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syndromes with focal overgrowth in infancy: diagnostic approach and surgical treatment.abstract syndromes with focal overgrowth are sporadic diseases and comprise proteus syndrome and congenital lipomatous overgrowth, vascular malformations, and epidermal naevi (clove) syndrome, and isolated hemihyperplasia. we describe 3 children classified according to standard criteria with dysregulated growth of various tissues that was excised, together with excess toes, and tumours. correct classification facilitates diagnosis and operations. interdisciplinary treatment and follow-up are rec ...201019634071
characterization and flocculation mechanism of high efficiency microbial flocculant tj-f1 from proteus mirabilis.the characterization and the flocculation mechanism of microbial flocculant tj-f1 with high flocculating activity, produced by proteus mirabilis from a mixed activated sludge, was investigated. mainly consisting of protein and acid polysaccharide, tj-f1 owns a molecular weight of 1.2 x 10(5)da, which brings strong van der waals forces and ample binding-sites. it contains carboxyl, hydroxyl, amino groups and hydrogen bonds preferred for the flocculation process. the key parameters influencing the ...201019773148
from proteus to prometheus: learning from fish to modulate regeneration. 201020378822
loss of the waal o-antigen ligase prevents surface activation of the flagellar gene cascade in proteus mirabilis.proteus mirabilis is a gram-negative bacterium that undergoes a physical and biochemical change from a vegetative swimmer cell (a typical gram-negative rod) to an elongated swarmer cell when grown on a solid surface. in this study, we report that a transposon insertion in the waal gene, encoding o-antigen ligase, blocked swarming motility on solid surfaces but had little effect on swimming motility in soft agar. the waal mutant was unable to differentiate into a swarmer cell. differentiation was ...201020382766
zinc uptake contributes to motility and provides a competitive advantage to proteus mirabilis during experimental urinary tract infection.proteus mirabilis, a gram-negative bacterium, represents a common cause of complicated urinary tract infections in catheterized patients or those with functional or anatomical abnormalities of the urinary tract. znub, the membrane component of the high-affinity zinc (zn(2+)) transport system znuacb, was previously shown to be recognized by sera from infected mice. since this system has been shown to contribute to virulence in other pathogens, its role in proteus mirabilis was investigated by con ...201020385754
[urinary tract infections caused by extended-spectrum beta-lactamase (esbl)--producing enterobacteria in outpatients from primorsko-goranska county, croatia].the aim of this study was to report the prevalence of uropathogens and the frequency of extended spectrum beta-lactamases (esbl) producing strains isolated from urine of outpatients in primorsko-goranska county in croatia. we have retrospectively analyzed the results of 44, 321 urine cultures from january 01, 2008 till june 30, 2009. the study showed that esbl production was confirmed in 189 (1.8%) of the total of 10,757 isolates. rates of esbl-producing isolates were 19%, 0,6%, and 5.2% for kle ...201020387729
synthesis and antibacterial activity of carvacryl ethers.structural modifications of phenolic monoterpenoid obtained by reacting carvacrol with various substituted alpha-chloro acetanilides, to improve biological activities which give the product with better yield and higher purity under mild reaction conditions with the help of microwave irradiation techniques.201020390755
introducing the scanning air puff tonometer for biological studies.it is getting increasingly evident that physical properties such as elastoviscoplastic properties of living materials are quite important for the process of tissue development, including regulation of genetic pathways. measuring such properties in vivo is a complicated and challenging task. in this paper, we present an instrument, a scanning air puff tonometer, which is able to map point by point the viscoelastic properties of flat or gently curved soft materials. this instrument is an improved ...201020365608
transcriptome of swarming proteus mirabilis.swarming motility by the urinary tract pathogen proteus mirabilis has been a long-studied but little understood phenomenon. on agar, a p. mirabilis colony grows outward in a bull's-eye pattern formed by consecutive waves of rapid swarming followed by consolidation into shorter cells. to examine differential gene expression in these growth phases, a microarray was constructed based on the completed genome sequence and annotation. rna was extracted from broth-cultured, swarming, and consolidation- ...201020368347
the encrustation and blockage of long-term indwelling bladder catheters: a way forward in prevention and control.to review the literature showing that understanding how foley catheters become encrusted and blocked by crystalline bacterial biofilms has led to strategies for the control of this complication in the care of patients undergoing long-term indwelling bladder catheterization.201020368711
from congenital dermal sinus tract to extensive epidural abscess of the spine. 201020301052
prevalence of proteus mirabilis in skin abscesses of the axilla.gram-positive organisms are the most common infectious etiologic agents in skin abscesses. empiric antimicrobial treatment choices are influenced by this knowledge. in this report, we describe a high prevalence of proteus mirabilis, a gram-negative bacillus, in skin abscesses of the axilla, which has potential implications for selection of antimicrobial therapy.201020303504
proteus in the world of proteins: conformational changes in protein kinases.the 512 protein kinases encoded by the human genome are a prime example of nature's ability to create diversity by introducing variations to a highly conserved theme. the activity of each kinase domain is controlled by layers of regulatory mechanisms involving different combinations of post-translational modifications, intramolecular contacts, and intermolecular interactions. ultimately, they all achieve their effect by favoring particular conformations that promote or prevent the kinase domain ...201020336692
