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osteomyelitis and osteonecrosis after intraosseous perfusion with gentamicin.to describe and discuss previously unreported complications associated with intraosseous perfusion with gentamicin in horses. study201020459490
antimicrobial susceptibility and beta-lactamase production of selected gram-negative bacilli from two croatian hospitals: mystic study results.the meropenem yearly susceptibility test information collection (mystic) programme is a global, longitudinal resistance surveillance network that monitors the activity of meropenem and compares its activity with other broadspectrum antimicrobial agents. we now report the antimicrobial efficacy of meropenem compared to other broad-spectrum agents within the selective gram-negative pathogen groups from two croatian hospitals investigated between 2002-2007. a total of 1510 gram-negative pathogens w ...201020566417
chromosomally encoded blacmy-2 located on a novel sxt/r391-related integrating conjugative element in a proteus mirabilis clinical isolate.integrating conjugative elements (ices) are mobile genetic elements that can transfer from the chromosome of a host to the chromosome of a new host through the process of excision, conjugation, and integration. although sxt/r391-related ices, originally demonstrated in vibrio cholerae o139 isolates, have become prevalent among v. cholerae isolates in asia, the prevalence of the ices among gram-negative bacteria other than vibrio spp. remains unknown. in addition, sxt/r391-related ices carrying g ...201020566768
synthesis and antimicrobial activities of some quaternary morpholinium chlorides.the synthesis and antimicrobial activity of 31 morpholinium chlorides, divided into five series depending on the substituents attached to the nitrogen atom, n-carboxyalkyl-morpholinium chlorides (1a-e), n-carbalkoxymethyl-n-methyl-morpholinium chlorides (2a-f), n-carbethoxymethyl-n-alkyl-morpholinium chlorides (3a-g), n-carbalkoxymethyl-n-dodecyl-morpholinium chlorides (4a-f) and n-carboxymethyl-n-alkyl-morpholinium chlorides (5a-g) is reported. the compounds investigated were tested for antimic ...201020568530
bacterial contamination of boar semen affects the litter size.one hundred and fifteen semen samples were collected from 115 different boars from two farms in cuba. the boars belonged to five different breeds. evaluation of the semen sample characteristics (volume, ph, colour, smell, motility of sperm cells) revealed that they meet international standards. the samples were also tested for the presence of agglutinated sperm cells and for bacterial contamination. seventy five percent of the ejaculates were contaminated with at least one type of bacteria and e ...201020427136
development of an oregano-based ointment with anti-microbial activity including activity against methicillin-resistant staphlococcus aureus.increasing antibiotic resistance has prompted a search for new compounds with anti-microbial activity. in the authors' previous study, oregano extract was identified as one of the most potent anti-microbial compounds. the disk diffusion method was employed to assess the degree of inhibition against various microorganisms, and the bacteriostatic or bactericidal mechanism of action. disk diffusion studies showed that oregano was found to be bacteriostatic for staphylococcus aureus (s. aureus) and ...201020514796
[a case of large vesicourethral stone resulting from long-term retention of a foley catheter].we report a case of a large vesicourethral stone resulting from a long-term indwelling urethral catheter. a 66-year-old man visited our hospital emergency room on october 24, 2006 with a chief complaint of difficult urination. although a urethral catheter was inserted temporarily based on the diagnosis of the doctor on duty, the patient did not return to our hospital for follow-up examination. on july 10, 2008, he was wheeled into our hospital with symptoms of general fatigue, urinary retention ...201020519926
transcriptome of swarming proteus mirabilis.swarming motility by the urinary tract pathogen proteus mirabilis has been a long-studied but little understood phenomenon. on agar, a p. mirabilis colony grows outward in a bull's-eye pattern formed by consecutive waves of rapid swarming followed by consolidation into shorter cells. to examine differential gene expression in these growth phases, a microarray was constructed based on the completed genome sequence and annotation. rna was extracted from broth-cultured, swarming, and consolidation- ...201020368347
the encrustation and blockage of long-term indwelling bladder catheters: a way forward in prevention and control.to review the literature showing that understanding how foley catheters become encrusted and blocked by crystalline bacterial biofilms has led to strategies for the control of this complication in the care of patients undergoing long-term indwelling bladder catheterization.201020368711
from proteus to prometheus: learning from fish to modulate regeneration. 201020378822
loss of the waal o-antigen ligase prevents surface activation of the flagellar gene cascade in proteus mirabilis.proteus mirabilis is a gram-negative bacterium that undergoes a physical and biochemical change from a vegetative swimmer cell (a typical gram-negative rod) to an elongated swarmer cell when grown on a solid surface. in this study, we report that a transposon insertion in the waal gene, encoding o-antigen ligase, blocked swarming motility on solid surfaces but had little effect on swimming motility in soft agar. the waal mutant was unable to differentiate into a swarmer cell. differentiation was ...201020382766
zinc uptake contributes to motility and provides a competitive advantage to proteus mirabilis during experimental urinary tract infection.proteus mirabilis, a gram-negative bacterium, represents a common cause of complicated urinary tract infections in catheterized patients or those with functional or anatomical abnormalities of the urinary tract. znub, the membrane component of the high-affinity zinc (zn(2+)) transport system znuacb, was previously shown to be recognized by sera from infected mice. since this system has been shown to contribute to virulence in other pathogens, its role in proteus mirabilis was investigated by con ...201020385754
