Publications

TitleAbstractYear
Filter
PMID(sorted ascending)
Filter
in vitro activity of hre 664, a penem antibiotic.hre 664, a new penem antibiotic, inhibited 90% of escherichia coli, klebsiella, citrobacter diversus, proteus mirabilis, proteus vulgaris, salmonella, shigella, providencia, aeromonas, and morganella at less than or equal to 2 micrograms/ml but was considerably less active than cefotaxime, ceftazidime, and imipenem. it did not inhibit pseudomonas aeruginosa (mic greater than 128 micrograms/ml). hre 664 inhibited enterobacter spp., citrobacter freundii, and serratia marcescens at 1-8 micrograms/m ...19902279381
the role of microorganisms in psoriasis.the microflora of 297 psoriasis patients was extensively examined. throat, urine, and skin surfaces from scalp, ears, chest, face, axillary, submammary, umbilical, upper back, inguinal crease, gluteal-fold, perirectal, vaginal, pubis, penis, scrotal, leg, hands, feet, finger, and toenail areas were cultured for aerobic bacteria, yeast, and dermatophytes. antibody levels to streptococcal enzymes were performed (streptolysin-o, dnase-b, hyaluronidase, streptozyme). giemsa smears and koh preparatio ...19902285571
[susceptibilities of clinical bacterial isolates to antimicrobial agents. a study mainly focused on imipenem. reported by the research group for testing imipenem susceptibility on clinical isolates].this study was conducted to investigate susceptibilities of clinical bacterial isolates to imipenem (ipm) and other antibacterial agents at 64 hospital laboratories throughout japan from september to december of 1988. in this study, identification and susceptibility testing were carried out at each laboratory and the tests were performed according to the disk dilution method recommended by nccls in which susceptibilities are classified into "s", "ms", "i" and "r". ipm showed markedly high in vit ...19902287060
[clinical and diagnostic aspects of infective nephrobronchial fistulae].after reviewing all of our hospital admittances, this paper presents two cases of nephrobronchial fistula (nbf) occurring in two patients, one with renal abscess-like granulomatous pathology and one with xantogranulomatous pyelonephritis (xgp). after commenting on these cases and including iconography, among which a fistulography, very rare in this type of cases, should be emphasized, the coincidence of the three microorganisms (and the presence of morganella morganii) in lung cultures, and kidn ...19902288248
in vitro activity against clinically important gram-positive and gram-negative bacteria of sulbactam, alone and in combination with ampicillin, cefotaxime, mezlocillin, and piperacillin.the in vitro effects of the single agents, and the synergistic/antagonistic action of three different combinations of ampicillin (amp, cas 69-53-4), cefotaxime (ctx, cas 63527-52-6), mezlocillin (mez, cas 51481-65-3), and piperacillin (pip, cas 61477-96-1) with the beta-lactamase inhibitor sulbactam (sul, cas 68373-14-8) were determined against 675 gram-positive and gram-negative, both aerobic and anaerobic bacteria. all the combinations of sulbactam and the antibiotics (1: 1, 1:2 and 1:4) exhib ...19902291754
in-vitro activity of cefpodoxime against 1834 isolates from domiciliary infections at 20 uk centres.a total of 1834 non-copy, general practice or outpatient isolates were collected by 20 hospital laboratories within the british isles, and identified and tested for susceptibility to nine antimicrobial agents available by oral administration at one centre. against enterobacteriaceae cefpodoxime was the most active beta-lactam agent tested, the mic90s being: for escherichia coli 1.0 mg/l, for proteus mirabilis 1.0 mg/l, for citrobacter spp. 2.0 mg/l, and for enterobacter spp., serratia spp., morg ...19902292533
evolution of aromatic amino acid biosynthesis and application to the fine-tuned phylogenetic positioning of enteric bacteria.a comprehensive phylogenetic tree for virtually the entire assemblage of enteric bacteria is presented. character states of aromatic amino acid biosynthesis are used as criteria, and the results are compared with partial trees based upon sequencing of 16s rrna, 5s rrna, and tryptophan leader peptide. three major clusters are apparent. enterocluster 1 possesses a gene fusion (trpg-trpd) encoding anthranilate synthase: anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase of tryptop ...19902298692
purification and n-terminal analysis of urease from helicobacter pylori.urease of helicobacter pylori (formerly campylobacter pylori) is believed to represent a critical virulence determinant for this species. ammonia generated by hydrolysis of urea may protect the acid-sensitive bacterium as it colonizes human gastric mucosa. an h. pylori strain, cultured from a gastric biopsy of a patient with complaints of abdominal pain and a history of peptic ulcer disease, was isolated on selective medium and cultured in mueller-hinton broth supplemented with 4% fetal calf ser ...19902318539
diverse potential of beta-lactamase inhibitors to induce class i enzymes.the ability of various beta-lactamase inhibitors to induce class i beta-lactamases was assessed. clavulanate was the most active compound, inducing morganella morganii, aeromonas caviae, and enterobacter aerogenes over a broad concentration range and citrobacter freundii, pseudomonas aeruginosa, and serratia marcescens at high concentrations. disk approximation tests paralleled these results, with clavulanate, but not sulbactam or tazobactam, antagonizing the activity of several beta-lactams aga ...19902327752
the in-vitro activity of ceftibuten against 475 clinical isolates of gram-negative bacilli, compared with cefuroxime and cefadroxil.the in-vitro activity of ceftibuten was compared with cefuroxime and cefadroxil against 475 clinically-significant, epidemiologically-distinct isolates of gram-negative bacilli: 170 from blood, 212 from urine and 93 from a supplementary collection of multiply-resistant strains known to have resistance plasmids, to have caused sporadic or epidemic nosocomial infection, or both. ceftibuten mics ranged from 0.003 to greater than 32 mg/l, with a modal mic of 0.01 mg/l: 95% of all isolates had ceftib ...19902329100
morganella morganii urease: purification, characterization, and isolation of gene sequences.morganella morganii, a very common cause of catheter-associated bacteriuria, was previously classified with the genus proteus on the basis of urease production. m. morganii constitutively synthesizes a urease distinct from that of other uropathogens. the enzyme, purified 175-fold by passage through deae-sepharose, phenyl-sepharose, mono-q, and superose 6 chromatography resins, was found to have a native molecular size of 590 kilodaltons and was composed of three distinct subunits with apparent m ...19902345135
direct introduction of a formamido group into the 7 alpha (6 alpha)-position of cephalosporins (penicillins).a novel direct introduction of a formamido group into the 7 alpha (6 alpha)-position of cephalosporins (penicillins) was achieved by treatment of 7 beta (6 beta)-[(3,5-di-tert-butyl-4-oxo-2,5-cyclohexadien-1- ylidene)methylimino]cephem (penam) esters with n,n-bis(trimethylsilyl)formamide, followed by deblocking with girard reagent t to give the corresponding 7 alpha (6 alpha)-formamido-7 beta (6 beta)-amino derivatives. three 7 alpha-formamidocephalosporins were prepared by the conventional n-ac ...19902387776