an assessment of the antibacterial activity in larval excretion/secretion of four species of insects recorded in association with corpses, using lucilia sericata meigen as the marker species.the relative antibacterial activities of excretion/secretion (es) from two carrion-feeding insects, calliphora vicina robineau-desvoidy and dermestes maculatus degeer, and a detritivore, tenebrio molitor linnaeus, were compared to that of lucilia sericata meigen, a species with es of known antibacterial capacity, in order to explore the antimicrobial potential of other carrion and detritivore species. viable counts were used to assess time-kill of es against five bacterial species, staphylococcu ...201020307342
triblock copolymer matrix-based capillary electrophoretic microdevice for high-resolution multiplex pathogen detection.rapid and simple analysis for the multiple target pathogens is critical for patient management. ce-sscp analysis on a microchip provides high speed, high sensitivity, and a portable genetic analysis platform in molecular diagnostic fields. the capability of separating ssdna molecules in a capillary electrophoretic microchannel with high resolution is a critical issue to perform the precise interpretation in the electropherogram. in this study, we explored the potential of poly(ethyleneoxide)-pol ...201020309929
bacterial colonization of chronic leg ulcers: current results compared with data 5 years ago in a specialized dermatology department.in nearly every chronic wound different bacteria species can be detected. nevertheless, the presence of such microorganisms is not necessarily obligatory associated with a delayed wound healing. but from this initially unproblematic colonization an infection up to a sepsis can arise in some patients. the aim of our clinical investigation was to analyse the spectrum of microbial colonization of patients with a chronic leg ulcer in our specialized dermatological outpatient wound clinic, and to com ...201020236200
effectiveness and safety of colistin: prospective comparative cohort study.colistin has re-entered clinical use by necessity. we aimed to assess its effectiveness and safety compared with newer antibiotics.201020299494
worldwide experience with the use of doripenem against extended-spectrum-beta-lactamase-producing and ciprofloxacin-resistant enterobacteriaceae: analysis of six phase 3 clinical studies.the worldwide increase in fluoroquinolone-resistant and extended-spectrum beta-lactamase (esbl)-producing enterobacteriaceae pathogens has led to doripenem and other carbapenems assuming a greater role in the treatment of serious infections. we analyzed data from 6 phase 3 multinational doripenem clinical trials on ciprofloxacin-resistant enterobacteriaceae isolates consisting of all genera (cipre) and esbl-producing enterobacteriaceae isolates consisting of escherichia coli, klebsiella spp., an ...201020211892
management of chronic gangrenous mastitis in a 3-year-old cow using partial (quarter) mastectomy.bovine gangrenous mastitis is an acute or peracute condition involving one or more quarters of the cow's udder. it occurs infrequently, but when it occurs, mortality of the affected cows is high. a partial mastectomy of one quarter using a cranial epidural analgesia with 2% lignocaine is described to manage a gangrenous mastitis affecting only one quarter caused by proteus mirabilis (a gram-negative bacteria) which was not amenable to medical treatment. partial mastectomy can be a safe and effec ...201020213222
photoantimicrobials as a potential local approach to geriatric utis.to test the efficacy of acceptable photoantimicrobial agents against bacterial pathogens implicated in complicated urinary tract infection (uti) in comparison with conventionally employed antibacterials.201020214732
management of craniofacial hyperostosis in proteus syndrome.proteus syndrome is a rare congenital hamartomatous condition that is characterized by a wide range of malformations, occasionally involving the head and the face. skin and skeletal developmental malformations are common and may be manifested in significant physical anomalies. in this report, we describe the cases of 2 patients affected by this condition. for one patient, a recurrence occurred 4 years after the elimination of cranial hyperostosis. in the second patient, although we observed macr ...201020216456
antibacterial and antifungal properties of acetonic extract of feijoa sellowiana fruits and its effect on helicobacter pylori growth.feijoa sellowiana berg. fruit, widely used for human consumption, is well appreciated for its good nutritional characteristics and for its pleasant flavor and aroma. in a prior study we showed that the acetonic extract of f. sellowiana fruit exerts a potent antibacterial activity against some gram-positive and gram-negative bacterial strains. to confirm and deepen the study on antimicrobial activities of the fruit, in this article we analyze the same extract for its effectiveness against differe ...201020136454
autoimmune diseases: solution of the environmental, immunological and genetic components with principles for immunotherapy and transplantation.autoimmune diseases have environmental and genetic components. these are the microbial trigger, the immunity system component and the genetic component. here we describe these components and how they interact. known microbial triggers are streptococcus pyogenes for rheumatic carditis, proteus mirabilis for rheumatoid arthritis and klebsiella pneumoniae for ankylosing spondylitis. the immunity system component has been clarified by realisation that no autoimmune disease is caused by loss of suppr ...201020083235
parental preference or child well-being: an ethical dilemma.an ethical dilemma that is not uncommon to encounter when caring for children occurs when parental preference does not appear to be in the child's best interest. challenges facing the health care team are further amplified when the family's cultural background does not match that of the team. a case study will be used to illustrate the challenges of a pediatric palliative care ethical dilemma further complicated by cultural diversity. review of the child's medical condition, patient/parent prefe ...201020117678