antibacterial and antifungal activities of (beta)-carboline alkaloids of peganum harmala (l) seeds and their combination effects.the β-carboline alkaloids of peganum harmala l were extracted through a bioassay-guided fractionation and their antimicrobial activities were investigated. results revealed significant differences (p>0.05) between compounds depending on the microorganism tested and the application method. when examined individually, harmine was the most effective against proteus vulgaris, bacillus subtilis and candida albicans where inhibition zones ranged between 21.2 and 24.7 mm. potentiality of the alkaloids ...201020398742
decolorization and biodegradation of reactive dyes and dye wastewater by a developed bacterial consortium.a bacterial consortium (consortium gr) consisting of proteus vulgaris ncim-2027 and micrococcus glutamicus ncim-2168 could rapidly decolorize and degrade commonly-used sulfonated reactive dye green he4bd and many other reactive dyes. consortium gr shows markedly higher decolorization activity than that of the individual strains. the preferable physicochemical parameters were identified to achieve higher dye degradation and decolorization efficiency. the supplementation of cheap co-substrates (e. ...201020407917
comparative in vitro activity of cefditoren and other antimicrobials against enterobacteriaceae causing community-acquired uncomplicated urinary tract infections in women: a spanish nationwide multicenter study.cefditoren is a third-generation orally administered cephalosporin with a broad spectrum of activity against gram-positive and gram-negative bacterial species. after an oral 400-mg single dose, the mean concentrations in urine are 186.5 mg/l at 2 to 4 h and 12.7 mg/l at 8 to 12 h, and it is a potential drug to be used in the treatment of urinary tract infection (uti). we performed a multicenter nationwide study in spain in order to determine the in vitro activity of cefditoren and other comparat ...201020542206
[detection of bla(ctx-m) beta-lactamase genes in extended-spectrum beta-lactamase producing gram-negative bacteria].widespread production of ctx-m type extended-spectrum beta-lactamases (esbl) in enterobacteriaceae strains which are resistant to extended-spectrum cephalosporins is the most remarkable example for rapid and global spread of plasmid mediated antimicrobial resistance in bacteria. consecutive 200 esbl producing enterobacteriaceae strains out of 1640 isolates that were obtained from clinical samples (167 urine, 11 wound, 7 bronchoalveolar lavage, 3 peritoneal fluid, 2 cerebrospinal fluid, 2 biopsy, ...201020549952
triblock copolymer matrix-based capillary electrophoretic microdevice for high-resolution multiplex pathogen detection.rapid and simple analysis for the multiple target pathogens is critical for patient management. ce-sscp analysis on a microchip provides high speed, high sensitivity, and a portable genetic analysis platform in molecular diagnostic fields. the capability of separating ssdna molecules in a capillary electrophoretic microchannel with high resolution is a critical issue to perform the precise interpretation in the electropherogram. in this study, we explored the potential of poly(ethyleneoxide)-pol ...201020309929
microbial colonization of tracheoesophageal voice prostheses (provox2) following total laryngectomy.the purpose of this study was to determine the presence of individual microorganisms and the most frequent microbial combinations in the biofilm of the indwelling provox2 voice prosthesis in situ. furthermore, we wanted to evaluate the possible influence of biofilm composition on the mean and median lifetime of these voice prostheses. over a 5-year period, implantation of a provox2 voice prosthesis was performed in 85 patients, or 90% of the overall number of patients who underwent total larynge ...201020432044
neurognostics question. metamorphosis of a man: diagnosing joseph merrick. proteus syndrome. 201020446160
synthesis, antibacterial activity evaluation and qsar studies of novel dispiropyrrolidines.a series of novel dispiropyrrolidines have been synthesized through 1,3-dipolar cycloaddition of an azomethine ylide generated from sarcosine and isatin with the dipolarophile 3-benzylidene-1-methyl-pyrrolidine-2,5-dione. their antibacterial activity was evaluated against bacillus subtilis ncim 2718, staphylococcus aureus ncim5021, salmonella typhi ncim2501, pseudomonas aeruginosa ncim 5029 and proteus vulgaris ncim2813 by two fold dilution method. compound 6e exhibits reasonably good activity a ...201020556891
generation of chitin-derived oligosaccharides toxic to pathogenic bacteria using chia74, an endochitinase native to bacillus thuringiensis.to demonstrate that an endochitinase (chia74) native to bacillus thuringiensis can be used to generate chitin-derived oligosaccharides (ogs) with antibacterial activity against a number of aetiological agents of disease, including bacteria that cause diarrhoeal and emetic syndromes in humans.201020557451
antimicrobial activity and a sar study of some novel benzimidazole derivatives bearing hydrazone moiety.in this study 12 novel benzimidazole compounds bearing hydrazone moiety were synthesized in order to investigate their possible antibacterial and antifungal activity. structures of the synthesized compounds were elucidated by spectral data. six different gram-negative and four different gram-positive bacterial strains were used in antibacterial activity tests. antifungal activity tests were also performed against three different fungal strains. most of the test compounds found to be significantl ...201020451306
performance of the oxoid m.i.c.evaluator strips compared with the etest assay and bsac agar dilution.the oxoid m.i.c.evaluator (m.i.c.e; thermo fisher scientific) comprises an antibiotic gradient on a plastic support. we compared its performance with etest--a similar product--using bsac agar dilution as a reference.201020562429
identification and antimicrobial susceptibility patterns of bacteria causing otitis externa in dogs.bacterial agents are considered important pathogens causing external otitis in dogs. it is essential to carry out bacterial culture and antimicrobial susceptibility test in the case of otitis externa, particularly for chronic or recurring cases. sterile swab samples were obtained from terminal part of vertical ear canals of 74 dogs with otitis externa for cytology, bacterial culture and antimicrobial susceptibility test. cytologic smears were stained using gram and giemsa staining methods. aerob ...201020526674
