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[hplc study of the inhibition of enterobacterial cephalosporinases by cefmenoxime].high performance liquid chromatography (hplc) has shown that cefmenoxime and cefotaxime are stable to the cephalosporinase of enterobacter cloacae p99 , morganella morganii gn 1510 and serratia liquefaciens 132. they are significantly resistant to hydrolysis by 100 cephalosporinase units (cephalosporinase production of 10(12) bacterial). cefmenoxime and cefotaxime are also inhibitors of cephalosporinase at the concentration of 5.10-10 micrograms per 10-10 unit of enzyme.19846330649
aztreonam in the treatment of serious orthopedic infections.aztreozam was evaluated in the treatment of a variety of orthopedic infections. included were 17 patients with osteomyelitis, three with purulent arthropathy with prostheses, and 16 with superficial infections secondary to trauma or surgical procedure. pathogens were gram-negative bacilli sensitive to aztreonam. concomitant antibiotics were administered for gram-positive cocci that were present initially or by superinfection. infecting organisms included pseudomonas aeruginosa (minimal inhibitor ...19853881949
serious nosocomial infection caused by morganella morganii and proteus mirabilis in a cardiac surgery unit.in july and august 1981, five patients in the cardiac surgery unit of the bristol royal infirmary developed septicemia caused by morganella morganii, proteus mirabilis, or both of these species. three of the patients had serious wound infections, and three of the patients died. typing of the m. morganii isolates by o-serotyping and of the p. mirabilis isolates by o-serotyping, proticine production and sensitivity, and the dienes reaction confirmed cross infection by both species. although m. mor ...19836350354
third-generation cephalosporins: a critical evaluation.six third-generation cephalosporins--cefotaxime, moxalactam, cefoperazone, ceftizoxime, ceftriaxone, and cefmenoxime--are reviewed; covered are chemistry and structure-activity relationships, mechanism of action, spectra of activity, pharmacokinetics, clinical utility, adverse effects, and cost effectiveness. the third-generation cephalosporins have a similar mechanism of action to that of other beta-lactam antibiotics. none of the agents is particularly active against certain gram-positive bact ...19846432420
comparative evaluation of the eiken and api 20e systems and conventional methods for identification of members of the family enterobacteriaceae.to evaluate the accuracy and utility of the eiken systek no. 1 (eiken system; eiken chemical co., ltd., tokyo, japan), we conducted a clinical comparison, with 345 enterobacteriaceae isolates, of the eiken system with api 20e (analytab products, inc., plainview, n.y.) and conventional methods. the eiken system is a 21-biochemical-test battery tray stored at 25 degrees c and inoculated in one step. it is similar to the api 20e except that the eiken system contains malonate, adonitol, and maltose; ...19846490860
morganella morganii: epidemiology of bacteremic disease.a retrospective review of microbiology records revealed 19 documented episodes of m. morganii bacteremia in 18 patients at a veterans administration hospital during a 5.5 year period. thirteen of 19 bacteremias were related to nosocomial infections; 11 of the 13 nosocomial bacteremias occurred in surgical patients. nine of the 13 patients with nosocomial bacteremia had received recent therapy with a beta-lactam antibiotic. the most common source of bacteremia was a postoperative wound infection ...19846561180
the in vitro antimicrobial activity of desacetylcefotaxime compared to other related beta-lactams.like all other cephalosporins that contain an acetyl side chain in the 3' position, cefotaxime (ctx) is partially desacetylated in vivo. desacetylcefotaxime (des-ctx) possesses a broad antimicrobial spectrum and high beta-lactamase stability. with the exception of pseudomonas aeruginosa, morganella morganii, bacteroides fragilis, and staphylococcus aureus, most strains of other species tested usually had mean mics of des-ctx lower than 1 microgram/ml. its activity is generally lower than that of ...19846086214
efficacy of ceftizoxime administered twice daily in hospitalized patients with respiratory tract infections.the efficacy and safety of ceftizoxime administered twice daily were evaluated in 215 hospitalized patients with documented lower respiratory tract infections. the majority of patients received 1 to 2 gm of ceftizoxime intramuscularly or intravenously every 12 hours; the mean dosage was 2 gm/day, and the mean duration of therapy was 8.9 days. clinical cure was achieved in 204 (95%) of the 215 patients with lower respiratory tract infection. one hundred and thirty-eight patients were both clinica ...19846097357
in vitro activity and beta-lactamase stability of cefmenoxime.the activity of cefmenoxime, an aminothiazolyl cephalosporin, was studied against 650 bacteria. it was slightly less active than cefotaxime and more active than moxalactam against staphylococci. it had activity similar to that of cefotaxime and ceftizoxime against group a and b streptococci and streptococcus pneumoniae. it did not inhibit streptococcus faecalis or listeria spp. cefmenoxime had activity similar to that of cefotaxime, ceftizoxime, ceftazidime, and moxalactam against escherichia co ...19826100427
evaluation of a two-hour method for screening pathogens from stool specimens.the 2-h stool-screening test (sst) (api system s.a., montalieu-vercieu, france) was used to screen 231 organisms yielding suspicious colonies on stool differential agars for potential pathogens. all 54 salmonellae yielded correct screens. of 14 shigellas, 9 keyed as possible shigella spp.-yersinia enterocolitica-rare salmonella spp. (sys), and 5 (all shigella sonnei) keyed as possible s. sonnei-y. enterocolitica-arizona spp. (sya). three arizona strains were identified as probable salmonella spp ...19846386849
haemagglutinins and fimbriae of morganella, proteus and providencia.one hundred and thirteen strains of morganella, proteus and providencia, grown in different cultural conditions, were examined for their ability to produce haemagglutinins (has). three main kinds of ha (ms, mr/k and mr/p) were detected, and 89% of the 112 ha+ strains were capable of producing two or three of the different has in the same or different cultures. the properties of the three has were partly defined and the difficulties of identifying their separate ha activities when present togethe ...19826129324
in vitro antibacterial activity and beta-lactamase stability of sy5555, a new oral penem antibiotic.the antibacterial activity of sy5555, a new oral penem antibiotic, was compared with those of cefaclor, cefixime, and cefteram. sy5555 was more active than the comparison agents against methicillin-susceptible staphylococcus aureus, staphylococcus epidermidis, streptococcus pneumoniae, enterococcus faecalis, citrobacter freundii, enterobacter cloacae, morganella morganii, acinetobacter calcoaceticus, clostridium spp., and bacteroides fragilis. against providencia spp., proteus spp., and haemophi ...19947811005
