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distribution and activity of histidine decarboxylase in morganella. 195813575010
morganella morganii antigenically related to escherichia coli 0111: k58(b4). 19674860403
antigenic relationships between morganella morganii and different genera of enterobacteriaceae. 19676048150
five new serotypes of morganella morganii. 19676048149
[candida albicans (ch. robin, 1853), pseudomonas aeruginosa (schroeter, 1872), and morganella morgani (winslow et al., 1919), proofs of organic decline]. 19724628508
serological relationship between pseudomonas aeruginosa and enterobacteriaceae. ii. relationship of pseudomonas aeruginosa o antigens to escherichia, shigella, proteus, morganella, rettgerella and providencia. 19734205984
[characteristics of the klebsiella, proteus and morganella isolated from infants with acute gastrointestinal diseases]. 19744463338
[microbiological characteristics of bacteria of the genera proteus and morganella isolated from ill and healthy children]. 19751094728
[in vitro examination on antibacterial activities of broad-spectrum antibiotics against gram-negative clinical isolates (author's transl)].in vitro studies were undertaken on clinically isolated strains of various bacteria to examine the antibacterial activity of ampicillin (ab-pc), carbenicillin (cb-pc), sulbenicillin (sb-pc) cephalothin (cet), cefazolin (cez) and gentamicin (gm). fifty three % of escherichia coli strains 53.3% of citrobacter sp., 80% of proteus mirabilis, 42.9% of morganella and 80% of bacteroides sp. were susceptible (mic being not higher than 12.5 mug/ml) to ab-pc. the eight other species were not so susceptibl ...19751104913
new serotypes of morganella morganii.on the basis of 8 new o and 11 new h antigens determined in 22 strains, the morganella morganii antigenic schema was supplemented with 8 serogroups (o35-o42) and 13 serotypes. four strains belonged to o groups described earlier and 2 strains contained new o antigens in combination with known o antigens. known h antigens were present in one strain as a single factor and in one strain as combination of two factors. new h antigens were demonstrated in 5 serotypes in combination with known h antigen ...19751155231
antigenic relationship between morganella morganii and yersinia enterocolitica.two new o antigens have been described for the morganella morganii antigenic schema. o antigens of the strains representing the new serotypes (o43 :h2 and o44 : h19, 37) are related to yersinia enterocolitica o9 and o17, respectively.197659520
[bacteria of the genus morganella]. 1976782106
o antigen grouping of morganella morganii (proteus morganii) by slide agglutination.antisera were prepared against morganella morganii (proteus morganii) type strains from the scheme described by rauss et al. (acta microbiol. acad. sci. hung. 22:315--321, 1975) and raus and vörös (acta microbiol. acad. sci. hung. 6:233--248, 1959; acta microbiol. acad. sci. hung. 14:195--198, 1967). the specificities of the somatic (o) antigens were studied using the passive hemagglutination and slide agglutination techniques. previously unreported interstrain relations were observed, and o gro ...1979500798
unusual groups of morganella ("proteus") morganii isolated from clinical specimens: lysine-positive and ornithine-negative biogroups.morganella ("proteus") morganii is the only species in the recently proposed genus morganella, but we suspect there are yet undescribed species in the genus. two candidates for new species were recently investigated. nineteen strains isolated from clinical specimens resembled m. morganii but were lysine positive and nonmotile and fermented glycerol within 24 h. typical m. morganii are lysine negative and motile and ferment glycerol slowly or not at all. the three-test variance from typical m. mo ...19806775010
evaluation of the four-hour micro-id technique for direct identification of oxidase-negative, gram-negative rods from blood cultures.a 4-h micro-id technique for direct identification of oxidase-negative gram-negative rods from positive blood cultures was compared to subculture and species identification of single colonies by api 20e and micro-id, using standardized inocula. a total of 127 patients (220 positive cultures) were studied. isolates included 96 escherichia coli, 46 klebsiella pneumoniae, 7 klebsiella oxytoca, 8 enterobacter aerogenes, 17 enterobacter cloacae, 19 serratia marcescens, 2 serratia liquefaciens, 8 prot ...19806999020
hospital cluster epidemic with morganella morganii.a cluster epidemic of 13 morganella morganii infections involving 11 patients occurred over a 3-month period in 1977. this epidemic was unusual in that it involved four services and five hospital floors. the outbreak was effectively terminated when strict asceptic techniques were reinforced.19817309851
worldwide clinical experience with cefoperazone.the safety and clinical efficacy of cefoperazone 1 to 2g 12-hourly was evaluated in clinical trials conducted in the united states, europe, south and latin america, and japan. 1046 patients were treated in 4 comparative and 9 non-comparative studies. an overall satisfactory clinical response for cefoperazone therapy was achieved in 540 (88%) of the 615 evaluable patients. cefoperazone was effective in 92% of lower respiratory tract infections, 81% of urinary tract infections, 98% of gynaecologic ...19816456884
in vitro antimicrobial activity evaluation of cefodizime (hr221), a new semisynthetic cephalosporin.cefodizime (hr221) is a new alpha-methoxyimino cephalosporin developed by hoechst-roussel with a reported serum half-life of over 2 h. in vitro susceptibility studies showed that the cefodizime spectrum includes all those enterobacteriaceae, staphylococci, streptococcus spp., haemophilus spp., and neisseria spp. normally susceptible to cefotaxime (hr756) or ceftizoxime (fk749) or both. cefodizime was less active (two- to eightfold) than cefotaxime or ceftizoxime against some enteric species, but ...19816275785
in-vitro activity of ceftazidime, a beta-lactamase stable cephalosporin.the in-vitro activity and beta-lactamase stability of ceftazidime were evaluated against 700 gram-positive and gram-negative bacteria. ceftazidime was less active than penicillins or older cephalosporins against staphylococcus spp. and streptococcus spp., and it did not inhibit streptococcusfaecalis. however, ceftazidime was as active as moxalactam and cefoperazone against escherichia coli, klebsiella and proteus mirabilis with mics less than 0.2 mg/l. ceftazidime also inhibited enterobacter, ci ...198119810175
