| anaphylaxis in guinea-pig peripheral airways in vitro. | the contributions made by histamine, prostaglandins (pg) and slow reacting substance (srs-a) to anaphylactic contractions in isolated guinea-pig lung were investigated. histamine, pgf2alpha and srs-a induced isometric contractions in lung parenchymal strips and in tracheal smooth muscle. the effective concentrations of the autacoids were the same in lung strips and tracheas. anaphylactic contractions in lung strips from bovine serum albumin sensitised animals were not affected by mepyramine (5 x ... | 1979 | 421743 |
| [antibacterial activities of sisomicin against fresh clinical isolates]. | to investigate antibacterial activities of sisomicin (siso), mics of siso as well as other aminoglycosides (ags) were determined against many clinical isolates which were obtained in 1991. results are summarized below: 1. no siso-resistant strains were observed among isolates of escherichia coli, citrobacter diversus, klebsiella pneumoniae, klebsiella oxytoca, enterobacter aerogenes, proteus mirabilis and morganella morganii. 2. in comparison with the results of our previous study against isolat ... | 1992 | 1433905 |
| analysis of polar lipids from some representative enterobacteria, plesiomonas and acinetobacter by fast atom bombardment-mass spectrometry. | fast atom bombardment-mass spectrometry (fab-ms) was used to analyse lipid extracts of bacteria to assess its usefulness for analysing anionic phospholipids of potential chemotaxonomic value. the following micro-organisms were tested: acinetobacter calcoaceticus, acinetobacter sp., citrobacter freundii, enterobacter cloacae (2 strains), escherichia coli (3 strains), hafnia alvei, klebsiella oxytoca, klebsiella pneumoniae, morganella morganii, plesiomonas shigelloides, proteus mirabilis (3 strain ... | 1992 | 1447059 |
| identification of amino acid changes affecting yeast uroporphyrinogen decarboxylase activity by sequence analysis of hem12 mutant alleles. | the molecular basis of the uroporphyrinogen decarboxylase defect in eleven yeast 'uroporphyric' mutants was investigated. uroporphyrinogen decarboxylase, an enzyme of the haem-biosynthetic pathway, catalyses the decarboxylation of uroporphyrinogen to coproporphyrinogen and is encoded by the hem12 gene in the yeast saccharomyces cerevisiae. the mutations were identified by sequencing the mutant hem12 alleles amplified in vitro from genomic dna extracted from the mutant strains. four mutations lea ... | 1992 | 1471989 |
| narrow-band sound localization related to external ear acoustics. | human subjects localized brief 1/6-oct bandpassed noise bursts that were centered at 6, 8, 10, and 12 khz. all testing was done under binaural conditions. the horizontal component of subjects' responses was accurate, comparable to that for broadband localization, but the vertical and front/back components exhibited systematic errors. specifically, responses tended to cluster within restricted ranges that were specific for each center frequency. the directional transfer functions of the subjects' ... | 1992 | 1479124 |
| [the inhibitory effect of some antibiotics upon histamine production and growth of proteus morganii. gentamycin, tetracycline, penicillin, streptomycin and combination of penicillin with streptomycin (author's transl)]. | | 1975 | 1074032 |
| avoidance of endotoxin-induced inflammation during studies of albumin clearance from caprine joints. | intra-articular injection of radiolabelled, commercial goat serum albumin (gsa) produces acute arthritis in caprine joints. this inflammation distorts clearance values and vitiates studies of normal lymphatic function. endotoxin, routinely found in commercial albumin preparations, appears to cause this local reaction. we describe a simple method for the preparation of low-endotoxin, radioiodinated serum albumin from aseptically collected serum. we have used this technique to prepare gsa for use ... | 1992 | 1489542 |
| survey of the prevalence of beta-lactamases amongst 1000 gram-negative bacilli isolated consecutively at the royal london hospital. | beta-lactamase expression was examined in 1000 consecutive gram-negative bacilli isolated from urine, wound swab, sputum or blood specimens received at the microbiology laboratory of the royal london hospital. this survey, performed between january and april, 1991, followed a similar study undertaken in early 1982. the distribution of species was similar in the two surveys, except that the proportion of pseudomonas aeruginosa isolates had increased from 11% in 1982 to 17.5% in the present study. ... | 1992 | 1490917 |
| [antimicrobial activities of ceftazidime on fresh clinical isolates]. | antimicrobial activity of ceftazidime (caz) was compared with those of other cephem antibiotics against clinically isolated strains sent to us by medical institutions throughout japan in 1989 and 1991. those strains separated and identified from samples collected from patients with various infections were also examined, and the following results were obtained. 1. the results suggested that, compared with reports of studies conducted with clinical isolates in early 1980's, mic90 of caz in 1991 we ... | 1992 | 1494227 |
| effect of x-irradiation on 3-h-glucosamine uptake by human embryo fibroblasts. | the incorporation of 3-h-glucosamine into unirradiated and x-irradiated (905 rad) cultures of human embryo fibroblasts was studied by light microscopic, autoradiographic and biochemical methods in pulse-chase experiments. the precursor was 3-h-glucosamine. in unirradiated cells the grains appeared in various subcellular regions in a particular order: at first over the golgi complex, then over the whole cytoplasm and finally at least some of the labelled macromolecules emerged from the cell. the ... | 1975 | 1079795 |
| enterococcus hirae in septicaemia of psittacine birds. | | 1992 | 1496756 |
| in vitro activity and beta-lactamase stability of ljc 10,627. | the in vitro activity of ljc 10,627, a new carbapenem, was compared with those of imipenem, cefotaxime, ceftazidime, and gentamicin. ljc 10,627 inhibited 90% of escherichia coli, klebsiella pneumoniae, klebsiella oxytoca, enterobacter aerogenes, enterobacter agglomerans, enterobacter cloacae, hafnia alvei, citrobacter freundii, citrobacter diversus, proteus mirabilis, morganella morganii, proteus rettgeri, serratia marcescens, pseudomonas cepacia, salmonellae, shigellae, aeromonas, and yersiniae ... | 1992 | 1510436 |
| [antimicrobial activities of ceftriaxone against clinically isolated strains]. | antibiotic activities (mics) of ceftriaxone (ctrx) against 1,210 strains of bacteria including 28 spp. isolated in 1987 and 1990 were compared with those of other cephems. 1. when compared to data on clinically isolated strains reported in the early 1980s, strains of the following species isolated in 1990 showed extremely elevated mic90s of ctrx: staphylococcus spp., streptococcus pneumoniae, escherichia coli, citrobacter spp., enterobacter spp., serratia spp., proteus vulgaris, morganella morga ... | 1992 | 1522669 |