[antigenic characteristics of standard strains of providencia rettgeri (o- and h-antigens)].additions and changes have been introduced into the existing antigenic diagnostic scheme of p. rettgeri on the basis of the study of the antigenic structure of standard strains from foreign collections: new, formerly unknown varieties of somatic and flagellar antigens (o35, o36, h27, h28) have been discovered, the complex of antigenic factors for h-antigens 7, 10, 23, 27 has been discovered. strains 958 (36 : 28) and 979 (16 : 27a, 23b, 2a), previously classified with the genus morganella, have ...19852416153
bacterial lysis of fibrin seal in vitro.we performed an in vitro study to determine whether certain bacteria may lyse a commercially available fibrin seal (beriplast, behringwerke, marburg, frg). fibrinogen solution was mixed with actively growing bacterial cultures, and thrombin was added. during 20 days of incubation at 37 degrees c complete lysis was observed with a number of different bacteria, however, at different rates. complete lysis within 1-5 days was observed for the following species (number of strains in parentheses): str ...19882456934
haemolytic activity of morganella morganii strains.haemolytic activity on solid and liquid media of 103 morganella morganii strains isolated from clinical sources was investigated. the ability to produce haemolysin was found in 42.7% of strains. all strains capable to produce haemolysin on blood agar media also revealed haemolytic activity in some liquid media. haemolysins were found in the supernatants and filtrates of the cultures in peptone water but not in brain heart infusion and trypticase soy broth. the maximal titer of haemolysin was obs ...19882462333
[evaluation of sen-sir, a new microsystem for the identification and determination of bacterial sensitivity].the use of semiautomatic methods for identification and study of bacterial sensitivity to antimicrobials is increasingly widespread in clinical microbiology. in the present study, the evaluation of a new micromethod (sen-sir, bbl) for the identification and determination of bacterial sensitivity is reported. 115 clinical isolates of enterobacteria, 10 strains of acinetobacter calcoaceticus and 57 gram positive cocci, previously identified as belonging to the geni staphylococcus and streptococcus ...19892490681
[urease activity of bacteria in urine].urea splitting bacteria are related to the formation of struvite or apatite. we investigated the urease activity of bacteria by two methods; the direct measurement of urease activity of viable bacteria and sonicated bacteria from amounts of ammonia by the indophenol method, and the measurement of urease activity by alkalization of infected urine. proteus mirabilis and pseudomonas aeruginosa had moderate activity of urease, and morganella morganii and staphylococcus epidermidis had the most power ...19892500012
[investigations on the etiology of sepsis by using an experimental mouse model with leukocytopenia. 2. the role of the reticuloendothelial system in the etiology of bacteremia].it has been recognized by clinical data that most of sepsis occurring in the immunocompromised host are endogenous infection. in recent years, we have investigated the mechanism of these bacteremia and sepsis by experimental studies using neutropenic mice treated with cyclophosphamide. and we evidenced that most pathogens causing bacteremia originated in the intestinal flora of the host. it has been shown that bacteria causing bacteremia were divided into two main groups, causing systemic bacter ...19892507683
comparative in vitro activity of sm7338, a new carbapenem antimicrobial agent.the comparative in vitro activity of sm7338 was tested against 670 routine clinical isolates and 130 cefoperazone-resistant isolates of bacteria by agar dilution methods. sm7338 was at least as active as imipenem against gram-negative organisms but was slightly less active against gram-positive organisms. sm7338 was particularly active against members of the family enterobacteriaceae, with mics for 90% of strains of less than or equal to 0.125 micrograms/ml for all species tested. differences in ...19892508543
the postantibiotic effect of meropenem and imipenem on selected bacteria.controlled experiments were conducted to determine the in-vitro postantibiotic effect (pae) of meropenem and imipenem on ten selected bacteria representative of medically important species: staphylococcus aureus (2). pseudomonas aeruginosa (4), escherichia coli (1), serratia marcescens (1), morganella morganii (1), and providencia stuartii (1). the pae was determined by comparing serial colony counts of cultures recovering from exposure to drug concentrations at 4 x mic for 1.5 h with the counts ...19892509416
in-vitro activity of meropenem imipenem, the penem hre 664 and ceftazidine against clinical isolates from west germany.the antibacterial activity in vitro of meropenem was compared with another carbapenem, imipenem, the penem hre 664, and ceftazidime. mics were not influenced by ph nor by inoculum size below 5 x 10(5) cfu/ml: higher inocula caused a modest increase in mic. cation supplementation of mueller-hinton broth was without effect. meropenem was more active than imipenem and the other comparative agents against the majority of gram-negative species (in particular proteus, providencia, morganella, haemophi ...19892509418
in vitro and in vivo efficacy of ytr-830h and piperacillin combinations versus beta-lactamase-producing bacteria.ytr-830h, a beta-lactamase inhibitor, is a non-amino penicillanic sulfone. in vitro synergistic activity with piperacillin was determined for 226 beta-lactamase producing clinical cultures. combination of piperacillin: ytr in ratios of 2:1, 4:1, and 8:1 were highly effective vs escherichia coli, proteus, providencia, morganella, staphylococcus, and bacteroides. minimum inhibitory concentrations (mics) of piperacillin were reduced from the resistant to susceptible range. the higher ratios were le ...19892552030
comparative in vitro activities of piperacillin-tazobactam and ticarcillin-clavulanate.the in vitro activities of ticarcillin, piperacillin, clavulanic acid, tazobactam, ticarcillin-clavulanate, and piperacillin-tazobactam against 819 bacterial isolates were compared. the two beta-lactamase inhibitors, clavulanic acid and tazobactam, had little useful antibacterial activity but enhanced the activities of the penicillins against beta-lactamase-producing strains of haemophilus influenzae, branhamella catarrhalis, and methicillin-susceptible staphylococcus aureus; all strains were su ...19892552904
comparative in vitro and in vivo activities of piperacillin combined with the beta-lactamase inhibitors tazobactam, clavulanic acid, and sulbactam.tazobactam (ytr-830h), a novel beta-lactamase inhibitor, was compared with clavulanic acid and sulbactam for enhancement of the activity of piperacillin against beta-lactamase-producing, piperacillin-resistant clinical isolates. piperacillin mics were determined in media containing a fixed concentration of 2 or 4 micrograms of the inhibitors per ml. the higher concentration was generally more effective. tazobactam was superior to sulbactam in enhancing the spectrum and potency of piperacillin. a ...19892558615