extended-spectrum beta-lactamase-producing escherichia coli in patients with travellers' diarrhoea.the identification of patients carrying extended-spectrum beta-lactamase (esbl)-producing bacteria is important, since these patients are at risk of receiving inappropriate empirical therapy if they become infected. the purpose of this study was to investigate the occurrence of esbl-producing bacteria in patients with travellers' diarrhoea. patients with travellers' diarrhoea (n = 242) having delivered stool samples for the diagnosis of salmonella, shigella, yersinia or campylobacter, were also ...201020121649
proteus mirabilis pmri, an rppa-regulated gene necessary for polymyxin b resistance, biofilm formation, and urothelial cell invasion.proteus mirabilis is naturally resistant to polymyxin b (pb). to investigate the underlying mechanisms, tn5 mutagenesis was performed, and a mutant exhibiting increased pb susceptibility was isolated. the mutant was found to have tn5 inserted into the ppmri (proteus pmri) gene, a gene which may encode a udp-glucuronic acid decarboxylase. in other bacteria, pmri belongs to the seven-gene pmrf operon, which is involved in lipopolysaccharide (lps) modification. while the ppmri knockout mutant had a ...201020123999
extension of an infectious abdominal aneurysm into the l3 and l4 vertebrae: report of a difficult case. 201020149710
differential characterization of biogenic amine-producing bacteria involved in food poisoning using maldi-tof mass fingerprinting.histamine poisoning is caused by the consumption of fish and other foods that harbor bacteria possessing histidine decarboxylase activity. with the aim of preventing histamine formation, highly specific mass spectral fingerprints were obtained from the 16 major biogenic amine-producing enteric and marine bacteria by means of maldi-tof ms analysis. all bacterial strains analyzed exhibited specific spectral fingerprints that enabled its unambiguous differentiation. this technique also identified p ...201020151397
assessment upon azo dye decolorization and bioelectricity generation by proteus hauseri.this study explored dye decolorization and bioelectricity generation of indigenous proteus hauseri zmd44 for dye-bearing wastewater treatment. chemical structures of azo dyes apparently affected the performance of dye biodecolorization. additions of diazo dye c.i. reactive blue 160 (rbu160) stimulated simultaneous dye decolorization and bioelectricity generation of zmd44 in single chamber microbial fuel cells (mfcs). however, high-level additions of rbu160 repressed capabilities of power product ...201020156682
characterization of udp-glucose dehydrogenase and udp-glucose pyrophosphorylase mutants of proteus mirabilis: defectiveness in polymyxin b resistance, swarming, and virulence.proteus mirabilis is known to be highly resistant to the action of polymyxin b (pb). however, the mechanism underlying pb resistance is not clear. in this study, we used tn5 transposon mutagenesis to identify genes that may affect pb resistance in p. mirabilis. two genes, ugd and galu, which may encode udp-glucose dehydrogenase (ugd) and udp-glucose pyrophosphorylase (galu), respectively, were identified. knockout mutants of ugd and galu were found to be extremely sensitive to pb, presumably bec ...201020160049
strategy to control catheter encrustation with citrated drinks: a randomized crossover study.nucleation ph is the ph at which ca and mg come out of urine to form crystals. if the safety margin between voiding ph and nucleation ph could be increased, it would increase the possibility of an alternative to controlling the activity of urease producing bacteria as a strategy to control catheter encrustation.201020171661
bladder vascular anomalies. 201020171931
synthesis, antibacterial and antifungal activities of some carbazole derivatives.a series of n-substituted carbazole derivatives were synthesized and evaluated for antibacterial and antifungal activities against staphylococcus aureus, methicillin-resistant staphylococcus aureus (mrsa), bacillus subtilis, escherichia coli, pseudomonas aeruginosa, bacillus proteus, candida albicans and aspergillus fumigatus by two fold serial dilution technique. some of the synthesized compounds displayed comparable or even better antibacterial and antifungal activities than reference drugs fl ...201020176480
ultrastructure of previtellogene oocytes in the neotenic cave salamander proteus anguinus anguinus (amphibia, urodela, proteidae).oogenesis in the neotenic, cave dwelling salamander proteus anguinus anguinus has not been studied yet, and this study provides a detailed description of the early growth of the oocytes. early previtellogene oocytes ranging from 100 to 600 µm in diameter were examined by light and transmission electron microscopy. the oocytes were divided into two stages based on size, color, and histology. stage i oocytes can be identified by their transparent cytoplasm and a homogenous juxtanuclear mass, compo ...201020177720
dextran sulfate sodium and 2,4,6-trinitrobenzene sulfonic acid induce lipid peroxidation by the proliferation of intestinal gram-negative bacteria in mice.abstrect:201020181058
cultural sensitivity removes barriers to better care. a letter to the editor on article "parental preference or child well-being: an ethical dilemma". 201020185056
lipopolysaccharide interaction is decisive for the activity of the antimicrobial peptide nk-2 against escherichia coli and proteus mirabilis.phosphatidylglycerol is a widely used mimetic to study the effects of amps (antimicrobial peptides) on the bacterial cytoplasmic membrane. however, the antibacterial activities of novel nk-2-derived amps could not be sufficiently explained by using this simple model system. since the lps (lipopolysaccharide)-containing outer membrane is the first barrier of gram-negative bacteria, in the present study we investigated interactions of nk-2 and a shortened variant with viable escherichia coli wbb01 ...201020187872
validation of the cdc biofilm reactor as a dynamic model for assessment of encrustation formation on urological device materials.contemporary medical science is reliant upon the rational selection and utilization of devices, and therefore, an increasing need has developed for in vitro systems aimed at replicating the conditions to which urological devices will be subjected to during their use in vivo. we report the development and validation of a novel continuous flow encrustation model based on the commercially available cdc biofilm reactor. proteus mirabilis-induced encrustation formation on test biomaterial sections un ...201020091909
