Publications

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the in-vitro antimicrobial activity of abrus precatorius (l) fabaceae extract on some clinical pathogens.to investigate the in-vitro antimicrobial activities of the extracts of abrus precatorius on some clinical isolates as resistance to available and affordable antibiotics by these pathogens is on the increase.200818408781
some observations on the migration of proteus mirabilis and other urinary tract pathogens over foley catheters.the ability of uropathogens to migrate along external surfaces of silicone foley catheters was examined. proteus mirabilis and pseudomonas aeruginosa were the most motile organisms. p. aeruginosa migrated over both triclosan-impregnated and nitrofurazone-impregnated catheters, but these antibacterials inhibited the migration of p. mirabilis.200818419368
[etiology of community-acquired lower urinary infections and antimicrobial resistance of escherichia coli: a national surveillance study].the increasing rates of resistance exhibited by uropathogens represent a serious problem. the aim of this study was to determine, in spain, the etiology of community-acquired lower urinary infections and antimicrobial resistance of escherichia coli isolates.200818423165
[community-acquired low urinary tract infection]. 200818423168
a novel autotransporter of uropathogenic proteus mirabilis is both a cytotoxin and an agglutinin.one of the six predicted proteus mirabilis autotransporters (ats), orf c2341, is predicted to contain a serine protease motif and was earlier identified as an immunogenic outer membrane protein in p. mirabilis. the 3.2 kb gene encodes a 117 kda protein with a 58-amino-acid-long signal peptide, a 75-kda-long n-terminal passenger domain and a 30-kda-long c-terminal translocator. affinity-purified 110 kda at exhibited chymotrypsin-like activity and hydrolysed n-suc-ala-ala-pro-phe-pna and n-suc-ala ...200818430084
vascular malformation and hemangiomatosis syndromes: spectrum of imaging manifestations.objective: the purpose of this review is to describe the role of imaging and associated findings in the diagnosis of blue rubber bleb nevus syndrome, proteus syndrome, klippel-trénaunay syndrome, and kasabach-merritt syndrome. conclusion: blue rubber bleb nevus, proteus, klippel-trénaunay, and kasabach-merritt syndromes are a diverse group of vascular malformation and hemangiomatosis syndromes. both cutaneous and visceral vascular lesions are associated with these disorders. accurate diagnosis o ...200818430846
rapamycin treatment for a child with germline pten mutation.a 9-month-old boy with proteus syndrome and a de novo germline mutation in the tumor suppressor pten was referred to a specialist centre for management. over the first years of life, the patient developed life-threatening respiratory dysfunction and malnutrition because of progressive growth of hamartomas affecting the chest, mediastinum, abdomen and pelvis.200818431376
selective antimicrobial activity of maggots against pathogenic bacteria.maggot therapy, also known as biosurgery, is an ancient method for the healing of chronic infected wounds. although clinicians have reported on the beneficial activities of the lucilia sericata larvae that have been used for healing chronic wounds, the selectivity of this therapy against the different pathogenic micro-organisms that are found in chronic wounds has never been analysed. in the present study, we have investigated the in vitro activities of larval excreta/secreta both against select ...200818436596
in vitro interaction between mecillinam and piperacillin-tazobactam in the presence of azithromycin against members of the enterobacteriaceae family and pseudomonas aeruginosa.mecillinam was tested in vitro alone or in combination with piperacillin-tazobactam and azithromycin against representative species of the enterobacteriaceae family and pseudomonas aeruginosa to extend its antibacterial spectrum, and to protect mecillinam from inactivating enzymes taking advantage of the presence of tazobactam. drug interactions were studied by microdilution method, by selection of spontaneous resistant mutants on agar plates containing the drugs in combination and by time kill ...200818437840
soft tissue infections with arcanobacterium haemolyticum: report of three cases.we report here three polymicrobial wound infections associated with arcanobacterium haemolyticum in rural patients aged between 60-65 years. in two patients, one with cellulitis and the other with postoperative wound infection following amputation of the limb, arcanobacterium haemolyticum was isolated repeatedly along with beta haemolytic streptococci (bhs). the bhs belonged to lancefield's group g and group c respectively. in another patient, who was a diabetic with chronic osteomyelitis, arcan ...200818445965
secondary chromosomal attachment site and tandem integration of the mobilizable salmonella genomic island 1.the salmonella genomic island 1 is an integrative mobilizable element (ime) originally identified in epidemic multidrug-resistant salmonella enterica serovar typhimurium (s. typhimurium) dt104. sgi1 contains a complex integron, which confers various multidrug resistance phenotypes due to its genetic plasticity. previous studies have shown that sgi1 integrates site-specifically into the s. enterica, escherichia coli, or proteus mirabilis chromosome at the 3' end of thdf gene (attb site).200818446190
[pleural empyema secondary to pyonephrosis]. 200818448021
identification of a novel storage glycine-rich peptide from guava (psidium guajava) seeds with activity against gram-negative bacteria.bacterial pathogens cause an expressive negative impact worldwide on human health, with ever increasing treatment costs. a significant rise in resistance to commercial antibiotics has been observed in pathogenic bacteria responsible for urinary and gastro-intestinal infections. towards the development of novel approaches to control such common infections, a number of defense peptides with antibacterial activities have been characterized. in this report, the peptide pg-amp1 was isolated from guav ...200818448201
comparative study of electrokinetic potentials and binding affinity of lipopolysaccharides-chitosan complexes.electrokinetic properties of complexes of chitosan (ch) with lipopolysaccharides (lpss) from escherichia coli o55:b5, yersinia pseudotuberculosis 1b 598, and proteus vulgaris o25 (48/57) and their size distribution were investigated using zeta-potential distribution assay and quasi-elastic light scattering. the interaction of lps from different microorganisms with chitosan at the same w/w ratio of components (1:1) resulted in the formation of complexes in which the negative charge of lps was neu ...200818455288
