Publications

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microbial persistence: a clinical reminder. 200515913172
using ontologies in proteus for modeling proteomics data mining applications.bioinformatics applications are often characterized by a combination of (pre) processing of raw data representing biological elements, (e.g. sequence alignment, structure prediction), and an high level data mining analysis. developing such applications needs knowledge of both data mining and bioinformatics domains, that can be effectively achieved by combining ontology about the application domain and ontology about the approaches and processes to solve the given problem. in this paper we talk a ...200515923712
modeling and designing a proteomics application on proteus.biomedical applications, such as analysis and management of mass spectrometry proteomics experiments, involve heterogeneous platforms and knowledge, massive data sets, and complex algorithms. main requirements of such applications are semantic modeling of the experiments and data analysis, as well as high performance computational platforms. in this paper we propose a software platform allowing to model and execute biomedical applications on the grid.200515924180
characterization of a cdna of peroxiredoxin ii responding to hydrogen peroxide and phagocytosis in amoeba proteus.phagocytic cells have defense systems against reactive oxygen species generated as the first non-specific defense mechanism against invading pathogens or microorganisms. we cloned a cdna encoding a 21.69-kda protein in amoeba proteus homologous to 2-cys peroxiredoxin (prx-ap). in the disk inhibition assay using h2o2 as an oxidizing agent, escherichia coli overproducing prx-ap showed better viability than did e. coli transformed with pbluescript ii sk for control. monoclonal antibodies (mab) prod ...200515926998
sternal split approach to the cervicothoracic junction in children.we present a descriptive case series outlining the surgical technique and outcome in six patients managed with a combined anterior neck and sternal splitting approach.200515928540
preventive and therapeutic administration of an indigenous lactobacillus sp. strain against proteus mirabilis ascending urinary tract infection in a mouse model.probiotics are increasingly being considered as non-pharmaceutical and safe potential alternatives for the treatment and prevention of a variety of pathologies including urinary tract infections. these are the most common infections in medical practice and are frequently treated with antibiotics, which have generated an intense selective pressure over bacterial populations. proteus mirabilis is a common cause of urinary tract infections in catheterised patients and people with abnormalities of t ...200515928974
organisms causing urinary tract infection in pediatric patients at ayub teaching hospital abbottabad.urinary tract infection (uti) is common in pediatric practice and an important cause of morbidity and mortality in children. infected urine stimulates an immunological and inflammatory response leading to renal injury and scarring, ultimately leading to end stage renal failure. the present study identifies the micro organisms causing urinary tract infection in children presenting with uti at ayub teaching hospital, abbottabad.200515929535
plasmid-mediated, inducible ampc beta-lactamase (dha-1)-producing enterobacteriaceae at a korean hospital: wide dissemination in klebsiella pneumoniae and klebsiella oxytoca and emergence in proteus mirabilis.the aim of the study was to investigate the phenotypic and genetic characteristics of recently emerging cefoxitin-resistant and induction-positive isolates of escherichia coli, klebsiella species, and proteus mirabilis. strains of enterobacteriaceae were isolated at a korean tertiary care hospital between june and december 2002. induction was tested using cefoxitin and aztreonam disks, the bladha allele was detected by pcr, and pulsed-field gel electrophoresis (pfge) patterns were also analyzed. ...200515936167
antibiotic resistance of urinary pathogens in female general practice patients.a cross-sectional study was performed to determine the prevalence of antibiotic resistance in women with uncomplicated and complicated lower urinary tract infection (uti) in germany. in 36 (of 118 invited) general practices, urine cultures and resistance testing were performed during 4 months on all women presenting with symptoms of uti. each patient's symptoms, risk factors and treatment were documented. a total of 445 women were included, and their median age was 53 y. complicating factors wer ...200515871164
detection of anti-dsdna by elisa using different sources of antigens.to compare different sources of dna for use in elisa-based assays for anti-dsdna antibody detection in systemic lupus erythematosus (sle) diagnosis.200515875736
antibacterial potential from indian suregada angustifolia.phytochemical analysis of the leaves from indian suregada angustifolia (baill. ex muell. arg.) airy shaw (euphorbiaceae) resulted in the isolation and identification of six known compounds, viz. friedelin, epi-friedelinol, n-octacosanol, alpha-amyrin, beta-sitosterol and beta-sitosterol-3-beta-d-glucopyranoside. aqueous (room temperature, boiled and autoclaved) and various solvent (methanol, chloroform and hexane) extracts of leaves were tested against 12 human pathogenic bacteria by the agar we ...200515878247
early extreme contradictory estimates may appear in published research: the proteus phenomenon in molecular genetics research and randomized trials.divergent results on the same scientific question generate controversy. we hypothesized that controversial data are attractive to investigators and editors, and thus the most extreme, opposite results would appear very early rather than late, as data accumulate, provided data can be generated rapidly.200515878467
antagonistic activity of a natural fungal population towards pathogenic bacteria. an in vitro study.in the present work, we performed in vitro testing of 33 species of fungi of the subdivision deuteromycotina isolated from water and sediment of the kolubara river for antagonistic action towards 11 species of pathogenic bacteria. of gram-negative bacteria, the species most sensitive to metabolic fluid of the fungi were proteus mirabilis, salmonella enteritidis, and shigella sonnei, while the most resistant were klebsiella pneumoniae and salmonella typhimurium. of gram-positive bacteria, the mos ...200515889346
