mode of action of morganocin 174.morganocin 174-induced lethality was characterized by one-hit kinetics. although it induced simultaneous inhibition of deoxyribonucleic acid, ribonucleic acid, and protein syntheses, the most striking effect of morganocin was a rapid reduction of intracellular adenosine 5'-triphosphate to less than 10% of the initial values within 2 min of addition. accumulation of thymidine, uridine, glutamine, and proline was also inhibited. a gradual efflux of k(+) was observed, but the lethal effects of morg ...1977907330
in vitro activity of cefaclor, a new orally administered cephalosporin antibiotic.the in vitro antibacterial activity of cefaclor, cephalothin, and cephalexin against 261 clinical isolates of staphylococcus aureus and enterobacteriaceae was compared. cefaclor and cephalexin were about equally active against s. aureus. cefaclor was the most active cephalosporin against escherichia coli, proteus mirabilis, and klebsiella pneumoniae. the effect on the antimicrobial activity using a relatively high and low inoculum was pronounced for cefaclor when compared with that of cephalothi ...1977907337
bacteriuria in patients with spinal cord lesions: its relationship to urinary drainage appliances.urine cultures from spinal cord injuried patients demonstrate a high incidence of bacteriuria, with patterns of bacteriuria varying with the mode of drainage. the highest incidence of positive cultures occurs in patients with indwelling or suprapubic catheters, and the lowest in patients who are appliance-free. the organisms occurring most frequently differ from those of the general hospital population as reported by needham, smith and matsen. there is an increase in the incidence of pseudomonas ...1977907447
[therapeutic experience of proteus morganii septicemia with amikacin (author's transl)]. 1977909148
papilledema in endemic typhus.a 21-year-old women developed severe bilateral papilledema during an acute febrile disease. her optic disk margins were blurred and the disks were elevated up to 5 diopters. splinter hemorrhages, cotton-wool exudates, cytoid bodies, and sheathing of veins were also present. the pyrexia was caused by murine typhus diagnosed by serologic tests. these tests revealed that proteus ox-19 agglutination titer rose to 1:12800, and a positive complement fixation test titer was 1:640 with rickettsia mooser ...1977910862
[microbiological pollution of the environment due to breeding. i. enterobacteriaceae due to cattle breeding].enterobacteriaceae from faeces of cattle belonging to four cattle farms situated in the ferrara district were investigated. at the same time, investigation was made of effluent sewage and recipient wells (upstream and downstream). the cattle (of the italian frisona breed) resulted uncontaminated by salmonellae, but proved to be very susceptible to arizona, citrobacter, shigella and s. gallinarum-pullorum infections, coming from the environment. predominant species in faeces were as follows: prot ...1977911464
[the limits of tetracycline treatment in infections of the vagina (author's transl)].the minimal inhibition concentration of tetracycline was tested in 177 strains of gram positive and gram negative species of bacteria from the vagina which were found to be resistant to tetracycline in the agardiffusion test. 170 of the 177 strains (96%) were inhibited with a tetracycline concentration of 512 microgram/ml. six klebsiella-enterobacter strains and one proteus morgaini strain needed a minimal inhibition concentration of 1024 microgram/ml. for a successful local treatment of vaginit ...1977914023
[stable inheritable increase in the level of cell mortality (experiments on amoeba proteus exposed to heat and radiation)].amoeba proteus cultivated as individual lines qt 24 degrees c were exposed to heating at 29 degrees c during three days or to x-rays of 200 kv at a dose of 5 kh or to combination of both. the original method -- periodical resumption of individual lines from sister-cells -- was used to observe the offspring of amoebae during 8 months. it is found that not only radiation but slight heating as well induce unusual hereditary effect in amoebae: stable increase of cell mortality level. the effect was ...1977914032
[nosocomial infections of the urinary tract by proteus rettgeri (author's transl)].out of urine samples from 170 male patients strains of the genus proteus with atypical biochemical characteristics and extensive corresponding multiresistance were isolated. their significance as causative agents in urinary tract infection looks to be established as well as their ability of transfer by cross infection. because of this we are concerned with the epidemiological occurrence of a special biotype of proteus rettgeri as a causative agent in urinary tract infections.1977914313
in vitro and in vivo antibacterial activity of t-1220, a new semisynthetic penicillin.t-1220, sodium 6-[d-(-)-alpha-(4-ethyl-2,3-dioxo-1-piperazinylcarbonyl-amino)- alpha-phenylacetamido] penicillanate, is a new semisynthetic penicillin derivative that possesses a broad spectrum of in vitro antibacterial activity against gram-positive and gram-negative bacteria. t-1220 is more effective than carbenicillin (cb-pc) against pseudomonas aeruginosa, klebsiella pneumoniae, proteus species, and serratia marcescens. addition of human serum to culture media did not significantly alter the ...1977921239
comparison of in vitro antibacterial activity of three oral cephalosporins: cefaclor, cephalexin, and cephradine.cefaclor, a new oral cephalosporin, was compared in vitro with cephalexin and cephradine against 233 organisms. evaluations were performed in mueller-hinton and nutrient broth and agar using two inoculum sizes. in agar, cefaclor had greater antibacterial activity than either cephalexin or cephradine against isolates of escherichia coli, proteus mirabilis, staphylococcus aureus, klebsiella pneumoniae, and salmonella typhi. all three drugs were relatively inactive against isolates of enterococci, ...1977921255
in vitro activities of five oral cephalosporins against aerobic pathogenic bacteria.cefaclor (lilly 99638) and cefatrizine (bl-s640, sk&f 70771) are orally absorbed, broad-spectrum semisynthetic cephalosporins. they were compared in vitro with cephalexin, cephaloglycin, and cepharadine against a variety of aerobic pathogenic bacteria by an agar dilution procedure. cefaclor and cefatrizine were found to be similar or superior to cephalexin, cephaloglycin, and cephradine in terms of activity against gram-positive cocci other than enterococci. only cefatrizine demonstrated any pot ...1977921258
