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Microbiology of the chronic suppurative otitis media.The aim of the study was to determine aetiological agents of chronic suppurative inflammation of the middle ear and their susceptibility to antibiotics, which could lead to better therapeutic decisions and consequently avoidance of appearance of resistance to specific antibiotics. Most frequently isolated agents were Staphylococcus aureus (30.6%), Pseudomonas aeruginosa (22.4%), Klebsiella spp. (10.6%) and Proteus spp. (7.1%). None of the isolates were resistant to ciprofloxacin. High sensitivit ...201121849954
predictors of surgical site infections of the abdomen in lagos, nigeria.the issue of nosocomial infection constitute a significant burden on any health care facility particularly in resource constrained centers of many developing countries.201121913509
Participation of mast cells in chronic otitis media.In the pathogenesis of chronic otitis media (COM), much attention is paid to the molecular mechanisms of local inflammatory reactions in which mast cells (MCs) may be involved due to their role not only in allergic but also inflammatory processes. The aim of this study was to assess the density of mast cells in chronic otitis media in relationship to different clinical courses of COM, bacterial infections and types of disease. The MCs expression was measured immunohistochemically in paraffin-emb ...201122038229
dissemination of the rmtb gene carried on incf and incn plasmids among enterobacteriaceae in a pig farm and its environment.to investigate the prevalence and characterization of 16s rrna methylase-producing bacteria in a pig farm and its environment in east china.201121852287
description and plasmid characterization of qnrd determinants in proteus mirabilis and morganella morganii.clin microbiol infect abstract: we investigated the presence of qnrc and qnrd among 756 non-replicate enterobacteriaceae isolated in italy, selected for being non-susceptible to fluoroquinolones and/or resistant to third-generation cephalosporins. four proteus mirabilis and one morganella morganii (0.66% of the total) presented a qnrd gene, located in a 2687-base-pair plasmid that was entirely sequenced. the plasmid is un-typable, and contains no known coding region other than qnrd. that the qnr ...201122192340
chromosomal integration and location on inct plasmids of the blactx-m-2 gene in proteus mirabilis clinical isolates.analysis of five ctx-m-2-producing proteus mirabilis isolates in japan demonstrated that bla(ctx-m-2) was located on the chromosome in four isolates and on inct plasmids in three isolates, including two isolates that also carried the gene on the chromosome. in all four isolates with chromosomal bla(ctx-m-2), isecp1 was responsible for the integration of the gene into the chromosome. three different sites in the p. mirabilis genomic sequence were utilized as integration sites.201122106217
radial and spiral stream formation in proteus mirabilis colonies.the enteric bacterium proteus mirabilis, which is a pathogen that forms biofilms in vivo, can swarm over hard surfaces and form a variety of spatial patterns in colonies. colony formation involves two distinct cell types: swarmer cells that dominate near the surface and the leading edge, and swimmer cells that prefer a less viscous medium, but the mechanisms underlying pattern formation are not understood. new experimental investigations reported here show that swimmer cells in the center of the ...201122219724
neurofibromatosis type 1: persisting misidentification of the "elephant man" disease.during informal interviews in the course of an ethnographic study on intergenerational dialogue between individuals with neurofibromatosis and their parents, many members of canadian neurofibromatosis associations have stated that they continue to be told the condition that afflicts them or their children is "elephant man's disease." today, even though well-established clinical criteria make it possible to diagnose and differentiate the 2 diseases, the confusion between neurofibromatosis type 1 ...201121209351
efficient secretion of biologically active chondroitinase abc from mammalian cells in the absence of an n-terminal signal peptide.proteoglycans carrying chondroitin sulfate side chains have been shown to fulfill important biological functions in development, disease, and signaling. one area of considerable interest is the functional importance of chondroitin sulfates as inhibitors of the regeneration of axonal projections in the mammalian central nervous system. in animal models of spinal cord injury, injections of the enzyme chondroitinase abc from the bacterium proteus vulgaris into the lesion site leads to degradation o ...201121213020
volatile compounds and antimicrobial and antioxidant activities of the essential oils of the needles of pinus densiflora and pinus thunbergii.to investigate the volatile compounds and the antibacterial and antioxidant effects of the essential oils of pinus densiflora needles (epdn) and pinus thunbergii needles (eptn), the volatile compounds of steam-distilled essential oils were analysed by gas chromatography-mass spectrometry. antibacterial activities were analysed by performing disc-agar diffusion assay and determining the minimum inhibitory concentrations (mics) of the essential oils. antioxidant activities were analysed via radica ...201121213230
prevalence and phenotypic characterisation of carbapenem resistance in enterobacteriaceae bloodstream isolates in a tertiary care hospital in india. 201121295949