resistance to ciprofloxacin by enhancement of antioxidant defenses in biofilm and planktonic proteus mirabilis.antibiotic resistance and antioxidant defense were induced by ciprofloxacin in planktonic proteus mirabilis and compared with the natural antibiotic resistance of biofilm. resistant variants (1x and 1y) were obtained from cultures of the sensitive wild type "wt" strain 1 in the presence of the antibiotic. planktonic strain 1 exhibited oxidative stress with increases in the reactive oxygen species (ros) and consumption of no in the presence of ciprofloxacin, whereas 1x and 1y suffered non-signifi ...201020097163
antibacterial activity of artemisia nilagirica leaf extracts against clinical and phytopathogenic bacteria.the six organic solvent extracts of artemisia nilagirica were screened for the potential antimicrobial activity against phytopathogens and clinically important standard reference bacterial strains.201020109237
in vitro antimicrobial activity of four ficus carica latex fractions against resistant human pathogens (antimicrobial activity of ficus carica latex).methanolic, hexanoïc, chloroformic and ethyl acetate extracts of ficus carica latex were investigated for their in vitro antimicrobial proprieties against five bacteria species and seven strains of fungi. the green fruit latex was collected from chott mariam souse, middle east coast of tunisia. the antimicrobial activity of the extracts was evaluated and based respectively on the inhibition zone using the disc-diffusion assay, minimal inhibition concentration (mic) for bacterial testing and the ...201020067867
antibacterial effect of nsaids on clinical isolates of urinary tract infection and diabetic foot infection.non steroidal anti-inflammatory drugs (nsaids) are a group of chemically dissimilar agents that have primary effect of inhibition of prostaglandin's synthesis. aspirin (acetyl salicylic acid) is used as an analgesic, anti pyretic, anti-inflammatory agent and also have an anticoagulant effect. tylenol (acetaminophen) is used as pain reliever. the objective of this study was to determine the effect of aspirin and tylenol against clinical isolates of urinary tract infection (uti) and diabetic foot ...201020067876
structural and serological studies of the o-polysaccharide of strains from a newly created proteus o78 serogroup prevalent in polish patients.seven proteus mirabilis strains from five polish patients (five isolates from urea and two from feces) appeared to be a bacterial clone widespread in hospitals, most probably due to nosocomial infection and autoinfection. enzyme-linked immunosorbent assay and western blot showed that lipopolysaccharides from all strains studied are serologically identical to each other but distinct from proteus lipopolysaccharides studied earlier and, hence, these strains could not be classified in any of the cu ...201020002745
detecting vim-1 production in proteus mirabilis by an imipenem-dipicolinic acid double disk synergy test. 201020007383
discorhabdins from the korean marine sponge sceptrella sp.two new pyrroloiminoquinone alkaloids of the discorhabdin class, along with 12 compounds including one previously described synthetic derivative of the same and related skeletal classes, were isolated from the sponge sceptrella sp., collected from gageodo, korea. the structures of these new compounds, designated as (-)-3-dihydrodiscorhabdin d (11) and (-)-discorhabdin z (12), were determined by combined spectroscopic analyses. compound 12 possesses an unusual hemiaminal group among the discorhab ...201020055495
necrotizing otitis externa: 19 cases' report.necrotizing otitis externa is an uncommon but severe infectious disease of the external auditory canal. patients at risk are those immunodepressed or having diabetes. the causal germ is often pseudomonas aeruginosa. over a period of 10 years (1997-2006), we treated 19 patients: 94.7% had diabetes (insulin dependent in 6 cases). the causal germ was p. aeruginosa in 59% of cases. the pretherapeutic work-up included a computed tomography and a scintigraphy practiced in order to confirm diagnosis an ...201020058154
severe renal failure in acute bacterial pyelonephritis: do not forget corticosteroids.acute renal failure (arf) is a rare complication of acute pyelonephritis in adult immunocompetent patients. recovery of renal function usually occurs if antibiotics are promptly initiated. however, long-term consequences of renal scarring due to acute pyelonephritis are probably underestimated, and some patients present with prolonged renal failure despite adequate antibiotic therapy. we report two cases of severe arf complicating bacterial pyelonephritis successfully treated with corticosteroid ...201020061705
human pathogens abundant in the bacterial metagenome of cigarettes.many studies have evaluated chemical, heavy metal, and other abiotic substances present in cigarettes and their roles in the development of lung cancer and other diseases, yet no studies have comprehensively evaluated bacterial diversity of cigarettes and the possible impacts of these microbes on respiratory illnesses in smokers and exposed nonsmokers.201020064769
proteus mirabilis sp. intestinal microflora grow in a dextran sulfate sodium-rich environment.the pathogenic mechanisms responsible for inflammatory bowel disease, especially ulcerative colitis (uc), are poorly understood. as an animal model, the oral administration of dextran sulfate sodium (dss) induces colitis, which exhibits several clinical and histological features similar to uc. however, the pathogenic factors responsible for dss-induced colitis and above all, the intestinal microflora in this colitis remain unclear. therefore, we investigated the relationships between dss and the ...201020043128
bladder hemangiomas and proteus syndrome: a rare clinical association.a case of bladder hemangiomas in association with proteus syndrome (ps) is described. ps is a rare hamartomatous disorder and comprises an association of verrucous epidermal nevi, infantile hemangiomas, lipoma-like subcutaneous hamartomas and asymmetrical overgrowth of almost any part of the body. to our knowledge, this is the second case reported of hematuria associated with bladder hemangiomas in ps.201020044313