synthesis of schiff bases of 2-amino-5-aryl-1,3,4-oxadiazoles and their evaluation for antimicrobial activities.twenty schiff bases of 2-amino-5-aryl-1,3,4-oxadiazoles have been synthesized with different aromatic aldehydes. the structures of the compounds were confirmed by nitrogen analysis, ir and 13c-nmr spectral data. the antibacterial properties of the compounds were investigated against proteus mirabilis (mtcc-425), pseudomonas aeruginosa (mtcc-424), bacillus subtilis (mtcc-619) and staphylococcus aureus (mtcc-96) using the broth dilution method. the most active compounds were 4c (64 microg/ml), 4f ...200515942874
characterisation of the rac/pak pathway in amoeba proteus.molecular mechanisms underlying the unique locomotion of the highly motile amoeba proteus still remain poorly understood. recently, we have shown that blocking the endogenous amoebal rac-like protein(s) leads to distinct and irreversible changes in the appearance of these large migrating cells as well as to a significant inhibition of their locomotion. to elucidate the mechanism of the rac pathway in amoeba proteus, we tested the effects of blocking the endogenous myosin i heavy chain kinase (mi ...200515948264
sesquin, a potent defensin-like antimicrobial peptide from ground beans with inhibitory activities toward tumor cells and hiv-1 reverse transcriptase.an antifungal peptide with a molecular mass around 7 kda and an n-terminal sequence highly homologous to defensin was isolated from ground beans (vigna sesquipedalis cv. 'ground bean'). the peptide was adsorbed on affi-gel blue gel and on mono s. it exerted an antifungal action on botrytis cinerea, fusarium oxysporum and mycosphaerella arachidicola; and an antibacterial action on escherichia coli b, proteus vulgaris, mycobacterium phlei and bacillus megaterium. the antimicrobial activity was inh ...200515949629
adaptation to extreme environments: macromolecular dynamics in complex systems.what we previously thought of as insurmountable physical and chemical barriers to life, we now see as yet another niche harbouring 'extremophiles'. extremophiles and their macromolecules had to develop molecular mechanisms of adaptation to extreme physico-chemical conditions. using neutron spectroscopy, we have demonstrated that molecular dynamics represents one of these molecular mechanisms of adaptation. to which extent do hyper-saline conditions and extreme temperatures influence molecular dy ...200515951115
dentomaxillofacial imaging in proteus syndrome.proteus syndrome is a rare condition that involves atypical growth of the bones, skin and head and a variety of other symptoms. only a few authors have reported on the craniofacial manifestations so far. the authors present a case of a 7-year-old girl with proteus syndrome in which the facial skeleton showed unilateral overgrowth. the analysis of the radiological evaluation revealed a bialveolar prognathism, a skeletal class iii, a dolicocephalic growth pattern and a left convex face scoliosis. ...200515961602
spread of novel expanded-spectrum beta-lactamases in enterobacteriaceae in a university hospital in the paris area, france.in 2002, 28 non-duplicate enterobacterial isolates producing extended-spectrum beta-lactamases (esbls) were collected from infected patients at the bicêtre hospital in paris, france. escherichia coli was the predominant esbl-positive enterobacterial species, comprising ten (36%) of the isolates. ctx-m enzymes (ctx-m-3, ctx-m-10, ctx-m-14 and ctx-m-15) were produced by 11 (39%) of the isolates (six e. coli, two enterobacter cloacae, one enterobacter aerogenes, one proteus mirabilis and one citrob ...200515966981
first description of dha-1 ampcbeta-lactamase in proteus mirabilis.this report describes the first occurrence of the dha-1 ampcbeta-lactamase gene in proteus mirabilis. the organism was isolated from the vaginal flora of a pregnant woman in a french hospital. the dha-1 beta-lactamase gene was identified on the basis of phenotypic characteristics, pcr amplification and sequencing. antagonism between cefoxitin and the other cephalosporins suggested inducible production of the dha-1 enzyme.200515966982
in-vitro antibacterial, antifungal and cytotoxic properties of sulfonamide--derived schiff's bases and their metal complexes.a series of new antibacterial and antifungal schiff's bases derived from sulfonamides, as well as their transition metal complexes incorporating cobalt (ii), copper (ii), nickel (ii) and zinc (ii) were synthesized, characterized and screened for their in-vitro antibacterial activity against six gram-negative (escherichia coli, klebsiella pneumoniae, proteus mirabilis, pseudomonas aeruginosa, salmonella typhi and shigella dysentriae) and four gram-positive (bacillus cereus, corynebacterium diphth ...200515968823
[antibiotic resistance transformation in community-acquired urinary infections].to detect the prevalence of uropathogens in community-acquired urinary tract infection in our environment, and the degree of sensitivity to antibiotics used as empirical treatment.200515970133
noninvasive biophotonic imaging for monitoring of catheter-associated urinary tract infections and therapy in mice.urinary tract infections (utis) are among the most common bacterial infections acquired by humans, particularly in catheterized patients. a major problem with catheterization is the formation of bacterial biofilms on catheter material and the risk of developing persistent utis that are difficult to monitor and eradicate. to better understand the course of utis and allow more accurate studies of in vivo antibiotic efficacy, we developed a catheter-based biofilm infection model with mice, using bi ...200515972473
antimicrobial susceptibility pattern of blood isolates from a teaching hospital in north india.bloodstream infections are associated with significant patient morbidity and mortality worldwide. in this study, we examined antimicrobial susceptibility patterns by reviewing the data on 5,704 blood samples that were collected from patients with fever/sepsis admitted to government medical college and hospital, chandigarh, india, over a period of 1 year from august 2003 to july 2004. among the 567 qualifying samples, pseudomonas aeruginosa (19.75%), escherichia coli (15.17%), klebsiella pneumoni ...200515973011
bioactivity guided isolation of antimicrobial compounds from lythrum salicaria.lythrum salicaria extracts showed activity against the phytopathogenic fungus cladosporium cucumerinum and activity against the bacteria staphylococcus aureus, proteus mirabilis and microccocus luteus. bioautography on thin-layer chromatograms was used to isolate the two antifungal triterpenoids oleanolic and ursolic acid. the hexahydroxydiphenoyl ester vescalagin was isolated as active principle of the antibacterial activity. furthermore, the flavon-c-glucosides vitexin, isovitexin, orientin an ...200515975734