studies to optimize the in vitro testing of piperacillin combined with tazobactam (ytr 830).the combination of piperacillin and the beta-lactamase inhibitor tazobactam (formerly ytr 830) was studied to determine optimal disk concentrations and dilution testing conditions. in addition, the potency of the combination was compared to that of piperacillin alone. the spectrum of piperacillin was greatly expanded by the addition to tazobactam principally against beta-lactamase producing strains of haemophilus influenzae, escherichia coli, morganella morganii, proteus vulgaris, providencia st ...19892560422
type 3 fimbriae among enterobacteria and the ability of spermidine to inhibit mr/k hemagglutination.the distribution of the gene cluster encoding type 3 fimbriae among various isolates of the family enterobacteriaceae was investigated by using 112 clinical and nonclinical isolates. closely related dna sequences were detected in all klebsiella strains, in most enterobacter isolates, in a smaller number of escherichia coli and salmonella spp., and in a single isolate each of yersinia enterocolitica and serratia liquefaciens but not in isolates of morganella or providencia species or serratia mar ...19892562835
ciprofloxacin in patients with bacteremic infections. the spanish group for the study of ciprofloxacin.the efficacy and safety of ciprofloxacin in the treatment of 68 episodes of bacteremia were studied. patients were treated intravenously (30 cases), orally (13 cases), or with sequential intravenous/oral therapy (25 cases). intravenous doses ranged from 200 to 400 mg per day and oral doses ranged from 1,000 to 1,500 mg per day. according to the criteria of mccabe and jackson, 39 cases had nonfatal and 29 had ultimately fatal underlying diseases. the clinical condition of patients at the start of ...19892589366
comparative in vitro activity and beta-lactamase stability of fk482, a new oral cephalosporin.fk482 is an oral aminothiazolyl hydroxyimino cephalosporin with a c-3 vinyl group. its activity was compared with those of cephalexin, cefuroxime, cefixime, and amoxicillin-clavulanate. fk482 inhibited 90% of staphylococcus aureus isolates at 1 micrograms/ml and 90% of streptococcus pyogenes, streptococcus agalactiae, and streptococcus pneumoniae isolates at less than or equal to 0.012 micrograms/ml, superior to cephalexin and cefuroxime and similar to cefixime. it did not inhibit oxacillin-resi ...19892589845
clavulanate and beta-lactamase induction.concern has been expressed that clavulanate can antagonize ticarcillin against enterobacteria and pseudomonads that have inducible expression of chromosomal 'class i' beta-lactamases. it is suggested that clavulanate-induced enzyme inactivates ticarcillin, which itself is a feeble inducer. we confirmed that this mechanism applied, showing that antagonism was abolished in beta-lactamase-basal mutants of inducible strains. antagonism has been reported in double disc tests with strains of pseudomon ...19892606817
[determination of the mic of cefotetan against freshly isolated gram-negative bacilli].antimicrobial activities (mics) of cefotetan (ctt) against 575 strains of 16 spp. of gram-negative bacilli isolated in 1988 were determined to investigate distribution of mics in comparison with those of cefmetazole (cmz), cefoxitin (cfx), latamoxef (lmox) and cefazolin (cez). the change in frequencies of incidence of cephem-resistant strains in the latter half of the 1980 was also investigated. distribution of mic of ctt varied with test strains. no or very few mics were at or higher than 12.5 ...19892621779
antimicrobial activity of dactimicin in vitro compared with that of dibekacin, netilmicin, sisomicin and micronomicin.antimicrobial activity of dactimicin, a pseudo-disaccharide aminoglycoside antibiotic, was compared with those of dibekacin, netilmicin, sisomicin and micronomicin using clinical isolates of four gram-positive and sixteen gram-negative bacteria. dactimicin was more active than the reference amino-glycosides against serratia marcescens, especially gentamicin-resistant serratia sp., proteus vulgaris, p. rettgeri and klebsiella oxytoca, but less active against pseudomonas aeruginosa and p. mirabili ...19892632214
urinary tract infections in children.from january 1981 to december 1987, 346 children with urinary tract infections, proved by urine culture, were admitted to the department of pediatrics, mackay memorial hospital. the ratio of male to female was 3.0 in children below 2 years, and 0.8 in children above 2 years, of age. the urine specimens were collected from suprapubic punctures in 281 cases (81.2%). fever was the most common clinical manifestation. in children below two years old, other common symptoms and signs were body weight l ...19892637602
[bacteriologic study of abscesses caused by bites of snakes of the genus bothrops].the bacterial flora of 99 cases of abscesses following bothrops snakebite were analysed. they corresponded to 61.1% of all snakebite abscesses observed in 1030 patients attending the hospital de doenças tropicais de goiánia in goiás, brazil, from january 1984 to april 1988. an exsudate sample of each abscess was examined by gram stain, culture and susceptibility tests. the gram negative bacillis, morganella morganii, escherichia coli and providencia sp were the most frequent bacterias isolated. ...19892640511
isolation and analysis of the c-terminal signal directing export of escherichia coli hemolysin protein across both bacterial membranes.we have studied the c-terminal signal which directs the complete export of the 1024-amino-acid hemolysin protein (hlya) of escherichia coli across both bacterial membranes into the surrounding medium. isolation and sequencing of homologous hlya genes from the related bacteria proteus vulgaris and morganella morganii revealed high primary sequence divergence in the three hlya c-termini and highlighted within the extreme terminal 53 amino acids the conservation of three contiguous sequences, a pot ...19892656259
discovery of new morganocin types of morganella morganii in strains of diverse serotype and the apparent independence of bacteriocin type from serotype of strains.a collection of 45 serologically distinct strains of morganella morganii from several european countries was typed by morganocin production (p) and sensitivity (s). this permitted their differentiation into 33 morganocin p/s types; 15 new types of morganocin and one new morganocin sensitivity type were found and are defined. morganocin production and sensitivity characteristics appeared to be unrelated to the o and h antigens of the strain. the finest strain recognition in m. morganii might be a ...19892659799
comparison of the in vitro and in vivo antibacterial activities of cefepime (bmy-28142) with ceftazidime, cefuzonam, cefotaxime and cefmenoxime.cefepime (bmy-28142), a new semisynthetic cephalosporin, was evaluated for in vitro and in vivo antibacterial activities in comparison with ceftazidime, cefuzonam, cefotaxime and cefmenoxime. cefepime showed a well-balanced, broad spectrum of activity against a number of clinical isolates collected in japan. the activity of cefepime against gram-positive bacteria was several times greater than that of ceftazidime, nearly comparable to cefotaxime and cefmenoxime, and slightly weaker than cefuzona ...19892663406
