skin changes in short-bowel syndrome. kwashiorkor-like infant with short-bowel syndrome developed flexural desquamation and "enamel paint" skin in pressure-bearing areas. hyperalimentation with amino acid and lipid solution was unsuccessful in correcting the malnutrition and skin changes.1977404970
mode of action of the protein, sp127, which enhances the activity of macrolide antibiotics against pseudomonas aeruginosa.antibiotics, the activity of which enhanced against pseudomonas aeruginosa by sp127, were restricted to the basic macrolide antibiotics such as erythromycin, maridomycin and oleandomycin, the neutral macrolide antibiotics such as lankamycin and lankacidin c, vancomycin and enramycin. synergistic activity of sp127 with the above antibiotics was found against pseudomonas aeruginosa and several strains of escherichia coli, but not against proteus vulgaris and macrolide-resistant staphylococcus aure ...1977405356
synergy and rifampicin. 1977405361
laboratory evaluation of pirbenicillin, a new penicillin with antipseudomonal activity. 1977405364
clinical and laboratory study of tobramycin in the treatment of infections due to gram-negative organisms.tobramycin, an aminoglycoside antibiotic, was used to treat 52 infections due to gram-negative organisms in 51 patients. complicated urinary tract infections, bacteremia and pyelonephritis accounted for 80% of the infections. the rate of immediate satisfactory response was 79%. during therapy with tobramycin, resistant organisms emerged in four patients--two pseudomonas aeruginosa and two escherichia coli strains. there were four superinfections with tobramycin-resistant providencia sp. in four ...1977406032
studies on quinoline derivatives and related compounds. 5. synthesis and antimicrobial activity of novel 1-alkoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids.a series of novel 1-alkoxy-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids was synthesized and screened as antimicrobial agents. the most active compounds in vitro against gram-negative microorganisms and staphylococcus aureus were 1,4-dihydro-1-methoxy-6,7-methylenedioxy-4-oxo-3-quinolinecarboxylic acid (22), 1,2,6,9-tetrahydro-6-methoxy-9-oxofuro[3,2-f]quinoline-8-carboxylic acid (30, and 2,3,6,9-tetrahydro-6-methoxy-3-methyl -2,9-dioxothiazolo [5,4-f]quinoline-8-carboxylic acid (34). these comp ...1977406396
[fulminat courses of sepsis in newborn infants and infants]. 1977406522
[subinhibitory concentrations of antibiotics. effects on morphology and growth (author's transl)].experiments with subinhibitory concentrations of antibiotics revealed certain effects that had not been observed at higher concentrations. two different effects are described: morphological changer and inhibition of growth. the expression minimum antibiotic concentration (mac) has been shown to be of both theoretical and practical value. it has served to make plain the differences between the effects of various antibodies that were not observed at the mic. the ratio mac/mic could be be of import ...1977406590
activation of complement by opportunist pathogens and chemotypes of salmonella minnesota.washed cells of staphylococcus aureus, escherichia coli, proteus mirabilis, pseudomonas aeruginosa, and salmonella minnesota chemotypes (s, rb, and re) were tested for their ability to activate the alternative complement pathway (acp). parameters of acp activation were (i) conversion of c3 in 10 mm ethyleneglycol-bis-(beta-aminoethyl ether)-n,n1-tetraacetic acid-treated human serum supplemented with 2.5 mm mgcl2, (ii) lysis of glutathione-treated human erythrocytes in the presence of human serum ...1977408268
comparative studies of rna polymerase subunits from various bacteria.the molecular structure of rna polymerases from escherichia coli, salmonella typhimurium, salmonella anatum,serratia marcescens, aerobacter aerogens, proteus mirabilis and bacillus subtilis were compared based on:i) inhibition of the enzyme activity by treatment with antibodies against e. coli rna polymerase subunits;ii) analysis of antibody precipitates by sodium ododecyl sulfatepolyacrylamide gel electrophoresis; and iii) analysis of antibody precipitates by urea-isoelectrofocusing followed by ...1977408600
effect of systemic antibiotics on the microbial flora of the external ear canal in hospitalized children.the effect of antibiotic therapy and hospitalization on the external ear canal flora was investigated in 131 children. fifty-eight percent of the patients receiving antibiotic therapy had gram-negative bacilli or yeasts in their external ear canal, compared with 17% of the patients who were hospitalized for ten days or longer and only 3% of the patients who were hospitalized for short periods. antibiotic therapy is the major factor in determining the colonization rate of the external ear canal w ...1977408786
[suprapubic puncture of the bladder within the scope of bacteriological urine diagnosis in gynecological-obstetrical patients].technology, evidence as well as indications and contraindications of the suprapubic bladder puncture are shown from a gynecological and obstetrical point of view. the bacteriological result of urine obtained by puncture from 476 women has been compared with that obtained subsequently by midstream voiding. it was proved statistically that bladder puncture yielded less positive results than midstream voiding. in 8.4 per cent of the cases there was a positive voided midstream urine culture with pat ...1977409001
[morphologic characteristics of spheroid elements in a culture of bacterial l-forms according to scanning electron microscopy findings].the authors studied stable l-cultures of proteus valgaris, bac. subtillis, staphylococcus aureus, streptococcus pyogenes of group a, and also unstable cultures of the l-forms of proteus vulgaris and proteus vulgaris culture at the stage of spheroplasts. spheroid cells proved to appear at the stage of spheroplasts, prevailed at the log phase in stable and unstable l-cultures, but were less frequent at the stationary phase. cross section of l-colonies showed that they were located at the surface. ...1977409012