structure of the o-polysaccharide of proteus mirabilis oc (ccug 10702) from a new proposed proteus serogroup o75.a neutral o-polysaccharide was obtained by mild acid degradation of the lipopolysaccharide of proteus mirabilis oc (ccug 10702) and studied by sugar and methylation analyses and (1)h and (13)c nmr spectroscopy. the following structure of the tetrasaccharide repeating unit of the polysaccharide was established: [structure: see text]. based on the unique structure of the o-polysaccharide and serological data, we propose classifying p. mirabilis oc (ccug 10702) into a new separate proteus serogroup ...200515979596
proteus mirabilis bloodstream infections: risk factors and treatment outcome related to the expression of extended-spectrum beta-lactamases.bloodstream infection (bsi) due to proteus mirabilis strains is a relatively uncommon clinical entity, and its significance has received little attention. this study was initiated to evaluate risk factors and treatment outcome of bsi episodes due to p. mirabilis producing extended-spectrum beta-lactamases (esbls). twenty-five bsi episodes caused by p. mirabilis occurred at our hospital (ospedale di circolo e fondazione macchi, varese, italy) over a 7.5-year period. phenotypic and molecular metho ...200515980325
peptides selected for binding to a virulent strain of haemophilus influenzae by phage display are bactericidal.nontypeable haemophilus influenzae (nthi) is an obligate parasite of the oropharynx of humans, in whom it commonly causes mucosal infections such as otitis media, sinusitis, and bronchitis. we used a subtractive phage display approach to affinity select for peptides binding to the cell surface of a novel invasive nthi strain r2866 (also called int1). over half of the selected phage peptides tested were bactericidal toward r2866 in a dose-dependent manner. five of the clones encoded the same pept ...200515980377
proteus: identifying signatures in protein termini.proteus (protein terminus) is a web-based tool for the identification of short linear signatures in protein termini. it is based on a position-based search method for revealing short signatures in termini of all proteins. the initial step in proteus development was to collect all signature groups (sigs) based on their relative positions at the termini. the initial set of sigs went through a sequential process of inspection and removal of sigs, which did not meet the attributed statistical thresh ...200515980469
clinical management and outcome of childhood lung abscess: a 16-year experience.in order to evaluate the clinical manifestations, management and outcome of childhood lung abscess, a retrospective chart review of 27 pediatric patients with international classification of diseases, ninth revision-clinical modification (icd-9 cm) code of 503.1 (lung abscess) from august 1987 to august 2003 was conducted. among the 27 patients (14 males and 13 females), 30% (8/27) were primary lung abscess and 70% (19/27) had underlying chronic diseases (secondary lung abscess). the predisposin ...200515986068
selective iga immune unresponsiveness to proteus mirabilis fumarate reductase a-chain in rheumatoid arthritis.to determine if selective immune unresponsiveness to microbial antigens is associated with predisposition to rheumatoid arthritis (ra).200515996053
aetiology of catheter-associated bacteriuria in lagos university teaching hospital.a prospective study to determine the causative agents of catheter-related bacteriuria was carried out on 99 patients with median age of 55 years, on admission in the oncology, paediatric surgery and obstetric and gynaecology wards of the lagos university teaching hospital. there was significant bacteriuria in seventy-one (72%) of the 99 urine samples. all catheter urine samples were contaminated by day 5 gram-negative bacilli were predominant (89.3%) of which pseudomonas aeruginosa (26.2%) was t ...200515997255
[long-term efficacy of trus-guided transperineal needle aspiration and irrigation on persistent hematospermia].to evaluate the long-term efficacy of transrectal ultrasonography (trus)-guided transperineal needle aspiration and irrigation for persistent hematospermia.200515999493
ampc disk test for detection of plasmid-mediated ampc beta-lactamases in enterobacteriaceae lacking chromosomal ampc beta-lactamases.although plasmid-mediated ampc beta-lactamases were first reported in the late 1980s, many infectious disease personnel remain unaware of their clinical importance. these enzymes are typically produced by isolates of escherichia coli, klebsiella spp., proteus mirabilis, and salmonella spp. and are associated with multiple antibiotic resistance that leaves few therapeutic options. plasmid-mediated ampc beta-lactamases have been associated with false in vitro susceptibility to cephalosporins. many ...200516000421
[xanthogranulomatous pyelonephritis: presentation of an unusual case].xanthogranulomatous pyelonephritis is a morphologically and clinically unique manifestation of chronic pyelonephritis with the formation of pus or granulomas. the most frequent predisposing factors for the development of xanthogranulomatous pyelonephritis are urinary obstruction (e. g., stones, tumors, congenital anomalies and functional impairment) and infection of the collecting system.200516001341
evaluation of cd4(+)/cd8(+) status and urinary tract infections associated with urinary schistosomiasis among some rural nigerians.data on urinary schistosomiasis in nigeria are mainly epidemological. the knowledge of co-infections of urinary schistosomiasis and other pathogens are important epidemiological tools for the control and health benefits of the rural dwellers. the granulomatous reactions in urinary schistosomiasis is cd4(+) dependent. the cd8(+) is cytotoxic to parasites and it is activated by cd4(+). these parameters therefore participate in the immune responses to urinary schistosomiasis.200516006219
analysis of pten gene mutations in korean patients with cowden syndrome and polyposis syndrome.pten (phosphatase and tensin homologue deleted in chromosome 10) is a candidate tumor suppressor gene. mutations of this gene are responsible for pten hamartoma tumor syndromes, including cowden syndrome, bannayan-riley-ruvalcaba syndrome, proteus syndrome, and proteus -like syndromes. recently, pten mutations were identified in several human neoplasms. we analyzed the dna of various organs and lesions in korean patients with cowden syndrome, their family members, and patients with familial aden ...200516007494