expression and characterization of a second l-amino acid deaminase isolated from proteus mirabilis in escherichia coli.l-amino acid deaminases catalyze the deamination of natural l-amino acids. two types of l-amino acid deaminase have been identified in proteus species. one exhibits high levels of activity toward a wide range of aliphatic and aromatic l-amino acids, typically l-phenylalanine, whereas the other acts on a relatively narrow range of basic l-amino acids, typically l-histidine. in this study, we cloned, expressed, and characterized a second amino acid deaminase, termed pm1, from p. mirabilis kctc 256 ...201121298676
antibacterial activity of the indigenous earthworms lampito mauritii (kinberg) and perionyx excavatus (perrier).earthworms respond to microbial infection through cellular and humoral defense mechanisms such as antimicrobial protein secretions. most of the humoral defense proteins are synthesized in the skin itself.201121299431
influence of referral bias on the clinical characteristics of patients with gram-negative bloodstream infection.summaryreferral bias can influence the results of studies performed at tertiary-care centres. in this study, we evaluated demographic and microbiological factors that influenced referral of patients with gram-negative bloodstream infection (bsi). we identified 2919 and 846 unique patients with gram-negative bsi in a referral cohort of patients treated at mayo clinic hospitals and a population-based cohort of olmsted county, minnesota, residents between 1 january 1998 and 31 december 2007, respec ...201121281552
chromosome-encoded ampc and ctx-m extended-spectrum ß-lactamases in clinical isolates of proteus mirabilis from korea.among 222 proteus mirabilis clinical isolates collected from 17 hospitals in korea in 2008, 28 (12.6%) and 8 (3.6%) isolates exhibited extended-spectrum ß-lactamase (esbl) and ampc phenotypes, respectively. the most common type of esbl gene identified by pcr and sequencing experiments was bla(ctx-m-14a) (n = 12). the bla(ctx-m-90) (n = 4), bla(ctx-m-15) (n = 3), bla(ctx-m-12) (n = 3), bla(ctx-m-2) (n = 2), bla(ctx-m-14b) (n = 1), bla(tem-52) (n = 5), and bla(shv-12) (n = 1) genes were also detec ...201121282448
the free-radical damage theory: accumulating evidence against a simple link of oxidative stress to ageing and lifespan.recent work on a small european cave salamander (proteus anguinus) has revealed that it has exceptional longevity, yet it appears to have unexceptional defences against oxidative damage. this paper comes at the end of a string of other studies that are calling into question the free-radical damage theory of ageing. this theory rose to prominence in the 1990s as the dominant theory for why we age and die. despite substantial correlative evidence to support it, studies in the last five years have ...201121290398
idiopathic corporeal hemihypertrophy associated with hemihypertrichosis.the hemihypertrophy or hemihyperplasy is a rare congenital abnormality, characterized by an asymmetric growth of the limbs, the trunk, and the face or half of the entire body. it may be isolated or be part of several syndromes including beckwith-wiedemann syndrome, klippel-trenaunay-weber syndrome, silver-russell syndrome and proteus syndrome. in its isolated form, it is called idiopathic. the latter may be associated with several anomalies including dermatological and urogenital abnormalities w ...201121232734
carijodienone from the octocoral carijoa multiflora. a spiropregnane-based steroid.two new steroids (1 and 2) and the known pregna-1,4,20-trien-3-one (3) have been isolated from the pacific octocoral carijoa multiflora. compound 1 possesses a novel spiropregnane-based steroidal skeleton. the photochemical transformation of 3 into 1 allowed the assignment of the absolute configuration at c-10 of 1. the antibacterial activities of compounds 1 and 3 were evaluated against a panel of bacterial strains.201121235217
treatment of endocarditis due to proteus species: a literature review.endocarditis due to proteus species is very rare. we report a case of endocarditis due to proteus mirabilis that was successfully treated with ampicillin and gentamicin, and review the treatment regimens of previously published cases of proteus endocarditis.201121237686
suprathel-antiseptic matrix: in vitro model for local antiseptic treatment?acetic acid is a traditional antiseptic agent that has been used for more than 6000 years. the main goal of this study was to demonstrate the suitability of suprathel (polymedics innovations gmbh, denkendorf, germany) in combination with various antiseptic agents to create an "antiseptic-matrix" especially designed for problematic microorganisms such as proteus vulgaris, acinetobacter baumannii, or pseudomonas aeruginosa, which are frequently associated with burns. the study was designed to test ...201121242734
enterobacterial microflora in infancy - a case study with enhanced enrichment.to validate pmeu (portable microbe enrichment unit) method for monitoring the composition and development of infantile intestinal enterobacterial microflora.201121249478
an unusual initial presentation of proteus syndrome: macrosyndactyly.proteus syndrome is a complex disorder characterized by a wide variety of deformities including macrodactyly. in the present report, we present a case with complex macrosyndactyly in his hand. the patient was surgically treated. however, he admitted with lymphangiomas on his body during the follow-up period, leading to the diagnosis of proteus syndrome. this article discusses the differential diagnosis of proteus syndrome and the treatment methods used for macrodactyly along with the presentatio ...201121417989