effect of octenisept antiseptic on bioburden of neoplastic ulcers in patients with advanced cancer.to assess the effect of octenidine dihydrochloride (octenisept, schülke & mayr) on the clinical condition and bacterial flora in neoplastic ulcers.200818210953
in vitro activity profile of ceftobiprole, an anti-mrsa cephalosporin, against recent gram-positive and gram-negative isolates of european origin.to determine the in vitro activity profile of ceftobiprole, a pyrrolidinone cephalosporin with activity against methicillin-resistant staphylococcus aureus (mrsa), for use as a contemporary baseline to help detect any changes in its activity profile throughout the course of clinical development and use.200818218646
managing chronic otitis media with cholesteatoma report of 223 patients seen in a 5-year period.to assess the clinical features, diagnosis, and treatment of patients having chronic otitis media (com) with cholesteatoma seen in the ent/head and neck surgery clinic at the university clinical center, prishtina, kosovo.200818390126
declination of copper toxicity in pigeon pea and soil system by growth-promoting proteus vulgaris knp3 strain.the copper-resistant (1318 microm cuso(4).5h(2)o) strain knp3 of proteus vulgaris was isolated from soil near the panki power plant, kanpur, india, and was used to inoculate pigeon pea (cajanus cajan var. ups-120) seeds grown in soil for 60 days in the presence of 600 microm cuso(4).5h(2)o. a study of siderophore production (126.34 +/- 0.52 microg ml(-1)) and its subsequent effects on plant growth promotion under in situ conditions was conducted. the parameters that were monitored included the p ...200818392891
kinetic study approach of remazol black-b use for the development of two-stage anoxic-oxic reactor for decolorization/biodegradation of azo dyes by activated bacterial consortium.the laboratory-isolated strains pseudomonas aeruginosa, rhodobacter sphaeroides, proteus mirabilis, bacillus circulance, nad 1 and nad 6 were observed to be predominant in the bacterial consortium responsible for effective decolorization of the azo dyes. the kinetic characteristics of azo dye decolorization by bacterial consortium were determined quantitatively using reactive vinyl sulfonated diazo dye, remazol black-b (rb-b) as a model substrate. effects of substrate (rb-b) concentration as wel ...200818394798
[frequency and antibiotic susceptibility of bacteria identified in urine].the authors had for aim to evaluate the frequency of isolation and the antibiotic susceptibility of bacteria responsible for urinary infections among in and out-patients.200818395378
comparative activity of meropenem in us medical centers (2007): initiating the 2nd decade of mystic program surveillance.since 1997, the meropenem yearly susceptibility test information collection (mystic) program has monitored the antimicrobial activity of broad-spectrum agents against pathogens from hospitalized patients. in the united states, 2894 isolates were submitted in 2007 from 15 sites, including 1392 enterobacteriaceae, 643 nonfermentative gram-negative bacilli, and 829 gram-positive cocci. all isolates were tested by broth microdilution methods. meropenem (mic(90) range, 0.12-2 microg/ml) exhibited the ...200818329835
[etiology of urinary tract infections and antimicrobial susceptibility of urinary pathogens].with the objective of knowing the common etiological agents in urinary infection and comparing its antimicrobial susceptibility in nosocomial and community-acquired urinary infections, we analyse all the urine bacteriological exams from the serviço de patologia clínica do centro hospitalar do nordeste, epe - unidade hospitalar de bragança, during a two years period (april 2004 to march 2006). during this period, 4018 urine bacteriological exams were made. the cultural exam was positive in 572 sa ...200818331698
[classical kaposi's sarcoma in a 78-year-old woman]. 200818338143
structure, self-assembly, and dual role of a beta-defensin-like peptide from the chinese soft-shelled turtle eggshell matrix.biomineral matrix formation and molecular recognition are two important processes associated with eggshell biomineralization. to understand these two processes, a major intracrystalline peptide, pelovaterin, was isolated from turtle (pelodiscus sinensis) eggshell and its tertiary and quaternary structures were established. the global fold of pelovaterin is similar to that of human beta-defensins but has a large hydrophobic core and a short hydrophilic n-terminal segment, which is not preserved i ...200818341335
antimicrobial resistance of bacterial isolates from respiratory care wards in taiwan: a horizontal surveillance study.a horizontal surveillance study was conducted to identify common bacteria and mycobacteria from 611 respiratory aspirates and 165 urinary samples from 611 patients hospitalised at 17 respiratory care wards (rcws) in taiwan. some major resistance phenotypes, including methicillin-resistant staphylococcus aureus (mrsa), extended-spectrum beta-lactamase (esbl)-producing escherichia coli, klebsiella pneumoniae and proteus mirabilis, and multidrug-resistant pseudomonas aeruginosa (mdr-pa) and acineto ...200818358701
pharmacodynamic performance of tigecycline versus common intravenous antibiotics for the empiric treatment of complicated skin and skin structure infections.in clinical trials tigecycline was similar to vancomycin/aztreonam for complicated skin and skin structure infections, but data comparing it with other widely used antibiotics are lacking. we predicted the pharmacodynamic cumulative fraction of response (cfr) of tigecycline against bacteria implicated in complicated skin and skin structure infections and compared it with the cfrs for piperacillin/tazobactam, ceftriaxone, levofloxacin, and imipenem/cilastatin.200818363469
some microbiological aspects of rats captured alive at the port city of piraeus, greece.the aim was to investigate the presence of leptospira infection and the antibiotic resistance of enterobacteriaceae among wild rats living in a densely populated area. for this purpose 3-4 large traps were placed daily across the commercial port-front of piraeus for the duration of two months. the rats captured were transferred in the laboratory alive, where samples were freshly collected. none of the 25 rats captured was found to be infected with leptospira. only one rat was infected with salmo ...200818365804