etiological and clinical patterns of childhood urolithiasis in iraq.this study was conducted to evaluate the etiological and clinical characteristics of urolithiasis in iraqi children. from 1999 to 2004, 204 children with renal calculi were evaluated. the age range of the patients was 4 months to 14 years, 61.3% of the patients were under 5 years. male to female ratio was 2.8:1. the mean age at onset of symptoms was 3.2 years, and stone disease was diagnosed at a mean of 3.5 years. hematuria (44.6%) and pain (28.4%) were the main clinical presentation. of the 20 ...200516010596
proteus syndrome: an update.proteus syndrome is a complex disorder consisting variably of disproportionate, asymmetric overgrowth of body parts; cerebriform connective tissue nevi; epidermal nevi; vascular malformations of the capillary, venous, and lymphatic types; and dysregulated adipose tissue. serious complications may ensue, such as pulmonary embolism, cystic lung disease, and various neoplasms. somatic mosaicism, lethal in the nonmosaic state, is the best working hypothesis. although proteus syndrome data are consis ...200516010681
[synthesis and antibacterial activity of 3-(5-substituted phenyl-[1,3,4] oxadiazole-2-yl-methylenethio)-5-pyridin-3-yl-[1,2,4] triazole-4-yl-amines].to study on synthesis and antibacterial activity evaluation of polyheterocycles.200516011262
swarmer cell differentiation in proteus mirabilis.under the appropriate environmental conditions, the gram-negative bacterium proteus mirabilis undergoes a remarkable differentiation to form a distinct cell type called a swarmer cell. the swarmer cell is characterized by a 20- to 40-fold increase in both cell length and the number of flagella per cell. environmental conditions required for swarmer cell differentiation include: surface contact, inhibition of flagellar rotation, a sufficient cell density and cell-to-cell signalling. the different ...200516011745
molecular characterization of multidrug-resistant proteus mirabilis isolates from retail meat products.sixty-four multidrug-resistant isolates of proteus mirabilis were collected from retail meat products in oklahoma. the isolates showed four different patterns of antibiotic resistance based on their resistant phenotype and genotypes. most of these isolates were resistant to ampicillin, tetracycline, gentamycin, and kanamycin. class 1 integrons were detected as a common carrier of the antibiotic-resistant genes, such as aada1, aadb, and aada2. a few isolates (9%) contained class 2 integrons with ...200516013378
colouterine fistula mimicking pyometrium--diagnosis established with multi-detector computed tomography. 200516022134
pyrrolobenzodiazepine dimers: novel sequence-selective, dna-interactive, cross-linking agents with activity against gram-positive bacteria.pyrrolo[2,1-c][1,4]benzodiazepine (pbd) dimers are synthetic sequence-selective interstrand dna minor-groove cross-linking agents developed from anthramycins. we investigated the antibacterial activity of three dimers, sjg-136, drg-16 and elb-21, which differ in the structure of the pbd monomeric unit and the length of the linker region between the two identical pbd monomers.200516024592
[species-specific detection of proteus vulgaris and proteus mirabilis by the polymerase chain reaction].sets of primers for the species-specific detection of p. mirabilis and p. vulgaris by the polymerase chain reaction (pcr) were developed. as targets for these primers beta-lactamase and 16s rrna gene fragments were chosen on the basis of the multiple leveling of the sequences of the dna of all known p. mirabilis and p. vulgaris isolates. for differential detection oligonucleotides were selected in such a way that primers, specific for p. vulgaris, contained the non-paired nucleotide for p. mirab ...200516028510
preclinical evaluation of rapeseed, raspberry, and pine bark phenolics for health related effects.rapeseed, raspberry, and pine bark are promising bioactive sources of plant phenolics selected from among ca. 100 previously screened plant materials for in vitro preclinical evaluation of health related effects. phenolic extracts and isolated fractions of the selected materials were investigated for antioxidant, antimicrobial, antiinflammatory, and antimutagenic properties as well as for cell permeability. it was shown that rapeseed and pine bark phenolics and raspberry anthocyanins were good o ...200516028975
extended-spectrum beta-lactamases.the first beta-lactamase was identified in an isolate of escherichia coli in 1940. to date, there are >130 tem-type and >50 sulfhydryl variable (shv)-type beta-lactamases, mainly in e. coli, klebsiella pneumoniae, and proteus mirabilis but also in other members of the enterobacteriaceae family and in some nonenteric organisms, such as acinetobacter species. the incidence of expanded-spectrum beta-lactamases (esbls) varies, depending on which area of the globe the isolates originate from. esbls r ...200516032564
recalcitrant scoliosis in proteus syndrome.proteus syndrome is a rare congenital condition with various clinical features such as hemihypertrophy, macrodactyly, subcutaneous masses, brain-like hyperplasia of the soles and/or palms, epidermal naevi and scoliosis with other mesodermal malformations. multifocal overgrowth can affect various tissues causing severe functional and cosmetic disability, but intellectual and language development are mostly normal. orthopaedic problems include macrodactyly, hindfoot deformity, limb length inequali ...200516035717
antimicrobial susceptibility patterns of contemporary pathogens from uncomplicated urinary tract infections isolated in a multicenter italian survey: possible impact on guidelines.during 2004 four italian laboratories assessed the prevalence of antimicrobial resistance among uropathogens causing acute uncomplicated cystitis in female out-patients. a total of 600 urine samples from individuals aged 18-65 were studied. the overall prevalence of escherichia coli was 85.3%. klebsiella pneumoniae, staphylococcus saprophyticus, proteus mirabilis, enterococcus faecalis and other rarer species were far less represented. determination of the antibiotic susceptibility pattern of th ...200516038517