patterns and mechanisms of emergence of resistance to amikacin.emergence of gram-negative bacilli resistant to amikacin occurred in five of 96 patients treated. three of the five instances were associated with clinical failure and arose during therapy for an infection caused by a pathogen also susceptible to gentamicin. the other two episodes were associated with colonization. the enzyme aminoglycoside-6'-acetyltransferase, which inactivates amikacin, was found in serratia marcescens. decreased permeability to amikacin was shown in four isolates of pseudomo ...1977409785
[the basic studies on chemotherapy in urinary tract infection due to organisms with resistance to antibiotics (author's transl)]. 1977409865
[a new type of ointment base: investigations on its antimicrobial properties (author's transl)].a new ointment base (pen 32) consisting of polyalcohols prevents the growth of bacteria and fungi in concentrations above 25% (mg/mg). in a concentrated form the ointment base exhibited excellent bactericidal and fungicidal effects in vitro. this property enables the ointment base to be employed without preservatives.1977410167
a collaborative study on the repeatability and the reproducibility of the dutch standard-suspension-test for the evaluation of disinfectants. 1977410202
[studies on the activation of humoral defense factors against bacteria in larvae of the wax moth galleria mellonella l].the change of lysozyme activity in the hemolymph of the wax moth larvae caused by vaccination is influenced by the size and the dose of the injected particles. the rate of incorporation of those particles into phagocytes has no effect on this process. the change of lysozyme activity correlats negatively with the amount of granulocytes after vaccination. there were no correlations with the amount of other types of the hemocytes, neither with the resistance of the larvae against pseudomonas aerugi ...1977410207
[antibiotic sensitivity of the causative agents of suppurative surgical infection].sensitivity of 1492 strains of the causative agents of the surgical purulent infections, i. e. pathogenic staphylococcus, proteus, ps. aeruginosa and e. coli to benzylpenicillin, streptomycin, levomycetin, tetracycline, erythromycin, oleandomycin, monomycin, kanamycin, novobiocin, ampicillin, oxacillin, ceporin, gentamicin and rifampicin was studied. gentamicin was most active against all the bacterial species tested. the staphylococci were in addition sensitive in a high percentage of the cases ...1977410359
[seroepidemiological investigations on the prevalence of rickettsial antibodies in man in the federal republic of germany (author's transl)].1,600 random serum samples from inhabitants of hesse were investigated for rickettsial antibodies by complement fixation test. antibodies were found in 19 samples (1,2%) against rmsf-group antigen with titers between 1:10 and 1:640. these results confirm recent reports on natural foci of such rickettsial infections in the federal republic of germany. antibodies against rickettsia of the typhus-group or coxiella burnetii could not be detected by the complement fixation reaction. none of the sera ...1977410727
[azlocillin--a new penicillin against pseudomonas aeruginosa and other gram-negative bacteria]. 1977410735
[selective effect of propolis in the isolation of listeria monocytogenes (author's transl)].propolis is a substance produced by honeybees. it is inhibitory to some bacteria species, mainly gram-positive bacteria, but less inhibitory to listeria monocytogenes (l.m) than to the other gram-positive bacteria tested. in order to obtain selective growth of l.m. from contaminated samples, the effect of propolis in plating media and broths on various strains of bacteria was examined. table i shows the effect of increasing concentrations of propolis in tryptose-agar (ta). l.m. tolerated higher ...1977411111
[clinical and pharmacological evaluation of s-6436 (long acting preparation of cephalexin) in urinary tract infections (author's transl)]. 1977411848
[in-vitro effect of tobramycin]. 1977412333
antimicrobial synergism in the therapy of gram-negative rod determine if antimicrobial synergism might affect the results of treatment of gram-negative rod infections, 444 bacteremias from 1972 through 1974 were studied. on these, 173 were treated with two antibiotics to which the infecting organisms were sensitive. clinical responses were observed in 80% of 83 cases where antibiotic activity was synergistic, as defined by a minimum inhibitory concentration (mic) of each antibiotic in combination being one-fourth or less than the mics of individual dr ...1978412648
nocardicin a, a new monocyclic beta-lactam antibiotic iii. in vitro evaluation.nocardicin a, a new monocyclic beta-lactam antibiotic, exerts a comparatively potent antimicrobial activity against gram-negative organisms, especially pseudomonas aeruginosa, the indole-positive and indole-negative proteus groups (except pr. morganii), serratia marcescens and the neisseria groups. the in vitro antimicrobial activity of nocardicin a against clinical isolates of ps. aeruginosa was about twice that of carbenicillin. the mean mics of nocardicin a for pr. mirabilis, pr. rettgeri and ...1977412823
nocardicin a, a new monocyclic beta-lactam antibiotic iv. factors influencing the in vitro activity of nocardicin a.factors influencing the in vitro antimicrobial activity of nocardicin a against pseudomonas aeruginosa and proteus mirabilis were investigated. sodium chloride was identified as a major inhibitor. some of the amino acids, sugars and divalent cations were found to be minor inhibitors. the presence of potassium phosphates enhanced nocardicin a activity against p. aeruginosa, but antagonized the activity against p. mirabilis.1977412824
a comparative investigation of the bactericidal and fungicidal effects of three phenolic disinfectants. 1977412825
plantar ulcers with osteomyelitis underneath. a bacteriological study.39 consecutive cases of plantar ulcers with underlying chronic osteomyelitis admitted in the sacred heart hospital during 1975/1976 were studied for the infecting organisms and their sensitivity to easily available antibiotics. single organism was iasolated in only 10 cases, the infection in the rest being a mixed one. the commonest organisms were staphylococcus, streptococcus and proteus mirabilis. in a few cases pseudomonas and e-coli were also isolated. chloramphenicol was the most effective ...1977413005