| in vitro activity of cefodizime. | cefodizime is a bactericidal cephem with the typical broad spectrum activity of an aminothiazolyl cephalosporin, including both gram-positive and gram-negative bacteria: its mic90 is 0.125 mg/l for streptococcus pneumoniae, streptococcus pyogenes and other streptococci; and 0.05 mg/l for haemophilus spp., neisseria meningitidis, neisseria gonorrhoeae and moraxella catarrhalis; while beta-lactamase positive strains of m. catarrhalis require 1 mg/l. less than 1 mg/l is needed for escherichia coli, ... | 1992 | 1526673 |
| histogenesis of bile duct-like cells proliferating during ethionine hepatocarcinogenesis. evidence for a biliary epithelial nature of oval cells. | the origin of bile duct-like cells (oval cells) proliferating during chemical hepatocarcinogenesis is highly controversial. to illuminate this issue, we induced oval cell proliferation by feeding rats a choline-devoid diet containing 0.1% ethionine (cde), a hepatocarcinogenic diet, for up to 60 days. at various times we studied 1) oval cell morphology by light and electron microscopy, 2) the immunohistochemical expression of albumin and intermediate filament proteins by the various hepatic cells ... | 1992 | 1538592 |
| pharmacokinetics and pharmacodynamics of subcutaneously administered u40 and u100 formulations of regular human insulin. | action profiles of 12 u of regular human insulin (actrapid hm) administered subcutaneously as a u40 or u100 formulation were studied. euglycaemic glucose clamps were performed on two separate days in 8 healthy subjects (basal i.v. insulin infusion 0.1 mu/kg/min, plasma glucose 5.0 mmol/l, mean +/- sd age 25 +/- 2 years, bmi 22.7 +/- 1.4 kg/m2). serum insulin concentrations increased after injection of u40 or u100 from similar baseline values to maximal individual concentrations of 305 +/- 79 vs. ... | 1992 | 1563532 |
| transient bacteremia associated with barium enema. | a group of 175 patients had barium enema. pour-plate blood cultures were obtained immediately before and after the procedure and 5, 10, 15, and 30 minutes later. bacteremia was demonstrable in 20 (11.4%) patients. in some, blood cultures were positive for as long as 15 minutes after barium enema; all were negative at 30 minutes. among the bacteria associated with the 20 episodes of bacteremia were escherichia coli, klebsiella, enterococci, proteus morganii, bacteroides, and veillonella. the inci ... | 1975 | 1093504 |
| transforming growth factor beta induces myoblast differentiation in the presence of mitogens. | transforming growth factor beta 1 (tgf-beta 1) added to l6e9 rat skeletal myoblasts in mitogen-rich medium induces a rapid decrease in c-myc expression and delays progression through the g1 phase of the cell cycle. this growth inhibitory response is followed by cell commitment to terminal differentiation with elevated expression of myogenin muscle determination genes, induction of muscle-specific proteins, and formation of multinucleated myotubes. these results suggest that tgf-beta 1 may act as ... | 1992 | 1594628 |
| wild running elicited by microinjections of bicuculline or morphine into the inferior colliculus of rats: lack of effect of periaqueductal gray lesions. | bicuculline methiodide, a gabaa receptor antagonist, or a high dose of morphine was injected at the same site within the inferior colliculus (ic) of rats. both drugs elicited the same behavioral activity (wild running). however, the time course and magnitude of the effects of the two drugs differed. since the behavioral activation elicited was reminiscent of what was found with microinjections of bicuculline methiodide or morphine into the periaqueductal gray (pag), we lesioned the pag in anothe ... | 1992 | 1594640 |
| daily rhythmicity of the rat acoustic startle response. | we have measured the acoustic startle response (asr) amplitude and latency in rats housed in a 12:12 light:dark (ld) cycle. the response amplitudes to eliciting stimuli (es) of 110 db or 120 db (white noise) were significantly higher (nearly two-fold) during d than during l. similar, but nonsignificant, trends were also observed at es intensities of 90 db or 100 db. while some significant ld asr latency differences were observed, we cannot ascribe them to the photoperiodic phase at this time. th ... | 1992 | 1594689 |
| purification of recombinant helicobacter pylori urease apoenzyme encoded by urea and ureb. | helicobacter pylori, a gram-negative, microaerophilic, spiral-shaped bacterium, is an etiologic agent of human gastritis and peptic ulceration and is highly restricted to the gastric mucosa of humans. urease, synthesized at up to 6% of the soluble cell protein, hydrolyzes urea, thereby releasing ammonia, which may neutralize acid, allowing survival of the bacterium and initial colonization of the gastric mucosa. the urease protein is encoded by two subunit genes, urea and ureb; however, accessor ... | 1992 | 1612735 |
| the morphology of serotonin-induced renal lesions in the rat. | the progress of serotonin-induced renal lesions was studied over a period of 6 mth following a single intraperioneal injection of 40 mg/kg serotonin. the predominant lesion was ischaemic necrosis of tubules of patchy distribution. parahilar areas were usually spared and a narrow subcapsular strip was less severely affected than deeper parts. the early tubular lesions appeared to be an accelerated form of the lesion of complete renal ischaemia. the necrotic tubules were soon relined by epithelium ... | 1979 | 521864 |
| proceedings: effects of histamine, 2-methylhistamine and 4-methylhistamine on blood pressure and vascular resistance in the cat. | | 1975 | 1151865 |
| in-vitro evaluation of ampicillin/brobactam and comparison with other beta-lactam antibiotics. | the ability of brobactam to inhibit beta-lactamases and the in vitro activity of ampicillin combined with brobactam was compared with another beta-lactamase inhibitor, clavulanic acid, and other beta-lactam antibiotics. both inhibitors showed good and similar activity against staphylococcal penicillinase and most broad-spectrum beta-lactamases found in the enterobacteriaceae, whether plasmid or chromosomally mediated. both inhibitors were less active against chromosomally mediated cephalosporina ... | 1991 | 1646779 |
| in vitro activity and stability against novel beta-lactamases of investigational beta-lactams (cefepime, cefpirome, flomoxef, sce2787 and piperacillin plus tazobactam) in comparison with established compounds (cefotaxime, latamoxef and piperacillin). | the therapeutic perspectives of flomoxef, sce 2787, cefpirome, cefepime, latamoxef, cefotaxime and of piperacillin plus tazobactam were comparatively evaluated by their in vitro activity against 1119 clinical isolates of 83 bacterial species. escherichia coli, klebsiella spp. enterobacter sakazakii, proteus spp. and shigella spp. were about equally susceptible to the cephalosporins (mic90: 0.06 to 0.5 mg/l), while the mic90 for piperacillin plus tazobactam was between 2 and 16 mg/l. enterobacter ... | 1991 | 1664418 |
