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alafosfalin, a new inhibitor of cell wall biosynthesis: in vitro activity against urinary isolates in japan and potentiation with beta-lactams.a new phosphonopeptide, alafosfalin, was evaluated for in vitro antibacterial activity and for synergism with beta-lactams, using 475 japanese clinical isolates from urinary tract infections. alafosfalin was found to be highly active against escherichia coli and moderately active against serratia, klebsiella, enterobacter, and citrobacter, but less active against gram-positive organisms than were beta-lactams such as cephazolin or ampicillin and inactive against indole-positive proteus, pseudomo ...1979518073
assay of serum tobramycin levels with the bactec 460.serum tobramycin levels of synthetic and patient specimens were determined by the bactec 460. the results were compared with those obtained from the same specimens by radioimmunoassay. these studies suggest that assays performed by either method should be run in duplicate or triplicate to achieve maximum accuracy. the studies also suggest that results obtained by the bactec method are at least as reliable as those obtained by the radioimmunoassay method.1979518075
[changes in the bacterial flora of patients under antineoplastic treatment].the bacterial flora of the skin from different anatomical sites on cancer patients and a control group of medical personnel was examined. this was done to ascertain if antineoplastic therapy was able to change the pattern of microbial flora of patients and to provide a control for possible infectious complications. the results show that in the control group bacterial flora was normal and the antineoplastic treatment did not succeed in changing the bacterial pattern in the skin of patients deeply ...1979518758
a review of providencia bacteremia in a general hospital, with a comment on patterns of antimicrobial sensitivity and use.six cases of providencia bacteremia occurring between 1969 and 1978 were reviewed. these cases represented 3% of the gram-negative bacteremias occurring at one hospital. all six cases of providencia bacteremia were secondary to urinary tract infection with p. stuartii, and in most the infection developed only shortly before the onset of bacteremia; in three cases the bacteremia developed immediately following manipulation of the urinary tract. patients with long-standing providencia infections d ...1979519613
susceptibility of aerobic and anaerobic gram-negative rods to cefoxitin and related compounds. 1979521267
o-serotyping providencia alcalifaciens.the o-serotyping scheme for providencia was tested on providencia alcalifaciens isolates collected mostly from two hospitals. the specificites of the somatic (o) antigens of p. alcalifaciens were found to be different from those of providencia stuartii, and separation of the providencia typing scheme to allow separate typing of each species led to more efficient typing. all but 4 of 86 isolates were typable. eighteen serotypes occurred among 53 typable isolates obtained from a pediatric hospital ...1979521478
application of o-serotyping in a study of providencia rettgeri (proteus rettgeri) isolated from human and nonhuman sources.a somatic (o) antigen serotyping scheme for providencia rettgeri (proteus rettgeri) was modified to exclude o-type strains recently reclassified as urea-positive providencia stuartii and was extended to include new serotypes to provide for serotyping on the basis of 93 o-antigens. isolates from two hospitals, five public health laboratories, and nonhuman sources (polluted water and frogs) were serotyped. the 112 isolates collected from a large general hospital over a 99-month period were distrib ...1979521481
[bacteriological study in acute pyelonephritis]. 1979524176
[use of pervomur for irrigation of purulent cavities].experimentally it has been shown that diluted pervomur (1:3) may be used for the intraoperation washing of the pleural cavity. the use of the diluted drug during the operations for acute purulent diseases of the lungs and pleura made it possible to prevent postoperative pleural empyemas and suppluration of soft tissue wounds in most patients.1979524667
evaluation of the bactec serum gentamicin assay.a radiometric assay for gentamicin was compared with an established radioimmunoassay protocol. the coefficients of variation for within-run, day-to-day, and overall runs were consistently higher for the radiometric method as compared with the radioimmunoassay. the coefficient of correlation for 84 patient sera tested by the two methods for gentamicin levels was 0.82. though less precise, the radiometric method was felt to be an acceptable means of determining gentamicin levels in laboratories wh ...1979526004
ly127935, a new beta-lactam antibiotic, versus proteus, klebsiella, serratia, and pseudomonas.one hundred eight clinical isolates of proteus, klebsiella, serratia, and pseudomonas spp. were tested in vitro against ly127935, cefamandole, cefoxitin, ticarcillin, carbenicillin, gentamicin, tobramycin, and amikacin by broth microdilution. the activities of ly127935 were greater than or equal to those of the other antimicrobial agents against proteus vulgaris, klebsiella pneumoniae, and serratia marcescens. inhibitions were greatest, however, for ticarcillin and carbenicillin versus proteus m ...1979526006
silver-resistant enterobacteriaceae from hospital patients.the inclusion of agar medium containing 0.5 mm agno3 in the hospital laboratory replicating system for routine antibiotic-susceptibility determinations resulted in identification of species of enterobacteriaceae (escherichia coli, enterobacter cloacae, klebsiella pneumoniae, proteus mirabilis, and citrobacter freundii) with silver resistance. since the study began in october, 1975, 11 in-hospital patients receiving silver sulfadiazine for burn wound prophylaxis have yielded silver-resistant bact ...1979526888
[antimicrobial activity of derivatives of 1,2,4-benzothiadiazine-1,1-dioxide. viii].the antimicrobial activity of a series of fluoro derivatives of benzothiadiazine and sulfonamides was studied. the compounds tested can be grouped as: a) 3-alkylmercapto derivatives of 6-trifluoromethyl-1,2,4-benzothiadiazine-1,1-dioxide (iii leads to vi); the 3-mercapto precursor (vii) and the related 3-picolinic salt (viii); b) 3-trifluoromethyl derivatives of 1,2,4-benzothiadiazine-1,1-dioxide and of its benzene substituted derivatives (ix leads to xvi); c) trifluoroacetylaminobenzenesulfonam ...1979527707