antimicrobial activity of desacetylcefotaxime alone and in combination with cefotaxime: evidence of synergy.the level of antimicrobial activity of 3-desacetylcefotaxime was found to be approximately eightfold lower than that of cefotaxime. variation in the inhibitory effects of desacetylcefotaxime was species dependent. desacetylcefotaxime was 1-2 log2 dilutions more active than cefotaxime against pseudomonas acidovorans and pseudomonas cepacia. desacetylcefotaxime and cefotaxime were bactericidal, and their minimal inhibitory concentrations were influenced only slightly by increases in the inoculum c ...19826294785
antibacterial activity of desacetylcefotaxime alone and in combination with cefotaxime.cefotaxime is metabolized to 3-desacetylcefotaxime. the antibacterial activity of desacetylcefotaxime is four- to eightfold less than that of cefotaxime. the activity of desacetylcefotaxime is species- and strain-specific. although desacetylcefotaxime is less active than cefotaxime, it is more active than cefazolin, cefamandole, or cefoxitin. desacetylcefotaxime does not inhibit many strains of morganella, most strains of pseudomonas aeruginosa, some strains of serratia marcescens, some strains ...19826294786
antibacterial activity and beta-lactamase stability of ceftazidime, an aminothiazolyl cephalosporin potentially active against pseudomonas aeruginosa.the in vitro activity and beta-lactamase stability of ceftazidime were evaluated against 700 gram-positive and gram-negative bacteria. ceftazidime was less active than penicillins or older cephalosporins against staphylococcus spp. and streptococcus spp., and it did not inhibit streptococcus faecalis, listeria, or anaerobic species. ceftazidime was as active as ceftizoxime and moxalactam and more active than cefoperazone against escherichia coli. klebsiella, and proteus mirabilis with minimal in ...19826805421
synergistic activity of mecillinam in combination with the beta-lactamase inhibitors clavulanic acid and sulbactam.the beta-lactamase inhibitors clavulanic acid and sulbactam were combined with mecillinam. beta-lactamase-containing escherichia coli resistant to mecillinam was synergistically inhibited by both clavulanic acid and sulbactam. beta-lactamase-containing enterobacter was synergistically inhibited, but strains lacking beta-lactamases were not synergistically inhibited. synergistic inhibition was noted for beta-lactamase-containing, mecillinam-resistant klebsiella, citrobacter, serratia, and salmone ...19826291454
cefotaxime: a review of in vitro antimicrobial properties and spectrum of activity.cefotaxime has remarkable potency against all enterobacteriaceae, including enterobacter species, citrobacter freundii, serratia marcescens, and morganella morganii, proteus vulgaris, and providencia species--all of which are resistant to earlier cephalosporins. cefotaxime generally inhibits greater than 90% of enteric bacilli at concentrations of less than or equal to 0.5 microgram/ml; in one study it inhibited greater than 98% of isolates at less than or equal to 8 micrograms/ml. for staphyloc ...19826294779
treatment of urinary tract infections with cefotaxime: noncomparative and prospective comparative trials.three studies evaluated the efficacy of cefotaxime for the treatment of urinary tract infections. an open, multicenter, noncomparative trial included 477 patients who received a usual dose of 2 g of intravenous or intramuscular cefotaxime daily for five to 10 days. the maximal daily dosage in severe cases was 12 g. pathogens included escherichia coli and species of citrobacter, pseudomonas, klebsiella, enterobacter, serratia, morganella, providencia, and proteus. of all the causative organisms, ...19826294793
reliability of early identifications obtained with enterobacteriaceae-plus biochemical cards in the automicrobic system.the automicrobic system (ams) is capable of identifying most enterobacteriaceae within 8 h and many glucose-nonfermenting, gram-negative bacilli after 13 h of incubation. early preliminary results can be readily obtained from the computer as the tests incubate. data with 1,023 bacterial isolates were reviewed to determine the relative accuracy of 4-, 6-, 8-, 10-, and 13-h identifications. all automicrobic system identifications with probability (p) values of less than 0.80 were considered equivo ...19826749890
comparison of three methods for identification of enterobacteriaceae.this study compares the ability of three commercial overnight methods, api 20e, minitek and enteric-tek, to accurately and completely identify 368 clinically isolated enterobacteriaceae without supplemental tests. organisms included escherichia coli (54 strains), shigella spp. (7), edwardsiella tarda (1), salmonella enteritidis (10), citrobacter spp. (30), klebsiella spp. (55), enterobacter spp. (68), hafnia alvei (2), serratia spp. (33), proteus spp. (64), morganella morganii (24), providencia ...19826756905
comparison of micro-id and api 20e in rapid identification of enterobacteriaceae.the effectiveness of micro-id and api 20e as same-day identification systems for enterobacteriaceae was evaluated in comparison with conventional identification by using 315 clinical isolates and 90 stock strains. the api 20e system was heavily inoculated according to manufacturer's recommendations for same-day identification. we found that 83 and 81% of isolates provided adequate inocula for micro-id and api 20e, respectively, and purity of the heavy inocula was not a problem with either system ...19827047556
penem derivatives: beta-lactamase stability and affinity for penicillin-binding proteins in escherichia coli.penem derivatives, a new group of beta-lactam antibiotics with potent activities against a wide range of bacteria, including pseudomonas aeruginosa, were tested for their stability against hydrolysis by beta-lactamases purified from clinical isolates of morganella morganii. proteus vulgaris, and escherichia coli and by a penicillinase from bacillus cereus. penems having 6 alpha substituents, such as hydroxyethyl, hydroxymethyl, and ethyl groups, were very stable against hydrolysis by each of the ...19827049076
comparison of two methods for same-day identification of enterobacteriaceae.two commercial methods, api 20e (as modified for same-day enterobacterial identification) and micro-id, were evaluated for ability to provide useful same-day information of 368 clinically isolated enterobacteriaceae. organisms included escherichia coli (54), shigella (7), edwardsiella tarda (1), salmonella enteritidis (10), citrobacter (30), klebsiella (55), enterobacter (68), hafnia alvei (2), serratia (33), proteus (64), morganella morganii (24), providencia (18), and yersinia enterocolitica ( ...19827051807
hand carriage of aerobic gram-negative rods by health care personnel.a quantitative culture technique (hand washed in a glove containing broth for 30 s) was used to determine the frequency of hand carriage of aerobic gram-negative rods by various groups of health care workers and 104 control subjects. overall, 31% of health care workers carried aerobic gram-negative rods on their hands compared to 59% of control subjects (p < 0.001). enterobacter agglomerans accounted for 40% of the isolates, and other enterobacter spp. 7%. other organisms included acinetobacter ...19827097001