[development of resistance. problems of chemotherapy in urology]. 1977413268
lipoquinones of some bacteria and mycoplasmas, with considerations on their functional a comparative study the lipoquinones of some chemoorganotrophic, facultatively aerobic bacteria, and representative acholeplasma, mycoplasma, spiroplasma, and thermoplasma strains were investigated. the quinones were partly purified by preparative thin layer chromatography of lipid extracts, and characterized by their difference spectra (reduced minus oxidized) and rf values. respiring bacteria expectedly contained benzoquinones and/or naphthoquinones in micromolar concentrations whereas some ...1977413478
p-nitrophenylglycerol--a superior antiswarming agent for isolating and identifying pathogens from clinical material.the antiswarming agent p-nitrophenylglycerol (pnpg) has been found invaluable for the recognition and isolation of pathogenic bacteria from specimens contaminated with swarming strains of proteus spp. pnpg is cheap, stable and non-toxic. all strains tested grew well in its presence and produced characteristic morphology. pnpg was without effect on the results of a variety of identification tests performed directly on colonies from media containing pnpg. this permitted identification without the ...1978413924
the formation of germtubes by candida albicans, when grown with staphylococcus pyogene, escherichia coli, klebsiella pneumoniae, lactobacilius acidophilus and proteus vulgaris.the formation of germtubes by twelve clinical isolates of c. albicans was studied in human serum containing per millilitre 10(3) to 10(9) organisms as: staphylococcus pyegene, escherichia coli, klebsiella pneumoniae, lactobacillus acidophilus and proteus vulgaris. all the five bacteria inhibited formation of germtubes by c. albicans at all concentrations and the percent germtube formed diminished with increasing concentration of the bacteria. lactobacillus acidophilus inhibited the formation of ...1977414139
studies of vesicoureteral reflux: a review of work in a primate model.studies of vesicoureteral reflux in a primate model were reviewed. reflux was found to be uncommon in adults but frequent in infants, suggesting that maturation of the ureterovesical junction occurs. repeated bladder infections did not prevent this maturation. infection did not cause reflux unless the junction was only marginally competent. reflux prolonged urinary tract infection in the infant, but in the adult monkey it did not.1978414361
[spinal cord influences on immune responses demonstrated following interruption of the spinal cord as a result of injury].specific and nonspecific immunity reactions were studied in dynamics in 126 patients with injury to the spinal cord, in 162 healthy persons (controls), and in 30 persons who had suffered injury to other organs. the serum agglutinins against the causative agents of infection of the urinary system (colibacillus, proteus, enterococcus) and c-reactive protein were studied. phases were revealed in the course of the immunologic reactions depending on the neurodynamics of the damaged spinal cord. the c ...1977414445
[recommendations for the testing and the evaluation of the efficacy of chemical disinfectant procedures (author's transl)]. 1977414483
dimethyl sulfoxide as an electron acceptor for anaerobic growth.the isolation from lake mud of a bacterium which can use dimethyl sulfoxide (dmso) as an electron acceptor for growth is described. the isolate, called strain dl-1, was a small, gram negative, non-motile spiral. the sole product of dmso reduction was dimethyl sulfide (dms). other electron acceptors used by the isolate included sulfite, thiosulfate, elemental sulfur, methionine sulfoxide, tetramethylene sulfoxide, nitrate, and oxygen (microaerophilically). sulfate was not reduced and could not ev ...1978414686
chemotactic activity of l-forms and mycoplasma.l-forms of streptococcus faecalis, escherichia coli and proteus mirabilis showed significantly less chemotactic activity for normal human leucocytes than did parent bacterial forms which were strongly chemotactic. mycoplasma pneumoniae and mycoplasma hominis did not demonstrate chemotactic activity.1977414709
comparative immunological studies on arylsulfatase in bacteria of the family enterobacteriaceae: occurrence of latent arylsulfatase protein regulated by sulfur compounds and tyramine.the arylsulfatases of 21 strains of the family enterobacteriaceae were compared by measuring their enzymatic activities and immunological reactivities. enzyme formation under repressing, nonrepressing, and derepressing conditions was tested. antiserum prepared against pure arylsulfatase from klebsiella aerobgenes w70 was tested against the enzyme extracts from the strains using double diffusion, quantitative precipitation, and immunoelectrophoresis. no close relationship was found between arylsu ...1978415041
[recognition of bacterial infections in newborns by measuring specific antibody-titres (author's transl)].antibodies were measured in 172 unselected neonates against mixed polyvalent antigens derived from e. coli, klebsiella, ps. aeruginosa and proteus spp. respectively, using a modification of the indirect haemagglutination technique according to neter. 120 of these neonates with no evidence of infection served as controls. 6 out of 8 children with proven e. coli septicaemia had either raised titres or significant rises in titre. five further neonates with septicaemia, four due to klebsiella and on ...1978415229
[aggravation of experimental dysentery in mice and acceleration of the process of multiplication of pathogenic and conditionally pathogenic bacteria under the effect of yeast rna].simultaneous infection of mice with sh. flexneri subtype 2a, culture, with various doses of rna sodium salt (narna) or administration of the preparation 3 hours prior to or 6, 12, and 18 hours after the infection was accompanied by aggravation of the experimental infection in mice. this was expressed in a greater number of animals which contracted the disease and died, and in increased blood and peritoneal exudate microbiol density. the same processes were noted in mice infected with equal doses ...1978415460