determinants of beta-lactam resistance in meningitis-causing enterobacteriaceae in brazil.this study analyzed resistance determinants in extended-spectrum beta-lactamase (esbl)-producing enterobacteria and the epidemiology of 11 escherichia coli isolates obtained from meningitis patients in a region of brazil from 2000 to 2005. esbl-encoding genes and their genetic environment were investigated by pcr and sequencing. the gene blactx-m-2 was identified in 3 different enterobacteria (e. coli, serratia marcescens, and proteus mirabilis) downstream of the insertion sequence iscr1 (locali ...201020555402
prevalence of asymptomatic bacteriuria in type 2 diabetic subjects with and without microalbuminuria.abstract:201020565718
emergence of proteus mirabilis isolates producing tem-52 extended-spectrum beta-lactamases in croatia.an increased frequency of extended-spectrum beta-lactamase (esbl)-positive proteus mirabilis isolates was observed recently in the clinical hospital center split in croatia. the aim of this study was the molecular characterization of esbls in p. mirabilis isolates from this hospital.201020551637
production of biogenic amines "in vitro" in relation to the growth phase by enterobacteriaceae species isolated from traditional sausages.histidine, lysine, ornithine and tyrosine decarboxylase activities were tested in 79 strains of enterobacteriaceae (41 of hafnia alvei, 17 of serratia liquefaciens, 5 of enterobacter cloacae, 4 of citrobacter braakii, 2 of proteus vulgaris, 2 of proteus mirabilis, 2 of providencia stuartii, 2 of klebsiella terrigena, 1 of rahnella aquatilis, 1 of salmonella arizonae, 1 of citrobacter youngae and 1 of escherichia coli) isolated from botillo, a spanish traditional sausage. in general, the strains ...201020673614
predictors, treatment, and outcomes of non-pseudomonas gram-negative peritonitis.non-pseudomonas gram-negative (npgn) peritonitis is a frequent, serious complication of peritoneal dialysis; however, previous reports have been limited to small, single-center studies. to gain insight on the frequency, predictors, treatment, and outcomes of npgn peritonitis, we analyzed data in the anzdata registry of all adult australian peritoneal dialysis patients over a 39-month period using multivariate logistic and multilevel poisson regressions. there were 837 episodes of npgn peritoniti ...201020505659
most frequent causes of urinary tract infections in children.to determine the most frequent causes of urinary tract infection (uti) amongst children according to gender and age.201020514772
the group of epidermal nevus syndromes part i. well defined phenotypes.the epidermal nevus syndromes represent a group of distinct disorders that can be distinguished by the type of associated epidermal nevus and by the criterion of presence or absence of heritability. well defined syndromes characterized by organoid epidermal nevi include schimmelpenning syndrome, phacomatosis pigmentokeratotica, nevus comedonicus syndrome, angora hair nevus syndrome, and becker nevus syndrome. the molecular basis of these disorders has so far not been identified. by contrast, the ...201020542174
[cloning and expression of non-position-specific lipase gene from proteus vulgaris].to produce proteus vulgaris lipase (pvl) in large quantities, we cloned and expressed the lipase gene in escherichia coli.201020687340
[evaluation of the antimicrobial susceptibility profile of microorganisms isolated from urine in the region of vale do sousa and tâmega].the urinary tract is one of the more common sites of bacterial infections, especially in women. urinary infection can be defined as an infection of urinary tract structures which occurs, generally, as a consequence of the presence or colonization by urine bacteria. the aim of this study was to determine the etiology of urinary tract infections and their susceptibility to antimicrobial agents in the region of vale do sousa and tâmega. from february 2008 to january 2009, 18653 urine cultures were ...201020687992
the group of epidermal nevus syndromes part ii. less well defined phenotypes.in addition to the well established epidermal nevus syndromes, such as schimmelpenning, becker, proteus, child, or nevus comedonicus syndromes, the group of less well defined phenotypes associated with epidermal nevi presently includes nevus trichilemmocysticus syndrome, didymosis aplasticosebacea, scalp syndrome (sebaceous nevus, central nervous system malformations, aplasia cutis congenita, limbal dermoid,and pigmented nevus), gobello syndrome, bäfverstedt syndrome, nevada syndrome (nevus epid ...201020542175
chemical composition of the sfe-co extracts from cajanus cajan (l.) huth and their antimicrobial activity in vitro and in vivo.the in vitro and in vivo antimicrobial activities of sfe-co₂(supercritical fluid extraction) extracts and ethanol extracts from cajanus cajan (l.) huth were investigated. the flavonoid compounds orientin, vitexin, isovitexin, pinostrobin and the stilbene cajaninstilbene acid were detected in sfe-co₂ extracts by hplc-dad. in vitro antimicrobial activities of the extracts were evaluated against eight microbial strains (the bacteria staphylococcus epidermidis, staphylococcus aureus, bacillus subtil ...201020576412
[characteristic features of urinary tract infection in malnourished children].the aim of this study is to prove a relationship between urinary tract infection and malnutrition in children 0-3 years old, hospitalized in the ivi pediatric clinic, hospital st. mary iaşi, between january 2000 and december 2004.201020700977
antimicrobial susceptibility of bacteria isolated from inpatients and outpatients urine samples.antibacterial resistance is generally regarded as a public health problem, not only in local terms, but also worldwide. the objective of this research work would be to analyze inpatient's and outpatient's antimicrobial resistance to a set of various agents. the patients have been medically treated in the region of ze-do canton since 2005 until today. total number of 164 patients was included in our research. regarding the place of medical treatment, our patients were divided into two groups: a t ...201020645510
extension of an infectious abdominal aneurysm into the l3 and l4 vertebrae: report of a difficult case. 201020149710
survival of campylobacter jejuni under conditions of atmospheric oxygen tension with the support of pseudomonas spp.campylobacter jejuni is a major food-borne pathogen. despite causing enteritis in humans, it is a well-adapted intestinal microorganism in animals, hardly ever generating disease symptoms. nevertheless, as a true microaerophilic microorganism it is still puzzling how campylobacter cells can survive on chicken meat, the main source of human infection. in this study, we demonstrate that c. jejuni is able to withstand conditions of atmospheric oxygen tension when cocultured with pseudomonas species ...201020639377