[comparative evaluation of two methods of determining the sanitary indicator bacteria of the genus proteus in food products]. 1979527824
comparative in vitro activity of ly 127935 (6059-s), seven cephalosporins, three aminoglycosides, carbenicillin, and ticarcillin.ly 127935 (6059-s), a new semi-synthetic beta-lactam antibiotic was tested simultaneously with 6 cephalosporins, 3 aminoglycosides, carbenicillin and ticarcillin against 398 clinical isolates of gram-negative bacilli and gram-positive cocci. many of the organisms were selected for study because of known resistance to one or more of the clinically available antibiotics tested. escherichia coli, klebsiella, serratia and providencia were susceptible to ly 127935. some resistant strains of enterobac ...1979528361
gunacin, a new quinone antibiotic from ustilago sp.in a screening program for antibiotics which were antagonized by cysteine, a strain, which was characterized as ustilago sp., was found to produce a new quinone antibiotic, gunacin. the molecular weight m+ = 348.084 determined by mass spectroscopy, corresponds to a molecular formula of c17h16o8. further spectroscopic data prove that gunacin is a new antibiotic. the antibiotic possesses a good inhibitory effect against mycoplasmas and gram-positive bacteria including multi-resistant strains. it a ...1979528380
chlorhexidine resistance and the lipids of providencia stuartii.the lipid composition of providencia stuartii has been shown to resemble closely that of proteus mirabilis. the ability of some pv, stuartii strains to survive exposure to high concentrations of the antiseptic chlorhexidine could not be explained in terms of differences in lipid content between sensitive and resistant strains. in addition, resistance could not be attributed to either reduced adsorption of the antiseptic or to its gross enzymic degradation.1979530092
[pediatric pharmacology of azlocilin (author's transl)].pharmacokinetic investigations of acylureido-penicillins azlocillin in newborns, infants and school shildren showed age dependend results. the differences were especially evident in a prolongation of the serum half-life to 2,56 hours in newborns compared to 0.94 hours in school children. on the basis of our pharmacokinetic results and of the dosages resulting from the data the antibiotic was used clinically in twenty eight patients with pseudomonas aeruginosa infections and one patient with a pr ...1979530731
bactericidal effect of combinations of antimicrobial drugs and antineoplastic antibiotics against gram-negative bacilli.six antineoplastic antibiotics showed little antibacterial activity against 28 strains of four species of gram-negative enteric bacteria. by using the cellophane transfer technique, combinations of these agents with 16 antibacterial drugs usually showed indifference. however, combinations of mitomycin c, especially with the aminoglycosides, were synergistic on strains of escherichia coli, proteus, and klebsiella pneumoniae. bleomycin, on the other hand, often showed antagonism on strains of e. c ...1979533257
antibacterial activities, nephrotoxicity, and ototoxicity of a new aminoglycoside, win 42122-2.win 42122-2 is a new aminoglycoside antibiotic obtained from a mutant strain of micromonospora purpurea. in vitro and in vivo comparisons of win 42122-2 with gentamicin and amikacin revealed that win 42122-2 generally was less active than gentamicin against pseudomonas and many enterobacteriacae, especially klebsiella and indole-negative proteus. against most gentamicin-susceptible isolates, win 42122-2 was more active than amikacin. gentamicin-resistant clinical isolates were usually resistant ...1979533261
in vitro activity of ly127935, a new 1-oxa cephalosporin, against aerobic gram-negative bacilli.a total of 434 clinical aerobic gram-negative bacillary isolates were tested against ly127935, a new 1-oxa cephalosporin, and compared with other cephalosporins, penicillins, and aminoglycosides by a broth microdilution technique. cefotaxime (hr756), a new semisynthetic cephalosporin, and ly127935 were more active, and showed lower minimum inhibitory concentrations (ranges, less than or equal to 0.12 to 2.0 micrograms/ml), than cefamandole, cefoxitin, and cefazolin against escherichia coli, kleb ...1979533267
antibacterial n-[omega, omega'-bis(alicyclic and aryl)-sec-alkyl]poly(methylene)triamine and -tetramine hydrochloride salts.a series of antibacterial n-(omega, omega'-(cycloalkyl, bicyclo[2.2.1]heptyl, and alkyl-substituted phenyl)-sec-alkyl]poly(methylene)triamine and -tetramine hydrochloride salts were synthesized in an effort to develop efficient, nonsystemic inhibitors, particularly for pseudomonas aeruginosa. in the 1,5,9-triazanonane group, 3 of 16 compounds were effective at 8--10 micrograms/ml against pseudomonads. efficiency appeared more dependent upon lipophilicity of the nitrogen substituent than other ch ...1979533889
immunochemical detection of n6-methyladenine in dna.antibodies to n6-methyladenosine were produced in rabbit by means of immunization with n6-methyladenosine coupled to bovine serum albumin via periodate oxidation. cross-reacting antibodies were removed by bovine serum albumin-sepharose and appropriate nucleoside-human serum albumin absorbents. nucleoside-specific antibodies were isolated by affinity chromatography of n6-methyladenosine-human serum albumin-sepharose. the specificity of the purified antibodies has been demonstrated by complement f ...1979534639
synthesis of a selective agar medium for yersinia enterocolitica.a new agar medium for isolation of yersinia enterocolitica was formulated based on growth studies which defined an optimum basal, and the evaluation of selective chemical agents, dyes, and antibiotics. the final formulation, designated cefsulodin-irgasan-novobiocin(cin) agar, provided quantitative recovery of 40 different strains of y. enterocolitica in 24 h using incubation at 32 degrees c or with 48 h of incubation at 22 degrees c. the medium was highly selective, especially against pseudomona ...1979540256
[cefadroxil: activity against an induced ascending urinary tract infection in the rat]. 1979540662