a new pencillin with anti-klebsiella activity: 3-(5-tetrazolyl) penam.the in vitro activity of a new semi-synthetic penicillin, cp-35,587, 3-(5-tetrazolyl) penam, was investigated against 496 clinical isolates of gram-negative bacilli and 113 clinical isolates of gram-positive cocci. all of the gram-positive cocci were sensitive to cp-35,587 except penicillin g resistant isolates of staphylococcus aureus. this antibiotic inhibited a majority of isolates of escherichia coli, klebsiella spp. and proteus mirabilis at a concentration of 6.25 microgram/ml. also, approx ...1977924895
in vitro studies with cefazaflur and other parenteral cephalosporins.cefazaflur has a broad-spectrum of in vitro antibacterial activity equal to or greater than that of the commercially-available cephalosporins. in addition, cefazaflur has activity against isolates of enterobacter, citrobacter and indole-positive proteus; however, this activity decreased markedly when the mic determinations were carried out with a large inoculum size. a similar inoculum effect was observed with cefamandole, however, cefoxitin's activity was relatively unchanged at increased inocu ...1977924896
bacterial infection and acrylic cement in the thirty-one rat tibiae, plugs of plain acrylic cement were inoculated with staphylococcus aureus; these all remained contaminated at the end of two weeks when the animals were killed. inoculation with known strains of pseudomonas, proteus and gp. g streptococcus resulted in 70 to 93 per cent persisting contamination. gentamicin, to which the organisms were fully sensitive, was efficacious in controlling the infection (90 per cent plugs proving sterile after two weeks). fucidin was less success ...1977925056
the dienes phenomenon: identification of the determinants of compatibility.two hundred and four isolates of swarming strains of proteus species which had been typed for their ability to produce bacteriocin (proticine) and also their proticine sensitivity (p/s typing) were tested in all combinations for their dienes compatibility with each other. ninety-eight distinct dienes compatibility groups were found. physiological and genetic experiments supported the evidence of typing results that, irrespective of species, both the type of proticine a strain produces (p type) a ...1977925679
perinephric abscess: a review of 26 cases.herein we review 26 cases of perinephric abscess, analyzed according to incidence, etiology, laboratory findings, signs and symptoms, diagnosis, radiographic findings, operative procedures, mortality and associated diseases. of the abscess cultures 67 per cent were gram-negative organisms, most commonly proteus, and 76 per cent of the abscesses were directly attributable to renal causes, mainly nephrolithiasis. diabetes mellitus occurred in only 3 of the 26 cases.1977926262
[bacterial flora in the course of inoculation cutaneous leishmaniasis in mice]. 1977927364
antimicrobial sensitivity of aerobic gram-negative rods isolated from bovin udder infections.antimicrobial sensitivity of 214 aerobic gram-negative rods recovered from infected bovine mammary glands was determined. seventeen antimicrobial agents were used. more than 90% of the cultures were sensitive to chloramphenicol, gentamicin, and polymyxin b. these 3 antimicrobials are not approved for infusion into the bovine mammary gland. escherichia coli was most sensitive to the 17 antimicrobials, and in decreasing sequence, klebsiella pneumoniae, citrobacter spp, enterobacter spp, and proteu ...1977931132
cefuroxime - a new cephalosporin antibiotic.cefuroxime is a new broad spectrum cephalosporin antibiotic for administration by injection. it is stable to most beta-lactamases. it is active against gram-positive organisms, including penicillinase-producing staphylococci, and has wide activity against gram-negative bacilli including enterobacter and many strains of indole-positive proteus spp. the substance is also highly active against haemophilus influenzae and neisseria gonorrhoeae. studies on human volunteers showed that it produced high ...1976931792
relations between the nuclear activity and the variable 3h-amino acid incorporation pattern in amoeba proteus.tracer kinetic studies have revealed the existence of a variable pattern of 3h-amino acid incorporation into amoeba proteins during the early g2 phase of the cell cycle. two peaks of incorporation of [3h]leucine were found to occur at 19 and 22 h, whereas a single peak at 17 h was noticed in the amoebae labelled with [3h]lysine. an almost 2-fold increase of the labelled amino acid incorporation occurred during the peak periods, while the other periods showed a more or less steady state of incorp ...1976932109
[the bacterial flora of decubitus ulcers and the effects of ultraviolet light on this flora].decubitus ulcers, their treatment, the effect of uv light on bacterial flora of these ulcers, different effects of uv light according to the wave length, the uv lamp used in experiments, and the bacterial flora of wounds in different phases are explained. from 21 patients, with decubitus ulcers under uv treatment, 974 samples were collected before and after uv treatments. these samples were cultured on blood agar plates by the isolation method in 5 steps. after 24 hours incubation, the colonies ...1976933891
laboratory studies with a new broad-spectrum penicillin, pirbenicillin.pirbenicillin {6-[d-2-phenyl-2(n-4-pyridylformimidoylaminoacetamido) -acetamido]-penicillanic acid} showed broad-spectrum antibacterial activity in vitro and also in the treatment of experimental infections after parenteral administration to mice. against pseudomonas aeruginosa, a three- to fourfold potency advantage over carbenicillin was seen both in vitro and in vivo. the in vitro antibacterial spectrum of pirbenicillin includes escherichia coli, serratia, citrobacter, and enterobacter isolat ...1976938027
the incidence and pattern of sepsis among general surgical in-patients at muhimbili hospital, dar es salaam, 1973. 1976939182