[susceptibilities of clinical isolates to antibacterial agents. a study mainly focused on ofloxacin (the second report). reported by the research group for testing ofloxacin susceptibility on clinical isolates].susceptibilities of various clinical isolates to ofloxacin (oflx) and other antibacterial drugs were examined at 128 hospital laboratories in 36 prefectures throughout japan between april, 1986 and march, 1987. the results were totalized with an emphasis mainly on oflx and were compared with data obtained in the previous year. in this study, identification and susceptibility tests of the isolates were carried out at each hospital laboratory and the tests were performed according to the 1-dilutio ...19892664255
[evaluation of a new semi-automatic method of identifying enterobacteriaceae, m.i.s.-enterobacteriaceae].m.i.s.-enterobacteriaceae is a new kit for identifying enterobacteriaceae using a microplate consisting of 21 biochemical characters with automated reading and interpretation. the validity of this method was studied by the identification of 350 strains of enterobacteria belonging to 44 species and comparison with the classical method of identification in test-tubes. results showed a diagnosis accuracy of 96 p. cent at the species level and 97.7 p. cent at the genus level. diagnosis accuracy reac ...19892665580
[properties of bacteriocins of morganella morganii].some properties of morganella morganii bacteriocins were determined. for this purpose two strains (115 and 137) which after mitomycin c induction produced bacteriocins in high titer were chosen. the influence of several physical and chemical factors such as: heating and storage at various temperatures, a freezing and thawing, an influence of buffered fluid of different ph, and digestion by trypsin, papain and lysozyme were investigated. range of bacteriocin activity against various microorganism ...19892668659
proteeae species bacteriuria accompanying proteeae species groin skin carriage in geriatric outpatients.there have been numerous reports of proteeae species urinary tract infections among elderly individuals. to explore a possible urinary carrier source of proteeae species in this population, the frequency of aerobic gram-negative bacillus (agnb) bacteriuria at the greater than or equal to 10(2)/ml level was determined in 67 ambulatory elderly outpatients classified as to proteeae group (morganella, proteus, providencia) groin carriage by a set of two skin cultures obtained at least 1 week apart. ...19892674195
in-vitro activity of fce 22101 and other beta-lactam antibiotics against enterobacteriaceae resistant to third generation cephalosporins.the in-vitro activity of fce 22101 was compared with those of imipenem, aztreonam, cefotaxime, ceftriaxone and latamoxef against 225 enterobacteriaceae (209 clinical isolates and 16 derivatives of escherichia coli k12) chosen for their resistance (mic greater than or equal to 8 mg/l) to third-generation cephalosporins. the beta-lactamases produced by the strains of enterobacter cloacae, klebsiella pneumoniae and esch. coli were identified. the mean mics of fce 22101 were 2-8 mg/l for ent. cloaca ...19892676939
in-vitro activity of meropenem against clinical isolates in a multicentre study in italy.a multicentre in-vitro study was undertaken to evaluate the susceptibility of bacterial pathogens isolated in different italian hospitals to meropenem. a total of 1399 aerobic and 452 anaerobic strains was analysed. comparative agents were imipenem, cefotaxime, ceftazidime, ceftriaxone, piperacillin, ciprofloxacin, gentamicin, amikacin, plus vancomycin when appropriate. the mic ranges (mg/l) of meropenem were: 0.015-2 for klebsiella spp., proteus spp., morganella morganii and providencia spp.; l ...19892681128
pyridoxal 5'-phosphate dependent histidine decarboxylase: overproduction, purification, biosynthesis of soluble site-directed mutant proteins, and replacement of conserved residues.the hdc gene coding for the pyridoxal 5'-phosphate dependent histidine decarboxylase from morganella morganii has been expressed in escherichia coli under control of the lac promoter. the enzyme accumulates to 7-8% of total cell protein and is purified to homogeneity by passage through three columns. fourteen site-directed mutant enzymes were constructed to explore the roles of residues of interest, especially those in the sequence ser229-x230-his231-n epsilon-(phosphopyridoxylidene)lys232, sinc ...19892684275
anti-k1 of the iga class associated with morganella morganii infection.an anti-k1 alloantibody developed in a patient infected with morganella morganii. the serologic behavior and response to dithiothreitol initially suggested that the alloantibody was an igm. however, flow cytometry and the separation of immunoglobulin classes by serum chromatography revealed that the anti-k1 was constituted solely of iga. these data suggest that bacteria-induced red cell antibodies might be of the iga class.19892749877
in vitro activity and beta-lactamase stability of a new carbapenem, sm-7338.sm-7338, a new carbapenem, inhibited most members of the family enterobacteriaceae at mics of 0.015 to 0.25 microgram/ml, including klebsiella oxytoca, citrobacter freundii, enterobacter cloacae, and proteus vulgaris isolates resistant to cefotaxime, ceftazidime, piperacillin, and gentamicin. it was two- to eightfold more active than imipenem, but it inhibited pseudomonas aeruginosa at 1 to 8 micrograms/ml, which was comparable to the activity of imipenem. haemophilus, neisseria, and branhamella ...19892789493
[the ratios and kinds of clinical bacteria isolated in taiwan's large-size hospitals].the prevalence of clinical bacteria, as isolated from linko chang-gung memorial hospital (2,300 beds) in the period january 1985 to december 1986 and from taipei veterans general hospital (2,300 beds) during the period january 1986 to december 1986, was analyzed with the following findings: (i) the isolation ratio of anaerobic and aerobic or facultative bactria during the period of investigation were 7.8% (5,513/70,799) and 92.2% (65,286/70,799), respectively. (ii) of the total aerobic or facult ...19892791722
interactions of meropenem with class i chromosomal beta-lactamases.most newer penicillins and cephalosporins are labile to the class i beta-lactamases that are inducible in pseudomonas aeruginosa. enterobacter spp., citrobacter spp., serratia spp. and indole-positive proteeae, but fail to induce enzyme synthesis below the mic. they remain active against the inducible strains but not against mutants (termed 'stably depressed') that manufacture beta-lactamase copiously without induction. such mutants are segregated at high frequency and may be selected during the ...19892808208
antibacterial activity of tigemonam dicholate (sq 30836) and interaction with beta-lactamases of gram-negative bacteria.sq 30836 is an orally absorbed salt of tigemonam, a new monobactam similar to aztreonam in structure and microbiologic properties. when assayed against 400 clinical isolates, tigemonam's activity was similar to that of aztreonam and carumonam. it was highly effective against enterobacteriaceae but showed poor activity against gram-positive organisms. it inhibited 90% of escherichia coli, klebsiella, shigella, yersinia, proteus, providencia, and morganella strains at 0.5 micrograms/ml or less, an ...19892809698
