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[therapeutic effect of sulfobenzyl-penicillin (sb-pc) on the concentration of sb-pc in human bile (author's transl)].sulfobenzyl-penicillin (sb-pc) is currently being investigated for use in man. the purpose of this study was to evaluate effect of sb-pc on salmonella typhosa and biliary excretion of sb-pc in disease of the biliary tract. 1) clinically, typhoid carriers without cholelithiasis were initiated with 4.0 g/day of sb-pc. stool and bile became negative for salmonella typhosa 14 days after initial treatment. 2) in typhoid carriers with cholelithiasis, salmonella typhosa were not isolated from bile, wal ...19751195516
on the nature of hyaline zones in the cytoplasm of amoeba proteus.investigations with the nomarski dic (differential interferece contrast) microscope and the electron microscope on the nature of hyaline zones in the cytoplasm of amoeba proteus revealed that these regions represent pure ground cytoplasm. differences between specimens 1) treated with 2% ethanol, 2) released from high hydrostatic pressure or 3) preincubated at 35 degrees c for 30 minutes could not be observed. only dying cells undergoing lysis contained a watery solution within the zones of hyali ...19751196142
four hour-test for the identification of enterobacteriaceae.a set of 12 rapid biochemical tests--lysinedecarboxylase, ornithinedecarboxylase, beta-galactosidase, urease, hydrogensulphide, indole, acetoin, deoxyribonuclease, esculin, mannitol, raffinose and sorbitol--were selected from an original set of 13 tests and were found to give 98% accurate reactions within 4 hrs of incubation for the identification of bacteria belonging to enterobacteriaceae. this set permits identification on the genus and/or species level for escherichia, shigella, citrobacter, ...19751196260
[clinical x-ray characteristics of acute suppurative destructions of the lungs of a nonstaphylococcal nature in children].the authors conducted complex clinico-roentgenological and immuno-bacteriological studies in 63 children, aged from 14 days to 14 years, with acute suppurative destructions of the lung, complicated with the development of pyothorax. as a result of these investigations, it was found that clinico-roentgenological symptomatics in children with acute suppurative destructions of the lung of the non-staphylococcal nature (proteus, pyocyanic bacillus and others) show evident peculiarities and differ fr ...19751198828
new thoughts concerning xanthogranulomatous pyelonephritis (x-p).a clinical and roentgenographic analysis of 13 patients with pathologically proved xanthogranulomatous pyelonephritis (x-p) has demonstrated that many previously accepted truisms associated with this disease may not be valid. as a result of this study it is suggested that x-p: 1. does have a prominant female distribution. 2. may arise relatively acutely. 3. can be associated with a well-functioning kidney. 4. may destroy the kidney and collecting system. 5. does not demonstrate neovascularity. 6 ...19751200208
[etiology of acute suppurative destructive pneumonias in children].clinical, immunological and bacteriological studies were carried out in 63 children with the so-called staphylococcus destruction of the lungs. it was shown that in some of the cases destructive process in the lungs, along with the pathogenic staphylococcus, could be caused by the gram negative bacteria (proteus, bac. pyocyaneus, etc.). it was found that in children of different age groups the titre of antistaphylococcus antibodies up to 0.5 au/ml was normal and pointed to the absence of any inf ...19751202883
[differentiation of proteus-providencia group bacteria according to the fatty acid makeup determined by a gas chromatographic method]. 19751206145
[urease activity of proteus]. 19751207522
[diagnosis of dysbacteriosis in infants]. 19751208158
in vitro activity and pharmacokinetics in patients of cefamandole, a new cephalsoporin antibiotic.cefamandole nafate, a new cephalosporin for parenteral use, was evaluated in vitro against 231 recent clinical isolates and in 12 patients. cefamandole had activity equivalent to cefazolin against staphylococcus aureus, escherichia coli, and klebsiella pneumoniae. cefamandole was more active than cephalothin or cefazolin against proteus mirabilis. both cefamandole and cefazolin were as active as cephalothin against s. aureus, were slightly more active against k. pneumoniae, and were considerably ...19751211920
comparison of the antibacterial activities of sisomicin and gentamicin against gram-negative bacteria.sisomicin was found to be more active on a weight basis than gentamicin against pseudomonas sp., klebsiella sp., and indole-positive proteus. gentamicin was more active than sisomicin against escherichia coli, serratia sp., enterobacter sp., and proteus mirabilis. both antibiotics were very active against methicillin-resistant strains of staphylococcus aureus.19751211927
an evaluation of two methods of bacteriocine typing of organisms of the genus proteus.an assessment of two simple methods of typing proteus isolates using bacteriocines is described. the methods chosen were those of cradock-watson and al-jumaili. it has been shown that the use of liquid bacteriocine preparations is more satisfactory than methods involving proteocine production in solid media. for example, no non-typable isolates were encountered and a large number of strains were demonstrated. this method is therefore proposed for use in a routine diagnostic laboratory.19751214011
deoxyribonuclease release by incompatible strains of proteus.using incompatible strains of proteus growing on the same deoxyribonuclease (dnase) agar plate, it was found that dnase is consistently released at the demarcation line. dnase was shown to be released when the swarming organisms were killed. while screening enterobacteriaceae according to the method of schreier (1969) on agar containing deoxyribonucleic acid (dna), it was noticed that when dissimilar strains of proteus met, there was a breakdown of dna. schreier (1969) reported that, of the ente ...19751217270