application of capillary zone electrophoresis (cze) to the determination of pathogenic bacteria for medical diagnosis.microorganisms like bacteria, viruses, fungi, etc. have a major impact on human, animal, and plant life. several decades ago it was observed that intact cells suspended in an isotonic salt solution moved toward the anode and the mobility was proportional to the density of the charge located on the cell surfaces. since then, efforts have been made to make electrophoresis a useful tool in cell studies. microorganisms are no exception. in the present work we applied the capillary zone electrophores ...200818373084
application of two different kinds of sera against the proteus penneri lipopolysaccharide core region in search of epitopes determining cross-reactions with antibodies.proteus penneri lipopolysaccharide (lps) core regions are characterized by a greater structural variability than that observed in other enterobacteriaceae. this fact and the small amount of published data concerning the serological activity of this part of p. penneri lps prompted an examination of which fragment might determine cross-reactions with antibodies. to date, such epitopes have been found in the lps core regions of p. mirabilis and p. vulgaris strains.200818373243
complete genome sequence of uropathogenic proteus mirabilis, a master of both adherence and motility.the gram-negative enteric bacterium proteus mirabilis is a frequent cause of urinary tract infections in individuals with long-term indwelling catheters or with complicated urinary tracts (e.g., due to spinal cord injury or anatomic abnormality). p. mirabilis bacteriuria may lead to acute pyelonephritis, fever, and bacteremia. most notoriously, this pathogen uses urease to catalyze the formation of kidney and bladder stones or to encrust or obstruct indwelling urinary catheters. here we report t ...200818375554
cerebriform plantar hyperplasia: the major cutaneous feature of proteus syndrome. 200818377602
antimicrobial activity of 2,5-dihydroxy-3-methyl-1,4-benzoquinone from embelia schimperi.chromatographic separation of an ethyl acetate extract from embelia schimperi led to the isolation of a new compound identified as 2,5-dihydroxy-3-methyl-1,4-benzoquinone (1) on the basis of spectroscopic and physical data. the plant's crude extract and pure compound 1 were assayed for in vitro antimicrobial activity against clinical strains of salmonella spp., proteus spp., pseudomonas aeruginosa, klebsiella pneumoniae, escherichia coli, cryptococcus neoformans, shigella dysentriae and staphylo ...200818386487
crossed fused renal ectopia with calculi. 200818387483
skin and soft tissue infection: frequency of aerobic bacterial isolates and their antimicrobial susceptibility pattern. 200818700650
antibacterial properties of fish mucus from channa punctatus and cirrhinus mrigala.extracts and preparations made from the animal origin were used extensively in folk and modern medicine for treating many human diseases. in the present study efforts have been made to find the antimicrobial effect of the mucus of two bottom dwelling fresh water fishes namely, channa punctatus and cirrhinus mrigala. fish mucus were tested against ten pathogenic bacteria such as escherichia coli, klebsiella oxytoca, klebsiella pneumoniae, lactobacillus vulgaris, proteus mirabilis, pseudomonas aer ...200818700685
proteus rebound: reconsidering the "torture of nature".though carolyn merchant has agreed that francis bacon did not advocate the "torture of nature," she still maintains that "the very essence of the experimental method arose out of human torture transferred onto nature." her arguments do not address serious problems of logic, context, and contrary evidence. her particular insistence on the influence of the torture of witches ignores bacon's skepticism about witchcraft as superstitious or imaginary. nor do the writings of his successors sustain her ...200818702399
flavonoids from pterocaulon alopecuroides with antibacterial activity.three flavonoids, (2 r,3 r)-5,4'-dihydroxy-3'- o-methyl-7-(gamma,gamma-dimethylallyloxy)dihydroflavonol 1, (2 r,3 r)-5,7,4'-trihydroxy-3'- o-methyl-6-(alpha,alpha-dimethylallyl)dihydroflavonol 2, and (2 r,3 r)-5,7,4'-trihydroxy-6-(alpha,alpha-dimethylallyl)dihydroflavonol 3, together with three known flavonoids ( 4 - 6), were isolated from the aerial parts of pterocaulon alopecuroides. the structures of the compounds were determined by mass and by 1 d and 2 d nmr spectroscopy. screening of the a ...200818704884
hemoperitoneum increases the incidence of bacterial translocation.severe hemorrhage may induce bacterial translocation (bt) from the bowel. presence of hemoperitoneum is supposed to further increase the incidence of bt.200818705287
nasal dermoid sinus cyst in a shih tzu. 200818708657
papx, a p fimbrial operon-encoded inhibitor of motility in uropathogenic escherichia coli.motility and adherence are two integral aspects of bacterial pathogenesis. adherence, often mediated by fimbriae, permits bacteria to attach to host cells and establish infection, whereas flagellum-driven motility allows bacteria to disseminate to sites more advantageous for colonization. both fimbriae and flagella have been proven important for virulence of uropathogenic escherichia coli (upec). reciprocal regulation is one mechanism by which bacteria may reconcile the contradictory actions of ...200818710869
catheterized and non-catheterized urinary tract infections among patients attended at jimma university teaching hospital, southwest, ethiopia.prospective cross sectional study was undertaken to assess the bacterial profile and antimicrobial resistance pattern of catheterized urinary tract infection in comparison with non-catheterized uti in jimma university teaching hospital, southwest, ethiopia.200818711990
identification of virulence determinants in uropathogenic proteus mirabilis using signature-tagged mutagenesis.the gram-negative bacterium proteus mirabilis causes urinary tract infections (utis) in individuals with long-term indwelling catheters or those with functional or structural abnormalities of the urinary tract. known virulence factors include urease, haemolysin, fimbriae, flagella, dsba, a phosphate transporter and genes involved in cell-wall synthesis and metabolism, many of which have been identified using the technique of signature-tagged mutagenesis (stm). to identify additional virulence de ...200818719175