[antibiograms in ambulatory medical practice. results with a group of gram-negative bacilli strains isolated by uroculture].during the april 1979--june 1978 period, 1161 tests were carried out on the sensitivity to antibiotics and chemotherapeutical agents of gram-negative bacillus strains isolated from 7632 urocultures. resistance was tested under qualitative control against 13 antimicrobial agents by the kirby-bauer diffusimetric method. the resistance sensitivity and the presence of intermediary strains is shown for e. coli citrobacter, enterobacter, klebsiella, proteus, morganella, providencia, and pseudomonas. a ...19827156696
in vitro activity and beta-lactamase stability of cefmenoxime.the activity of cefmenoxime, an aminothiazolyl cephalosporin, was studied against 650 bacteria. it was slightly less active than cefotaxime and more active than moxalactam against staphylococci. it had activity similar to that of cefotaxime and ceftizoxime against group a and b streptococci and streptococcus pneumoniae. it did not inhibit streptococcus faecalis or listeria spp. cefmenoxime had activity similar to that of cefotaxime, ceftizoxime, ceftazidime, and moxalactam against escherichia co ...19826100427
haemagglutinins and fimbriae of morganella, proteus and providencia.one hundred and thirteen strains of morganella, proteus and providencia, grown in different cultural conditions, were examined for their ability to produce haemagglutinins (has). three main kinds of ha (ms, mr/k and mr/p) were detected, and 89% of the 112 ha+ strains were capable of producing two or three of the different has in the same or different cultures. the properties of the three has were partly defined and the difficulties of identifying their separate ha activities when present togethe ...19826129324
in vitro activity of norfloxacin, a quinolinecarboxylic acid, compared with that of beta-lactams, aminoglycosides, and trimethoprim.norfloxacin is a quinolinecarboxylic acid compound. we examined the in vitro activity of this compound against gram-positive and -negative species, including anaerobic species. it inhibited 90% (mic90) of strains of escherichia coli at 0.05 microgram/ml, klebsiella sp. at 0.4 microgram/ml, salmonella and shigella spp. at 0.1 microgram/ml, citrobacter sp. at 0.4 microgram/ml, enterobacter cloacae at 0.2 microgram/ml, enterobacter aerogenes at 0.4 microgram/ml, and enterobacter agglomerans at 0.2 ...19826214995
comparison of the lipoprotein gene among the enterobacteriaceae. dna sequence of morganella morganii lipoprotein gene and its expression in escherichia coli.a dna sequence of 532 base pairs encompassing the entire morganella morganii lipoprotein gene (lpp) was determined. sequence comparisons of the m. morganii lpp gene with the lpp genes from escherichia coli, serratia marcescens, and erwinia amylovora reveal that the m. morganii lpp gene is more distantly related to the e. coli lpp gene than any of the other lpp genes examined. between the e. coli and m. morganii lpp genes, the following homologies were found: 44% in the promoter region (bases, -4 ...19836305973
[in vitro bacteriostatic activity of cefmenoxime (sce 1365), cefotaxime and moxalactam].the in vitro activity of cefmenoxime (sce 1365), a new cephalosporin derivate was compared with two other "third generation" cephalosporins: cefotaxime and moxalactam. cefmenoxime as cefotaxime and moxalactam were very active against 305 cephalosporinase-producing and cephalosporinase-non-producing enterobacteriaceae. cefmenoxime was the most active against serratia marcescens, citrobacter freundii, morganella morganii, salmonella, shigella and yersinia enterocolitica with a mean mic at least tw ...19836312395
[antibiotic activity and synergism of ceftazidime and netilmicin against gram-negative pathogenic bacteria].the in vitro activity of ceftazidime and netilmicin against gram-negative bacteria often causing hospital infections was evaluated and furthermore synergistic effects of these antibiotics were studied. ceftazidime was as active as netilmicin against enterobacteriaceae, e.g. enterobacter, klebsiella, morganella inhibiting 90% of these strains at concentrations from 0.5 to 4 micrograms/ml. ceftazidime was the most effective agent against pseudomonas aeruginosa, being even more active than cefsulod ...19836320836
in vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim.enoxacin is a new quinolone carboxylic acid compound. its activity against 740 bacterial isolates was determined. it inhibited 90% escherichia coli, klebsiella sp., aeromonas sp., enterobacter spp., serratia spp., proteus mirabilis, and morganella morganii at less than or equal to 0.8 micrograms/ml. the majority of pseudomonas aeruginosa was inhibited by less than or equal to 3.1 micrograms/ml. haemophilus spp. and neisseria spp. were inhibited by less than 0.1 micrograms/ml. although most staph ...19836229216
the in-vitro activity of o-demethylfortimicin.the activity of o-demethylfortimicin against ampicillin, cefazolin and carbenicillin resistant bacteria was determined. o-demethylfortimicin showed excellent in-vitro activity against escherichia coli, klebsiella pneumoniae, enterobacter cloacae, ent. agglomerans, ent. aerogenes, citrobacter freundii, proteus vulgaris, morganella, and providencia inhibiting these organisms at less than or equal to 3.1 mg/l. it was particularly effective against ent. cloacae and serratia marcescens that were resi ...19836833173
bacteriological studies of the enteric flora of patients treated with bicozamycin (cgp 3543/e) for acute nonparasitic diarrhea.during a therapeutic trial of bicozamycin (bi) for traveler's diarrhea, aerobically grown, gram-negative bacteria, predominantly escherichia coli, were decreased by 2 to 3 logs per g of stool; the number of bi-resistant gram-negative bacteria did not increase. resistant species were most often citrobacter freundii, klebsiella pneumoniae, and morganella morganii, and few bi-resistant e. coli strains were isolated. cross-resistance between bi and other antimicrobial agents was not found. resistanc ...19836859842
nonspecific induction of beta-lactamase in enterobacter cloacae.since the introduction of the new beta-lactamase-stable beta-lactam compounds, inducible beta-lactamases have become increasingly important clinically [1]. it has recently been pointed out that most beta-lactam antibiotics appear to be affected by these derepressed enzymes either by hydrolysis or by the nonhydrolytic barrier mechanism [2]. until now, it has generally been assumed that beta-lactamases are induced only by the beta-lactam compounds themselves. we investigated an e cloacae strain th ...19836605393