[nutrition and taxonomy of "enterobacteriaceae" and related bacteria. ii. general results and classification (author's transl)].a study of 186 strains belonging to eleven genera of the family enterobacteriaceae and to three genera of the family vibrionaceae has been carried out in order to determine their "versatility" towards 146 organic substrates tested as sole source of carbon and energy. glucose was the only substrate used by all the strains; gluconate and glycerol were used by respectively 184 and 185 strains; 55 substrates were used by no one strains. the 90 substrates which were used by a fraction of the strains ...19751217783
[nutrition and taxonomy of "enterobacteriaceae" and related bacteria. iii. nutritional characters and differentiation of the taxonomic groups (author's transl)].a batch of 186 strains belonging to the families enterobacteriaceae or vibrionaceae has been studied by determination, for each strain, of the "versatility" towards 146 organic substrates tested as sole source of carbon and energy. this study allowed to work out a classification of these strains into the 32 classes which have been previously described. in the present paper the nutritional characters of these classes are reported. on the basis of these characters, the 32 classes may be regrouped ...19751217784
[incompatibility during transplantation of nuclei in amoeba. iv. transplantation compatibility in different strains of amoeba proteus].seven laboratory amoeba proteus strains of different origin were tested for their transplantation compatibility (i.e. viability of artificially produced heterokaryons) in all possible pair combinations. incompatible combinations (14) as well as completely compatible ones (7) were found. compatibility was distributed among strain combinations non-randomly. all the strains studied could be classified into three groups with respect to compatibility ("compatibility groups") involving 1, 2 and 4 stra ...19751218727
[etiology and characteristics of clinical course of nonspecific colpitis]. 19751220567
[expansion phenomena of proteus cultures. i. the swarming expansion (author's transl)].the expansion of proteus cultures on nutrient agar plates is in general attributed to negative chemotaxis with regard to a metabolic product of the culture itself. the initial latency of several hours is assumed to be the time necessary for the production and imbibition of the nutrient with the incriminated metabolite. in the present paper it will be shown that independent of this delayed expansion (expansion with initial latency) there also exists an immediate expansion that takes place when th ...19751221678
childhood urolithiasis in the united kingdom and eire.152 children with urinary calculi were treated in the united kingdom and eire in the years 1972 and 1973. there was a marked male preponderance particularly evident in early life. in 124 children the urine was infected on admission to hospital; in 87, particularly the younger children, this was with the proteus species. awareness of the relationship between proteus urinary infection and matrix calculi is stressed.19751222339
the technique and results of pyleocalycotomy for staghorn calculi.in 10 kidneys treated by the sinus approach the overall recurrence rate was 40%. in 48 kidneys treated by pyelocalycotomy the overall recurrence rate was 17% but only 6% in functioning kidneys with infective stones. infection was controlled in 75% of patients from whom all stone fragments were removed radiologically but all patients in whom fragments remained, or who developed further calculi, remained infected--with proteus in 75% of cases. all patients with kidneys completely cleared of calcul ...19751222341
[antimicrobial effect of carbenicillin combined with prodigiosin and lysozyme in chronic purulent-inflammatory diseases complicated by proteus infection]. 19751223379
antibiotic sensitivity of bacteria from urine.bacteria isolated from the urine of 400 hospital inpatients and 483 outpatients were identified and the in vitro sensitivity of these organisms against 12 antibacterial agents currently used in the treatment of urinary tract infections was determined. there was little difference in the distribution of organisms between the two groups. escherichia coli was predominant, accounting for 58% of the inpatients and 66% of the outpatients. klebsiella was present in 15% of the inpatients as against 7% in ...19751223719
[isolation of mycoplasma from the urine of patients with chronic pyelonephritis].bacteriological analysis of urine of 150 patients with chronic pyelonephritis was performed. as a result mycoplasma was isolated from urine of 25 patients. mycoplasma and coli bacteria or proteus were isolated simultaneously from urine of 10 patients. biochemical properties and sensitivity to antibiotics of 9 isolates were studied. the data provided recommendation of the urine analysis for the presence of mycoplasma.19751225168
[clinical morphological picture of the mucosa of the middle ear in experimental chronic otitis media in rabbits treated with combined antibiotic aerosol preparations].an new method of treating chronic purulent middle otitis with combined aerosol drugs (oxycyclosol, polysol, levovinylsol, vinysol) was developed at the ussr research institute on antibiotics and tested experimentally on 20 shinshilla rabbits. a 0.3 ml volume of microbial suspensition: staphylococcus (group i), ps. aeruginosa (group ii), proteus vulgaris (group iii) and mixed microbial flora (group iv) were administered into the cavities of the middle ear of the rabbits from both sides. the acute ...19751225169
[joint action of nitrofuran preparations and bile acids on bacteria of the genus proteus].sensitivity of 25 fresh isolates of proteus to some nitrofuran drugs most widely used in the clinical practice, such as furacillin, furagin, furazolidone and nitrofurantoin was studied. when the drugs were used in combination with some bile acids, i.e. desoxycholic, dehydrocholic, cholic and glycocholic acids, significant in vitro potentiation of the antibacterial activity of the nitrofurans against the isolates was observed. the combinations of the drugs with desoxycholic acid proved to be most ...19751225184
[modification of the lysine-iron agar (author's transl)].the addition of l-phenylalanine to the lysine-iron agar described by edwards and fife ]1] allows a more valuable screening of the proteus group based on its deamination properties. some minor modifications of the indicator and thiosulfate content lead to improve and earlier recording of the results.19751229984
bacterial urease as a factor in human disease. 19751233112
[septic arthritis in the course of rheumatoid arthritis]. 19751233654
