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morganella morganii: epidemiology of bacteremic disease.a retrospective review of microbiology records revealed 19 documented episodes of m. morganii bacteremia in 18 patients at a veterans administration hospital during a 5.5 year period. thirteen of 19 bacteremias were related to nosocomial infections; 11 of the 13 nosocomial bacteremias occurred in surgical patients. nine of the 13 patients with nosocomial bacteremia had received recent therapy with a beta-lactam antibiotic. the most common source of bacteremia was a postoperative wound infection ...19846561180
treatment of experimental chronic osteomyelitis caused by morganella morganii with mezlocillin and cloxacillin.mezlocillin was used alone and in combination with cloxacillin in the treatment of chronic experimental osteomyelitis due to morganella morganii. this combination showed in vitro synergy as measured by the checkerboard technique. a marked inoculum affect was demonstrated in vitro with mezlocillin and the infecting strain of m. morganii. in therapeutic trials, mezlocillin administered for 28 days was totally ineffective. the combination of mezlocillin and cloxacillin (at 800 and 400 mg/kg, respec ...19846563980
in vitro antagonism between n-formimidoyl thienamycin and aztreonam, ticarcillin and ticarcillin/clavulanic acid.one-hundred eighty-seven bacterial strains were tested by the two-disk-agar diffusion method for the interaction between n-formimidoyl thienamycin and aztreonam, ticarcillin and ticarcillin-clavulanic acid. an antagonism between n-formimidoyl thienamycin and the other 3 beta-lactams was noted in half of the evaluable tests, especially against pseudomonas, escherichia coli and morganella.19846594965
influence of spontaneous and inducible beta-lactamase production on the antimicrobial activity of recently developed beta-lactam compounds.the activity of 9 recently developed beta-lactam compounds was evaluated in 185 ampicillin-resistant isolates of enterobacteriaceae. moreover, in all strains, spontaneous and inducible beta-lactamase production was quantified and correlated with the minimal inhibitory concentration (mic) of each compound. in most species, no correlation could be observed between spontaneously produced beta-lactamase and the mics, with the only exceptions of serratia spp. and morganella morganii isolates for meth ...19846610539
the effect of piperacillin prophylaxis on the colonic microflora in patients undergoing colorectal surgery.piperacillin was given parenterally in doses of 4 g every 8 h for two days to 20 patients undergoing colorectal surgery. a series of serum and fecal specimens were taken to analyse piperacillin concentrations. tissue samples from the gut wall were taken during surgery. the maximum serum concentrations during surgery were reached 15 min after piperacillin administration. on day 0 the mean half-life was 1.9 h and the mean area under the serum concentration curve was 536.8 mg/l. the piperacillin co ...19836642676
effect of 7 alpha substitution of cephems on their beta-lactamase stability and affinity for penicillin-binding proteins in morganella morganii.cephamycins, which have a methoxy group at the 7 alpha position of their cephalosporin nuclei, were highly stable against hydrolysis by a beta-lactamase purified from a clinical isolate of morganella morganii, whereas their 7 alpha-h analogs were rapidly hydrolyzed by the enzyme. the high stability of the cephamycins was not due to their low affinity for the enzyme, since the cephamycins strongly inhibited the enzyme in a competitive manner. in cases in which the 7 alpha-methoxy group was substi ...19836602587
nonspecific induction of beta-lactamase in enterobacter cloacae.since the introduction of the new beta-lactamase-stable beta-lactam compounds, inducible beta-lactamases have become increasingly important clinically [1]. it has recently been pointed out that most beta-lactam antibiotics appear to be affected by these derepressed enzymes either by hydrolysis or by the nonhydrolytic barrier mechanism [2]. until now, it has generally been assumed that beta-lactamases are induced only by the beta-lactam compounds themselves. we investigated an e cloacae strain th ...19836605393
in vitro antibacterial activity and beta-lactamase stability of e-0702, a new cephalosporin.the in vitro activity of e-0702 was compared with the in vitro activity of cefotaxime, ceftazidime, moxalactam, and aztreonam against 600 gram-positive and gram-negative aerobic and anaerobic isolates. e-0702 had a minimal inhibitory concentration for 50% of isolates (mic50) of 25 micrograms for staphylococcus aureus, 50 micrograms for staphylococcus epidermidis, and 1.6 to 3.1 micrograms for streptococci, with streptococcus faecalis resistant. e-0702 had mic50s against escherichia coli, klebsie ...19836605718
