TitleAbstractYear(sorted ascending)
inducible type i beta-lactamases of gram-negative bacteria and resistance to beta-lactam antibiotics.mutants, showing either constitutive (depressed) or non-inducible expression of chromosomally-mediated type i beta-lactamase were obtained from clinical isolates of enterobacter cloacae, ent. aerogenes, citrobacter freundii, providencia stuartii, morganella morganii, serratia marcescens and pseudomonas aeruginosa. the wild-type and mutant strains were compared for susceptibility to a range of beta-lactam antibiotics. derepression of beta-lactamase synthesis generally, but not always, resulted in ...19863485092
antimicrobial activity and beta-lactamase stability of sk&f 88070 compared with other agents.the in vitro activity and beta-lactamase stability of sk&f 88070 (7-[[2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[ [1-(2-sulfaminoethyl)-1h-tetrazol-5-yl]thio]methyl]-3- cephem-4-carboxylic acid) a new parenteral cephalosporin was investigated against 780 types of bacteria. sk&f 88070 inhibited 90% of escherichia coli, klebsiella pneumoniae, proteus mirabilis, salmonella species, shigella species, morganella morganii, and citrobacter diversus at less than or equal to 0.5 micrograms/ml. i ...19863485506
the activity of bmy 28142 a new broad spectrum beta-lactamase stable cephalosporin.the in-vitro activity of bmy 28142, an iminomethoxy, aminothiazolyl cephalosporin containing a methyl pyrrolidinio c-3 was compared with that of cefotaxime, ceftazidime, aztreonam, imipenem and tobramycin against various bacteria. bmy 28142 was the most active agent tested against the enterobacteriaceae inhibiting 90% at less than or equal to 1 mg/l. the in-vitro activity of bmy 28142 was equal to or superior to cefotaxime against the highly susceptible members of the enterobacteriaceae and seve ...19863486862
gram-negative septicemia in american alligators (alligator mississippiensis).six species of bacteria (family enterobacteriaceae) not commonly reported as associated with disease in american alligators (alligator mississippiensis) were documented, suggesting that aeromonas is not the only bacterium responsible for septicemia in crocodilians. these included citrobacter freundii, enterobacter agglomerans, proteus sp., morganella morganii, serratia marcescens, and klebsiella oxytoca. clinical signs of disease included intensive basking, anorexia, lethargy, flaccid limb paral ...19863503133
rare occurrence of proteus vulgaris in faeces: a reason for its rare association with urinary tract infections.the faecal carriage rates of different species of proteeae were assessed in studies with 220 faecal isolates from 219 individuals of whom approximately one-third were well and the remainder had gastro-enteritis. as a result of the development of new media that allowed replacement of the phenylalanine deaminase test with the tryptophan deaminase test and made it possible to combine tests for indole and urease production and for hydrogen sulphide and ornithine decarboxylase formation in two single ...19863512839
occurrence and pathogenic role of morganella-proteus-providencia group bacteria in human feces.a total of 2,693 fecal specimens, with 1,422 from healthy persons and 1,271 from patients suffering from enteric diseases, was investigated to isolate species of the morganella-proteus-providencia group and to evaluate the role of these bacteria in intestinal disorders. most strains were isolated from two media, i.e., blood agar and tryptophan agar. two of the species were more frequently found in diarrheal cases than in healthy controls. these species were morganella morganii and proteus mirabi ...19863517057
effect of inoculum size on ampicillin and amoxycillin susceptibility determined by gas-liquid chromatography for members of the family enterobacteriaceae.inoculum size had only a small effect on the results for ampicillin and amoxycillin susceptibility testing of escherichia coli. in contrast, a difference in inoculum size from 10(6) to 10(8) cfu/ml profoundly affected the results for ampicillin and amoxycillin susceptibility testing of proteus mirabilis, causing a change from susceptibility to complete resistance. these different effects of inoculum size were observed both when susceptibility was determined by the suppression of a characteristic ...19863517063
ferric ammonium citrate decomposition--a taxonomic tool for gram-negative bacteria.the iron uptake test of szabó and vandra has been modified and used for the differentiation of gram-negative bacteria. nutrient agar containing 20 g per litre of ferric ammonium citrate was distributed into narrow tubes and solidified so as to form butts and slants. considering the localization of the rusty-brown coloration produced after seeding and incubation, 2367 strains were classified into four groups. (1) unchanged medium: escherichia coli, shigella spp., yersinia spp., hafnia alvei and m ...19863529797
[inhibition of cephalosporinase of enterobacteria by ceftriaxone].resistance of ceftriaxone, cefotaxime and cefmenoxime to inactivation by the chromosomal constitutive cephalosporinases of enterobacter cloacae p99, morganella morganii gn 1510 and serratia liquefaciens 132 was determined using high performance liquid chromatography. the inhibitory properties of ceftriaxone against the same cephalosporinases were studied by determining the residual amount of cephalothin used as the substrate. with a 1:50 cephalosporinase-cephalosporin ratio, ceftriaxone was less ...19863534712
[bactericidal activity of ceftriaxone, amikacin and their combination].third-generation cephalosporins such as ceftriaxone are often used alone; however, with enterobacter (ent), citrobacter (cit), serratia (ser) and morganella (mor), a combination of two drugs is advisable. aminoglycoside-beta-lactam combinations are often synergistic. however, results are not consistent with the new cephalosporins. we determined the killing kinetics of ceftriaxone (c) alone, amikacin (a) alone and both drugs in combination (ac). the antibiotics were tested in the following concen ...19863534741
speciation, serotyping, antimicrobial sensitivity and plasmid content of proteeae from the environment of calf-rearing units in south west england.a survey was undertaken of the occurrence, serotype, antimicrobial sensitivity and plasmid content of members of the tribe proteeae in the environment of two calf-rearing units in the county of avon in south west england. examples of the following species were found: proteus mirabilis, prot. vulgaris, prot. vulgaris biogroup 2, morganella morganii, providencia stuartii, prov. alcalifaciens and prov. rettgeri. a wide range of serotypes was found, many having been previously reported from nosocomi ...19863540110
selective and differential medium for the primary isolation of members of the proteeae.a new differential and selective medium for the isolation of members of the proteeae, pim (proteeae isolation medium) agar, was developed and evaluated. the medium relies on the ability of all members of the proteeae (with the exception of a very few morganella morganii strains) to produce a dark brown pigment in medium containing dl-tryptophan. an additional differential property, tyrosine degradation, was also demonstrated by the medium. members of the proteeae appeared as dark brown colonies ...19863958148