isolation of three hexahydro-1,3,5-trinitro-1,3,5-triazine-degrading species of the family enterobacteriaceae from nitramine explosive-contaminated soil.three species of the family enterobacteriaceae that biochemically reduced hexahydro-1,3,5-trinitro-1,3,5-triazine (rdx) and octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (hmx) were isolated from nitramine explosive-contaminated soil. two isolates, identified as morganella morganii and providencia rettgeri, completely transformed both rdx and the nitroso-rdx reduction intermediates. the third isolate, identified as citrobacter freundii, partially transformed rdx and generated high concentratio ...19947811097
in vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim.enoxacin is a new quinolone carboxylic acid compound. its activity against 740 bacterial isolates was determined. it inhibited 90% escherichia coli, klebsiella sp., aeromonas sp., enterobacter spp., serratia spp., proteus mirabilis, and morganella morganii at less than or equal to 0.8 micrograms/ml. the majority of pseudomonas aeruginosa was inhibited by less than or equal to 3.1 micrograms/ml. haemophilus spp. and neisseria spp. were inhibited by less than 0.1 micrograms/ml. although most staph ...19836229216
treatment of experimental chronic osteomyelitis caused by morganella morganii with mezlocillin and cloxacillin.mezlocillin was used alone and in combination with cloxacillin in the treatment of chronic experimental osteomyelitis due to morganella morganii. this combination showed in vitro synergy as measured by the checkerboard technique. a marked inoculum affect was demonstrated in vitro with mezlocillin and the infecting strain of m. morganii. in therapeutic trials, mezlocillin administered for 28 days was totally ineffective. the combination of mezlocillin and cloxacillin (at 800 and 400 mg/kg, respec ...19846563980
in vitro activity of cp-99,219, a novel 7-(3-azabicyclo[3.1.0]hexyl) naphthyridone antimicrobial.the in vitro activity of cp-99,219 was compared with that of ciprofloxacin and sparfloxacin against 814 clinical bacterial isolates using a microdilution method with brain-heart infusion broth. cp-99,219 was the most potent agent tested against methicillin-resistant, ciprofloxacin-susceptible staphylocci (minimum inhibitory concentration [mic]90 < or = 0.25 microgram/ml). cp-99,219 was 32-fold and fourfold more potent than ciprofloxacin and sparfloxacin, respectively, against streptococcus pneum ...19947851087
in vitro activity of pefloxacin compared to that of quinolones and other antimicrobial agents.pefloxacin is a new methyl-4-piperazinyl quinolone. it had mic90 values of less than 0.01 to 0.8 micrograms/ml for the majority of escherichia coli, klebsiella, oxytoca, citrobacter, providencia, enterobacter cloacae, enterobacter aerogenes, morganella and proteus mirabilis. it inhibited ampicillin, cephalexin and nalidixic acid resistant isolates of these species. against pseudomonas the pefloxacin mic90 was 3.1 micrograms/ml. staphylococcus aureus had a mic50 of 0.4 micrograms/ml and a mic90 o ...19846241847
in vitro antagonism between n-formimidoyl thienamycin and aztreonam, ticarcillin and ticarcillin/clavulanic acid.one-hundred eighty-seven bacterial strains were tested by the two-disk-agar diffusion method for the interaction between n-formimidoyl thienamycin and aztreonam, ticarcillin and ticarcillin-clavulanic acid. an antagonism between n-formimidoyl thienamycin and the other 3 beta-lactams was noted in half of the evaluable tests, especially against pseudomonas, escherichia coli and morganella.19846594965
comparison of micro-id and api 20e in rapid identification of enterobacteriaceae.the effectiveness of micro-id and api 20e as same-day identification systems for enterobacteriaceae was evaluated in comparison with conventional identification by using 315 clinical isolates and 90 stock strains. the api 20e system was heavily inoculated according to manufacturer's recommendations for same-day identification. we found that 83 and 81% of isolates provided adequate inocula for micro-id and api 20e, respectively, and purity of the heavy inocula was not a problem with either system ...19827047556
comparison of two methods for same-day identification of enterobacteriaceae.two commercial methods, api 20e (as modified for same-day enterobacterial identification) and micro-id, were evaluated for ability to provide useful same-day information of 368 clinically isolated enterobacteriaceae. organisms included escherichia coli (54), shigella (7), edwardsiella tarda (1), salmonella enteritidis (10), citrobacter (30), klebsiella (55), enterobacter (68), hafnia alvei (2), serratia (33), proteus (64), morganella morganii (24), providencia (18), and yersinia enterocolitica ( ...19827051807
synergistic activity of mecillinam in combination with the beta-lactamase inhibitors clavulanic acid and sulbactam.the beta-lactamase inhibitors clavulanic acid and sulbactam were combined with mecillinam. beta-lactamase-containing escherichia coli resistant to mecillinam was synergistically inhibited by both clavulanic acid and sulbactam. beta-lactamase-containing enterobacter was synergistically inhibited, but strains lacking beta-lactamases were not synergistically inhibited. synergistic inhibition was noted for beta-lactamase-containing, mecillinam-resistant klebsiella, citrobacter, serratia, and salmone ...19826291454
cloning and characterization of the napa acid phosphatase/phosphotransferase of morganella morganii: identification of a new family of bacterial acid-phosphatase-encoding genes.the gene encoding a minor phosphate-irrepressible acid phosphatase (named napa) of morganella morganii was cloned and sequenced, and its product characterized. napa is a secreted acid phosphatase composed of four 27 kda polypeptide subunits. the enzyme is active on several organic phosphate monoesters but not on diesters, and is also endowed with transphosphorylating activity from organic phosphoric acid esters to nucleosides and other compounds with free hydroxyl groups. its activity is inhibit ...19957894706
in vitro studies of bmy-28142, a new broad-spectrum cephalosporin.bmy-28142 was compared with other broad-spectrum antibiotics against gram-positive cocci and gram-negative bacilli. bmy-28142 was highly active against all gram-negative bacilli and especially against enterobacter cloacae, serratia marcescens, and morganella morganii. its in vitro activity suggests that bmy-28142 should prove to be useful for the treatment of gram-negative bacillary infections.19853838637
penem derivatives: beta-lactamase stability and affinity for penicillin-binding proteins in escherichia coli.penem derivatives, a new group of beta-lactam antibiotics with potent activities against a wide range of bacteria, including pseudomonas aeruginosa, were tested for their stability against hydrolysis by beta-lactamases purified from clinical isolates of morganella morganii. proteus vulgaris, and escherichia coli and by a penicillinase from bacillus cereus. penems having 6 alpha substituents, such as hydroxyethyl, hydroxymethyl, and ethyl groups, were very stable against hydrolysis by each of the ...19827049076