comparative activity of cefotetan on escherichia coli k12 possessing plasmid-mediated beta-lactamases.the antibacterial activity of cefotetan, a new cephamycin, was compared with that of cephalothin, cefoxitin, cefamandole, cefoperazone and cefotaxime on 12 substrains of escherichia coli k12 bm13 harbouring single and multi-copy plasmids coding for plasmid-mediated beta-lactamases tem, shvi, oxa-i and oxa-iii. the 99% inhibitory concentrations (ic99) for the recipient strain were increased in proportion to the enzyme activity in the case of cefamandole and cefoperazone. in contrast, the activity ...19836341349
serious nosocomial infection caused by morganella morganii and proteus mirabilis in a cardiac surgery unit.in july and august 1981, five patients in the cardiac surgery unit of the bristol royal infirmary developed septicemia caused by morganella morganii, proteus mirabilis, or both of these species. three of the patients had serious wound infections, and three of the patients died. typing of the m. morganii isolates by o-serotyping and of the p. mirabilis isolates by o-serotyping, proticine production and sensitivity, and the dienes reaction confirmed cross infection by both species. although m. mor ...19836350354
beta-lactamase inhibitory activity of iodopenicillanate and bromopenicillanate.iodopenicillanate and bromopenicillanate were shown to be effective inhibitors of a variety of beta-lactamases. staphylococcus aureus isolates were synergistically inhibited by iodopenicillanate and bromopenicillanate combined with ampicillin. methicillin-resistant s. aureus was not synergistically inhibited. escherichia coli which possessed tem beta-lactamase activity had a reduction in ampicillin minimal inhibitory concentration, but an e. coli isolate which had chromosomal beta-lactamase and ...19836299186
comparison of the lipoprotein gene among the enterobacteriaceae. dna sequence of morganella morganii lipoprotein gene and its expression in escherichia coli.a dna sequence of 532 base pairs encompassing the entire morganella morganii lipoprotein gene (lpp) was determined. sequence comparisons of the m. morganii lpp gene with the lpp genes from escherichia coli, serratia marcescens, and erwinia amylovora reveal that the m. morganii lpp gene is more distantly related to the e. coli lpp gene than any of the other lpp genes examined. between the e. coli and m. morganii lpp genes, the following homologies were found: 44% in the promoter region (bases, -4 ...19836305973
[in vitro bacteriostatic activity of cefmenoxime (sce 1365), cefotaxime and moxalactam].the in vitro activity of cefmenoxime (sce 1365), a new cephalosporin derivate was compared with two other "third generation" cephalosporins: cefotaxime and moxalactam. cefmenoxime as cefotaxime and moxalactam were very active against 305 cephalosporinase-producing and cephalosporinase-non-producing enterobacteriaceae. cefmenoxime was the most active against serratia marcescens, citrobacter freundii, morganella morganii, salmonella, shigella and yersinia enterocolitica with a mean mic at least tw ...19836312395
[antibiotic activity and synergism of ceftazidime and netilmicin against gram-negative pathogenic bacteria].the in vitro activity of ceftazidime and netilmicin against gram-negative bacteria often causing hospital infections was evaluated and furthermore synergistic effects of these antibiotics were studied. ceftazidime was as active as netilmicin against enterobacteriaceae, e.g. enterobacter, klebsiella, morganella inhibiting 90% of these strains at concentrations from 0.5 to 4 micrograms/ml. ceftazidime was the most effective agent against pseudomonas aeruginosa, being even more active than cefsulod ...19836320836
in-vitro synergism between mezlocillin and isoxazolyl penicillins against beta-lactamase-producing gram-negative organisms.forty beta-lactamase producing gram-negative organisms were tested with mezlocillin plus an isoxazolyl penicillin for synergy. with standard chequerboard techniques, the combination showed enhanced activity, when compared to either drug alone, against 30 strains. eighteen of these 30 strains showed synergism at concentrations of mezlocillin and isoxazolyl penicillins which were attainable in the serum (7 strains of morganella morganii, 8 strains of eschericia coli and 3 strains of serratia marce ...19836222024