effect of triclosan on the formation of crystalline biofilms by mixed communities of urinary tract pathogens on urinary catheters.the crystalline bacterial biofilms that encrust foley catheters compromise the care of many elderly and disabled patients. the aim of this study was to examine whether the biocide triclosan can prevent encrustation by the mixed flora of uropathogens that commonly infect patients undergoing long-term catheterization. models of the catheterized bladder were inoculated with communities of organisms isolated from patients who were experiencing catheter blockage. the catheter retention balloons were ...200818719184
[antimicrobial resistance of uropathogens among outpatients, 2000-2004].a retrospective study based on the electronic database of a university hospital was carried out to investigate the prevalence of etiological agents and their susceptibilities to antibiotics, among adult outpatients (> 18 years old) with urinary tract infections. nine hundred and fifty-seven positive urine cultures were identified between january 2000 and december 2004. escherichia coli, proteus mirabilis and klebsiella sp were the three principal bacterial etiological agents. trimethoprim-sulfam ...200818719808
design, synthesis, and evaluation of novel organophosphorus inhibitors of bacterial ureases.a new group of organophosphorus inhibitors of urease, p-methyl phosphinic acids was discovered by using the structure based inhibitor design approach. several derivatives of the lead compound, aminomethyl(p-methyl)phosphinic acid, were synthesized successfully. their potency was evaluated in vitro against urease from bacillus pasteurii and proteus vulgaris. the studied compounds constitute a group of competitive, reversible inhibitors of bacterial ureases. obtained thiophosphinic analogues of th ...200818717581
antibacterial activity of halogenated sesquiterpenes from malaysian laurencia spp.during our studies on malaysian laurencia species, brominated metabolites, tiomanene, acetylmajapolene b, and acetylmajapolene a were isolated from an unrecorded species collected at pulau tioman, pahang along with known majapolene b and majapolene a. acetylmajapolene a was a mixture of diastereomers as in the case of majapolene a. tiomanene may be a plausible precursor for acetylmajapolenes b and a. in addition, three known halogenated sesquiterpenes and two known halogenated c(15) acetogenins ...200818718619
urinary infections due to multi-drug-resistant escherichia coli among persons with hiv disease at a tertiary aids care centre in south india.while the spectrum of opportunistic infections due to hiv infection has been widely discussed, there are very limited data available in south india on certain incident infections especially urinary tract infections (uti) in hiv-infected subjects.200818724067
zapa, a virulence factor in a rat model of proteus mirabilis-induced acute and chronic prostatitis.our knowledge of pathogenesis has benefited from a better understanding of the roles of specific virulence factors in disease. to determine the role of the virulence factor zapa, a 54-kda metalloproteinase of proteus mirabilis, in prostatitis, rats were infected with either wild-type (wt) p. mirabilis or its isogenic zapa(-) mutant kw360. the wt produced both acute and chronic prostatitis showing the typical histological progressions that are the hallmarks of these diseases. infection with the z ...200818725420
purple urine bag syndrome. 200818725621
genetic and phenotypic heterogeneity in the pten hamartoma tumour syndrome.germline pten (phosphatase and tensin homologue deleted on chromosome ten) mutations predispose to phenotypically diverse disorders that share several overlapping clinical features: cowden syndrome, bannayan-riley-ruvalcaba syndrome, proteus syndrome and proteus-like syndrome, collectively classified as pten hamartoma tumour syndrome (phts). the meticulous acquisition and documentation of phts phenotypic data at different levels and the profiling of the plethora of genetic changes in pten and ot ...200818794875
congenital lipomatous overgrowth, vascular malformations, and epidermal nevi (clove) syndrome: cns malformations and seizures may be a component of this disorder.a newborn girl was found to have a massive lymphatic truncal vascular malformation with overlying cutaneous venous anomaly associated with overgrown feet and splayed toes. these manifestations comprise the recently described clove syndrome. she also had cranial asymmetry and developed generalized seizures, which were treated with anticonvulsants. cranial ct showed encephalomalacia, widening of the ventricles and the sulci, hemimegalencephaly (predominantly white matter) and partial agenesis of c ...200818816642
molecular identification of streptococcus equi subsp. equi and streptococcus equi subsp. zooepidemicus in nasal swabs samples from horses suffering respiratory infections in iran.the objective of this study was to evaluate the existence of streptococcus equi subsp. equi and streptococcus equi subsp. zooepidemicus as probable agents associated with naturally occurring infection of the equine upper respiratory disease in mashhad area. nasal swabs samples from thirty horses with upper respiratory tract infections were collected. the bacteria isolated and identified were streptococcus equi subsp. equi (1 isolate), streptococcus equi subsp. zooepidemicus (25 isolates), pasteu ...200818817175
inhibitory effects of sage extract on the growth of enteric bacteria.antibacterial activity of sage extract at concentrations of 0.1, 0.05, 0.025, 0.0125, 0.00625, 0.003125, 0.00156, 0.0005 and 0.00025 g dl(-1) against salmonella typhi, shigella sonnei, s. flexneri, proteus vulgaris, staphylococcus aureus, etec escherichia coli and pseudomonas aeruginosa was evaluated. susceptibility testing of bacterial strains against 18 antibiotics was also performed for comparison. the results showed that p. aeruginosa and etec e. coli were completely resistant to sage extrac ...200818817180