antibacterial and antioxidant activities of ethanol extract from paullinia cupana mart.the antibacterial and antioxidant activity of the ethanol extract from paullinia cupana var. sorbilis mart. (sapindaceae) seeds, commonly called guarana, was assessed towards selected bacteria as well as in different antioxidant models. the extract, at a concentration between 16 and 128 microg/ml, showed a significant antibacterial effect expressed as minimum inhibitory concentration (mic) against both gram-negative and gram-positive bacteria. in particular, pseudomonas aeruginosa (mic=16 microg ...200516040216
tigecycline.new antimicrobial agents are urgently needed for clinical use due to the increasing prevalence and spread of multidrug-resistant bacteria that are commonly responsible for serious and life-threatening diseases. the need to develop new agents that effectively overcome existing mechanisms of resistance displayed by bacteria resistant to currently available drugs has become paramount. tigecycline, the first in a new class of antimicrobials, the glycylcyclines, is an analogue of minocycline with add ...200516040625
application of electrospray ionization with fourier transform ion cyclotron resonance mass spectrometry for structural screening of core oligosaccharides from lipopolysaccharides of the bacteria proteus.electrospray ionization with fourier transform ion cyclotron resonance mass spectrometry (esi-fticrms) was used for screening and structural elucidation of core oligosaccharides isolated from lipopolysaccharides of bacteria of the genus proteus. mass spectra allowed the determination of the molecular masses with high accuracy and the estimation of the chemical heterogeneity of the samples. they did not, however, provide sufficient information to identify structural details of the branched oligos ...200516041825
lymphocytic colitis: a clue to bacterial etiology.to find out the role of bacteria as a possible etiological factor in lymphocytic colitis.200516437626
detection and identification of intestinal pathogenic bacteria by hybridization to oligonucleotide microarrays.to detect the common intestinal pathogenic bacteria quickly and accurately.200516437687
[evaluation of the antimicrobial potential of immune sera].the inhibiting activity of blood sera obtained from 20 volunteers immunized with the multi-component vaccine "pyopol", 25 nonimmune donors and 7 lots of human antistaphylococcal immunoglobulin with respect to staphylococcus aureus, escherichia coli, proteus vulgaris and pseudomonas aeruginosa has been studied in the liquid nutrient medium with the use an automated microbiological analyzer. the sera of donors immunized with the vaccine "pyopol" have been found to possess high antimicrobial activi ...200516438372
[influence of dendrite cells, generated with the use of immunomodulators of microbial origin, on the proliferative and cytotoxic activity of lymphocytes].the influence of ripe dendrite cells (dc) on the proliferative activity of mononuclear leukocytes and the cytotoxic activity of lymphocytes of syngenic mice was studied. as inducers of dc ripening, the combination of antigenic components incorporated into the vaccine "lmmunovac bh-4", (klebsiella pneumoniae, proteus vulgaris, escherichia coli, staphylococcus aureus), as well as k. pneumoniae lps and tnf-alpha, were used. this study demonstrated that dc activated with these preparations enhanced ...200516438373
windblown foot: a particular presentation of proteus syndrome? 200516440890
erythromycin synergism with essential and trace elements.in order to establish the role of various essential and trace element complexation on the antibacterial activity of various macrolide antibiotics, the synergistic or antagonistic behavior of erythromycin metal complexes have been studied and compared with the parent drug. metal complexes of erythromycin with magnesium, calcium, chromium, manganese, iron, cobalt, nickel, copper, zinc and cadmium have been investigated for their antibacterial activity and compared with erythromycin by observing th ...200516431396
[rare bacteria species found in wounds of tsunami patients. predominance of gram-negative rods, increased antibiotic resistance].microbiological cultures from 229 patients seeking medical advise in stockholm after the tsunami catastrophe december 2004 were analysed at the clinical microbiology laboratory, karolinska university hospital, stockholm, sweden. gram-negative rods were the most common findings from wound cultures. common human pathogens as escherichia coli, proteus species, klebsiella spp, and pseudomonas aeruginosa were isolated. however, more rare species of gram-negative rods were also isolated, e.g. myroides ...200516416946
a study of sensitivity and resistance of pathogenic micro organisms causing uti in kathmandu valley.a retrospective study was conducted in five hospitals to observe the prevalence of organisms causing uti and their sensitivity to antibiotics. methodology: altogether, data from five hundred samples of urine from five hospitals in kathmandu was collected for this study from january 2005 to april 2005. result: a total of 244 samples were found to be positive. altogether six types of organisms were isolated as the causative factors. e. coli (49%), s. aureus, (coagulase positive) (23%), proteus spe ...200516415607
[problems of epidemic safety of drinking water use by the population of russia].quantitative relationships were studied between the indicators (common coliform bacteria (ccp), glucose-positive bacteria (gpb), thermoduric bacteria (tdb), coliform bacteria, enterococci, clostridia, coliphages) and the opportunistic (pseudomonas aeruginosa, proteus, klebsiella) and pathogenetic (salmonella and intestinal viruses) microorganisms at the stages of effluent purification and decontamination, in processes of self-purification in the water reservoirs and of water preparation at water ...200516404875
serological classification and epitope specificity of proteus penneri s29 lipopolysaccharide.gram-negative bacteria of genus proteus are common human intestinal and urinary tract pathogens. in the genus proteus there are four clinically important named species: p. mirabilis, p. vulgaris, p. penneri, and p. hauseri, and three unnamed proteus genomospecies: 4, 5, and 6. the clinical significance of p. penneri, described in 1982 as a new species, is poorly documented. the aim of this work is serological characterization and classification of a ceftriaxone-susceptible p. penneri s29 strain ...200516407787