semisynthetic bicyclomycin derivatives: preparation and antibacterial evaluation.a number of semisynthetic bicyclomycin derivatives have been prepared by modifications at various sites of the molecule. the preparation, characterization and antimicrobial evaluation of the new compounds is described. in contrast to bicyclomycin itself, the new derivatives 48 and 58 are also active against proteus species. otherwise, the antibacterial potency of the bicyclomycin molecule was found to be very sensitive to structural changes.1979541264
bactericidal activity of cefadroxil, cephalexin, and cephradine in an in vitro pharmacokinetic model.cefadroxil (duricef, mead johnson and company), resembles cephalexin and cephradine in spectrum of antibacterial activity but differs in human pharmacokinetic properties. whether the latter are likely to affect activity in vivo was assessed by determining bactericidal activity against clinical isolates under conditions simulating the variation of drug concentration in the blood stream after an oral dose of 500 mg to adults. in this kinetic model, cefadroxil was more active than cephalexin or cep ...1979541265
medium for the presumptive identification of aeromonas hydrophila and enterobacteriaceae.a medium was devised for the rapid presumptive identification of aeromonas hydrophila. it also offered good differentiation of klebsiella, proteus, and other enteric species. mannitol fermentation, inositol fermentation, ornithine decarboxylation and deamination, indole production, motility, and h2s production from sodium thiosulfate and cysteine could be recorded in a single tube of the medium.1979543697
synergistic action between sisomicin and mezlocillin against gram-negative bacteria and staphylococcus aureus.the combined effect of sisomicin and 6-[(r)-2-[3-methylsulfonyl-2-oxo-imidazolidine-1-carboxamido]-2-phenyl-acetamido-a1-penicillanic acid sodium salt (mezlocillin, baypen) was studied against 50 bacterial strains, including pseudomonas aeruginosa, proteus spp. klebsiella-enterobacter, e. coli and staphylococcus aureus. no antagonism or indifference was detected with the strains studied. both antibiotics were synergistic against 62% of the strains, and partially synergistic against 38%. out of t ...1979543894
treatment with azlocillin in complicated urinary tract infections.20 patients, aged 18-84 years, with complicated urinary tract infections admitted to hospital were treated with 6-[(r)-2-(2-oxo-imidazolidine-1-carboxamido)-2-phenyl-acetamido]-penicillanic acid sodium salt (azlocillin, securopen) for 5 to 10 days. isolated bacteria were pseudomonas aeruginosa (14), proteus mirabilis (3), escherichia coli (2) and klebsiella spp. (1). serum concentrations and urine recovery were measured on the fifth day of treatment. the mean serum half-life was 1.85 h and the m ...1979543906
[microfloral study of bull seminal fluid stored at low temperatures].hundred twenty three samples of bull semen fluid frozen at 196 degrees c including 83 plastic ampules, 20 granules and 20 plastic straws obtained from the containers of the insemination stations of 10 farms from the sofia district were investigated. two hundred twelve strains were isolated and identified as: escherichia coli--25 strains, hafnia--16 strains, citrobacter, enterobacter and proteus mirabilis--9 strains of each. the remaining gram-negative genera and species were more rarely encounte ...1979545852
[antibacterial kinetics of fosfomycin (author's transl)].the authors studied, with the autobac machine, the kinetics of antibacterial activity of fosfomycin against staphylococcus aureus, streptococcus d' streptococcus pneumoniae, neisseria meningitidis, acinetobactor lwoffi, haemophilus influenzae, salmonella typhimurium, escherichia coli, proteus rettgeri, klebsiella pneumoniae, serratia marcescens and pseudomonas aeruginosa. a correlation appears between the kinetics of fosformycin antibacterial action and the microbial growth rate.1979547759
[in-vitro antimicrobial activity of 2 aminoglycoside antibiotics: tobramycin and gentamycin].it has been determined the in vitro antibacterial activity of two antibiotics on 409 bacterial stocks isolated from several pathologic materials and composed by e.coli,propeus,salmonellae,pseudomonas,staphylococcus aureus. the tobramicin has shown to have activity against all stocks of e.coli(82),pseudomonas aeruginosa (62) and salmonellae (21) and to have a better activity in comparison with gentamicin also against proteus and staphylococcus aureus.1979550883
[cefaclor in dermatological therapy (author's transl)].thirty patients suffering from bacteriogenic skin diseases were given cefaclor, in most cases simultaneously with classical external dermatological therapy. the results of therapy were satisfactory in 29 of the 30 patients. only in one relatively severe case of erysipelas did the disease continue to spread despite the daily doses of 3 x 500 mg of oral cefaclor prescribed by the dosage regimen. side-effects observed consisted of diarrhoea in one patient, and a transient slight increase of sgot or ...1979551090
in vitro activity of netilmicin and cefotaxime compared to that of other aminoglycosides.in vitro activity of netilmicin, cefotaxime, amikacin, dibekacin, gentamicin and tobramicin was compared against clinical isolates in antibiotic medium 3 at ph 7.1 and human plasma water at ph 7.8. except against pseudomonas aeruginosa the aminoglycosides were generally more active in plasma water than in broth. against p. aeruginosa higher concentrations were required to inhibit or kill the strain in the plasma water. cefotaxime was not tested against these organisms. against e. coli, k. pneumo ...1979552591
[antimicrobial effect of derivatives of 1,2,4-benzothiadiazin-1,1-dioxide. vii].series of alkyl derivatives of the following have been prepared: 5,7-dichloro- [compounds (ii leads to v)], 6-methyl- [compounds (vi leads to ix)] and 6-methoxy-3-mercapto-1,2,4-benzothiadiazine-1,1-dioxide [compounds (x leads to xiii)]. the products were tested for antimicrobial activity. studies were also made of the corresponding 3-mercapto precursors (xiv, xv, xvi) and the relative 3-picolinium salts (xvii, xviii, xix) and also of the 3-picolinium salts of 6-chloro-, 7-chloro- and 6,7-dichlo ...1979553823
[bacteriology of urinary infections in paraplegics (author's transl)].the aa. report the results of 300 urine cultures carried out on paraplegics hospitalized in the centro paraplegici of ostia since 1970 to the end of 1977. all the patients were catheterized. they found infections in the 73 to 92% of the examined cases in the different years. the most frequently isolated bacterial species in the years 1970, 1971, and 1972 were escherichia, staphylococcus and enterococcus, whereas were proteus, citrobacter, klebsiella and psuedomonas in the following years. they b ...1979554546