antibacterial activity of the fruits of iranian torilis leptophylla against some clinical pathogens.the aim of this study was to examine the antimicrobial activity of the methanolic extract of torilis leptophylla was tested on eleven bacteria (bacillus anthracis, bacillus subtilis, bacillus pumilus, staphylococcus aureus, bacillus licheniformis, brucella melitensis, escherichia coli, salmonella typhi, proteus mirabilis, bordetella bronshiseptica and pseudomonas aeruginosa). tested extract was effective against all bacteria but not b. subtilis. consequently, the ethanolic extract had antibacter ...200818819541
non-susceptibility trends among enterobacteriaceae from bacteraemias in the uk and ireland, 2001-06.enterobacteriaceae are common agents of bacteraemia, with escherichia coli accounting for 20% of the cases. reflecting this importance, members of the family constitute 4 of the 12 collection groups in the british society for antimicrobial chemotherapy (bsac) bacteraemia surveillance programme.200818819979
inhibition of candida albicans isocitrate lyase activity by sesterterpene sulfates from the tropical sponge dysidea sp.seven sesterterpene sulfates (1-7) were isolated from the tropical sponge dysidea sp. and their inhibitory activities against isocitrate lyase (icl) from candida albicans were evaluated. among the isolated natural products compound 6 and 7 were found to be strong icl inhibitors. the isolated compounds (1-7) also showed potent antibacterial effect against bacillus subtilis and proteus vulgaris, but did not display antifungal activity.200818824352
causative agents of urinary tract infections in children and their antibiotic sensitivity pattern: a hospital based study.a retrospective study was conducted to find out the causative agents of urinary tract infection (uti) in children and their antibiotic sensitivity pattern among nepalese children. this was done at kanti children's hospital in kathmandu (nepal) by analyzing the records of urine samples collected for culture and sensitivity tests over a period of six months (april to november, 2007). of the total 1878 mid-stream urine samples collected from suspected cases of uti, 538 (28.6%) were positive for pat ...200818828428
distribution frequency of pathogenic bacteria isolated from cutaneus leishmaniasis lesions.cutaneous leishmaniasis (cl) is a parasitic disease characterized by single or multiple ulcerations. secondary bacterial infections are one of the complications that can increase the tissue destruction and the resulting scar. to better determine the incidence of real secondary bacterial infections in cl, we designed the current study. this was a cross-sectional study performed in skin diseases and leishmaniasis research centre, isfahan, iran. a total of 1,255 patients with confirmed cl enrolled ...200818830062
[the analysis of the bacterial and fungal flora in maxillary sinuses in patients operated due to fess method].the aim of this work was to analyse the bacterial and fungal flora in maxillary sinuses in patients operated due to the fess method.200818837224
[macrodactylies of the hand and foot].macrodactyly is a rare congenital anomaly defined by an enlargement of all the structures of fingers or toes. two forms of macrodactyly have been described. one form is static with an enlargement present at birth and growing proportionately to the other digits. the other is progressive with an enlargement beginning in early childhood and growing faster than that of the normal digits. macrodactyly is responsible of a functional handicap and an aesthetic prejudice. treatment may be indicated for t ...200818842439
uropathogens and host characteristics.uropathogens other than escherichia coli occur with greater frequency in patients with risk factors for urinary tract infection (uti). however, little is known about associations between uropathogen species and host characteristics. three hundred nineteen urine specimens containing a balanced distribution of uropathogen species were selected from inpatients and outpatients at a university hospital clinical microbiology laboratory. information on host characteristics was retrospectively collected ...200818842936
[fluoroquinolones and gram-negative bacteria: antimicrobial activity and mechanisms of resistance].fluoroquinolones acts by interacting with type ii topoisomerases (dna gyrase and topoisomerases iv). related to this mechanism of action, bacteria have developed resistance mechanisms consisting in some target mutations (gyra/gyrb for dna gyrase and parc/pare for topoisomerase iv) or in a reduced access to the target itself, by either decreased permeability or augmented expression of efflux pumps, such as acrab and mexab. along with these classical mechanisms of chromosomal resistance, the prese ...200818843219
experimental and qsar of acetophenones as antibacterial agents.antibacterial activity of 20 acetophenone derivatives was evaluated against two gram-positive and three gram-negative organisms, namely, bacillus subtilis ncim 2718, staphylococcus aureus ncim5021, salmonella typhi ncim2501, enterobacter aerogenes ncim5139, and proteus vulgaris ncim2813 by two-fold dilution method. the most active amongst this group of compounds were 4-methyl, 2-hydroxy, 3-bromo, 4-ethoxy, 3-nitro and 4-nitro acetophenones. quantitative structure-activity relationships were deve ...200818844677
[recent evolution and characterization of extended-spectrum beta-lactamase producing enterobacteria in the chu of nice (2005-2007)].esbl producing enterobacteria (e-esbl+) are always a public health concern, mainly due to increase of ctx-m beta-lactamase. so, 542 new strains were isolated in the chu de nice during the 2005-2007 period. the aim of this work was to characterize the esbl and to type isolates suspected to be implicated in outbreaks.200818848404
surface acoustic wave biosensor as a tool to study the interaction of antimicrobial peptides with phospholipid and lipopolysaccharide model membranes.surface acoustic wave biosensors are a powerful tool for the study of biomolecular interactions. the modulation of a surface-confined acoustic wave is utilized here for the analysis of surface binding. phase and amplitude of the wave correspond roughly to mass loading and viscoelastic properties of the surface, respectively. we established a procedure to reconstitute phospholipid and lipopolysaccharide bilayers on the surface of a modified gold sensor chip to study the mode of action of membrane ...200818605705
