PMID(sorted descending)
phytochemical screening and antibacterial activities of vernonia ambigua, vernonia blumeoides and vernonia oocephala (asteraceae).some vernonia species (vernonia ambigua, vernonia blumeoides and vernonia oocephala) used in northern nigerian traditional medicine, were subjected to phytochemical screening using standard procedures. the antibacterial activity using the disc diffusion method as outlined by the nccls was carried out on klebsiella pneumoniae, streptococcus pyogenes, staphylococcus aureus, corynbacterium ulcerans, methicillin resistant staphylococcus aureus (mrsa), salmonella typhi, pseudomonas aeruginosa, shigel ...201121485703
bacteriologic and plasmid analysis of etiologic agents of conjunctivitis in lagos, nigeria.background: conjunctivitis, an inflammation of the conjunctiva, is one of the most common eye problems affecting all age groups in nigeria. a better understanding of its epidemiology and the antibiotic susceptibility of etiologic bacterial agents is crucial for the initiation of preventive and therapeutic measures. this study determined the distribution and patterns of bacterial infections in nigerian patients with conjunctivitis. antibiotic resistance patterns and the plasmid profiles of these ...201121484175
cold atmospheric plasma: a successful treatment of lesions in hailey-hailey disease. 201121482888
quantifying selective reporting and the proteus phenomenon for multiple datasets with similar bias.meta-analyses play an important role in synthesizing evidence from diverse studies and datasets that address similar questions. a major obstacle for meta-analyses arises from biases in reporting. in particular, it is speculated that findings which do not achieve formal statistical significance are less likely reported than statistically significant findings. moreover, the patterns of bias can be complex and may also depend on the timing of the research results and their relationship with previou ...201121479240
chronic suppurative otitis media in children of luanda, angola.aim:  evaluation of clinical characteristics, bacteriology and hearing in paediatric patients with and without chronic suppurative otitis media (csom) in luanda, angola. methods:  interview, clinical examination, ear-discharge culture, open air pure-tone audiometry and brainstem auditory-evoked potentials of 23 outpatients with csom and 23 controls in a paediatric hospital. results:  of the csom vs. control children, 35% vs. 26% had running water, 70% vs. 70% electricity, 64% vs. 0% hiv (p < 0.0 ...201121477130
inhibition of inos reduces the therapeutic effects of ozone in acute necrotizing pancreatitis: an in vivo animal study.abstract objective. previously, it was shown that ozone and s-methylthiourea (smt) treatments had ameliorative effects on experimental models of acute necrotizing pancreatitis (anp). it is possible that the combination of ozone and smt may be more effective than either therapy. therefore, we investigated the efficacy of combination therapy with ozone and smt in an experimental rat model of anp. material and methods. sprague-dawley rats were divided into five experimental groups. groups were desi ...201121463160
[chronic pyelonephritis and xanthogranulomatous pyelonephritis]. 201121458176
urease inhibitors as potential drugs for gastric and urinary tract infections: a patent review.introduction: urease is the enzyme that catalyzes the hydrolysis of urea, which is involved in serious infections caused by helicobacter pylori in the gastric tract, as well as proteus and related species in the urinary tract. the necessity to treat such infections has stimulated intensive studies on various groups of urease inhibitors. areas covered: patent literature on urease inhibitors with possible applications in medicine is reviewed in this paper. hydroxamic acids, phosphoramidates, urea ...201121457123
urine cultures from indwelling bladder catheters in nursing home patients: a point prevalence study in a swedish county.abstract objectives. to survey the bacterial flora and antibiotic resistance in urinary strains from patients with indwelling bladder catheters residing in nursing homes within a geographically defined region. material and methods. urine was sampled for culture from 163 catheter patients (126 men and 37 women) during a 2 week period in march 2010. susceptibility testing of the isolated bacteria was compared with all urinary strains (n = 9994) from hospitals and primary healthcare in the same geo ...201121452928
syndromes with focal overgrowth in infancy: diagnostic approach and surgical treatment.abstract syndromes with focal overgrowth are sporadic diseases and comprise proteus syndrome and congenital lipomatous overgrowth, vascular malformations, and epidermal naevi (clove) syndrome, and isolated hemihyperplasia. we describe 3 children classified according to standard criteria with dysregulated growth of various tissues that was excised, together with excess toes, and tumours. correct classification facilitates diagnosis and operations. interdisciplinary treatment and follow-up are rec ...201021446802
[practice management of chronic bacterial prostatitis with levofloxacin].the aim of this prospective observational study was to present relevant data on the efficacy and safety of levofloxacin in the treatment of chronic bacterial prostatitis (nih-ii) in the daily clinical routine of urologists in their practices. in total, 243 patients were treated, including 62 patients with a microbiologically confirmed diagnosis -based on expressed prostatic secretion (eps). the current evaluation is based on these patients. their median age was 53 years. the patients were treate ...201121445824
antimicrobial activity of organotin(iv) complexes with the ligand benzil bis(benzoylhydrazone) and 4,4'-bipyridyl as coligand.several methyltin(iv) and butyltin(iv) complexes with the ligand benzil bis(benzoylhydrazone) and 4,4'-bipyridyl as coligand were synthesised and characterized by elemental analysis and by ir, (1)h, (13)c and (119)sn nmr spectroscopies. some of them were also analyzed using single crystal x-ray diffraction. the title compounds were evaluated for their in vitro antimicrobial properties. all buthyltin complexes showed significant inhibition of gram positive bacteria, resulting bacillus subtilis, s ...201121443849
re: strategy to control catheter encrustation with citrated drinks: a randomized crossover study. a. khan, f. housami, r. melotti, a. timoney and d. stickler. j urol 2010; 183: 1390-1394. 201121439588