a survey of aquarium fishes, their foods, and environmental water for salmonellae.the presence of salmonellae in the pet shop environment, fishes, aquarium water, and in a variety of commercially prepared and natural fish foods was determined. salmonellosis attributed to turtles purchased from pet shops has been responsible for an estimated 280,000 human cases annually in the united states. the possibility that aquarium fishes, or their food and aquatic habitat might also serve as sources of human salmonellosis was deemed worthy of clarification. results of the present survey ...1976940312
[use of the swarming phenomenon for the purpose of isolating pure cultures of salmonellae from feces. i].the authors elaborated and tested a number of elective-differential media for swarming of salmonellae. when pure cultures of proteus, e. coli and salmonellae were seded on these media the latter exeeded the rest of enteric bacteria by the intensity of swarming. in the capacity of saprophyte inhibitors the most effective were media with the addition of penicillin and sodium selenite. satisfactory results were obtained on the mentioned media in isolation of salmonellae from the artificially contam ...1976941609
inhibitory effect of light on growth-supporting properties of eosin methylene blue agar.exposure of eosin methylene blue agar to visible light can alter the ability of that medium to support microbial growth. proteus species were most sensitive to the photodynamic action.1976942204
[studies on the antibacterial activity of the combination sulfamoxole/trimethoprim (cn 3123) (author's transl)].after giving a survey on the situation of antibiotic resistance in the region of northern bavaria during 1973/74 and comparing the activity of a sulfamethoxazole (smz) trimethoprim (tmp) combination to other commonly used antibiotics and chemotherapeutic agents, the results of tests with the new combination of n1-(4,5-dimethyl-2-oxazolyl)-sulfanilamide) (sulfamoxole) and 2,4-diamino-5-(3,4,5-trimethoxy-benzyl)-pyrimidine (trimethoprim) at a ratio of 5:1 (cn 3123; nevin, supristol) are compared t ...1976947327
is the pathogenesis of crohn's disease similar to that juvenile recurrent pyelonephritis? a study of lipid a antibody titers in crohn's disease, ulcerative colitis and acute 18 patients with crohn's disease, 28 patients with ulcerative colitis, 24 patients with enteritis and in 68 healthy adults lipid a antibody titers were determined by the passive hemolysis test. in addition, 0 antibody titers to polyvalent e. coli, klebisella, proteus, and ps. aeruginosa antigens were measured by indirect hemagglutination. the patients with crohn's disease showed a statistically significant elevation of the lipid a antibody titers compared with each of the three other groups i ...1976947846
[combined action of some antibiotics and bile acids on bacteria of the genus proteus]. 1976948274
antibacterial activity of selected beta-lactam and aminoglycoside antibiotics against cephalothin-resistant enterobacteriaceae.the in vitro antibacterial activity of four beta-lactam antibiotics (cefatrizine [bl-s640], cefamandole, cefoxitin, and carbenicillin) and three aminoglycosides (amikacin, gentamicin, and tobramycin) was determined against 197 strains of cephalothin-resistant enterobacteriaceae. eighty strains were found to be gentamicin-sensitive, and 117 were found to be gentamicin-resistant. carbenicillin was the most active beta-lactam antibiotic against gentamicin-sensitive serratia marcescens and enterobac ...1976949175
mecillinam, a novel penicillanic acid derivative with unusual activity against gram-negative bacteria.the in vitro activity of mecillinam, a 6 beta-amidinopenicillanic acid derivative, was investigated. mecillinam is not active against most gram-positive coccal or bacilliary forms. many members of the enterobacteriaceae are inhibited, with 86% of escherichia coli, 71% of klebsiella, 62% of enterobacter, 75% of salmonella, 69% of shigella, and 70% of citrobacter inhibited by 6.3 mug/ml. indole-positive proteus and serratia were generally resistant as are pseudomonas strains. although mecillinam i ...1976949176
activity of cefamandole and other cephalosporins against aerobic and anaerobic bacteria.the activity of cefamandole was comparable to that of cephalothin, cefazolin, and cephaloridine against staphylococcus aureus, streptococcus pyogenes, and diplococcus pneumoniae. in contrast, cefamandole was considerably more active than cephalothin, cefazolin, or cephaloridine against gram-negative facultative bacilli, including haemophilus influenzae, the most striking disparities being noted with indole-positive proteus and enterobacter. bacteroides fragilis was more susceptible to cefoxitin ...1976949182
differential agar medium (a7) for identification of ureaplasma urealyticum (human t mycoplasmas) in primary cultures of clinical material.a differential agar medium for the identification of ureaplasma urealyticum in primary cultures of clinical specimens is described. the differential medium (no. a7) is specific for the identification of u. urealyticum and other members of the genus ureaplasma. large-colony, classical mycoplasma and acholeplasma species and proteus l colonies are unreactive on this differential medium. the medium incorporates the biochemical principle of the direct spot test for urease in colonies of ureaplasma a ...1976950379
[bacterial flora in neurogenic bladder]. 1976951985
providencia stuartii, a hospital pathogen: potential factors for its emergence and transmission.the emergence of providencia stuartii as a hospital pathogen in a burn unit was demonstrated by routine infection surveillance. the organism was initially recognized in a burn wound and subsequently in urine or sputum. compared to controls, those patients harboring p. stuartii were similar in age and percentage of body surface burned and were more likely to have been in one of the two burn unit rooms, (p less than 0.02). infection with p. stuartii was independent of duration in the intensive car ...1976952286
structure and function of the rabbit bladder altered by chronic obstruction or cystitis.decreased muscle contractility has been observed in association with intercellular collagen deposition after acute urinary obstruction. chronically induced (2 months) bladder neck obstruction in rabbits produced similar marked changes in the ultrastructure of the bladder wall, with widening of the intercellular spaces and formation of collagen. resting intravesical pressure was greater in animals with bladder neck obstruction than in the controls, yet response to stimulation was not impaired. ba ...1976955851