antimicrobial resistance among clinical isolates from the chinese meropenem surveillance study (cmss), 2003-2008.the chinese meropenem surveillance study (cmss) programme was initiated in 2003 with the aim of monitoring the antimicrobial activity of broad-spectrum agents against nosocomial gram-negative bacilli in china. from 2003 to 2008, a total of 3892 isolates were collected from 10 teaching hospitals. the minimum inhibitory concentrations (mics) of 11 antimicrobial agents were determined by the agar dilution method. during the study period, a marked decrease in the susceptibility of acinetobacter spp. ...201020047820
orbus hercynius gen. nov., sp. nov., isolated from faeces of wild boar, is most closely related to members of the orders 'enterobacteriales' and pasteurellales.a novel gammaproteobacterium, strain cn3(t), was isolated from the faeces of wild boar. strain cn3(t) was facultatively anaerobic and appeared coccoid or rod-shaped. the partial 16s rrna gene sequence determined for strain cn3(t) suggested a distant relationship with members of the orders 'enterobacteriales' and pasteurellales. the gene sequence showed highest similarity (90.3 %) with obesumbacterium proteus dsm 2777(t), a member of the family enterobacteriaceae. the closest relatives outside th ...201020023064
transfer of a phage t4 gene into enterobacteriaceae, determined at the single-cell level.the transfer range of phage genes was investigated at the single-cell level by using an in situ dna amplification technique. after absorption of phages, a phage t4 gene was maintained in the genomes of non-plaque-forming bacteria at frequencies of 10(-2) gene copies per cell. the gene transfer decreased the mutation frequencies in nonhost recipients.201020023087
in vitro antimicrobial activity of a commercial ear antiseptic containing chlorhexidine and tris-edta.minimum bactericidal concentrations (mbcs) of a commercial ear antiseptic containing chlorhexidine 0.15% and tris-edta (otodine) were determined by broth microdilution for 150 isolates representing the most common pathogens associated with canine otitis. the microorganisms were classified into three groups according to their levels of susceptibility. the most susceptible group included staphylococcus pseudintermedius, malassezia pachydermatis, streptococcus canis and corynebacterium auriscanis, ...201020030799
antimicrobial susceptibility of multidrug-resistant (mdr) and extensively drug-resistant (xdr) enterobacteriaceae isolates to fosfomycin.the advancing antimicrobial drug resistance among enterobacteriaceae renders the evaluation of potential novel therapeutic options necessary. we sought to evaluate the in vitro antimicrobial activity of fosfomycin against multidrug-resistant (mdr) enterobacteriaceae isolates. antimicrobial susceptibility to fosfomycin and 12 additional antibiotics of mdr enterobacteriaceae isolates collected between november 2007 and april 2009 at the university hospital of heraklion, crete, greece, was examined ...201020034765
international spread and persistence of tem-24 is caused by the confluence of highly penetrating enterobacteriaceae clones and an inca/c2 plasmid containing tn1696::tn1 and is5075-tn21.tem-24 remains one of the most widespread tem-type extended-spectrum beta-lactamases (esbls) among enterobacteriaceae. to analyze the reasons influencing its spread and persistence, a multilevel population genetics study was carried out on 28 representative tem-24 producers from belgium, france, portugal, and spain (13 enterobacter aerogenes isolates, 6 escherichia coli isolates, 6 klebsiella pneumoniae isolates, 2 proteus mirabilis isolates, and 1 klebsiella oxytoca isolate, from 1998 to 2004). ...201019995930
urinary tract infections caused by multi-drug resistant proteus mirabilis: risk factors and clinical outcomes.proteus mirabilis (pm) as well as other members of the enterobacteriaceae family are a leading cause of infectious diseases in both the community and acute care settings. the prevalence of multi-drug resistant (mdr) bacterial isolates have increased in the last few years, affecting the prognosis and survival of hospitalized patients. the aim of our study was to determine the risk factors and clinical outcomes of urinary tract infections (utis) caused by mdr pm in patients hospitalized in our ins ...201019998053
evaluation of new chromogenic substrates for the detection of coliforms.to evaluate a new range of chromogenic substrates for the detection of beta-galactosidase activity in coliforms and to compare their performance in agar media and broths.201019878523
unilateral ovarian dermoid cyst accompanied by an ipsilateral paratubal cyst in a girl with proteus syndrome discovered by laparoscopic surgery.proteus syndrome is a rare hamartomatous disorder characterized by the overgrowth of multiple tissues in a mosaic pattern. tumors of genitourinary tract in proteus syndrome are uncommon.201019833537
antibacterial, antifungal, and antiviral activities of some flavonoids.antibacterial and antifungal activities of six plant-derived flavonoids representing two different structural groups were evaluated against standard strains of escherichia coli, pseudomonas aeruginosa, proteus mirabilis, klebsiella pneumoniae, acinetobacter baumannii, staphylococcus aureus, enterococcus faecalis, bacillus subtilis and their drug-resistant isolates, as well as fungi (candida albicans, c. krusei) using the microdilution broth method. herpes simplex virus type-1 and parainfluenza-3 ...201019840899
[clinical aspects and epidemiology of uncomplicated cystitis in women. german results of the aresc study].uncomplicated cystitis in women is among the most frequent infections in the community setting. the german results of the international aresc study are reported concerning clinical aspects, epidemiology, and antimicrobial susceptibility of uropathogens.201019943031
comparative study on characteristics of azo dye decolorization by indigenous decolorizers.this study provides a first attempt to explore indigenous strains with excellent decolorization capability from the most biodiverse region in taiwan for dye-bearing wastewater treatment. bacterial isolates were obtained via serial selections under selection pressure of the fungicide nystatin and model textile dye(s). according to profiles of protein expression and pcr-augmented 16s rrna gene analyses for strain identification, >99% of nucleotide sequences in isolated strains were identical to ty ...201019944603
[intracranial suppurations of otorhinolaryngological origin in children in senegal].intracranial suppurations (icss) are poorly assessed in sub-saharan africa, especially in children.201019951836