[bacteriological study of the intestinal flora of bats (desmodus rotundus) (author's transl)].stools of 100 bats trapped in the town of anhembi, state os são paulo, brazil, were examined bacteriologically. hemolityc and non hemolytic strains of escherichia coli were found most frequently (29.5%) followed by proteus group (27%) and staphylococcus (20%). from nine samples of stools the authors isolated salmonella typhimurium.19751236052
[a bacteriological study of otitis in dogs (author's transl)].bacteriological examination of 100 cases of otitis in dogs revealed pure cultures of different microorganisms as follows: staphylococcus aureus from 25 animals; escherichia coli from 10; proteus mirabilis from 20; enterobacter sp. from 18 and klepsiella sp. from 7. mixed cultures of proteus mirabilis, pseudomonas aeruginosa and klepsiella sp. were found in 3 animals; staphylococcus aureus and enterobacter sp. in 5; staphylococcus aureus and proteus mirabilis in 4. enterobacter sp. and klepsiella ...19751236059
a proteus inconstans which produces 'cabbage odour' in the spoilage of vacuum-packed sliced bacon. 19751239441
[isolation and characterization of beta-lactamase of proteus rettgeri no. 1602]. 19751240323
microbiological synthesis of l-tryptophan and its related amino acids.crystalline tryptophanase from proteus rettgeri was shown to catalyze the synthesis of l-tryptophan from pyruvate, ammonia and indole, at maximum velocity approaching that of the degradative reaction. based on the results obtained with the crystalline tryptophanase, an enzymatic method for preparation of l-tryptophan and its related amino acids was developed. the cells of proteus rettgeri containing high enzymatic activity were used directly as the enzyme. this method is simple and is one of the ...19751244101
the role of nucleus and cytoplasm in the inheritance of multiplication rates in amoeba proteus cultured at different temperatures. 19761248518
two origins of replication in composite r plasmid dna. 19761250362
a study of the change in dna synthesis of s phase cells treated with n-methyl-n-nitrosourethane: a study using amoeba proteus as a single cell model.the present experiments using amoeba proteus as a single cell model show that dna synthesis continues during and after exposure of s phase cell to n-methyl-n'-nitrosourethane (mnu). at sublethal dose levels which caused long division delays, division and growth abnormalities and mutations, the amount of [3h] thymidine ([3h]tdr) incorporated was decreased by 20-30%; at dose levels which killed all s phase cells it was inhibited by up to 90%. there was a direct correlation between the dose of mnu ...19761253334
a survey of laboratory animal disease in kenya.diseases and infections diagnosed in laboratory mice, rats, guinea-pigs, golden hamsters and rabbits at the veterinary research laboratory, kabete, kenya, are listed and discussed. zoonoses encountered included salmonellosis and lymphocytic choriomeningitis. a number of traditionally recognised conditions were recorded but there were some notable omissions. the changing picture in laboratory animal science in east africa is outlined and attention is drawn to the need for work on related diseases ...19761256011
epidemiologic aspects of nosocomial infections.in a currently ongoing surveillance of hospital-associated infections in two metropolitan hospitals in oklahoma, the results over a four-month period suggest at least tentative principles of host-agent relationships in hospital-associated infections. within the urinary tract, the site with the highest number of total isolations, escherichia coli and klebsiella pneumoniae were the most common pathogens. by age, the under 5 and over 60 year age groups had the highest number of isolations. staphylo ...19761257828
an outbreak of nosocomial proteus rettgeri urinary tract infection.between december 1, 1971, and november 30, 1972, 11 patients on a single physical rehabilitation ward in a large st. louis, missouri, community hospital developed proteus rettgeri urinary tract infections; p. rettgeri isolates from each patient were indole-negative and resistant in vitro to all antibiotics tested. infected patients were more likely to have indwelling urinary tract catheters than were matched control patients, and all had previously received systemic antibiotic therapy. retrospec ...19761258855
microbial flora of the larynx, trachea, and large intestine of the rat after long-term inhalation of 100 per cent oxygen.effects of long-term inhalation of 100 per cent oxygen on the microbial flora of the rat larynx, trachea, and large intestine were studies. rats were kept 14 days in an atmosphere of 100 per cent oxygen after being conditioned to high oxygen concentrations by exposure to three cycles of 100 per cent oxygen (two days) alternating with 40 percent oxygen (two days). controls were kept under similar conditions in normal atmosphere. rats were sacrificed, and at necropsy laryngotracheal swabs and feca ...19761259185
in vitro activity of bl-s640 against gram-negative bacilli and staphylococcus aureus compared with activity of four other semisynthetic cephalosporins.the in vitro activity of bl-s640 (cefatrizine) was determined against 674 recent clinical isolates of staphylococcus aureus and enterobacteriaceae. activity against s. aureus was less than that of cephapirin, cephalothin, and cefazolin, but greater than that of cephalexin. activity against gram-negative isolates was variable: bl-s640 was slightly less potent than cefazolin against escherichia coli and klebsiella, but more active than the other compounds. as for the more resistant gram-negative g ...19761259401
efficacy of cinoxacin in urinary tract infections.cinoxacin, a new synthetic antibacterial agent with in vitro activity against all species of enterobacteriaceae, was used in the treatment of urinary tract infections in 20 patients. the dose of cinoxacin was 250 mg orally every 6 h for 10 days. the etiological agents were escherichia coli in fifteen, klebsiella-enterobacter in five, proteus mirabilis in two, and providencia in one. the minimal inhibitory concentration for these organisms ranged from 2 to 64 mug/ml. eleven of the 20 patients had ...19761259405