nocardicin a, a new monocyclic beta-lactam antibiotic. i. discovery, isolation and characterization.nocardicin a is a new monocyclic beta-lactam antibiotic obtained from the fermentation broth of a strain of actinomycetes. the producing organism, strain ws 1571, was identified as nocardia uniformis subsp. tsuyamanensis atcc 21806. the antibiotic, obtained as colorless crystals, exhibits moderate in vitro antibacterial activity against a broad-spectrum of gram-negative bacteria including proteus and pseudomonas. it has low toxicity in laboratory animals.1976956036
a numerical taxonomic study of proteus-providence bacteria. 1976956066
stool bacterial aerobic overgrowth in the small intestine of children with acute diarrhoea.the aerobic flora of 2 groups of children (normal and with malnutrition) with acute diarrhoea was studied, by intubation of the upper and middle small intestine and by stool culture. all the 27 children studied presented bacterial concentrations of 10(5) germs/ml at one or both levels studied. in 9 cases enteropathogen bacteria e were isolated from stools, and in 6 of these they were also found in the small intestine. the results show the elevated incidence of overgrowth of the small intestinal ...1976961412
nosocomial infection with highly resistant, proteus rettgeri. report of an epidemic.over 22-1/2 months an epidemic of at least 127 cases of nosocomial infection developed from a strain of proteus rettgeri resistant to all antibiotics commonly tested in hospital laboratories. although there were at least four cases of septicemia and one related death, the majority of cases consisted of asymptomatic bacteriuria or clinically mild urinary tract infection. indwelling urinary tract devices and antibiotic therapy were important predisposing factors. data supported an association betw ...1976961694
[effectiveness of antibiotic premedication in colonic surgery].the value of preoperative bowel preparation with antibiotics in colon surgery was studied in a prospective randomized trial: 58 patients received only mechanical and dietary preparation and 50 patients were treated additionally with a combination of neomycin and bacitracin 4 days preoperatively. bacteriologic studies of stools from the day before beginning of preparation and from the day before surgery which were done quantitatively per 1 gram stool revealed that the fecal flora of 90% of the pa ...1976964056
[different types of hereditary changes in cell survival caused by x-rays in different dosage (experiments conducted on amoeba proteus)]. 1976968003
aerobic and anaerobic bacteria in diabetic foot ulcers.twenty diabetic foot ulcers were cultured using optimal microbiologic techniques. anaerobic bacteria coexisted with the more commonly recognized aerobic bacteria in 18 specimens. there were a total of 116 isolates with an average of 5.8 species per specimen (3.2 aerobes and 2.6 anaerobes). the principal isolates were bacteroides species (sp.) (17 strains), peptococci (16), proteus sp. (11), enterococci (9), staphylococcus aureus (7), clostridia (7), and escherichia coli (6). when antimicrobial t ...1976970773
significance of diuresis-provoked bacteriuria.of 52 clinically healthy, ambulant elderly subjects with urine that was sterile or contained less than 0.2 x 10(5) bacteria/ml before diureisi, 11 (21.2%) responded to oral water loading and intravenous treatment with furosemide with a bacterial excretion rate of greater than 2.4 x 10(5)/min. subjects with bacteriuria had decreased blood pressure, rate of creatinine clearance, maximal level of urinary creatinine, and maximal urinary flow. twenty-nine of the nonbacteriuric and eight of the subjec ...1976972265
tobramycin and cephalothin for treatment of suspected sepsis in neutropenic children with cancer.the safety and efficacy of tobramycin and cephalothin in treatment of suspected sepsis were studied in neutropenic children with various malignancies. twenty episodes of suspected sepsis in 19 febrile children with cancer were treated with parenteral tobramycin and cephalothin; the duration of therapy ranged from one to 80 days. in 14 of the 20 episodes of suspected sepsis, a favorable clinical response was achieved within five days after initiation of antibiotic therapy. these episodes included ...1976972278
emergence of gentamicin-resistant bacteria: experience with tobramycin therapy of infections due to gentamicin-resistant organisms.a computerized system for testing and surveillance of bacterial susceptibility to antibiotics was used in monitoring the emergence of gentamicin-resistant strains of aerobic and facultative gram-negative bacilli at massachusetts general hospital since the release of gentamicin for clinical use in 1971. during the period studied, there was a significant increase in the prevalence of gentamicin-resistant bacteria, particularly among pseudomonas, acinetobacter (herellea), and proteus and, more rece ...1976972284
evaluation of tobramycin in severe urinary tract infection.twenty-five patients with severe urinary tract infections were treated with 3 mg of tobramycin/kg per day (given in two doses). susceptible organisms were escherichia coli, proteus, klebsiella, pseudomonas, streptococcus, and enterococcus. clincal conditions in which treatment produced excellent bacteriological results included a wide range of urological disorders; the most common were pyelonephritis, cystitis, and epididymo-orchitis, three patients had septicemia, and 12 had an infection that w ...1976972285
[serological indicators in patients with suppurative processes in the abdominal cavity caused by proteus infection]. 1976972447
quantitative and bacteriological studies of urine specimens from canine and feline urinary tract infections.the most prevalent microorganisms isolated from urine specimens of dogs (385) and cats (132) with clinical signs of urinary tract infections were escherichia coli, proteus spp., and staphylococcus aureus. the results of quantitative urine-culturing methods showed 48.6% of the canine and 12.1% of the feline specimens had more than 10(5) organisms per ml of urine. the bacteria isolated appear to have a greater resistance to antibacterial agents than previously reported.1976977732
