malignant transformation of a mouse epithelial cell line with polycyclic aromatic hydrocarbons. 197897564
response-dependent effects of morphine on reinforcing lateral hypothalamic self-stimulation.the effects of morphine (10mg/kg) on intracranial self-stimulation were studied in three separate test situations, each requiring rats to perform different types of responses. self-stimulation was depressed in a test of rate of bar-pressing, to a lesser extent in a test of rate of wall-pressing in which a wider range of movements were reinforced, but not in a shuttle-box, with brain stimulation continuously available on one side of box. this resonse dependency suggests that the depressive effect ...197897721
evaluation of spiramycin as a therapeutic agent for elimination of nasopharyngeal pathogens. possible use of spiramycin for middle ear infections and for gonococcal and meningococcal nasopharyngeal carriage.varying doses of spiramycin were administered orally to healthy volunteers, and concentrations in serum and saliva were determined. the absorption of the drug was not significantly influenced by concomitant food intake. saliva peak concentrations were 1.3--4.8 times higher than peak concentrations in serum. the elimination half life was 2--3 h in serum, and 4--8 h in saliva. accumulation of the drug was seen in saliva but not in serum. the possible effect of spiramycin in eliminating bacteria fr ...197897775
gentamicin-resistant gram-negative bacilli in hospital patients. part i. preliminary epidemiological assessment.gentamicin-resistant gram-negative bacilli (grnb) have been isolated from specimens received from 23 hospitals in and around johannesburg. most isolates are fermentative in nature. a pilot survey among inpatients at the johannesburg hospital revealed an intestinal carriage prevalence of 14,3%. a prospective study of intestinal acquisition showed that grnb are acquired in hospital, and that colonization is associated with prior antibacterial therapy. analysis of clinical specimens received from t ...197897791
[obtaining the capsular fraction of the causative agent of anthrax]. 197897851
[sarcocyst resistance to certain factors]. 197897852
the histochemistry of mucosubstances in ferret salivary glands.the mucosubstances of the major salivary glands of the ferret were analysed using different histochemical reactions. almost all the parotid acinar cells had sialic acid-containing mucus. there were a very few cells, the granules of which gave reactions for sulphated mucins. submandibular gland mucus was sulphated in the major parts of the gland. there were occasional cells which gave reactions to carboxylated mucin. the sublingual and the molar glands had tubules which had 2 types of mucous cell ...197897904
a sensory mechanism for amblyopia: electrophysiological studies.steady-state visual evoked potentials were elicited by the appearance/disappearance of sinusoidal gratings of varying spatial frequency for both eyes of amblyopic subjects at temporal frequences from 2--32 hz. the amblyopic eyes showed reduced responses relative to those of the nonamblyopic eyes across a wide range of spatial frequencies, the difference between the 2 eyes being most marked for high spatial frequencies and low temporal frequencies. both the nonamblyopic and the amblyopic eyes sho ...197898048
transient change in the atp pool of anabaena cylindrica associated with ammonia assimilation.when n2-grown cells of anabaena cylindrica were exposed to ammonia (50 micron to 5 mm) in the dark, the size of the atp pool was reduced by 40% within 1 min, but restored after 5 or 6 min. the decrease in atp was accompanied by increases in adp and amp, while the total adenylate content remained unaltered. the ammonia-induced change in the atp pool was completely eliminated when algal cells were treated with l-methionine-dl-sulfoximine, an inhibitor of glutamine synthesis. these results suggest ...197898124
the occurrence and identification of intracellular polyglucose storage granules in methylococcus ncib 11083 grown in chemostat culture on methane.the accumulation of intracellular storage granules (0.03--0.5 micrometer) by methylococcus ncib 11083 when grown under conditions of ammonia limitation with methane as the sole source of carbon and energy was inversely proportional to the dilution rate. the isolated material was composed entirely of glucose residues and the infra-red spectrum exhibited characteristic absorption bands at 925 cm(-1), 845 cm(-1) and 745 +/- 4cm(-1), indicating the presence of alpha (1 leads to 4) glycosidic linkage ...197898125
[alteration of the construction and cellular composition of ileo-colonic lymph nodes of rhesus macaques after administration of salmonella vaccine].in stained histological sections, percentage ratio of areas to different cellular elements in structural components of the ileocolonic lymph nodes was studied in mature macaca rhesus, normal and after injection of salmonella vaccine. a rather considerable reaction in all structural components and cell composition of the lymph nodes was demonstrated as a response to immunization of the animals. these changes were demonstrated in decreased area occupied by the cortical substance and in increased a ...197898134