in vitro activity of enoxacin, a quinolone carboxylic acid, compared with those of norfloxacin, new beta-lactams, aminoglycosides, and trimethoprim.enoxacin is a new quinolone carboxylic acid compound. its activity against 740 bacterial isolates was determined. it inhibited 90% escherichia coli, klebsiella sp., aeromonas sp., enterobacter spp., serratia spp., proteus mirabilis, and morganella morganii at less than or equal to 0.8 micrograms/ml. the majority of pseudomonas aeruginosa was inhibited by less than or equal to 3.1 micrograms/ml. haemophilus spp. and neisseria spp. were inhibited by less than 0.1 micrograms/ml. although most staph ...19836229216
the in-vitro activity of o-demethylfortimicin.the activity of o-demethylfortimicin against ampicillin, cefazolin and carbenicillin resistant bacteria was determined. o-demethylfortimicin showed excellent in-vitro activity against escherichia coli, klebsiella pneumoniae, enterobacter cloacae, ent. agglomerans, ent. aerogenes, citrobacter freundii, proteus vulgaris, morganella, and providencia inhibiting these organisms at less than or equal to 3.1 mg/l. it was particularly effective against ent. cloacae and serratia marcescens that were resi ...19836833173
bacteriological studies of the enteric flora of patients treated with bicozamycin (cgp 3543/e) for acute nonparasitic diarrhea.during a therapeutic trial of bicozamycin (bi) for traveler's diarrhea, aerobically grown, gram-negative bacteria, predominantly escherichia coli, were decreased by 2 to 3 logs per g of stool; the number of bi-resistant gram-negative bacteria did not increase. resistant species were most often citrobacter freundii, klebsiella pneumoniae, and morganella morganii, and few bi-resistant e. coli strains were isolated. cross-resistance between bi and other antimicrobial agents was not found. resistanc ...19836859842
antibacterial activity and beta-lactamase stability of ceftazidime, an aminothiazolyl cephalosporin potentially active against pseudomonas aeruginosa.the in vitro activity and beta-lactamase stability of ceftazidime were evaluated against 700 gram-positive and gram-negative bacteria. ceftazidime was less active than penicillins or older cephalosporins against staphylococcus spp. and streptococcus spp., and it did not inhibit streptococcus faecalis, listeria, or anaerobic species. ceftazidime was as active as ceftizoxime and moxalactam and more active than cefoperazone against escherichia coli. klebsiella, and proteus mirabilis with minimal in ...19826805421
in vitro activity and beta-lactamase stability of cefmenoxime.the activity of cefmenoxime, an aminothiazolyl cephalosporin, was studied against 650 bacteria. it was slightly less active than cefotaxime and more active than moxalactam against staphylococci. it had activity similar to that of cefotaxime and ceftizoxime against group a and b streptococci and streptococcus pneumoniae. it did not inhibit streptococcus faecalis or listeria spp. cefmenoxime had activity similar to that of cefotaxime, ceftizoxime, ceftazidime, and moxalactam against escherichia co ...19826100427
haemagglutinins and fimbriae of morganella, proteus and providencia.one hundred and thirteen strains of morganella, proteus and providencia, grown in different cultural conditions, were examined for their ability to produce haemagglutinins (has). three main kinds of ha (ms, mr/k and mr/p) were detected, and 89% of the 112 ha+ strains were capable of producing two or three of the different has in the same or different cultures. the properties of the three has were partly defined and the difficulties of identifying their separate ha activities when present togethe ...19826129324
in vitro activity of norfloxacin, a quinolinecarboxylic acid, compared with that of beta-lactams, aminoglycosides, and trimethoprim.norfloxacin is a quinolinecarboxylic acid compound. we examined the in vitro activity of this compound against gram-positive and -negative species, including anaerobic species. it inhibited 90% (mic90) of strains of escherichia coli at 0.05 microgram/ml, klebsiella sp. at 0.4 microgram/ml, salmonella and shigella spp. at 0.1 microgram/ml, citrobacter sp. at 0.4 microgram/ml, enterobacter cloacae at 0.2 microgram/ml, enterobacter aerogenes at 0.4 microgram/ml, and enterobacter agglomerans at 0.2 ...19826214995