comparative study of the in vitro antibacterial activity of cefoxitin, cefuroxine, and cephaloridine.the in vitro antibacterial effects of cefoxitin, a semisynthetic cephamycin, cefuroxime, a new cephalosporin antibiotic, and cephaloridine were compared. with gram-positive bacteria, marked differences were found only in the effects against streptococcus faecalis, where cephaloridine and cefuroxime were superior to cefoxitin. with gram-negative aerobic bacteria, cefoxitin, which is known to be more resistant to beta-lactamases from gram-negative bacteria than any cephalosporin, was found to be m ...19761259406
cefuroxime, a new cephalosporin antibiotic: activity in vitro.cefuroxime is a new broad-spectrum cephalosporin antibiotic with increased stability to beta-lactamases. this stability, although no absolute in all cases, has the effect of widening the antibacterial spectrum of the compound so that many organisms resistant to the established cephalosporins are susceptible to cefuroxime. it is active against gram-positive organisms, including penicillinase-producing staphylococci, but it is less active against methicillin-resistant strains. in addition to its h ...19761259407
studies on changes in the nuclear helices of amoeba proteus during the cell cycle.the fine structure of the nuclei of synchronously growing cell population of amoeba proteus was studied at i-h intervals during the interphase. this study showed that the nuclear helices undergo increases in their number at certain stages during interphase. these changes were found to correlate with ultrastructural changes occurring in the nucleoli.19761262409
graphs of contracting glycerinated amoeba proteus. 19761264207
synergy of mecillinam (fl1060) with penicillins and cephalosporins against proteus and klebsiella, with observations on combinations with other antibiotics and against other bacterial species.thirty-five strains each of klebsiella and proteus were tested for susceptibility to mecillinam alone and in combination with ampicillin, carbenicillin, cephalothin, and cefazolin. antibiotics were considered to be synergistic when there was a >/=fourfold reduction in minimum inhibiting concentration of both antibiotics in the combination as compared with that of each antibiotic alone. synergy of mecillinam with ampicillin, carbenicillin, cephalothin, and cefazolin was demonstrated against 2, 3, ...19761267442
bacteriostatic and bactericidal activity of two trimethoprim-sulfonamide combinations.sulfamoxole (sdmo) has the same half-life of elimination from human plasma as sulfamethoxazole. its antibacterial properties, however, are often inferior to those of co-trimoxazole. its less pronounced antibacterial effect, especially against gram-negative pathogens, also becomes evident in the combination with trimethoprim (tm). the inhibition zones are often smaller around discs containing the same amount of the components sdmo/tm as those with co-trimoxazole and the inhibitory concentrations ...19761269292
blastocystis hominis: pathogenic potential in human patients and in gnotobiotes. 19761269579
inhibition of cell division in amoebae: the incorporation of tritiated precursors into amoeba proteus after the injection of non-homologous cytoplasm.the injection of non-homologous cytoplasm into any strain of large free-living amoebae leads to a 60% inhibition of division amongst recipient cells. when the post-microsomal supernatant fraction of amoeba discoides was injected into a. proteus, this inhibition of division was as high as 95%. the incorporation of tritiated precursors, either [3h]uridine or 3h-amino acids, into these inhibited amoebae was studied at various times after the injection of the inhibitory material using autoradiograph ...19761270528
wound infection following laryngectomy. the effect of topical ampicillin and carbenicillin.a study of twenty-two consecutive laryngectomies performed in one unit is reported. in eleven controls, seven (67%) developed a wound infection. in eleven patients, ig of ampicillin and ig of carbenicillin were used topically, and three (18%) developed a wound infection (p less than 0-04). studies of the bacterial flora at the time of operation suggest that the major source of wound contamination is colonization of the upper gastrointestinal and respiratory tract. the ease with which a small inn ...19761270915
scanning electron microscope observations of amoeba proteus during phagocytosis.phagocytosing amoeba proteus at different stages of forming foodcups have been observed by scanning electron microscopy. a nonphagocytosing ameba is characterized by dorsal and lateral ridges running longitudinally over the posterior half of the cell and its attachment to the substrate over small areas. when stimulated by prey organisms, the ameba loses polarity and ridges, and adheres to the substrate more firmly over a wider area of contact. then it forms broad pseudopods to surround its prey ...19761271309
[gentamicin therapy of infectious diseases by pathogens (author's transl)].gentamicin (gm) was intramuscularly injected to 29 patients with various infections in the doses of 40-60 mg twice a day. the maximum dose was 1,800 mg. satisfactory clinical results were obtained in the treatment of not only urinary tract infections but also respiratory tract infections, bile duct infections and others. this clinical results would coincide with the fact that almost all organisms isolated had a high sensitivity to gm. no significant abnormal findings was observed in this clinica ...19761271580
[concerning the question of the bactericidal action of organic n-bromoamines: experiments with n,n-dibromo-tert.-butylamine (author's transl)].for the first time a defined n-fromoamine was examined on its bactericidal behaviour. in accordance with the "richtlinien für die prüfung chemischer desinfektionsmittel" (3. aufl. stuttgart: gustav fischer verlag 1972), the action of the substance (1,5 x 10(-3) - 1,5 x 10(-5) m aqueous solution) on the germs e. coli, proteus vulgaris, ps. aeruginosa und staph. aureus sg 511 was tested. as can be seen in tab. 1, n,n-dibromo-tert.-butylamine (1,5 x 10(-3) and 1,5 x 10(-4) m/i is showing a bacteric ...19761274501
medical management of urolithiasis.knowledge of the crystalline structure of the calculus provides the basis of the therapeutic plan. laboratory evaluation depends heavily upon routine urinalysis. assessment of renal function, serum calcium, phosphorus, uric acid and, in some cases electrolytes is usually indicated, as is urography. general principles of management include maintenance of an ample urine volume, eradication of infection and correction of any obstructing lesions or metabolic abnormalities. specific antistone regimen ...19761274811