in vitro activity of tigemonam against urinary tract pathogens.tigemonam's in vitro activity was compared with that of aztreonam, cefotaxime, gentamicin, and norfloxacin. thirty-two strains of pseudomonas and 960 strains of enterobacteriaceae were studied using the agar dilution method (including escherichia coli, klebsiella pneumoniae, klebsiella oxytoca, enterobacter sp., serratia marcescens, proteus mirabilis, proteus vulgaris, morganella morganii, and salmonella enterica). tigemonam displayed good activity against enterobacteriaceae. minimum inhibitory ...19892809699
in vitro studies of tigemonam: a comparison of the minimum inhibitory and minimum bactericidal concentrations (mic vs mbc).the in vitro activity of tigemonam, a new oral monobactam, was studied with special attention to minimum inhibitory concentrations (mics) and minimum bactericidal concentrations (mbcs). against 250 clinical isolates, it inhibited 100% of escherichia sp., klebsiella sp., serratia sp., citrobacter sp., providencia sp., proteus sp., morganella sp., aeromonas sp., yersinia sp., shigella sp., and haemophilus sp. at 0.5 mg/l or less. with 1 mg/l, 75% of enterobacter sp. were inhibited; however, three ...19892809701
[pharmacokinetic and clinical studies of cefteram pivoxil granule in the pediatric field].cefteram pivoxil (cftm-pi), the pivaloyloxymethyl ester of cefteram (cftm) in which aminothiazol was also introduced into the 7 position of cephem nucleus, is a new oral cephem antibiotic. cftm-pi was absorbed through the intestines and hydrolyzed to cftm by esterases in the intestinal wall and existed in the body fluids as cftm. a tablet form of this drug has been released in japan and now a granular form for pediatric patients has been developed. we have determined mics of 5 drugs (cftm, cepha ...19892810762
in vitro evaluation of brl 42715, a novel beta-lactamase inhibitor.the penem brl 42715, c6-(n1-methyl-1,2,3-triazolylmethylene)penem, is a potent inhibitor of a broad range of bacterial beta-lactamases, including the plasmid-mediated tem, shv, oxa, and staphylococcal enzymes, as well as the chromosomally mediated enzymes of bacteroides, enterobacter, citrobacter, serratia, morganella, escherichia, klebsiella, and proteus species. the concentration of brl 42715 needed to reduce the initial rate of hydrolysis of most beta-lactamase enzymes by 50% was less than 0. ...19892817854
[the hemolytic properties of strains of morganella morganii]. 19882967119
further differentiation of enterobacteriaceae by means of siderophore-pattern analysis.by means of a combination of 5 siderophore bioassays using several indicator strains, genera, species and subspecies of enterobacteriaceae can be further differentiated. enterobactin, aerobactin and other siderophores produced can be detected. each strain shows specific pattern which we called siderophore-pattern. it is easy to separate morganella, proteus, providencia, yersinia strains from the genera salmonella, shigella, escherichia coli, enterobacter, citrobacter, klebsiella, serratia. enter ...19882970195
pyridoxal 5'-phosphate-dependent histidine decarboxylase. nucleotide sequence of the hdc gene and the corresponding amino acid sequence.the nucleotide sequence of a 1.3-kilobase naei fragment from morganella morganii am-15 that contains the gene for histidine decarboxylase has been determined. the gene was initially identified among total chromosomal digests using a mixed sequence oligonucleotide probe corresponding to amino acids 11-16 of histidine decarboxylase and then cloned on a 5.5-kilobase psti fragment. the structural gene contains 1131 nucleotides and encodes 377 amino acids with the sequence: (sequence: in text). the i ...19863015950
induction/inhibition of chromosomal beta-lactamases by beta-lactamase inhibitors.many species of gram-negative bacteria produce chromosomal beta-lactamases that can be induced to high-level expression by exposure to beta-lactam antibiotics. fifty-four strains of escherichia coli, enterobacter, proteus, citrobacter, and morganella were examined for beta-lactamase inducibility by clavulanic acid, sulbactam, ytr 830, ampicillin, and cefoxitin. cefoxitin proved to be the most potent inducer, affecting most of the strains of enterobacter and morganella. clavulanic acid induced 30 ...19863026004
identification of porins in outer membrane of proteus, morganella, and providencia spp. and their role in outer membrane permeation of beta-lactams.proteus mirabilis, proteus vulgaris, morganella morganii, providencia rettgeri, and providencia alcalifaciens, which were once classified into the same genus, proteus, were studied. cefoxitin-resistant mutants from these species were isolated, and it was confirmed that the resistance was attributed to the lack of an outer membrane protein, resulting in a significant decrease in the penetration of hydrophilic cephalosporins through the outer membrane. comparison of the mutant strains with their p ...19873034144
immunization with rough mutants of salmonella minnesota: protective activity of igm and igg antibody to the r595 (re chemotype) mutant.we evaluated the immunoglobulin class responsible for the protective activity in serum obtained from humans and rabbits after immunization with the r595 (re chemotype) mutant of salmonella minnesota. whole serum obtained before immunization and the igg and igm fractions failed to protect mice against lethal challenge with viable klebsiella pneumoniae or morganella morganii or with salmonella typhi lipopolysaccharide (lps). the protective activity of postimmunization serum resided solely in igm a ...19883042871
comparison of the haemolysin secretion protein hlyb from proteus vulgaris and escherichia coli; site-directed mutagenesis causing impairment of export function.the hlyb secretion genes of proteus vulgaris and escherichia coli showed 81% nucleotide homology and similar e. coli-atypical codon usage. the deduced protein sequences differed in 54 of 707 residues and shared a previously unreported sequence which corresponds to the atp-binding motif characteristic of protein kinases. the motif was also conserved in the hlyb of morganella morganii. of 4 oligonucleotide-directed substitutions introduced into the putative e. coli hlyb motif, 2 non-conservative c ...19883054490
chromosomal beta-lactamase expression and resistance to beta-lactam antibiotics in proteus vulgaris and morganella morganii.indole-positive members of the proteeae usually have inducible expression of chromosomal beta-lactamases. mutants with stably derepressed beta-lactamase expression occur in inducible populations at frequencies in the range of 10(-6) to 10(-8). the contribution of these beta-lactamases to drug resistance was examined in morganella morganii and proteus vulgaris. the m. morganii enzyme was a high-molecular-weight (49,000) class i cephalosporinase with low vmax rates for ampicillin, carbenicillin, a ...19883058021
[lysogeny in strains of proteus mirabilis and morganella morganii]. 19883060268
in vitro evaluation of a-56619 (difloxacin) and a-56620: new aryl-fluoroquinolones.the in vitro antibacterial potencies of a-56619 and a-56620, two new aryl-fluoroquinolones, were compared with the potency of norfloxacin against a broad spectrum of organisms. cefotaxime, aztreonam, piperacillin, imipenem, penicillin, and gentamicin were also tested for reference purposes. the mics required to inhibit at least 90% of the strains tested ranged from 0.25 to 4 micrograms/ml for a-56619 and from 0.06 to 0.5 microgram/ml for a-56620 for members of the enterobacteriaceae. a-56619 was ...19863087274