microbiological surveillance during selective decontamination of the digestive tract (sdd)the use of selective decontamination of the digestive tract (sdd) as prophylaxis against nosocomial respiratory tract infection remains controversial, largely because of concerns that, in the long term, it may promote the emergence of antibiotic-resistant strains. this report describes the results of surveillance cultures and susceptibility testing undertaken during the course of a 2-year, double-blind study of the efficacy of sdd which was conducted in a respiratory intensive care unit (icu). s ...19947868405
[antibacterial activities of isepamicin against fresh clinical isolates of gram-negative bacilli].to investigate antibacterial activities of isepamicin (isp), mics of isp as well as other aminoglycosides (ags) were determined against many strains of gram-negative bacilli that were clinically isolated in 1993. 1. no isp-resistant strains were observed among isolates of escherichia coli, citrobacter diversus, klebsiella spp., enterobacter spp. or proteus mirabilis. 2. isp-resistant strains were observed among isolates of citrobacter freundii, serratia spp., proteus vulgaris, morganella morgani ...19947933534
comparative in-vitro activity of quinolone carboxylic acids against proteeae.the in-vitro susceptibilities of 198 isolates of precisely identified proteeae species to six quinolone antimicrobials were determined. significant differences in susceptibility patterns among various proteeae to the quinolones examined were demonstrated. although providencia stuartii was found to be the most resistant to quinolones including the very active agent ciprofloxacin, fully speciated prov. rettgeri were also markedly resistant as well. in contrast prov. alcalifaciens was extremely sen ...19846511707
nonspecific induction of beta-lactamase in enterobacter cloacae.since the introduction of the new beta-lactamase-stable beta-lactam compounds, inducible beta-lactamases have become increasingly important clinically [1]. it has recently been pointed out that most beta-lactam antibiotics appear to be affected by these derepressed enzymes either by hydrolysis or by the nonhydrolytic barrier mechanism [2]. until now, it has generally been assumed that beta-lactamases are induced only by the beta-lactam compounds themselves. we investigated an e cloacae strain th ...19836605393
hand carriage of aerobic gram-negative rods by health care personnel.a quantitative culture technique (hand washed in a glove containing broth for 30 s) was used to determine the frequency of hand carriage of aerobic gram-negative rods by various groups of health care workers and 104 control subjects. overall, 31% of health care workers carried aerobic gram-negative rods on their hands compared to 59% of control subjects (p < 0.001). enterobacter agglomerans accounted for 40% of the isolates, and other enterobacter spp. 7%. other organisms included acinetobacter ...19827097001
commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut.we have employed a germfree mouse model to study the development and persistence of a humoral mucosal immune response to a gram-negative murine commensal organism, morganella morganii. m. morganii bacteria rapidly colonize the gut, resulting in hypertrophy of peyer's patches (pp), including germinal center reactions (gcr), and the development of specific immunoglobulin a (iga) responses detected in vitro in pp fragment cultures and by elispot assays of lamina propria cells. the gcr peaks 14 days ...19957558298
in vitro antimicrobial activity evaluation of cefodizime (hr221), a new semisynthetic cephalosporin.cefodizime (hr221) is a new alpha-methoxyimino cephalosporin developed by hoechst-roussel with a reported serum half-life of over 2 h. in vitro susceptibility studies showed that the cefodizime spectrum includes all those enterobacteriaceae, staphylococci, streptococcus spp., haemophilus spp., and neisseria spp. normally susceptible to cefotaxime (hr756) or ceftizoxime (fk749) or both. cefodizime was less active (two- to eightfold) than cefotaxime or ceftizoxime against some enteric species, but ...19816275785
a histidine decarboxylase gene encoded by the vibrio anguillarum plasmid pjm1 is essential for virulence: histamine is a precursor in the biosynthesis of anguibactin.we have identified and sequenced an hdc gene in the vibrio anguillarum plasmid pjm1 which encodes a histidine decarboxylase enzyme and is an essential component for the biosynthesis of anguibactin. the open reading frame corresponds to a protein of 386 amino acids with a calculated molecular mass of 44,259.69 da. the amino acid sequence has extensive homology with the pyridoxal-p-dependent histidine decarboxylases of morganella morganii, klebsiella planticola, and enterobacter aerogenes. tn3-hoh ...19957752899
characterization and sequence of phoc, the principal phosphate-irrepressible acid phosphatase of morganella morganii.phosphatase activities were investigated in morganella morganii, which is one of the few enterobacterial species producing high-level phosphate-irrepressible acid phosphatase activity (hpap phenotype), and the gene encoding the major phosphate-irrepressible acid phosphatase was cloned, sequenced, and its product characterized. using p-nitrophenyl phosphate as substrate, morganella produced a major phosphate-irrepressible acid phosphatase (named phoc) which is associated with the hpap phenotype, ...19948081499
ceftibuten: a review of antimicrobial activity, spectrum and other microbiologic features.ceftibuten is a new, orally administered cephalosporin with exceptional beta-lactamase stability and potency against commonly isolated gram-negative pathogens. more than 90% of recent enterobacteriaceae clinical isolates were inhibited by < or = 8 micrograms/ml of ceftibuten. in only five enteric species (citrobacter freundii, enterobacter aerogenes, enterobacter cloacae, morganella morganii, serratia marcescens) were more than 15% of strains resistant (minimal inhibitory concentrations (mic, wi ...19957567314
evaluation of different antimicrobial agents used as selective supplements for isolation and recovery of yersinia enterocolitica.seventeen antimicrobial agents were evaluated separately or in combination for their efficiency as selective supplements in a broth medium against six different serotypes of yersinia enterocolitica and 20 selected strains of different gram-negative bacteria. irgasan (dp300, 5-chloro-2-(2,4- dichlorophenoxy) phenol) at a concentration of 4 micrograms ml-1 inhibited the growth of most gram-negative bacteria with the exceptions of aeromonas hydrophila, morganella morganii, pseudomonas aeruginosa an ...19947928783
head and neck infections in pediatric cardiac transplant patients.a retrospective chart review was undertaken at columbia presbyterian medical center to assess the incidence, etiology and management of head and neck infections in pediatric cardiac transplant patients on immunosuppression. from june 1984 to february 1992, 59 cardiac transplants were performed on 57 pediatric patients. standard immunosuppressive therapy was used. thirteen of these patients died within three months of transplant and were not included. of the 44 patient charts reviewed, 82 head an ...19957628334
laboratory data which differentiate meropenem and imipenem.meropenem and imipenem are carbapenems which are distinguishable from all other currently available beta-lactam antibiotics by breadth of antibacterial spectrum and stability to beta-lactamases, but can be differentiated one from another. meropenem is relatively stable to human renal dehydropeptidase-i (dhp-i); it does not require to be co-administered with cilastatin and consequently, unlike imipenem, will be administered as a single agent. in vitro both meropenem and imipenem are active agains ...19957652504