theoretical study of the catalytic mechanism of dna-(n4-cytosine)-methyltransferase from the bacterium proteus vulgaris.in this paper the reaction mechanism for methylation of cytosine at the exocyclic n4 position catalyzed by m.pvuii has been explored by means of hybrid quantum mechanics/molecular mechanics (qm/mm) methods. a reaction model was prepared by placing a single cytosine base in the active site of the enzyme. in this model the exocyclic amino group of the base establishes hydrogen bond interactions with the hydroxyl oxygen atom of ser53 and the carbonyl oxygen atom of pro54. the reaction mechanism inv ...201020524651
screening of antibacterial activity of mucus extract of snakehead fish, channa striatus (bloch).the objective of this study is to gain a better understanding of the antimicrobial properties of the mucus extract of snakehead fish, channa striatus against selected human and fish pathogenic microbes.201020707287
synthesis, antibacterial activity evaluation and qsar studies of novel dispiropyrrolidines.a series of novel dispiropyrrolidines have been synthesized through 1,3-dipolar cycloaddition of an azomethine ylide generated from sarcosine and isatin with the dipolarophile 3-benzylidene-1-methyl-pyrrolidine-2,5-dione. their antibacterial activity was evaluated against bacillus subtilis ncim 2718, staphylococcus aureus ncim5021, salmonella typhi ncim2501, pseudomonas aeruginosa ncim 5029 and proteus vulgaris ncim2813 by two fold dilution method. compound 6e exhibits reasonably good activity a ...201020580853
the use of lytic bacteriophages in the prevention and eradication of biofilms of proteus mirabilis and escherichia coli.antibiotics have been the cornerstone of the clinical management of bacterial infections since their discovery in the early part of the last century. eight decades later, their widespread, often indiscriminate use, has resulted in an overall reduction in their effectiveness, with reports of multidrug-resistant bacteria now commonplace. increasing reliance on indwelling medical devices, which are inherently susceptible to biofilm-mediated infections, has contributed to unacceptably high rates of ...201020528927
phylogenetic analysis of the genera proteus, morganella and providencia by comparison of rpob sequences of type and clinical strains suggests the classification of proteus myxofaciens in a new genus cosenzaea gen. nov., as cosenzaea myxofaciens comb. nov.phylogenetic analysis of partial rpob gene sequences of type and clinical strains belonging to different 16s rrna gene-fingerprinting ribogroups within 11 species of enterobacteria of the genera proteus, morganella, and providencia allowed to define rpob clades supported by high bootstrap values and confirmed by >/=2.5% nucleotide divergence. no rpob clade included strains belonging to different species and the majority of the species were confirmed as discrete and homogeneous, since they consti ...201020709916
seasonal variation, chemical composition, and analgesic and antimicrobial activities of the essential oil from leaves of tetradenia riparia (hochst.) codd in southern brazil.the seasonal variation of the chemical composition of the essential oil from fresh leaves of tetradenia riparia (hochst.) codd grown in southern brazil was analyzed by gc-ms, and the analgesic and antimicrobial activities of this oil were assayed. the yield of essential oil ranged from 0.17% to 0.26%, with the maximum amount in winter and the minimum in spring. the results obtained from principal components analysis (pca) revealed the existence of high chemical variability in the different seaso ...201020714310
high prevalence and molecular characterization of extended-spectrum β-lactamase-producing proteus mirabilis strains in southern croatia.the aim of this study was to determine the prevalence and antibiotic resistance rates of extended-spectrum β-lactamase (esbl)-producing proteus mirabilis strains isolated from inpatients at the split university hospital (southern croatia) during a survey performed between 2005 and 2008. a total of 2152 consecutive isolates of p. mirabilis were isolated. the prevalence was 0.5 % in 2005 and increased significantly to 20.9 % by 2008. strains were most frequently isolated from urine (36.5 %) and br ...201020558587
efficacy and safety of moxifloxacin in uncomplicated pelvic inflammatory disease: the monalisa study.to evaluate the efficacy and safety of moxifloxacin versus levofloxacin plus metronidazole in uncomplicated pelvic inflammatory disease (upid) in asia.201020716255
a genome-wide analysis of loss of heterozygosity and chromosomal copy number variation in proteus syndrome using high-density snp microarrays.excessive cell proliferation and genetic changes such as loss of an allele (loss of heterozygosity (loh)) or amplifications or deletions of parts of chromosomes (copy number variations (cnv)) are common findings in cancers. it is unknown whether these changes are also present in patients with overgrowth syndromes, although the presence of small-scale cnvs (such as duplication of 11p15 in beckwith-wiedemann syndrome), excessive cell proliferation and an increased frequency of tumors have all been ...201020555334
[analysis of drug resistance and risk factors of enterobacteriaceae in burn units].to study the risk factors of infection of extended-spectrum beta-lactamases (esbl)-producing strains and drug resistance of enterobacteriaceae that infected burn patients.201020723421
molecular and genetic analyses of the putative proteus o antigen gene locus.proteus species are well-characterized opportunistic pathogens primarily associated with urinary tract infections (uti) of humans. the proteus o antigen is one of the most variable constituents of the cell surface, and o antigen heterogeneity is used for serological classification of proteus isolates. even though most proteus o antigen structures have been identified, the o antigen locus has not been well characterized. in this study, we identified the putative proteus o antigen locus and demons ...201020581173
[nosocomial infections at clinical centre in kragujevac--prevalence study].nosocomial infections (nis) are a serious health problem in hospitals worldwide and are followed by a series of consequences, medical, judicial, ethical and economic.201020607980