| antimicrobial activities of piperacillin alone and in combination with tazobactam against beta-lactamase-producing bacteria. | tazobactam (ytr 830), a new beta-lactamase inhibitor, was evaluated for its effect in combination with piperacillin, a broad spectrum, but beta-lactamase sensitive, penicillin, against 14 common bacteria. a total of 1,086 clinical isolates from different clinical specimens were tested for beta-lactamase production by the rapid chromogenic cephalosporin method. their susceptibilities to piperacillin alone and in combination with tazobactam in a ratio of 8:1 by the agar dilution method were evalua ... | 1991 | 1685175 |
| hlyb-dependent secretion of hemolysin by uropathogenic escherichia coli requires conserved sequences flanking the chromosomal hly determinant. | the synthesis and secretion of hemolysin (hlya) by escherichia coli are governed by four contiguous genes (hlycabd) that are closely conserved on plasmids and, among human pathogenic strains, on the chromosome. we have previously shown that in plasmid phly152 the coexpressed synthesis and export functions are uncoupled by intraoperon transcription termination, which is in turn alleviated by antitermination dictated in cis by a region upstream of the hly operon. in this study we describe an analo ... | 1990 | 1689714 |
| monoclonal antibodies to quebec strain (q17) of bovine rotavirus. | fourteen monoclonal antibodies (mabs) against "quebec" strain (q17) of bovine rotavirus were isolated and characterized. four were specific for viral protein vp7 and ten were specific for viral protein vp6. five different isotypes were represented by this group of antibodies. all of the anti-vp6 and none of the anti-vp7 antibodies were sensitive to the effects of periodate on their antigen. the antibodies could be separated into three groups based on their relative resistance to the dissociation ... | 1990 | 1698323 |
| [a case of parieto-pulmonary acquired shunt presenting with hemoptysis (author's transl)]. | the authors report the case of a 52 year old man with arteriovenous shunt developing from the 7th left intercostal artery, revealed by hemoptysis and proved by intercostal selective arteriography. the patient had a past history of serofibrinous pleurity 29 years previously and had undergone paracentesis at this level. the origin of this shunt is then discussed. | 1975 | 1151917 |
| new serotypes of morganella morganii. | on the basis of 8 new o and 11 new h antigens determined in 22 strains, the morganella morganii antigenic schema was supplemented with 8 serogroups (o35-o42) and 13 serotypes. four strains belonged to o groups described earlier and 2 strains contained new o antigens in combination with known o antigens. known h antigens were present in one strain as a single factor and in one strain as combination of two factors. new h antigens were demonstrated in 5 serotypes in combination with known h antigen ... | 1975 | 1155231 |
| isolation and characterization of a lactose-positive strain of proteus morganii. | the characterization of a lactose-positive proteus morganii is presented. the increased incidence of such atypical microorganisms emphasizes the need for a thorough examination of escherichia coli-like colonies by clinical microbiologists. | 1975 | 1176589 |
| relaxant response of isolated basilar arteries to calcitonin gene-related peptide in stroke-prone spontaneously hypertensive rats. | the relaxant effects of calcitonin gene-related peptide (cgrp) and other drugs were compared in basilar artery rings obtained from stroke-prone spontaneously hypertensive rats (shrsp) and wistar-kyoto rats (wky). in addition, the relaxant effect of cgrp on basilar arteries from spontaneously hypertensive rats (shr) was examined. relaxation induced by cgrp was independent of the presence of endothelium, and it was markedly increased in shrsp when compared to wky. in contrast, acetylcholine-induce ... | 1992 | 1279255 |
| [diagnosis and therapy of viral hepatitis]. | | 1991 | 1713243 |
| inhibition of salmonella ferlac by enterobacteria under in-vitro conditions. | interactions of proteus morganii, proteus mirabilis, proteus sp. klebsiella oxaenae and serratia marcescens isolated from vegetable salads of mass feeding systems with salmonella ferlac (a new subgenus vi of salmonella) isolated from a hostel cook's hands and lizard droppings were recorded following in-vitro nephelometric analysis. nephelometric analysis revealed inhibition of s. ferlac by all the tested isolates from fifth hour of mixed culture interaction. k. oxaenae was the strong inhibitor. | 1992 | 1296949 |
| microbiological evaluation of cefpodoxime proxetil. | cefpodoxime, the active de-esterified molecule of the orally absorbable cephalosporin cefpodoxime proxetil, inhibits streptococci, neisseria spp., and most enterobacteriaceae, with mic50 and/or mic90 values of less than or equal to 2 mg/l; with regard to the latter family of bacteria, the mic50 and/or mic90 values of cefpodoxime are consistently greater than or equal to 4 mg/l for only enterobacter cloacae, citrobacter freundii, serratia marcescens, and morganella morganii. the mic50 of cedpodox ... | 1991 | 1726210 |
| in vitro activity of the novel cephalosporin gr69153. | the in vitro activity of gr69153 was compared to that of ceftazidime, ceftriaxone, imipenem and gentamicin against a total of 702 recent clinical isolates. mics were determined by a standard agar dilution procedure and two inocula (10(4) and 10(8) cfu) were used throughout. gr69153 inhibited 90% of isolates of escherichia coli, klebsiella pneumonia and proteus mirabilis at less than or equal to 0.25 mg/l and 90% of isolates of pseudomonas aeruginosa at less than or equal to 1 mg/l. citrobacter f ... | 1991 | 1748126 |
| comparative study of pharmacokinetics and serum bactericidal activity of ceftizoxime and cefotaxime. | single 2-g intravenous doses of ceftizoxime (czx) and cefotaxime (ctx) were given over 30 min to 10 adult volunteers in a crossover manner on two separate occasions. concentrations of czx, ctx, and the primary metabolite of ctx, desacetylcefotaxime (dctx), in serum, suction-induced-blister fluid, and urine were determined by high-pressure liquid chromatography. pharmacokinetic parameters were estimated by using an extended least-squares modeling program (mkmodel). czx exhibited a half-life in se ... | 1991 | 1759827 |
| [plasmid determined lactose positive character in (enterobacter hafniae) and (proteus morganii) (author's transl)]. | the atypical lactose positive characters have been found to be plasmidmediated in 6 strains of enterobacter hafniae and 2 strains of proteus morganii. one of the p. morganii plasmid possesses the fi+ character, all the other plasmids belonging to the fi-group. both plasmids of p. morganii could be transduced and remained then readily transferably by conjugation. two of the e. hafniae plasmids were found unstable when harboured in salmonella typhi grown at 40 degrees centigrade, when they were st ... | 1976 | 786102 |