susceptibility of ticarcillin-resistant gram-negative bacilli to different combinations of ticarcillin and clavulanic acid.the susceptibility of ticarcillin-resistant and of ticarcillin-susceptible gram-negative bacilli to different combinations of ticarcillin and clavulanic acid has been investigated. susceptibility to ticarcillin has been restored in ticarcillin-resistant isolates in proportion to the amount of clavulanic acid in the combination and depending upon the species. the decrease in the mics of ticarcillin was excellent to good in proteus, morganella, providencia, escherichia coli and klebsiella, moderat ...19863636338
pyridoxal phosphate-dependent histidine decarboxylase from morganella am-15. 19863702683
in vitro activity of ci-934, a new quinolone, compared with that of other quinolones and other antimicrobial agents.the in vitro activity of ci-934, a new 4-quinolone, was determined against gram-positive and gram-negative bacteria. the mics for 90% of the isolates tested were 0.25 microgram/ml for streptococcus pneumoniae, 0.5 microgram/ml for streptococcus faecalis, 0.25 microgram/ml for staphylococci, including methicillin-resistant strains, and less than or equal to 1.0 microgram/ml for escherichia coli, salmonella and shigella spp., klebsiella spp., proteus spp., and citrobacter spp. ci-934 had activity ...19863729343
in vitro activity of ro 15-8074 and ro 19-5247, two orally administered cephalosporin metabolites.the activity of two iminomethoxy aminothiazoly cephalosporins, ro 15-8074 and ro 19-5247, was compared with that of other beta-lactams against a total of 491 bacterial strains. both were highly active (mic for 90% of the strains tested [mic 90], less than or equal to 2 micrograms/ml) against the majority of the members of the family enterobacteriaceae, haemophilus influenzae, neisseria spp., and streptococcus pneumoniae, being at least 16-fold more active than cephalexin and 8-fold more active t ...19863729361
pyridoxal 5'-phosphate-dependent histidine decarboxylase. inactivation by alpha-fluoromethylhistidine and comparative sequences at the inhibitor- and coenzyme-binding sites.pyridoxal phosphate-dependent histidine decarboxylase from morganella morganii am-15 was inactivated by (s)-alpha-fluoromethylhistidine by a pseudo first-order reaction, with ki and k inact values of 0.1 mm and 32.2 min-1, respectively, and was most efficient at ph 6.5-7.0. both l-histidine and the competitive inhibitor, l-histidine methyl ester, protected against inactivation. the apoenzyme was not inactivated. these findings indicate that inhibition is a mechanism-based process. under optimal ...19863733745
production and degradation of indole by gram-negative bacteria.the indole reaction is performed in various modifications with regard both to the reagents and to the media used. especially the medium has hitherto attracted little attention and there are divergent recommendations for its composition. the comparison of some broths without and with addition of tryptophan after incubation with different indole-positive species revealed that tryptone without tryptophan yielded stronger reactions than with tryptophan added. other broths showed stronger reactions w ...19863754676
the effect of the combination of erythromycin with new beta-lactam antibiotics against gram-negative aerobic respiratory pathogens.the effect of erythromycin on the in vitro activity of cefotaxime, ceftizoxime, cefoperazone, moxalactam, ceftazidime, cefmenoxime, aztreonam, imipenem, piperacillin, and gentamicin against 89 bacteria isolated from sputum and tracheal aspirates of patients admitted to intensive care units was evaluated. there were 30 pseudomonas aeruginosa, 27 klebsiella pneumoniae, 9 enterobacter cloacae, 5 escherichia coli, 4 enterobacter aerogenes, 3 each of klebsiella oxytoca, pseudomonas maltophilia, serra ...19863802298
head-space gas-liquid chromatographic analysis for presumptive identification of bacteria in blood cultures.a total of 445 strains of common aerobic and anaerobic bacteria were analyzed for their volatile microbial metabolites by head-space gas-liquid chromatography. the bacteria were incubated for 24 or 48 h in blood-containing trypticase soy or lombard-dowell glucose broth before being analyzed by automatic head-space injection. from the chromatographic pattern obtained, the majority of klebsiella pneumoniae, enterobacter cloacae, serratia marcescens, escherichia coli, pseudomonas aeruginosa, morgan ...19863816354
rapid catalase supplemental test for identification of members of the family enterobacteriaceae.a simple, rapid, semiquantitative slide catalase test useful for differentiating members of the family enterobacteriaceae is described. judging by the time required for appearance of oxygen bubbles in 3% hydrogen peroxide, the immediate catalase reactors were yersinia, serratia, proteus, morganella, providencia, cedecea, and hafnia spp. the delayed catalase reactors were escherichia, shigella, klebsiella, enterobacter, salmonella, citrobacter, edwardsiella, kluyvera, and tatumella spp. this info ...19873818934
the typing of morganella morgani by bacteriocin production and sensitivity.a typing scheme for morganella morgani based on bacteriocin (morganocin) production and sensitivity is described. these characteristics were determined by testing 160 strains in all combinations and permitted their differentiation into 90 types. morganocin production was induced with mitomycin c and morganocin sensitivity determined with a diluted inoculum on lab-lemco agar at 30 degrees c. most strains (82.5%) produced morganocins and 49 different types were defined. most strains (97.5%) were s ...19873820269
preliminary antimicrobial susceptibility interpretive criteria for cefetamet (ro 15-8074) and cefteram (ro 19-5247) disk tests.preliminary interpretive zone criteria were calculated for cefetamet (ro 15-8074) and cefteram (ro 19-5247) by using 10- and 30-micrograms disks and three possible mic susceptibility breakpoints. absolute interpretive agreement between mics and zone size criteria ranged from 91.8 to 97.2%. very major errors (false susceptibility) were less than or equal to 1.2% for both cephalosporin disk tests. morganella morganii strains appeared to produce the highest rates of very major interpretive errors w ...19873654953
in vitro activity of a new broad spectrum, beta-lactamase-stable oral cephalosporin, cefixime.cefixime is a new orally absorbed iminomethoxy, aminothiazolyl cephalosporin. it inhibits the majority, 90%, of streptococcus pneumoniae, streptococcus pyogenes, branhamella catarrhalis, haemophilus influenzae, escherichia coli, klebsiella pneumoniae, proteus mirabilis and neisseria gonorrhoeae at concentrations less than or equal to 0.25 micrograms/ml. it inhibits 90% of the other members of the enterobacteriaceae at concentrations less than 1 microgram/ml, with the exception of some strains of ...19873696836