acute uncomplicated lower urinary tract infections in general practice: clinical and microbiological cure rates after three- versus five-day treatment with trimethoprim.epidemiological studies indicate that acute uncomplicated urinary tract infections (uti) in women can be successfully treated with short treatment regimens. however, the findings from the literature do not match experiences in daily practice.200516392777
unilateral proteus syndrome.proteus syndrome is a complex developmental abnormality. it is characterized by both hypertrophic and hypoplastic changes. deformities have been occasionally found to be localized in one half of the body in head or digit but presence of all signs in one half of the body in a wide spread manner is not reported in the literature. we report the case for its unusual presentation of unilateral localization of signs.200516394389
proteus syndrome.proteus syndrome is a variable and complex disorder characterized by multifocal overgrowths affecting any tissue or structure of the body. we present a girl aged 3 years and 8 months with an epidermal nevus, port-wine stain, macrodactyly with gigantism of the feet, lymphohemagiomas and multiple lipomas.200516394465
update on the molecular genetics of vascular anomalies.genetic factors play a critical role in the pathogenesis of vascular anomalies. significant advances have been made in recent years in identifying the genetic and molecular determinants of a variety of vascular anomalies using a molecular genetic approach. several genes for vascular anomalies have been identified. these genes include aggf1 for klippel-trenaunay syndrome, rasa1 for capillary malformations, krit1, mgc4607, pdcd10 for cerebral cavernous malformations, glomulin for glomuvenous malfo ...200516379592
antimicrobial activity of flavonoids from pelargonium radula (cav.) l'hérit.flavonoids from pelargonium radula (cav.) l'hérit were purified by column chromatography. two fractions were obtained: f1 (main flavonoid isoquercitrin) and f2 (main flavonoid rutin). in vitro antimicrobial activity of f1 and f2 were tested against eleven species of bacteria and eleven species of fungi. both fractions demonstrated strong inhibitory activity against staphylococcus aureus, proteus rettgeri, candida tropicalis and microsporum gypseum. staphylococcus sp. (coagulase-negative) and can ...200516375833
assessment of antibacterial activity of some topical otological solutions.otological solutions have long been used in the treatment of the bacterial and fungal infections of the ear. we investigated antibacterial activity of some otic solutions against the most common bacteria isolated from discharging ears.200516340276
hsp60 expression during carcinogenesis: a molecular "proteus" of carcinogenesis? 200516333979
in-vitro antibacterial and cytotoxic activity of cobalt (ii), copper (ii), nickel (ii) and zinc (ii) complexes of the antibiotic drug cephalothin (keflin).keflin (kefl) interacts with co(ii), cu(ii), ni(ii) and zn(ii) metal ions leading to complexes of the type m(kefl)2cl2 and m(kefl)cl2, which have been characterized by physicochemical and spectroscopic methods. magnetic moment, ir, electronic spectral and elemental analyses data suggest that keflin behaves tridentately forming octahedral or trigonal bipyramidal complexes with the metal ions mentioned above. the new compounds have been screened in-vitro for antibacterial and cytotoxic activity ag ...200516335054
comparative antimicrobial potency of meropenem tested against gram-negative bacilli: report from the mystic surveillance program in the united states (2004).the meropenem yearly susceptibility test information collection (mystic) program is a longitudinal resistance surveillance network of more than 100 medical centers worldwide monitoring the susceptibility of bacterial pathogens to carbapenems and other broad-spectrum agents. in 2004 (year six), the antimicrobial activity of 12 broad-spectrum agents was assessed against 2,799 gram-negative bacterial isolates submitted from 15 united states (usa) medical centers using clinical and laboratory standa ...200516323433
case analysis of purple urine-bag syndrome at a long-term care service in a community hospital.purple urine-bag syndrome (pubs) is a rare phenomenon in which the contents of urine bags turn purple or blue following patient catheterization. the condition often causes care givers tremendous distress. we investigated the prevalence and possible causes of pubs for a group of elderly patients.200516323555
proteus syndrome with giant myelolipoma in the pelvis.proteus syndrome is a very rare and complex disorder with malformations and overgrowth of multiple tissues. this disorder was designated proteus syndrome by wiedemann et al. to denote its variable clinical expression. our patient presented with macrodactyly, cerebriform appearance and a huge abdominal mass. a biopsy under laparotomy was performed, and histopathological examination revealed myelolipoma. tumor resection was performed. to our knowledge, no case of proteus syndrome presenting a myel ...200516351661
determination of the antimicrobial properties of oligo-2-hydroxy-1-naphthaldehyde.oligo-2-hydroxy-1-naphthaldehyde (ohna) was synthesized by oxidative polycondensation using h2o2 (35%, aqueous solution), air o2 and naocl (34%, aqueous solution) by kaya and senol and the products were characterized by spectral techniques. antimicrobial activities of the first and second fractions of ohna were tested against corynobacterium xerosis ccm 2824, proteus vulgaris atcc 6897, staphylococcus epidermidis nrrl b-4877, s. aureus atcc 6538, enterobacter aerogenes atcc 13048, salmonella thy ...200516355978
in vitro activities of tigecycline, ertapenem, isepamicin, and other antimicrobial agents against clinically isolated organisms in taiwan.this study evaluated the in vitro activities of tigecycline, ertapenem, isepamicin, and other comparators against 861 bacterial isolates recovered from patients treated in three major teaching hospitals in 2003. mics to antimicrobial agents were determined by the agar dilution method. high rates of oxacillin resistance (58%) in staphylococcus aureus (60 isolates), and vancomycin resistance (21%) and quinupristin-dalfopristin non-susceptibility (39%) in enterococcus faecium (34 isolates) were fou ...200516359192
ctx-m-1 extended-spectrum beta-lactamase-producing proteus mirabilis in greece.to examine the dissemination of ctx-m-type extended-spectrum beta-lactamases (esbls) in clinical isolates of proteus mirabilis, 91 nonrepetitive esbl-producing p. mirabilis were collected from infected patients in a tertiary greek hospital during september, 2001, to may, 2004. a bla (ctx-m) gene was amplified in one isolate (strain a328), but bla (ctx-m) was not detected in any of the remaining esbl producers. sequencing results showed that p. mirabilis a328 produced a ctx-m-1 enzyme while pcr m ...200516359194