monitoring of multiple drug-resistant pathogens in a selected stretch of bay of bengal, india.the present work aims at identification of multiple drug-resistant pathogenic bacteria in a selected stretch, namely, puri on the bay of bengal, india. six stations at the coast of puri were selected and samples of water and sediment were collected during the winter of 2008 and 2009 for this study. thirty-eight pathogenic bacteria were isolated and identified from both the water and the sediment of 6 fixed stations (pu-1a, pu-1b, pu-2, pu-3, pu-4, and pu-5). the identified pathogens were escheri ...201121424669
in vitro activity of ceftaroline against gram-positive and gram-negative pathogens isolated from patients in canadian hospitals in 2009.the in vitro activities of ceftaroline and comparative agents were determined for a collection of the most frequently isolated bacterial pathogens from hospital-associated patients across canada in 2009 as part of the ongoing canward surveillance study. in total, 4,546 isolates from 15 sentinel canadian hospital laboratories were tested using the clinical and laboratory standards institute (clsi) broth microdilution method. compared with other cephalosporins, including ceftobiprole, cefepime, an ...201121402844
evolution and spread of a multidrug-resistant proteus mirabilis clone with chromosomal ampc-type cephalosporinases in europe.proteus mirabilis isolates obtained in 1999 to 2008 from three european countries were analyzed; all carried chromosomal ampc-type cephalosporinase bla(cmy) genes from a citrobacter freundii origin (bla(cmy-2)-like genes). isolates from poland harbored several bla(cmy) genes (bla(cmy-4), bla(cmy-12), bla(cmy-14), bla(cmy-15), and bla(cmy-38) and the new gene bla(cmy-45)), while isolates from italy and greece harbored bla(cmy-16) only. earlier isolates with bla(cmy-4) or bla(cmy-12), recovered in ...201121402851
correlation between antibiotic consumption and resistance of gram-negative bacteria causing healthcare-associated infections at a university hospital in taiwan from 2000 to 2009.this study investigated the correlation between antibiotic consumption and antimicrobial resistance in gram-negative bacteria causing healthcare-associated infections at a university hospital in taiwan from 2000 to 2009.201121436153
epidemiology of ciprofloxacin resistance and its relationship to extended-spectrum +¦-lactamase production in proteus mirabilis bacteremia.we evaluated the clinical features of ciprofloxacin-resistant proteus mirabilis bacteremia and risk factors for ciprofloxacin resistance.201121437168
re: strategy to control catheter encrustation with citrated drinks: a randomized crossover study. a. khan, f. housami, r. melotti, a. timoney and d. stickler. j urol 2010; 183: 1390-1394. 201121439588
antimicrobial activity of organotin(iv) complexes with the ligand benzil bis(benzoylhydrazone) and 4,4'-bipyridyl as coligand.several methyltin(iv) and butyltin(iv) complexes with the ligand benzil bis(benzoylhydrazone) and 4,4'-bipyridyl as coligand were synthesised and characterized by elemental analysis and by ir, (1)h, (13)c and (119)sn nmr spectroscopies. some of them were also analyzed using single crystal x-ray diffraction. the title compounds were evaluated for their in vitro antimicrobial properties. all buthyltin complexes showed significant inhibition of gram positive bacteria, resulting bacillus subtilis, s ...201121443849
[practice management of chronic bacterial prostatitis with levofloxacin].the aim of this prospective observational study was to present relevant data on the efficacy and safety of levofloxacin in the treatment of chronic bacterial prostatitis (nih-ii) in the daily clinical routine of urologists in their practices. in total, 243 patients were treated, including 62 patients with a microbiologically confirmed diagnosis -based on expressed prostatic secretion (eps). the current evaluation is based on these patients. their median age was 53 years. the patients were treate ...201121445824
in vitro synthesis of biogenic amines by brochothrix thermosphacta isolates from meat and meat products and the influence of other microorganisms.twenty brochothrix thermosphacta strains tested for biogenic amines (bas) production, formed histamine (6.6-16.2 mg/kg) and tyramine (18.7-35.4 mg/kg) but neither putrescine nor cadaverine. six of the twenty strains were also investigated in respect of their influence on the synthesis of bas by escherichia coli, pseudomonas sp., proteus mirabilis and lactobacillus sakei. in pure culture escherichia coli produced all of the studied amines (histamine, tyramine, putrescine and cadaverine) with a to ...201121382674
cytotoxicity, antiviral and antimicrobial activities of alkaloids, flavonoids, and phenolic acids.some natural products consisting of the alkaloids yohimbine and vincamine (indole-type), scopolamine and atropine (tropane-type), colchicine (tropolone-type), allantoin (imidazolidine-type), trigonelline (pyridine-type) as well as octopamine, synephrine, and capsaicin (exocyclic amine-type); the flavonoid derivatives quercetin, apigenin, genistein, naringin, silymarin, and silibinin; and the phenolic acids namely gallic acid, caffeic acid, chlorogenic acid, and quinic acid, were tested for their ...201121391841
new variant salmonella genomic island 1-u in proteus mirabilis clinical and food isolates from south china. 201121393148