epidemiology of ciprofloxacin resistance and its relationship to extended-spectrum +¦-lactamase production in proteus mirabilis bacteremia.we evaluated the clinical features of ciprofloxacin-resistant proteus mirabilis bacteremia and risk factors for ciprofloxacin resistance.201121437168
correlation between antibiotic consumption and resistance of gram-negative bacteria causing healthcare-associated infections at a university hospital in taiwan from 2000 to 2009.this study investigated the correlation between antibiotic consumption and antimicrobial resistance in gram-negative bacteria causing healthcare-associated infections at a university hospital in taiwan from 2000 to 2009.201121436153
a bacillus proteus brain abscess. 192921433446
[correlation between histomorphometric changes and the type of aerobic bacteria isolated in chronic suppurative otitis media].bacterial flora is a very important factor in pathogenesis of chronic suppurative otitis media (csom) and significantly influences the type and intensity of osteolytic process. there are few histomorphometric investigations of middle ear mucosa in chronic otitis. the aim of this study was to identify aerobic bacteria responsible for chronic suppurative otitis media as well as their association with histomorphometric changes of middle ear mucosa.201121425618
[antimicrobial susceptibility of clinical isolates of aerobic gram-negative bacteria in 2006].we determined mics of antibacterial agents against 1280 clinical strains of aerobic gram-negative bacteria (19 genus or species) isolated at 16 japanese facilities in 2006. mics were determined using mostly broth microdilution method and antibacterial activity was assessed. strains producing extended-spectrum beta-lactamases (esbl) accounted for 3.7% of escherichia coli, 2.7% of klebsiella spp., and 11.4% of proteus spp. notably, 18.8% of proteus mirabilis was found to produce esbl higher than 1 ...201021425597
monitoring of multiple drug-resistant pathogens in a selected stretch of bay of bengal, india.the present work aims at identification of multiple drug-resistant pathogenic bacteria in a selected stretch, namely, puri on the bay of bengal, india. six stations at the coast of puri were selected and samples of water and sediment were collected during the winter of 2008 and 2009 for this study. thirty-eight pathogenic bacteria were isolated and identified from both the water and the sediment of 6 fixed stations (pu-1a, pu-1b, pu-2, pu-3, pu-4, and pu-5). the identified pathogens were escheri ...201121424669
an unusual initial presentation of proteus syndrome: macrosyndactyly.proteus syndrome is a complex disorder characterized by a wide variety of deformities including macrodactyly. in the present report, we present a case with complex macrosyndactyly in his hand. the patient was surgically treated. however, he admitted with lymphangiomas on his body during the follow-up period, leading to the diagnosis of proteus syndrome. this article discusses the differential diagnosis of proteus syndrome and the treatment methods used for macrodactyly along with the presentatio ...201121417989
antibiotic susceptibility pattern of urinary tract pathogens in ibadan, nigeria.urinary tract infections (uti) affect all age groups and occur in both hospitalized and non-hospitalized individuals and have serious impact on the socioeconomic life of the individual and the society, and also account for a large proportion of antibacterial drug consumption. treatment failure has been attributed to increasing resistance to common antibiotics, but there is paucity of data from this part of nigeria. this prospective study was carried out to determine the prevalence and antibiotic ...201021416786
nasal immunization with attenuated salmonella typhimurium expressing an mrpa-tetc fusion protein significantly reduces proteus mirabilis colonization in the mouse urinary tract.the development of effective strategies to prevent urinary tract infections (utis) has become an important goal in public health. proteus mirabilis is commonly associated with complicated utis and expresses several virulence factors, including mannose-resistant proteus-like (mr/p) fimbriae. here, a fusion protein formed from mrpa, the structural protein of mr/p fimbriae, and tetc, a non-toxic but highly immunogenic fragment of tetanus toxin, to be delivered by an attenuated salmonella typhimuriu ...201121415205
medical microbiologythe gram-negative bacilli of the genera escherichia, klebsiella, enterobacter, serratia, citrobacter,and proteus(table 26- 1) are members of the normal intestinal flora of humans and animals and may be isolated from a variety of environmental sources. with the exception of proteus, they are sometimes collectively referred to as the coliform bacilli because of shared properties, particularly the ability of most sp ...199621413290
pulmonary manifestations in proteus syndrome: pulmonary varicosities and bullous lung disease.we report on two patients with proteus syndrome (ps), with emphasis on its pulmonary manifestations. the first patient was a 6-year-old girl diagnosed with ps at 5 years of age. the pulmonary abnormalities first observed at age 3 years and included streaky densities with accentuated vascular markings detected by chest radiography. the patient had persistent abnormalities on follow-up chest radiographs. chest computed tomography (ct) scans showed diffuse pulmonary venous dilatations. the second p ...201121412980
ß-lactamase producing enterobacteria isolated from surveillance swabs of patients in a cardiac intensive care unit in rio de janeiro, brazil.there is a high incidence of infections caused by betalactamase-producing gram-negative microorganisms in brazil. these organisms are of clinical and epidemiological importance, since their mobile genetic elements facilitate cross-infection. the present study was conducted in sentinel rectal swabs from patients admitted to a cardiac surgery hospital in rio de janeiro, from january through december 2007, in a consecutive manner. the aim of the study was to characterize the genotype and phenotype ...201121412586