| enterobacteriaceae in the jejunal microflora prevalence and relationship to biochemical and histological evaluations in healthy colombian men. | when 23 healthy native southwestern colombian men were studied to determine the prevalence of enterobacteriaceae in the jejunal microflora in a sample of thoroughly evaluated tropical inhabitants who were normal by physical examination, chest x-ray, and medical history, 14 of the 23 proved to be enterobacteriaceae-positive, with counts of 10(3) to 10(9) per milliliter of jejunal aspirate. thirteen had escherichia coli, and the fourteenth had klebsiella pneumoniae. four had a second species of en ... | 1976 | 793372 |
| laboratory studies with cefatrizine (sk + f 60771), a new broad-spectrum orally-active cephalosporin. | cefatrizine (sk&f 60771), a new orally-active semisynthetic cephalosporin antibiotic with broad-spectrum antibacterial activity, was compared with cephalexin and cefazolin for in vitro and in vivo antibacterial activity and pharmacokinetic behavior in laboratory animals. the average mic values obtained with cefatrizine against gram-positive and gram-negative bacteria were superior to those obtained with cephalexin and somewhat poorer than those of cefazolin. in addition, a large percentage of th ... | 1975 | 808525 |
| a review of 105 necropsies in captive baboons (papio cynocephalus). | in contrast to the findings in newly caught babboons in africa, the leading cause of death in captivity in america was a pneumonia and enteritis complex. bacterial species such as proteus morgani, proteus mirabilis, clostridium sp., pseudomonas paracolon, pathogenic escherichia coli and cocci have been isolated in association with a pneumoenteric syndrome of 35 newborn baboons, including neonates. the majority of these animals died with pulmonary factors such as anoxia and pneumonia. | 1975 | 808667 |
| susceptibility of current clinical isolates of pseudomonas aeruginosa and enteric gram-negative bacilli to amikacin and other aminoglycoside antibiotics. | the susceptibility of current clinical isolates of pseudomonas aeruginosa and enterobacteriaceae to amikacin and other aminoglycosides was tested by a standardized disk sensitivity method. minimal inhibitory concentrations (mics) were determined for all 200 isolates tested, and mean mics were calculated for each of 10 bacterial species. amikacin proved to be the most effective of six aminoglycosides against nine bacterial species; isolates of proteus morganii were slightly more sensitive to gent ... | 1976 | 825591 |
| the effect of exposure to impulse x rays on normal and epileptic activity in rabbit brain. | exposure to x rays (20 impulses of 4 hz frequency, total dose 0.6-1.1 mgy) increased the epileptic activity of a focal area, which was produced in the visual cortex of rabbit brain by freezing with liquid nitrogen, and by stimulating with flashes of light at frequencies of 5-6 hz. the number of seizure complexes during photostimulation for 5 s increased by 80% compared with the initial level, and this effect continued for 15 min. in control animals (with no epileptic foci), a decrease was observ ... | 1991 | 1797142 |
| the effect of exposure to impulse x rays on normal and epileptic activity in rabbit brain. | exposure to x rays (20 impulses of 4 hz frequency, total dose 0.6-1.1 mgy) increased the epileptic activity of a focal area, which was produced in the visual cortex of rabbit brain by freezing with liquid nitrogen, and by stimulating with flashes of light at frequencies of 5-6 hz. the number of seizure complexes during photostimulation for 5 s increased by 80% compared with the initial level, and this effect continued for 15 min. in control animals (with no epileptic foci), a decrease was observ ... | 1991 | 1797142 |
| in vitro activity evaluations of cefdinir (fk482, ci-983, and pd134393). a novel orally administered cephalosporin. | cefdinir, a so-called third-generation oral cephalosporin was tested in vitro against over 700 pathogens from patients with bacteremia. cefdinir was very active against the enterobacteriaceae with a 50% minimum inhibitory concentration (mic50) value range of less than or equal to 0.03-8 micrograms/ml. the enteric species having the highest mic90s (greater than or equal to 16 micrograms/ml) were citrobacter freundii, and the enterobacters, morganella morganii, proteus vulgaris, and serratia marce ... | 1991 | 1797457 |
| [therapeutic experience of proteus morganii septicemia with amikacin (author's transl)]. | | 1977 | 909148 |
| correlation of the characters fermentation of trehalose, non-transmissible resistance to tetracycline, and relatively long flagellar wavelength in proteus morganii. | an investigation of strains of proteus morganii isolated from patients in odense, denmark, and of 21 serotype strains revealed a close correlation between the fermentation of trehalose and a non-transmissible resistance to tetracycline. the trehalose fermenting, tetracycline resistant strains had a longer flagellar wavelength than the non-fermenting, sensitive strains. resistance to chloramphenicol occurred only in strains of the former group. | 1976 | 998259 |
| [susceptibilities of clinical bacterial isolates to antimicrobial agents, 1989. a study mainly focused on imipenem. the research group for testing imipenem susceptibilities of clinical isolates]. | we investigated susceptibilities of clinical bacterial isolates to imipenem (ipm) and other antimicrobial agents at hospital laboratories throughout japan from september to december of 1989. the susceptibility testing was carried out according to the 1-dilution or 3-dilution disc technique in which susceptibilities are classified into 4 grades: (+++), (++), (+) and (-). ipm showed markedly high in vitro activities against streptococcus pneumoniae, neisseria gonorrhoeae, moraxella catarrhalis, es ... | 1991 | 1798067 |
| [inducible cephalosporinases from proteus morganii]. | it has been shown that two proteus morganii strains produce an inducible cephalosporinase. no significative difference was shown between them: they present the same isoelectric poit: 8,3 and very similar kinetic constants. the parameter tau, proportional to the half life of antibiotic at low concentration, in presence of beta lactamase, shows that cefamandole is the most stable cephalosporin studied. | 1976 | 999950 |
| cefpodoxime: comparative antibacterial activity, influence of growth conditions, and bactericidal activity. | the antimicrobial activity of cefpodoxime, the active metabolite of the new cephalosporin ester cefpodoxime proxetil, in comparison to cefixime, cefotiam, cefuroxime, and cefotaxime was determined against a broad spectrum of freshly isolated gram-positive and gram-negative bacterial strains. cefpodoxime was demonstrated to be inhibitory at concentrations of less than or equal to 1 mg/l against 90% of strains of moraxella catarrhalis, haemophilus influenzae, escherichia coli (beta-lactamase- nega ... | 1991 | 1800379 |
| removal of the reca c-terminus results in a conformational change in the reca-dna filament. | the escherichia coli reca protein catalyzes homologous recombination of dna molecules, and the active form of the protein is a helical polymer that it forms around dna. previous image analysis of electron micrographs has revealed the reca protein to be organized into two domains or lobes within the reca-dna filament. we have now been able to show that a small modification of the reca protein by proteolysis results in a significant shift in the internal mass in the reca filament. we have cleaved ... | 1991 | 1804279 |