evaluation of antimicrobial susceptibility for +¦-lactams against clinical isolates from 51 medical centers in japan (2008).this antimicrobial resistance surveillance study was performed in 51 medical centers in japan over an 11-year period. the susceptibilities of 4228 strains including escherichia coli (491 strains), klebsiella spp. (462 strains), enterobacter spp. (459 strains), citrobacter freundii (358 strains), indole-positive proteus spp. (386 strains), serratia spp. (443 strains), acinetobacter spp. (327 strains), pseudomonas aeruginosa (473 strains), oxacillin-susceptible staphylococcus aureus (481 strains), ...201121396543
ß-lactamase producing enterobacteria isolated from surveillance swabs of patients in a cardiac intensive care unit in rio de janeiro, brazil.there is a high incidence of infections caused by betalactamase-producing gram-negative microorganisms in brazil. these organisms are of clinical and epidemiological importance, since their mobile genetic elements facilitate cross-infection. the present study was conducted in sentinel rectal swabs from patients admitted to a cardiac surgery hospital in rio de janeiro, from january through december 2007, in a consecutive manner. the aim of the study was to characterize the genotype and phenotype ...201121412586
pulmonary manifestations in proteus syndrome: pulmonary varicosities and bullous lung disease.we report on two patients with proteus syndrome (ps), with emphasis on its pulmonary manifestations. the first patient was a 6-year-old girl diagnosed with ps at 5 years of age. the pulmonary abnormalities first observed at age 3 years and included streaky densities with accentuated vascular markings detected by chest radiography. the patient had persistent abnormalities on follow-up chest radiographs. chest computed tomography (ct) scans showed diffuse pulmonary venous dilatations. the second p ...201121412980
nasal immunization with attenuated salmonella typhimurium expressing an mrpa-tetc fusion protein significantly reduces proteus mirabilis colonization in the mouse urinary tract.the development of effective strategies to prevent urinary tract infections (utis) has become an important goal in public health. proteus mirabilis is commonly associated with complicated utis and expresses several virulence factors, including mannose-resistant proteus-like (mr/p) fimbriae. here, a fusion protein formed from mrpa, the structural protein of mr/p fimbriae, and tetc, a non-toxic but highly immunogenic fragment of tetanus toxin, to be delivered by an attenuated salmonella typhimuriu ...201121415205
neurofibromatosis type 1 and the "elephant man's" disease: the confusion persists: an ethnographic study.during informal interviews in the course of an ethnographic study on intergenerational dialogue between individuals with neurofibromatosis and their parents, many members of canadian neurofibromatosis associations stated they continue to be told the condition that afflicts them or their children is the "elephant man's" disease. today, even though well established clinical criteria make it possible to diagnose and differentiate the two diseases, the confusion between nf1 and the disease of joseph ...201121347399
broad-spectrum antimicrobial efficacy of peptide a3-apo in mouse models of multidrug-resistant wound and lung infections cannot be explained by in vitro activity against the pathogens involved.although the designer proline-rich antimicrobial peptide a3-apo has only modest activity against escherichia coli and acinetobacter baumannii in vitro, in mouse models of systemic and wound infections it shows superior efficacy compared with conventional antibiotics. in this study, the efficacy of a3-apo in several additional mouse models was investigated, including staphylococcus aureus wound infection, mixed klebsiella pneumoniae-a. baumannii-proteus mirabilis wound infection and k. pneumoniae ...201121353493
in vitro activity of ceftobiprole against frequently encountered aerobic and facultative gram-positive and gram-negative bacterial pathogens: results of the canward 2007-2009 study.the in vitro activity of ceftobiprole was evaluated against 15 011 clinical isolates obtained from patients in canadian hospitals between 2007 and 2009. all staphylococcus aureus were susceptible to ceftobiprole (mic(90)'s for methicillin-susceptible staphylococcus aureus and methicillin-resistant staphylococcus aureus of = 1 µg/ml and 2 µg/ml, respectively). ceftobiprole was active against penicillin-susceptible streptococcus pneumoniae (mic(90), = 0.06 µg/ml), penicillin-resistant streptococcu ...201121353964
confirmation of hiv-like sequences in respiratory tract bacteria of cambodian and kenyan hiv-positive pediatric patients.bacteria and yeasts isolated from respiratory tracts of 39 cambodian and 28 kenyan hiv-positive children were tested for the presence of hiv-1 sequences.201121358602
chemical composition and antimicrobial activity of the essential oil of the leaves of feronia elephantum (rutaceae) from north west karnataka.the essential oil of the leaves of feronia elephantum corr. was analyzed by gas chromatography and gas chromatography/mass spectrometry. the main constituents were beta-pinene (28.4%), z-anethole (22.1%), methyl chavicol (12.0%) and e-anethole (8.1%), among thirty-three identified compounds, which represented 92.6% of the total oil. the antimicrobial activity was tested against five gram-positive and eight gram-negative bacteria, and four fungi. the oil was active against micrococcus luteus (gra ...201121366066
relationship between the camp levels in leukocytes and the cytokine balance in patients surviving gram negative bacterial pneumonia.lipopolysaccharide-stimulated leukocytes secrete proinflammatory cytokines including tumor necrosis factor-a and interleukin-12. over-activation of host defense systems may result in severe tissue damage and requires regulation. granulocyte colony-stimulating factor and interleukin-10 are candidate cytokines for inducing tolerance to lipopolysaccharide re-stimulation. we compared cytokines secreted by lipopolysaccharide-stimulated blood cells from patients who had survived gram negative bacteria ...201121373266