depression - the proteus of medicine.depression is discussed as a disease of antiquity with suitable contemporary references also. the prevalence of this disorder, which at a given time constitutes 121 millions world-wide is mentioned. among the types of depression, comorbid depression forms an important one. classical depression forms the visible part of the depression iceberg while somatic and other life contextual situation forms the submerged part. somatic manifestations per se do not carry diagnostic weightage unless the core ...200421408045
evolution and spread of a multidrug-resistant proteus mirabilis clone with chromosomal ampc-type cephalosporinases in europe.proteus mirabilis isolates obtained in 1999 to 2008 from three european countries were analyzed; all carried chromosomal ampc-type cephalosporinase bla(cmy) genes from a citrobacter freundii origin (bla(cmy-2)-like genes). isolates from poland harbored several bla(cmy) genes (bla(cmy-4), bla(cmy-12), bla(cmy-14), bla(cmy-15), and bla(cmy-38) and the new gene bla(cmy-45)), while isolates from italy and greece harbored bla(cmy-16) only. earlier isolates with bla(cmy-4) or bla(cmy-12), recovered in ...201121402851
in vitro activity of ceftaroline against gram-positive and gram-negative pathogens isolated from patients in canadian hospitals in 2009.the in vitro activities of ceftaroline and comparative agents were determined for a collection of the most frequently isolated bacterial pathogens from hospital-associated patients across canada in 2009 as part of the ongoing canward surveillance study. in total, 4,546 isolates from 15 sentinel canadian hospital laboratories were tested using the clinical and laboratory standards institute (clsi) broth microdilution method. compared with other cephalosporins, including ceftobiprole, cefepime, an ...201121402844
a case of disproportionate macrodactyly or a mild form of proteus syndrome? an interesting case.we present a 20-year-old malay male whom we believe has proteus syndrome, a rare congenital disorder of asymmetrical overgrowth of body tissues. there are fewer than 100 confirmed cases reported worldwide thus the clinical presentation and histopathological findings are of significance. our patient presented with an overgrown right small finger and subcutaneous purplish pigmentation over his left upper arm and chest since birth. his small finger gradually increased in size. he had no abnormaliti ...201021400985
evaluation of antimicrobial susceptibility for +¦-lactams against clinical isolates from 51 medical centers in japan (2008).this antimicrobial resistance surveillance study was performed in 51 medical centers in japan over an 11-year period. the susceptibilities of 4228 strains including escherichia coli (491 strains), klebsiella spp. (462 strains), enterobacter spp. (459 strains), citrobacter freundii (358 strains), indole-positive proteus spp. (386 strains), serratia spp. (443 strains), acinetobacter spp. (327 strains), pseudomonas aeruginosa (473 strains), oxacillin-susceptible staphylococcus aureus (481 strains), ...201121396543
new variant salmonella genomic island 1-u in proteus mirabilis clinical and food isolates from south china. 201121393148
cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids.some natural products consisting of the alkaloids yohimbine and vincamine (indole-type), scopolamine and atropine (tropane-type), colchicine (tropolone-type), allantoin (imidazolidine-type), trigonelline (pyridine-type) as well as octopamine, synephrine, and capsaicin (exocyclic amine-type); the flavonoid derivatives quercetin, apigenin, genistein, naringin, silymarin, and silibinin; and the phenolic acids namely gallic acid, caffeic acid, chlorogenic acid, and quinic acid, were tested for their ...201121391841
in vitro synthesis of biogenic amines by brochothrix thermosphacta isolates from meat and meat products and the influence of other microorganisms.twenty brochothrix thermosphacta strains tested for biogenic amines (bas) production, formed histamine (6.6-16.2 mg/kg) and tyramine (18.7-35.4 mg/kg) but neither putrescine nor cadaverine. six of the twenty strains were also investigated in respect of their influence on the synthesis of bas by escherichia coli, pseudomonas sp., proteus mirabilis and lactobacillus sakei. in pure culture escherichia coli produced all of the studied amines (histamine, tyramine, putrescine and cadaverine) with a to ...201121382674
[immunovac-vp-4 for prevention of acute respiratory diseases in children's communities].assessment of prophylactic effect of immunovac-vp-4 against acute respiratory diseases (ards) in collectives of children.201021381375
relationship between the camp levels in leukocytes and the cytokine balance in patients surviving gram negative bacterial pneumonia.lipopolysaccharide-stimulated leukocytes secrete proinflammatory cytokines including tumor necrosis factor-a and interleukin-12. over-activation of host defense systems may result in severe tissue damage and requires regulation. granulocyte colony-stimulating factor and interleukin-10 are candidate cytokines for inducing tolerance to lipopolysaccharide re-stimulation. we compared cytokines secreted by lipopolysaccharide-stimulated blood cells from patients who had survived gram negative bacteria ...201121373266
antimicrobial activity of acanthus ilicifolius (l.).the antimicrobial activity of alcoholic, butanolic and chloroform extracts of leaves and roots of the plant acanthus ilicifolius ware studied. ampicillin and clotrimazole were used as standard antibacterial and antifungal agents respectively. the result of the study revealed that the alcoholic extract and chloroform extract of leaves exhibited strong inhibitory action against bacillus subtilis, staphylococcus aureus, candida albicans, aspergillus fumigatus and aspergillus niger and moderate inhi ...200821369453
chemical composition and antimicrobial activity of the essential oil of the leaves of feronia elephantum (rutaceae) from north west karnataka.the essential oil of the leaves of feronia elephantum corr. was analyzed by gas chromatography and gas chromatography/mass spectrometry. the main constituents were beta-pinene (28.4%), z-anethole (22.1%), methyl chavicol (12.0%) and e-anethole (8.1%), among thirty-three identified compounds, which represented 92.6% of the total oil. the antimicrobial activity was tested against five gram-positive and eight gram-negative bacteria, and four fungi. the oil was active against micrococcus luteus (gra ...201121366066
confirmation of hiv-like sequences in respiratory tract bacteria of cambodian and kenyan hiv-positive pediatric patients.bacteria and yeasts isolated from respiratory tracts of 39 cambodian and 28 kenyan hiv-positive children were tested for the presence of hiv-1 sequences.201121358602