| proteus morganii meningitis treated with trimethoprim-sulfamethoxazole (co-trimoxazole). | | 1975 | 1040551 |
| modified macconkey medium which allows simple and reliable identification of providencia stuartii. | this work describes a modified macconkey medium (mcp medium) enabling the simple identification of providencia stuartii, an emerging nosocomial pathogen. a total of 813 strains, belonging to the families enterobacteriaceae and pseudomonadaceae, were tested on mcp medium; all p. stuartii strains were phosphatase positive, as were 97.5% of morganella morganii strains, in contrast with all other tested organisms. a simple discriminating test, such as the ornithine or citrate test, allowed identific ... | 1992 | 1323575 |
| horizontal transfer of a phosphatase gene as evidence for mosaic structure of the salmonella genome. | the genomes of escherichia coli and salmonella typhimurium are similar with respect to base composition, chromosome size, and the order, orientation and spacing of genes, but differ with respect to some 29 'loops', regions unique to one species. to evaluate the genetic basis for the structure and organization of the enteric bacterial genomes, we examined the gene encoding a non-specific acid phosphatase (phon) which maps to a loop at 96 min on the s.typhimurium chromosome. we detected atypical b ... | 1992 | 1339343 |
| in vitro folding pathway of phage p22 tailspike protein. | the intracellular chain folding and association pathway of the thermostable, trimeric phage p22 tailspike endorhamnosidase has been the subject of a previous detailed study employing temperature-sensitive folding mutants. recently, reconstitution of native tailspikes from completely unfolded polypeptides has been accomplished, providing a model system to compare protein folding pathways in vivo and in vitro. the in vitro reconstitution pathway of the protein after dilution from guanidine hydroch ... | 1991 | 1828991 |
| in vitro folding pathway of phage p22 tailspike protein. | the intracellular chain folding and association pathway of the thermostable, trimeric phage p22 tailspike endorhamnosidase has been the subject of a previous detailed study employing temperature-sensitive folding mutants. recently, reconstitution of native tailspikes from completely unfolded polypeptides has been accomplished, providing a model system to compare protein folding pathways in vivo and in vitro. the in vitro reconstitution pathway of the protein after dilution from guanidine hydroch ... | 1991 | 1828991 |
| production and purification of l-phenylalanine oxidase from morganella morganii. | an enzyme fraction, acting predominantly on l-phenylalanine has been purified and characterized from morganella morganii. the total envelope was prepared by disrupting the cells with a french press followed by high speed centrifugation. after solubilization of the particulate fraction with 0.1% triton x-100 and then centrifugation, the resulting supernatant was layered onto a deae-cellulose column. active fractions eluted were applied to a phenyl-sepharose cl-4b column as the final purification ... | 1991 | 1368081 |
| in vitro evaluation of gr69153, a novel catechol-substituted cephalosporin. | gr69153 is a c-7 catechol cephalosporin with a broad spectrum of activity against members of the family enterobacteriaceae (mics for 50% of strains tested [mic50s], 0.008 to 0.5 micrograms/ml), staphylococcus aureus (mic50, 4 micrograms/ml), pseudomonas aeruginosa (mic50, 0.25 micrograms/ml), haemophilus influenzae (mic50, 0.03 micrograms/ml), neisseria gonorrhoeae (mic50, 0.03 micrograms/ml), and acinetobacter spp. (mic50, 2 micrograms/ml). potent gr69153 activity was also demonstrated against ... | 1991 | 1854174 |
| recognition of morganella subspecies, with proposal of morganella morganii subsp. morganii subsp. nov. and morganella morganii subsp. sibonii subsp. nov. | the genus name morganella was established within the family enterobacteriaceae in 1978. morganella morganii is the only species described thus far within this genus, and the name m. morganii has been accepted by usage in the scientific community for strains previously known as proteus morganii. m. morganii isolates differ in their abilities to ferment trehalose and exhibit variable lysine and ornithine decarboxylase patterns, emphasizing the phenotypic heterogeneity within this species. previous ... | 1992 | 1390112 |
| mitochondrial damage by active oxygen species in vitro. | under in vitro conditions involving formation of active oxygen species, rat liver mitochondria were found to undergo swelling, peroxidative decomposition of lipids, and distinct disorganization of ultrastructure. supplementation with free radical scavengers such as superoxide dismutase (sod), methionine, histidine, and tryptophan accorded considerable protection to the organelle. a possible correlation between oxygen radicals, membrane integrity, and calcium functions is indicated. | 1991 | 1855671 |
| cefdinir (fk482), an orally administered cephalosporin in vitro activity comparison against recent clinical isolates from five medical centers and determination of mic quality control guidelines. | cefdinir, a new oral cephalosporin, was compared to cefaclor, cefadroxil, cefixime, and cefuroxime against greater than 5000 recent aerobic clinical isolates. this multicenter study revealed broad-spectrum cefdinir activity against all enterobacteriaceae (mic50s, 0.06-2 micrograms/ml) except enterobacter cloacae, morganella morganii, proteus vulgaris, and serratia marcescens (mic50s, greater than or equal to 4 micrograms/ml). oxacillin-susceptible staphylococci (mic90s, 0.5-2 micrograms/ml), bet ... | 1992 | 1424507 |
| [synergistic action of cefodizime with other antimicrobial agents on clinically isolated microorganisms. ii. synergistic action with sisomicin]. | cefodizime (cdzm) possesses a broad antimicrobial spectrum and a relatively long half life in the blood. in addition, it shows excellent therapeutic efficacies in the treatment of infections in leukopenic animal models, hence it is expected that cdzm may have good efficacies against various infections in immunocompromised hosts. in the meantime, sisomicin (siso) not only has strong antibacterial activities against gram-negative rods (gnr), but has relatively low nephrotoxicity and ototoxicity. t ... | 1992 | 1495193 |
| experience with calcium antagonists nitrendipine, diltiazem, and verapamil and beta 2-agonist salbutamol in salvaging ischemic skin flaps in rabbits. | this study investigated the efficacy of selected agents in the salvage of experimental skin flaps in rabbits after 21 hours of 25 degrees c ischemia. calcium channel antagonists nitrendipine, diltiazem, and verapamil increased ischemic skin flap survival in rabbits from 33.3% for buffered saline infused controls to 71.4% (p less than 0.05), 71.4% (p less than 0.05), and 50.0% (not significant) respectively. the beta 2-adrenoceptor agonist salbutamol produced an increase in survival to 64.3%, whi ... | 1991 | 1865808 |