modification of n-glycosylation sites allows secretion of bacterial chondroitinase abc from mammalian cells.although many eukaryotic proteins have been secreted by transfected bacterial cells, little is known about how a bacterial protein is treated as it passes through the secretory pathway when expressed in a eukaryotic cell. the eukaryotic n-glycosylation system could interfere with folding and secretion of prokaryotic proteins whose sequence has not been adapted for glycosylation in structurally appropriate locations. here we show that such interference does indeed occur for chondroitinase abc fro ...201019900493
rheumatoid arthritis, proteus, anti-ccp antibodies and karl popper.rheumatoid arthritis (ra) is a crippling joint disease affecting over 20 million people worldwide. the cause of ra is most probably linked to the triad of microbial trigger, genetic association and autoimmunity and can be explained using the philosophical method of karl popper or popperian sequences. ten "popper sequences" have been identified which point to the urinary microbe proteus mirabilis as the cause of ra: popper sequence 1 establishes that hla-dr4 lymphocytes injected into a rabbit evo ...201019895906
ciprofloxacin-induced hemorrhagic vasculitis.ciprofloxacin-induced hemorrhagic vasculitis is a rare side effect. it has only been described in 10 case reports since 1989. however, recently we were confronted with two cases within 1 month. in one patient the vasculitis resolved after termination of the ciprofloxacin therapy; in the other patient the ciprofloxacin-induced hemorrhagic vasculitis was superimposed on a severe forefoot infection, leading to progressive gangrene and a below-knee amputation. ciprofloxacin is among the standard tre ...201019892516
repression of common bull sperm flora and in vitro impairment of sperm motility with pseudomonas aeruginosa introduced by contaminated lubricant.semen collected from clinically healthy bulls at an artificial insemination centre was examined for bacterial diversity. while bacteria that are normally present in the common flora of bovine semen were absent, such as mycoplasma sp., proteus sp. and corynebacterium sp., all semen samples contained an unusually high number of pseudomonas aeruginosa strains. analysis via pulsed field gel electrophoresis demonstrated that one particular p. aeruginosa strain, present in a sealed bottle of lubricant ...201019144031
antibacterial activities of crude extract of aloe barbadensis to clinically isolated bacterial pathogens.the antibacterial activity of aloe barbadensis was tested on clinically isolated bacterial pathogens i.e. enterococcus bovis, staphylococcus aureus, escherichia coli, proteus vulgaris, proteus mirabilis, pseudomonas aeruginosa, morganella morganii, and klebsiella pneumoniae causing infection in human being. ethanolic and aqueous extracts were used for the antibacterial effect, which was measured by the appearance of zone of inhibition. relatively higher mic concentrations were obtained for gram ...201019263248
translational independence between overlapping genes for a restriction endonuclease and its transcriptional regulator.most type ii restriction-modification (rm) systems have two independent enzymes that act on the same dna sequence: a modification methyltransferase that protects target sites, and a restriction endonuclease that cleaves unmethylated target sites. when rm genes enter a new cell, methylation must occur before restriction activity appears, or the host's chromosome is digested. transcriptional mechanisms that delay endonuclease expression have been identified in some rm systems. a substantial subset ...201021092102
[a modified rat model for infection-induced stone formation].to employ a newly modified rat model for infection-induced bladder stone formation.201021092517
c-terminal fragment of amebin promotes actin filament bundling, inhibits acto-myosin atpase activity and is essential for amoeba migration.amebin [formerly termed as apabp-fi; sobczak et al. (2007) biochem. cell biol. 85] is encoded in amoeba proteus by two transcripts, 2672-nt and 1125-nt. a product of the shorter transcript (termed as c-amebin), comprising c-terminal 375 amino-acid-residue fragment of amebin, has been expressed and purified as the recombinant gst-fusion protein. gst-c-amebin bound both to monomeric and filamentous actin. the binding was ca(2+)-independent and promoted filament bundling, as revealed with the trans ...201021094125
[epidemiological and bacteriological characteristics of uropathogen bacteria isolated in a pediatric environment].urinary tract infection (uti) in children is a grave pathology, which requires a fast and effective care. bacteriological and epidemiological data play a determining role in patient's care. we report a retrospective study, which spreads out from january 1st till august 31st, 2009, having concerned hospitalized children for urinary infection in pediatrics service of farhat hached teaching hospital in sousse. our series contained 51 children with a sex ratio of 0.76, an average age of 32 months. t ...201021111582
[occurrence of 16s rrna methylase arma producing enterobacteriaceae in a general hospital in warsaw, poland].resistance to gentamicin, amikacin and kanamycin was screened in 270 clinical isolates of enterobacteriaceae originated from april 19 to may 19, 2010 in a regular hospital in warsaw, poland. most of the isolated bacteria were considered pathogenic. nineteen isolates (7%) were simultaneously resistant to two or three of the tested aminoglycosides. mics of the three aminoglycosides ranged form 128 to 1024 mcg/ml for six isolates. these isolates were suspected to produce 16s rrna methylase. genes e ...201021114012
predation of human pathogens by the predatory bacteria micavibrio aeruginosavorus and bdellovibrio bacteriovorus.the focus of this study was to evaluate the potential use of the predatory bacteria bdellovibrio bacteriovorus and micavibrio aeruginosavorus to control the pathogens associated with human infection.201021114596
ceftaroline activity against pathogens associated with complicated skin and skin structure infections: results from an international surveillance study.to assess the spectrum and potency of ceftaroline, a novel anti-methicillin-resistant staphylococcal cephalosporin, against a 2008 surveillance collection of clinical isolates from patients in the usa and europe.201021115451