[providencia isolated from the stools of patients with gastroenteritis].92 providencia strains were isolated from the stools of patients with gastroenteritis. all specimens were negative for other pathogenes such as salmonella, shigella, enteropathogenic e. coli and vibrios. viral etiology was not investigated. the distribution according to years and months is shown in the table. 17 isolations made during august, seemed rather high and gave the impression of a small epidemic.1976979696
a study of skin diseases in dogs and cats. ii. microflora of the normal skin of dogs and cats.a study of the microflora of the normal skin was undertaken in 10 dogs and 10 cats. swabs were taken from the surface of the skin at 7 different sites (fig. 1). micrococcus spp., alpha-hemolytic streptococci, and acinetobacter spp. were found consistently in both species. staphylococcus aureus was isolated from 9 dogs and 4 cats, and staphylococcus epidermidis from 7 dogs and 5 cats. beta-hemolytic streptococci, corynebacterium spp., bacillus spp., escherichia coli, proteus mirabilis, pseudomona ...1976980697
[a quantitative method of determining lecithinases and lipases in microorganisms].the paper presents a method for quantitative assay of lecithinases and lipases in microorganisms. the method is based on the assessment of changes in the composition of lipid components of yolk media under the influence of corresponding enzymic systems of bacteria. the technique involved lipid extraction from yolk media after cultivation of the microorganisms tested, chromatographic separation by thin-layer chromatography on silicagel into individual fractions, development in iodine vapours and ...1976981203
physical properties and the fine structure of proteocines.proteocines derived from twelve previously described bacteriocinogenic strains of proteus mirabilis and proteus vulgaris were investigated. all proteocine preparations were particulate, unaffected by trypsin, and destroyed by freezing and thawing or by heating at 60 degrees c for 30 minutes. proteocine activity was removed by adsorption with the appropriate sensitive organisms. the active principles of all preparations were partially purified by precipitation with 70% (w/v nh4(so4)2 followed by ...1976983532
wound infection: a prospective study of 7519 operations.wound infection was prospectively studied in 7,519 consecutive operations after preoperative classification as clean, clean-contaminated, and infected. the overall infection rate was 3.9 per cent. clean, 3.2 per cent; clean-contaminated, 4.4 per cent; contaminated, 12.4 per cent; infected, 16.2 per cent. wound infection was not seasonally related or dependent on changes in house staff. in clean cases, the predominant role of staphylococcus aureus (37%) has been superceded by enterococci (44%). i ...1976984592
bioevaluation of the antibacterial flumequine for urinary tract use.the antimicrobial activity of flumequine (r-802) was characterized by in vitro and in vivo procedures. assay of the minimal inhibitory concentrations for 321 recent clinical isolates revealed that 88% of the gram-negative bacteria were inhibited by an r-802 concentration of 6.2 mug/ml or less. cross-resistance in laboratory-derived mutants of proteus vulgaris was essentially complete for r-802, nalidixic acid, and oxolinic acid, although quantitative differences were evident. r-802 was more effe ...1976984753
in vitro activity of gentamicin and minocycline alone and in combination against bacteria associated with intra-abdominal sepsis.the minimal inhibitory concentrations of gentamicin and minocycline alone and in combination were determined by a broth microdilution method for 100 aerobic, facultative, and anaerobic isolates representative of pathogens recovered from patients with intra-abdominal sepsis. gentamicin inhibited all strains of klebsiella, enterobacter, and pseudomonas aeruginosa in concentrations of 0.4 to 3.1 mug/ml and all strains of escherichia coli and proteus mirabilis in concentrations of 0.8 to 12.5 mug/ml ...1976984755
comparative activity in vitro of ticarcillin, bl-p1654, and carbenicillin.the activity of ticarcillin, bl-p1654, and carbenicillin was compared in vitro using a microtiter tube dilution test in mueller-hinton broth against 50 recent clinical isolates each of staphylococcus aureus, staphylococcus epidermidis, escherichia coli, klebsiella species, enterobacter species, proteus species, and pseudomonas aeruginosa. bactericidal end points were determined using a modified steers replicator. ticarcillin was generally two to four times more active against all organisms teste ...1976984764
in vitro evaluation of the new oral cephalosporin cefatrizine: comparison with other cephalosporins.cefatrizine (bl-s640), a semisynthetic, orally administered cephalosporin, was found to have an in vitro spectrum of activity comparable to those of four other cephalosporins tested. it is as effective as cephalexin, the other orally administered cephalosporin evaluated, against most species, and it appears to be more effective than cephalexin against many enterobacter, haemophilus, and proteus strains isolated in our hospital. it is not inactivated by the plasmid-determined beta-lactamases of 1 ...1976984771
comparison of activity of sisomicin and gentamicin in mouse protection tests with gram-negative bacilli.the efficacy of sisomicin and gentamicin was compared in mouse protection studies against strains of escherichia coli, klebsiella sp., enterobacter aerogenes, serratia marcescens, proteus mirabilis, and pseudomonas aeruginosa. there was no significant difference in mortality of the mice in any of the protocol groups when five different dosages of sisomicin and gentamicin given by three separate schedules were compared for each bacterial inoculum in each antibiotic protocol. the mean protective d ...1976984779
comparison of the antibacterial activity of nine cephalosporins against enterobacteriaceae and nonfermentative gram-negative bacilli.the in vitro antibacterial activity of nine cephalosporins (cephalothin, cephaloridine, cephalexin, cefazolin, cefamandole, cefuroxime, cefatrizine, cefoxitin, and cefazaflur) was determined against 344 strains of enterobacteriaceae and 99 nonfermentative gram-negative bacilli. cefamandole, cefazaflur, and cefuroxime were the most active cephalosporins against the enterobacteriaceae (with the exception of serratia marcescens). however, cefoxitin was the only cephalosporin that inhibited all 30 s ...1976984801