[nosocomial sinusitis in an intensive care unit: a microbiological study].nosocomial sinusitis is a common complication of patients in icus. its diagnosis is important, and early treatment is required to avoid serious complications such as pneumonia, sepsis, meningitis, and intracranial abscesses.201121340197
scalarane sesterterpenes from the sponge hyatella sp.five new sesterterpenes (7-11) along with six known compounds (1-6) were isolated from the sponge hyatella sp., collected off the coast of soheuksan-do, korea. spectroscopic analyses revealed these compounds as scalarane sesterterpenes with oxidized furan moieties (7-10) and a corresponding lactam (11). the compounds exhibited moderate cytotoxicity, antibacterial activity, and weak inhibitory activity against isocitrate lyase.201121341710
thrombocytes are effectors of the innate immune system releasing human beta defensin-3.thrombocyte concentrate i.e. platelet-rich plasma (prp) has become a popular adjunct for many surgical procedures. it is believed to improve bone and soft tissue healing. recently antimicrobial effects of the autologous preparation were reported by several groups. in this study we investigated the antimicrobial effect of prp against gram-negative microbes which frequently cause severe complications in orthopaedic trauma surgery.201121310405
production of biogenic amines by lactic acid bacteria and enterobacteria isolated from fresh pork sausages packaged in different atmospheres and kept under refrigeration.the occurrence of in vitro amino acid activity in bacterial strains associated with fresh pork sausages packaged in different atmospheres and kept in refrigeration was studied. the presence of biogenic amines in decarboxylase broth was confirmed by ion-exchange chromatography and by the presence of the corresponding decarboxylase genes by pcr. from the 93 lactic acid bacteria and 100 enterobacteria strains analysed, the decarboxylase medium underestimates the number of biogenic amine-producer st ...201121316866
clinical, immunological and genetic features in taiwanese patients with the phenotype of hyper-immunoglobulin e recurrent infection syndromes (hies).hyper-immunoglobulin e recurrent infection syndromes (hies) have distinct features, with identified associated mutations of stat3, tyk2, and dock8. among 197 taiwanese patients with primary immunodeficiency on a referral-base of over 23 million inhabitants, stat3 (r382w and q469r) and dock8 mutations (exon 1-9 deletion) were identified in two patients each from six ad-hies and five ar-hies patients, respectively. aside from decreased th17 and memory b cells, characteristic facies and pneumatocel ...201121324546
[one-stage revision of knee endoprosthesis due to periprosthetic infection and klippel-trenaunay syndrome].we present the case of a patient with klippel-trenaunay syndrome (kts) who underwent a one-stage revision of an infected total knee arthroplasty. a detailed orthopedic description of kt is presented as well as a discussion on the implementation of one-stage or multi-stage revision following infections of total knee arthroplasty. due to vascular anomalies with severe coagulation problems, soft tissue swelling and increased risk of infection, surgical treatment of such patients presents a special ...201121327613
isolation of a selected microbial consortium capable of degrading methyl parathion and p-nitrophenol from a contaminated soil site.a bacterial consortium with the ability to degrade methyl parathion and p-nitrophenol, using these compounds as the only carbon source, was obtained by selective enrichment in a medium with methyl parathion. samples were taken from moravia, medellin; an area that is highly contaminated, owing to the fact that it was used as a garbage dump from 1974 to 1982. acinetobacter sp, pseudomonas putida, bacillus sp, pseudomonas aeruginosa citrobacter freundii, stenotrophomonas sp, flavobacterium sp, prot ...201121328125
antimicrobial activity of erythromycin and clarithromycin against clinical isolates of escherichia coli, staphylococcus aureus, klebsiella and proteus by disc diffusion method.fifty clinical isolates comprising of escherichia coli, staphylococcus aureus, klebsiella and proteus were collected from different local pathological laboratories and their resistant pattern against two well known macrolides; erythromycin and clarithromycin were studied using disc diffusion method. klebsiella (41.67% against erythromycin and 58.34% against clarithromycin) and proteus (66.67% against erythromycin and clarithromycin) species were found to be more resistant against the studied mac ...201121190914
metallo-β-lactamases among enterobacteriaceae from routine samples in an italian tertiary-care hospital and long-term care facilities during 2008.the emergence of metallo-β-lactamase (mbl)-producing enterobacteriaceae is a serious public health concern. producers have been repeatedly isolated from patients and long-term care facility (ltcf) residents around bolzano, and we sought to assess their prevalence and clinical impact. all routine enterobacteriaceae isolates from a bolzano tertiary-care hospital and associated long-term care facilities in 2008 (n = 5500) were screened for mbls, with case details reviewed for the source patients. i ...201120345467