proteus mirabilis amino acid deaminase: cloning, nucleotide sequence, and characterization of aad.proteus, providencia, and morganella species produce deaminases that generate alpha-keto acids from amino acids. the alpha-keto acid products are detected by the formation of colored iron complexes, raising the possibility that the enzyme functions to secure iron for these species, which do not produce traditional siderophores. a gene encoding an amino acid deaminase of uropathogenic proteus mirabilis was identified by screening a genomic library hosted in escherichia coli dh5 alpha for amino ac ...19957592338
the in-vitro activity of cp 99,219, a new naphthyridone antimicrobial agent: a comparison with fluoroquinolone agents.the in-vitro activity of a new fluoroquinolone, cp 99,219 was compared with that of ciprofloxacin, du 6859, sparfloxacin and levofloxacin. cp 99,219 showed generally similar in-vitro activity to the other compounds tested against the enterobacteriaceae (mic90 of all agents < 0.5 mg/l except morganella morganii). it was found to be more active than ciprofloxacin, sparfloxacin and levofloxacin against the strains of acinetobacter calcoaceticus tested (mic90 1 mg/l). cp 99,219 was found to be four- ...19957559198
purification and properties of crystalline 3-methylaspartase from two facultative anaerobes, citrobacter sp. strain yg-0504 and morganella morganii strain yg-0601.3-methylaspartase (3-methylaspartate ammonia-lyase, ec 4.3.1.2) from two facultative anaerobes from soil, citrobacter sp. strain yg-0504 and morganella morganii strain yg-0601, were purified and crystallized from their crude extracts. both of the citrobacter and morganella enzymes appeared to be a dimer of subunits of m(r) 40,000 and 44,000, respectively. the enzymes had similar enzymological properties: optimum ph for the deamination reaction of (2s,3s)-3-methylaspartic acid, substrate specific ...19957765982
in vitro antimicrobial activity of cefpirome against ceftazidime-resistant isolates from two multicenter studies.the in vitro activity of cefpirome against ceftazidime-resistant (mic > 16 mg/l) isolates from two multicenter studies was analyzed. the first investigation carried out in the usa, was an in vitro comparison of cefpirome and five third-generation cephalosporins in which more than 6,000 isolates were evaluated, including 97 enterobacteriaceae and 1,509 staphylococci resistant to ceftazidime. the second study was a multicenter international study (> 5,000 strains total) in which 160 ceftazidime-re ...19947813503
pore formation in artificial membranes by the secreted hemolysins of proteus vulgaris and morganella morganii.lipid-bilayer experiments were performed with the related hemolysins from proteus vulgaris and morganella morganii (hlya). the addition of the toxins to the aqueous phase bathing lipid-bilayer membranes composed of different lipids resulted in the formation of transient ion-permeable channels. membranes formed of pure lipids were rather inactive targets for the hemolysins as compared with lipid mixtures such as asolectin. the channels had several different substrates. the major open state had si ...19947510229
antibacterial activity and beta-lactamase stability of ceftazidime, an aminothiazolyl cephalosporin potentially active against pseudomonas aeruginosa.the in vitro activity and beta-lactamase stability of ceftazidime were evaluated against 700 gram-positive and gram-negative bacteria. ceftazidime was less active than penicillins or older cephalosporins against staphylococcus spp. and streptococcus spp., and it did not inhibit streptococcus faecalis, listeria, or anaerobic species. ceftazidime was as active as ceftizoxime and moxalactam and more active than cefoperazone against escherichia coli. klebsiella, and proteus mirabilis with minimal in ...19826805421
[multicenter evaluation of oral antibiotics: resistance behavior in 5 swiss centers].the susceptibility of 2196 fresh clinical isolates to twelve different oral compounds was assessed in five swiss microbiology institutions during summer 1992. a standardized microdilution system including all other material necessary was employed to assess the antibacterial activity of penicillin g, ampicillin, ampicillin + sulbactam, amoxycillin + clavulanic acid, cefadroxil, cephalexin, cefaclor, cefuroxime, cefetamet, doxycycline, erythromycin and clindamycin. the aminopenicillins (including ...19947939052
[antimicrobial activity of cefodizime against fresh clinical isolates].in order evaluate antimicrobial activities of cefodizime (cdzm), minimum inhibitory concentrations (mic's) of cdzm and other control drugs were determined against various clinical isolates, that were sent to our center from nation-wide medical institutions or were isolated and identified in our laboratory from various specimens of infected patients. the followings are a summary of the results: 1. bacterial species with no or few strains resistant to cephems including cdzm included streptococcus ...19938254888
[the antimicrobial activity of cefteram against recently clinically detected and isolated strains].in order to examine antibiotic activities of cefteram (cftm), its minimum inhibitory concentrations (mic's) and those of other cephem drugs were determined against clinically isolated strains received from july 1990 to june 1991 and from july 1992 to february 1993 from medical facilities throughout the country and against clinically isolated strains detected in our laboratory in samples from patients with various infectious diseases. the obtained results are summarized below. 1. no cftm-resistan ...19938254900
microbiological studies of abscesses complicating bothrops snakebite in humans: a prospective study.forty patients with abscesses at the site of bothrops bite were evaluated. ten brought the snake responsible for the bite, bothrops jararaca in all cases. on admission a sample was collected from each case for aerobic and anaerobic culture, and no abscesses drained spontaneously. none of the patients had received antibacterial therapy at this time. the bacteria most frequently isolated were morganella morganii (23 patients), providencia rettgeri (7) enterobacter sp. (4), escherichia coli (3), gr ...19947940580
[report of three cases of purple urine bag syndrome which occurred with a combination of both e. coli and m. morganii].purple urine bag syndrome is a rare phenomenon in which bags turns purple or blue following catheterization. this phenomenon was reported to occur by providencia stuartii in the presence of indicanuria. we reported herein three females above 75 years of age having a similar phenomenon. all were bedridden chronically and constipated. in these cases, no growth of p. stuartii was found on repeated urine culture, but escherichia coli and morganella morganii were concomitantly isolated during the blu ...19938320467