| in vitro and in vivo evaluation of ro 09-1428, a new parenteral cephalosporin with high antipseudomonal activity. | ro 09-1428, a new parenteral cephalosporin with a catechol moiety attached at position 7 of the cephalosporin ring, showed high in vitro activity against escherichia coli, klebsiella pneumoniae, proteus mirabilis, proteus vulgaris, and streptococcus pyogenes, with mics for 90% of strains tested (mic90s) of less than or equal to 0.39 micrograms/ml. morganella morganii, providencia rettgeri, citrobacter freundii, haemophilus influenzae, staphylococcus aureus, and streptococcus pneumoniae were inhi ... | 1991 | 1906261 |
| the acute response of the umbilical artery pulsatility index to changes in blood volume in fetal sheep. | this experimental study was designed to test the effects of acute changes in fetal circulating blood volume on the umbilical artery pulsatility index (pi). six fetal sheep were provided with an electromagnetic flow meter for measurement of umbilical venous blood flow, with catheters for determination of arterial blood pressure and umbilical venous pressure, and with a 5 mhz doppler transducer around one umbilical artery for flow velocity waveform analysis. a catheter in the inferior vena cava wa ... | 1992 | 1563562 |
| [functional inactivation of centrosome of mouse 3t3 cells by heat shock]. | the microtubule assembly capacity of centrosome has been tested in mouse 3t3 cells. following heat shock (30 min. at 43.5 degrees c), centrosomes display a total lack of microtubule nucleation. this stress leads to functional arrest of the organelle. the natural control of the activity of the centrosome is therefore questionable. | 1991 | 1913241 |
| a rare case of chorioamnionitis by morganella morganii complicated by septicemia and adult respiratory distress syndrome. | morganella morganii, a gram-negative bacterium, usually infects older patients with urinary catheters, but does not commonly affect pregnant women. in this report we present a case of chorioamnionitis caused by morganella morganii. the case was complicated by a life-threatening adult respiratory distress syndrome. | 1992 | 1618364 |
| regulated degradation of ornithine decarboxylase requires interaction with the polyamine-inducible protein antizyme. | intracellular degradation of vertebrate ornithine decarboxylase (odc) is accelerated by polyamines, the products of the pathway controlled by odc. antizyme, a reversible, tightly binding protein inhibitor of odc activity, is believed to be involved in this process. mouse and trypanosoma brucei odcs are structurally similar, but the trypanosome enzyme, unlike that of the mouse, is not regulated by intracellular polyamines when expressed in hamster cells (l. ghoda, d. sidney, m. macrae, and p. cof ... | 1992 | 1630460 |
| [antibiotic sensitivity of bacteria isolated from patients at 6 hospitals in osaka]. | we examined mics of 6 oral new quinolones and 4 oral cephems against bacteria isolated from patients at 6 hospitals in osaka during the period from january to june in 1990, and the following results were obtained. 1. all species excluding streptococcus pyogenes were more sensitive with less frequencies of resistance to new quinolones than to cephems. in new quinolones, tosufloxacin (tflx) was the most active against gram-positive cocci and ciprofloxacin (cpfx) and tflx had the highest activities ... | 1991 | 1960855 |
| [antibacterial activities of ofloxacin against recent isolates from patients with community-acquired infections]. | in order to survey antibacterial activities of ofloxacin (oflx) against 1,440 bacterial strains isolated from patients with community-acquired infections in 1987 and 1990, minimum inhibitory concentrations (mics) of the drug as well as those of other new quinolones and oral cephems were determined. the following conclusions were reached. 1. comparison of the mic distribution for strains isolated in 1987 with those in 1990 suggested a tendency toward an increase in the frequency of oflx-resistant ... | 1991 | 1960856 |
| study of the oxidative metabolic function and chemotaxis of neutrophils from patients with cancer influenced by selenium yeast. | the effects of selenium yeast (sy) given orally to patients with cancer on the oxidative metabolic function and chemotaxis of neutrophils were studied by lumino-dependent chemiluminescence (cl) assay and agarose plates assay, respectively. the results showed that the background cl and the peak value cl of neutrophils from patients with cancer 14 d after taking sy were, on the average, 4 and 1.2 times higher than those before taking sy. the chemotactic index (ci) and chemotactic differential (cd) ... | 1990 | 1698418 |
| protein profile typing--a new method of typing morganella morganii strains. | a new, simple and stable method for typing morganella morganii strains is described. the 150 strains examined, principally from faeces, contained haemolytic and non-haemolytic representatives of diverse o serogroup, bacteriocin type and biotype. among the biotypes were some trehalose-fermenting, tetracycline-resistant strains and some non-motile, tetracycline-sensitive, glycerol fermenters. after analysis of cell lysates by sodium dodecyl sulphate-discontinuous polyacrylamide gel electrophoresis ... | 1990 | 1701835 |
| preferential hydrolysis of cis configuration compounds at the 3,4 position of monobactams by beta-lactamase from morganella morganii. | carumonam and bo-1166 (cis configuration) were inactivated by beta-lactamase of morganella morganii more rapidly than were aztreonam and bo-1165 (trans configuration), as demonstrated by spectrophotometric analysis and microbiological assay. an active enzyme was recovered more rapidly from the inactivated enzyme-monobactam complex derived from the cis form of monobactams than from the complex derived from the trans form of monobactams. this result suggests that the configuration at the 3,4 posit ... | 1991 | 2039196 |
| [antibacterial activity of ciprofloxacin against fresh clinical isolates from superficial suppurative foci]. | the minimum inhibitory concentrations (mics) of 5 drugs (ciprofloxacin (cpfx), and 4 drugs used as standard) were determined to investigate antibacterial potencies of cpfx against bacterial strains isolated in 1989 from superficial suppurative foci. the clinical isolates tested included 375 strains from 11 aerobic bacterial species, and 50 strains from 2 anerobic bacterial genera (group) for a total of 425 isolates. interpreting mic level distributions of these drugs as the expression of antibac ... | 1991 | 2041153 |
| [antimicrobial susceptibilities of clinical isolates of morganella-proteus-providencia group of bacteria]. | we examined in vitro susceptibilities of 3,109 isolates belonging to 5 species of proteeae to 2 penicillins, 5 cephems and 2 aminoglycosides. the isolates were collected from 69 hospital laboratories throughout japan between 1986 and 1988. minimal inhibitory concentrations were determined using the agar dilution method with inoculation of 10(8) cells/ml of bacteria. proteus mirabilis had marked susceptibilities to the penicillins and cephems tested. proteus vulgaris and morganella morganii were ... | 1991 | 2041155 |