synergistic activity of mecillinam in combination with the beta-lactamase inhibitors clavulanic acid and sulbactam.the beta-lactamase inhibitors clavulanic acid and sulbactam were combined with mecillinam. beta-lactamase-containing escherichia coli resistant to mecillinam was synergistically inhibited by both clavulanic acid and sulbactam. beta-lactamase-containing enterobacter was synergistically inhibited, but strains lacking beta-lactamases were not synergistically inhibited. synergistic inhibition was noted for beta-lactamase-containing, mecillinam-resistant klebsiella, citrobacter, serratia, and salmone ...19826291454
cefotaxime: a review of in vitro antimicrobial properties and spectrum of activity.cefotaxime has remarkable potency against all enterobacteriaceae, including enterobacter species, citrobacter freundii, serratia marcescens, and morganella morganii, proteus vulgaris, and providencia species--all of which are resistant to earlier cephalosporins. cefotaxime generally inhibits greater than 90% of enteric bacilli at concentrations of less than or equal to 0.5 microgram/ml; in one study it inhibited greater than 98% of isolates at less than or equal to 8 micrograms/ml. for staphyloc ...19826294779
antimicrobial activity of desacetylcefotaxime alone and in combination with cefotaxime: evidence of synergy.the level of antimicrobial activity of 3-desacetylcefotaxime was found to be approximately eightfold lower than that of cefotaxime. variation in the inhibitory effects of desacetylcefotaxime was species dependent. desacetylcefotaxime was 1-2 log2 dilutions more active than cefotaxime against pseudomonas acidovorans and pseudomonas cepacia. desacetylcefotaxime and cefotaxime were bactericidal, and their minimal inhibitory concentrations were influenced only slightly by increases in the inoculum c ...19826294785
antibacterial activity of desacetylcefotaxime alone and in combination with cefotaxime.cefotaxime is metabolized to 3-desacetylcefotaxime. the antibacterial activity of desacetylcefotaxime is four- to eightfold less than that of cefotaxime. the activity of desacetylcefotaxime is species- and strain-specific. although desacetylcefotaxime is less active than cefotaxime, it is more active than cefazolin, cefamandole, or cefoxitin. desacetylcefotaxime does not inhibit many strains of morganella, most strains of pseudomonas aeruginosa, some strains of serratia marcescens, some strains ...19826294786
treatment of urinary tract infections with cefotaxime: noncomparative and prospective comparative trials.three studies evaluated the efficacy of cefotaxime for the treatment of urinary tract infections. an open, multicenter, noncomparative trial included 477 patients who received a usual dose of 2 g of intravenous or intramuscular cefotaxime daily for five to 10 days. the maximal daily dosage in severe cases was 12 g. pathogens included escherichia coli and species of citrobacter, pseudomonas, klebsiella, enterobacter, serratia, morganella, providencia, and proteus. of all the causative organisms, ...19826294793
reliability of early identifications obtained with enterobacteriaceae-plus biochemical cards in the automicrobic system.the automicrobic system (ams) is capable of identifying most enterobacteriaceae within 8 h and many glucose-nonfermenting, gram-negative bacilli after 13 h of incubation. early preliminary results can be readily obtained from the computer as the tests incubate. data with 1,023 bacterial isolates were reviewed to determine the relative accuracy of 4-, 6-, 8-, 10-, and 13-h identifications. all automicrobic system identifications with probability (p) values of less than 0.80 were considered equivo ...19826749890
comparison of three methods for identification of enterobacteriaceae.this study compares the ability of three commercial overnight methods, api 20e, minitek and enteric-tek, to accurately and completely identify 368 clinically isolated enterobacteriaceae without supplemental tests. organisms included escherichia coli (54 strains), shigella spp. (7), edwardsiella tarda (1), salmonella enteritidis (10), citrobacter spp. (30), klebsiella spp. (55), enterobacter spp. (68), hafnia alvei (2), serratia spp. (33), proteus spp. (64), morganella morganii (24), providencia ...19826756905
comparison of micro-id and api 20e in rapid identification of enterobacteriaceae.the effectiveness of micro-id and api 20e as same-day identification systems for enterobacteriaceae was evaluated in comparison with conventional identification by using 315 clinical isolates and 90 stock strains. the api 20e system was heavily inoculated according to manufacturer's recommendations for same-day identification. we found that 83 and 81% of isolates provided adequate inocula for micro-id and api 20e, respectively, and purity of the heavy inocula was not a problem with either system ...19827047556