[susceptibility of proteus, morganella and providencia strains isolated from patients with urinary tract infections on bactericidal activity of normal human serum].usefulness of the test determining bactericidal activity of normal human serum was investigated with 50 strains of proteus, morganella and providencia isolated from patients with urinary tract infections (uti) and with 50 strains isolated from feces. it was found that strains from uti were more frequently resistant to the action of normal human serum (50% resistant) in comparison with strains isolated from feces (30% resistant). strains of proteus belonging to four species were differing greatly ...19938189801
human t helper cells reactive with somatic bacterial antigens belong to the th1 subset.the aim of this study was to characterize the cytokine secretion patterns of human t helper cells from healthy donors reactive with somatic antigens from various bacteria, the nematode anisakis and tetanus toxoid. from the peripheral blood of four healthy donors we have established 70 t cell lines reactive with antigens from yersinia, salmonella, morganella, klebsiella, serratia, escherichia, chlamydia, shigella, streptococcus, tetanus toxoid and anisakis, respectively. our results show that all ...19947997190
[a nationwide survey of antimicrobial susceptibilities of clinical isolates to antibiotics in japan (1988-1990)].this study was conducted to investigate susceptibilities of clinical isolates to antibacterial agents at 149 hospitals throughout japan from september to december in both 1989 and 1990. in this study, identifications and susceptibility testings were carried out at each hospital laboratory. the susceptibility testings were performed according to the disk diffusion method recommended by nccls. staphylococcus aureus and coagulase-negative staphylococci showed high or moderate resistance rates to be ...19938360981
analysis of intestinal flora of a patient with congenital absence of the portal vein.a 14-year-old female patient, admitted for a closer examination of liver tumour (hepatocellular adenoma), was diagnosed as having a congenital absence of the portal vein. the blood ammonia level (approximately 120 micrograms dl-1) in the superior mesenteric vein was markedly low compared to the normal value of 300-350 micrograms dl-1 in the portal vein. the decreased ammonia concentration and urease activity of the patient's faeces were demonstrated. the dominant intestinal flora in the faeces o ...19938364525
comparative in-vitro activity of biapenem against enterobacteria with beta-lactamase-mediated antibiotic resistance.the effects of enterobacterial beta-lactamases were studied for biapenem (l627), a new carbapenem. susceptibility tests were performed for isogenic mutant series of citrobacter freundii, enterobacter cloacae, morganella morganii, serratia marcescens and proteus vulgaris which varied only in chromosomal beta-lactamase expression. beta-lactamase-derepressed organisms in these series were as susceptible as beta-lactamase-inducible strains to biapenem; beta-lactamase-basal mutants were up to eight-f ...19948040111
bactericidal activity of normal human serum against morganella, proteus, and providencia strains.the susceptibility od proteus, providencia, and morganella strains to bactericidal action of human serum was examined. the percentage of survival was determined after one and three hours incubation with 50% human serum. the susceptible strains were treated by serum preparations with blocked classical or alternative complement activation pathways as well as with lysozyme removed. following mechanisms of the bactericidal action of serum were found: complement activated by the classical or alternat ...19957660859
spontaneous bacterial empyema and peritonitis caused by morganella morganii. 19948113596
comparative microbiological activity and pharmacokinetics of cefprozil.in vitro studies on the activity of cefprozil have been conducted in europe and north america. against gram-negative bacilli, cefprozil and cefaclor are at least two to four times more active than cephalexin. cefixime is more active against these organisms. against gram-positive cocci, cefprozil is at least two to four times more active than cefaclor and cephalexin; cefixime has limited gram-positive activity, and is particularly inactive against staphylococci (mic90 32 mg/l). cefprozil is highl ...19947889957
in vitro activity of cefpirome against beta-lactamase-inducible and stably derepressed enterobacteriaceae.most members of the enterobacteriaceae and pseudomonas aeruginosa possess an inducible chromosomal class i beta-lactamase. bacterial strains which produce high levels of beta-lactamase constitutively can be isolated from infections; these derepressed mutants are responsible for resistance to third-generation cephalosporins and ureidopenicillins. minimum inhibitory concentrations of cefpirome, a fourth-generation cephalosporin, and other beta-lactam antibiotics were determined for a series of mut ...19947956454
toc-39, a novel parenteral broad-spectrum cephalosporin with excellent activity against methicillin-resistant staphylococcus aureus.toc-39, a new parenteral cephalosporin, is a hydroxyimino-type cephem antibiotic with vinylthio-pyridyl moiety at the 3 position. toc-39 was evaluated for antibacterial activity against various clinically isolated strains. toc-39 had excellent activity, stronger than that of methicillin, oxacillin, the cephalosporins tested, imipenem, gentamicin, minocycline, tobramycin, ofloxacin, and ciprofloxacin against methicillin-resistant staphylococcus aureus (mrsa) and had an mic comparable to that of v ...19957625799
comparative antibacterial activity of l-695,256, a carbapenem active against methicillin-resistant staphylococci.the activity of a new prototype carbapenem, l-695,256, against clinical isolates of gram-positive and gram-negative aerobes was studied in vitro by agar dilution. l-695,256 was highly active against methicillin-resistant and -susceptible isolates of staphylococci (mics, 0.016 to 2 micrograms/ml) and against penicillin-resistant pneumococci (mics, 0.016 to 0.064 micrograms/ml), irrespective of penicillin susceptibility. activity against members of the family enterobacteriaceae was less than that ...19957625810
pore-formation by escherichia coli hemolysin (hlya) and other members of the rtx toxins family.escherichia coli hemolysin (hlya) is a major cause of e. coli virulence. it lyses erythrocytes by a colloid osmotic shock due to the formation of hydrophilic pores in the cell wall. the size of these channels can be estimated using osmotic protectant of increasing dimensions. to show that the formation of pores does not depend critically on the osmotic swelling we prepared resealed human erythrocyte ghosts loaded with a fluorescent marker. when attacked by hlya the internal marker was released, ...19948160187
hospital cluster epidemic with morganella morganii.a cluster epidemic of 13 morganella morganii infections involving 11 patients occurred over a 3-month period in 1977. this epidemic was unusual in that it involved four services and five hospital floors. the outbreak was effectively terminated when strict asceptic techniques were reinforced.19817309851