in vitro activity of aztreonam against gram negative bacteria from clinical specimens and its comparison with other commonly used antibiotics.a total of 755 gram negative bacteria isolated from clinical specimens were tested against aztreonam by the disc agar diffusion test. the strains of bacteria used in this study consisted of escherichia coli (314), enterobacter aerogenes (30), e. agglomerans (7), e. cloacae, (39), citrobacter diversus (9), c. freundii (13), hafnia alvei (3), acinetobacter calcoaceticus (10), klebsiella oxytoca (6), k. ozaenae (5), k. pneumoniae (107), morganella morganii (3), moraxella sp. (10), pasteurella multo ...19863088346
do clinical microbiology laboratories report complete bacteriology in urine from patients with long-term urinary catheters?bacteriuria associated with long-term urinary catheters (those in place for greater than or equal to 30 days) appears to be the most common nosocomial infection in u.s. medical care facilities. this bacteriuria is polymicrobial and dynamic and accompanied by fevers, catheter obstructions, bacteremias, and deaths. we compared the reporting by our research laboratory of bacteria present in urine from long-term-catheterized nursing home patients with that by two commercial laboratories. the commerc ...19863093528
induction of the beta-lactamases of a strain of pseudomonas aeruginosa, morganella morganii and enterobacter cloacae. 19873106306
purification and properties of pyridoxal-5'-phosphate-dependent histidine decarboxylases from klebsiella planticola and enterobacter aerogenes.histidine decarboxylases from klebsiella planticola and enterobacter aerogenes were purified to homogeneity and compared with the histidine decarboxylase from morganella morganii. all three enzymes required pyridoxal 5'-phosphate as a coenzyme, showed optimal activity at ph 6.5, decarboxylated only histidine among the amino acids derived from protein, and were tetramers or dimers of identical subunits. amino-terminal sequences of the three enzymes showed up to 81% homology through residue 33, bu ...19873114230
incidence of inducible beta-lactamases in gram-negative septicemia isolates from twenty-nine european laboratories. european study group on antibiotic resistance.in 1984 the european study group on antibiotic resistance (esgar), which is made up of 29 laboratories in 12 european countries, consecutively collected gram-negative bacilli and staphylococci isolates from blood and using the microdilution method performed susceptibility testing with 11 beta-lactam antibiotics. a total of 2,578 isolates were collected; 68% were gram-negatives and 32% staphylococci. pseudomonas spp. accounted for 12% of the strains, enterobacter spp. 7%, serratia spp. 3%, indole ...19873117535
in vitro activity of desacetylcefotaxime and the interaction with its parent compound, cefotaxime.antibacterial activities of cefotaxime and its major metabolite, desacetylcefotaxime, against 178 strains (of 10 species) were assessed in terms of minimum inhibitory concentrations (mic50 and mic80), and were compared with those of cefoperazone and ceftazidime. the activity of desacetylcefotaxime was several times less than that of cefotaxime against almost all of the species tested. against staphylococcus aureus, morganella morganii, enterobacter cloacae and pseudomonas aeruginosa, the mic80 v ...19883135170
mechanism of inhibition of chromosomal beta-lactamases by third-generation cephalosporins.the kinetic interactions of the beta-lactamase from enterobacter cloacae 908 r with ceftriaxone, cefotaxime, and ceftazidime have been examined in detail. with all of these cephalosporins, there is an initial rapid reaction involving opening of the beta-lactam that then decreases to a slower steady-state rate (kss) of beta-lactam hydrolysis (at 37 degrees c: ceftriaxone, kss = 0.044 s-1; cefotaxime, kss = 0.033 s-1; ceftazidime, kss = 0.011 s-1). more than stoichiometric quantities of beta-lacta ...19883142012
in vitro activity of e-1040, a novel cephalosporin with potent activity against pseudomonas aeruginosa.the in vitro activity of e-1040 [(6r,7r)-3-[(4-carbamoyl-1-quinuclidinio)methyl]-7-[2-(5-amino-1,2 ,4- thiadiazol-3-yl)-(z)-2-methoxyiminoacetoamido]-8-oxo-5-thia- 1- azabicyclo(4,2,0)oct-2-ene-2-carboxylate], a novel cephalosporin, was compared with that of ceftazidime, cefpirome, cefepime, imipenem, and gentamicin. e-1040 inhibited 50% of members of the family enterobacteriaceae, pseudomonas aeruginosa, and haemophilus and neisseria species at less than or equal to 0.25 microgram/ml, and the m ...19883150915
in vitro antibacterial activity of norfloxacin and other agents against ocular pathogens.302 clinical isolates representing 16 bacterial species most often implicated in ocular infections were tested in vitro against norfloxacin and a panel of antibacterial agents. on the basis of the 90% minimal inhibitory concentration (mic90) data, norfloxacin was 4-32 times more active than the next best antimicrobial tested against citrobacter freundii, escherichia coli, morganella morganii, proteus mirabilis, proteus vulgaris, haemophilus influenzae, neisseria gonorrhoeae and staphylococcus ep ...19853157551
[susceptibilities of clinical isolates to antibacterial agents. focusing mainly on ofloxacin (first report). reported by the research group for testing ofloxacin susceptibility of clinical isolates].susceptibility tests were carried out on a variety of clinically isolated pathogens using the susceptibility disc method at 197 hospitals in japan between may, 1985 through march, 1986. these tests were organized by the research group for testing ofloxacin susceptibility on clinical isolates, and the results were statistically analyzed. this paper describes a comparison of susceptibilities of clinical isolates including staphylococcus aureus, staphylococcus epidermidis, enterococcus faecalis, st ...19883163383
in vitro activity of lomefloxacin (sc-47111; ny-198), a difluoroquinolone 3-carboxylic acid, compared with those of other quinolones.lomefloxacin (sc-47111; ny-198) is a new difluoroquinolone agent. it inhibited 90% of escherichia coli, klebsiella spp., enterobacter spp., citrobacter spp., proteus mirabilis, morganella morganii, proteus vulgaris, serratia marcescens, salmonella spp., shigella spp., aeromonas spp., yersinia spp., haemophilus influenzae, and neisseria gonorrhoeae at less than or equal to 2 micrograms/ml. lomefloxacin inhibited 90% of pseudomonas aeruginosa at 4 micrograms/ml. lomefloxacin was equal in activity ...19883164987
properties and participation of "free" endotoxin in the toxic activity of morganella morganii."free" and "bound" morganella morganii endotoxin was characterized by chemical (determination of proteins, saccharides and 3-deoxy-2-octulosonic acid) and immunochemical (double-diffusion test, immunoelectrophoresis, tandem crossed immunoelectrophoresis) methods. chemical analysis showed that "free" endotoxin contains more protein and phosphorus and less saccharides than bound endotoxin. immunochemical tests revealed differences in the structure of polysaccharide portions of both endotoxins, and ...19883181832