the secreted hemolysins of proteus mirabilis, proteus vulgaris, and morganella morganii are genetically related to each other and to the alpha-hemolysin of escherichia coli.secreted hemolysins were extremely common among clinical isolates of proteus mirabilis, proteus vulgaris, and morganella morganii, and hemolytic activity was either cell associated or cell free. southern hybridization of total dna from hemolytic isolates to cloned regions of the escherichia coli alpha-hemolysin (hly) determinant showed clear but incomplete homology between genes encoding production of hemolysins in the four species. one of the two e. coli secretion genes, hlyd, hybridized only w ...19873549692
differences in antimicrobial susceptibilities of clinical isolates in saudi arabia and the united vitro antimicrobial susceptibilities of 3,530 clinical isolates at king faisal specialist hospital and research center (kfsh), in riyadh, saudi arabia, were compared with those of 11,041 bacterial isolates at two hospitals of comparable size in the united states. the gram-negative bacteria, especially escherichia coli, proteus-morganella group, enterobacter sp, serratia marcescens, and pseudomonas aeruginosa were generally more resistant to ampicillin, carbenicillin, cephalosporin, gentamicin ...19873586042
successful joint arthroplasty following proteus morganii (morganella morganii) septic arthritis: a four-year study.proteus morganii (morganella morganii) is an uncommon cause of septic arthritis. we describe a 53-year-old woman with severely deforming rheumatoid arthritis, who developed an indolent septic arthritis secondary to infection with this organism. she was treated with antibiotics and closed drainage, and subsequently, underwent successful arthroplasty. she continues to do well 4.5 years later. this patient's disease course shows that gram-negative septic arthritis, effectively treated, does not pre ...19873593440
diversity of the phosphoenolpyruvate/glucose phosphotransferase system in the enterobacteriaceae.the presence of the phosphoenolpyruvate glucose phosphotransferase entry routes was studied in 97 genospecies of enterobacteriaceae. phosphoenolpyruvate(pep)-dependent phosphorylation of alpha-methyl-d-glucoside and 2-deoxyglucose was evidenced in 72 species (group i organisms), suggesting the presence of both the iiglc (formerly ii-bglc/iiiglc) and iiman (formerly ii-b/ii-aman) entry routes. erwinia amylovora, budvicia aquatica and all species of leminorella and proteus (as defined by dna relat ...19873606872
genetic and biochemical diversity of ureases of proteus, providencia, and morganella species isolated from urinary tract infection.bacterial urease, particularly from proteus mirabilis, has been implicated as a contributing factor in the formation of urinary and kidney stones, obstruction of urinary catheters, and pyelonephritis. weekly urine specimens (n = 1,135) from 32 patients, residing at two chronic-care facilities, with urinary catheters in place for greater than or equal to 30 days yielded 5,088 phenotypically and serotypically diverse bacterial isolates at greater than or equal to 10(5) cfu/ml. a total of 86% of sp ...19873623698
comparative antibacterial activity of a new oral cephalosporin, bmy-28100.bmy-28100 is a new oral cephalosporin which had in vitro activity superior to that of cephalexin and cefaclor against staphylococci, beta-hemolytic streptococcal species, and streptococcus pneumoniae. it inhibited beta-lactamase-producing haemophilus influenzae, neisseria gonorrhoeae, 50% of streptococcus faecalis isolates, listeria monocytogenes, and 50 to 75% of escherichia coli and klebsiella species at less than or equal to 8 micrograms/ml, but high producers of beta-lactamase were resistant ...19873495236
in vitro activity and beta-lactamase stability of a new penem, cgp 31608.the in vitro activity of cgp 31608, a new penem, against aerobic and anaerobic organisms was evaluated and compared with those of other beta-lactams. cgp 31608 inhibited escherichia coli, klebsiella pneumoniae, k. oxytoca, proteus mirabilis, citrobacter diversus, and salmonella, shigella, aeromonas, and yersinia spp. with mics for 50% of the strains (mic50s) of 2 to 4 micrograms/ml and mic90s of 4 micrograms/ml, compared with cefotaxime, ceftazidime, aztreonam, and imipenem mics of less than 0.2 ...19873496845
comparative activity of ceftizoxime against aminoglycoside-resistant aerobic gram-negative bacilli.the in vitro activity of ceftizoxime was compared with that of other beta-lactam antibiotics against 331 aminoglycoside (ag)-resistant clinical isolates. two hundred and six ag-resistant, beta-lactamase producing, r-plasmid harbouring enterobacteriaceae strains had mics ranging from 0.0125 to 0.063 mg/l. ag-resistant escherichia coli (36 strains) and klebsiella pneumoniae (19) had mic 90 values of 8 mg/l. proteus rettgeri and p. vulgaris as well as morganella morganii, resistant to several ags, ...19873497792
in vitro activity of cefixime and six other agents against nosocomial pathogens of the enterobacteriaceae family.cefixime, a broad-spectrum, orally active cephalosporin, was more active in vitro than ampicillin, cefaclor, cephalothin, and trimethoprim/sulfamethoxazole against 194 nosocomial pathogens of the family enterobacteriaceae. activity was especially good against klebsiella spp, proteus spp, serratia spp, and providencia stuartii. although gentamicin had equivalent or better activity against citrobacter spp, enterobacter spp, escherichia coli, and morganella morganii, all 23 of the gentamicin-resist ...19873498702
successful treatment of morganella morganii meningitis with pefloxacin mesylate. 19873480886
identification of two different hemolysin determinants in uropathogenic proteus isolates.dna sequences similar to those of the escherichia coli hemolysin genes were detected among uropathogenic isolates of proteus vulgaris and morganella morganii by using the southern blotting technique and hly gene-specific dna probe. immunoblotting revealed that among the hemolytic p. vulgaris and m. morganii isolates there was expressed a polypeptide species similar in molecular size (110 kilodaltons) and antigenicity to escherichia coli hlya. a plasmid-mediated p. vulgaris hemolysin determinant ...19873305367
in vitro and in vivo antibacterial activities of cs-807, a new oral cephalosporin.cs-807 is a new oral prodrug of r-3746, a cephalosporin derivative, with potent in vitro and in vivo antibacterial activity against both gram-positive and gram-negative bacteria. the susceptibility of about 1,200 clinical isolates to r-3746 was determined by the agar dilution method. ninety percent or more of pathogens such as staphylococcus aureus, streptococci, escherichia coli, klebsiella pneumoniae, klebsiella oxytoca, indole-positive and indole-negative proteus spp., providencia rettgeri, a ...19873310868
clinical significance of beta-lactamase induction and stable derepression in gram-negative rods.most strains of enterobacteria and pseudomonas aeruginosa produce chromosomally-determined class i beta-lactamases. when synthesized copiously these enzymes cause resistance to almost all beta-lactams, except imipenem and, sometimes, carbenicillin and tenocillin. elevated beta-lactamase production arises transiently, via induction, in pseudomonas aeruginosa and enterobacter, citrobacter, morganella, indole-positive proteus and serratia spp. when these organisms are exposed to beta-lactams. perma ...19873311738