prediction of bacterial susceptibility to cefpodoxime by using the ceftriaxone minimum inhibitory concentration result.the cross-resistance or cross-susceptibility of cefpodoxime and ceftriaxone for 3700 strains of enterobacteriaceae, oxacillin-susceptible staphylococci, streptococcus spp., haemophilus influenzae, moraxella catarrhalis, and neisseria gonorrhoeae was evaluated. with the exception of tests with enterobacter spp. and morganella morganii, the ceftriaxone minimum inhibitory concentration (mic) result interpretive criteria predicted bacterial susceptibility (or resistance) to cefpodoxime with an accep ...19938112047
in vitro activity of subinhibitory concentrations of quinolones on urea-splitting bacteria: effect on urease activity and on cell surface hydrophobicity.the effect of subinhibitory concentrations of ciprofloxacin, lomefloxacin, norfloxacin, ofloxacin, and sparfloxacin on urease activity and on cell surface hydrophobicity of urea-splitting bacteria was examined. quinolones at 0.5 mics demonstrated variable effects on bacterial-urease activity. norfloxacin inhibited enzyme activity in proteus vulgaris and proteus mirabilis, while other quinolones had no effects. in morganella morganii, sparfloxacin and ciprofloxacin enhanced urease activity, parti ...19957844396
alpha-keto acids are novel siderophores in the genera proteus, providencia, and morganella and are produced by amino acid deaminases.growth promotion and iron transport studies revealed that certain alpha-keto acids generated by amino acid deaminases, by enterobacteria of the proteus-providencia-morganella group (of the tribe proteeae), show significant siderophore activity. their iron-binding properties were confirmed by the chrome azurol s assay and uv spectra. these compounds form ligand-to-metal charge transfer bands in the range of 400 to 500 nm. additional absorption bands of the enolized ligands at 500 to 700 nm are re ...19938478334
[clinical and laboratory significance of inducible beta-lactamases].many species of bacteria have inducible expression of beta-lactamase and the enzyme production in these bacteria is normally held at a low level by a repressor mechanism, but in the presence of a beta-lactamase inducer this repression is lifted and enzyme production is greatly increased. inducible synthesis of beta-lactamase was first described for the gram-positive organism bacillus licheniformis. after that inducible expression of beta-lactamase was discovered in gram-negative bacteria like en ...19958643019
comparative in vitro activity of fk-037, a new cephalosporin antibiotic.the in vitro activity of fk-037, a novel parenteral oxime-type cephalosporin, was compared with that of cefepime, cefpirome, ceftazidime, imipenem, and gentamicin against a total of 668 recent clinical isolates. minimum inhibitory concentrations were determined by a standard agar dilution procedure, and all isolates were tested at two inocula (10(4) and 10(6) colony forming units). fk-037 inhibited 90% of isolates of escherichia coli, klebsiella species, proteus mirabilis, p. vulgaris, morganell ...19947867295
morganella morganii meningitis in a patient with aids. 19947884233
in vitro antimicrobial activity of fluoroquinolones against clinical isolates obtained in 1989 and 1990.the in vitro activity of nine fluoroquinolones, enoxacin, norfloxacin, ofloxacin, ciprofloxacin, lomefloxacin, tosufloxacin, sparfloxacin, fleroxacin and levofloxacin, and two earlier quinolones, nalidixic acid and pipemidic acid, against 1,346 bacterial strains isolated clinically between 1989 and 1990, was evaluated by agar dilution method. the bacteria studied were staphylococcus aureus (including methicillin-susceptible and -resistant strains), staphylococcus epidermidis, enterococcus specie ...19937911351
comparison of the antibody responses to the 77 klebsiella capsular types in ankylosing spondylitis and various rheumatic diseases.the production of antibodies to klebsiella capsular polysaccharides was measured in sera from either hla-b27-positive (hla-b27+) or hla-b27-negative (hla-b27-) patients with classical ankylosing spondylitis (n = 54). these sera were compared with sera from patients with various rheumatic diseases (n = 82) and hla-b27+ or hla-b27- healthy individuals (n = 85). all sera were analyzed by means of an enzyme-linked immunosorbent assay specific to each of the 77 klebsiella serotypes. the sera from hla ...19947927763
[in vitro antibacterial activity of isoxazolyl++ naphthoquinones. i].the in vitro antibacterial activity of 2-hydroxy-n-(3,4-dimethyl-5-isoxazolyl) 1,4 naphthoquinone-4-imine (i) and three of this derivatives against staphylococcus aureus, escherichia coli, pseudomonas aeruginosa, proteus mirabilis y morganella morganii was investigated. from the four naphthoquinone-imine studied, compound i exhibited activity against s. aureus. this effect was observed even in oxygen atmosphere with 5% co2 and in the presence of human albumin. the development of drug-resistant s ...19938140244
regulation of the escherichia coli s10 ribosomal protein operon by heterologous l4 ribosomal proteins.we have cloned the l4 ribosomal protein genes from morganella morganii and haemophilus influenza. the sequences of these genes were compared with published sequences for escherichia coli, yersinia pseudotuberculosis, and bacillus stearothermophilus. all five of these l4 genes were expressed in e. coli and shown to function as repressors of both transcription and translation of the e. coli s10 operon. possible implications for regulation of r-protein synthesis in species other e. coli are discuss ...19958722027
extent of peptidoglycan o acetylation in the tribe proteeae.the degree of peptidoglycan o acetylation in 18 strains of the different genera of the tribe proteeae (proteus, providencia, and morganella) has been determined by high-performance liquid chromatography-based organic acid analysis of mild-base-released acetic acid and quantitation of peptidoglycan concentrations by simultaneous amino sugar-amino acid analysis using high-performance anion-exchange chromatography with pulsed amperometric detection. the n,o-diacetylmuramyl content of all isolated a ...19938331084
[value of media containing chromogenic substrates for the identification and the listing of urinary bacteria].performance in terms of enumeration, growth and identification with a new culture medium (cps id2, biomérieux) was evaluated using 405 urine samples and 244 collection strains. the cps id2 medium contains chromogenic substrates enabling the detection of 4 bacterial enzymes which leads to the identification of colonies: escherichia coli, proteus mirabilis, proteus-morganella-providencia and enterococci. no discrepancies in the enumeration were observed with the collected strains and urine samples ...19958746095
comparative in vitro activity of biapenem, a new carbapenem antibiotic.biapenem is a new carbapenem antibiotic with high stability to human renal dehydropeptidase i. its in vitro activity was compared with that of imipenem, meropenem, ceftazidime, ceftriaxone, piperacillin and gentamicin against a total of 650 recent clinical isolates. mics were determined by a standard agar dilution procedure and all isolates were tested at two inocula (10(4) and 10(6) cfu). biapenem inhibited 90% of isolates of escherichia coli, klebsiella spp., proteus mirabilis, proteus vulgari ...19938354306