penem derivatives: beta-lactamase stability and affinity for penicillin-binding proteins in escherichia coli.penem derivatives, a new group of beta-lactam antibiotics with potent activities against a wide range of bacteria, including pseudomonas aeruginosa, were tested for their stability against hydrolysis by beta-lactamases purified from clinical isolates of morganella morganii. proteus vulgaris, and escherichia coli and by a penicillinase from bacillus cereus. penems having 6 alpha substituents, such as hydroxyethyl, hydroxymethyl, and ethyl groups, were very stable against hydrolysis by each of the ...19827049076
comparison of two methods for same-day identification of enterobacteriaceae.two commercial methods, api 20e (as modified for same-day enterobacterial identification) and micro-id, were evaluated for ability to provide useful same-day information of 368 clinically isolated enterobacteriaceae. organisms included escherichia coli (54), shigella (7), edwardsiella tarda (1), salmonella enteritidis (10), citrobacter (30), klebsiella (55), enterobacter (68), hafnia alvei (2), serratia (33), proteus (64), morganella morganii (24), providencia (18), and yersinia enterocolitica ( ...19827051807
hand carriage of aerobic gram-negative rods by health care personnel.a quantitative culture technique (hand washed in a glove containing broth for 30 s) was used to determine the frequency of hand carriage of aerobic gram-negative rods by various groups of health care workers and 104 control subjects. overall, 31% of health care workers carried aerobic gram-negative rods on their hands compared to 59% of control subjects (p < 0.001). enterobacter agglomerans accounted for 40% of the isolates, and other enterobacter spp. 7%. other organisms included acinetobacter ...19827097001
[antibiograms in ambulatory medical practice. results with a group of gram-negative bacilli strains isolated by uroculture].during the april 1979--june 1978 period, 1161 tests were carried out on the sensitivity to antibiotics and chemotherapeutical agents of gram-negative bacillus strains isolated from 7632 urocultures. resistance was tested under qualitative control against 13 antimicrobial agents by the kirby-bauer diffusimetric method. the resistance sensitivity and the presence of intermediary strains is shown for e. coli citrobacter, enterobacter, klebsiella, proteus, morganella, providencia, and pseudomonas. a ...19827156696
hospital cluster epidemic with morganella morganii.a cluster epidemic of 13 morganella morganii infections involving 11 patients occurred over a 3-month period in 1977. this epidemic was unusual in that it involved four services and five hospital floors. the outbreak was effectively terminated when strict asceptic techniques were reinforced.19817309851
worldwide clinical experience with cefoperazone.the safety and clinical efficacy of cefoperazone 1 to 2g 12-hourly was evaluated in clinical trials conducted in the united states, europe, south and latin america, and japan. 1046 patients were treated in 4 comparative and 9 non-comparative studies. an overall satisfactory clinical response for cefoperazone therapy was achieved in 540 (88%) of the 615 evaluable patients. cefoperazone was effective in 92% of lower respiratory tract infections, 81% of urinary tract infections, 98% of gynaecologic ...19816456884
in vitro antimicrobial activity evaluation of cefodizime (hr221), a new semisynthetic cephalosporin.cefodizime (hr221) is a new alpha-methoxyimino cephalosporin developed by hoechst-roussel with a reported serum half-life of over 2 h. in vitro susceptibility studies showed that the cefodizime spectrum includes all those enterobacteriaceae, staphylococci, streptococcus spp., haemophilus spp., and neisseria spp. normally susceptible to cefotaxime (hr756) or ceftizoxime (fk749) or both. cefodizime was less active (two- to eightfold) than cefotaxime or ceftizoxime against some enteric species, but ...19816275785
in-vitro activity of ceftazidime, a beta-lactamase stable cephalosporin.the in-vitro activity and beta-lactamase stability of ceftazidime were evaluated against 700 gram-positive and gram-negative bacteria. ceftazidime was less active than penicillins or older cephalosporins against staphylococcus spp. and streptococcus spp., and it did not inhibit streptococcusfaecalis. however, ceftazidime was as active as moxalactam and cefoperazone against escherichia coli, klebsiella and proteus mirabilis with mics less than 0.2 mg/l. ceftazidime also inhibited enterobacter, ci ...198119810175