[a survey of italian hospitals on the frequency of the resistance of bacterial strains (author's transl)].the aa. delineate the limitations and practical difficulties encountered during a survey of the chemoantibiotic resistance of bacteria. data was collected from 12 italian hospitals, and 5,702 bacterial strains were confronted with 8 chemoantibiotics. the aa. suggest a model trough which data could be collected and computerized so as to set a correct policy for the use of antibiotics in hospitals.1979555524
[annual usage in a general hospital of antimicrobials and frequency of resistant bacterial strains (author's transl)].the data concerning annual usage in a general hospital and the frequency of resistant bacterial strains, isolated from patients with urinary tract's infection from 1975 to 1977 were collected and statistically processed. it was noticed that the year by year variation of resistance were mainly confined to e. coli and p. mirabilis. increasing resistance with time was found for e. coli with co-trimoxazole, p. mirabilis with cephaloridin and gentamicin, proteus indole-positive with rifampicin. reduc ...1979555536
[the role of enteric bacteria in childhood urinary tract infections and their in vitro response to antimicrobial agents].in this study, 154 cases of suspected bacterial urinary tract infection were examined bacteriologically. urine cultures yielded, e. coli in 84 patients citrobacter in 22 (c. freundii: 9, c. diversus: 9) proteus in 21 (p. vulgaris: 6, p. morgani: 4, p. rettgeri: 2. p. mirabilis: 4, lactose fermenting strains: 5), pseudomonas in 12 (p. aeruginosa: 5, other strains of pseudomonas: 7), klebsiella in 9 (k. aerogenes: 3, k. pneumonia: 6) and enterobacter in 6 patients (e. aerogenes: 1, e. cloacae: 5). ...1979555789
haloacetol phosphates as affinity labels for methylglyoxal synthase. 1977557320
humoral response in blood group p phenotype persons subjected to an avian environment.the avian environment contains among many antigens, the blood group substance p1-p1 antigen is present in certain enterobacteriaceae found in bird droppings. examples include enterobacter, klebsiella, e. coli, enterobacter haffniae and proteus. p2 persons exposed to the avian environment may develop anti-p1 activity. a greater percentage of precipitins to bird antigens was found in p2 than in p1 persons. in p1 persons seven out of twenty-eight (25%) had precipitins to bird droppings. in p2 perso ...1977560935
health problems of windowless henhouses.the working, health and zoohygiene problems of keeping chickens (45,000) in teroz type windowless houses on deep litter with controlled light regimen and hens (75,000) in cages were the subject of study for 3 years. the poultry was fed on factory-produced feedstuffs with the then permitted addition of ctc in amounts of 20 g/l tonne. except for the low intensity of illumination in the chicken house (10-1.1 1x) and with the observation of the prescribed technology, the working environment is favou ...1977565376
cefamandole---a review of chemistry and microbiology.the discovery of cephalosporin c and its conversion to 7-aminocephalosporanic acid (7-aca) are reviewed. the syntheses of cefamandole and three other injectable cephalosporins from 7-aca are described, and the antibiotic properties of the four drugs are compared. the microbiological potency of cefamandole is comparable to that of cephalothin, cephaloridine, and cefazolin against gram-positive organisms. cefamandole is the most potent of the four compounds against gram-negative bacteria. in addit ...1978565798
self-mutilation of the penis in c57bl/6n mice.a major cause of male reproductive failure in a c57bl/6n mouse production colony is self-inflicted mutilation of the penis. the extent of the damage ranged from loss of the distal end to loss of the entire penis. from january 1974 to august 1976, 645 adult male mice with mutilated penis were removed from this colony--where the monthly census was 9500 mice, mated 1 male to 4 females using a continuous mating system. on necropsy, it was observed that the substance blocking the urethra in the penil ...1978566826
comparison of four agar plating media with and without added novobiocin for isolation of salmonellae from beef and deboned poultry meat.four plating media, hektoen enteric (he), xylose-lysine deoxycholate (xld), tryptic soy-xylose-lysine (tsxl), and tryptic soy-brillant green (tsbg) agars with and without 10 mg of added novobiocin per ml, were evaluated for recovery of salmonella from roast beef and deboned turkey. colonies producing a reaction typical of h(2)s-positive salmonellae (alkaline with black centers) were picked. on the media without novobiocin, from 109 determinations on 75 samples, number of salmonellae found and fa ...1978569467
pharmacokinetics and safety of cefamandole in infants and children.cefamandole, a new cephalosporin antibiotic, has greater activity against common pathogens, including escherichia coli, haemophilus influenzae, and proteus (including indole-positive strains), than available cephalosporin drugs. we have evaluated the safety and pharmacokinetics of this drug in 30 infants and children. blood levels and urinary excretion of the drug were similar to those previously found in adults. the only side effects were mild and transient elevation of serum glutamic oxalaceti ...1978570372
r plasmids in gentamicin-tobramycin-carbenicillin-resistant nosocomial strains of proteus rettgeri and proteus morgani. 1978570994
effects of the actin-binding protein dnaase i on cytoplasmic streaming and ultrastructure of amoeba proteus. an attempt to explain amoeboid movement.microinjection of dnaase i, which is known to form a specific complex with g-actin, induces characteristic changes in cytoplasmic streaming, locomotion and morphology of the contractile apparatus of a. proteus. light microscopical studies show pronounced streaming originating from the uroid and/or the retracting pseudopods, which ceases 10--15 min after injection of dnaase i, at a time when ultrasctructural studies show that the actin filament system is very much reduced. these results suggest t ...1979573180