absolute configuration of 3-hydroxy fatty acids present in lipopolysaccharides from various bacterial groups.the absolute configuration of 3-hydroxy fatty acids has been studied, which are present in the lipopolysaccharides of the following bacteria: phodopseudomonas gelatinosa, rh. viridis, rhodospirillum tenue, chromobacterium violaceum, pseudomonas aeruginosa, bordetella pertussis, vibrio metchnikovii, vibrio cholerae, salmonella spp., escherichia coli, shigella flexneri, proteus mirabilis, yersinia enterocolitica and fusobacterium nucleatum. the 3-hydroxy acids were liberated by strong alkaline hyd ...19761278168
[tryptic and chymotryptic activity in the faeces of children of different age groups (author's transl)].measurement of tryptic and chymotryptic activity in the faeces was not disturbed by bacterial proteolytic activity of different bacteria such as proteus, pseudomonas, coli, enterococci, bacteroides. both activities within a group follow a logarithmic normal distribution. lower limit of the standard deviation is 51% upper limit 129% for tryptic activity, respectively 60 and 170% for chymotryptic activity. there were no differences in chymotryptic activity between the 10 age groups comprising 157 ...19761278186
[specific immune preparations for the prevention and treatment of suppurative-inflammatory diseases of proteus etiology (a review of the literature)].literature data are analyzed on the possibility of designing vaccines proteus agents for obtaining specific blood agents. perspective are designs directed to investigation of the raw material base for obtaining allogenous anti-proteus blood agents.19921280887
[the antigenic relationships of morganella].interspecies relationships in the genus morganella have been studied in the agglutination and adsorption tests. new data on the antigenic relationships of o groups o43 and o49 and more precise data on the antigenic relationships of o groups o1 to o42 have been obtained. for the first time the relationships of antigens 40 and 42 with 4, 35 and 31, 38 and 39, 9 and 45, 1a, d and 49; 45 and 47, 24 and 45; 5, 23, 26 with 47; 1, 19, 46 with 41, 48 have been described and the complete identity of o an ...19921281595
[efficiency of inhibitors (phenylethanol, nalidixic acid, sodium azide)in the isolation of strictly anaerobic bacteria from a polymicrobial specimen].the efficacy of inhibitors (pea, ac nal, az de na) in the isolation of strict anaerobes in polymicrobial sample. the efficacy of three inhibitors to select strict anaerobic bacteria in the polymicrobial sample had been studied. first step: the most frequent anaerobes encountered in the infections are isolated in the agar columbia containing the different inhibitors. this step allowed us to check the inhibition of the germ we have to isolate. next step: polymicrobial mixtures were made. the compo ...19921285025
effects of some tricyclic psychopharmacons and structurally related compounds on motility of proteus vulgaris.a simple test for the evaluation of drugs interfering with bacterial motility was established with proteus vulgaris. with this model, promethazine, 7-hydroxy-chlorpromazine, imipramine, 7,8-dioxochlorpromazine and acridine orange were shown to exert significant motility and swarming inhibitory action on proteus vulgaris strains at subinhibitory concentrations. quinidine enhanced the antimotility effect of promethazine. the antimotility effect of promethazine was synergized by proton pump inhibit ...19921285649
aqueous kinetics of sisomicin sulphate.sisomicin sulphate is a new-generation aminoglycoside with a broad spectrum of antimicrobial activity that includes pseudomonas aeruginosa. it is superior to gentamicin against indole-negative proteus and some resistant strains of pseudomonas. the ocular pharmacokinetics of sisomicin have not been explored. we used the agar diffusion technique of microbial assay to determine the aqueous penetration and bioavailability of a subconjunctivally placed standard dose of 20 mg/0.4 ml of sisomicin sulph ...19921286708
leishmania major: bacterial contamination of cutaneous lesions in experimental animals.no bacterial contamination has been demonstrated in cutaneous leishmaniasis (cl) nodule and in lesions caused by leishmania major in balb/c mice up to 20 days after infection. however, although many phagocytic cells (polymorphonuclear leukocytes and macrophages) were present in the cl lesion, 80% of the lesions showed bacterial contamination that developed within the first 70 days of infection. topical treatment of the lesion with an ointment containing 15% paromomycin and 12% methylbenzethonium ...19921286954
[pharmacokinetic and clinical studies on cefprozil granules in the pediatric field].cefprozil (cfpz), a newly developed oral cephalosporin in a fine granular form for pediatric use, was administered to children with bacterial infections. mics were determined for 6 drugs including cfpz, cephalexin (cex), cefaclor (ccl), ampicillin (abpc), methicillin (dmppc) and cloxacillin (mcipc) against the following 84 strains isolated from cases to which cfpz was administered; 55 strains of gram-positive cocci (gpc) including 2 strains of staphylococcus aureus, 49 strains of streptococcus p ...19921289589
[microbicidal effect of lautercide, a new disinfectant].the authors tested the effect of a new disinfectant lautericide produced by qualichem co. neratovice which contains as the active agent acetate amine of coconut acid. for experiments standard methods were used and standard strains for testing of the following microbial strains: st. aureus, e. coli, ps. aeruginosa, proteus vulgaris, serratia marcescens, candida albicans, spores of bacillus subtilis, m. tuberculosis, m. fortuitum, m. avium. as a model virus e. coli bacteriophage ox 174 was used. i ...19921291115
preparation and binding specificity of a monoclonal antibody recognizing 3-deoxy-d-manno-2-octulosonic acid (kdo) in lipopolysaccharides of re chemotype.a mouse monoclonal antibody (mab e1) was raised against the lipopolysaccharide (lps) of the re mutant r595 of salmonella minnesota. this igg3 antibody (mab e1), unstable at low ph and low ionic strength, was purified by chromatography on qae sepharose a50. the binding specificity of mab e1 was characterized by direct and inhibition enzyme immunoassays, using natural lpss from different strains and chemotypes, and synthetic analogs of lps substructure of the 3-deoxy-d-manno-2-octulosonic acid (kd ...19921294455