isotope effect studies of the pyridoxal 5'-phosphate dependent histidine decarboxylase from morganella morganii.the pyridoxal 5'-phosphate dependent histidine decarboxylase from morganella morganii shows a nitrogen isotope effect k14/k15 = 0.9770 +/- 0.0021, a carbon isotope effect k12/k13 = 1.0308 +/- 0.0006, and a carbon isotope effect for l-[alpha-2h]histidine of 1.0333 +/- 0.0001 at ph 6.3, 37 degrees c. these results indicate that the overall decarboxylation rate is limited jointly by the rate of schiff base interchange and by the rate of decarboxylation. although the observed isotope effects are qui ...19883191100
association of reactive arthropathy and morganella morganii cross reacting with yersinia enterocolitica.two patients exhibited reactive arthropathy in association with chronic diarrhoea and abdominal pain. rising titres of agglutinating antibody to yersinia enterocolitica o3 were observed in association with arthropathy. morganella morganii was isolated from faeces of one patient in heavy growth. in both patients, absorption of the sera with morganella antigen abolished yersinia reactivity. morganella titres were more than 8 times the yersinia titres and were unaffected by absorption with yersinia ...19883194711
[evaluation on the capability of indole pyruvic acid production by members of proteeae on different brands of sulfide-indole-motility].members of proteeae were vertically inoculated into different brands of sulfide-indole-motility (sim) medium for evaluating the capability of ipa production. a total of 328 clinical strains of tribe proteeae was used as tested organisms, including 186 proteus mirabilis strains, 62 morganella morganii strains, 31 proteus vulgaris strains, 27 providencia rettgeri strains, 14 providencia stuartii and 8 providencia alcalifaciens strains. seven different brands of sim medium used in this study are ky ...19883197461
in vitro activities of a-56619 (difloxacin) and a-56620, two aryl fluoroquinolones.the in vitro activities of a56619 (difloxacin) and a-56620, two newer quinolones, have been compared with the activities of ciprofloxacin, ofloxacin, ceftazidime and netilmicin. a total of 782 clinical, bacterial isolates were employed. minimal inhibitory concentrations (mics) were determined under standard conditions with all isolates and, for 100 isolates against difloxacin and a-56620, with variation of agar ph and bacterial inoculum size. on a weight-for-weight basis, ciprofloxacin and a-566 ...19883208547
[antibacterial activities of monobactams against fresh clinical isolates].antibacterial activities of monobactam antibiotics (carumonam (crmn) and aztreonam (azt] against gram-negative bacilli isolated from inpatients in the latter half of 1987 were investigated using penicillin (pc: piperacillin (pipc], cephems (ceps: ceftazidime (caz), cefotaxime (ctx), latamoxef (lmox), cefsulodin (cfs], carbapenem (imipenem (ipm] and pyridonecarboxylic acids (norfloxacin (nflx) and ofloxacin (oflx] as reference antibiotics. a total of 400 strains of 13 species, i.e. escherichia co ...19883210297
[antibacterial activity of gentamicin against clinical isolates in pediatrics].antibacterial activity of gentamicin (gm), along with activities of other aminoglycosides and beta-lactams, was studied against clinical isolates collected from pediatric patients during a period of may 1986-april 1987. 1. gm-resistance was noted in 22% of staphylococcus aureus, 6% of proteus vulgaris, 8% of morganella morganii, 40% of providencia spp., 6% of enterobacter spp., 14% of serratia marcescens, and 14% of pseudomonas aeruginosa isolates. no gm-resistance was observed with isolates of ...19883216475
[bacteriocinogenic properties of morganella morganii]. 19883216764
[the in vitro activity of ofloxacin, pefloxacin and ciprofloxacin against various gram negative bacteria isolated from urinary tract infections].in this study the in vitro activity of ofloxacin, pefloxacin and ciprofloxacin against various gram negative bacteria isolated from urinary tract infections was examined. of 80 isolates (24 e. coli, 10 enterobacter, 10 klebsiella, 23 proteus, 10 pseudomonas, 2 morganella and 1 serratia) 49 were from inpatients, and 31 were from outpatients. ciprofloxacin was the most potent compound and no resistant strain was found against ciprofloxacin, while 1 enterobacter strain and 1 pseudomonas strain were ...19883252111
in vitro activity of an oral iminomethoxy aminothiazolyl cephalosporin, r-3746.the in vitro activity of r-3746, an iminomethoxy aminothiazolyl cephalosporin with a ch2och3 moiety at position 3, was compared with those of other antibiotics. r-3746 inhibited the majority of hemolytic streptococci (groups a, b, c, f, and g) and streptococcus pneumoniae at less than 0.06 micrograms/ml, which was comparable to the activity of amoxicillin, 2- to 8-fold more active than cefixime, and 16- to 64-fold more active than cefaclor and cephalexin. ninety percent of beta-lactamase-produci ...19883260766
activity of temocillin and other penicillins against beta-lactamase-inducible and -stably derepressed enterobacteria.mics of temocillin, carbenicillin, ticarcillin, mezlocillin, piperacillin and ampicillin were determined for mutant series of enterobacter cloacae, citrobacter freundii, proteus vulgaris, morganella morganii and serratia marcescens with inducible, stably derepressed or basal expression of chromosomal class i beta-lactamases. ampicillin was inactive (mic greater than 256 mg/l) both against beta-lactamase-inducible organisms (except c. freundii) and their stably derepressed mutants, whereas basal ...19883263354
production and properties of haemolysins from clinical isolates of the proteeae.a collection of 198 clinical isolates of strains belonging to the tribe proteeae was examined for haemolytic activity on blood agar and in brain heart infusion broth. the strains were of diverse bacteriocin and o-antigenic types and from a wide variety of sources. they included representatives of all species of morganella, proteus and providencia. approximately half of the m. morgani strains were haemolytic on blood agar. this activity was not associated with any particular bacteriocin type. the ...19883275780
a survey of iga protease production among clinical isolates of proteeae.a collection of 100 strains of proteeae, in which all species within the tribe were represented, was examined for iga protease production. the strains were isolated from various clinical specimens from sick and healthy persons in several countries. iga protease-producing strains were not found amongst species of providencia and morganella but were common in proteus spp. all the strains of p. mirabilis and p. penneri and many of the strains of p. vulgaris examined produced an edta-sensitive prote ...19883275781
rapidec ur, a 2-h miniaturized system for pinpointing uropathogens.a miniaturized 2-h system (rapidec ur; api system, la balme-les-grottes, montalieu-vercieu, france) that uses nine enzymatic tests for the diagnosis of most uropathogens was challenged with 330 strains. with few exceptions (citrobacter, enterobacter, and providencia spp., morganella morganii, and staphylococci other than staphylococcus saprophyticus), there were distinct patterns that allowed at least a preliminary species diagnosis.19883277991
tigemonam, an oral monobactam.tigemonam is an orally administered monobactam. at less than or equal to 1 microgram/ml it inhibited the majority of strains of escherichia coli, klebsiella spp., enterobacter aerogenes, citrobacter diversus, proteus spp., providencia spp., aeromonas hydrophila, salmonella spp., shigella spp., serratia marcescens, and yersinia enterocolitica. at less than or equal to 0.25 microgram/ml it inhibited haemophilus spp., neisseria spp., and branhamella catarrhalis. it did not inhibit pseudomonas spp. ...19883279906