identification and typing of proteus penneri and proteus vulgaris biogroups 2 and 3, from clinical sources, by computerized analysis of electrophoretic protein patterns.seventy-six strains of the proteus vulgaris complex (pr. penneri and pr. vulgaris biogroups 2 and 3) were characterized by one-dimensional sds-page of cellular proteins. the protein patterns were highly reproducible. the strains came from various countries and were mainly of human origin: urine (28), respiratory tract (13), wounds (8), faeces (7), blood (3), miscellaneous sources (6) and unknown sources (11). the patterns of these strains, together with those of the type strains of seven morgane ...19938300450
[clinical study of a new injectable cephem, fk037, for acute bacterial prostatitis].fk037, a new injectable cephem antibiotic, was administered in the treatment of 13 acute bacterial prostatitis (mean age 53.5, range 30-79), and its effectiveness and safety were evaluated. the human prostatic fluid (pf) concentration of fk037 on 7 specimens 1 hour after 1 g i.v.d., was in the range of 0.87-7.47 micrograms/ml (mean +/- sd, 3.43 +/- 2.23 micrograms/ml), whereas, the serum concentration averaged 45.3 +/- 2.88 micrograms/ml, the ratio of pf/serum consequently being 0.08 +/- 0.05. i ...19947863869
[antibacterial activity of aztreonam against clinical isolates].to evaluate the antibacterial activity of a monobactam antibiotic, aztreonam (azt), mics of azt and other antibiotics against clinical isolates collected at 36 participating institutions after january 1992 were determined using the agar plate dilution method (size of inoculum, 10(6) cfu/ml) according to the japan society of chemotherapy standard. the antibiotics that were tested along with azt included piperacillin (pipc), cefoperazone (cpz), and amikacin (amk). azt was found to be more active a ...19948051793
penetration of topically applied ciprofloxacin, norfloxacin, and ofloxacin into the aqueous humor.to determine the intraocular penetration of topically applied fluoroquinolone antibiotics into aqueous humor.19948190478
resistance to third-generation cephalosporins in barbados.resistance to third-generation, or extended-spectrum, cephalosporins caused by induction of class i beta-lactamases has been reported rarely from developing countries. seven isolates of cephalosporin-resistant gram-negative rods were recovered recently from urine, burns and ulcers in the queen elizabeth hospital, barbados. the isolates were identified as acinetobacter calcoaceticus (2), citrobacter freundii (1), enterobacter cloacae (1), morganella morganii (1), providencia stuartii (1) and prot ...19938367967
multicentre survey of the comparative in-vitro activity of piperacillin/tazobactam against bacteria from hospitalized patients in the british isles.twenty-nine british and irish hospitals each collected up to 300 bacterial isolates from in-patients. the organisms were identified by an appropriate api system or, for staphylococci, by their gram and coagulase reactions. disc susceptibility tests were performed. isolates that gave zones < or = 25 mm to piperacillin/tazobactam (75 micrograms + 10 micrograms) discs were sent to a central laboratory for re-examination and determination of mic, together with a sample of the more susceptible organi ...19938226427
neonatal brain abscess caused by morganella morgagni. 19957742461
compositional analysis of peptidoglycan by high-performance anion-exchange chromatography.a high-performance anion-exchange chromatography method with pulsed-amperometric detection has been developed for the simultaneous analysis of both amino acids and amino sugars and applied to the compositional analysis of peptidoglycan hydrolysates. chromatography of the acid hydrolysis products was performed on a carbopac pa-1 anion-exchange column, with pulsed-amperometric detection. complete resolution of the two amino sugars (glucosamine and muramic acid) and eight of the nine amino acids (a ...19938214575
study of enterobacteriaceae throughout the manufacturing and ripening of hard goats' cheese.the evolution of the counts and the species of enterobacteriaceae as well as some physico-chemical parameters (ph, aw and nacl and moisture contents) during manufacturing and ripening of a hard spanish goats' cheese of the armada-sobado variety were studied. enterobacteriaceae (mean log counts 4.45 g-1 in milk) increased 0.71-2.18 log units in curd and afterwards decreased until they disappeared after 2-4 weeks of ripening. this premature disappearance seems to be due to the decrease in aw value ...19938244902
identification and characterization of phon-sf, a gene on the large plasmid of shigella flexneri 2a encoding a nonspecific phosphatase.a gene encoding a nonspecific phosphatase, named phon-sf, was identified on the large virulence plasmid (pmysh6000) of shigella flexneri 2a ysh6000. the phosphatase activity in ysh6000 was observed under high-phosphate conditions. however, it was found that low-phosphate conditions induced a slightly higher level of activity. the nucleotide sequence of the phon-sf region cloned from pmysh6000 possessing the phon-sf gene encoded 249 amino acids with a typical signal sequence at the n terminus. th ...19968755883
t lymphocyte responses to antigens of gram-negative bacteria in pyelonephritis.we showed previously that large numbers of t lymphocytes accumulate within a few days in the kidneys of rats with ascending pyelonephritis induced with escherichia coli or pseudomonas aeruginosa. cd4+ t cells propagated from the lesions exhibited mhc-restricted proliferative responses to formalin-fixed bacteria of the species used to induce infection. in the present study we investigated further the nature of the antigens responsible for the t cell proliferation and studied the ability of differ ...19938403542
[in vitro antibacterial activity of a new parenteral penem, sulopenem].eighty percent minimum inhibitory concentrations (mic80) of sulopenem against clinically isolated 12 to 80 strains of each of different bacteria were as follows: methicillin-susceptible staphylococcus aureus (mssa): 0.20 micrograms/ml, methicillin-resistant s. aureus (mrsa): 50 micrograms/ml, coagulase-negative staphylococci: 3.13 micrograms/ml, streptococcus pyogenes: < or = 0.013 microgram/ml, streptococcus pneumoniae: < or = 0.013 microgram/ml, beta-streptococci: 0.05 microgram/ml, enterococc ...19968786624
the activity of cefpirome and ten other antibacterial agents against 2858 clinical isolates collected from 20 centres.two thousand eight hundred and fifty-eight aerobic clinical isolates of enterobacteriaceae, pseudomonas species, staphylococci, streptococci and haemophilus species were collected in 19 geographically separated centres in the uk and one in ireland. the identity of each isolate was confirmed at southmead hospital and the mic of cefpirome, cefotaxime, ceftazidime, cefuroxime, cephradine, amoxycillin, piperacillin, imipenem, gentamicin, ciprofloxacin and trimethoprim was determined by an agar dilut ...19938486569
comparative antibacterial activity of the aminothiazolyl cephalosporin ru 29,246.a total of 1,007 clinical isolates from a tertiary care center were tested against ru 29,246, ampicillin, cephalothin, cefoxitin, ceftazidime, augmentin, oxacillin, piperacillin, gentamicin, amikacin and vancomycin. bacteria tested consisted of 479 strains of enterobacteriaceae, 64 pseudomonads, 18 xanthomonas, 42 other gram-negative bacilli, 56 enterococci and 348 isolates of staphylococci. ru 29,246 showed excellent in vitro activity inhibiting > 90% of escherichia coli, klebsiella pneumoniae, ...19938508687