clinical aspects and genetic analysis of taiwanese patients with the phenotype of hyper-immunoglobulin e recurrent infection syndromes (hies).hyper-immunoglobulin e recurrent infection syndromes (hies) has characteristic features and identified mutations. this study investigated clinical features and causal candidate mutations in taiwanese patients with the hies phenotype on referral base over 23 million inhabitants.201021120687
laboratory detection of extended-spectrum-beta-lactamase-producing enterobacteriaceae: evaluation of two screening agar plates and two confirmation techniques.the worldwide prevalence of extended-spectrum-beta-lactamase-producing esbl-producing enterobacteriaceae (esbl-e) is increasing, making the need for optimized detection techniques more urgent. in this study we investigated the performance of two esbl-e screening and two esbl-e confirmation techniques. in accordance with the dutch national guidelines (www.wip.nl), a collection of 642 highly resistant enterobacteriaceae strains, as identified by vitek2, was used to test the performances of two scr ...201021123527
necrotising otitis externa: an unusual cause of cranial nerve palsy in a diabetic haemodialysis patient.we present an unusual case of necrotising otitis externa (noe) causing a lower motor neurone facial nerve palsy in a patient with diabetes mellitus and receiving maintenance haemodialysis for end-stage renal disease (esrd). pseudomonas aeruginosa is the most common pathogen isolated in noe, although our case involved the non-typical pathogens aspergillus flavus and proteus mirabilis. we discuss the need for diagnostic rigour and the importance of considering atypical infective pathology in patie ...201021125035
a child with mental retardation and asymmetrical hypertrophy of limbs.a 5-year-old male child presented with progressively increasing asymmetrical overgrowth of limbs, hyperpigmentation on the right half of the body, and mental retardation since 9 months of age.201021132570
photodynamic therapy with a cationic functionalized fullerene rescues mice from fatal wound infections.fullerenes are under intensive study for potential biomedical applications. we have previously reported that a c60 fullerene functionalized with three dimethylpyrrolidinium groups (bf6) is a highly active broad-spectrum antimicrobial photosensitizer in vitro when combined with white-light illumination. we asked whether this high degree of in vitro activity would translate into an in vivo therapeutic effect in two potentially lethal mouse models of infected wounds.201021143031
structure of the o-polysaccharide from the lipopolysaccharide of providencia alcalifaciens o60.an o-polysaccharide (o-antigen) was isolated by mild acid degradation of the lipopolysaccharide of providencia alcalifaciens o60 and studied by sugar and methylation analyses as well as (1)h and (13)c nmr spectroscopy, including 2d roesy and (1)h,(13)c hmbc experiments in d(2)o and a roesy experiment in a 9:1 h(2)o-d(2)o mixture to reveal correlations for nh protons. it was found that the polysaccharide is built up of linear pentasaccharide repeating units containing an amide of d-glucuronic aci ...201021146157
[comparison of four phenotypic methods to detect extended-spectrum betalactamases].to compare the efficacy of four phenotypic methods for the identification of strains producing extended-spectrum β-lactamases isolated from urine cultures.201021152726
territoriality in proteus: advertisement and aggression. 201021162556
unexpected coregulator range for the global regulator lrp of escherichia coli and proteus mirabilis.the lrp/asnc family of transcription factors links gene regulation to metabolism in bacteria and archaea. members of this family, collectively, respond to a wide range of amino acids as coregulators. in escherichia coli, lrp regulates over 200 genes directly and is well known to respond to leucine and, to a somewhat lesser extent, alanine. we focused on lrp from proteus mirabilis and e. coli, orthologs with 98% identity overall and identical helix-turn-helix motifs, for which a previous study ne ...201021169483
the nationwide study of bacterial pathogens associated with urinary tract infections conducted by the japanese society of chemotherapy.this study was conducted by the japanese society of chemotherapy and is the first nationwide study on bacterial pathogens isolated from patients with urinary tract infections at 28 hospitals throughout japan between january 2008 and june 2008. a total of 688 bacterial strains were isolated from adult patients with urinary tract infections. the strains investigated in this study are as follows: enterococcus faecalis (n = 140), escherichia coli (n = 255), klebsiella pneumoniae (n = 93), proteus mi ...201021174142
synthesis and antimicrobial activity of highly functionalised novel β-lactam grafted spiropyrrolidines and pyrrolizidines.a facile and one-pot synthesis of a series of novel spiropyrrolidines/pyrrolizidines with β-lactam substituent has been accomplished through 1,3-dipolar cycloaddition reaction of alkenyl esters derived from β-lactam aldehyde as dipolarophile with the dipole azomethine ylide derived from 1,2- and 1,3-diketones and secondary amino acids. the synthesized compounds were evaluated for antimicrobial activities and found to exhibit relatively good antibacterial activity at lower concentration against f ...201021177001
asymptomatic bacteriuria among hiv positive pregnant women.the prognostic significance of asymptomatic bacteriuria resides in the observation that the prevalence is, relatively, high in persons with certain medical conditions, such as diabetes mellitus and pregnancy. this prevalence might, even, be higher in patients with human immunodeficiency virus infection. hence, this study set out to determine the prevalence of asymptomatic bacteriuria among symptom free and newly enrolled hiv infected pregnant women attending pmtct unit of antiretroviral clinic o ...201021178431
effect of neem extract against the bacteria isolated from marine fish.marine ornamental fishes are exceedingly valuable due to their high demand in domestic and international markets. there is a growing global interest to rear the fishes in captivity. but problem due to bacteria and fungi are the major hitch in captive condition. since, the use of antibiotics is banned, an attempt was made to ascertain in vitro assay of the neem leaves extract against the bacterial pathogens isolated from infected fishes. bacterial strains isolated from infected regions of the clo ...201021186711