evaluation of the ids rapid ss/u system for rapid identification of urinary microorganisms.the accuracy of a new rapid identification system for common urinary pathogens was compared with that of conventional methods and of miniaturized 18-24-hour identification panels. the rapid system, rapid ss/u (innovative diagnostic system inc., atlanta, ga) is a non-growth-dependent micro-method that identifies selected gram-negative bacilli, gram-positive cocci, and yeasts in two hours by detection of constitutive enzymes acting on chromogenic substrates. a total of 185 representative clinical ...19883285661
bacteremia and septic arthritis in a west african dwarf crocodile.an anorectic, adult west african dwarf crocodile was examined because of bilateral hind limb paresis. clinical findings included multiple skin wounds, osteomyelitis of the distal portions of the right radius and ulna, severe anemia, and serratia marcescens bacteremia. the crocodile died after a blood transfusion. at necropsy, hemorrhage in the subarachnoid space, suppurative polyarthritis, and gastric ulceration were found. serratia marcescens and morganella morganii were isolated from multiple ...19883292493
comparative in vitro activity of amoxycillin/clavulanate (augmentin), ceftazidime and ceftriaxone against hospital strains of gram-negative and -positive bacteria.the in vitro antibacterial activities of amoxycillin/clavulanate (augmentin), ceftazidime and ceftriaxone were compared against 330 gram-negative and gram-positive strains isolated from clinical specimens received at the king abdulaziz university hospital (kauh) in saudi arabia. the antibacterial susceptibility was determinated by stokes method and by the minimal inhibitory concentration (mic) using an agar dilution method. ceftazidime and ceftriaxone were the most active antibiotics, inhibiting ...19883293818
identification of two different hemolysin determinants in uropathogenic proteus isolates.dna sequences similar to those of the escherichia coli hemolysin genes were detected among uropathogenic isolates of proteus vulgaris and morganella morganii by using the southern blotting technique and hly gene-specific dna probe. immunoblotting revealed that among the hemolytic p. vulgaris and m. morganii isolates there was expressed a polypeptide species similar in molecular size (110 kilodaltons) and antigenicity to escherichia coli hlya. a plasmid-mediated p. vulgaris hemolysin determinant ...19873305367
in vitro and in vivo antibacterial activities of cs-807, a new oral cephalosporin.cs-807 is a new oral prodrug of r-3746, a cephalosporin derivative, with potent in vitro and in vivo antibacterial activity against both gram-positive and gram-negative bacteria. the susceptibility of about 1,200 clinical isolates to r-3746 was determined by the agar dilution method. ninety percent or more of pathogens such as staphylococcus aureus, streptococci, escherichia coli, klebsiella pneumoniae, klebsiella oxytoca, indole-positive and indole-negative proteus spp., providencia rettgeri, a ...19873310868
clinical significance of beta-lactamase induction and stable derepression in gram-negative rods.most strains of enterobacteria and pseudomonas aeruginosa produce chromosomally-determined class i beta-lactamases. when synthesized copiously these enzymes cause resistance to almost all beta-lactams, except imipenem and, sometimes, carbenicillin and tenocillin. elevated beta-lactamase production arises transiently, via induction, in pseudomonas aeruginosa and enterobacter, citrobacter, morganella, indole-positive proteus and serratia spp. when these organisms are exposed to beta-lactams. perma ...19873311738
epidemiology of aerobactin production in enterobacteriaceae.clinical isolates (496) of 10 different enterobacterial genera were studied for aerobactin excretion, colicin production and antibiotic resistance. in the case of escherichia coli, the incidence of aerobactin-positive strains in 108 blood isolates (45%) was not significantly different from that corresponding to faecal sources (41%). although colicin v production was much more frequently associated with aerobactin production than other colicins, colicin v was only produced by 26% of aerobactin ex ...19863318871
urease-positive bacteriuria and obstruction of long-term urinary catheters.long-term urethral catheterization (greater than or equal to 30 days), a management technique for urinary incontinence, results in polymicrobial bacteriuria. we frequently found urease-producing bacteria: of 1,135 weekly urine specimens from 32 long-term-catheterized patients, 86% had urease-positive bacterial species at greater than or equal to 10(5) cfu/ml. the most common species were proteus mirabilis and morganella morganii, each found in over half the specimens. p. mirabilis, but not other ...19873320089
microbiological perspectives of co-trimoxazole.trimethoprim-sulfamethoxazole in vitro activity was compared with ampicillin, tetracycline, sulfonamide and trimethoprim against isolates of 24 gram-negative and 11 gram-positive species. the incidence of more than 10% of strains with minimal inhibitory concentrations above 32 mg/l was restricted to escherichia coli, shigella spp., klebsiella pneumoniae, providencia rettgeri, morganella morganii, methicillin-resistant staphylococcus aureus and staphylococcus epidermidis. occasionally, streptococ ...19873325434
[the antimicrobial activity of sisomicin against fresh clinical isolates].antimicrobial activities of sisomicin (siso) against clinical isolates obtained in the second half of 1986 were investigated together with other 4 aminoglycosides (ags) (gentamicin (gm), tobramycin (tob), dibekacin (dkb), amikacin (amk] and 2 cephems (cefotiam, cefotaxime), and were compared to the results reported in the period of late 1970's through early 1980's in japan. 1. the incidence of siso-resistant staphylococcus aureus in the present study was 18% and is comparable to that of the othe ...19873327965
a survey of clinical experience with ciprofloxacin, a new quinolone antimicrobial.ciprofloxacin is a new quinolone antimicrobial agent with activity against a broad spectrum of gram-negative and gram-positive organisms, including pseudomonas aeruginosa and methicillin-resistant strains of staphylococci. the efficacy and safety results of 80 clinical studies of the oral form of ciprofloxacin are reported. drug safety was assessed in 2236 courses in 2203 adult patients treated primarily in the united states. data from 1676 courses were suitable for analysis of drug efficacy. th ...19883360968
predictors of endocarditis in isolates from cultures of blood following dental extractions in rats with periodontal disease.rats with periodontitis and catheter-induced aortic valve vegetations underwent dental extractions. cultures of blood obtained 1 min later showed polymicrobial bacteremia in 19 of 19 rats, mostly due to viridans streptococci (18 of 19), morganella (15 of 19), group g streptococci (13 of 19), and staphylococcus aureus (10 of 19). viridans streptococci circulated in higher numbers than did group g streptococci and s. aureus (p less than .01). three days after dental extractions, 18 of 20 rats had ...19883361156
Displaying items 101 - 200 of 853