in vitro activity of ceftobiprole against frequently encountered aerobic and facultative gram-positive and gram-negative bacterial pathogens: results of the canward 2007-2009 study.the in vitro activity of ceftobiprole was evaluated against 15 011 clinical isolates obtained from patients in canadian hospitals between 2007 and 2009. all staphylococcus aureus were susceptible to ceftobiprole (mic(90)'s for methicillin-susceptible staphylococcus aureus and methicillin-resistant staphylococcus aureus of = 1 µg/ml and 2 µg/ml, respectively). ceftobiprole was active against penicillin-susceptible streptococcus pneumoniae (mic(90), = 0.06 µg/ml), penicillin-resistant streptococcu ...201121353964
broad-spectrum antimicrobial efficacy of peptide a3-apo in mouse models of multidrug-resistant wound and lung infections cannot be explained by in vitro activity against the pathogens involved.although the designer proline-rich antimicrobial peptide a3-apo has only modest activity against escherichia coli and acinetobacter baumannii in vitro, in mouse models of systemic and wound infections it shows superior efficacy compared with conventional antibiotics. in this study, the efficacy of a3-apo in several additional mouse models was investigated, including staphylococcus aureus wound infection, mixed klebsiella pneumoniae-a. baumannii-proteus mirabilis wound infection and k. pneumoniae ...201121353493
neurofibromatosis type 1 and the "elephant man's" disease: the confusion persists: an ethnographic study.during informal interviews in the course of an ethnographic study on intergenerational dialogue between individuals with neurofibromatosis and their parents, many members of canadian neurofibromatosis associations stated they continue to be told the condition that afflicts them or their children is the "elephant man's" disease. today, even though well established clinical criteria make it possible to diagnose and differentiate the two diseases, the confusion between nf1 and the disease of joseph ...201121347399
prevalence of pseudomonas aeruginosa in post-operative wound infection in a referral hospital in haryana, india.the objective of our study was to determine the prevalence of pseudomonas aeruginosa in the isolates of postoperative wound and its susceptibility pattern to commonly used antibiotics.201021346900
scalarane sesterterpenes from the sponge hyatella sp.five new sesterterpenes (7-11) along with six known compounds (1-6) were isolated from the sponge hyatella sp., collected off the coast of soheuksan-do, korea. spectroscopic analyses revealed these compounds as scalarane sesterterpenes with oxidized furan moieties (7-10) and a corresponding lactam (11). the compounds exhibited moderate cytotoxicity, antibacterial activity, and weak inhibitory activity against isocitrate lyase.201121341710
[nosocomial sinusitis in an intensive care unit: a microbiological study].nosocomial sinusitis is a common complication of patients in icus. its diagnosis is important, and early treatment is required to avoid serious complications such as pneumonia, sepsis, meningitis, and intracranial abscesses.201121340197
akara ogbomoso: microbiological examination and identification of hazards and critical control points.akara ogbomoso was examined toward the establishment of hazard analysis and critical control point (haccp). the akara was produced in residential buildings with the attendant consequence of contamination. there was ample growth of aerobes, coliforms, staphylococci, shigella and yeast/mold from the samples, water and cowpea pastes. microbial contaminations occur through the processing, which can be corrected through education by adopting good hygienic and manufacturing practices. the critical con ...201021339157
bacteremia in a multilevel geriatric hospital.bloodstream infection (bsi) is a major cause of morbidity and mortality in hospitals. bacteremia in the elderly remains a diagnostic as well as a therapeutic challenge to the clinician.201021333922
isolation of a selected microbial consortium capable of degrading methyl parathion and p-nitrophenol from a contaminated soil site.a bacterial consortium with the ability to degrade methyl parathion and p-nitrophenol, using these compounds as the only carbon source, was obtained by selective enrichment in a medium with methyl parathion. samples were taken from moravia, medellin; an area that is highly contaminated, owing to the fact that it was used as a garbage dump from 1974 to 1982. acinetobacter sp, pseudomonas putida, bacillus sp, pseudomonas aeruginosa citrobacter freundii, stenotrophomonas sp, flavobacterium sp, prot ...201121328125
[one-stage revision of knee endoprosthesis due to periprosthetic infection and klippel-trenaunay syndrome].we present the case of a patient with klippel-trenaunay syndrome (kts) who underwent a one-stage revision of an infected total knee arthroplasty. a detailed orthopedic description of kt is presented as well as a discussion on the implementation of one-stage or multi-stage revision following infections of total knee arthroplasty. due to vascular anomalies with severe coagulation problems, soft tissue swelling and increased risk of infection, surgical treatment of such patients presents a special ...201121327613
clinical, immunological and genetic features in taiwanese patients with the phenotype of hyper-immunoglobulin e recurrent infection syndromes (hies).hyper-immunoglobulin e recurrent infection syndromes (hies) have distinct features, with identified associated mutations of stat3, tyk2, and dock8. among 197 taiwanese patients with primary immunodeficiency on a referral-base of over 23 million inhabitants, stat3 (r382w and q469r) and dock8 mutations (exon 1-9 deletion) were identified in two patients each from six ad-hies and five ar-hies patients, respectively. aside from decreased th17 and memory b cells, characteristic facies and pneumatocel ...201121324546
production of biogenic amines by lactic acid bacteria and enterobacteria isolated from fresh pork sausages packaged in different atmospheres and kept under refrigeration.the occurrence of in vitro amino acid activity in bacterial strains associated with fresh pork sausages packaged in different atmospheres and kept in refrigeration was studied. the presence of biogenic amines in decarboxylase broth was confirmed by ion-exchange chromatography and by the presence of the corresponding decarboxylase genes by pcr. from the 93 lactic acid bacteria and 100 enterobacteria strains analysed, the decarboxylase medium underestimates the number of biogenic amine-producer st ...201121316866