spectrum and susceptibility of pathogens causing acute uncomplicated lower uti in females and its correlation to bacteriologic outcome after single dose therapy with fosfomycin trometamol versus ofloxacin/co-trimoxazole.in a multicentric study comparing oral single-dose therapy of fosfomycin trometamol (3 g as fosfomycin) versus co-trimoxazole (1.92 g) or ofloxacin (200 mg) as many as possible of the pathogens were sent to and analysed in a central laboratory. the pathogens were identified and minimal inhibitory concentrations (mic) of fosfomycin, trimethoprim alone and in combination with sulfamethoxazole, ofloxacin, ampicillin, amoxicillin combined with clavulanic acid, and cephadroxil were determined. the er ...19921294521
campylobacter jejuni in acute diarrhoea in infancy and its relation to faecal leucocytic count.a prospective study was carried out to identify the relative risk of campylobacter jejuni infection in 50 infants with acute diarrhoea, 24 infants with acute resistant diarrhoea and 25 healthy normal infants as a matching control group. faecal samples were collected from the three groups and were cultured on both selective media for campylobacter and other media for isolation of other organisms. direct stool smears, stained with methylene blue, were examined for detection of faecal leucocyte in ...19921295942
inhibition of salmonella ferlac by enterobacteria under in-vitro conditions.interactions of proteus morganii, proteus mirabilis, proteus sp. klebsiella oxaenae and serratia marcescens isolated from vegetable salads of mass feeding systems with salmonella ferlac (a new subgenus vi of salmonella) isolated from a hostel cook's hands and lizard droppings were recorded following in-vitro nephelometric analysis. nephelometric analysis revealed inhibition of s. ferlac by all the tested isolates from fifth hour of mixed culture interaction. k. oxaenae was the strong inhibitor.19921296949
[role of bacterial metabolism in transformation of non-mutagenic compounds into mutagens. ii. participation of bacteria producing urease in degradation of pesticides--urea derivatives].participation of bacteria producing urease: proteus mirabilis and staphylococcus epidermidis in degradation of pesticides--urea derivatives, was investigated. four new compounds were studies: n-/(3-trifluoromethyl)phenyl/n'-(2-cyanoethyl)-urea (ipo 6584), n-(4-chlorophenyl)-n'-(2-hydroxyethyl)-n'-ethylurea (po 6236), n-(4-chlorophenyl)-n'-(2-hydroxyethyl), n'-propyl-urea (ipo 6237), n-(2-hydroxyethyl), n-methyl-n'-(3,4 dichlorophenyl)-urea (ipo 3102), pesticide reference standard--thiram fungici ...19921297032
[comparative in vitro susceptibility of clinical bacterial isolates to pefloxacin and 14 antibiotics].in vitro activity of pefloxacin against 782 bacterial strains isolated from hospitalized patients (july-september 1991) in wrocław was compared with that of 14 antibiotics (4 aminoglycosides and 10 beta-lactamase). the most susceptible to pefloxacin were: staphylococcus epidermidis (96.0%), klebsiella (94.4%), proteus mirabilis (93.8%) and escherichia coli (92.7%). the least susceptible proved to be: nonfermentative gram-negative rods (46.5%), and among them pseudomonas aeruginosa (19.3% weakly ...19921297147
bacteriuria in patients with glomerular diseases.in a comparative study of significant bacteriuria in an african population, 1.7% of 697 healthy subjects (10 females and 2 males) were found to have positive urine cultures. of these, 5 subjects grew e. coli, 4 klebsiella strains, 2 staphylococcus aureus and 1 serratia marcescens. among 116 patients with glomerular disease, 15.5% (7 males and 11 females) yielded positive cultures. e. coli, staph. aureus and proteus species were commonly isolated organisms. there was a nine fold increase in preva ...19921298612
[urinary tract infections at the hospital and the ambulatory service: etiology and laboratory diagnosis].an aetiology study was conducted into urinary tract infections (uti) in order to compare hospital infections with those in outpatients identified from samples sent to the laboratory by general practitioners. urine culture analysis was performed on 3,483 samples of which 740 came from hospital patients and 2,743 from outpatients. the diagnosis of uti was based on new criteria: not only the assessment of bacterial proliferation but also clinical factors like sex, symptoms, sampling technique and u ...19921299002
[cytofluorimetric research on the changes in the dna content in the nuclei of amoeba proteus during prolonged starvation and after refeeding].dividing amoebae were manually selected from the culture of amoeba proteus, and so groups of synchronously dividing (synchronized) amoebae were obtained. these synchronized amoebae were maintained without food. in spite of starvation, individual amoebae in some particular groups were seen to divide, whereas in other groups of amoebae there was no division at all. the starving amoebae died not earlier than 2 weeks after the last division. a relative dna content in isolated nuclei has been determi ...19921302398
[comparative effectiveness of antimicrobial action of antiseptics against pathogens of chronic purulent otitis media].comparable antimicrobial and disinfecting action of decamethoxine and silver preparations on pathogens of chronic purulent otitis media (cpom) was studied. the clinical isolates of staphylococci proved to be most sensitive to decamethoxine whose mbcc conformed to 16.5 micrograms/ml. the antimicrobial action on proteus spp. and pseudomonas aeruginosa was less pronounced. the required concentrations for bactericidal action on these pathogens were 69 and 93.5 micrograms/ml, respectively. the antimi ...19921304133
percutaneous debridement of complex pyogenic liver abscesses.the author's approach and technique in the treatment of complex liver abscesses that persisted or recurred following percutaneous drainage are described. six patients were treated by percutaneous debridement using an instrument specially designed for that purpose. four patients were chronically ill but stable, while the other two were septic, hypotensive and considered to be life threatened. all patients had primary pyogenic abscesses. four had demonstrated mixed bacterial flora consisting of e. ...19921304464