in vitro antibacterial activity and beta-lactamase stability of e-0702, a new cephalosporin.the in vitro activity of e-0702 was compared with the in vitro activity of cefotaxime, ceftazidime, moxalactam, and aztreonam against 600 gram-positive and gram-negative aerobic and anaerobic isolates. e-0702 had a minimal inhibitory concentration for 50% of isolates (mic50) of 25 micrograms for staphylococcus aureus, 50 micrograms for staphylococcus epidermidis, and 1.6 to 3.1 micrograms for streptococci, with streptococcus faecalis resistant. e-0702 had mic50s against escherichia coli, klebsie ...19836605718
comparative activity of cefotetan on escherichia coli k12 possessing plasmid-mediated beta-lactamases.the antibacterial activity of cefotetan, a new cephamycin, was compared with that of cephalothin, cefoxitin, cefamandole, cefoperazone and cefotaxime on 12 substrains of escherichia coli k12 bm13 harbouring single and multi-copy plasmids coding for plasmid-mediated beta-lactamases tem, shvi, oxa-i and oxa-iii. the 99% inhibitory concentrations (ic99) for the recipient strain were increased in proportion to the enzyme activity in the case of cefamandole and cefoperazone. in contrast, the activity ...19836341349
serious nosocomial infection caused by morganella morganii and proteus mirabilis in a cardiac surgery unit.in july and august 1981, five patients in the cardiac surgery unit of the bristol royal infirmary developed septicemia caused by morganella morganii, proteus mirabilis, or both of these species. three of the patients had serious wound infections, and three of the patients died. typing of the m. morganii isolates by o-serotyping and of the p. mirabilis isolates by o-serotyping, proticine production and sensitivity, and the dienes reaction confirmed cross infection by both species. although m. mor ...19836350354
in-vitro synergism between mezlocillin and isoxazolyl penicillins against beta-lactamase-producing gram-negative organisms.forty beta-lactamase producing gram-negative organisms were tested with mezlocillin plus an isoxazolyl penicillin for synergy. with standard chequerboard techniques, the combination showed enhanced activity, when compared to either drug alone, against 30 strains. eighteen of these 30 strains showed synergism at concentrations of mezlocillin and isoxazolyl penicillins which were attainable in the serum (7 strains of morganella morganii, 8 strains of eschericia coli and 3 strains of serratia marce ...19836222024
effect of 7 alpha substitution of cephems on their beta-lactamase stability and affinity for penicillin-binding proteins in morganella morganii.cephamycins, which have a methoxy group at the 7 alpha position of their cephalosporin nuclei, were highly stable against hydrolysis by a beta-lactamase purified from a clinical isolate of morganella morganii, whereas their 7 alpha-h analogs were rapidly hydrolyzed by the enzyme. the high stability of the cephamycins was not due to their low affinity for the enzyme, since the cephamycins strongly inhibited the enzyme in a competitive manner. in cases in which the 7 alpha-methoxy group was substi ...19836602587
the effect of piperacillin prophylaxis on the colonic microflora in patients undergoing colorectal surgery.piperacillin was given parenterally in doses of 4 g every 8 h for two days to 20 patients undergoing colorectal surgery. a series of serum and fecal specimens were taken to analyse piperacillin concentrations. tissue samples from the gut wall were taken during surgery. the maximum serum concentrations during surgery were reached 15 min after piperacillin administration. on day 0 the mean half-life was 1.9 h and the mean area under the serum concentration curve was 536.8 mg/l. the piperacillin co ...19836642676
beta-lactamase inhibitory activity of iodopenicillanate and bromopenicillanate.iodopenicillanate and bromopenicillanate were shown to be effective inhibitors of a variety of beta-lactamases. staphylococcus aureus isolates were synergistically inhibited by iodopenicillanate and bromopenicillanate combined with ampicillin. methicillin-resistant s. aureus was not synergistically inhibited. escherichia coli which possessed tem beta-lactamase activity had a reduction in ampicillin minimal inhibitory concentration, but an e. coli isolate which had chromosomal beta-lactamase and ...19836299186
treatment of experimental chronic osteomyelitis caused by morganella morganii with mezlocillin and cloxacillin.mezlocillin was used alone and in combination with cloxacillin in the treatment of chronic experimental osteomyelitis due to morganella morganii. this combination showed in vitro synergy as measured by the checkerboard technique. a marked inoculum affect was demonstrated in vitro with mezlocillin and the infecting strain of m. morganii. in therapeutic trials, mezlocillin administered for 28 days was totally ineffective. the combination of mezlocillin and cloxacillin (at 800 and 400 mg/kg, respec ...19846563980
evaluation of a two-hour method for screening pathogens from stool specimens.the 2-h stool-screening test (sst) (api system s.a., montalieu-vercieu, france) was used to screen 231 organisms yielding suspicious colonies on stool differential agars for potential pathogens. all 54 salmonellae yielded correct screens. of 14 shigellas, 9 keyed as possible shigella spp.-yersinia enterocolitica-rare salmonella spp. (sys), and 5 (all shigella sonnei) keyed as possible s. sonnei-y. enterocolitica-arizona spp. (sya). three arizona strains were identified as probable salmonella spp ...19846386849
simple spot test for rapid detection of urease activity.a spot test for the detection of urease activity was developed and evaluated with 761 strains of gram-negative bacteria. the test was compared with the conventional christensen urea agar slants and urease test on the vitek enterobacteriaceae card (vitek systems, inc., st. ana, mo.). of the 348 strains of the proteus-providencia-morganella group that were urease positive, 327 (94%) yielded positive results within 1 min, and all strains yielded positive results within 2 min. all these organisms al ...19846394623
rapid test for determination of urea hydrolysis.a urease test for the rapid determination of urea hydrolysis is described in which diluted urea agar concentrate was used in small amounts with dense inoculum of the test organisms. the method was evaluated and compared with christensen's urea agar slants by using 728 clinical isolates of gram-negative bacteria. of the 325 strains of urease-positive proteus-providencia-morganella, 282 (87%) gave positive results within 5 min with the rapid test. urease activity of 97% of these organisms became e ...19846395804