anaerobic fish spoilage by bacteria. i. biochemical changes in herring extracts. 1979573257
anaerobic fish spoilage by bacteria. ii. kinetics of bacterial growth and substrate conversions in herring extracts. 1979573258
nasopharyngeal autoflora in the process of influenza infection. 1979574884
[use of "konokonlit b", butyl-cyano-acrylate tissue adhesive, for caesarean section (author's transl)]."kanokonlit b", a butylic cyano-acrylate tissue adhesive, was applied to 60 patients with caesarean section to stabilise uterus sutures. severe postsurgical infection did not occur in any of the cases. evidence thus was produced to the high quality of the tissue adhesive, its tensile strength and its antibacterial properties to resist aerobic and anaerobic microorganisms. direct histotoxicity was negligible. the adhesive is recommended by the authors for wider use in obstetrical and gynaecologic ...1979575742
antimicrobial evaluation of cefoxitin: a new semisynthetic cephamycin. comparative studies with cefazolin and cefalotin.antimicrobial activity of 3-carbamoyloxymethyl-7-alpha-methoxy-7-[2-(2-thienyl)-acetamido]-3-cephem-4-carboxylic acid (cefoxitin), a new semisynthetic cephamycin antibiotic, was studied in comparison with that of cefazolin and cefalotin. cefoxitin exhibited antibacterial activity against both gramnegative and gram-positive bacteria, and its action was bactericidal. against gram-negative bacteria, cefoxitin was highly active as well as cefazolin, and more active than cefalotin. especially, cefoxi ...1977576821
experimental forms of infection and serological analysis of the antigenic structure of rickettsia canada.experimental forms of rickettsia canada infection were characterized and serological analysis of the antigenic structure of r. canada was carried out. according to its pathogenicity for experimental animals, r. canada can be characterized as a poorly virulent species of rickettsiae, similar to r. prowazekii (for guinea pigs). the complement-fixing, haemagglutinating and agglutinating antigens of r. canada are fairly similar to those of the typhus group rickettsiae. the region of antigenic activi ...1977580434
an epidemic of venereal infection in thoroughbreds.the clinical pattern, bacteriological investigation and subsequent treatment of a serious outbreak of venereal disease in stud farms on both sides of the irish sea is described. the consistency with which bacillus proteus was isolated from infected mares and stallions was remarkable. prompt treatment with ampicillin, to which the organism was sensitive in vitro, eradicated the disease. no local treatment was applied.1977580514
relative efficacy of carbenicillin indanyl sodium and of trimethoprim/sulfamethoxazole in urinary-tract infections.in a 10-day study, carbenicillin indanyl sodium cured urinary-tract infections in 22 of 30 patients (ages, 24-91). in 3 of the remaining patients the treatment was a failure; in 3 others the drug had to be discontinued because of diarrhea and vomiting; and in 2 instances it induced overgrowth of candida albicans in the urine. carbenicillin was lethal to pseudomonas aeruginosa in all 9 cases, to proteus mirabilis in all 6 cases, and to enterococcus in all 3 cases. a trimethoprim/sulfamethoxazole ...1979581878
[bacteriological and clinical evaluation of a dicloxacillin-ampicillin combination (author's transl)].this paper presents the results of the bacteriological and clinical assessment of the dicloxacillin-ampicillin combination totocillin. the bacteriological examinations show that a synergistic and hyperadditive effect particularly on staphylococcus, but also on e. coli, klebsiella-enterobacter and in a few cases on proteus spp. is achieved with the combination. clinical experience in urinary tract infections evidences the good efficacy of the combined preparation, which on statistical evaluation ...1978581996
[dibekacin--a novel aminoglycoside antibioticl. antimicrobial activity and parallel resistance in vitro].dibekacin (orbicin) is a new aminoglycoside antibiotic which chemically differs from tobramycin only by lack of an oh-group. the activity of dibekacin against e. coli, klebsiella, enterobacter, serratia, proteus indol-negative and indol-positive and pseudomonas aeruginosa was compared with that of gentamicin, sisomicin, tobramycin and amikacin by tube dilution procedure. dibekacin showed a high activity against p. aeruginosa including gentamicin-resistant strains. the development of resistance a ...1979582126
serological evidence for the presence of rickettsial infections in parts of nigeria.weil-felix tests using ox19 and oxk proteus antigens reveal high antibody titers to oxk and ox19 antigens in patients reporting at the university of nigeria teaching hospital, enugu with clinical diagnosis of pyrexia of unknown origin. these findings suggest the presence of either or both scrub typhus fever and epidemic typhus fever in this community. while the advisablility of using other diagnostic techniques to support and confirm positive weil-felix reaction will be useful, it is felt that t ...1978582349
comparison of cefazedone with cefazolin and cephalothin in treatment of experimental infections in mice.the chemotherapeutic efficacy of (6r,7r)-7-(2-[3,5-dichloro-4-oxo-1(4h)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio)-8-oxo-5-thia-1-azabicyclo[4,2,0]oct-2-ene-2-carboxylic acid (cefazedone, refosporen) was assayed in comparison to cefazolin and cephalothin in experimental bacterial murine infections with 6 gram-positive and 8 gram-negative strains of the genera staphylococcus, streptococcus, pneumococcus, escherichia, klebsiella, proteus, pasteurella and salmonella. in 5 out of ...1979582716
proteus rettgeri infections: a review.proteus rettgeri is an aerobic gram-negative bacillus that displays marked resistance against most of the antibiotics presently available. this organism causes infections usually confined to the urinary tract of certain types of compromised patients. occasionally, it is recovered from soft tissue abscesses, and rarely from the blood and respiratory tract. proteus rettgeri is notorious for causing nosocomial outbreaks of urinary tract infections in urological and physical medicine wards. our expe ...1977583779