neurocutaneous syndromes and epilepsy-issues in diagnosis and management.epilepsy may be seen as a feature of many of the neurocutaneous syndromes. the challenge lies within the diagnosis of the specific disorder and ultimately control of the epilepsy. tuberous sclerosis is the most common of the disorders with a frequency of 4.9/100,000. an autosomal-dominant condition, diagnostic features may be unclear under 2 years of age. population studies suggest a prevalence of epilepsy of 78%, the majority presenting under the age of 12 months, with a high association betwee ...200516359466
differential activity of a lectin from solieria filiformis against human pathogenic bacteria.a lectin isolated from the red alga solieria filiformis was evaluated for its effect on the growth of 8 gram-negative and 3 gram-positive bacteria cultivated in liquid medium (three independent experiments/bacterium). the lectin (500 microg/ml) stimulated the growth of the gram-positive species bacillus cereus and inhibited the growth of the gram-negative species serratia marcescens, salmonella typhi, klebsiella pneumoniae, enterobacter aerogenes, proteus sp, and pseudomonas aeruginosa at 1000 m ...200516302091
lunatusin, a trypsin-stable antimicrobial peptide from lima beans (phaseolus lunatus l.).an anti-fungal peptide designated as lunatusin, with a molecular mass around 7kda, was purified from the seeds of chinese lima bean (phaseolus lunatus l.). the peptide was isolated using a simple protocol consisting of affinity chromatography on affi-gel blue gel and gel filtration on superdex 75. lunatusin exerted an anti-fungal activity toward fungal species such as fusarium oxysporum, mycosphaerella arachidicola and botrytis cinerea, and an antibacterial action on, bacillus megaterium, bacill ...200516269344
relationships between antimicrobial use and antimicrobial resistance in gram-negative bacteria causing nosocomial infections from 1991-2003 at a university hospital in taiwan.this study was conducted to evaluate the relationship between antimicrobial resistance and antimicrobial use in a university hospital in taiwan. disk susceptibility data of escherichia coli, klebsiella pneumoniae, enterobacter cloacae, serratia marcescens, proteus spp., pseudomonas aeruginosa, acinetobacter spp., stenotrophomonas maltophilia and other non-fermentative gram-negative bacilli causing nosocomial infections were evaluated. data on annual patient-days and annual consumption (defined d ...200516280243
microbiology of dacryocystitis among adults population in southern australia.retrospective study on microbiology of dacryocystitis cases in adults was carried out at the royal victorian eye and ear hospital (rveeh). sixty-four consecutive cases seen between march 2000 and june 2003 were included. seventy-nine organisms were isolated from the sixty-six samples (1.2/specimen). aerobic or facultative bacteria were recovered in 76 (96.2), fungi from two specimens (2.5%). and anaerobic bacteria from only one specimen (1.3%). staphylococcus aureus (27), was most common followe ...200516295714
structures of the o-polysaccharides and classification of proteus genomospecies 4, 5 and 6 into respective proteus serogroups.an acidic branched o-polysaccharide was isolated by mild acid degradation of the lipopolysaccharide (lps) of proteus genomospecies 4 and studied by sugar and methylation analyses along with 1h and 13c nmr spectroscopy, including 2d cosy, tocsy, roesy and h-detected 1h, 13c hsqc experiments. the following structure of the pentasaccharide repeating unit of the o-polysaccharide was established, which is unique among proteus polysaccharide structures: [structure: see text] where qui3nac stands for 3 ...200516262693
bacterial flora of the low male genital tract in patients consulting for infertility.the physiological aerobic bacterial flora of the low male genital tract was determined. this prospective study was performed on 600 semen specimens collected from 543 asymptomatic males consulting for infertility. semen cultures were sterile in 28.8%, with a polymicrobial flora and/or absence or low titres of ureaplasma urealyticum in 49.3%, and with one or two aerobic and facultative bacteria > or =1 x 10(3) cfu ml(-1) and/or u. urealyticum with titres > or =10(4) ccu ml(-1) (colour changing un ...200516266393
antimicrobial activity of some medicinal plants from india.the results of a preliminary antimicrobial screening of the methanol extracts of zingiber officinale, asteracantha longifolia, citrus acida, salacia microsperma and tinospora cordifolia are reported.200516229969
bacteriological urinalysis in patients after renal transplantation.the study consisted of microbiological urinalysis performed in 269 patients after renal transplantation who remained under medical care at the outpatient service of the transplantation institute in warsaw. the patients enrolled into the study had undergone renal transplantation 6 to 72 months before urine samples were collected. 304 urinalysis were performed. in the group of 269 patients, 42 individuals had bacteria in their urine what was confirmed in 47 urine cultures. cases of bacteriuria wer ...200516599304
[comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (2003). i. susceptibility distribution].the bacterial strains isolated from 565 patients diagnosed as having urinary tract infections (utis) in 14 institutions in japan were collected between august 2003 and july 2004. the susceptibilities of them to many kinds of antimicrobial agents were investigated. of them, 701 strains were estimated as prophlogistic bacteria and used for the investigation. the strains consisted of 258 gram-positive bacterial strains (36.8%) and 443 gram-negative bacterial strains (63.2%). against staphylococcus ...200516521344
[nationwide surveillance of parenteral antibiotics containing meropenem activities against clinically isolated strains in 2004].the antibacterial activity of meropenem (mepm) and other parenteral antibiotics against clinical isolates of 907 strains of gram-positive bacteria, 1790 strains of gram-negative bacteria, and 192 strains of anaerobic bacteria obtained from 30 medical institutions during 2004 was measured. the results were as follows; 1. mic90 of mepm for almost all of enterobacteriaceae and haemophilus influenzae were 4-fold to 32-fold lower than those of other carbapenems. mepm was more active than other carbap ...200516521347