| dna single strand-breaks in lymphocytes after metronidazole therapy. | dna single strand-breaks were examined in lymphocytes of patients treated with metronidazole (cas 443-48-1) for trichomonas vaginalis infection before, on day one, and day seven of treatment. recommended dosage of metronidazole induces dna single strand-breaks. single strand-breaks were repaired after therapy. no irreversible dna damage remains. the dna repair mechanisms are genetically determined. therefore a mutagenic effect of metronidazole must be discussed in patients with dna repair defect ... | 1991 | 2043178 |
| re: "probability of introducing diseases because of false negative test results". | | 1991 | 2043200 |
| properties of a rat monoclonal antibody reactive with both the mannan of candida species and the o-antigen 6,7 polysaccharide of serogroup c1 salmonellae. | monoclonal antibody masc1-mr9 of isotype immunoglobulin m was generated in lou/c rats by immunization with heat-killed salmonella thompson (serogroup c1, o-antigen 6,7 lipopolysaccharide) bacteria which had been further enriched for o-antigen by coating with homologous lipopolysaccharide. eight monoclonal antibodies were selected by screening against the lipopolysaccharide of s. thompson. in a subsequent test against candida mannan, only one antibody, masc1-mr9, was reactive. immunofluorescence ... | 1991 | 1702760 |
| new o antigens of morganella morganii and the relationships between haemolysin production. o antigens and morganocin types of strains. | a collection of 142 strains of morganella morganii, principally from unrelated patients' faeces was examined to determine the relationship, if any, between haemolysin production, o antigen and morganocin production/sensitivity type. only 55 (38.7%) were agglutinable with the existing 44 o antisera. however, when o antisera were raised to some of the non-typable strains 11 new o antigens were found and 126 (88.7%) of the strains were typable. the number of o antigenic groups in m. morganii is now ... | 1990 | 1711754 |
| fumonisin mycotoxins and equine leukoencephalomalacia. | | 1991 | 2045319 |
| the efficacy of polysporin first aid antibiotic spray (polymyxin b sulfate and bacitracin zinc) against clinical burn wound isolates. | polysporin first aid antibiotic spray (burroughs wellcome co., research triangle park, n.c.) is a dry spray containing 200,000 units aerosporin (polymyxin b sulfate) and 10,000 units bacitracin zinc, along with a propellant. each 1-second spray delivers approximately 2300 units of polymyxin b sulfate and 115 units of bacitracin zinc. this study was designed to evaluate the efficacy of polysporin spray against various clinical isolates. blood agar plates were inoculated with a pure culture of eac ... | 1991 | 2050717 |
| a comparison of the mechanisms of decreased susceptibility of aztreonam-resistant and ceftazidime-resistant enterobacteriaceae. | twenty five strains of enterobacteriaceae (five each of enterobacter cloacae, citrobacter freundii, serratia marcescens, morganella morganii and providencia stuartii) were exposed to aztreonam and ceftazidime at 1/2 and 1 x mic in liquid medium for 22 h, and also to 3, 5 and 10 x mic and 16 mg/l of each agent in agar. any putative mutant with an increase in the mic of greater than or equal to 4 fold was examined for beta-lactamase expression and outer membrane protein profile. mutants were selec ... | 1990 | 2081717 |
| [aids pathology: various critical considerations (especially regarding the brain, the heart, the lungs, the hypophysis and the adrenal glands]. | our studies on pathology of aids point to four major conclusions. 1) the brain is often directly affected by the hiv infection (with the characteristics of subacute microglial encephalitis with pathognomonic multinucleated giant cells) and then by opportunistic infections such as cytomegalovirus, herpes-virus, papova-virus jc (with progressive multifocal leucoencephalopathy), mycobacterium tuberculosis, toxoplasma gondii, cryptococcus neoformans, candida albicans and aspergillus fumigatus; oppor ... | 1990 | 2094837 |
| hydrogen ion currents in rat alveolar epithelial cells. | alveolar epithelial cells isolated from rats and maintained in primary culture were studied using the whole-cell configuration of the "patch-clamp" technique. after other ionic conductances were eliminated by replacing permeant ions with n-methyl-d-glucamine methanesulfonate, large voltage-activated hydrogen-selective currents were observed. like h+ currents in snail neurons and axolotl oocytes, those in alveolar epithelium are activated by depolarization, deactivate upon repolarization, and are ... | 1991 | 1722118 |
| ancylostoma ceylanicum: immunological consequences after anthelmintics therapy in hamsters (mesocricetus auratus). | alterations in immunological response before and after chemotherapy were investigated in hamsters infected with a. ceylanicum. four reference anthelmintics mebendazole, albendazole, levamisole and pyrantel pamoate and one newly synthesized anthelmintic compound 81-470 were used. drugs in curative doses were administered on day 30 post infection and the humoral response was assessed by counter immunoelectrophoresis and elisa and cell mediated immunity by delayed type of hypersensitivity reaction. ... | 1991 | 1769725 |
| [antimicrobial activities of gentamicin against fresh clinical isolates]. | antimicrobial activities of gentamicin (gm), compared with activities of other aminoglycosides (ags) and beta-lactam antibiotics, were studied against clinical isolates obtained during a period of july-december 1989. 1. gm-resistant strains were noted in 24% of staphylococcus aureus, 12% of enterobacter spp., 24% of serratia marcescens, 7% of morganella morganii and 26% of pseudomonas aeruginosa, but no gm-resistant strains were observed among isolates of escherichia coli, klebsiella pneumoniae, ... | 1990 | 2128340 |
| [a rare cause of non-nosocomial pneumonia in a healthy adult: morganella morganii]. | | 1990 | 2147508 |
| beta-lactamase expression and outer membrane protein changes in cefpirome-resistant and ceftazidime-resistant gram-negative bacteria. | twenty-five strains of enterobacteriaceae (five each of enterobacter cloacae, citrobacter freundii, serratia marcescens, morganella morganii, and providencia stuartii) and five strains of pseudomonas aeruginosa were exposed to various concentrations of cefpirome or ceftazidime in agar. mutants with a greater than four-fold increase in the mic were examined for changes in beta-lactamase expression and outer membrane protein (omp) profile. both agents selected mutants with decreased susceptibility ... | 1991 | 1778852 |