cricothyroidotomy vs. sternal tracheotomy for challenging airway anatomy.although tracheotomies are the standard procedure for elective surgical airways, some patients present with challenging anatomy. in circumstances of abnormal skeletal deformities, such as kyphoscoliosis, the airway is also often tortuous and access to the trachea may be difficult. in the situation of severely distorted tracheal anatomy, where access to the trachea may require a mediansternotomy, a cricothyroidotomy may be the safer option. this article details the technique involved in approachi ...200818607301
synthesis and antimicrobial studies of novel 1-benzhydryl-piperazine sulfonamide and carboxamide derivatives.a series of novel substituted 1-benzhydryl-piperazine sulfonamide 8(a-f) and benzamides 9(a-h) were synthesized and their antimicrobial activities evaluated in vitro by paper disc diffusion and micro dilution method against standard strains of gram-positive (staphylococcus aureus atcc 25953, staphylococcus epidermis 25212, bacillus cereus 11778, bacillus substilis 6051) and gram-negative (escherichia coli atcc 25922, pseudomonas aeruginosa atcc 2853, proteus vulgaris atcc 2853 and salmonella typ ...200818608768
asymptomatic bacteriuria in the elderly: high prevalence and high turnover of strains.asymptomatic bacteriuria (asb) was followed in repeated prevalence surveys in a cohort of non-institutionalized residents (n=330), aged>or=80 y. urine samples were collected at baseline, and at 6, and at 18 months. phenotyping (pheneplate) was performed on isolates of escherichia coli to evaluate strain relatedness. asb occurred in 19.0, 19.4, and 19.9% in women, and in 9.4, 9.6 and 7.9% in men, at baseline and at the 6- and 18-months follow-up, respectively, and asb was found at least once in 3 ...200818609196
bsac standardized disc susceptibility testing method (version 7).the changes that have been made to the previous version of the recommendations (version 6) are as follows: medium and incubation condition for testing acinetobacter spp. (tables 1 and 6); use of cefoxitin as an indicator antibiotic for detecting methicillin/oxacillin/cefoxitin resistance in coagulase-negative staphylococci (tables 1, 6 and 11); mic breakpoint for co-trimoxazole based on the trimethoprim concentration in a 1:19 combination with sulfamethoxazole (tables 7, 10, 11, 12, 15, 16 and 1 ...200818474513
optimal probe length and target location for electrochemical detection of selected uropathogens at ambient temperature.we have previously demonstrated the clinical validity of the rapid detection of uropathogens by use of a dna biosensor. this assay involves the hybridization of capture and detector probe pairs with bacterial 16s rrna target molecules to form a dna-rna sandwich on the sensor surface. horseradish peroxidase-conjugated antibody binds to the detector probe to enzymatically amplify the hybridization signal. these previous studies involved the hybridization of bacterial 16s rrna target sequences with ...200818562584
multiple feather follicle cysts in a moroseta hen (gallus gallus).an 8-month-old white feathered, black skinned moroseta hen was presented for examination because of numerous 2 mm- to 30 mm-diameter irregularly shaped, hard nodules in the skin of the head, wings, back, and abdomen. the nodules were confined to the skin and did not involve subcutaneous tissues. nodules consisted of dilated feather follicles packed with a caseous tan-to-pale-yellow material admixed with feather remnants. histologically, affected feather follicles were markedly dilated and filled ...200818646468
pyelo-hepatic fistula.a 43-year-old woman with hypertension presented to the emergency department with oliguria, fever, and abdominal pain. physical examination and laboratory evaluation revealed sepsis and acute renal failure. blood culture yielded proteus mirabilis. imaging studies showed markedly enlarged right kidney with abscess communicating with liver. to our knowledge, this is the first report of pyelo-hepatic fistula.200818649927
biodegradation of reactive blue 59 by isolated bacterial consortium pmb11.morphologically different, three bacterial strains, capable of decolorizing reactive blue 59 were isolated from dye effluent contaminated soil sample, collected from ichalkaranji, india. the individual bacterial strains viz. bacillus odysseyi suk3, morganella morganii suk5 and proteus sp. suk7 decolorized reactive blue 59 (50 mg l(-1)) completely within 60, 30, 24 h, respectively, while the bacterial consortium pmb11 of these strains required 3 h for the complete decolorization. the decolorizati ...200818661161
approach in an adolescent proteus male patient with megafoot.proteus syndrome is a rare overgrowth syndrome characterized by hemihypertrophy, lower limb asymmetry, hyperpigmentations, lipomas, and vascular malformation. in this paper, we present a new adolescent proteus syndrome patient with bilateral megafoot. he was very successful in playing football and was very popular among his friends. we present this case for the psychological and surgical aspects of this very interesting entity. we also review the recent literature related with proteus syndrome.200818664091
structure and serological properties of the o-antigen of two clinical proteus mirabilis strains classified into a new proteus o77 serogroup.two proteus mirabilis strains, 3 b-m and 3 b-k, were isolated from urine and faeces of a hospitalized patient from lodz, poland. it was suggested that one strain originated from the other, and the presence of the bacilli in the patient's urinary tract was most probably a consequence of autoinfection. the o-polysaccharide was obtained by mild acid degradation of the lipopolysaccharide of p. mirabilis 3 b-m and studied by sugar analysis and nuclear magnetic resonance spectroscopy, including two-di ...200818665848
effects of proteus mirabilis lipopolysaccharides with different o-polysaccharide structures on the plasma membrane of human erythrocytes.the effects of o33 and o49 p. mirabilis lipopolysaccharides (lpss) on human erythrocyte membrane properties were examined. physical parameters of the plasma membrane, such as membrane lipid fluidity, physical state of membrane proteins, and osmotic fragility, were determined. the fluidity of the lipids was estimated using three spin-labeled stearic acids of doxyl derivatives: 5-doxylstearic acid, 12-doxylstearic acid, and 16-doxylstearic acid. all the applied labels locate to different depths of ...200818669036
