrocytic stages of plasmodium knowlesi.the antigenic composition of sequential erythrocytic stages of plasmodium knowlesi has been compared by crossed immuno-electrophoresis using a pool of immune rhesus monkey antiserum. eleven major parasite antigens have been identified; 9 are stage-independent, and 2 stage-dependent. differences in the relative amount of the stage-independent antigens have been demonstrated and quantified. the distribution of antigens between parasites and schizont and infected red cell membranes has been examine ...1978107503
interpretation of serum and red cell folate results. a comparison of microbiological and radioisotopic methods.serum folate and red blood cell folate levels were measured in 167 patients using a microbiological method (lactobacillus casei) and a commercial 125i radioassay kit. the results of the two methods were compared and related to the clinical findings to see which method more truly reflected the physiological folate status of the patient. there was a good linear correlation between the methods for both serum folate and red cell folate over the whole range encountered and the mean results obtained w ...1979107505
a three month inhalation toxicity study in the squirrel monkey (saimiri sciureus) with terbutaline sulfate (bricanyl).a study of the subacute toxicity of inhaled terbutaline sulfate was performed in the squirrel monkey (saimiri sciureus). 3 groups of monkeys were exposed 1 h daily 7 days/week for 3 months to terbutaline sulfate aerosols at concentrations of 0.039, 0.185 and 0.799 mg terbutaline/litre of air respectively. a fourth group was a chamber control receiving air only. the following clinical parameters were evaluated: physical appearance and behavior, weight gain, ophthalmoscopic appearance, electrocard ...1978107616
the viability of cryopreserved aegyptianella pullorum carpano, 1928 in the vector argas (persicargas) walkerae kaiser and hoogstraal, 1969. 1979107668
macaca assamensis as a new host for experimental plasmodium knowlesi infection. 1978108217
[investigations on the aminoglycoside inactivating enzyme aac-(6') iv (author's transl)].in serratia marcescens and pseudomonas aeruginosa from clinical specimen acetyltransferase aac-(6') iv leads to varying phaenotypically expressed resistance to aminoglycoside antibiotics. the substrate profile and the rate of inactivation of the enzymes investigated are almost identical with each other and with the enzyme of p. aeruginosa gn 315. the enzymes cannot be associated with r factors by the standard methods for conjugation, transformation, density gradient centrifugation and agarose g ...1979108221
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