antimicrobial resistance: patterns and trends in the national university hospital, singapore (1989-1991).the commonly isolated organisms, staphylococcus aureus, escherichia coli, klebsiella species, pseudomonas aeruginosa, acinetobacter species, proteus species and enterobacter species from clinical material other than blood, cerebrospinal fluid and stool, were analysed for their incidence and increasing trends of resistance to the commonly used antimicrobials. staphylococcus aureus was tested against penicillin, methicillin, erythromycin, gentamicin and co-trimoxazole; pseudomonas aeruginosa again ...19921304631
antimicrobial resistance of 100 serial gram-negative isolates in two intensive care units.to determine antimicrobial resistance pattern among gram-negative bacteria isolated from suspected sources of infections in patients hospitalized in two intensive care units (icus) at siriraj hospital from september 1991 to december 1991, minimal inhibitory concentrations of one-hundred consecutive gram-negative isolates for various antimicrobials were performed using the microbroth dilution method. of all gram-negative bacterial isolates, 25 per cent were pseudomonas aeruginosa, 22 per cent aci ...19921308536
[comparative activities in vitro of 4 quinolones (nalidixic acid, pefloxacin, norfloxacin, ofloxacin) on 13 bacterial species].nalidixic acid and three fluoroquinolones were tested on 389 strains belonging to 13 bacterial species, all isolated in algeria. ofloxacin, norfloxacin and pefloxacin have the same activities on e. coli, acinetobacter and s. aureus. norfloxacin has the best activity on proteus, enterobacter, shigella and klebsiella. norfloxacin and ofloxacin have the same activities on s. typhi, salmonella and choleric vibrio. norfloxacin has the same activity than pefloxacin on p. aeruginosa. it is necessary to ...19921309146
detection of ciprofloxacin resistance in gram-negative bacteria due to alterations in gyra.two plasmids containing the cloned escherichia coli wild-type gyra gene were used to transform ciprofloxacin-resistant gram-negative clinical isolates to screen for dna gyrase a-mediated quinolone resistance. the results show that the technique is simple and applicable to a wide range of gram-negative species including e. coli, enterobacter cloacae, klebsiella aerogenes, morganella morganii, proteus mirabilis, pseudomonas aeruginosa, campylobacter jejuni and neisseria gonorrhoeae. the use of an ...19921310671
comparison of three-day temafloxacin with seven-day ciprofloxacin treatment of urinary tract infections in women.temafloxacin is a new broad-spectrum arylfluoroquinolone antimicrobial with an extended serum half-life.19921310715
comparison of the safety and efficacy of lomefloxacin and trimethoprim/sulfamethoxazole in the treatment of uncomplicated urinary tract infections: results from a multicenter study.lomefloxacin, a new difluorinated quinolone, and trimethoprim/sulfamethoxazole (tmp/smx) were compared in the treatment of adults with uncomplicated urinary tract infections. the study was conducted as a multicenter, controlled, prospectively randomized, single-blind study in five countries (argentina, belgium, brazil, mexico, and venezuela). a total of 254 patients were enrolled: 129 in the lomefloxacin group and 125 in the tmp/smx group. patients received either 400 mg lomefloxacin orally once ...19921316074
myeloperoxidase-enhanced formation of (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene-dna adducts in lung tissue in vitro: a role of pulmonary inflammation in the bioactivation of a procarcinogen.several studies have indicated a correlation between the presence of inflammation and the development of cancer. the aim of our study was to determine if pulmonary neutrophils could transform the proximate respiratory carcinogen (+-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (b[a]p-7,8-diol), to an ultimate carcinogenic metabolite via myeloperoxidase (mpo). to test this hypothesis, virus-free male dba/2 mice were exposed by inhalation to the gram-negative bacteria proteus mirabilis for 1 h. ...19921322250
[microbial ecology of the digestive tract in patients with acute intestinal infections]. 19921324548
proteus syndrome: report of the first japanese case with special reference to differentiation from klippel-trenaunay-weber syndrome.this is the first report of a japanese girl with proteus syndrome. she presented with growth acceleration and precocious development of the left breast as well as macrodactyly, hemihypertrophy, a subcutaneous preaxillary mass, portwine stains, connective tissue nevi, and a depigmented macule. all these abnormalities were confined to the left side of her body. although most of the manifestations fit those of proteus syndrome, the presence of the portwine stains and hemihypertrophy also suggested ...19921328340
in vitro antibacterial activities of tosufloxacin against and uptake of tosufloxacin by outer membrane mutants of escherichia coli, proteus mirabilis, and salmonella typhimurium.the antibacterial activities of tosufloxacin and other quinolones against and apparent uptakes of tosufloxacin and other quinolones by outer membrane mutants of escherichia coli, proteus mirabilis, and salmonella typhimurium were studied. the hydrophobicity of tosufloxacin was nearly equal to that of ofloxacin or lower than those of sparfloxacin and nalidixic acid. ompf- and ompc-deficient e. coli and 40-kda porin-deficient p. mirabilis mutants were twofold more susceptible to tosufloxacin and s ...19921329639
inhibition of motility of pseudomonas aeruginosa and proteus mirabilis by subinhibitory concentrations of azithromycin.exposure to subinhibitory concentrations (4-8 micrograms/ml) of azithromycin resulted in loss of motility in proteus mirabilis strains and a significant reduction of motility in pseudomonas aeruginosa strains. examination revealed that the loss of motility was due to a total absence of flagella in proteus mirabilis while the poor motility observed in pseudomonas aeruginosa was due to absence of flagella in the majority of the population. since motility may be considered a pathogenicity trait in ...19921330564
resistance to amoxicillin/clavulanate in escherichia coli. 19921334325