third-generation cephalosporins: a critical evaluation.six third-generation cephalosporins--cefotaxime, moxalactam, cefoperazone, ceftizoxime, ceftriaxone, and cefmenoxime--are reviewed; covered are chemistry and structure-activity relationships, mechanism of action, spectra of activity, pharmacokinetics, clinical utility, adverse effects, and cost effectiveness. the third-generation cephalosporins have a similar mechanism of action to that of other beta-lactam antibiotics. none of the agents is particularly active against certain gram-positive bact ...19846432420
comparative evaluation of the eiken and api 20e systems and conventional methods for identification of members of the family enterobacteriaceae.to evaluate the accuracy and utility of the eiken systek no. 1 (eiken system; eiken chemical co., ltd., tokyo, japan), we conducted a clinical comparison, with 345 enterobacteriaceae isolates, of the eiken system with api 20e (analytab products, inc., plainview, n.y.) and conventional methods. the eiken system is a 21-biochemical-test battery tray stored at 25 degrees c and inoculated in one step. it is similar to the api 20e except that the eiken system contains malonate, adonitol, and maltose; ...19846490860
comparative in-vitro activity of quinolone carboxylic acids against proteeae.the in-vitro susceptibilities of 198 isolates of precisely identified proteeae species to six quinolone antimicrobials were determined. significant differences in susceptibility patterns among various proteeae to the quinolones examined were demonstrated. although providencia stuartii was found to be the most resistant to quinolones including the very active agent ciprofloxacin, fully speciated prov. rettgeri were also markedly resistant as well. in contrast prov. alcalifaciens was extremely sen ...19846511707
morganella morganii: epidemiology of bacteremic disease.a retrospective review of microbiology records revealed 19 documented episodes of m. morganii bacteremia in 18 patients at a veterans administration hospital during a 5.5 year period. thirteen of 19 bacteremias were related to nosocomial infections; 11 of the 13 nosocomial bacteremias occurred in surgical patients. nine of the 13 patients with nosocomial bacteremia had received recent therapy with a beta-lactam antibiotic. the most common source of bacteremia was a postoperative wound infection ...19846561180
influence of spontaneous and inducible beta-lactamase production on the antimicrobial activity of recently developed beta-lactam compounds.the activity of 9 recently developed beta-lactam compounds was evaluated in 185 ampicillin-resistant isolates of enterobacteriaceae. moreover, in all strains, spontaneous and inducible beta-lactamase production was quantified and correlated with the minimal inhibitory concentration (mic) of each compound. in most species, no correlation could be observed between spontaneously produced beta-lactamase and the mics, with the only exceptions of serratia spp. and morganella morganii isolates for meth ...19846610539
in vitro antagonism between n-formimidoyl thienamycin and aztreonam, ticarcillin and ticarcillin/clavulanic acid.one-hundred eighty-seven bacterial strains were tested by the two-disk-agar diffusion method for the interaction between n-formimidoyl thienamycin and aztreonam, ticarcillin and ticarcillin-clavulanic acid. an antagonism between n-formimidoyl thienamycin and the other 3 beta-lactams was noted in half of the evaluable tests, especially against pseudomonas, escherichia coli and morganella.19846594965
in vitro activity of pefloxacin compared to that of quinolones and other antimicrobial agents.pefloxacin is a new methyl-4-piperazinyl quinolone. it had mic90 values of less than 0.01 to 0.8 micrograms/ml for the majority of escherichia coli, klebsiella, oxytoca, citrobacter, providencia, enterobacter cloacae, enterobacter aerogenes, morganella and proteus mirabilis. it inhibited ampicillin, cephalexin and nalidixic acid resistant isolates of these species. against pseudomonas the pefloxacin mic90 was 3.1 micrograms/ml. staphylococcus aureus had a mic50 of 0.4 micrograms/ml and a mic90 o ...19846241847
the in vitro antimicrobial activity of desacetylcefotaxime compared to other related beta-lactams.like all other cephalosporins that contain an acetyl side chain in the 3' position, cefotaxime (ctx) is partially desacetylated in vivo. desacetylcefotaxime (des-ctx) possesses a broad antimicrobial spectrum and high beta-lactamase stability. with the exception of pseudomonas aeruginosa, morganella morganii, bacteroides fragilis, and staphylococcus aureus, most strains of other species tested usually had mean mics of des-ctx lower than 1 microgram/ml. its activity is generally lower than that of ...19846086214
efficacy of ceftizoxime administered twice daily in hospitalized patients with respiratory tract infections.the efficacy and safety of ceftizoxime administered twice daily were evaluated in 215 hospitalized patients with documented lower respiratory tract infections. the majority of patients received 1 to 2 gm of ceftizoxime intramuscularly or intravenously every 12 hours; the mean dosage was 2 gm/day, and the mean duration of therapy was 8.9 days. clinical cure was achieved in 204 (95%) of the 215 patients with lower respiratory tract infection. one hundred and thirty-eight patients were both clinica ...19846097357
[hplc study of the inhibition of enterobacterial cephalosporinases by cefmenoxime].high performance liquid chromatography (hplc) has shown that cefmenoxime and cefotaxime are stable to the cephalosporinase of enterobacter cloacae p99 , morganella morganii gn 1510 and serratia liquefaciens 132. they are significantly resistant to hydrolysis by 100 cephalosporinase units (cephalosporinase production of 10(12) bacterial). cefmenoxime and cefotaxime are also inhibitors of cephalosporinase at the concentration of 5.10-10 micrograms per 10-10 unit of enzyme.19846330649
susceptibility of gram-negative bacteria to polymyxin b nonapeptide.subinhibitory concentrations of polymyxin b nonapeptide sensitized all 21 polymyxin-susceptible gram-negative bacterial strains studied to hydrophobic antibiotics such as fusidic acid, novobiocin, and erythromycin. the susceptibility increases were usually 30- to 300-fold. the strains included representatives of escherichia coli with different o- and k-antigens, klebsiella pneumoniae, klebsiella oxytoca, enterobacter cloacae, enterobacter agglomerans, salmonella typhimurium, acinetobacter calcoa ...19846331296
hemorrhagic bullae associated with morganella morganii septicemia.to our knowledge this is the first case of hemorrhagic bullae caused by morganella morganii septicemia. the presence of organisms in the bullae, demonstrated by gram strain and culture, and the acral location of the bullae suggest that the skin lesions were due directly to blood-borne infection. multiple factors predisposed this patient to gram-negative bacteremia, including lymphoma, chemotherapy, neutropenia, systemic steroids, multiple hospitalizations, and treatment with broad-spectrum antib ...19853886721