[outbreak of diarrhea by rotavirus in bom jesus city, piauí state].this study focused a diarrhea outbreak caused by rotavirus in a city of piauí state aiming to identify the etiology, protocol of assistance to cases. a case series was carried out with 22 children assisted for acute diarrhea in 2006 in health units of bom jesus city. the data were collected by means of interviews utilizing forms that were with the help of the children's parents and analysis of the appointment files was performed. most of the families (59.1%) had a monthly income inferior to the ...201020640260
antibiotic susceptibility of urogenital microbial profile of infertile men in south-eastern nigeria.male factors are known to contribute significantly to the infertility problem. the urogenital bacteria profile and semen quality were investigated among 160 men attending infertility clinics in south-eastern nigeria. both semen and urine samples were obtained from each subject and analysed according to standard techniques. a total of 16 (10%) had bacterial infection in their semen samples and individuals of older age groups were significantly affected (chi(2) = 23.18, p < 0.05). urinary tract in ...201020629651
spread of odontogenic infections in port harcourt, nigeria.odontogenic infections constitute a substantial portion of diseases encountered by oral and maxillofacial surgeons. infections start from dental tissues and sometimes rapidly spread to contiguous spaces. the consequence is a fulminant disease with significant morbidity and mortality. the study was aimed at studying the pattern of spread, approach to management, and outcome of these infections at a nigerian teaching hospital.201020633973
suprathel-acetic acid matrix versus acticoat and aquacel as an antiseptic dressing: an in vitro study.the treatment of burn wounds is still a challenge regarding the management of antiseptic wound conditioning. especially, in the united states, silver-containing dressings, such as acticoat and aquacel are frequently used. because silver-containing dressings have well-known drawbacks such as an antimicrobial lack against pseudomonas aeruginosa, we sought to develop an alternative dressing method. in previous studies, we could demonstrate the excellent antiseptic properties of acetic acid against ...201020798627
[immunovac-vp4 vaccine used in complex allergen-specific immunotherapy of patients with hay fever].assessment of clinical and immunological effects of use of bacterial therapeutic polycomponent vaccine immunovac-vp4 for allergen-specific immunotherapy (asit) of hay fever.201020799399
host-pathogen interactions in urinary tract infection.the urinary tract is a common site of bacterial infections; nearly half of all women experience at least one urinary tract infection (uti) during their lifetime. these infections are classified based on the condition of the host. uncomplicated infections affect otherwise healthy individuals and are most commonly caused by uropathogenic escherichia coli, whereas complicated infections affect patients with underlying difficulties, such as a urinary tract abnormality or catheterization, and are com ...201020647992
characterization of the hydrophobic substrate-binding site of the bacterial beta class glutathione transferase from proteus mirabilis.since their discovery, bacterial glutathione (gsh)transferases have been characterized in terms of their ability to catalyse a variety of different reactions on a large set of toxic molecules of xenobiotic or endobiotic origin. furthermore the contribution of different residues in the gsh-binding site to gsh activation has been extensively investigated. little is known, however, about the contribution to catalysis and overall stability of single residues shaping the hydrophobic co-substrate bind ...201020663851
discorhabdins from the korean marine sponge sceptrella sp.two new pyrroloiminoquinone alkaloids of the discorhabdin class, along with 12 compounds including one previously described synthetic derivative of the same and related skeletal classes, were isolated from the sponge sceptrella sp., collected from gageodo, korea. the structures of these new compounds, designated as (-)-3-dihydrodiscorhabdin d (11) and (-)-discorhabdin z (12), were determined by combined spectroscopic analyses. compound 12 possesses an unusual hemiaminal group among the discorhab ...201020055495
orbus hercynius gen. nov., sp. nov., isolated from faeces of wild boar, is most closely related to members of the orders 'enterobacteriales' and pasteurellales.a novel gammaproteobacterium, strain cn3(t), was isolated from the faeces of wild boar. strain cn3(t) was facultatively anaerobic and appeared coccoid or rod-shaped. the partial 16s rrna gene sequence determined for strain cn3(t) suggested a distant relationship with members of the orders 'enterobacteriales' and pasteurellales. the gene sequence showed highest similarity (90.3 %) with obesumbacterium proteus dsm 2777(t), a member of the family enterobacteriaceae. the closest relatives outside th ...201020023064
distinct bacterial colonization patterns of escherichia coli subtypes associate with rheumatoid factor status in early inflammatory arthritis.the aetiology of ra is unknown; however, bacterial exposure, particularly to escherichia coli, proteus mirabilis and klebsiella pneumoniae, has been linked to disease pathogenesis. the strongest association was observed for rf(+) ra. we compare colonization patterns of these bacteria, and the anti-bacterial antibody levels in early onset rf(+) and rf(-) inflammatory arthritis.201020360042
transfer of a phage t4 gene into enterobacteriaceae, determined at the single-cell level.the transfer range of phage genes was investigated at the single-cell level by using an in situ dna amplification technique. after absorption of phages, a phage t4 gene was maintained in the genomes of non-plaque-forming bacteria at frequencies of 10(-2) gene copies per cell. the gene transfer decreased the mutation frequencies in nonhost recipients.201020023087
proteus mirabilis sp. intestinal microflora grow in a dextran sulfate sodium-rich environment.the pathogenic mechanisms responsible for inflammatory bowel disease, especially ulcerative colitis (uc), are poorly understood. as an animal model, the oral administration of dextran sulfate sodium (dss) induces colitis, which exhibits several clinical and histological features similar to uc. however, the pathogenic factors responsible for dss-induced colitis and above all, the intestinal microflora in this colitis remain unclear. therefore, we investigated the relationships between dss and the ...201020043128