[annual changes of bacteria isolated from urinary tract infections and their susceptibility to new quinolone agents].statistical analyses were conducted on bacterial strains isolated from the urine of patients with urinary tract infections (uti) in the department of urology at aichi medical university from january 1988 through december 1991. the drug sensitivity of the bacterial strains isolated from patients with complicated uti between 1988 and 1991 was analyzed and compared. among the outpatients with uncomplicated uti, a total of 352 strains were isolated. e. coli was isolated the most frequently (90.1%). ...19921336639
molecular epidemiology of endemic ciprofloxacin-susceptible and -resistant enterobacteriaceae.to elucidate the epidemiology of widespread ciprofloxacin resistance in our veterans affairs medical center using whole cell dna analysis.19921337751
susceptibility of recent clinical isolates to temafloxacin (a-63004) and other antimicrobial agents.in vitro susceptibility of 1008 strains of recent clinical isolates was determined against the new aryl fluoroquinolone temafloxacin (t-167, a-63004) ciprofloxacin, norfloxacin, ampicillin, piperacillin, cephalothin, cefoxitin, ceftazidime, gentamicin, amikacin, oxacillin and vancomycin. the minimum inhibitory concentrations (mics) of temafloxacin in micrograms/ml required for > or = 90% isolates were 0.13-0.5 for enterobacter, 0.03-0.25 for escherichia coli, 0.12-0.5 for klebsiella, 0.5-1.0 for ...19921338041
[proteus syndrome. expansion of the phenotype. apropos of 3 pediatric cases].in 1979 cohen et hayden and in 1983 wiedemann et al. delineated a syndrome consisting of partial gigantism of the hands and/or feet, nevi, hemihypertrophy, subcutaneous tumors, macrocephaly or other skull anomalies and possible accelerated growth and visceral affections. hitherto the literature pertaining to this syndrome consists of somewhat more than 100 cases of which some, that have been described previously or subsequently under other headings, were rediagnosed as being proteus syndromes. o ...19921338804
[mastoiditis--a forgotten disease?].the symptoms and clinical course of latent mastoiditis in 18. children treated in polish-american children's hospital in cracow were presented. the ultimate diagnosis of mastoiditis was based on typical findings on antrotomy and the presence of granulation on histology of the tissue obtained during the operation. the main symptoms of latent mastoiditis were: a lack of appetite, chronic or recurrent fever and failure to thrive. 11 children (61%) had experienced more than 3 episodes of acute otiti ...19921341758
in vitro antibacterial activities of ticarcillin alone and ticarcillin plus clavulanic acid against beta-lactamase producing and non-producing microorganisms.a total of 818 clinical bacterial isolates were tested for the production of beta-lactamase by rapid chromogenic cephalosporin method and for the susceptibility to ticarcillin alone and in combination with clavulanic acid (2 micrograms/ml) by agar dilution method. these included 83 strains of methicillin-sensitive staphylococcus aureus (mssa), 31 of methicillin-resistant s. aureus (mrsa), 49 of neisseria gonorrhoeae, 58 of haemophilus influenzae, 112 of escherichia coli, 118 of klebsiella pneumo ...19921342000
the reactivity between rickettsiae and weil-felix test antigens against sera of rickettsial disease patients.of the sera which were positive to rickettsia tsutsugamushi by indirect immunoperoxidase test, approximately 80% sera were positive to a proteus oxk antigen by weil-felix test at 10 or more days after the onset of fever, while only 10% sera were positive within 9 days from the onset of fever. in elisa using the oxk antigen, almost all of the paired sera of tsutsugamushi disease (td) patients increased on the igm antibody titres with the rise of their titres by weil-felix test, whereas the igg an ...19921350175
epidemiological role of arthropods detectable in health facilities.a total of 161 arthropod specimens were collected from 55 sites in a health care facility during july and september 1990. of the 116 bacterial isolates obtained from their body surfaces 6% were from parasites (mosquitoes), 59% from eusynanthropic arthropods (tenebrionid beetles, flies, german cockroaches, wasps), 16% from hemisynanthropic arthropods (ants, spiders) and 19% from occasionally encountered insects (non-biting midges, moths, beetles). most (88%) of the isolated bacteria were gram-neg ...19921350604
microbiology of postoperative wound infection: a prospective study of 1770 wounds.a prospective study of postoperative wound infection was carried out over a 12-month period. intra-operative swabs from the patients' anterior nares, the opened viscus and parietes were cultured using standard bacteriological techniques. of the 1770 wounds studied, 167 (9.4%) became infected. wound infection rates, according to clinical wound types, were clean 5.9%, clean-contaminated 10.7%, contaminated 24.3% and dirty 52.9%. the figures according to microbiological wound types were clean 4.7%, ...19921351494
a novel electrical method for the prevention of microbial colonization of intravascular cannulae.an electrical device designed to prevent microbial attachment to plastic intravascular cannulae is described. the device produced an electrical current (10 microa) in both carbon-impregnated and 'hydrocath' cannulae. in-vitro models were utilized to demonstrate that the current can block several mechanisms by which microorganisms gain initial access to intravascular devices, including extra- and intra-luminal routes. the electrical system prevented organisms from traversing along both the extern ...19921358949
pyrizinostatin: a new inhibitor of pyroglutamyl peptidase. 19921361487
imipenem versus netilmicin and vancomycin in the treatment of capd peritonitis.imipenem/cilastatin is a new thienamycin antibiotic with a broad bactericidal spectrum. we undertook a prospective randomised study to compare the safety and efficacy of intraperitoneal (ip) imipenem/cilastatin (2 gm daily) [group a; 21 patients, mean age 49.2 years] with a combination of ip netilmicin and vancomycin (500 and 60-100 mg daily resp.) [group b; 20 patients, mean age 55.2 years] in capd peritonitis. each patient underwent 4 daily capd exchanges with antibiotics in alternate exchange ...19921361795
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