structure and serology of o-antigens as the basis for classification of proteus strains.this review is devoted to structural and serological characteristics of the o-antigens (o-polysaccharides) of the lipopolysaccharides of various proteus species, which provide the basis for classifying proteus strains to o-serogroups. the antigenic relationships of proteus strains within and beyond the genus as well as their o-antigen-related bioactivities are also discussed.201120305038
cadmium chloride exhibits a profound toxic effect on bacterial microflora of the mice gastrointestinal tract.cadmium (cd²(+)), a naturally occurring heavy metal, is an important environmental pollutant and a potent toxicant to bacteria. the gastrointestinal (gi) tract microflora has a marked capacity to cope with the increased load of ingested metals. however, heavy metals may have harmful effects on git microflora. under the conditions of experimental exposure to cadmium, changes in the population of intestinal microflora in healthy mice were examined. five experimental groups received 23 to 50 mg kg⁻ ...201120488844
effect of uropathogens on in vitro encrustation of polyurethane double j ureteral stents.polyurethane stents are used when there is an obstruction to the flow of urine. a majority of the patients with such stents are at the risk of urinary tract infection and salt encrustation. the present study is aimed at analyzing the in vitro encrustation of calcium oxalate and other salts in the presence of common uropathogens (e. coli and p. mirabilis) on films made from tecoflex(®), a commercial grade polyurethane. in the absence of uropathogens, sodium ions and ammonia favor calcium adsorpti ...201120517602
antimicrobial susceptibility of pediatric uropathogens in thrace, greece.the aim of this study was to investigate the bacterial pathogens involved in pediatric urinary tract infections (utis) in a tertiary general hospital located in the thrace province of northern greece over a 69-month period (1/2003 to 9/2008), and their antibiotic susceptibility patterns. a total of 622 episodes of utis in 508 children were identified. median age of all children was 16 months (range 1 month to 14 years). boys were significantly younger than girls (9 months vs. 24 months). escheri ...201120524067
aerobic bacteria from mucous membranes, ear canals, and skin wounds of feral cats in grenada, and the antimicrobial drug susceptibility of major isolates.in a 2-year period 54 feral cats were captured in grenada, west indies, and a total of 383 samples consisting of swabs from rectum, vagina, ears, eyes, mouth, nose and wounds/abscesses, were cultured for aerobic bacteria and campylobacters. a total of 251 bacterial isolates were obtained, of which 205 were identified to species level and 46 to genus level. a commercial bacterial identification system (api/biomerieux), was used for this purpose. the most common species was escherichia coli (n=60) ...201120627391
[etiology and sensitivity of uropathogens identified in uncomplicated lower urinary tract infections in women (aresc study): implications on empiric therapy].to determine the etiology and susceptibility of uropathogens identified in women with uncomplicated lower urinary tract infections (uti).201120889171
clinical and molecular epidemiology of extended-spectrum β-lactamase-producing escherichia coli and klebsiella pneumoniae in a long-term study from japan.the detection rates of extended-spectrum β-lactamase (esbl)-producing bacteria in japan are very low (∼5%) compared with those obtained worldwide. further, the current trend of these bacteria in japan is not known, and few studies with longitudinal observations have been reported. to obtain epidemiologic data on esbl-producing bacteria, their genotypic features, and their antibiotic resistance patterns in japan, we analyzed bacterial isolates from hospitalized patients at our institution over th ...201120859753
extreme lifespan of the human fish (proteus anguinus): a challenge for ageing mechanisms.theories of extreme lifespan evolution in vertebrates commonly implicate large size and predator-free environments together with physiological characteristics like low metabolism and high protection against oxidative damages. here, we show that the 'human fish' (olm, proteus anguinus), a small cave salamander (weighing 15-20 g), has evolved an extreme life-history strategy with a predicted maximum lifespan of over 100 years, an adult average lifespan of 68.5 years, an age at sexual maturity of 1 ...201120659920
risk factors for hospital-acquired urinary tract infection: a case-control study.the objective is to assess risk factors and microbiological aspects of hospital-acquired urinary tract infection (hauti) on six wards of a general regional hospital in serbia. a case-control study was nested within prospective cohort hautis study conducted from january 1 to december 31, 2007. three controls were identified for each patient with hauti, being chronologically the next three patients surveyed who did not develop hauti. the patients and controls were matched by sex and age (±5 years) ...201120848199
cajanol inhibits the growth of escherichia coli and staphylococcus aureus by acting on membrane and dna damage.in the present study, the mechanism of antibacterial activity of cajanol extracted from the roots of cajanus cajan (l.) millsp. towards escherichia coli (e. coli) and staphylococcus aureus (s. aureus) was investigated. the antibacterial activity of cajanol was evaluated towards six bacterial strains (staphylococcus epidermidis, staphylococcus aureus, bacillus subtilis, escherichia coli, proteus vulgaris, and pseudomonas aeruginosa) by the broth microdilution method. it showed strong antibacteria ...201120803417