bacteria within ovules and seeds.surface-sterilized ovules and seeds of 27 species of plants were cultured in the water of syneresis of a nutrient medium low in agar content. bacteria were obtained from 30% of the ovules, 15% of the seeds of herbaceous plants, 16% of the seeds of woody plants, 5.4% of the overwintered noncereal seeds, and 13.5% of overwintered cereal seeds. in no instance did every ovule or seed of a plant species contain bacteria. no bacteria were obtained from the hard, waxy seeds of mimosa or yellowwood. the ...1976984839
deconjugation of bile acids by human intestinal bacteria.the purpose of this report is to present the deconjugation of bile acids by numbers of strains of bacteria in the small intestine and feces. the small intestinal juice was aseptically aspirated by a double lumen tube with a rubber cover on the tip devised by us ("fukushima type 1"). bile acids were analyzed with thin layer chromatography. the results: 1) among aerobic bacteria, species of which all of the strains split conjugated bile acids was enterococcus, and most of the strains split were st ...1976992250
amikacin in obstetric, gynecologic, and neonatal infections: laboratory and clinical studies.based on the proportion of resistant, moderately sensitive, and sensitive strains, the descending order of activity of amikacin against clinical isolates of urinary pathogens was salmonella, klebsiella, enterobacter, escherichia coli, staphylococcus aureus, citrobacter, proteus species, and pseudomonas aeruginosa. however, amikacin was the most active of the antibiotics tested (including gentamicin and tobramycin) against 100 strains of p. aeruginosa. the calculated half-life of amikacin was sub ...1976993629
ceftezole, a new cephalosporin c derivative i. in vitro and in vivo antimicrobial activity.ceftezole, a new cephalosporin antibiotic similar to cefazolin, has the following chemical structure: (6r,7r)-8-oxo-7[2-(1h-tetrazol-1-yl)acetamido]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-carboxylic acid. ceftezole was found to be a broad-spectrum antibiotic, active in vitro against many species of gram-positive and gram-negative bacteria except pseudomonas aeruginosa, serratia marcescens and proteus vulgaris. the activity of ceftezole against clinical isolates ...1976994325
[enterobacteria of reptiles (author's transl)].the aerobic gram-negative faecal flora of 78 reptiles consisting of 46 species (39 lizards of 23 species, 15 tortoises of 9 species, 24 snakes of 14 species) was studied. salmonella was found to be present in 50% of lizards, in 16% of tortoises and in 16% of snakes. there were all together 15 different serotypes. edwardsiella tarda was isolated in 20% of tortoises, in 12% of snakes but only in 3% of lizards. tortoises represent therefore the possible normal habitat of edwardsiella tarda. we isol ...1976998035
[results of hygienic investigations in hospitals and their consequences (author's transl)].in all parts of the hospitals examined results were found, which demonstrated, in part considerable, gaps in the hygienic systems. therefore the enforcement of the following measures must be emphatically postulated: - development of hospital hygiene plans by competent experts in cooperation with the doctors and nurses in charge. - foundation of commissions for hygiene, who are responsible for preventive measures and for the establishment of a survey of hospital infections. - delegation of the in ...1976998052
correlation of the characters fermentation of trehalose, non-transmissible resistance to tetracycline, and relatively long flagellar wavelength in proteus investigation of strains of proteus morganii isolated from patients in odense, denmark, and of 21 serotype strains revealed a close correlation between the fermentation of trehalose and a non-transmissible resistance to tetracycline. the trehalose fermenting, tetracycline resistant strains had a longer flagellar wavelength than the non-fermenting, sensitive strains. resistance to chloramphenicol occurred only in strains of the former group.1976998259
[antibiotic sensitivity of the causative agents of pyelonephritis in pregnant and puerperal women].the data presented are evident of the fact that the causative agents of pyelonephritis in pregnant women and puerpera are mostly ecsherichia. ilebsiella, enterococcus and ps. aeruginosa were isolated not so often. strains with multiple antibiotic resistance were mainly isolated from the urine. it should be noted that 64 per cent of the klebsiella strains and 90 per cent of the proteus strains were sensitive to ampicillin. it should be taken into account in development of rational therapy of pyel ...1976999246
[sensitivity, to antibiotics and chemical preparations, of proteus cultures isolated from patients with acute intestinal disorders]. 1976999247
[inducible cephalosporinases from proteus morganii].it has been shown that two proteus morganii strains produce an inducible cephalosporinase. no significative difference was shown between them: they present the same isoelectric poit: 8,3 and very similar kinetic constants. the parameter tau, proportional to the half life of antibiotic at low concentration, in presence of beta lactamase, shows that cefamandole is the most stable cephalosporin studied.1976999950
tobramycin, amikacin, sissomicin, and gentamicin resistant gram-negative rods.sensitivities to gentamicin, sissomicin, tobramycin, and amikacin were compared in 196 gentamicin-resistant gram-negative rods and in 212 similar organisms sensitive to gentamicin, mainly isolated from clinical specimens. amikacin was the aminoglycoside most active against gentamicin-resistant organisms, pseudomonas aeruginosa, klebsiella spp, escherichia coli, proteus spp, providencia spp, and citrobacter spp being particularly susceptible. most of the gentamicin-resistant organisms were isolat ...19761000196
proteus vulvitis in childhood. 19761001202
[microflora of jejunal content in patients with dumping syndrome which developed after stomach resection]. 19761007216
[bacteria of the proteus genus in surface waters].the authors present the results of quantitative and qualitative detection of bacteria of the proteus group in the surface waters of various degree of contamination. by the new method of study there was revealed a number of regularities reflecting the ecology of these microbes in water. there proved to be a distinct correlation between the degree of water contamination by salmonellae and proteus at various seasons of the year (the prevalence in spring and autumn and reduction in summer and winter ...19761007714