identification of porins in outer membrane of proteus, morganella, and providencia spp. and their role in outer membrane permeation of beta-lactams.proteus mirabilis, proteus vulgaris, morganella morganii, providencia rettgeri, and providencia alcalifaciens, which were once classified into the same genus, proteus, were studied. cefoxitin-resistant mutants from these species were isolated, and it was confirmed that the resistance was attributed to the lack of an outer membrane protein, resulting in a significant decrease in the penetration of hydrophilic cephalosporins through the outer membrane. comparison of the mutant strains with their p ...19873034144
urease activity of proteus penneri.ten strains of proteus penneri isolated from geographically diverse laboratories were tested for urease activity. cell lysates from urea-induced cells had a mean activity of 4.9 +/- 4.1 mumol of nh3 per min per mg of protein. on nondenaturing 6% polyacrylamide activity gels, the enzymes of p. penneri had very similar electrophoretic mobilities within species and within the proteus genus but were distinct from the ureases of providencia and morganella species. on lower-percentage polyacrylamide, ...19873429622
comparative in vitro activities of 13 antimicrobial agents against morganella-proteus-providencia group bacteria from urinary tract infections.we examined 741 urinary tract isolates of the morganella-proteus-providencia group, including the recently defined species proteus penneri, for susceptibilities to aminoglycosides, semisynthetic penicillins, and cephalosporins. the data emphasize the importance of identification to the species level on the basis of marked species differences in patterns of susceptibility.19873435110
comparative in vitro activity of the two new oral cephalosporin metabolites ro 19-5247 and ro 15-8074.a total of 629 clinical strains of gram positive and gram negative bacteria were tested for their susceptibility to ro 19-5247, ro 15-8074, and other antimicrobial agents. both ro 19-5247 and ro 15-8074 had good activity against strains of enterobacteriaceae; however, resistance was found among some strains of enterobacter, citrobacter, klebsiella and morganella spp. both compounds showed moderate to poor active against acinetobacter spp., pseudomonas aeruginosa, staphylococci and streptococcus ...19873436316
numerical analysis of electrophoretic protein patterns of providencia rustigianii strains from human diarrhoea and other sources.twenty strains of providencia rustigianii (including the type strain of prov. friedericiana) have been characterized by one-dimensional sds-page of cellular proteins. they comprised 12 strains (almost exclusively associated with the intestinal tract) from humans, plus eight largely from the intestinal tract of pig, penguin and environmental sources. the protein patterns, which contained 45-50 discrete bands, were highly reproducible and were used as the basis for two numerical analyses. in the f ...19873436856
urease-positive bacteriuria and obstruction of long-term urinary catheters.long-term urethral catheterization (greater than or equal to 30 days), a management technique for urinary incontinence, results in polymicrobial bacteriuria. we frequently found urease-producing bacteria: of 1,135 weekly urine specimens from 32 long-term-catheterized patients, 86% had urease-positive bacterial species at greater than or equal to 10(5) cfu/ml. the most common species were proteus mirabilis and morganella morganii, each found in over half the specimens. p. mirabilis, but not other ...19873320089
microbiological perspectives of co-trimoxazole.trimethoprim-sulfamethoxazole in vitro activity was compared with ampicillin, tetracycline, sulfonamide and trimethoprim against isolates of 24 gram-negative and 11 gram-positive species. the incidence of more than 10% of strains with minimal inhibitory concentrations above 32 mg/l was restricted to escherichia coli, shigella spp., klebsiella pneumoniae, providencia rettgeri, morganella morganii, methicillin-resistant staphylococcus aureus and staphylococcus epidermidis. occasionally, streptococ ...19873325434
[the antimicrobial activity of sisomicin against fresh clinical isolates].antimicrobial activities of sisomicin (siso) against clinical isolates obtained in the second half of 1986 were investigated together with other 4 aminoglycosides (ags) (gentamicin (gm), tobramycin (tob), dibekacin (dkb), amikacin (amk] and 2 cephems (cefotiam, cefotaxime), and were compared to the results reported in the period of late 1970's through early 1980's in japan. 1. the incidence of siso-resistant staphylococcus aureus in the present study was 18% and is comparable to that of the othe ...19873327965
induction of the beta-lactamases of a strain of pseudomonas aeruginosa, morganella morganii and enterobacter cloacae. 19873106306
purification and properties of pyridoxal-5'-phosphate-dependent histidine decarboxylases from klebsiella planticola and enterobacter aerogenes.histidine decarboxylases from klebsiella planticola and enterobacter aerogenes were purified to homogeneity and compared with the histidine decarboxylase from morganella morganii. all three enzymes required pyridoxal 5'-phosphate as a coenzyme, showed optimal activity at ph 6.5, decarboxylated only histidine among the amino acids derived from protein, and were tetramers or dimers of identical subunits. amino-terminal sequences of the three enzymes showed up to 81% homology through residue 33, bu ...19873114230
incidence of inducible beta-lactamases in gram-negative septicemia isolates from twenty-nine european laboratories. european study group on antibiotic 1984 the european study group on antibiotic resistance (esgar), which is made up of 29 laboratories in 12 european countries, consecutively collected gram-negative bacilli and staphylococci isolates from blood and using the microdilution method performed susceptibility testing with 11 beta-lactam antibiotics. a total of 2,578 isolates were collected; 68% were gram-negatives and 32% staphylococci. pseudomonas spp. accounted for 12% of the strains, enterobacter spp. 7%, serratia spp. 3%, indole ...19873117535
in vitro activity of desacetylcefotaxime and the interaction with its parent compound, cefotaxime.antibacterial activities of cefotaxime and its major metabolite, desacetylcefotaxime, against 178 strains (of 10 species) were assessed in terms of minimum inhibitory concentrations (mic50 and mic80), and were compared with those of cefoperazone and ceftazidime. the activity of desacetylcefotaxime was several times less than that of cefotaxime against almost all of the species tested. against staphylococcus aureus, morganella morganii, enterobacter cloacae and pseudomonas aeruginosa, the mic80 v ...19883135170
mechanism of inhibition of chromosomal beta-lactamases by third-generation cephalosporins.the kinetic interactions of the beta-lactamase from enterobacter cloacae 908 r with ceftriaxone, cefotaxime, and ceftazidime have been examined in detail. with all of these cephalosporins, there is an initial rapid reaction involving opening of the beta-lactam that then decreases to a slower steady-state rate (kss) of beta-lactam hydrolysis (at 37 degrees c: ceftriaxone, kss = 0.044 s-1; cefotaxime, kss = 0.033 s-1; ceftazidime, kss = 0.011 s-1). more than stoichiometric quantities of beta-lacta ...19883142012