[necrotizing fasciitis of the head and neck].necrotizing fasciitis (nf) is a potentially lethal soft tissue infection characterized by cutaneous necrosis, suppurative fasciitis, vascular thrombosis and extreme systemic toxicity. it is a rare entity in the head and neck region, but occur most frequently in patients with diabetes and chronic alcoholism. mostly involved are immunodeficient patients with banal infections of the upper aerodigestive tract, small traumas, but also after surgical procedures. necrotizing fasciitis is an infection c ...200516521446
crystallization of truncated hemolysin a from proteus mirabilis.proteus species are second only to escherichia coli as the most common causative agent of gram-negative bacteria-based urinary-tract infections and many harbor several virulence factors that provide inherent uropathogenicity. one virulence factor stems from a two-partner secretion pathway comprised of hemolysin a and hemolysin b; upon hemolysin b-dependent secretion, hemolysin a becomes activated. this system is distinct from the classic type i secretion pathway exemplified by the hemolysin syst ...200516511066
mechanical transmission of pathogenic organisms: the role of cockroaches.cockroaches (diploptera punctata) are basically tropical insects and will do their best to find a home that is both warm and moist. their involvement in the transmission of tropical diseases is poorly investigated in africa.200516457381
aerobic heterotrophic bacterial diversity in sediments of rajakkamangalam estuary, south west coast of india.the abundance of aerobic heterotrophic bacterial population in the sediment sample of six experimental stations (s1 to s6) at rajakkamangalam estuary was studied for a period of one year from march, 1998 to february, 1999. the important bacterial genera encountered were pseudomonas, bacillus, vibrio, escherichia, micrococcus, enterobacter, salmonella, aeromonas, shigella, klebsiella, proteus, alkaligenes, staphylococcus, citrobacter and flavobacterium. the bacterial population based on numerical ...200516459565
misdiagnosis of neurofibromatosis type 1 as proteus syndrome. 200516462730
capillary activity of surgical sutures and suture-dependent bacterial transport: a qualitative study.to evaluate the multitude of new synthetic absorbable sutures (both monofilament and multifilament) in comparison with older materials with regard to capillarity and bacterial transport.200516433602
pharmacodynamic modeling of imipenem-cilastatin, meropenem, and piperacillin-tazobactam for empiric therapy of skin and soft tissue infections: a report from the optama program.the bactericidal exposures necessary for positive clinical outcomes among skin and soft tissue infections are largely dependent on interpatient pharmacokinetic variability and pathogen drug susceptibility. by simulating the probability of achieving target bactericidal exposures, the pharmacodynamics of three beta-lactam agents were compared against a range of pathogens implicated commonly in complicated skin and soft tissue infections.200516433606
increasing incidence of bacterial, resistance to antibiotics by isolates from the urinary tract.this is a prospective study to determine the prevalence of antibiotic resistance among organisms causing urinary tract infections in a teaching hospital between august 2003 and july 2004 and to compare them with an earlier study in 1993. a total of 1,104 urine samples were collected in sterile universal containers from patients attending university of nigeria teaching hospital and studied. all samples showing significant bacteriuna were studied and isolates identified using standard bacteriogica ...200516477864
contribution of the two conserved tryptophan residues to the catalytic and structural properties of proteus mirabilis glutathione s-transferase b1-1.pmgstb1-1 (proteus mirabilis glutathione s-transferase b1-1) has two tryptophan residues at positions 97 and 164 in each monomer. structural data for this bacterial enzyme indicated that trp97 is positioned in the helix a4, whereas trp164 is located at the bottom of the helix a6 in the xenobiotic-binding site. to elucidate the role of the two tryptophan residues they were replaced by site-directed mutagenesis. trp97 and trp164 were mutated to either phenylalanine or alanine. a double mutant was ...200515320869
clinical evaluation of postpartum vaginal mucus reflects uterine bacterial infection and the immune response in cattle.bacteria contaminate the uterus of most dairy cattle after parturition and endometritis causes infertility. an endometritis score can be ascribed based on the vaginal mucus character and odour but it is not clear if the clinical score reflects the number of uterine bacteria or the inflammatory response. the present study tested the hypothesis that clinical evaluation of endometritis reflects the number of bacteria present in the uterus, and the acute phase protein response. swabs (n = 328) were ...200515589277
does the valve regulated release of urine from the bladder decrease encrustation and blockage of indwelling catheters by crystalline proteus mirabilis biofilms?we tested whether valve regulated, intermittent flow of urine from catheterized bladders decreases catheter encrustation.200515592093
evaluation of a new screen agar plate for detection and presumptive identification of enterobacteriaceae producing extended-spectrum beta-lactamases.a new agar screen plate for extended-spectrum beta-lactamase (esbl) detection was evaluated with 50 clinical isolates of esbl-producing enterobacteriaceae species: enterobacter cloacae (n = 10), escherichia coli (n = 10), klebsiella oxytoca (n = 3), klebsiella pneumoniae (n = 25), and proteus mirabilis (n = 2). fecal samples were artificially inoculated with 2 concentrations (25 and 250 colony forming units [cfu]/plate) of the test strains and then applied to the new agar screen plates. by this ...200515629229
nature of the promoter activated by c.pvuii, an unusual regulatory protein conserved among restriction-modification systems.a widely distributed family of small regulators, called c proteins, controls a subset of restriction-modification systems. the c proteins studied to date activate transcription of their own genes and that of downstream endonuclease genes; this arrangement appears to delay endonuclease expression relative to that of the protective methyltransferase when the genes enter a new cell. c proteins bind to conserved sequences called c boxes. in the pvuii system, the c boxes have been reported to extend ...200515629920
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