evolution of the lipoprotein gene in the enterobacteriaceae. cloning and dna sequence of the lpp gene from proteus mirabilis.we cloned the lipoprotein gene from proteus mirabilis and determined its dna sequence. comparison with the lpp genes from escherichia coli, serratia marcescens, erwinia amylovora and morganella morganii revealed several unique features of the evolution of the lpp gene in the enterobacteriaceae and enabled us to establish phylogenetic relationships between these bacteria.19853903165
ceftriaxone: a beta-lactamase-stable, broad-spectrum cephalosporin with an extended half-life.ceftriaxone is an aminothiazolyl-oxyimino cephalosporin. it possesses the typical in vitro activity of a third-generation cephalosporin with excellent activity against many gram-negative aerobic bacilli: escherichia coli; species of proteus, klebsiella, morganella, providencia and citrobacter; and enterobacter agglomerans. ceftriaxone also has outstanding bactericidal action against pneumococci, group b streptococci, meningococci, gonococci and hemophilus influenzae. in healthy volunteers, it ha ...19853906584
aztreonam therapy for complicated urinary tract infections caused by multidrug-resistant bacteria.aztreonam was administered to 145 consecutive patients with complicated urinary tract infections caused by multidrug-resistant, aztreonam-sensitive bacteria. multidrug resistance was defined by disk diffusion testing as resistance to aminopenicillins and to first- and second-generation cephalosporins, with or without resistance to aminoglycosides. the first 40 assessable patients received 1 g of aztreonam intravenously three times daily for a median period of eight days; the remaining 95 assessa ...19853909335
the in vitro activity and beta-lactamase stability of cefpirome (hr 810), a pyridine cephalosporin agent active against staphylococci, enterobacteriaceae and pseudomonas aeruginosa.the in vitro activity of cefpirome, a new cyclopyridinium cephalosporin, was evaluated against 947 aerobic and anaerobic bacteria. cefpirome inhibited 90% of escherichia coli, klebsiella spp., citrobacter diversus, morganella morganii, proteus vulgaris, proteus mirabilis, aeromonas spp., salmonella spp., shigella spp. and haemophilus and neisseria species at less than or equal to 0.4 mg/l. it had activity comparable to that of cefotaxime, ceftizoxime, ceftazidime, aztreonam, and moxalactam again ...19853928497
antibiotic-resistant flora in nursing home patients admitted to the hospital.to study carriage of multiply resistant gram-negative bacilli, 50 patients admitted to the hospital from nursing homes (nhs) and 50 control admissions not from nhs were matched for age and recent antibiotic use. their antibiotic resistance patterns were similar: 20 nh patients and 14 controls had resistant strains. however, significantly more patients (64%) from nhs with large numbers of "skilled beds" had resistant bacteria than did patients from small nhs (21%) or controls (28%). also, more pa ...19853929707
assessment of head-space gas-liquid chromatography for the rapid detection of growth in blood cultures.blood for transfusion was inoculated with between 10(0) and 10(2) colony-forming units (cfu) per ml of each of 59 microbial isolates and added to cooked meat broth. at intervals up to 72 h incubation, the cultures were examined by conventional visual inspection and automated head-space gas-liquid chromatography (hs-glc). forty-six isolates including all those examined of staphylococcus aureus, streptococcus pyogenes, s. pneumoniae, s. faecalis, s. milleri, s. mitior, s. mitis, s. salivarius, s. ...19853988854
antibacterial activity of amifloxacin (win 49, 375), a new quinolone agent.the in vitro activity of amifloxacin, a quinolone antimicrobial agent was compared with those of ciprofloxacin, enoxacin, ofloxacin and norfloxacin against gram-positive and gram-negative bacteria. ninety percent of escherichia coli, klebsiella species, aeromonas, salmonella, shigella, citrobacter, enterobacter species, proteus mirabilis, serratia marcescens, and morganella morganii were inhibited by less than or equal to 0.5 microgram/ml. amifloxacin inhibited branhamella, haemophilus, and neis ...19854064609
population analysis of susceptibility to cefotaxime in enterobacteriaceae.population analysis of susceptibility to cefotaxime (ctx) in eight species of enterobacteriaceae was carried out. one strain of each species was examined. the strains represented their individual species as regards natural susceptibility to ampicillin (a) and carbenicillin (ca). cephalothinase activity of the parental strains and strains selected on the plates with the highest concentration that allowed growth was determined by an ultraviolet assay. the populations of the a-susceptible/ca-suscep ...19854083013
in vitro studies of bmy-28142, a new broad-spectrum cephalosporin.bmy-28142 was compared with other broad-spectrum antibiotics against gram-positive cocci and gram-negative bacilli. bmy-28142 was highly active against all gram-negative bacilli and especially against enterobacter cloacae, serratia marcescens, and morganella morganii. its in vitro activity suggests that bmy-28142 should prove to be useful for the treatment of gram-negative bacillary infections.19853838637
temocillin sensitivity of enterobacteriaceae species resistant to cefotaxime.the in vitro activity of temocillin, cefotaxime, aztreonam and ceftazidime was tested against selected cefotaxime-resistant isolates (43 enterobacter species, 37 serratia marcescens, 16 morganella morganii, 8 klebsiella species) and cefotaxime-susceptible strains of the same species. cross-resistance with a high degree of correlation was observed between cefotaxime and aztreonam or ceftazidime, but not between cefotaxime and temocillin.19853849423
timentin in the treatment of symptomatic complicated urinary tract infections in adult patients.the safety and effectiveness of timentin were evaluated in 34 adult patients with symptomatic complicated urinary tract infections, principally due to multiply-drug-resistant bacteria. although a wide variety of organisms, particularly gram-negative bacilli, were found, escherichia coli was the most frequent, accounting for 14 of 45 (31 percent) pathogens isolated. ten (22 percent) isolates were pseudomonas aeruginosa; 11 (24 percent) were proteus or morganella species; three (7 percent) were ci ...19853852637
in-vitro activity of ofloxacin, a quinolone carboxylic acid compared to other quinolones and other antimicrobial agents.ofloxacin is a new quinolone carboxylic acid compound. its activity against 900 bacterial isolates was determined. it inhibited 90% of escherichia coli, klebsiella sp., aeromonas hydrophila, salmonella spp., shigella spp., citrobacter spp., enterobacter spp., morganella morganii, proteus mirabilis, yersinia enterocolitica at less than or equal to 0.8 mg/l. branhamella catarrhalis, haemophilus sp., neisseria sp. were inhibited by less than or equal to 0.1 mg/l. pseudomonas aeruginosa and other ps ...19853865923