in vitro activity of e-1040, a novel cephalosporin with potent activity against pseudomonas aeruginosa.the in vitro activity of e-1040 [(6r,7r)-3-[(4-carbamoyl-1-quinuclidinio)methyl]-7-[2-(5-amino-1,2 ,4- thiadiazol-3-yl)-(z)-2-methoxyiminoacetoamido]-8-oxo-5-thia- 1- azabicyclo(4,2,0)oct-2-ene-2-carboxylate], a novel cephalosporin, was compared with that of ceftazidime, cefpirome, cefepime, imipenem, and gentamicin. e-1040 inhibited 50% of members of the family enterobacteriaceae, pseudomonas aeruginosa, and haemophilus and neisseria species at less than or equal to 0.25 microgram/ml, and the m ...19883150915
[the hemolytic properties of strains of morganella morganii]. 19882967119
further differentiation of enterobacteriaceae by means of siderophore-pattern means of a combination of 5 siderophore bioassays using several indicator strains, genera, species and subspecies of enterobacteriaceae can be further differentiated. enterobactin, aerobactin and other siderophores produced can be detected. each strain shows specific pattern which we called siderophore-pattern. it is easy to separate morganella, proteus, providencia, yersinia strains from the genera salmonella, shigella, escherichia coli, enterobacter, citrobacter, klebsiella, serratia. enter ...19882970195
[susceptibilities of clinical isolates to antibacterial agents. focusing mainly on ofloxacin (first report). reported by the research group for testing ofloxacin susceptibility of clinical isolates].susceptibility tests were carried out on a variety of clinically isolated pathogens using the susceptibility disc method at 197 hospitals in japan between may, 1985 through march, 1986. these tests were organized by the research group for testing ofloxacin susceptibility on clinical isolates, and the results were statistically analyzed. this paper describes a comparison of susceptibilities of clinical isolates including staphylococcus aureus, staphylococcus epidermidis, enterococcus faecalis, st ...19883163383
in vitro activity of lomefloxacin (sc-47111; ny-198), a difluoroquinolone 3-carboxylic acid, compared with those of other quinolones.lomefloxacin (sc-47111; ny-198) is a new difluoroquinolone agent. it inhibited 90% of escherichia coli, klebsiella spp., enterobacter spp., citrobacter spp., proteus mirabilis, morganella morganii, proteus vulgaris, serratia marcescens, salmonella spp., shigella spp., aeromonas spp., yersinia spp., haemophilus influenzae, and neisseria gonorrhoeae at less than or equal to 2 micrograms/ml. lomefloxacin inhibited 90% of pseudomonas aeruginosa at 4 micrograms/ml. lomefloxacin was equal in activity ...19883164987
properties and participation of "free" endotoxin in the toxic activity of morganella morganii."free" and "bound" morganella morganii endotoxin was characterized by chemical (determination of proteins, saccharides and 3-deoxy-2-octulosonic acid) and immunochemical (double-diffusion test, immunoelectrophoresis, tandem crossed immunoelectrophoresis) methods. chemical analysis showed that "free" endotoxin contains more protein and phosphorus and less saccharides than bound endotoxin. immunochemical tests revealed differences in the structure of polysaccharide portions of both endotoxins, and ...19883181832
isotope effect studies of the pyridoxal 5'-phosphate dependent histidine decarboxylase from morganella morganii.the pyridoxal 5'-phosphate dependent histidine decarboxylase from morganella morganii shows a nitrogen isotope effect k14/k15 = 0.9770 +/- 0.0021, a carbon isotope effect k12/k13 = 1.0308 +/- 0.0006, and a carbon isotope effect for l-[alpha-2h]histidine of 1.0333 +/- 0.0001 at ph 6.3, 37 degrees c. these results indicate that the overall decarboxylation rate is limited jointly by the rate of schiff base interchange and by the rate of decarboxylation. although the observed isotope effects are qui ...19883191100
association of reactive arthropathy and morganella morganii cross reacting with yersinia enterocolitica.two patients exhibited reactive arthropathy in association with chronic diarrhoea and abdominal pain. rising titres of agglutinating antibody to yersinia enterocolitica o3 were observed in association with arthropathy. morganella morganii was isolated from faeces of one patient in heavy growth. in both patients, absorption of the sera with morganella antigen abolished yersinia reactivity. morganella titres were more than 8 times the yersinia titres and were unaffected by absorption with yersinia ...19883194711
[evaluation on the capability of indole pyruvic acid production by members of proteeae on different brands of sulfide-indole-motility].members of proteeae were vertically inoculated into different brands of sulfide-indole-motility (sim) medium for evaluating the capability of ipa production. a total of 328 clinical strains of tribe proteeae was used as tested organisms, including 186 proteus mirabilis strains, 62 morganella morganii strains, 31 proteus vulgaris strains, 27 providencia rettgeri strains, 14 providencia stuartii and 8 providencia alcalifaciens strains. seven different brands of sim medium used in this study are ky ...19883197461
in vitro activities of a-56619 (difloxacin) and a-56620, two aryl fluoroquinolones.the in vitro activities of a56619 (difloxacin) and a-56620, two newer quinolones, have been compared with the activities of ciprofloxacin, ofloxacin, ceftazidime and netilmicin. a total of 782 clinical, bacterial isolates were employed. minimal inhibitory concentrations (mics) were determined under standard conditions with all isolates and, for 100 isolates against difloxacin and a-56620, with variation of agar ph and bacterial inoculum size. on a weight-for-weight basis, ciprofloxacin and a-566 ...19883208547
[antibacterial activities of monobactams against fresh clinical isolates].antibacterial activities of monobactam antibiotics (carumonam (crmn) and aztreonam (azt] against gram-negative bacilli isolated from inpatients in the latter half of 1987 were investigated using penicillin (pc: piperacillin (pipc], cephems (ceps: ceftazidime (caz), cefotaxime (ctx), latamoxef (lmox), cefsulodin (cfs], carbapenem (imipenem (ipm] and pyridonecarboxylic acids (norfloxacin (nflx) and ofloxacin (oflx] as reference antibiotics. a total of 400 strains of 13 species, i.e. escherichia co ...19883210297
[antibacterial activity of gentamicin against clinical isolates in pediatrics].antibacterial activity of gentamicin (gm), along with activities of other aminoglycosides and beta-lactams, was studied against clinical isolates collected from pediatric patients during a period of may 1986-april 1987. 1. gm-resistance was noted in 22% of staphylococcus aureus, 6% of proteus vulgaris, 8% of morganella morganii, 40% of providencia spp., 6% of enterobacter spp., 14% of serratia marcescens, and 14% of pseudomonas aeruginosa isolates. no gm-resistance was observed with isolates of ...19883216475
[bacteriocinogenic properties of morganella morganii]. 19883216764