pelviperitonitis and bacteremia due to bacteroides splanchnicus. report of a case.a case of pelviperitonitis and bacteremia due to bacteroides splanchnicus is discussed. it occurred in a 56 year old obese woman who had a history of cholelithiasis and of asymptomatic myomatous uterus. b. splanchnicus was isolated from a blood sample drawn on admission, and from peritoneal pus found at laparotomy on the 11th hospital day. in the latter sample, the strain was associated to proteus mirabilis. the organism was sensitive to all ten antibiotics tested, including penicillin g. aminog ...1977587580
laboratory studies on mecillinam: activity alone and combined with cephradine.mecillinam (mc) was found to be inhibitory at low concentrations to a wide range of gram-negative bacteria; the sensitivity of such strains could be predicted by using a 10 microgram disk. resistance to mc did not appear to be associated with beta-lactamase-mediated destruction of the antibiotic. ampicillin-resistant strains tended to be less sensitive to mc. mc and cephradine acted synergistically against proteus mirabilis, pr. vulgaris, prov. stuartii and serratia marcescens, and the combinati ...1977587708
nosocomial urinary tract infections caused by two o-serotypes of providencia stuartii in one hospital.providencia stuartii nosocomial urinary tract infections occurring in the same hospital over an 18-month period of retrospective study were shown, by serotyping and biotyping, to have been caused by two endemic strains. two episodes, involving 38 patients in one ward and 11 patients in another, were caused by a mannitol-positive strain of serotype o55. transmission of the strain through the movements of one patient appeared to have been the basis for the introduction of the agent from one ward t ...1977591628
the growth and respiration of bacterial colonies.young colonies of two swarming organisms, bacillus subtilis and proteus vulgaris, grew about as quickly on solid media as in liquid culture whilst four non-swarming organisms, bacillus cereus, enterobacter cloacae, escherichia coli and staphylococcus albus, all grew slower on solid than in liquid media. oxygen uptake by young colonies of b. subtilis, followed manometrically, increased exponentially at about the same rate as unrestricted aerobic growth. all other colonies demonstrated acceleratin ...1977591923
[clinical efficacy of s-6436 in urinary tract infection (author's transl)].s-6436 was orally given to the patients mainly with uncomplicated acute cystitis at two divided doses for 7 days with the following results: 1) one or 2g/day of s-6436 were administered to the patients with 93.7% of effectiveness. there is almost no difference in effectiveness between 1 g and 2g dosages. 2) bacteria in urine disappeared in 74% of the patients treated and superinfection occurred in 22%. the disappearance of the bacteria was observed in 83.3% of the patients with e. coli and 60% w ...1977592484
a method for measuring the outer membrane-permeability of beta-lactam antibiotics in gram-negative bacteria. 1977599090
[clinical study of carfecillin in chronic urinary tract infection (author's transl)].1. ten patients with chronic urinary tract infection by pseudomonas aeruginosa or proteus species were treated with carfecillin. excellent response was seen in one case, fairly good in 5 cases and clinical effective rate was 60%. 2. the recurrence suppression effect of carfecillin was examined in two patients suffering from complicated urinary tract infection. in both cases, recurrence was not found when carfecillin was administered for a week after the effective pretreatment of carbenicillin, b ...1977599660
[partial t antigen on red blood cells from a patient with urinary infection due to proteus rettgeri]. 1977601403
[etiologic role of bacteria of the genus providencia in acute intestinal diseases].a study was made of morphological, cultural, biochemical properties and antigenic structure (by o-antigen) of 59 strains isolated in group acute intestinal affection of children at the pioneer camp. by the combination of biochemical properties (31 tests) all the cultures isolated were referred to providencia alcalifaciens of biotype 7. serological typing with the aid of experimental diagnostic agglutinating o-sera showed these strains to be referred to serological group o2. identity of the o-ant ...1977602540
[microheterogeneity of r plasmid coded beta-lactamases in analytical isoelectric focusing (author's transl)].analytical isoelectric focusing of plasmid-coded beta-lactamases in polyacrylamide gels gives rise to several satellite bands in addition to one major active band (microheterogeneity). when the r plasmids are transferred by conjugation into 4 different bacterial species (escherichia coli, klebsiella pneumoniae, salmonella typhi-murium, proteus mirabilis) the position of the main band remains constant, but the number and position of the satellite bands are changed. furthermore, the minimal inhibi ...1977603191
effect of enteric micro-organisms on intestinal sugar and fatty acid absorption.the effect of micro-organisms contaminating the upper intestinal contents of malnourished children on intestinal absorption of 3-0 methyl-alpha-d-glucopyranose (3-m.g.) and oleic acid was studied in rats in vivo. oleci acid absorption was unaffected by non-pathogenic e. coli but decreased by e. coli 0111, salmonella paratyphi b., shigella sonnei and candida sp. this effect was probably explained by intestinal secretion diluting the test solution leading to a decreased diffusion gradient for solu ...1977603464
[specific features of vascular disorders in toxic food infections]. 1977606975
informational molecules in amoebae: an attempt to follow injected fractions using autoradiography.cytoplasmic fractions from amoeba discoides contain informational molecules which, when injected into a. proteus, may influence the characters of resulting clones. an attempt was made to follow and locate these molecules by autoradiography. using either 3h-uridine or 3h-leucine, radioactive fractions of a. discoides were microinjected into a. proteus and cells examined at varying times after injection. a. discoides were injected with the same preparations to serve as controls. grain counts were ...1977608352
nuclear actin: an apparent association with condensed chromatin.in amoeba proteus the concentration of actin is the same in the nucleus and cytoplasm. certain characteristics, e.g., the ready loss of actin from isolated nuclei, suggest that the association with nuclei is normally not a tight one. here we report, however, that when nuclei are isolated several hours after mitotic amebas are placed in actinomycin d (which allows normal progression of mitosis), the nuclei retain substantial amounts of actin. since this finding correlates with other observations ...1977610879