bladder hemangiomas and proteus syndrome: a rare clinical association.a case of bladder hemangiomas in association with proteus syndrome (ps) is described. ps is a rare hamartomatous disorder and comprises an association of verrucous epidermal nevi, infantile hemangiomas, lipoma-like subcutaneous hamartomas and asymmetrical overgrowth of almost any part of the body. to our knowledge, this is the second case reported of hematuria associated with bladder hemangiomas in ps.201020044313
species differentiation of seafood spoilage and pathogenic gram-negative bacteria by maldi-tof mass fingerprinting.species differentiation is important for the early detection and identification of pathogenic and food-spoilage microorganisms that may be present in fish and seafood products. the main 26 species of seafood spoilage and pathogenic gram-negative bacteria, including aeromonas hydrophila, acinetobacter baumanii, pseudomonas spp., and enterobacter spp. among others, were characterized by matrix-assisted laser desorption ionization-time of flight mass spectrometry (maldi-tof ms) of low molecular wei ...201020408567
pathogenicity of aeromonas hydrophila, klebsiella pneumoniae, and proteus mirabilis to brown tree frogs (litoria ewingii).bacterial dermatosepticemia, a systemic infectious bacterial disease of frogs, can be caused by several opportunistic gram-negative bacterial species including aeromonas hydrophila, chryseobacterium indologenes, chryseobacterium meningosepticum, citrobacter freundii, klebsiella pneumoniae, proteus mirabilis, pseudomonas aeruginosa, and serratia liquifaciens. here we determined the pathogenicity of 3 bacterial species (aeromonas hydrophila, klebsiella pneumoniae, and proteus mirabilis) associated ...201020412685
recovery and screening for antibiotic susceptibility of potential bacterial pathogens from the oral cavity of shark species involved in attacks on humans in recife, brazil.the number of incidents involving sharks and humans at beaches in recife, on the north-eastern brazilian coast, is among the highest worldwide. in addition, wound infections in survivors are common; but the nature and risk of the aetiological agents is unknown. in the present study, 81 potential bacterial pathogens were identified in the oral cavity of sharks involved in attacks in recife, and were subjected to antibiotic susceptibility tests using the standardized disc-diffusion method. the maj ...201020413619
the effect of ph and chemical preservatives on the growth of bacterial isolates from some nigerian packaged fruit juices.bacterial pathogens were isolated from some nigerian packaged fruit juices. the isolates were characterized and identified as bacillus licheniformis, aeromonas hydrophila, bacillus circulans, proteus morganii, pseudomonas cepacia, bacillus alvei and pseudomonas chlororaphis. the antibiotic susceptibility profile of the seven isolates was determined and it was discovered that 65% of the microorganisms isolated were resistance to the antibiotic used while 35% were sensitive. the effect of ph, benz ...201020415148
[characteristics of urinary tract infections in different patient subpopulations and depending on the bladder emptying system].to analyze the prevalence and etiology of urinary tract infection in patients with neurogenic bladder depending on the bladder emptying system used as compared to a population with no neurological impairment. to assess perception of urinary tract infection by patients with neurogenic bladder.201020416242
ureases as a target for the treatment of gastric and urinary infections.urease is known to be a major contributor to pathologies induced by helicobacter pylori and proteus species. in h pylori, urease allows the bacteria to survive in an acidic gastric environment during colonisation, playing an important role in the pathogenesis of gastric and peptic ulcers. ureolytic activity also results in the production of ammonia in close proximity to the gastric epithelium, causing cell damage and inflammation. in the case of proteus species (notably proteus mirabilis) infect ...201020418234
bacteriological study of aerobic isolates from plantar ulcers of paucibacillary leprosy patients.plantar ulcers commonly occur in leprosy patients, which usually recur and cause morbidity in such cases.201020418976
assessing the emergence of resistance: the absence of biological cost in vivo may compromise fosfomycin treatments for p. aeruginosa infections.fosfomycin is a cell wall inhibitor used efficiently to treat uncomplicated urinary tract and gastrointestinal infections. a very convenient feature of fosfomycin, among others, is that although the expected frequency of resistant mutants is high, the biological cost associated with mutation impedes an effective growth rate, and bacteria cannot offset the obstacles posed by host defenses or compete with sensitive bacteria. due to the current scarcity of new antibiotics, fosfomycin has been propo ...201020419114
antibiotic resistance in community-acquired urinary tract infections: prevalence and risk factors.this study aimed to identify the agents causing community-acquired urinary tract infections (cautis) and their resistance patterns and to investigate risk factors for esbl production.201020424552
severe renal failure in acute bacterial pyelonephritis: do not forget corticosteroids.acute renal failure (arf) is a rare complication of acute pyelonephritis in adult immunocompetent patients. recovery of renal function usually occurs if antibiotics are promptly initiated. however, long-term consequences of renal scarring due to acute pyelonephritis are probably underestimated, and some patients present with prolonged renal failure despite adequate antibiotic therapy. we report two cases of severe arf complicating bacterial pyelonephritis successfully treated with corticosteroid ...201020061705
from congenital dermal sinus tract to extensive epidural abscess of the spine. 201020301052
an assessment of the antibacterial activity in larval excretion/secretion of four species of insects recorded in association with corpses, using lucilia sericata meigen as the marker species.the relative antibacterial activities of excretion/secretion (es) from two carrion-feeding insects, calliphora vicina robineau-desvoidy and dermestes maculatus degeer, and a detritivore, tenebrio molitor linnaeus, were compared to that of lucilia sericata meigen, a species with es of known antibacterial capacity, in order to explore the antimicrobial potential of other carrion and detritivore species. viable counts were used to assess time-kill of es against five bacterial species, staphylococcu ...201020307342