tigecycline: a critical update.tigecycline is the first food and drug administration (fda) approved glycylcycline antibiotic. it has shown remarkable in vitro activity against a wide variety of gram-positive, gram-negative and anaerobic bacteria including many multidrug resistant (mdr) strains. however, it has minimal activity against pseudomonas aeruginosa and proteus spp. to date, little resistance to tigecycline has been reported. clinical trials studying complicated skin and skin-structure infections (csssis) demonstrated ...200818676218
proteus syndrome complicated by multiple spinal meningiomas.proteus syndrome is a complex and highly variable disorder comprising malformations and overgrowth of multiple tissues. we present a 65-year-old japanese man who had multiple spinal meningiomas and accompanying neural symptoms. his right leg showed hypertrophy with cerebriform connective-tissue naevus on the sole, and macrodactyly. chest computed tomography imaging revealed mild cystic and emphysematous lung changes, which were possibly related to proteus syndrome. otherwise, he had no particula ...200818681877
[intestinal enterobacteria of the hibernating apis mellifera mellifera l. bees].dynamics of enterobacteria of normal intestinal microflora was studied in apis mellifera mellifera l. bees hibernating under snow in the western urals. the cell numbers (n) of the predominant species klebsiella oxytoca increased from 10-10(6) cfu/bee in november 2004 to 10(4)-10(7) cfu/bee in march 2005; its frequency of occurrence (p) increased from 92 to 100%. increase of providencia rettgeri (11.2004: n up to 10(6), p 25%; 03.2005: n 10(2)-10(6), p 80%) was accompanied by the substitution of ...200818683661
the pathological newborn in small animals: the neonate is not a small adult.the rate of perinatal death is variable but highest during parturition, immediately after birth and in the first days of life. infectious diseases, above all bacterial, are the second most important cause of mortality after losses during parturition. a lot of factors are involved predisposing puppies and kittens to bacterial infections: respiratory distress, hypothermia, hypoglycaemia, dehydration, congenital abnormalities. e. coli, streptococci and staphylococci, klebsiella sp., pseudomonas sp. ...200818688749
[current issues related to nosocomial infections in general surgery].the authors analyze the prevalence of nosocomial infections in their facility between 1999 and 2006. the annual rates ranged from 1.92 % to 4.24 %, with an average prevalence of 3.12 %. the most frequent were wound infections, febrile conditions associated with positive blood culture and urinary tract infections. in nosocomial infections, the average length of hospitalization increased by a factor of 3.5 and treatment costs rose. sporadically, multiresistant strains were detected, such as mrsa, ...200818688770
dna fragmentation in microorganisms assessed in situ.chromosomal dna fragmentation may be a direct or indirect outcome of cell death. unlike dna fragmentation in higher eukaryotic cells, dna fragmentation in microorganisms is rarely studied. we report an adaptation of a diffusion-based assay, developed as a kit, which allows for simple and rapid discrimination of bacteria with fragmented dna. intact cells were embedded in an agarose microgel on a slide, incubated in a lysis buffer to partially remove the cell walls, membranes, and proteins, and th ...200818689511
synthesis of some novel imidazole-based dicationic carbazolophanes as potential antibacterials.synthesis of fluorescent imidazole-based dicationic carbazolophanes incorporating various spacer units is described. interestingly, the cyclophanes 2a and 5a incorporating a pyridine moiety exhibited superior antibacterial activity against most of the pathogenic bacteria in the tested concentrations as compared to the other cyclophanes as well as the test control, benzalkonium chloride (bac), cetylpyridinium chloride (cpc) and tetracycline.200818620857
genetic determinants of self identity and social recognition in bacteria.the bacterium proteus mirabilis is capable of movement on solid surfaces by a type of motility called swarming. boundaries form between swarming colonies of different p. mirabilis strains but not between colonies of a single strain. a fundamental requirement for boundary formation is the ability to discriminate between self and nonself. we have isolated mutants that form boundaries with their parent. the mutations map within a six-gene locus that we term ids for identification of self. five of t ...200818621670
proteus' syndrome as a differential diagnosis of vascular malformations. 200818622970
serotyping of clinical isolates belonging to proteus mirabilis serogroup o36 and structural elucidation of the o36-antigen polysaccharide.the o-specific polysaccharide (ops) isolated from the lipopolysaccharide of proteus mirabilis o36 was found to have a pentasaccharide repeating unit of the following structure: -->2)-beta-d-ribf-(1-->4)-beta-d-galp-(1-->4)-alpha-d-glcpnac6ac-(1-->4)-beta-d-galp-(1-->3)-alpha-d-glcpnac-(1-->. the structure is unique among proteus ops, which is in agreement with the classification of this strain into a separate proteus o-serogroup. remarkably, the p. mirabilis o36-polysaccharide has the same struc ...200818625011
outer membrane antigens of the uropathogen proteus mirabilis recognized by the humoral response during experimental murine urinary tract infection.proteus mirabilis, a gram-negative bacterium, is a frequent cause of complicated urinary tract infections in those with functional or anatomical abnormalities or those subject to long-term catheterization. to systematically identify surface-exposed antigens as potential vaccine candidates, proteins in the outer membrane fraction of bacteria were separated by two-dimensional gel electrophoresis and subjected to western blotting with sera from mice experimentally infected with p. mirabilis. protei ...200818625734
hemihypertrophy in a neonate. 200818626110
monozygotic twins discordant for proteus syndrome.proteus syndrome is a rare, complex disorder predominantly characterized by asymmetric overgrowth of body parts, connective tissue and epidermal nevi, and vascular malformations. general diagnostic criteria comprise mosaic distribution, sporadic occurrence, and progressive course. we report on proteus syndrome in discordant monozygotic twins. the affected 9-year-old boy showed progressive postnatal overgrowth of his right leg and foot and asymmetric progressive overgrowth of single toes with a s ...200818627057