[identification of conditionally pathogenic enterobacteria in laboratory practice in the diagnosis of acute intestinal diseases].identification of 361 cultures isolated from patients suffering from various acute intestinal diseasesand from persons who had sustained them, as well as from contacts and persons examined prophylactically with the use of various biochemical tests showed that ty their taxonomic properties the cultures were referred to conditionally-pathogenic representatives of enterobacteriaceae of the corresponding genera:citrobacter, hafnia, klebsiella, proteus, providencia. serological typing of the strains ...19761007731
[bacteria of the citrobacter genus as one of the possible indeices of dysbacteriosis in intestinal diseases].a study of the incidence of detection of bacteria of the citrobacter genus in chronic intestinal diseases with the clinical and bacteriological manifestations of dysbacteriosis indicated that the mentioned conditioned pathogenic bacteria were revealed with the same frequency as bacteria of the proteus genus which served as the commonly accepted index of intestinal dysbacteriosis. comparative analysis of the intestinal microbial flora of the patients led to a supposition that bacteria of the citr ...19761007743
cefamandole: in vitro and clinical pharmacokinetics.cefamandole has a broader spectrum and greater potency than the other cephalosporins. it includes haemophilus influenzae, most strains of enterobacter, and many strains of indole-positive proteus and bacteroides, with a lower minimal inhibitory concentration for escherichia coli, klebsiella, etc. concentrations of drug in the serum after the parenteral injection of cefamandole exceed manyfold the minimal inhibitory concentrations of over 82% of the bacteria studied. approximately 65 to 85% is ex ...19761008540
enterotoxin-producing bacteria and parasites in stools of ethiopian children with diarrhoeal disease.enterotoxinogenic bacteria were isolated from 131 (37%) of 354 ethiopian infants and children with acute gastrointestinal symptoms. only one of these isolates belonged to the classical enteropathogenic serotypes of esch. coli. two colonies from each patient were isolated and tested for production of enterotoxin by the rabbit ileal loop test, the rabbit skin test, and an adrenal cell assay. however, only 38% of the isolated enterotoxinogenic strains were esch. coli; the others belonged to klebsie ...19761008593
the surgical significance of the proteus stone.62 patients with staghorn calculi who underwent conservative surgery at the liverpool regional urological centre since 1962 have been reviewed. the evidence shows that stone disease due to proteus is more rapidly progressive than that due to other organisms. recurrences of proteus stones continue to behave in the same manner. complete kidney clearance at operation is an essential part of the management of these stones, if renal substance is to be preserved.19761009318
staghorn calculi of the kidneys. a. clinical review.a series of 91 staghorn calculi are reviewed. possible aetiological factors are analysed. a high incidence of hypercalciuria was found, and the significance of this is discussed. the rates of complete stone clearance after conservative surgery are considered for different types of staghorn calculus and it is felt that local circulatory arrest with kidney cooling may be of value in removing stones due to proteus. the place of elective nephrectomy in the management of staghorn calculi is discussed ...19761009982
transferable gentamicin-tobramycin resistance in nosocomial strains of proteus rettgeri from oncologic patients. 19761015026
[fluid carbenicillin levels after intravenous administration].intravenous infusion of carbenicillin was followed by a determination of the concentration of this antibiotic in both the liquor and serum. the examinations, of which the results are reported in this paper, were made on six patients who had undergone surgical operations to the posterior cranial fossa and on whom lumbar punctures were postoperatively performed every day, as well as on seven hydrocephalic patients where a temporary relief of pressure was obtained by draining excess liquor. the lev ...19761015052
study of genetic relationships among marine species of the genera beneckea and photobacterium by means of in vitro dna/dna hybridization.strains representative of species of the marine genera beneckea and photobacterium were used as reference standards in in vitro dna/dna competition experiments. within a given species, strains were found to be related by over 80% competition. (competition was defined as the amount of radioactive dna displaced by heterologous dna relative to the amount displaced by homologous dna.) on the basis of interspecies competition values (expressed as averages), the following groupings could be made: 1. " ...19761015934
ocular development and involution in the european cave salamander, proteus anguinus laurenti.the anatomy and development of the eye of proteus anguinus are described. the relationships between organogenesis of the eye in embryos and larva and its involution in the young and the adult are discussed. the availability (in breeding cultures) of a significant number of proteus embryos (which are normally rare) allowed experimental analysis of the effects of light, xenoplastic differentiation and thyroid hormones on the development of the eye. the results of this study suggest that developmen ...19761016662
recurrence of infected calculi following postoperative renal irrigation with stone solvent.renacidin has been shown to dissolve small fragments of infected renal calculi in vitro. 34 patients with infected calculi have undergone pyelolithotomy and postoperative renal irrigation with renacidin. 30 patients were women and proteus was the commonest infecting organism. renal irrigation appears to be safe if closely monitored and covered by antibiotic therapy. 24.4% of calculi had recurred at a mean follow-up of 42 months. the rate of recurrence or unilateral calculi was much less than tha ...19761016826