structural and serological studies of the o-polysaccharide of strains from a newly created proteus o78 serogroup prevalent in polish patients.seven proteus mirabilis strains from five polish patients (five isolates from urea and two from feces) appeared to be a bacterial clone widespread in hospitals, most probably due to nosocomial infection and autoinfection. enzyme-linked immunosorbent assay and western blot showed that lipopolysaccharides from all strains studied are serologically identical to each other but distinct from proteus lipopolysaccharides studied earlier and, hence, these strains could not be classified in any of the cu ...201020002745
bacterial colonization of chronic leg ulcers: current results compared with data 5 years ago in a specialized dermatology department.in nearly every chronic wound different bacteria species can be detected. nevertheless, the presence of such microorganisms is not necessarily obligatory associated with a delayed wound healing. but from this initially unproblematic colonization an infection up to a sepsis can arise in some patients. the aim of our clinical investigation was to analyse the spectrum of microbial colonization of patients with a chronic leg ulcer in our specialized dermatological outpatient wound clinic, and to com ...201020236200
modification of n-glycosylation sites allows secretion of bacterial chondroitinase abc from mammalian cells.although many eukaryotic proteins have been secreted by transfected bacterial cells, little is known about how a bacterial protein is treated as it passes through the secretory pathway when expressed in a eukaryotic cell. the eukaryotic n-glycosylation system could interfere with folding and secretion of prokaryotic proteins whose sequence has not been adapted for glycosylation in structurally appropriate locations. here we show that such interference does indeed occur for chondroitinase abc fro ...201019900493
proteus mirabilis pmri, an rppa-regulated gene necessary for polymyxin b resistance, biofilm formation, and urothelial cell invasion.proteus mirabilis is naturally resistant to polymyxin b (pb). to investigate the underlying mechanisms, tn5 mutagenesis was performed, and a mutant exhibiting increased pb susceptibility was isolated. the mutant was found to have tn5 inserted into the ppmri (proteus pmri) gene, a gene which may encode a udp-glucuronic acid decarboxylase. in other bacteria, pmri belongs to the seven-gene pmrf operon, which is involved in lipopolysaccharide (lps) modification. while the ppmri knockout mutant had a ...201020123999
differences in biofilm formation and aggregative adherence between beta-lactam susceptible and beta-lactamases producing p. mirabilis clinical isolates.biofilm formation of multidrug resistant (mdr) extended-spectrum beta-lactamase (esbetal) producing proteus mirabilis isolates from a long-term care and rehabilitation facility (ltcrf) in northern italy was evaluated. a total of 10 strains, 4/10 producing the acquired ampc beta-lactamase cmy-16, 3/10 producing the esbetal tem-92 and the remaining negative for the presence of beta-lactamase genes, were studied using standard adherence assays on titer plates. tests were performed in three differen ...201020402412
introducing the scanning air puff tonometer for biological studies.it is getting increasingly evident that physical properties such as elastoviscoplastic properties of living materials are quite important for the process of tissue development, including regulation of genetic pathways. measuring such properties in vivo is a complicated and challenging task. in this paper, we present an instrument, a scanning air puff tonometer, which is able to map point by point the viscoelastic properties of flat or gently curved soft materials. this instrument is an improved ...201020365608
antimicrobial susceptibility of gram-negative nonurinary bacteria to fosfomycin and other antimicrobials.fosfomycin is an antimicrobial commonly used in uncomplicated urinary tract infections. the microbiological effectiveness of fosfomycin against nonurinary gram-negative isolates has not been widely investigated. the aim of this study was to evaluate the in vitro activity of fosfomycin against gram-negative nonurinary isolates in a region of greece where considerable antimicrobial resistance has been detected.201020521939
synthesis, nematicidal and antimicrobial activity of 3-(5-3-methyl-5-[(3-methyl-7-5-[2-(aryl)-4-oxo-1,3-thiazolan-3-yl]-1,3,4-thiadiazol-2-ylbenzo[b]furan-5-yl)methyl]benzo[b]furan-7-yl-1,3,4-thiadiazol-2-yl)-2-(aryl)-1,3-thiazolan-4-one.a new series of 3-(5-3-methyl-5-[(3-methyl-7-5-[2-(aryl)-4-oxo-1,3-thiazolan-3-yl]-1,3,4-thiadiazol-2-ylbenzo[b]furan-5-yl)methyl]benzo[b]furan-7-yl-1,3,4-thiadiazol-2-yl)-2-(aryl)-1,3-thiazolan-4-one 5a-j has been synthesized by the reaction of n2-[(e)-1-(4-methylphenyl)methylidene]-5-(3-methyl-5-[3-methyl-7-(5-[(e)-1-(4-methylphenyl)methylidene]amino-1,3,4-thiadiazol-2-yl)benzo[b]furan-5-yl]methylbenzo[b]furan-7-yl)-1,3,4-thiadiazol-2-amine 4a-j with thioglycolic acid. chemical structures of a ...201020522990
[urinary tract infections caused by extended-spectrum beta-lactamase (esbl)--producing enterobacteria in outpatients from primorsko-goranska county, croatia].the aim of this study was to report the prevalence of uropathogens and the frequency of extended spectrum beta-lactamases (esbl) producing strains isolated from urine of outpatients in primorsko-goranska county in croatia. we have retrospectively analyzed the results of 44, 321 urine cultures from january 01, 2008 till june 30, 2009. the study showed that esbl production was confirmed in 189 (1.8%) of the total of 10,757 isolates. rates of esbl-producing isolates were 19%, 0,6%, and 5.2% for kle ...201020387729
synthesis and antibacterial activity of carvacryl ethers.structural modifications of phenolic monoterpenoid obtained by reacting carvacrol with various substituted alpha-chloro acetanilides, to improve biological activities which give the product with better yield and higher purity under mild reaction conditions with the help of microwave irradiation techniques.201020390755
antimicrobial susceptibility patterns of community-acquired uropathogens in tehran, iran.antibiotic resistance of urinary tract pathogens has increased worldwide. knowledge of the antibiotic resistance patterns of uropathogens in specific geographical locations is an important factor for choosing an appropriate empirical antimicrobial treatment. the aim of this study was to provide information regarding local resistance patterns of urinary pathogens to the commonly used antibiotics in tehran, iran.201020440056