| selection and characterization of cefepime-resistant gram-negative bacteria. | the nctc type strains and four clinical isolates of enterobacter cloacae, citrobacter freundii, serratia marcescens, morganella morganii, providencia stuartii and pseudomonas aeruginosa were exposed, in agar, to cefepime at 3, 5, and 10 x mic and a breakpoint concentration of 16 mg/l. mutants were selected at a frequency of approximately 10(-8) that had decreased susceptibility to cefepime and cefpirome, and species-dependent resistance to other beta-lactams. any putative mutant with a greater t ... | 1991 | 1778870 |
| effect of fasting on uteroplacental amino acid metabolism in the pregnant sheep. | in the fed state, the net utilization of most amino acids by the ovine uteroplacental unit (defined as uterine uptake minus umbilical uptake) is zero. this study was to determine if this is true for the fasted pregnant ewe also, when uteroplacental glucose uptake is diminished. glucose and amino acid concentrations were determined in 9 pregnant ewes across the uterine and umbilical circulations. uterine and umbilical blood flows were determined by the steady state antipyrine diffusion method, an ... | 1991 | 1797124 |
| effect of fasting on uteroplacental amino acid metabolism in the pregnant sheep. | in the fed state, the net utilization of most amino acids by the ovine uteroplacental unit (defined as uterine uptake minus umbilical uptake) is zero. this study was to determine if this is true for the fasted pregnant ewe also, when uteroplacental glucose uptake is diminished. glucose and amino acid concentrations were determined in 9 pregnant ewes across the uterine and umbilical circulations. uterine and umbilical blood flows were determined by the steady state antipyrine diffusion method, an ... | 1991 | 1797124 |
| kinetics of the reaction of prostaglandin h synthase compound ii with ascorbic acid. | the reduction of prostaglandin h synthase compound ii by ascorbic acid in the presence of diethyldithiocarbamate was studied in 0.1 m phosphate buffer (ph 8.0) at 4.0 +/- 0.5 degrees c, by rapid scan spectrometry and transient state kinetics. a saturation effect and nonzero intercept were observed in the plot of pseudo-first-order rate constant versus ascorbic acid concentration. the saturation behavior suggests formation of a complex between prostaglandin h synthase compound ii and ascorbic aci ... | 1990 | 2168160 |
| electroencephalographic response of canine hippocampus to intraventricular gaba. | the effect of intraventricularly administered gaba on hippocampus was investigated by recording its electrical activity after chronic implantation of cannulae and bipolar electrode in five male beagle dogs. gaba was introduced in 40 mg/kg b. weight so as to exceed its physiological levels in csf. recordings were made within two hours after microinjection in third ventricle. the predominant pattern of eeg depicted synchronization. the progressing synchronization of eeg suggests induction of funct ... | 1991 | 1797660 |
| in vitro activity of temafloxacin hydrochloride (ta-167 or a-62254), a new fluorinated 4-quinolone. | the in vitro antibacterial activity of temafloxacin hydrochloride (ta-167 or a-62254) was evaluated against a wide variety of clinical isolates and compared with those of other fluoroquinolones. the potency (mic90) of the compound against gram-positive aerobic bacteria was higher or comparable to those of ciprofloxacin, ofloxacin, and norfloxacin. against most gram-negative enteric bacteria and pseudomonas species, temafloxacin was less active than ciprofloxacin, but was generally as active as o ... | 1990 | 2209168 |
| infection with bacterial enteropathogens in swedish travellers to south-east asia--a prospective study. | infection with potential bacterial enteropathogens was studied prospectively in 94 swedish travellers. three faecal samples were collected, regardless of diarrhoeal symptoms, after each of three 1-week stays in singapore, hong kong and japan. the specimens were analyzed for salmonella, shigella, yersinia, campylobacter and different enterotoxin-producing bacteria. a potential enteropathogen was identified in 30% (28/94) of the participants, i.e. in 26% of the healthy and in 39% of the travellers ... | 1990 | 2209737 |
| electroencephalographic response of canine hippocampus to intraventricular gaba. | the effect of intraventricularly administered gaba on hippocampus was investigated by recording its electrical activity after chronic implantation of cannulae and bipolar electrode in five male beagle dogs. gaba was introduced in 40 mg/kg b. weight so as to exceed its physiological levels in csf. recordings were made within two hours after microinjection in third ventricle. the predominant pattern of eeg depicted synchronization. the progressing synchronization of eeg suggests induction of funct ... | 1991 | 1797660 |
| antibacterial activity of cefpodoxime in comparison with cefixime, cefdinir, cefetamet, ceftibuten, loracarbef, cefprozil, bay 3522, cefuroxime, cefaclor and cefadroxil. | the new oral cephalosporins cefpodoxime, cefixime, cefdinir, cefetamet and ceftibuten demonstrate enhanced activity against enterobacteriaceae susceptible to the established compounds as well (e.g. cefuroxime, cefaclor, cefadroxil). in addition, cefpodoxime, cefixime, cefdinir, cefetamet and ceftibuten include in their spectrum species hitherto resistant to oral cephalosporins (proteus vulgaris, providencia spp., yersinia enterocolitica). besides, the majority of these compounds demonstrate rele ... | 1991 | 1800377 |
| [the effect of zinc on mineral, hematological and immunological indices in calves]. | the aim of this work was to study the effect of zinc added to feed on some selected biochemical and haematological indices and its stimulatory action on immunity of calves during its physiological decrease. investigations were carried out on 18 calves aged 20 days. twelve calves were divided into 2 groups and they received 450 and 900 mg of zn++ under the form of znso4 x 7h2o. the following parameters were examined: serum and tissue concentrations of zn, cu, fe and ca, number of erythrocytes and ... | 1991 | 1821031 |
| use of peyer's patch and lymph node fragment cultures to compare local immune responses to morganella morganii. | lymphoid tissue fragment cultures were established to analyze the differentiative processes among b cells in peyer's patches (pp) and peripheral lymph nodes (pln), especially those in germinal centers. pp cultures from both conventionally reared mice and formerly germ-free mice colonized with morganella morganii could be maintained for greater than 12 days with continued b-cell division, especially among cells binding high levels of peanut agglutinin, a characteristic of germinal center cells. p ... | 1991 | 1825484 |
| astrocytes: a possible primary site for colchicine-mediated neurotoxicity in the rat striatum. | ultrastructural changes in rat astrocytes including endfoot swelling and rupture of plasma membranes were seen as early as 1 h after injection of 6.0 micrograms colchicine (co) into the striatum. significant change in neuronal morphology was not seen by 24 h. astrocytes may therefore be primary targets for co-mediated damage, which then may have secondary neurotoxic consequences. | 1991 | 1828783 |