thrombocytes are effectors of the innate immune system releasing human beta defensin-3.thrombocyte concentrate i.e. platelet-rich plasma (prp) has become a popular adjunct for many surgical procedures. it is believed to improve bone and soft tissue healing. recently antimicrobial effects of the autologous preparation were reported by several groups. in this study we investigated the antimicrobial effect of prp against gram-negative microbes which frequently cause severe complications in orthopaedic trauma surgery.201121310405
microbial burden of some herbal antimalarials marketed at elele, rivers state.herbal antimalarials still remain an alternative to our traditional communities who can not afford orthodox antimalarials. this study was aimed at investigating the microbial quality of six herbal antimalarials using standard microbiological methods. of the six preparations analyzed, "schnapps", palm wine and water were the media of preparation; the water base preparations recorded higher microbial load. the mean microbial load was 159.5 × 10(5) cfu/ml and 217.4 × 10(2)cfu/ml in water and alcoho ...200921304626
antibacterial activity of the indigenous earthworms lampito mauritii (kinberg) and perionyx excavatus (perrier).earthworms respond to microbial infection through cellular and humoral defense mechanisms such as antimicrobial protein secretions. most of the humoral defense proteins are synthesized in the skin itself.201121299431
expression and characterization of a second l-amino acid deaminase isolated from proteus mirabilis in escherichia coli.l-amino acid deaminases catalyze the deamination of natural l-amino acids. two types of l-amino acid deaminase have been identified in proteus species. one exhibits high levels of activity toward a wide range of aliphatic and aromatic l-amino acids, typically l-phenylalanine, whereas the other acts on a relatively narrow range of basic l-amino acids, typically l-histidine. in this study, we cloned, expressed, and characterized a second amino acid deaminase, termed pm1, from p. mirabilis kctc 256 ...201121298676
prevalence and phenotypic characterisation of carbapenem resistance in enterobacteriaceae bloodstream isolates in a tertiary care hospital in india. 201121295949
microbial evaluation and public health implications of urine as alternative therapy in clinical pediatric cases: health implication of urine therapy.cultural means of pediatric treatment during ill health is a mainstay in africa, and though urine has been known to contain enteric pathogens, urine therapy is still culturally applicable in some health conditions and also advocated as alternative therapy. the study therefore, is to evaluate the microbial contents and safety of urine.201021293739
ureaseurease is produced by numerous taxonomically diverse bacterial species, including normal flora and nonpathogens. also, urease has been demonstrated as a potent virulence factor for some species, including proteus mirabilis (51), staphylococcus saprophyticus (36), and helicobacter pylori (23). urease is central to h. pylori metabolism and virulence, is necessary for its colonization of the gastric mucosa, and is a potent immunogen that elicits a vigorous immune response. this enzyme is used for t ...200121290719
the free-radical damage theory: accumulating evidence against a simple link of oxidative stress to ageing and lifespan.recent work on a small european cave salamander (proteus anguinus) has revealed that it has exceptional longevity, yet it appears to have unexceptional defences against oxidative damage. this paper comes at the end of a string of other studies that are calling into question the free-radical damage theory of ageing. this theory rose to prominence in the 1990s as the dominant theory for why we age and die. despite substantial correlative evidence to support it, studies in the last five years have ...201121290398
chromosome-encoded ampc and ctx-m extended-spectrum ß-lactamases in clinical isolates of proteus mirabilis from korea.among 222 proteus mirabilis clinical isolates collected from 17 hospitals in korea in 2008, 28 (12.6%) and 8 (3.6%) isolates exhibited extended-spectrum ß-lactamase (esbl) and ampc phenotypes, respectively. the most common type of esbl gene identified by pcr and sequencing experiments was bla(ctx-m-14a) (n = 12). the bla(ctx-m-90) (n = 4), bla(ctx-m-15) (n = 3), bla(ctx-m-12) (n = 3), bla(ctx-m-2) (n = 2), bla(ctx-m-14b) (n = 1), bla(tem-52) (n = 5), and bla(shv-12) (n = 1) genes were also detec ...201121282448
influence of referral bias on the clinical characteristics of patients with gram-negative bloodstream infection.summaryreferral bias can influence the results of studies performed at tertiary-care centres. in this study, we evaluated demographic and microbiological factors that influenced referral of patients with gram-negative bloodstream infection (bsi). we identified 2919 and 846 unique patients with gram-negative bsi in a referral cohort of patients treated at mayo clinic hospitals and a population-based cohort of olmsted county, minnesota, residents between 1 january 1998 and 31 december 2007, respec ...201121281552
assessment of effectiveness and safety of ibicella lutea extract in the control of experimental proteus mirabilis urinary tract infection.proteus mirabilis is an important cause of complicated urinary tract infections (uti). like many other microorganisms, p. mirabilis has acquired resistance to many antibiotics. due to the serious effects associated with uropathogenic p. mirabilis and the problems related to the use of antibiotics, alternative strategies for its control must be developed. previously, we studied the effect of ibicella lutea extract, a south american indigenous plant, on in vitro uropathogenicity of p. mirabilis. w ...201021252462
plasmid-mediated quinolone resistance in expanded spectrum beta lactamase producing enterobacteriaceae in morocco.although independently acquired, plasmid-mediated quinolone resistance appears to be linked with extended-spectrum or ampc-type beta-lactamases. since no data are available in african countries, the prevalence of qnr genes at the university hospital ibn rochd, casablanca, morocco, was investigated.201021252459