electrical microcurrent to prevent conditioning film and bacterial adhesion to urological stents.long-term catheters remain a significant clinical problem in urology due to the high rate of bacterial colonization, infection, and encrustation. minutes after insertion of a catheter, depositions of host urinary components onto the catheter surface form a conditioning film actively supporting the bacterial adhesion process. we investigated the possibility of reducing or avoiding the buildup of these naturally forming conditioning films and of preventing bacterial adhesion by applying different ...201120686759
antibacterial activity of extracts from plants of central argentina--isolation of an active principle from achyrocline satureioides.the great increase in bacterial infections is fueling interest in the search for antibacterial products of plant origin. extracts obtained from 51 native and naturalized plants from central argentina were therefore evaluated for their in vitro inhibitory activity on pathogenic bacteria with the aim of selecting the most active ones as new sources of effective antibiotics. the susceptibility of reference and clinical strains of enterococcus faecalis, escherichia coli, proteus mirabilis, pseudomon ...201120645245
post-operative wound infection in salvage laryngectomy: does antibiotic prophylaxis have an impact?salvage laryngectomy carries a high risk of post-operative infection with reported rates of 40-61%. the purpose of this study was to analyse infections in our own patients and review the potential impact of our current antibiotic prophylaxis (ap). a retrospective analysis of infection in 26 consecutive patients between 2000 and 2010 undergoing salvage total laryngectomy (sl) following recurrent laryngeal cancer after failed radiotherapy or chemo-radiation was undertaken. the antibiotic prophylax ...201222274693
molecular analysis of the genus anoxybacillus based on sequence similarity of the genes recn, flaa, and ftsy.genome predictions based on selected genes would be a very welcome approach for taxonomic studies. we analyzed three genes, recn, flaa, and ftsy, for determining if these genes are useful tools for systematic analyses in the genus anoxybacillus. the genes encoding a dna repair and genetic recombination protein (recn), the flagellin protein (flaa), and gtpase signal docking protein (ftsy) were sequenced for ten anoxybacillus species. the sequence comparisons revealed that recn sequence similariti ...201222223049
coastal seawater bacteria harbor a large reservoir of plasmid-mediated quinolone resistance determinants in jiaozhou bay, china.diversity and prevalence of plasmid-mediated quinolone resistance determinants were investigated in environmental bacteria isolated from surface seawater of jiaozhou bay, china. five qnr gene alleles were identified in 34 isolates by pcr amplification, including qnra3 gene in a shewanella algae isolate, qnrb9 gene in a citrobacter freundii isolate, qnrd gene in 22 proteus vulgaris isolates, qnrs1 gene in 1 enterobacter sp. and 4 klebsiella spp. isolates, and qnrs2 gene in 1 pseudomonas sp. and 4 ...201222252223
a case of proteus syndrome with severe spinal canal stenosis, scoliosis, and thoracic deformity associated with tethered cord.proteus syndrome is a rare, sporadic, hamartomatous disorder manifesting with multifocal overgrowth of tissue. the features seem to develop most often during childhood. vertebral overgrowth with severe spinal canal stenosis is unusual, although scoliosis with abnormal vertebral bodies is one of the typical features of proteus syndrome. we report a case of proteus syndrome with severe spinal canal stenosis, scoliosis, cervical kyphosis, and thoracic deformity with airway obstruction because of as ...201222223075
study of plasmid-mediated extended-spectrum β-lactamase-producing strains of enterobacteriaceae, isolated from diabetic foot infections in a north indian tertiary-care hospital.abstract aim: this study evaluated the incidence and factors responsible for plasmid-mediated extended-spectrum β-lactamase (esbl) infection among patients with diabetic foot ulcer (dfu). subjects and methods: a prospective study was conducted on 162 dfu inpatients treated in a multidisciplinary-based diabetes and endocrinology center at jawaharlal nehru medical college of aligarh muslim university, aligarh, india, during the period of december 2008-march 2011. detailed history and patient's ...201222225456
proteus mirabilis interkingdom swarming signals attract blow flies.flies transport specific bacteria with their larvae that provide a wider range of nutrients for those bacteria. our hypothesis was that this symbiotic interaction may depend on interkingdom signaling. we obtained proteus mirabilis from the salivary glands of the blow fly lucilia sericata; this strain swarmed significantly and produced a strong odor that attracts blow flies. to identify the putative interkingdom signals for the bacterium and flies, we reasoned that as swarming is used by this bac ...201222237540
antimicrobial susceptibility of gram-negative pathogens isolated from patients with complicated intra-abdominal infections in south african hospitals (smart study 2004-2009): impact of the new carbapenem breakpoints.abstract background: the study for monitoring antimicrobial resistance trends (smart) follows trends in resistance among aerobic and facultative anaerobic gram-negative bacilli (gnb) isolated from complicated intra-abdominal infections (ciais) in patients around the world. methods: during 2004-2009, three centralized clinical microbiology laboratories serving 59 private hospitals in three large south african cities collected 1,218 gnb from complicated intra-abdominal infections (ciais) and t ...201222220506