[the etiology of urinary tract infections].the authors have planned a program in order to file and elaborate with a computer the results of urine cultures. from 8.600 specimens, about 86% were negative or doubtful. the data obtained from 1201 positive cultures were processed in order to state the absolute and relative frequency of the bacterial species isolated and their distribution according to their genera, antibiotic resistence, month and sex. among the most representative species the pattern of antibiotic resistence was surveyed. e. ...1977615747
acquired tracheobronchomalacia. a bronchological follow-up study.ninety-four patients with acquired tracheobronchomalacia were followed up between 1967-1977, for an average of 5.2 years. fifty-six were still alive at the end of the period, and 47 of these were reexamined. twenty-one patients had retired on pensions for lung disease. of the 36 patients who underwent rebronchoscopy, tracheomalacia alone was seen in 3 and tracheobrochomalacia in 33. six out of the 9 cases of tracheomalacia and all the 5 cases of bronchomalacia had developed into tracheobronchoma ...1977616225
[5 years of bacteriological analysis. results and observations].the authors examined the bacteriological analysis carried our during a period of five years (june 1971-june 1976), and pointed out the percentage of positivity and sensibility to antibiotics of the bacteria isolated. on a total of 8,263 analysis, 4,327 coprocultures and 2,076 urinocultures have been made, thus occupying the first places in frequency. 195 patogenous enterobacteria have been isolated from coprocultures, corresponding to a positivity of 4.50%. as for the urinocultures positivity re ...1977616266
symptomatic urinary infection in childhood: presentation during a four-year study in general practice and significance and outcome at seven years.thirty-eight children (12 boys and 26 girls) with symptomatic urinary infection have been studied in general practice. patients were collected over a four-year period and we report an incidence of urinary infection according to kass's criterion of 7.7 per 1,000 girls at risk per year and 3.8 per 1,000 boys at risk per year. eighty-four per cent of the children had symptoms which suggested an origin in the genitourinary tract. proteus infection was found in five of the boys and only one of the gi ...1977616858
physical properties of plasmid mor174, which determines bacteriocin production in proteus morganii 174.plasmid mor174 has a molecular weight of 3.6 x 10(6) and a buoyant density of 1.6994 g/cm3. the covalently closed circular form has a sedimentation coefficient of 22s. these are 30 to 40 plasmid copies per genome equivalent, but growth in chloramphenicol results in amplification of the copy number to 600. in proteus morganii 174, mor174 coexists with a cryptic plasmid of molecular weight 15.8 x 10(6) and a buoyant density of 1.7170 g/cm3.1978618846
closure of the plasma membrane around microneedle in amoeba proteus. an ultrastructural study. 1978620690
characteristics of the 'life spanning' phenomenon in amoeba proteus. independent nuclear and cytoplasmic ability to impose finite 'life span'.amoeba proteus given adequate food grows exponentially and clones of amoebae are normally immortal. after periods of food supply restriction to that necessary for maintenance, or food intake restriction by agitation, cells subsequently given a normal growth diet produce clones of finite life span. reciprocal nuclear transfer between maintained and normal cells demonstrated that the nucleus and cytoplasm of maintained cells have acquired the independent ability to impose a finite life span on clo ...1978620943
survey of conjunctival flora in dogs with clinical signs of external eye disease.bacteria were isolated 68% of the time from the conjunctival sacs of 120 dogs with conjunctivitis, blepharitis, dacryocystitis, or corneal ulcerations. coagulase-positive staphylococcus aureus was the most frequently isolated organism (68%); when both eyes were affected, s aureus was recovered from 29% of the dogs; and in dogs with 1 eye affected, s aureus was isolated from 23% of the affected eyes and in 18% of the nonaffected eyes. other organisms recovered from eyes were coagulase-negative st ...1978624664
antimicrobial activity in vitro of cefaclor, a new oral cephalosporin.the antimicrobial activity of cefaclor, a new orally administered cephalosporin derivative, was studied in vitro against a variety of gram-positive and gram-negative clinical isolates. both penicillin-resistant and penicillin-susceptible strains of staphylococcus aureus were susceptible to cefaclor, with mean mics of 1.44 and 0.93 microgram/ml, respectively. however, the mbc for penicillin-resistant s. aureus was higher than that for the penicillin-susceptible strains. all strains of streptococc ...1978624778
consequence of cerulenin-released beta-lactamase in clinical coliforms.periplasmic beta-lactamase of certain clinical coliforms was released, without affecting cell viability, by perturbation of the outer membrane utilizing the fatty acid-mimicking antibiotic cerulenin. release of such compartmentalized beta-lactamase, at high population density, seems to provide an extra margin of resistance to the organisms against cephaloridine.1978626484
pc-904, a new semisynthetic penicillin.sodium 6{d(-)-alpha(4-hydroxyl-1,5 naphthyridine-3-carboxamido)phenylacetamido} penicillanate (pc-904) is a new semisynthetic penicillin with broad-spectrum activity against gram-positive cocci and gram-negative bacilli. at a concentration of 1.56 mug/ml, it inhibited 100% of isolates of proteus mirabilis, 89% of pseudomonas aeruginosa, 67% of escherichia coli, and 45% of enterobacter spp. at a concentration of 12.5 mug/ml, it inhibited 75% of klebsiella spp. and 67% of serratia marcescens. pc-9 ...1978626486
chemotherapeutic evaluation of 5-episisomicin (sch 22591), a new semisynthetic aminoglycoside.5-episisomicin (sch 22591) is a novel semisynthetic aminoglycoside with a spectrum and potency similar to gentamicin in its activity against susceptible bacterial strains, but with increased potency against pseudomonas, providencia, and proteus rettgeri. it is also more active than tobramycin and amikacin against these last-mentioned species.against resistant strains, sch 22591 is significantly more active than gentamicin or tobramycin. against resistant gram-negative bacteria other than pseudom ...1978626490