resistance to ciprofloxacin by enhancement of antioxidant defenses in biofilm and planktonic proteus mirabilis.antibiotic resistance and antioxidant defense were induced by ciprofloxacin in planktonic proteus mirabilis and compared with the natural antibiotic resistance of biofilm. resistant variants (1x and 1y) were obtained from cultures of the sensitive wild type "wt" strain 1 in the presence of the antibiotic. planktonic strain 1 exhibited oxidative stress with increases in the reactive oxygen species (ros) and consumption of no in the presence of ciprofloxacin, whereas 1x and 1y suffered non-signifi ...201020097163
acute pyelonephritis can have serious complications.urinary tract infection (uti) may predominantly involve the lower urinary tract, i.e. acute cystitis, or upper urinary tract consisting of the renal pelvis and kidney,, i.e. acute pyelonephritis the incidence of acute pyelonephritis is higher in young women than in men but the incidence in men over 65 is similar to that in older women. women have up to a 10% risk of recurrent acute pyelonephritis in the year following a first acute episode. the equivalent risk in men is 6%. acute pyelonephritis ...201020486480
assessment upon azo dye decolorization and bioelectricity generation by proteus hauseri.this study explored dye decolorization and bioelectricity generation of indigenous proteus hauseri zmd44 for dye-bearing wastewater treatment. chemical structures of azo dyes apparently affected the performance of dye biodecolorization. additions of diazo dye c.i. reactive blue 160 (rbu160) stimulated simultaneous dye decolorization and bioelectricity generation of zmd44 in single chamber microbial fuel cells (mfcs). however, high-level additions of rbu160 repressed capabilities of power product ...201020156682
ultrastructure of previtellogene oocytes in the neotenic cave salamander proteus anguinus anguinus (amphibia, urodela, proteidae).oogenesis in the neotenic, cave dwelling salamander proteus anguinus anguinus has not been studied yet, and this study provides a detailed description of the early growth of the oocytes. early previtellogene oocytes ranging from 100 to 600 µm in diameter were examined by light and transmission electron microscopy. the oocytes were divided into two stages based on size, color, and histology. stage i oocytes can be identified by their transparent cytoplasm and a homogenous juxtanuclear mass, compo ...201020177720
volatiles emitted from eight wound-isolated bacteria differentially attract gravid screwworms (diptera: calliphoridae) to oviposit.bovine blood inoculated with bacteria isolated from screwworm [cochliomyia hominivorax (coquerel) (diptera: calliphoridae)]-infested animal wounds was tested as an attractant for oviposition for gravid screwworms. eight species of gram-negative coliform (enterobacteriaceae) bacteria mixed with bovine blood singly or all species combined and incubated for various times produced volatiles that attracted gravid flies in a cage bioassay in varying numbers. in 15-min duration tests, volatiles from fi ...201020496582
regulation of gene expression during swarmer cell differentiation in proteus mirabilis.the gram-negative bacterium proteus mirabilis can exist in either of two cell types, a vegetative cell characterized as a short rod and a highly elongated and hyperflagellated swarmer cell. this differentiation is triggered by growth on solid surfaces and multiple inputs are sensed by the cell to initiate the differentiation process. these include the inhibition of flagellar rotation, the accumulation of extracellular putrescine and o-antigen interactions with a surface. a key event in the diffe ...201020497230
pulmonary manifestations and management of proteus syndrome.proteus syndrome is a very rare, sporadic and congenital condition that is characterized by postnatal mosaic overgrowth. this disorder is thought to be caused by a somatic gene mutation, but the exact etiology is unknown. commonly involved tissues include connective tissue, bone, skin and the central nervous system. another less common symptom involves pulmonary emphysematous changes. this report documents a 25-year-old man with proteus syndrome who presented with progressive exertional dyspnea ...201020497874
dextran sulfate sodium and 2,4,6-trinitrobenzene sulfonic acid induce lipid peroxidation by the proliferation of intestinal gram-negative bacteria in mice.abstrect:201020181058
cultural sensitivity removes barriers to better care. a letter to the editor on article "parental preference or child well-being: an ethical dilemma". 201020185056
management of craniofacial hyperostosis in proteus syndrome.proteus syndrome is a rare congenital hamartomatous condition that is characterized by a wide range of malformations, occasionally involving the head and the face. skin and skeletal developmental malformations are common and may be manifested in significant physical anomalies. in this report, we describe the cases of 2 patients affected by this condition. for one patient, a recurrence occurred 4 years after the elimination of cranial hyperostosis. in the second patient, although we observed macr ...201020216456
effectiveness and safety of colistin: prospective comparative cohort study.colistin has re-entered clinical use by necessity. we aimed to assess its effectiveness and safety compared with newer antibiotics.201020299494
prevalence of proteus mirabilis in skin abscesses of the axilla.gram-positive organisms are the most common infectious etiologic agents in skin abscesses. empiric antimicrobial treatment choices are influenced by this knowledge. in this report, we describe a high prevalence of proteus mirabilis, a gram-negative bacillus, in skin abscesses of the axilla, which has potential implications for selection of antimicrobial therapy.201020303504
communal action of microbial cultures for red he3b degradation.the consortium pmb11 consisting of three bacterial species, originally isolated from dye contaminated soil was identified as bacillus odysseyi suk3, morganella morganii suk5 and proteus sp. suk7. the consortium possessed the ability to decolorize various textile dyes as well as mixtures of dyes. pmb11 could decolorize red he3b (50 mg l(-1)) with 99% of decolorization within 12 h in nutrient broth, while in mineral medium it could decolorize up to 97% within 24h. induction in the activities of va ...201020510505
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