antibacterial activity of sisomicin.a study of the in vitro antibacterial activity of a new aminoglycoside, sisomicin, is reported. the results show no significant differences between the activity of sisomicin and gentamicin.1978415913
[investigations on the antimicrobial activity of amin-aldehyde-condensates. 2. communication: unsymmetrically substituted animals of formaldehyde (author's transl)].in the scope of our research about the antimicrobial activity of aldehyde-amin-condensates a number of partly new unsymmetrically substituted animals was synthesized by reaction of formaldehyde with different secondary amines. structures and physically constants are shown in the tables 1 and 2. the antimicrobial activity is demonstrated by the results of the disktest (table 3), of the minimal inhibition concentration (mic, table 4) and the suspension and area disinfecting tests following the met ...1977416627
heterologous transfection with bacteriophage phix174 dna: and improved system.a highly efficient and much more reproducible system for the heterologous transfection of several kinds of gram-negative bacterial spheroplasts with bacteriophage phix174 dna was established. by mild washing of the speroplasts, the efficiency of transfection of all non-host heterologous bacterial species tested increased one or more orders of magnitude in producing the progeny phages and/or the infectious intermediates. using the improved heterologous transfection systems, it has become clearer ...1978418813
prostatitis in the rat.a high incidence of spontaneous, non-acute, age-dependent prostatitis was observed in the lateral prostate of copenhagen rats and wistar rats. the lumen of infected acini was filled with polymorphonuclear leucocytes, shed epithelial cells and cell residues. epithelial cells lining such acini showed degenerative changes. lymphocytes and macrophages were seen in the stroma. a histochemically observed increase in acid phosphatase and beta-glucuronidase activity in affected epithelial cells may indi ...1979419384
[effect of neuraminidase on phagocytosis activity in amoeba proteus (author's transl)]. 1979421771
tetracycline-induced aplastic anemia.a 54-year-old man developed mild renal insufficiency after treatment with gentamicin and cephalothin. he then received tetracycline for eight days, 500 mg orally four times daily, for a total dose of 15 gm. twelve days after discontinuation of the drug, a severe but reversible aplastic anemia developed. we propose that bone-marrow-toxic concentrations of tetracycline resulted from the preexisting renal insufficiency. because of the temporal relationship between tetracycline administration and ap ...1979424834
[the biliary excretion of azlocillin].the excretion of azlocillin into the human biliary tract was investigated in 8 patients with a t-tube in the common bile duct after intravenous injection of 2 g. samples of serum and common duct bile were assayed from 15 min to 12 hours after injection. biliary tract levels generally run parallel to serum levels but were about 15 times higher than those. peak levels in t-tube bile averaged 1137 mg/l 60 to 90 min after administration. 12 hours after administration there were still mean concentrat ...1979428879
urinary tract infection induced by intermittent urethral catheterization in dogs.sterilized and unsterilized catheters were passed into the urinary bladders of 9 clinically normal adult male dogs once daily for 5 consecutive days, and the dogs were examined for up to 30 days to determine whether urinary tract infections developed. two dogs that were catheterized with clean unsterilized catheters (1 clinically normal dog and 1 dog given immunosuppressant drugs) developed persistent cystitis and pyelonephritis due to infection with proteus sp. one dog given immunosuppressant d ...1979429232
o serotyping of providencia stuartii isolates collected from twelve hospitals.a collection of 829 isolates of providencia stuartii, mostly from urological specimens of patients in 12 hospitals, were o serotyped. hospitals varied in serotype distribution, but most isolates (97%) fell into one or another of 14 o types of p. stuartii. one type (o63) was found in 10 hospitals, and six types (o4, o17, o25, o52, o55, o56) were found in 5 or more hospitals. these seven types were more common than others and included 753 (91%) of the isolates. only four isolates agglutinated in p ...1979429535
xanthogranulomatous pyelonephritis (xgp): a local disease with systemic manifestations. report of 23 patients and review of the literature.the clinical, pathological and radiographic findings of 135 cases of xanthogranulomatous pyelonephritis have been reviewed. it is a form of renal suppuration and obstruction most commonly seen in middle aged women although all ages and both sexes may be affected. there is no race predilection. gram-negative organisms are usually present and bilateral involvement has not been reported. the most common offending organism is proteus mirabilis. hepatic dysfunction is seen and appears to normalize wi ...1979431402
urolithiasis in children with spinal cord the literature there is a paucity of references on urolithiasis in children with spinal cord injury. in this paper 28 cases of urolithiasis in 97 children with spinal cord injury are analysed. an attempt is made to evaluate the role of hypercalcemia, hypercalciuria and urinary tract infection in the genesis of these calculi.1979431966
bl-s786 (ceforanide), a new parenteral cephalosporin: in vitro (ceforanide) is a new cephalosporin which showed broad-spectrum activity in vitro against 453 clinical isolates. at a concentration of 3.12 mug/ml, it inhibited greater than 75% of isolates of escherichia coli, klebsiella spp., proteus mirabilis, staphylococcus aureus, streptococcus pyogenes, and streptococcus pneumoniae. essentially no activity was observed against isolates of serratia marcescens, and only minimal activity was observed against enterobacter spp. its activity was directly ...1979426520
hr 756, a new cephalosporin active against gram-positive and gram-negative aerobic and anaerobic bacteria.the in vitro activity of hr 756, 7-[2-(2-amino-4-thiazolyl)-2-(z)-(methoximino)acetamido] cephalosporanic acid, was investigated against 659 isolates. hr 756 inhibited neisseria and haemophilus species at concentrations similar to those needed with ampicillin. it inhibited beta-lactamase-producing n. gonorrhoeae and h. influenzae. hr 756 was the most active compound tested against members of the enterobacteriaceae, inhibiting most isolates of escherichia coli, klebsiella pneumoniae, proteus mira ...1979426518