french results of the aresc study: clinical aspects and epidemiology of antimicrobial resistance in female patients with cystitis. implications for empiric therapy.objective: uncomplicated cystitis is one of the most frequent community infections. we report the french results of the international aresc study on the clinical aspects, epidemiology, and antimicrobial susceptibility of uropathogens. patient and methods: female patients between 18 and 65 years of age, with symptoms of uncomplicated cystitis, were investigated clinically with urinalysis and urine culture. uropathogens were identified and their susceptibility was tested with nine antimicrobials. ...201222264668
Perturbation of FliL Interferes with Proteus mirabilis Swarmer Cell Gene Expression and Differentiation.Proteus mirabilis is a dimorphic, motile bacterium often associated with urinary tract infections. Colonization of urinary tract surfaces is aided by swarmer cell differentiation, which is initiated by inhibition of flagellar rotation when the bacteria first contact a surface. Mutations in fliL, encoding a flagellar structural protein with an enigmatic function, result in the inappropriate production of differentiated swarmer cells, called pseudoswarmer cells, under noninducing conditions, indic ...201222081397
Diversity and assessment of potential risk factors of Gram-negative isolates associated with French cheeses.The goal of this study was to identify at the species level a large collection of Gram-negative dairy bacteria isolated from milks or semi-hard and soft, smear-ripened cheeses (cheese core or surface samples) from different regions of France. The isolates were then assessed for two risk factors, antibiotic resistance and volatile and non-volatile biogenic amine production in vitro. In total, 173 Gram-negative isolates were identified by rrs and/or rpoB gene sequencing. A large biodiversity was o ...201222029922
effect of curcumin against proteus mirabilis during crystallization of struvite from artificial urine.we investigated the activity of curcumin against proteus mirabilis and the struvite crystallization in relation to urinary stones formation. in order to evaluate an activity of curcumin we performed an in vitro experiment of struvite growth from artificial urine. the crystallization process was induced by proteus mirabilis to mimic the real urinary tract infection, which usually leads to urinary stone formation. the results demonstrate that curcumin exhibits the effect against proteus mirabilis ...201221808656
Bacterial infections of Chinook salmon, Oncorhynchus tshawytscha (Walbaum), returning to gamete collecting weirs in Michigan.Herein, we describe the prevalence of bacterial infections in Chinook salmon, Oncorhynchus tshawytscha (Walbaum), returning to spawn in two tributaries within the Lake Michigan watershed. Ten bacterial genera, including Renibacterium, Aeromonas, Carnobacterium, Serratia, Proteus, Pseudomonas, Hafnia, Salmonella, Shewanella and Morganella, were detected in the kidneys of Chinook salmon (n = 480) using culture, serological and molecular analyses. Among these, Aeromonas salmonicida was detected at ...201222168454
development of an "early warning" sensor for encrustation of urinary catheters following proteus infection.biofilm formation in long-term urinary catheterized patients can lead to encrustation and blockage of urinary catheters with serious clinical complication. catheter encrustation stems from infection with urease-producing bacteria, particularly proteus mirabilis. urease generates ammonia from urea, and the elevated ph of the urine results in crystallization of calcium and magnesium phosphates, which block the flow of urine. the aim of this research is to develop an "early warning" silicone sensor ...201221954120
isolated macrodystrophia lipomatosa of the foot in a neonate: a case report.macrodystrophia lipomatosa characterized by enlargement of one or more fingers or toes with predominantly fibroadipose tissue can be part of an overgrowth syndrome such as proteus syndrome (biesecker, 2006) or cloves syndrome(sapp et al., 2007; alomari, 2009) or found as an isolated abnormality in an otherwise normal patient. it maybe present at birth or occur in early infancy with a progressive course. here, we report a case of macrodystrophia lipomatosa (mdl) diagnosed in the neonatal period i ...201221959860
Inhibition of escherichia coli and proteus mirabilis adhesion and biofilm formation on medical grade silicone surface.Silicone has been utilized extensively for biomedical devices due to its excellent biocompatibility and biodurability properties. However, its surface is easily colonized by bacteria which will increase the probability of nosocomial infection. In the present work, a hydrophilic antimicrobial carboxymethyl chitosan (CMCS) layer has been grafted on medical grade silicone surface pre-treated with polydopamine (PDA). The increase in hydrophilicity was confirmed from contact angle measurement. Bacter ...201221956834
Anti-bacterial studies on Hemigraphis colorata (Blume) H.G. Hallier and Elephantopus scaber L.To examine the ethanol, aqueous, chloroform, benzene, acetone and petroleum ether extracts of, Hemigraphis colorata (H. colorata) leaves and stem and Elephantopus scaber (E. scaber) leaves, root and flower for the presence of phyto-constituents and screened the anti-bacterial activity against the selected pathogens.201222182644
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