interpretive accuracy of the disk diffusion method for testing newer orally administered cephalosporins against morganella morganii.eight newer orally administered cephems (cefdinir, cefetamet, cefixime, cefpodoxime, cefprozil, ceftibuten, cefuroxime, and loracarbef) were tested against 100 clinical strains of morganella morganii to determine the extent of serious interpretive very major (false-susceptible) errors when current criteria for the disk diffusion test are applied. agar dilution mics and disk diffusion tests were performed as recommended by the national committee for clinical laboratory standards (villanova, pa.) ...19938253998
[comparison of mics of new quinolones obtained using agar-dilution and broth-microdilution procedures].minimum inhibitory concentrations (mic) of new quinolones against both gram-positive and gram-negative bacteria obtained using agar-dilution and broth-microdilution procedures were compared. a primary regression curve and a correlation coefficient (r) between 2 mics for each of ofloxacin, ciprofloxacin, tosufloxacin, sparfloxacin or balofloxacin were calculated. for the 5 quinolones, average correlation coefficients were 0.891 for the gram-positive bacteria tested, and 0.865 for the gram-negativ ...19957752452
[antimicrobial susceptibility patterns of the proteeae in japan, 1989].we discussed the antimicrobial susceptibilities of proteeae isolated in japan, 1989. eight hundred six clinical isolates were collected from 47 hospitals. these were comprised of 431 strains of proteus mirabilis, 155 proteus vulgaris, 154 morganella morganii, 44 providencia rettgeri and 22 providencia stuartii. antibiotics tested in this study were 2 penicillins, 5 cephems, 1 carbapenem and 2 aminoglycosides. the mic's were determined using the standard method of the japan society of chemotherap ...19938515560
the most frequently occurring aminoglycoside resistance mechanisms--combined results of surveys in eight regions of the world. the aminoglycoside resistance study groups.aminoglycoside-resistant isolates from different patients were collected in 149 hospitals in eight regions of the world. aminoglycoside resistance mechanisms were determined in 11,079 of these isolates by the correlation of resistance phenotypes to 12 aminoglycosides and dna hybridisation with up to 19 resistance genes. a very large diversity of different resistance mechanisms was found. for example, in escherichia-morganella-proteus-salmonella-shigella, at total of 53 different mechanisms was f ...19958622108
the changing nature of aminoglycoside resistance mechanisms and the role of isepamicin--a new broad-spectrum aminoglycoside. the aminoglycoside resistance study groups.aminoglycoside resistance mechanisms from recent studies were compared with those found in earlier studies in the usa and europe for three pathogen groups. among citrobacter-enterobacter-klebsiella, four single mechanisms (aac(3)-ii, aac(3)-i, ant(2")-i and aac(6')-i were found in all studies, but the most recent studies showed a significant increase in combinations of aac(6')-i with the other common mechanisms. since aac(6')-i confers resistance to tobramycin, netilmicin and amikacin, combinati ...19958622109
morganella morganii pericarditis after resolvent splenectomy for immune pancytopenia following allogeneic bone marrow transplantation for acute lymphoblastic leukemia. 19958645811
in vitro activity of e-4868, a new fluoroquinolone with a 7-azetidin ring, compared with ciprofloxacin, ofloxacin and fleroxacin.e-4868, (-)-7[3-(r)-amino-2-(s)-methyl-1-azetidinyl]-1-(2,4- difluorophenyl)-1,4-dihydro-6-fluoro-4-oxo-3-quinolinecarboxylic acid, is a new fluoroquinolone with a 7-azetidin ring substituent. the in vitro activity against clinical isolates was compared with that of ciprofloxacin, ofloxacin and fleroxacin. in general, activity of e-4868 against aerobic and facultative anaerobic gram-negative bacilli was equal to or slightly less active than ciprofloxacin with the exception of morganella morganii ...19958529525
belgian multicentre study on the in vitro activity of cefepime against gram-negative bacilli.the in vitro activity of cefepime has been compared with that of cefotaxime, ceftazidime, aztreonam, and piperacillin against 1826 enterobacteriaceae including 537 inducible enterobacteriaceae (enterobacter spp., serratia spp., citrobacter spp,. morganella morganii) and 572 non-fermenters, including 401 pseudomonas aeruginosa and 111 acinebacter spp. isolated from hospitalized patients in 28 belgian hospitals. overall, cefepime was found substantially more active than the third-generation cephal ...19968669160
determinants of the activity of beta-lactamase inhibitor combinations.inhibitor combinations provide one strategy to overcome beta-lactamase-mediated resistance. their success depends, obviously, on the inhibitor being able to bind and inactivate the beta-lactamase molecules. clavulanate, sulbactam and tazobactam are irreversible inactivators of many beta-lactamases, forming covalent complexes which resist hydrolysis. 'suicide' kinetics are seen with some, but not all, enzymes. all three compounds inactivate staphylococcal penicillinase, the chromosomal beta-lacta ...19938449836
influence of spontaneous and inducible beta-lactamase production on the antimicrobial activity of recently developed beta-lactam compounds.the activity of 9 recently developed beta-lactam compounds was evaluated in 185 ampicillin-resistant isolates of enterobacteriaceae. moreover, in all strains, spontaneous and inducible beta-lactamase production was quantified and correlated with the minimal inhibitory concentration (mic) of each compound. in most species, no correlation could be observed between spontaneously produced beta-lactamase and the mics, with the only exceptions of serratia spp. and morganella morganii isolates for meth ...19846610539
ferric rhizoferrin uptake into morganella morganii: characterization of genes involved in the uptake of a polyhydroxycarboxylate siderophore.iron uptake in morganella morganii, mediated by the fungal siderophore rhizoferrin, was studied. a mud1 insertion mutant devoid of growth on ferric rhizoferrin was complemented by a chromosomal dna fragment of m. morganii that encoded an outer membrane protein and a periplasmic protein named ruma and rumb (for rhizoferrin uptake into morganella spp.), respectively. ruma and rumb have the same transcription polarity and are probably cotranscribed from an iron-regulated promoter upstream of ruma. ...19968550472
biochemical investigations of biogroups and subspecies of morganella morganii.we determined the subspecies and biogroup designations for 73 strains of morganella morganii principally recovered from routine clinical specimens. on the basis of trehalose fermentation, 90% of all strains were identified as m. morganii subsp. morganii (trehalose negative), while the remaining 10% were designated m. morganii subsp. sibonii (trehalose positive). using three tests (ornithine decarboxylase [odc] and lysine decarboxylase [ldc] activities and susceptibility to tetracycline), we dete ...19968748284
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