cefatrizine activity compared with that of other cephalosporins.cefatrizine, a new orally administered cephalosporin, was tested against 400 clinical isolates. cefatrizine had excellent activity against gram-positive cocci, inhibiting all except enterococci at minimal inhibitory concentrations below 1 mug/ml. cefatrizine inhibited the majority of escherichia coli, klebsiella pneumoniae, proteus mirabilis, and salmonella at concentrations below 12.5 mug/ml. although cefatrizine was not hydrolyzed by many beta-lactamases, it did not inhibit a number of strains ...1979426514
dissolution of a struvite nephrolith in a dog.a large radiodense calculus in the left renal pelvis of a 22-month-old, male great dane disappeared one month following surgical removal of two struvite (magnesium ammonium phosphate) calculi from the right renal pelvis. the dog's urine likely became undersaturated with struvite for a sufficient period to permit dissolution of the renal calculus. several factors may have contributed to the decrease in urine struvite concentration, including eradication of a urease-producing proteus sp from the u ...1979438042
[antibiotic sensitivity of the microflora isolated in ent diseases].sensitivity of beta-hemolytic streptococci of group a, streptococcus viridans, staphylococcus aureus, epidermal staphylococci, pneumococci, proteus and ps. aeruginosa isolated in 1975-1978 from patients with tonsillitis, otitis, sinusitis and other otorhinolaryngological diseases was studied with respect to 19 antibiotics. data on comparison of the antibiotic sensitivity of the microflora isolated from the patients with otorhinolaryngological diseases in 1964-1974 and 1975-1978 are presented. it ...1979443782
bacteriology and treatment of chronic otitis media.tympanocentesis was performed in 50 patients with chronic otitis media. pus was cultured aerobically and anaerobically. aerobes only were isolated from 21 patients, 3 had only anaerobes (peptococcus sp.) and 26 had both aerobes and anaerobes. there were 68 aerobic isolates. pseudomonas aeruginosa was recovered in 36 (72%). other aerobes commonly recovered included proteus sp. and staphylococcus aureus. there were 48 anaerobes isolated. anaerobic gram positive cocci were isolated in 24 instances. ...1979449555
[characteristics of the antibiotic sensitivity of nitrofuran--resistant gram-negative bacteria of clinical origin].494 persons with various purulent inflammatory diseases were examined. gram-negative nitrofuran resistant organisms isolated from the clinical material were found in 22.9 per cent of the cases. representatives of enterobacteriaceae, klebsiella-enterobacter-serratia (26.8 per cent), proteus-providencia (16.8 per cent) and e. coli-arizona-citrobacter (16.1 per cent) predominated. pseudomonas (32.1 per cent) and acinetobacter (5.3 per cent) predominated among the aerobic gram-negative bacteria. sen ...1979434799
spermatozoa repellent as a contraceptive.early report by kopp et al. have demonstrated that p-nitrophenyl-glycerol (pnpg) is an effective antiswarming agent in proteus and that this inhibition may have been caused by pnpg interfering with the negative chemotaxis mechanism in the organism. with an inverted capillary assay, designed to test the motility response of rat epididymal spermatozoa to various suspending conditions including those exposed to chemical gradient, pnpg was shown in this study to exhibit an inhibitory effect at sligh ...1979455977
synthesis and antibacterial activity of 2-oxocephalosporins.the first reported synthesis of 2-oxocephalosporin derivatives has been achieved via ozonolysis of the corresponding 2-methylenecephalosporins. the new cephalosporin derivatives showed some antibacterial activity against gram-positive bacteria, but the 2-oxo analogue of cephalothin was much less active than cephalothin itself.1979458825
[clinical studies on pc-904 in biliary tract diseases (author's transl)].the clinical effects of pc-904, a new semisynthetic penicillin, were studied in patients with biliary tract diseases, and the results were as follows: 1) pc-904 showed an average peak serum level of 40.7 +/- 11.6 microgram/ml 2 hours after an intravenous drip infusion of 1 g of the agent. the biliary level showed a peak value of 126.5 +/- 85.4 microgram/ml 2 hours to 3 hours after the infusion. 2) isolated organisms from bile before the treatment were e. coli, klebsiella, proteus, pseudomonas, e ...1979459091
microbiology of superficial and deep tissues in infected diabetic the current study, it is shown that, in the lesions of diabetic gangrene, there are usually mixed flora of two or more organisms. the organisms isolated from the presenting lesion may only partially reflect the organisms found in the deep tissues. of the 58 cultures from the deep tissues, 11 of the isolates were anaerobes, but those anaerobes were never isolated as a pure culture. bacterial synergism probably plays a role in infected diabetic gangrene. maximizing the reduction of systemic inf ...1979462355
[gastrointestinal tract microflora in nonspecific ulcerative colitis].the species and quantitative composition of the normal and conditionally pathogenic microflora of the stomach, the proximal portion of the small intestine, in material obtained by biopsy from the mucosa of this portion, and in feces was studied in 10 patients with non-specific ulcerative colitis. the study was made before and after treatment. before treatment in most of the patients gastric juice and the proximal portion of the small intestine were found to be greatly contaminated with microflor ...1979463429
comparison between agar and broth minimum inhibitory concentrations of cefamandole, cefoxitin, and cefuroxime.the in vitro susceptibility to cefamandole, cefoxitin, and cefuroxime of clinical isolates of streptococcus faecalis, klebsiella, and indole-positive proteus was assayed using minimum inhibitory concentration (mic) determinations in broth and on solid media. it could be demonstrated that the agar dilution mics obtained when s. faecalis was tested against cefuroxime and when indole-positive proteus strains were tested against cefamandole tended to be considerably lower than those obtained with th ...1979464588