[the in vitro activity of ofloxacin, pefloxacin and ciprofloxacin against various gram negative bacteria isolated from urinary tract infections].in this study the in vitro activity of ofloxacin, pefloxacin and ciprofloxacin against various gram negative bacteria isolated from urinary tract infections was examined. of 80 isolates (24 e. coli, 10 enterobacter, 10 klebsiella, 23 proteus, 10 pseudomonas, 2 morganella and 1 serratia) 49 were from inpatients, and 31 were from outpatients. ciprofloxacin was the most potent compound and no resistant strain was found against ciprofloxacin, while 1 enterobacter strain and 1 pseudomonas strain were ...19883252111
in vitro activity of an oral iminomethoxy aminothiazolyl cephalosporin, r-3746.the in vitro activity of r-3746, an iminomethoxy aminothiazolyl cephalosporin with a ch2och3 moiety at position 3, was compared with those of other antibiotics. r-3746 inhibited the majority of hemolytic streptococci (groups a, b, c, f, and g) and streptococcus pneumoniae at less than 0.06 micrograms/ml, which was comparable to the activity of amoxicillin, 2- to 8-fold more active than cefixime, and 16- to 64-fold more active than cefaclor and cephalexin. ninety percent of beta-lactamase-produci ...19883260766
activity of temocillin and other penicillins against beta-lactamase-inducible and -stably derepressed enterobacteria.mics of temocillin, carbenicillin, ticarcillin, mezlocillin, piperacillin and ampicillin were determined for mutant series of enterobacter cloacae, citrobacter freundii, proteus vulgaris, morganella morganii and serratia marcescens with inducible, stably derepressed or basal expression of chromosomal class i beta-lactamases. ampicillin was inactive (mic greater than 256 mg/l) both against beta-lactamase-inducible organisms (except c. freundii) and their stably derepressed mutants, whereas basal ...19883263354
production and properties of haemolysins from clinical isolates of the proteeae.a collection of 198 clinical isolates of strains belonging to the tribe proteeae was examined for haemolytic activity on blood agar and in brain heart infusion broth. the strains were of diverse bacteriocin and o-antigenic types and from a wide variety of sources. they included representatives of all species of morganella, proteus and providencia. approximately half of the m. morgani strains were haemolytic on blood agar. this activity was not associated with any particular bacteriocin type. the ...19883275780
a survey of iga protease production among clinical isolates of proteeae.a collection of 100 strains of proteeae, in which all species within the tribe were represented, was examined for iga protease production. the strains were isolated from various clinical specimens from sick and healthy persons in several countries. iga protease-producing strains were not found amongst species of providencia and morganella but were common in proteus spp. all the strains of p. mirabilis and p. penneri and many of the strains of p. vulgaris examined produced an edta-sensitive prote ...19883275781
rapidec ur, a 2-h miniaturized system for pinpointing uropathogens.a miniaturized 2-h system (rapidec ur; api system, la balme-les-grottes, montalieu-vercieu, france) that uses nine enzymatic tests for the diagnosis of most uropathogens was challenged with 330 strains. with few exceptions (citrobacter, enterobacter, and providencia spp., morganella morganii, and staphylococci other than staphylococcus saprophyticus), there were distinct patterns that allowed at least a preliminary species diagnosis.19883277991
tigemonam, an oral monobactam.tigemonam is an orally administered monobactam. at less than or equal to 1 microgram/ml it inhibited the majority of strains of escherichia coli, klebsiella spp., enterobacter aerogenes, citrobacter diversus, proteus spp., providencia spp., aeromonas hydrophila, salmonella spp., shigella spp., serratia marcescens, and yersinia enterocolitica. at less than or equal to 0.25 microgram/ml it inhibited haemophilus spp., neisseria spp., and branhamella catarrhalis. it did not inhibit pseudomonas spp. ...19883279906
evaluation of the ids rapid ss/u system for rapid identification of urinary microorganisms.the accuracy of a new rapid identification system for common urinary pathogens was compared with that of conventional methods and of miniaturized 18-24-hour identification panels. the rapid system, rapid ss/u (innovative diagnostic system inc., atlanta, ga) is a non-growth-dependent micro-method that identifies selected gram-negative bacilli, gram-positive cocci, and yeasts in two hours by detection of constitutive enzymes acting on chromogenic substrates. a total of 185 representative clinical ...19883285661
bacteremia and septic arthritis in a west african dwarf anorectic, adult west african dwarf crocodile was examined because of bilateral hind limb paresis. clinical findings included multiple skin wounds, osteomyelitis of the distal portions of the right radius and ulna, severe anemia, and serratia marcescens bacteremia. the crocodile died after a blood transfusion. at necropsy, hemorrhage in the subarachnoid space, suppurative polyarthritis, and gastric ulceration were found. serratia marcescens and morganella morganii were isolated from multiple ...19883292493
comparative in vitro activity of amoxycillin/clavulanate (augmentin), ceftazidime and ceftriaxone against hospital strains of gram-negative and -positive bacteria.the in vitro antibacterial activities of amoxycillin/clavulanate (augmentin), ceftazidime and ceftriaxone were compared against 330 gram-negative and gram-positive strains isolated from clinical specimens received at the king abdulaziz university hospital (kauh) in saudi arabia. the antibacterial susceptibility was determinated by stokes method and by the minimal inhibitory concentration (mic) using an agar dilution method. ceftazidime and ceftriaxone were the most active antibiotics, inhibiting ...19883293818
a survey of clinical experience with ciprofloxacin, a new quinolone antimicrobial.ciprofloxacin is a new quinolone antimicrobial agent with activity against a broad spectrum of gram-negative and gram-positive organisms, including pseudomonas aeruginosa and methicillin-resistant strains of staphylococci. the efficacy and safety results of 80 clinical studies of the oral form of ciprofloxacin are reported. drug safety was assessed in 2236 courses in 2203 adult patients treated primarily in the united states. data from 1676 courses were suitable for analysis of drug efficacy. th ...19883360968
predictors of endocarditis in isolates from cultures of blood following dental extractions in rats with periodontal disease.rats with periodontitis and catheter-induced aortic valve vegetations underwent dental extractions. cultures of blood obtained 1 min later showed polymicrobial bacteremia in 19 of 19 rats, mostly due to viridans streptococci (18 of 19), morganella (15 of 19), group g streptococci (13 of 19), and staphylococcus aureus (10 of 19). viridans streptococci circulated in higher numbers than did group g streptococci and s. aureus (p less than .01). three days after dental extractions, 18 of 20 rats had ...19883361156