the salmonella genomic island 1 is specifically mobilized in trans by the inca/c multidrug resistance plasmid family.the salmonella genomic island 1 (sgi1) is a salmonella enterica-derived integrative mobilizable element (ime) containing various complex multiple resistance integrons identified in several s. enterica serovars and in proteus mirabilis. previous studies have shown that sgi1 transfers horizontally by in trans mobilization in the presence of the inca/c conjugative helper plasmid pr55.201021187963
thyroid pathology in pten-hamartoma tumor syndrome: characteristic findings of a distinct entity.phosphatase and tensin homolog deleted on chromosome ten (pten)-hamartoma tumor syndrome (phts) is a complex disorder caused by germline inactivating mutations of the pten tumor suppressor gene. phts includes cowden syndrome (cs), bannayan-riley-ruvalcaba syndrome (brrs), and proteus-like syndromes. affected individuals develop both benign and malignant tumors in a variety of tissues, including the thyroid. this study is to better characterize and describe the thyroid pathology within the differ ...201021190448
[the incidence of extended spectrum beta-lactamases in proteus mirabilis strains isolated in 2007-2009].proteus sp. rods are opportunistic human pathogens, isolated mainly from urinary tract infections. they are naturally susceptible to most antimicrobials. however, acquisition of genes for extended spectrum beta-lactamases on plasmids and irrational antimicrobial treatment increase amount of multidrug resistant strains and lead to their selection. the aim of this study was to evaluate production of esbls by double disc synergy test and antimicrobial susceptibility of p mirabilis strains by disc d ...201020976952
bacteremia in a multilevel geriatric hospital.bloodstream infection (bsi) is a major cause of morbidity and mortality in hospitals. bacteremia in the elderly remains a diagnostic as well as a therapeutic challenge to the clinician.201021333922
akara ogbomoso: microbiological examination and identification of hazards and critical control points.akara ogbomoso was examined toward the establishment of hazard analysis and critical control point (haccp). the akara was produced in residential buildings with the attendant consequence of contamination. there was ample growth of aerobes, coliforms, staphylococci, shigella and yeast/mold from the samples, water and cowpea pastes. microbial contaminations occur through the processing, which can be corrected through education by adopting good hygienic and manufacturing practices. the critical con ...201021339157
prevalence of pseudomonas aeruginosa in post-operative wound infection in a referral hospital in haryana, india.the objective of our study was to determine the prevalence of pseudomonas aeruginosa in the isolates of postoperative wound and its susceptibility pattern to commonly used antibiotics.201021346900
[immunovac-vp-4 for prevention of acute respiratory diseases in children's communities].assessment of prophylactic effect of immunovac-vp-4 against acute respiratory diseases (ards) in collectives of children.201021381375
a case of disproportionate macrodactyly or a mild form of proteus syndrome? an interesting case.we present a 20-year-old malay male whom we believe has proteus syndrome, a rare congenital disorder of asymmetrical overgrowth of body tissues. there are fewer than 100 confirmed cases reported worldwide thus the clinical presentation and histopathological findings are of significance. our patient presented with an overgrown right small finger and subcutaneous purplish pigmentation over his left upper arm and chest since birth. his small finger gradually increased in size. he had no abnormaliti ...201021400985
antibiotic susceptibility pattern of urinary tract pathogens in ibadan, nigeria.urinary tract infections (uti) affect all age groups and occur in both hospitalized and non-hospitalized individuals and have serious impact on the socioeconomic life of the individual and the society, and also account for a large proportion of antibacterial drug consumption. treatment failure has been attributed to increasing resistance to common antibiotics, but there is paucity of data from this part of nigeria. this prospective study was carried out to determine the prevalence and antibiotic ...201021416786
synthesis and evaluation of a class of new coumarin triazole derivatives as potential antimicrobial agents.a series of new coumarin-based 1,2,4-triazole derivatives were designed, synthesized and evaluated for their antimicrobial activities in vitro against four gram-positive bacteria (staphylococcus aureus, mrsa, bacillus subtilis and micrococcus luteus), four gram-negative bacteria (escherichia coli, proteus vulgaris, salmonella typhi and shigella dysenteriae) as well as three fungi (candida albicans, saccharomyces cerevisiae and aspergillus fumigatus) by two-fold serial dilution technique. the bio ...201021215620
characterization of the enterobacteriaceae community that developed during storage of minced beef under aerobic or modified atmosphere packaging conditions.the whole cell protein and macrorestriction analysis of dna of enterobacteriaceae isolates recovered from minced beef stored at 0, 5, 10 and 15 °c aerobically and under modified atmosphere packaging consisting of 40% co(2)-30% o(2)-30% n(2) in the presence (map+) and absence (map-) of oregano essential oil were studied. sodium dodecyl sulphate polyacrylamide gel electrophoresis (sds-page) profiles obtained from whole cell protein analysis of the enterobacteriaceae isolates revealed seven groups. ...201021216482
antimicrobial activity of α-(2-hydroxy-2-methylpropyl)-ω-(2-hydroxy-3-methylbut-2-en-1-yl) polymethylene from caesalpinia bonducella (l.) flem.the compound, α-(2-hydroxy-2-methylpropyl)-ω-(2-hydroxy-3-methylbut-2-en-1-yl)polymethylene, isolated from ethyl acetate leaf extract of caesalpinia bonducella (l.) flem. was evaluated for antimicrobial activity against clinical isolates, proteus vulgaris, pseudomonas aeruginosa, klebsiella sp., staphylococcus citrus, staphylococcus aureus, escherichia coli, candida albicans and rhodotorula sp. using agar diffusion method. the compound exerted inhibitory zone at all concentrations and revealed t ...201021218063
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