[maternal lactation. ii. intestinal colonization in breast fed newborn infants].twenty-three low birth weight infants were studied to establish the role that breast milk plays in the intestinal colonization of the preterm infant, and in the control of epidemic diarrhea due to enteropathogenic e. coli, in nurseries. twelve of these case were fed breast milk in bottles, and eleven with "humanized" powder cow's milk (nan m.r.). bacteriologic studies of feces were performed daily during the first 18 days of life. in 5 cases given breast milk, and in 8 receiving cow's milk, stap ...1979465174
pinocytosis and locomotion of amoebae: xii. dynamics and motive force generation during induced pinocytosis in a. proteus.the mechanism of induced pinocytosis was investigated in amoeba proteus by light and electron microscopy. the application of nine different inducing substances revealed that pinocytotic channel formation, elongation, vesiculation, shortening and disappearance are the result of the successive or simultaneous action of both traction and pressure forces, which are produced by the contractile activity of a plasma membrane-associated layer of filaments ranging from a few hundred nm to several microme ...1979436147
[in vitro testing of newer cephalosporins (author's transl)].the spectrum of activity of the newer cephalosporins is considerably wider and includes a number of gram-negative bacteria. test results using cephalothin as 'class disc' of a class of antibiotics is therefore no longer valid for the newer members. like cefazoline, all of the above-mentioned antibiotics are more effective against escherichia coli. cefuroxin and cefoxitin also display increased effectiveness against klebsiella, as do cefoxitin against serratia and indolpositive proteus species, a ...1979437897
[nosocomial infections with providencia stuartii (proteus inconstans) (author's transl)].48% of all isolates of providencia stuartii obtained within a period of one year, originated from the urine of catheterised patients, whereas another 37% were found in the respiratory tract of patients with intubation. the incidence of providenica stuartii correlated with the period during which iatrogenic measures had been applied, as well as with a preceding course with antibiotics.1979467264
[effect of immunization on the radioresistance of mice administered 137cs]. 1979472157
storage of microtiter plates for antimicrobial susceptibility tests.microdilution susceptibility tests are being performed routinely and in increasing numbers in many clinical laboratories. microtiter plates for these assays are usually prepared in large batches and stored frozen until needed. studies were performed to investigate the stability at -20c and at -70c of ampicillin, carbenicillin, ticarcillin, gentamicin, tobramycin, amikacin, chloramphenicol, and cephalothin, using enterobacter aerogenes, proteus mirabilis, proteus vulgaris, escherichia coli, pseud ...1979474606
[first steps in the bacterial colonization of the digestive tract of neonates (author's transl)].meconium samples obtained from 14 children aged 18 to 51 h were subjected to a quantitative differential analysis. the meconium of one of the children (47 h old) was sterile; in those of the 11 infants aged less than 47 h the dominant flora was composed of either enterobacteria, mainly escherichia coli sensitive to usual antibiotics, or of streptococci. the genus acinetobacter constituted the dominant flora in one case only. staphylococcus, corynebacterium, clostridium (c. perfringens), bacteroi ...1979475219
morphological alterations in the mitochondria of amoeba proteus induced by uncoupling agents.ultrastructural changes in mitochondrial morphology were observed in amoebae exposed to the uncoupling agents dinitrophernol (dnp), pentachlorophenol (pcp), and m-chlorocarbonyl cyanide phenylhydrazone (cccp). these alterations occurred with rapidity and were present before whole-cell activity changes could be detected. they included changes in profile shape and overall dimensions, matrix density changes, and alterations to the cristal membranes, so that distinction between control type i and ty ...1979479326
selection of small-colony variants of enterobacteriaceae by in vitro exposure to aminoglycosides: pathogenicity for experimental animals.small-colony variants of gram-negative genera of enterobacteriaceae were selected by in vitro exposure to gentamicin. these variants were shown to have decreased susceptibility in vitro to aminoglycosides. they were lethal for mice following intraperitoneal injection, with the ld50 (50% lethal dose) being the same as, or slightly less than, that for the parent organism. variants of strain no. 2401 of proteus mirabilis caused urinary tract infection in mice after implantation into their bladders. ...1979479639
trimethylamine oxide: a terminal electron acceptor in anaerobic respiration of bacteria.trimethylamine oxide (tmao) stimulated both the anaerobic growth rate and the growth yield of proteus nthc 153. the molar growth yield from glucose and pyruvate in tryptone/yeast extract medium doubled in the presence of tmao, and the organism grew anaerobically on the non-fermentable substrates l-lactate and formate when tmao was added to the medium. we conclude that tmao stimulated growth by serving as a terminal electron acceptor in an oxidative phosphorylation process.1979479836
prophylaxis of recurrent urinary tract infection in female patients. efficacy of low-dose, thrice-weekly therapy with trimethoprim-sulfamethoxazole.thirty-two women with recurrent urinary tract infections were treated after eradication of existing infections with a mixture of 40 mg of trimethoprim and 200 mg of sulfamethoxazole thrice weekly at bedtime for six months. six preadolescents received one half this dose. during 21.3 cumulative patient-years of prophylaxis, one infection due to streptococcus faecalis and one due to a sulfamthoxazole-and trimethoprim-sensitive escherichia coli occurred--an infection incidence of 0.1 per patient-yea ...1979480642