a survey of the aerobic bacteria in the feces of captive raptors.feces of 47 captive raptors belonging to the order falconiformes or strigiformes were cultured for bacteria. gram-negative bacteria, which were cultured from the feces of 45 of the 47 raptors, were the most common isolates. a wide variety of species were identified, including a newly described genus (moellerella wisconsensis), two newly described species (escherichia fergusonii and proteus penneri), and a member of a newly described enteric group (cdc enteric group 41). additional organisms iden ...19883382380
the phylogenetic origin of the bifunctional tyrosine-pathway protein in the enteric lineage of bacteria.because bifunctional enzymes are distinctive and highly conserved products of relatively infrequent gene-fusion events, they are particularly useful markers to identify clusters of organisms at different hierarchical levels of a phylogenetic tree. within the subdivision of gram-negative bacteria known as superfamily b, there are two distinctive types of tyrosine-pathway dehydrogenases: (1) a broad-specificity dehydrogenase (recently termed cyclohexadienyl dehydrogenase [cdh]) that can utilize ei ...19883386529
cefotaxime combined with selective decontamination in long term intensive care unit patients. virtual absence of emergence of resistance.emergence of bacterial resistance to antimicrobial agents was studied during a period of 30 months of continuous use of parenteral cefotaxime combined with oral non-absorbable polymyxin e and tobramycin (selective decontamination) in a surgical intensive care unit (icu). no increase in drug-resistance micro-organisms was found. colonisation of the oropharyngeal cavity or intestine or both by strains resistant to polymyxin e occurred in 8% of patients (invariably proteus and morganella species). ...19883396487
chronic morganella morganii arthritis in an elderly patient.this report describes the first case of septic arthritis caused by morganella morganii. the elderly patient's course of pyoarthritis was atypical in its benign clinical presentation, having little inflammatory response over a prolonged period. septic arthritis should be considered as a possible diagnosis in all elderly patients with joint effusions.19883410954
immunization with rough mutants of salmonella minnesota: protective activity of igm and igg antibody to the r595 (re chemotype) mutant.we evaluated the immunoglobulin class responsible for the protective activity in serum obtained from humans and rabbits after immunization with the r595 (re chemotype) mutant of salmonella minnesota. whole serum obtained before immunization and the igg and igm fractions failed to protect mice against lethal challenge with viable klebsiella pneumoniae or morganella morganii or with salmonella typhi lipopolysaccharide (lps). the protective activity of postimmunization serum resided solely in igm a ...19883042871
comparison of the haemolysin secretion protein hlyb from proteus vulgaris and escherichia coli; site-directed mutagenesis causing impairment of export function.the hlyb secretion genes of proteus vulgaris and escherichia coli showed 81% nucleotide homology and similar e. coli-atypical codon usage. the deduced protein sequences differed in 54 of 707 residues and shared a previously unreported sequence which corresponds to the atp-binding motif characteristic of protein kinases. the motif was also conserved in the hlyb of morganella morganii. of 4 oligonucleotide-directed substitutions introduced into the putative e. coli hlyb motif, 2 non-conservative c ...19883054490
chromosomal beta-lactamase expression and resistance to beta-lactam antibiotics in proteus vulgaris and morganella morganii.indole-positive members of the proteeae usually have inducible expression of chromosomal beta-lactamases. mutants with stably derepressed beta-lactamase expression occur in inducible populations at frequencies in the range of 10(-6) to 10(-8). the contribution of these beta-lactamases to drug resistance was examined in morganella morganii and proteus vulgaris. the m. morganii enzyme was a high-molecular-weight (49,000) class i cephalosporinase with low vmax rates for ampicillin, carbenicillin, a ...19883058021
[lysogeny in strains of proteus mirabilis and morganella morganii]. 19883060268
bacterial lysis of fibrin seal in vitro.we performed an in vitro study to determine whether certain bacteria may lyse a commercially available fibrin seal (beriplast, behringwerke, marburg, frg). fibrinogen solution was mixed with actively growing bacterial cultures, and thrombin was added. during 20 days of incubation at 37 degrees c complete lysis was observed with a number of different bacteria, however, at different rates. complete lysis within 1-5 days was observed for the following species (number of strains in parentheses): str ...19882456934
haemolytic activity of morganella morganii strains.haemolytic activity on solid and liquid media of 103 morganella morganii strains isolated from clinical sources was investigated. the ability to produce haemolysin was found in 42.7% of strains. all strains capable to produce haemolysin on blood agar media also revealed haemolytic activity in some liquid media. haemolysins were found in the supernatants and filtrates of the cultures in peptone water but not in brain heart infusion and trypticase soy broth. the maximal titer of haemolysin was obs ...19882462333
[evaluation of sen-sir, a new microsystem for the identification and determination of bacterial sensitivity].the use of semiautomatic methods for identification and study of bacterial sensitivity to antimicrobials is increasingly widespread in clinical microbiology. in the present study, the evaluation of a new micromethod (sen-sir, bbl) for the identification and determination of bacterial sensitivity is reported. 115 clinical isolates of enterobacteria, 10 strains of acinetobacter calcoaceticus and 57 gram positive cocci, previously identified as belonging to the geni staphylococcus and streptococcus ...19892490681
[urease activity of bacteria in urine].urea splitting bacteria are related to the formation of struvite or apatite. we investigated the urease activity of bacteria by two methods; the direct measurement of urease activity of viable bacteria and sonicated bacteria from amounts of ammonia by the indophenol method, and the measurement of urease activity by alkalization of infected urine. proteus mirabilis and pseudomonas aeruginosa had moderate activity of urease, and morganella morganii and staphylococcus epidermidis had the most power ...19892500012
[investigations on the etiology of sepsis by using an experimental mouse model with leukocytopenia. 2. the role of the reticuloendothelial system in the etiology of bacteremia].it has been recognized by clinical data that most of sepsis occurring in the immunocompromised host are endogenous infection. in recent years, we have investigated the mechanism of these bacteremia and sepsis by experimental studies using neutropenic mice treated with cyclophosphamide. and we evidenced that most pathogens causing bacteremia originated in the intestinal flora of the host. it has been shown that bacteria causing bacteremia were divided into two main groups, causing systemic bacter ...19892507683