unusual groups of morganella ("proteus") morganii isolated from clinical specimens: lysine-positive and ornithine-negative biogroups.morganella ("proteus") morganii is the only species in the recently proposed genus morganella, but we suspect there are yet undescribed species in the genus. two candidates for new species were recently investigated. nineteen strains isolated from clinical specimens resembled m. morganii but were lysine positive and nonmotile and fermented glycerol within 24 h. typical m. morganii are lysine negative and motile and ferment glycerol slowly or not at all. the three-test variance from typical m. mo ...19806775010
evaluation of the four-hour micro-id technique for direct identification of oxidase-negative, gram-negative rods from blood cultures.a 4-h micro-id technique for direct identification of oxidase-negative gram-negative rods from positive blood cultures was compared to subculture and species identification of single colonies by api 20e and micro-id, using standardized inocula. a total of 127 patients (220 positive cultures) were studied. isolates included 96 escherichia coli, 46 klebsiella pneumoniae, 7 klebsiella oxytoca, 8 enterobacter aerogenes, 17 enterobacter cloacae, 19 serratia marcescens, 2 serratia liquefaciens, 8 prot ...19806999020
o antigen grouping of morganella morganii (proteus morganii) by slide agglutination.antisera were prepared against morganella morganii (proteus morganii) type strains from the scheme described by rauss et al. (acta microbiol. acad. sci. hung. 22:315--321, 1975) and raus and vörös (acta microbiol. acad. sci. hung. 6:233--248, 1959; acta microbiol. acad. sci. hung. 14:195--198, 1967). the specificities of the somatic (o) antigens were studied using the passive hemagglutination and slide agglutination techniques. previously unreported interstrain relations were observed, and o gro ...1979500798
[bacteria of the genus morganella]. 1976782106
antigenic relationship between morganella morganii and yersinia enterocolitica.two new o antigens have been described for the morganella morganii antigenic schema. o antigens of the strains representing the new serotypes (o43 :h2 and o44 : h19, 37) are related to yersinia enterocolitica o9 and o17, respectively.197659520
[microbiological characteristics of bacteria of the genera proteus and morganella isolated from ill and healthy children]. 19751094728
[in vitro examination on antibacterial activities of broad-spectrum antibiotics against gram-negative clinical isolates (author's transl)].in vitro studies were undertaken on clinically isolated strains of various bacteria to examine the antibacterial activity of ampicillin (ab-pc), carbenicillin (cb-pc), sulbenicillin (sb-pc) cephalothin (cet), cefazolin (cez) and gentamicin (gm). fifty three % of escherichia coli strains 53.3% of citrobacter sp., 80% of proteus mirabilis, 42.9% of morganella and 80% of bacteroides sp. were susceptible (mic being not higher than 12.5 mug/ml) to ab-pc. the eight other species were not so susceptibl ...19751104913
new serotypes of morganella morganii.on the basis of 8 new o and 11 new h antigens determined in 22 strains, the morganella morganii antigenic schema was supplemented with 8 serogroups (o35-o42) and 13 serotypes. four strains belonged to o groups described earlier and 2 strains contained new o antigens in combination with known o antigens. known h antigens were present in one strain as a single factor and in one strain as combination of two factors. new h antigens were demonstrated in 5 serotypes in combination with known h antigen ...19751155231
[characteristics of the klebsiella, proteus and morganella isolated from infants with acute gastrointestinal diseases]. 19744463338
serological relationship between pseudomonas aeruginosa and enterobacteriaceae. ii. relationship of pseudomonas aeruginosa o antigens to escherichia, shigella, proteus, morganella, rettgerella and providencia. 19734205984
[candida albicans (ch. robin, 1853), pseudomonas aeruginosa (schroeter, 1872), and morganella morgani (winslow et al., 1919), proofs of organic decline]. 19724628508
morganella morganii antigenically related to escherichia coli 0111: k58(b4). 19674860403
five new serotypes of morganella morganii. 19676048149
antigenic relationships between morganella morganii and different genera of enterobacteriaceae. 19676048150
distribution and activity of histidine decarboxylase in morganella. 195813575010
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