identification of an antibiotic-producing bacterium from the human intestinal tract and characterization of its antimicrobial product.an antibiotic-producing bacterium repeatedly isolated from human feces was characterized by standard bacteriological methods. the bacterium is a gram-positive bacillus possessing morphological and physiological features similar to those of bacillus subtilis, except that it lacks temperature-resistant spore formation and has peritrichous flagella. the cell-free antibiotic produced by the organism in vitro was effective against some gram-negative and gram-positive bacteria and yeast in minimum inh ...1978626495
biological and chemotherapeutic studies on three semisynthetic cephamycins.three semisynthetic cephamycin antibiotics (7alpha-methoxy-cephalosporins), sk&f 73678, sk&f 83088 (cs-1170) and cefoxitin, have been found to possess favorable biological and chemotherapeutic properties. all three cephamycins are active in vitro against strains of staphylococcus aureus and a variety of gram-negative bacilli. beta-lactamase producing organisms including indole-producing proteus spp., enterobacter spp. and serratia strains as well as certain anaerobic bacteria were found to be su ...1978627526
electron microscopic visualization of transcribed genes in the nucleus of amoeba proteus. 1978631219
hydroxyurea and infected stones.the formation of struvite stones is closely linked to the enzyme urease produced by certain bacteria found in urine. it has been shown that hydroxamic acids will block the activity of this enzyme. one of these, hydroxyurea, in a morning dose of 500 mg. was used in 21 patients for three months or longer. most were then able to acidify their urine despite persistent urinary infection. after three months, treatment with nitrofurantoin (macrodantin and hydroxyurea (hydrea), 78.6 per cent of patients ...1978636134
[flora of the purulent foci of patients at an orthopedic traumatology clinic and its sensitivity to antibiotics].a total of 4664 bacteriological analyses of the wound and purulent discharge from orthopedo-traumatological patients were performed within a 6-year period, i.e. from 1971 to 1976. staphylococci were the dominating microbes of the purulent-inflammatory foci. its part in the monoculture amounted to 64.5--82 per cent. the specific weight of the monocultures of various microbes decreased during the last 3 years, while the number of the microbial associations increased from 11.6 to 25.4 per cent stap ...1978637530
holographic microscopy of glycerination of amoeba proteus.the process of glycerination of amoeba proteus was observed under the holographic microscope with coherent noise elimination. it was found that during glycerination redistribution of cell material occurs, and is accompanied by reversible deformation of the cell cortex. the rôle of the cortex in shape maintenance in glycerinated models was demonstrated.1978641989
[resistance of pyogenic bacteria during a period of five years (author's transl)].the bacteriological results of 4113 clinical specimens (wound-swabs) were analysed. in 40 per cent of positive findings staphylococcus aureus was isolated, furthermore, in decreasing frequency staphylococcus epidermidis, proteus, escherichia coli, pseudomonas aeruginosa, enterococci and haemolysing streptococci. during this study a considerable quota of the examined strains was observed to show large fluctuation in sensitivity, but more than half of the isolates demonstrated increasing resistanc ...1978645263
sisomicin: in vitro activity and pharmacokinetics.in vitro activity of sisomicin and gentamicin was compared in serial dilution tests for 619 bacterial strains (staphylococcus aureus, e. coli, proteus mirabilis, proteus vulgaris, enterobacter, klebsiella, pseudomonas aeruginosa, salmonella, serratia marcescens). mean mic of sisomicin was lower by one geometrical dilution step compared with gentamicin for pseudomonas, proteus vulgaris, klebsiella, and serratia, while it was almost identical with the other species. resistance (mic greater than 5 ...1978649233
clinical experience with cefamandole for treatment of serious bone and joint infections.the safety and efficacy of treatment with cefamandole were evaluated in 30 patients (from 18 institutions) with serious bone and joint infections. five of the subjects were children. the antibiotic was given intramuscularly or intravenously in doses ranging from 2 to 12 g daily for five to 44 days. twenty-six of the 30 patients responded satisfactorily. fourteen of the fifteen infections due to staphylococcus aureus were among the successful cases. other pathogens were streptococci, escherichia ...1978649996
cefamandole in the treatment of infections due to enterobacter and indole-positive proteus.clinical and bacteriologic results are reported for 80 patients treated with 1.5--12 g of cefamandole daily for a variety of infections caused by enterobacter and indole-positive proteus, organisms that have been resistant to most available cephalosporins. of 45 patients with infections due to enterobacter, 41 (91%) had satisfactory clinical responses; 36 were bacteriologic successes, and six cases of complicated urinary tract infections relapsed. of 37 patients with infections due to indole-pos ...1978649997
interference reflection microscopy of adhesion of amoeba proteus.a simple method of observing the adhesive behaviour of large cells by means of interference reflection microscope is described, and some observations of monopodial amoeba proteus are presented. amoebae may contact with the substratum at any point along the long axis of the cells. points of contact are usually few, small and temporary. frequently the cell surface within the contact points oscillates, changing the separation distance from the substratum.1978650677
intestinal bacterial flora of the household lizard, gecko gecko.a total of 114 isolates was recovered from the intestines of 43 househould lizards, gecko gecko. among the important ones were staphylococcus aureus, salmonella typhimurium, pseudomonas aeruginosa, proteus mirabilis and edwardsiella tarda.1978653125
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