enterobacterial microflora in infancy - a case study with enhanced validate pmeu (portable microbe enrichment unit) method for monitoring the composition and development of infantile intestinal enterobacterial microflora.201121249478
suprathel-antiseptic matrix: in vitro model for local antiseptic treatment?acetic acid is a traditional antiseptic agent that has been used for more than 6000 years. the main goal of this study was to demonstrate the suitability of suprathel (polymedics innovations gmbh, denkendorf, germany) in combination with various antiseptic agents to create an "antiseptic-matrix" especially designed for problematic microorganisms such as proteus vulgaris, acinetobacter baumannii, or pseudomonas aeruginosa, which are frequently associated with burns. the study was designed to test ...201121242734
treatment of endocarditis due to proteus species: a literature review.endocarditis due to proteus species is very rare. we report a case of endocarditis due to proteus mirabilis that was successfully treated with ampicillin and gentamicin, and review the treatment regimens of previously published cases of proteus endocarditis.201121237686
carijodienone from the octocoral carijoa multiflora. a spiropregnane-based steroid.two new steroids (1 and 2) and the known pregna-1,4,20-trien-3-one (3) have been isolated from the pacific octocoral carijoa multiflora. compound 1 possesses a novel spiropregnane-based steroidal skeleton. the photochemical transformation of 3 into 1 allowed the assignment of the absolute configuration at c-10 of 1. the antibacterial activities of compounds 1 and 3 were evaluated against a panel of bacterial strains.201121235217
idiopathic corporeal hemihypertrophy associated with hemihypertrichosis.the hemihypertrophy or hemihyperplasy is a rare congenital abnormality, characterized by an asymmetric growth of the limbs, the trunk, and the face or half of the entire body. it may be isolated or be part of several syndromes including beckwith-wiedemann syndrome, klippel-trenaunay-weber syndrome, silver-russell syndrome and proteus syndrome. in its isolated form, it is called idiopathic. the latter may be associated with several anomalies including dermatological and urogenital abnormalities w ...201121232734
the prevalence and bacteriology of asymptomatic bacteriuria among antenatal patients in nnamdi azikiwe university teaching hospital nnewi; south eastern nigeria.background: urinary tract infection in pregnancy leads to poor pregnancy outcome. diagnosis and treatment of asymptomatic bacteriuria markedly improves pregnancy outcome as well as reduce the incidence of acute pyelonephritis. objective: to determine the prevalence and bacteriology of asymptomatic bacteriuria among antenatal patients in our centre, and to know if routine screening will be justifiable. materials and methods: this was a prospective study carried out between april and august 2008. ...201021220855
antimicrobial activity of α-(2-hydroxy-2-methylpropyl)-ω-(2-hydroxy-3-methylbut-2-en-1-yl) polymethylene from caesalpinia bonducella (l.) flem.the compound, α-(2-hydroxy-2-methylpropyl)-ω-(2-hydroxy-3-methylbut-2-en-1-yl)polymethylene, isolated from ethyl acetate leaf extract of caesalpinia bonducella (l.) flem. was evaluated for antimicrobial activity against clinical isolates, proteus vulgaris, pseudomonas aeruginosa, klebsiella sp., staphylococcus citrus, staphylococcus aureus, escherichia coli, candida albicans and rhodotorula sp. using agar diffusion method. the compound exerted inhibitory zone at all concentrations and revealed t ...201021218063
characterization of the enterobacteriaceae community that developed during storage of minced beef under aerobic or modified atmosphere packaging conditions.the whole cell protein and macrorestriction analysis of dna of enterobacteriaceae isolates recovered from minced beef stored at 0, 5, 10 and 15 °c aerobically and under modified atmosphere packaging consisting of 40% co(2)-30% o(2)-30% n(2) in the presence (map+) and absence (map-) of oregano essential oil were studied. sodium dodecyl sulphate polyacrylamide gel electrophoresis (sds-page) profiles obtained from whole cell protein analysis of the enterobacteriaceae isolates revealed seven groups. ...201021216482
synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents.a series of new coumarin-based 1,2,4-triazole derivatives were designed, synthesized and evaluated for their antimicrobial activities in vitro against four gram-positive bacteria (staphylococcus aureus, mrsa, bacillus subtilis and micrococcus luteus), four gram-negative bacteria (escherichia coli, proteus vulgaris, salmonella typhi and shigella dysenteriae) as well as three fungi (candida albicans, saccharomyces cerevisiae and aspergillus fumigatus) by two-fold serial dilution technique. the bio ...201021215620
evaluation of antibacterial activity of belizean plants: an improved method.the influences of medium type, inoculum density, and a cold incubation on antimicrobial assay sensitivity were tested. the largest and most distinct zones were produced using nutrient agar and the 1/10 4 inoculum density for staphylococcus aureus and proteus mirabilis but a 1/10 12 inoculum density for pseudomonas aeruginosa and escherichia coli . the greatest number of zones were detected without cold incubation. using this method, eight plants from belize were screened for antibacterial activi ...200021214435
volatile compounds and antimicrobial and antioxidant activities of the essential oils of the needles of pinus densiflora and pinus investigate the volatile compounds and the antibacterial and antioxidant effects of the essential oils of pinus densiflora needles (epdn) and pinus thunbergii needles (eptn), the volatile compounds of steam-distilled essential oils were analysed by gas chromatography-mass spectrometry. antibacterial activities were analysed by performing disc-agar diffusion assay and determining the minimum inhibitory concentrations (mics) of the essential oils. antioxidant activities were analysed via radica ...201121213230
efficient secretion of biologically active chondroitinase abc from mammalian cells in the absence of an n-terminal signal peptide.proteoglycans carrying chondroitin sulfate side chains have been shown to fulfill important biological functions in development, disease, and signaling. one area of considerable interest is the functional importance of chondroitin sulfates as inhibitors of the regeneration of axonal projections in the mammalian central nervous system. in animal models of spinal cord injury, injections of the enzyme chondroitinase abc from the bacterium proteus vulgaris into the lesion site leads to degradation o ...201121213020