concentrations of cefazolin in human skeletal muscle.tissue concentrations of cefazolin were measured in 18 patients undergoing urological operations. specimens of skeletal muscle and blood were taken simultaneously at predetermined intervals. the concentrations in serum and homogenized skeletal muscle were determined by means of the agar well diffusion method. a comparison of standard curves obtained with phosphate buffer solution and the supernatant of muscle homogenate revealed no substantial binding of cefazolin to the supernatant of muscle ho ...19761017877
timing of nucleolar dna replication in amoeba proteus.light- and electron-microscope autoradiography have been used to follow the incorporation of [3h]thymidine at different stages during the interphase of synchronously growing populations of amoeba proteus. two main patterns were found for tritiated thymidine incorporation, i.e. dna synthesis. the major incorporation was in the central region of the nucleus, but a lesser degree of incorporation occurred in the nucleolar region. the bulk of this nucleolar dna was found to be late replicating, i.e. ...19761018044
[c-reactive protein in inflammatory processes of the female genital organs].c-reactive protein (crp) was investigated in 202 women: in 20 women with acute non-specific inflammation and the presence of different bacteria (streptococcus pyocyaneus, enterococcus, escherichia colli, proteus), in 12 women with confirmed genital tuberculosis, in 66 women with the chronic inflammation of genital organs, and in 104 women with normal genital findings. in all patients with acute inflammations crp was positive. it was highly positive in those with elevated temperature and sediment ...19761018499
changes in the bacterial cecal flora of mice infected with trichuris muris (schrank, 1788).cecal microorganisms of mice were categorized and enumerated weekly during the developmental cycle of infection with the whipworm, trichuris muris. the cecal bacterial population consisted of escherichia coli, proteus spp, acinetobacter lwoffi (mima polymorpha), aerobic lactobacilli, staphylococci, enterococci, and anaerobes (bacteroides, streptococci, and lactobacilli) in control and t. muris-infected mice. the aerobic lactobacilli and the anaerobes constituted the greatest number of organisms ...19761019388
[indices of bacterial contamination and natural resistance in wistar line laboratory rats].conventional laboratory rats of wistar line are contaminated with bacterial flora. the predominating bacteria in the intestine were the rod-like forms, while in the mouth cavity and vagina predominated the coccal forms. the contamination level of the cavities and penetration of the contaminants into the internal organs depended on the state of the host natural resistance.19761020946
[vocal and laryngo-tracheal sequelae of prolonged intubation at the university medical clinic of the cantonal hospital at lausanne].70 patients (39 men and 31 women) submitted to a prolonged intubation at the centre respiratoire de la clinique médicale universitaire de lausanne have been investigated. they represent the half of the patients having survived of 488 cases treated between january 1966 and june 1974. 33% of the investigated patients (i.e. 18% of all men and 48% of all females) complain about a permanent dysphonia related to the intubation. 17% of the patients (i.e. 13% of all men and 23% of all females) presented ...19761034272
proteus morganii meningitis treated with trimethoprim-sulfamethoxazole (co-trimoxazole). 19751040551
antibacterial activity of combinations of cefazolin and semisynthetic penicillins.the antibacterial activity of cephalosporin (cs) and semisynthetic penicillins was studied using cs-resistant strains of escherichia freundii and proteus morganii. a synergistic growth inhibitory action toward these microorganisms was demonstrated by a qualitative method and confirmed by a quantitative determination.19751041717
cefamandole: antimicrobial activity in vitro of a new cephalosporin.cefamandole, a new cephalosporin derivative, was found to have a broad spectrum of activity against a cross-section of both gram-positive and gram-negative bacteria isolated from clinical material. gram-positive cocci, except for streptococcus faecalis, were very susceptible. penicillin g-resistant staphylococcus aureus also was susceptible to cefamandole. minimal bactericidal concentrations for gram-positive cocci approximated the minimal inhibitory concentrations. strains of haemophilus influe ...19751044248
pc-904, a novel broad-spectrum semisynthetic penicillin with marked antipseudomonal activity: microbiological evaluation.pc-904, sodium 6-{d(-)-alpha-(4-hydroxy-1,5-naphthyridine-3-carboxamido) phenylacetamido}-penicillanate, is a novel semisynthetic penicillin derivative that possesses a broad spectrum of in vitro and in vivo antibacterial activities. in low concentrations, pc-904 inhibits growth against large proportions of the gram-positive and gram-negative organisms susceptible to carbenicillin and gentamicin. in addition, pc-904 is several times more potent than carbenicillin against organisms such as pseudo ...19761046355
multidrug-resistant proteus rettgeri: an emerging problem.the recent development of multidrug-resistant strains of proteus rettgeri prompted a 6-year review of infections with this organism. ninety percent of infections involved the urinary tract. fifty percent of infections occurred on the neurology ward, where a progressive annual increase in attack rate was noted. statistically significant (p less than 0.005) increases in total length of hospitalization, length of hospitalization before infection, presence and duration of indwelling foley catheteriz ...19761047989
[verdoglobinuria: the green urine syndrome]. 19751052374
identification of the cultivable bacteria in dental plaque from the beagle dog.fifteen different genera of microorganisms were isolated from the 27-month-old plaque of two beagle dogs. they were as follows: pseudomonas, proteus, neisseria, escherichia, staphylococcus, streptococcus, lactobacillus, nocardia, actinomyces, corynebacterium, micrococcus, microbacterium, brevibacterium, arthrobacter, and kurthia. the dog plaque was characterized by a low number of streptococci and the presence of several noncarbohydrate-fermenting organisms.19761069758
[the inhibitory effect of some antibiotics upon histamine production and growth of proteus morganii. gentamycin, tetracycline, penicillin, streptomycin and combination of penicillin with streptomycin (author's transl)]. 19751074032
Displaying items 1501 - 1600 of 15180