[therapeutic efficacies of suppository of ceftizoxime against experimental infections in mice].in experimental infections in mice, the therapeutic efficacies of rectal administration of ceftizoxime (czx) were compared with those of subcutaneous administration. the efficacies of rectal administration were equivalent to those of subcutaneous administration against intraperitoneal infections due to streptococcus pneumoniae and escherichia coli. against staphylococcus aureus, streptococcus pyogenes, klebsiella pneumoniae, enterobacter cloacae, proteus mirabilis, morganella morganii and serrat ...19853869265
gram-negative bacilli resistant to third-generation cephalosporins: beta-lactamase characterization and susceptibility to sch 34343.we studied 192 recent clinical isolates, comprising six species of gram-negative bacilli resistant either to cefotaxime or latamoxef (moxalactam), from several hospitals. all isolates were resistant to several other third-generation cephalosporins or a monobactam. two to five types of chromosomal beta-lactamases, as defined by isoelectric focusing, were readily identified in each species. isolates of citrobacter, enterobacter and serratia produced higher levels of chromosomal beta-lactamase than ...19853875602
in-vitro activity and beta-lactamase stability and inhibitory properties of a new penem antibiotic, sch 34343.sch 34343 is a new penem antibiotic. its in-vitro activity was determined against gram-positive and -negative aerobic and anaerobic isolates. sch 34343 inhibited 90% of strains of escherichia coli, klebsiella pneumoniae, proteus mirabilis, salmonella spp, citrobacter spp. and shigella spp. at less than 1 mg/1. ninety per cent of strains of enterobacter, morganella and providencia spp. were inhibited by less than 4 mg/1. sch 34343 did not inhibit pseudomonas spp., and it had slightly less activit ...19853875603
in-vitro activity of the combinations of ampicillin with mecillinam or with beta-lactamase inhibitors against strains resistant to ampicillin.the in-vitro activity of ampicillin, of mecillinam and of combinations of ampicillin with mecillinam, clavulanic acid or 6 beta-bromopenicillanic acid has been studied against 126 enterobacteriaceae resistant to ampicillin. the combination of ampicillin with mecillinam showed synergy or addition in 60% of the combinations tested. synergy was seen especially when the strains were resistant to mecillinam, indifference when they were susceptible to mecillinam. the combination of ampicillin with mec ...19853879248
the activity of cefbuperazone, a 7 alpha-methoxy 7 beta acyl ureido cephalosporin.the activity of cefbuperazone, a 7 alpha-methoxy ureido cephalosporin, was determined against 726 clinical isolates. ninety percent of escherichia coli, klebsiella pneumoniae, klebsiella oxytoca, citrobacter diversus, proteus mirabilis, enterobacter aerogenes, proteus vulgaris, morganella morganii, salmonella, and shigella species were inhibited by less than or equal to 6.3 micrograms/ml. cefbuperazone was more active than cefamandole, cefoxitin and piperacillin against these species. concentrat ...19853879464
aztreonam in the treatment of serious orthopedic infections.aztreozam was evaluated in the treatment of a variety of orthopedic infections. included were 17 patients with osteomyelitis, three with purulent arthropathy with prostheses, and 16 with superficial infections secondary to trauma or surgical procedure. pathogens were gram-negative bacilli sensitive to aztreonam. concomitant antibiotics were administered for gram-positive cocci that were present initially or by superinfection. infecting organisms included pseudomonas aeruginosa (minimal inhibitor ...19853881949
inducible xylitol dehydrogenases in enteric bacteria.morganella morganii atcc 25829, providencia stuartii atcc 25827, serratia marcescens atcc 13880, and erwinia sp. strain 4d2p were found to induce a xylitol dehydrogenase when grown on a xylitol-containing medium. the xylitol dehydrogenases were partially purified from the four strains, and those from m. morganii atcc 25829, p. stuartii atcc 25827, and s. marcescens atcc 13880 were all found to oxidize xylitol to d-xylulose. these three enzymes had kms for xylitol of 7.1 to 16.4 mm and molecular ...19853886639
inhibitory activity of cefpiramide on beta-lactamase.the beta-lactamase stability and inhibitory activity of cefpiramide were investigated. cefpiramide was found to be stable to hydrolysis and inhibited beta-lactamase produced by citrobacter freundii, enterobacter cloacae, morganella morganii, and escherichia coli. kinetic studies showed that cefpiramide is a competitive inhibitor of cephaloridine hydrolysis by e. cloacae beta-lactamase.19853888544
in vitro studies on the antibacterial activities of ym-13115, a new broad-spectrum cephalosporin.the in vitro antibacterial activities of ym-13115, a new parenteral cephalosporin, were compared with those of ceftazidime, cefoperazone, and cefsulodin. the compound was highly active against the common members of the enterobacteriaceae and 2 to 256 times more active than cefoperazone. ym-13115 was as active as ceftazidime against citrobacter freundii, proteus vulgaris, and morganella morganii and two to four times more active than ceftazidime against escherichia coli, klebsiella pneumoniae, en ...19853890729
sch 34343 activity against streptococci and beta-lactam-resistant enterobacteriaceae.the in-vitro activity of sch 34343 was compared with that of cefotaxime, ceftazidime, latamoxef (moxalactam), aztreonam and ampicillin. against pneumococci, sch 34343 was as active as ampicillin, whereas against the other streptococci it was less active than ampicillin but significantly better than the other antibiotics against enterococci. with clinical isolates of enterobacteriaceae resistant to cefotaxime, sch 34343 had mics generally less than 2 mg/l. after introduction of plasmid-mediated b ...19853897168
in vitro antibacterial activity of norfloxacin and other agents against ocular pathogens.302 clinical isolates representing 16 bacterial species most often implicated in ocular infections were tested in vitro against norfloxacin and a panel of antibacterial agents. on the basis of the 90% minimal inhibitory concentration (mic90) data, norfloxacin was 4-32 times more active than the next best antimicrobial tested against citrobacter freundii, escherichia coli, morganella morganii, proteus mirabilis, proteus vulgaris, haemophilus influenzae, neisseria gonorrhoeae and staphylococcus ep ...19853157551