neurofibromatosis type 1: persisting misidentification of the "elephant man" disease.during informal interviews in the course of an ethnographic study on intergenerational dialogue between individuals with neurofibromatosis and their parents, many members of canadian neurofibromatosis associations have stated that they continue to be told the condition that afflicts them or their children is "elephant man's disease." today, even though well-established clinical criteria make it possible to diagnose and differentiate the 2 diseases, the confusion between neurofibromatosis type 1 ...201121209351
screening of bloodborne pathogens and antimicrobial susceptibility testing among cancer screen bloodborne pathogens and test for antimicrobial susceptibility among patients with different types of cancer.201021198306
pan-susceptible proteus mirabilis septicemia in a patient multicolonized by pan-resistant bacteria. 201021193275
antimicrobial activity of erythromycin and clarithromycin against clinical isolates of escherichia coli, staphylococcus aureus, klebsiella and proteus by disc diffusion method.fifty clinical isolates comprising of escherichia coli, staphylococcus aureus, klebsiella and proteus were collected from different local pathological laboratories and their resistant pattern against two well known macrolides; erythromycin and clarithromycin were studied using disc diffusion method. klebsiella (41.67% against erythromycin and 58.34% against clarithromycin) and proteus (66.67% against erythromycin and clarithromycin) species were found to be more resistant against the studied mac ...201121190914
thyroid pathology in pten-hamartoma tumor syndrome: characteristic findings of a distinct entity.phosphatase and tensin homolog deleted on chromosome ten (pten)-hamartoma tumor syndrome (phts) is a complex disorder caused by germline inactivating mutations of the pten tumor suppressor gene. phts includes cowden syndrome (cs), bannayan-riley-ruvalcaba syndrome (brrs), and proteus-like syndromes. affected individuals develop both benign and malignant tumors in a variety of tissues, including the thyroid. this study is to better characterize and describe the thyroid pathology within the differ ...201021190448
the salmonella genomic island 1 is specifically mobilized in trans by the inca/c multidrug resistance plasmid family.the salmonella genomic island 1 (sgi1) is a salmonella enterica-derived integrative mobilizable element (ime) containing various complex multiple resistance integrons identified in several s. enterica serovars and in proteus mirabilis. previous studies have shown that sgi1 transfers horizontally by in trans mobilization in the presence of the inca/c conjugative helper plasmid pr55.201021187963
effect of neem extract against the bacteria isolated from marine fish.marine ornamental fishes are exceedingly valuable due to their high demand in domestic and international markets. there is a growing global interest to rear the fishes in captivity. but problem due to bacteria and fungi are the major hitch in captive condition. since, the use of antibiotics is banned, an attempt was made to ascertain in vitro assay of the neem leaves extract against the bacterial pathogens isolated from infected fishes. bacterial strains isolated from infected regions of the clo ...201021186711
asymptomatic bacteriuria among hiv positive pregnant women.the prognostic significance of asymptomatic bacteriuria resides in the observation that the prevalence is, relatively, high in persons with certain medical conditions, such as diabetes mellitus and pregnancy. this prevalence might, even, be higher in patients with human immunodeficiency virus infection. hence, this study set out to determine the prevalence of asymptomatic bacteriuria among symptom free and newly enrolled hiv infected pregnant women attending pmtct unit of antiretroviral clinic o ...201021178431
synthesis and antimicrobial activity of highly functionalised novel β-lactam grafted spiropyrrolidines and pyrrolizidines.a facile and one-pot synthesis of a series of novel spiropyrrolidines/pyrrolizidines with β-lactam substituent has been accomplished through 1,3-dipolar cycloaddition reaction of alkenyl esters derived from β-lactam aldehyde as dipolarophile with the dipole azomethine ylide derived from 1,2- and 1,3-diketones and secondary amino acids. the synthesized compounds were evaluated for antimicrobial activities and found to exhibit relatively good antibacterial activity at lower concentration against f ...201021177001
the nationwide study of bacterial pathogens associated with urinary tract infections conducted by the japanese society of chemotherapy.this study was conducted by the japanese society of chemotherapy and is the first nationwide study on bacterial pathogens isolated from patients with urinary tract infections at 28 hospitals throughout japan between january 2008 and june 2008. a total of 688 bacterial strains were isolated from adult patients with urinary tract infections. the strains investigated in this study are as follows: enterococcus faecalis (n = 140), escherichia coli (n = 255), klebsiella pneumoniae (n = 93), proteus mi ...201021174142
unexpected coregulator range for the global regulator lrp of escherichia coli and proteus mirabilis.the lrp/asnc family of transcription factors links gene regulation to metabolism in bacteria and archaea. members of this family, collectively, respond to a wide range of amino acids as coregulators. in escherichia coli, lrp regulates over 200 genes directly and is well known to respond to leucine and, to a somewhat lesser extent, alanine. we focused on lrp from proteus mirabilis and e. coli, orthologs with 98% identity overall and identical helix-turn-helix motifs, for which a previous study ne ...201021169483
territoriality in proteus: advertisement and aggression. 201021162556
[comparison of four phenotypic methods to detect extended-spectrum betalactamases].to compare the efficacy of four phenotypic methods for the identification of strains producing extended-spectrum β-lactamases isolated from urine cultures.201021152726