comparative in vitro activity of sm7338, a new carbapenem antimicrobial agent.the comparative in vitro activity of sm7338 was tested against 670 routine clinical isolates and 130 cefoperazone-resistant isolates of bacteria by agar dilution methods. sm7338 was at least as active as imipenem against gram-negative organisms but was slightly less active against gram-positive organisms. sm7338 was particularly active against members of the family enterobacteriaceae, with mics for 90% of strains of less than or equal to 0.125 micrograms/ml for all species tested. differences in ...19892508543
the postantibiotic effect of meropenem and imipenem on selected bacteria.controlled experiments were conducted to determine the in-vitro postantibiotic effect (pae) of meropenem and imipenem on ten selected bacteria representative of medically important species: staphylococcus aureus (2). pseudomonas aeruginosa (4), escherichia coli (1), serratia marcescens (1), morganella morganii (1), and providencia stuartii (1). the pae was determined by comparing serial colony counts of cultures recovering from exposure to drug concentrations at 4 x mic for 1.5 h with the counts ...19892509416
in-vitro activity of meropenem imipenem, the penem hre 664 and ceftazidine against clinical isolates from west germany.the antibacterial activity in vitro of meropenem was compared with another carbapenem, imipenem, the penem hre 664, and ceftazidime. mics were not influenced by ph nor by inoculum size below 5 x 10(5) cfu/ml: higher inocula caused a modest increase in mic. cation supplementation of mueller-hinton broth was without effect. meropenem was more active than imipenem and the other comparative agents against the majority of gram-negative species (in particular proteus, providencia, morganella, haemophi ...19892509418
in vitro and in vivo efficacy of ytr-830h and piperacillin combinations versus beta-lactamase-producing bacteria.ytr-830h, a beta-lactamase inhibitor, is a non-amino penicillanic sulfone. in vitro synergistic activity with piperacillin was determined for 226 beta-lactamase producing clinical cultures. combination of piperacillin: ytr in ratios of 2:1, 4:1, and 8:1 were highly effective vs escherichia coli, proteus, providencia, morganella, staphylococcus, and bacteroides. minimum inhibitory concentrations (mics) of piperacillin were reduced from the resistant to susceptible range. the higher ratios were le ...19892552030
comparative in vitro activities of piperacillin-tazobactam and ticarcillin-clavulanate.the in vitro activities of ticarcillin, piperacillin, clavulanic acid, tazobactam, ticarcillin-clavulanate, and piperacillin-tazobactam against 819 bacterial isolates were compared. the two beta-lactamase inhibitors, clavulanic acid and tazobactam, had little useful antibacterial activity but enhanced the activities of the penicillins against beta-lactamase-producing strains of haemophilus influenzae, branhamella catarrhalis, and methicillin-susceptible staphylococcus aureus; all strains were su ...19892552904
comparative in vitro and in vivo activities of piperacillin combined with the beta-lactamase inhibitors tazobactam, clavulanic acid, and sulbactam.tazobactam (ytr-830h), a novel beta-lactamase inhibitor, was compared with clavulanic acid and sulbactam for enhancement of the activity of piperacillin against beta-lactamase-producing, piperacillin-resistant clinical isolates. piperacillin mics were determined in media containing a fixed concentration of 2 or 4 micrograms of the inhibitors per ml. the higher concentration was generally more effective. tazobactam was superior to sulbactam in enhancing the spectrum and potency of piperacillin. a ...19892558615
studies to optimize the in vitro testing of piperacillin combined with tazobactam (ytr 830).the combination of piperacillin and the beta-lactamase inhibitor tazobactam (formerly ytr 830) was studied to determine optimal disk concentrations and dilution testing conditions. in addition, the potency of the combination was compared to that of piperacillin alone. the spectrum of piperacillin was greatly expanded by the addition to tazobactam principally against beta-lactamase producing strains of haemophilus influenzae, escherichia coli, morganella morganii, proteus vulgaris, providencia st ...19892560422
type 3 fimbriae among enterobacteria and the ability of spermidine to inhibit mr/k hemagglutination.the distribution of the gene cluster encoding type 3 fimbriae among various isolates of the family enterobacteriaceae was investigated by using 112 clinical and nonclinical isolates. closely related dna sequences were detected in all klebsiella strains, in most enterobacter isolates, in a smaller number of escherichia coli and salmonella spp., and in a single isolate each of yersinia enterocolitica and serratia liquefaciens but not in isolates of morganella or providencia species or serratia mar ...19892562835
ciprofloxacin in patients with bacteremic infections. the spanish group for the study of ciprofloxacin.the efficacy and safety of ciprofloxacin in the treatment of 68 episodes of bacteremia were studied. patients were treated intravenously (30 cases), orally (13 cases), or with sequential intravenous/oral therapy (25 cases). intravenous doses ranged from 200 to 400 mg per day and oral doses ranged from 1,000 to 1,500 mg per day. according to the criteria of mccabe and jackson, 39 cases had nonfatal and 29 had ultimately fatal underlying diseases. the clinical condition of patients at the start of ...19892589366
comparative in vitro activity and beta-lactamase stability of fk482, a new oral cephalosporin.fk482 is an oral aminothiazolyl hydroxyimino cephalosporin with a c-3 vinyl group. its activity was compared with those of cephalexin, cefuroxime, cefixime, and amoxicillin-clavulanate. fk482 inhibited 90% of staphylococcus aureus isolates at 1 micrograms/ml and 90% of streptococcus pyogenes, streptococcus agalactiae, and streptococcus pneumoniae isolates at less than or equal to 0.012 micrograms/ml, superior to cephalexin and cefuroxime and similar to cefixime. it did not inhibit oxacillin-resi ...19892589845
clavulanate and beta-lactamase induction.concern has been expressed that clavulanate can antagonize ticarcillin against enterobacteria and pseudomonads that have inducible expression of chromosomal 'class i' beta-lactamases. it is suggested that clavulanate-induced enzyme inactivates ticarcillin, which itself is a feeble inducer. we confirmed that this mechanism applied, showing that antagonism was abolished in beta-lactamase-basal mutants of inducible strains. antagonism has been reported in double disc tests with strains of pseudomon ...19892606817
[determination of the mic of cefotetan against freshly isolated gram-negative bacilli].antimicrobial activities (mics) of cefotetan (ctt) against 575 strains of 16 spp. of gram-negative bacilli isolated in 1988 were determined to investigate distribution of mics in comparison with those of cefmetazole (cmz), cefoxitin (cfx), latamoxef (lmox) and cefazolin (cez). the change in frequencies of incidence of cephem-resistant strains in the latter half of the 1980 was also investigated. distribution of mic of ctt varied with test strains. no or very few mics were at or higher than 12.5 ...19892621779
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