[alteration of the normal intestinal flora in human sucklings within the last 20 years].analyses of the feces-flora and the feces-ph of breastfed infants and of infants nourished with commercial formulae (ki-na, milasan) performed since 20 years were evaluated. in both regimens decreasing numbers of bifidobacteria could be remarked. the dominating position of this groups of bacteria was limited more and more. since 1971 the bifidobacterium biotype, characteristic of feces of breastfed infants could be proved no more. simultaneously germs of the e. coli-group and neonmycine-resisten ...1979481569
[primary renal actinomycosis].a case of renal actinomycosis, treated by nephrectomy, in a 41 year-old male, is reported. the clinical diagnosis, to which urography and renal arteriography lent support, was renal anthrax. the pus being sterile on conventional seeding, the investigations were directed towards the finding of characteristic mycelium. five months after nephrectomy a cerebral abscess developed and the patient died. although in the cerebral pus only b. proteus and coagulase-positive staphylococci were found, the ac ...1979482667
[germinal change and its significance in the hospital (author's transl)].to receive objective informations about clinically supposed difference of bacteria spectrum in hospital infections within the last 20 years, we made statistical comparatively investigations between varying periods and in different fields. in the whole material of the medical department we found an increase of proteus, pseudomonas and klebsiella (p = 0,01%) and an increase of candida while staphylococci, streptococci, pneumococci, clostridium and meningococci have clearly decreased. in the depart ...1979484110
[identification and antibiotic-resistance of microbial strains isolated from urinary infections (author's transl)].during the year 1977, 1491 urine samples were taken from patients living in the "alta valle del tevere" (umbria, italy). the isolated microorganisms were examined and tested against 15 antibiotics. 535 samples (35.88%) were free from bacteria. among the 1095 isolates, 52.42% were gram-negative, 46.85% gram-positive, and only 0.73% fungi. the genera citrobacter, escherichia, proteus, pseudomonas, enterobacter, klebsiella, staphylococcus and enterococcus were identified. a high proportion of strai ...1979485594
aerobic and anaerobic bacterial flora in semen from fertile and infertile groups of men.semen samples were collected by masturbation under asceptic conditions from men who had sired children within the past 6 mo (group a) and asymptomatic men attending an infertility clinic who had not sired children and whose wives were asymptomatic for infertility (group b). these 109 semen samples were analyzed and cultured for isolation of aerobic and anerobic organisms. overall, 68% of the specimens had positive bacterial cultures: 54% of the samples from group a were positive and 73% from gro ...1979485650
fournier's gangrene.twenty-five cases of gangrene of the scrotum and penis have been analysed. the anterior scrotum or the whole scrotum were the areas most frequently involved. the results of seminal analyses showed marked oligozoospermia during the infective period. haemolytic streptococcus was the most common organism. the aetiology of the disease is reviewed and "infective gangrene of the scrotum and penis" is considered to be a more suitable diagnostic label than fournier's gangrene.1979466010
[role of kidney function in the pharmacokinetics of a new semisynthetic penicillin (sulbenicillin)]. 1979487714
antibiotics in pyelonephritis. 1979467068
[results of the use of a new aminoglycoside antibiotic, sisomicin, in gram negative bacterial respiratory infections].clinical efficacy of a new aminoglycoside antibiotic, sisomicin, was evaluated in 14 patients with acute chest infections (12 cases with pneumonia and 2 with bronchitis). they were selected taking into account the isolation of sisomicin-sensitive gram-negative bacilli in a sputum specimen collected prior to therapy. local predisposing factors were present in 4 patients whereas general predisposing factors were present in 4 patients whereas general predisposing factors were recognizable in 9. kle ...1979492551
[relationship of the dna content in the nuclei of amoeba proteus to the food regimen].the relative dna content of isolated amoeba proteus nuclei has been measured by cytofluorometry. with the amoeba strain studied, the generation time is roughly equal to 48 hours at 25 degrees c, and with the presence of food in the medium. after the synchronous divisions, amoebae were maintained in the medium either with or without food organisms (tetrahymena pyriformis). dna contents in the nuclei of both the amoebae groups were measured within 4 and 48 hours after division. before 16 hours, th ...1979494392
experimental embolization in kidneys: tissue concentration of 7 dogs renal arterial embolization was performed using the seldinger technique and an inflatable swan ganz balloon catheter. methyl methacrylate and butyl-2-cyanoacrylate were injected. 6 months later, the tissue concentration of cefazolin was measured in the embolized and contralateral kidneys and in serum 2 h after a short infusion of 1 h cefazolin. the concentrations in serum and homogenized kidney tissue were determined by means of the agar gel diffusion method. angiography showed no vess ...1979494438
o antigen grouping of morganella morganii (proteus morganii) by slide agglutination.antisera were prepared against morganella morganii (proteus morganii) type strains from the scheme described by rauss et al. (acta microbiol. acad. sci. hung. 22:315--321, 1975) and raus and vörös (acta microbiol. acad. sci. hung. 6:233--248, 1959; acta microbiol. acad. sci. hung. 14:195--198, 1967). the specificities of the somatic (o) antigens were studied using the passive hemagglutination and slide agglutination techniques. previously unreported interstrain relations were observed, and o gro ...1979500798
a ten-year retrospective study of sepsis in severely burned patients treated with or without silver sulfadiazinate.three groups of extensive burn patients of the surgical intensive care unit (icu) have been compared: group i: twenty patients, who were treated locally without silver sulfadiazinate (1968-1970); group ii: the twenty first patients topically treated with silver sulfadiazinate (1970-1972); group iii: twenty similarly treated patients, with silver sulfadiazinate, six years later (1976-1977). the groups are statistically comparable. all bacteriological samples were computerized; the chi-square meth ...1979451485