structure of the o-polysaccharide from the lipopolysaccharide of providencia alcalifaciens o-polysaccharide (o-antigen) was isolated by mild acid degradation of the lipopolysaccharide of providencia alcalifaciens o60 and studied by sugar and methylation analyses as well as (1)h and (13)c nmr spectroscopy, including 2d roesy and (1)h,(13)c hmbc experiments in d(2)o and a roesy experiment in a 9:1 h(2)o-d(2)o mixture to reveal correlations for nh protons. it was found that the polysaccharide is built up of linear pentasaccharide repeating units containing an amide of d-glucuronic aci ...201021146157
photodynamic therapy with a cationic functionalized fullerene rescues mice from fatal wound infections.fullerenes are under intensive study for potential biomedical applications. we have previously reported that a c60 fullerene functionalized with three dimethylpyrrolidinium groups (bf6) is a highly active broad-spectrum antimicrobial photosensitizer in vitro when combined with white-light illumination. we asked whether this high degree of in vitro activity would translate into an in vivo therapeutic effect in two potentially lethal mouse models of infected wounds.201021143031
a child with mental retardation and asymmetrical hypertrophy of limbs.a 5-year-old male child presented with progressively increasing asymmetrical overgrowth of limbs, hyperpigmentation on the right half of the body, and mental retardation since 9 months of age.201021132570
necrotising otitis externa: an unusual cause of cranial nerve palsy in a diabetic haemodialysis patient.we present an unusual case of necrotising otitis externa (noe) causing a lower motor neurone facial nerve palsy in a patient with diabetes mellitus and receiving maintenance haemodialysis for end-stage renal disease (esrd). pseudomonas aeruginosa is the most common pathogen isolated in noe, although our case involved the non-typical pathogens aspergillus flavus and proteus mirabilis. we discuss the need for diagnostic rigour and the importance of considering atypical infective pathology in patie ...201021125035
laboratory detection of extended-spectrum-beta-lactamase-producing enterobacteriaceae: evaluation of two screening agar plates and two confirmation techniques.the worldwide prevalence of extended-spectrum-beta-lactamase-producing esbl-producing enterobacteriaceae (esbl-e) is increasing, making the need for optimized detection techniques more urgent. in this study we investigated the performance of two esbl-e screening and two esbl-e confirmation techniques. in accordance with the dutch national guidelines (, a collection of 642 highly resistant enterobacteriaceae strains, as identified by vitek2, was used to test the performances of two scr ...201021123527
clinical aspects and genetic analysis of taiwanese patients with the phenotype of hyper-immunoglobulin e recurrent infection syndromes (hies).hyper-immunoglobulin e recurrent infection syndromes (hies) has characteristic features and identified mutations. this study investigated clinical features and causal candidate mutations in taiwanese patients with the hies phenotype on referral base over 23 million inhabitants.201021120687
ceftaroline activity against pathogens associated with complicated skin and skin structure infections: results from an international surveillance assess the spectrum and potency of ceftaroline, a novel anti-methicillin-resistant staphylococcal cephalosporin, against a 2008 surveillance collection of clinical isolates from patients in the usa and europe.201021115451
predation of human pathogens by the predatory bacteria micavibrio aeruginosavorus and bdellovibrio bacteriovorus.the focus of this study was to evaluate the potential use of the predatory bacteria bdellovibrio bacteriovorus and micavibrio aeruginosavorus to control the pathogens associated with human infection.201021114596
[occurrence of 16s rrna methylase arma producing enterobacteriaceae in a general hospital in warsaw, poland].resistance to gentamicin, amikacin and kanamycin was screened in 270 clinical isolates of enterobacteriaceae originated from april 19 to may 19, 2010 in a regular hospital in warsaw, poland. most of the isolated bacteria were considered pathogenic. nineteen isolates (7%) were simultaneously resistant to two or three of the tested aminoglycosides. mics of the three aminoglycosides ranged form 128 to 1024 mcg/ml for six isolates. these isolates were suspected to produce 16s rrna methylase. genes e ...201021114012
[epidemiological and bacteriological characteristics of uropathogen bacteria isolated in a pediatric environment].urinary tract infection (uti) in children is a grave pathology, which requires a fast and effective care. bacteriological and epidemiological data play a determining role in patient's care. we report a retrospective study, which spreads out from january 1st till august 31st, 2009, having concerned hospitalized children for urinary infection in pediatrics service of farhat hached teaching hospital in sousse. our series contained 51 children with a sex ratio of 0.76, an average age of 32 months. t ...201021111582
c-terminal fragment of amebin promotes actin filament bundling, inhibits acto-myosin atpase activity and is essential for amoeba migration.amebin [formerly termed as apabp-fi; sobczak et al. (2007) biochem. cell biol. 85] is encoded in amoeba proteus by two transcripts, 2672-nt and 1125-nt. a product of the shorter transcript (termed as c-amebin), comprising c-terminal 375 amino-acid-residue fragment of amebin, has been expressed and purified as the recombinant gst-fusion protein. gst-c-amebin bound both to monomeric and filamentous actin. the binding was ca(2+)-independent and promoted filament bundling, as revealed with the trans ...201021094125
[a modified rat model for infection-induced stone formation].to employ a newly modified rat model for infection-induced bladder stone formation.201021092517
translational independence between overlapping genes for a restriction endonuclease and its transcriptional regulator.most type ii restriction-modification (rm) systems have two independent enzymes that act on the same dna sequence: a modification methyltransferase that protects target sites, and a restriction endonuclease that cleaves unmethylated target sites. when rm genes enter a new cell, methylation must occur before restriction activity appears, or the host's chromosome is digested. transcriptional mechanisms that delay endonuclease expression have been identified in some rm systems. a substantial subset ...201021092102
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