[antigenic characteristics of standard strains of providencia rettgeri (o- and h-antigens)].additions and changes have been introduced into the existing antigenic diagnostic scheme of p. rettgeri on the basis of the study of the antigenic structure of standard strains from foreign collections: new, formerly unknown varieties of somatic and flagellar antigens (o35, o36, h27, h28) have been discovered, the complex of antigenic factors for h-antigens 7, 10, 23, 27 has been discovered. strains 958 (36 : 28) and 979 (16 : 27a, 23b, 2a), previously classified with the genus morganella, have ...19852416153
production of brownish pigment by bacteria of the morganella-proteus-providencia group.all bacteria of the morganella-proteus-providencia group tested produced a brownish pigment on agar containing l-forms of aromatic amino acids, i.e. histidine, phenylalanine, tryptophan, and tyrosine in the presence of iron ions under aerobic conditions. no pigment was observed without iron or when using d-forms of the amino acids. it is a melanin-like pigment with variable molecular weight under about 12000 d and an absorbance maximum between 330 and 410 nm depending on the concentration and th ...19853834717
imipenem/cilastatin in the treatment of intraabdominal infections: a review of worldwide experience.imipenem is a new broad-spectrum beta-lactam antibiotic, which when administered with cilastatin may be a suitable alternative to the combination of an aminoglycoside and either clindamycin or a nitroimidazole as therapy for intraabdominal infections. the clinical and microbiologic results for 164 assessable patients given imipenem/cilastatin for intraabdominal infections are reported. only three of 416 bacterial strains isolated prior to therapy from intraabdominal infection sites were resistan ...19853901215
evaluation of the in-vitro antibacterial activity of sch 34343.the in-vitro activity (as measured by geometric mean mics, mg/l) of sch 34343 against aerobic and anaerobic bacteria was compared with that of 14 other selected beta-lactam antibiotics including aztreonam, latamoxef (moxalactam), ceftazidime and imipenem. sch 34343 had good activity (less than 2 mg/l) against most gram-negative aerobic bacteria whether or not they contained high levels of plasmid-mediated or chromosomally-mediated beta-lactamases. it was slightly less potent against strains of m ...19853875604
purification and properties of a pyridoxal 5'-phosphate-dependent histidine decarboxylase from morganella morganii am-15.a pyridoxal 5'-phosphate-dependent histidine decarboxylase from morganella morganii am-15 was purified to homogeneity. the enzyme is a tetramer (mr 170,000) of identical subunits and binds 4 pyridoxal-p/tetramer; it is resolved by dialysis against cysteine at ph 6.8. between ph 6.2 and 8.8, the holoenzyme shows ph-independent absorbance maxima at 333 and 416 nm. vmax/km is highest at ph 6.5; this optimum reflects chiefly increased km values for histidine at lower or higher ph values, whereas vma ...19853997848
pyridoxal phosphate-dependent histidine decarboxylase from morganella am-15. 19863702683
pyridoxal 5'-phosphate-dependent histidine decarboxylase. inactivation by alpha-fluoromethylhistidine and comparative sequences at the inhibitor- and coenzyme-binding sites.pyridoxal phosphate-dependent histidine decarboxylase from morganella morganii am-15 was inactivated by (s)-alpha-fluoromethylhistidine by a pseudo first-order reaction, with ki and k inact values of 0.1 mm and 32.2 min-1, respectively, and was most efficient at ph 6.5-7.0. both l-histidine and the competitive inhibitor, l-histidine methyl ester, protected against inactivation. the apoenzyme was not inactivated. these findings indicate that inhibition is a mechanism-based process. under optimal ...19863733745
pyridoxal 5'-phosphate-dependent histidine decarboxylase. nucleotide sequence of the hdc gene and the corresponding amino acid sequence.the nucleotide sequence of a 1.3-kilobase naei fragment from morganella morganii am-15 that contains the gene for histidine decarboxylase has been determined. the gene was initially identified among total chromosomal digests using a mixed sequence oligonucleotide probe corresponding to amino acids 11-16 of histidine decarboxylase and then cloned on a 5.5-kilobase psti fragment. the structural gene contains 1131 nucleotides and encodes 377 amino acids with the sequence: (sequence: in text). the i ...19863015950
induction/inhibition of chromosomal beta-lactamases by beta-lactamase inhibitors.many species of gram-negative bacteria produce chromosomal beta-lactamases that can be induced to high-level expression by exposure to beta-lactam antibiotics. fifty-four strains of escherichia coli, enterobacter, proteus, citrobacter, and morganella were examined for beta-lactamase inducibility by clavulanic acid, sulbactam, ytr 830, ampicillin, and cefoxitin. cefoxitin proved to be the most potent inducer, affecting most of the strains of enterobacter and morganella. clavulanic acid induced 30 ...19863026004
epidemiology of aerobactin production in enterobacteriaceae.clinical isolates (496) of 10 different enterobacterial genera were studied for aerobactin excretion, colicin production and antibiotic resistance. in the case of escherichia coli, the incidence of aerobactin-positive strains in 108 blood isolates (45%) was not significantly different from that corresponding to faecal sources (41%). although colicin v production was much more frequently associated with aerobactin production than other colicins, colicin v was only produced by 26% of aerobactin ex ...19863318871
in vitro evaluation of a-56619 (difloxacin) and a-56620: new aryl-fluoroquinolones.the in vitro antibacterial potencies of a-56619 and a-56620, two new aryl-fluoroquinolones, were compared with the potency of norfloxacin against a broad spectrum of organisms. cefotaxime, aztreonam, piperacillin, imipenem, penicillin, and gentamicin were also tested for reference purposes. the mics required to inhibit at least 90% of the strains tested ranged from 0.25 to 4 micrograms/ml for a-56619 and from 0.06 to 0.5 microgram/ml for a-56620 for members of the enterobacteriaceae. a-56619 was ...19863087274
in vitro activity of aztreonam against gram negative bacteria from clinical specimens and its comparison with other commonly used antibiotics.a total of 755 gram negative bacteria isolated from clinical specimens were tested against aztreonam by the disc agar diffusion test. the strains of bacteria used in this study consisted of escherichia coli (314), enterobacter aerogenes (30), e. agglomerans (7), e. cloacae, (39), citrobacter diversus (9), c. freundii (13), hafnia alvei (3), acinetobacter calcoaceticus (10), klebsiella oxytoca (6), k. ozaenae (5), k. pneumoniae (107), morganella morganii (3), moraxella sp. (10), pasteurella multo ...19863088346
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