clinical and radiological features of neonatal septic arthritis.fourteen neonates (first 28 days of life) with septic arthritis were admitted into the neonatal unit of the university of benin teaching hospital over a three year period. the incidence was 6.1 per 1000 admissions. eight were fullterm, three preterm and two low-birthweight babies. severe constitutional symptoms consisting of fever (temp. 39 degrees c), abdominal distension and jaundice were uniformly present. the aetiologic agents included staphylococcus aureus (6), proteus mirabilis (2), and b ...1979505551
in-vitro activities of cefamandole and cephalothin against 1,881 clinical isolates. a multi-center use of an agardilution technic, 1,881 clinical isolates were tested against cefamandole and cephalothin. the isolates represented 18 genera, recovered in five geographically separate centers within the united states. the majority of strains were susceptible (mics less than or equal to 8 micrograms/ml) to both drugs. cefamandole showed greater activity against most of the bacterial pathogens. enterococci, serratia spp., and acinetobacter spp. were resistant to both drugs. cephalothin was more ...1979506998
in vitro activity of ly127935.the activity of ly127935, a beta-lactam antibiotic of novel structure, was studied in vitro against facultative gram-negative bacilli, staphylococcus aureus, and bacteroides fragilis. the strains were recent clinical isolates, many of which were relatively resistant to other antibiotics. ly127935 exhibited striking activity against escherichia coli, klebsiella pneumoniae, enterobacter sp., proteus sp., serratia marcescens, and b. fragilis with median minimum inhibitory concentrations of less tha ...1979507785
calcium distribution in amoeba proteus.a preliminary investigation of the distribution of cellular calcium in amoeba proteus was undertaken. total cellular calcium under control conditions was found to be 4.59 mmol/kg of cells. when the external ca++ concentration is increased from the control level of 0.03 to 20 mm, a net ca++ influx results with a new steady-state cellular calcium level being achieved in integral of 3 h. at steady state the amount of calcium per unit weight of cells is higher than the amount of calcium per unit wei ...1979512628
sucrose uptake by pinocytosis in amoeba proteus and the influence of external calcium.the relationship between ca++ and pinocytosis was investigated in amoeba proteus. pinocytosis was induced with 0.01% alcian blue, a large molecular weight dye which binds irreversibly to the cell surface. the time-course and intensity of pinocytosis was monitored by following the uptake of [3h]sucrose. when the cells are exposed to 0.01% alcian blue, there is an immediate uptake of sucrose. the cells take up integral of 10% of their initial volume during the time-course of pinocytosis. the durat ...1979512629
[experience with cefuroxime in pediatric field (author's transl)].having resistance to beta-lactamase-producing strains and showing resistance to not only cephalosporin resistant strains of e. coli and klebsiella but also to citrobacter, proteus and enterobacter, cefuroxime (cxm) was used in pediatric field for both fundamental and clinical studies. cxm was found to be a useful antibiotic in views of high clinical efficacy rate obtained and no side effect noted. as for the dose, the single dose of 25 mg/kg achieved sufficient blood levels. also in view of good ...1979513298
[comparison of the multiplication of vibrio cholerae bacteria, proteus biotype, in a liquid nutrient medium under gamma irradiation and dilution of the cell suspensions]. 1979515375
[comparative clinical, bacteriological and pathohistological studies of the sex organs of infertile cows].investigations were performed with materials from 39 cows divided into two groups: i -- internal sexual organs of 29 cows slaughtered because of infertility; and ii -- biopsy material from 10 cows that showed symptomies sterility. the same material was studied microbiologically and histopathologically by routine methods. the material was taken from the cervix, the uterus, and the horns. bacteriologically, the presence was established of str. uberis. e. coli, str. dysgalactiae, staph. et albus et ...1979516444
alafosfalin, a new inhibitor of cell wall biosynthesis: in vitro activity against urinary isolates in japan and potentiation with beta-lactams.a new phosphonopeptide, alafosfalin, was evaluated for in vitro antibacterial activity and for synergism with beta-lactams, using 475 japanese clinical isolates from urinary tract infections. alafosfalin was found to be highly active against escherichia coli and moderately active against serratia, klebsiella, enterobacter, and citrobacter, but less active against gram-positive organisms than were beta-lactams such as cephazolin or ampicillin and inactive against indole-positive proteus, pseudomo ...1979518073
assay of serum tobramycin levels with the bactec 460.serum tobramycin levels of synthetic and patient specimens were determined by the bactec 460. the results were compared with those obtained from the same specimens by radioimmunoassay. these studies suggest that assays performed by either method should be run in duplicate or triplicate to achieve maximum accuracy. the studies also suggest that results obtained by the bactec method are at least as reliable as those obtained by the radioimmunoassay method.1979518075
[changes in the bacterial flora of patients under antineoplastic treatment].the bacterial flora of the skin from different anatomical sites on cancer patients and a control group of medical personnel was examined. this was done to ascertain if antineoplastic therapy was able to change the pattern of microbial flora of patients and to provide a control for possible infectious complications. the results show that in the control group bacterial flora was normal and the antineoplastic treatment did not succeed in changing the bacterial pattern in the skin of patients deeply ...1979518758
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