the lon protease regulates swarming motility and virulence gene expression in proteus mirabilis.a mini-tn5lacz1 transposon insertion in a gene encoding an orthologue of the lon protease conferred a hyper-swarming phenotype on proteus mirabilis. the lon mutation increased the accumulation of mrna for representative class 1 (flhdc), class 2 (flia) and class 3 (flaa) genes during swarmer cell differentiation. in addition, the stability of the flhd protein was fourfold higher in the lon : mini-tn5lacz1 background. expression of a single-copy lon : lacz fusion increased during the swarming cycl ...200818628491
quantification of proteus mirabilis virulence factors and modulation by acylated homoserine lactones.measurement of the main proteus mirabilis virulence factors would increase our understanding of how the organism infects and colonizes the urinary tract. the purpose of this study was to quantify the virulence factors of twelve p. mirabilis laboratory strains and to determine whether expression of virulence factors of p. mirabilis depends on the presence of homoserine-lactone derivatives.200818629420
repression of motility during fimbrial expression: identification of 14 mrpj gene paralogues in proteus mirabilis.proteus mirabilis alternates between motile and adherent forms. mrpj, a transcriptional regulator previously reported to repress motility, is encoded at the 3' end of the mrp fimbrial operon in p. mirabilis. sequencing of the p. mirabilis genome revealed 14 additional paralogues of mrpj, 10 of which are associated with fimbrial operons. twelve of these genes, when overexpressed, repressed motility; several distinct patterns of swarming motility were noted. expression of 10 of the 14 mrpj paralog ...200818630347
detection of kpc-2 in a clinical isolate of proteus mirabilis and first reported description of carbapenemase resistance caused by a kpc beta-lactamase in p. mirabilis.an isolate of proteus mirabilis recovered from blood cultures of a diabetic patient was shown to be resistant to imipenem, meropenem, and ertapenem by disk diffusion susceptibility testing. amplification of whole-cell and/or plasmid dna recovered from the isolate with primers specific for the bla(kpc) carbapenemase gene produced an amplicon of the expected size which was confirmed to be bla(kpc-2) by sequence analysis. transformation of a susceptible escherichia coli host with plasmid preparatio ...200818632900
[investigation on species composition of cockroaches and bacteria-carrying on their bodies in five cities of hainan]."za-type" cages were used to capture cockroaches in 267 sites of 5 cities in hainan. species were identified and bacteria were isolated by routine method. 441 cockroaches were collected and identified as five species belonging to two genera, 75.3% being periplaneta americana. more cockroaches were found in sewerage. bacteria were detected from 82.4% of cockroaches, including escherichia coli, pseudomonas aeruginosa, salmonella sp, staphylococcus aureus, shigella sp, bacillus proteus and sort of ...200818637594
antimicrobial activity of acanthus ilicifolius (l.).the antimicrobial activity of alcoholic, butanolic and chloroform extracts of leaves and roots of the plant acanthus ilicifolius ware studied. ampicillin and clotrimazole were used as standard antibacterial and antifungal agents respectively. the result of the study revealed that the alcoholic extract and chloroform extract of leaves exhibited strong inhibitory action against bacillus subtilis, staphylococcus aureus, candida albicans, aspergillus fumigatus and aspergillus niger and moderate inhi ...200821369453
microbial burden of some herbal antimalarials marketed at elele, rivers state.herbal antimalarials still remain an alternative to our traditional communities who can not afford orthodox antimalarials. this study was aimed at investigating the microbial quality of six herbal antimalarials using standard microbiological methods. of the six preparations analyzed, "schnapps", palm wine and water were the media of preparation; the water base preparations recorded higher microbial load. the mean microbial load was 159.5 × 10(5) cfu/ml and 217.4 × 10(2)cfu/ml in water and alcoho ...200921304626
[is prophyilaxis necessary after urodynamic tests? our experience.]urodynamic studies should be performed only on patients with sterile urine. the use of prophylaxis after urodynamic investigation is debated (positive urinoculture in 9 to 15% of cases). the units of urodynamics at the urological clinic of the university of genoa and of the galliera hospital of genoa assessed the prevalence of bacteriuria on a sample of 336 patients (314 females and 22 males), average age 62.3, between january and december 2006. all patients with sterile urine before examination ...200921086306
antibacterial iridoid glucosides from eremostachys laciniata.eremostachys laciniata (l) bunge (family: lamiaceae alt. labiatae; subfamily: lamioideae) is one of the 15 endemic iranian herbs of the genus eremostachys. a decoction of the roots and flowers of e. laciniata has traditionally been taken orally for the treatment of allergies, headache and liver diseases. three antibacterial iridoid glucosides, phloyoside i (1), phlomiol (2) and pulchelloside i (3) have been isolated from the rhizomes of this plant. the structures of these compounds were elucidat ...200918693303
recombinant expression, purification, and biochemical characterization of chondroitinase abc ii from proteus vulgaris.chondroitin lyases (or chondroitinases) are a family of enzymes that depolymerize chondroitin sulfate (cs) and dermatan sulfate (ds) galactosaminoglycans, which have gained prominence as important players in central nervous system biology. two distinct chondroitinase abc enzymes, cabci and cabcii, were identified in proteus vulgaris. recently, cabci was cloned, recombinantly expressed, and extensively characterized structurally and biochemically. this study focuses on recombinant expression, pur ...200918849565
synthesis and biological activities of new hydrazide derivatives.the synthesis of a new series of imidazo[1,2-a]pyrazine-2-carboxylic acid arylidene-hydrazides is described. the chemical structures of the compounds were elucidated by ir, (1)h-nmr, fab(+)-ms spectral data. their biological activity against various bacteria, fungi species, and mycobacterium tuberculosis was investigated. antibacterial activity was measured against escherichia coli (nrrl b-3704), staphylococcus aureus (nrrl b-767), salmonella typhimurium (nrrl b-4420), proteus vulgaris (nrll b-1 ...200918825530
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