extrageniculostriate vision in the monkey. vi. visually guided accurate reaching behavior. 197898218
biochemical changes in guinea pig lungs due to amosite asbestos. 197898326
immunological study of glutamate synthase and its subunits. 197898351
calcium-dependent binding of mouse epididymal spermatozoa to the zona pellucida. 197898372
a pharmacologic profile of mcn-3495 [n-(1-methyl-2-pyrrolidinylidene)-n'-phenyl-1-pyrrolidinecarboximidamide], a new, orally effective hypoglycemic agent.mcn-3495, a new compound unrelated strucuturally to the sulfonylureas or phenformin, has been found to produce a hypoglycemic effect in nondiabetic rats, dogs, mice, and monkeys. the minimum effective dose of mcn-3495 that lowers fasting blood glucose and improves glucose tolerance was found to be about 2.5 to 5 mg-per kilogram, per os, except in fasted monkeys, in which a tenfold greater potency was observed. when mcn-3495 was given repeatedly for three to five days, no tolerance to the hypogly ...197898377
distribution of 4-nitroquinoline 1-oxide reductase in the mucosa of canine digestive tract.the distribution of 4-nitroquinoline 1-oxide (4-nqo) reductase, assumed to be closely related to the carcinogenesis of 4-nqo, was investigated in the mucosa of canine digestive tract, and its results indicated following points. 1) the activity of 4-nqo reductase was highest in the esophagus, next in the stomach, and remarkably low in the small and large intestines. 2) there is no significant difference in the 4-nqo reductase activity between the upper, middle, and lower portion of the esophagus, ...197898382
formylation of initiator trna methionine in procaryotic protein synthesis: in vivo polarity in lactose operon expression.eucaryotic and procaryotic organisms differ in two aspects of their translation machinery: polycistronic messengers are expressed as a sequence of individual proteins only in procaryotes, and the initiation of protein synthesis proceeds with an initiator trna which is found to be modified (formylated) in procaryotes and not in eucaryotes. in the present study, we show that formylation is required in vivo for the coordinate expression of the escherichia coli lactose operon. our experiments are co ...197898518
isolation of immunoglobulin from splenic lymphocytes of inbred rats by triton x-100 solubilization. 197898589
physiological disposition and biotransformation of l-alpha-[2-3h]acetylmethadol (laam) in acutely and chronically treated monkeys. 197898628
signal to noise enhancement in a study of cell wall structure of bacillus subtilis by interactive computation.this paper describes a technique for obtaining values of the width and variation in optical density of sectioned bacterial cell walls by interactive computational methods. background 'noise' prevents accurate determination of cell wall boundaries from the data in a single scan line but the noise may be suppressed by averaging several consecutive scan lines. although application of the technique is explained for sectioned bacterial cell walls, it is equally valid for similar situations where sing ...197898638
catecholamine-induced alterations in glucose homeostasis in baboons, dogs, rabbits, and rats: comparative effects of somatostatin. 197898685
[value of the use of a cement containing a combination of triamcinolone and tetracycline in cavity preparations].odontomix (reg'd) cement was used at the bottom of cavities prepared in healthy dog canines in a attempt to prevent pulp and dentine alterations caused by the preparation and filling of cavities. 24 dogs were used along with 24 controls. i.v. tetracycline was afterwards given 10 times at weekly intervals. examination of tetracycline labelling under the cavities showed that the cement caused pulp and dentine changes in confined areas, though it has not yet been possible to determine whether these ...197898698
bacteriophages, vaccines, and people: an assessment of risk. 197898771
plasma membrane vesiculation: a cellular response to injury.the shedding of plasma membrane vesicles has been shown to result from exposure of monolayer cell cultures to formaldehyde and other sulfhydryl blocking agents. incubation of cells in concentrations of these agents as low as 5 to 10 mm for intervals as brief as fifteen minutes is effective (scott, 1976). plasma membrane vesiculation has been shown to be an energy-dependent process that requires ca++ and physiological temperature. following plasma membrane vesiculation, cell monolayers appear int ...197898904
ultrastructural study on the extrusion of multivesicular bodies from cardiac cells.cardiac conducting fibers taken from 12 dogs were studied in the electron microscope. the majority of samples contained a moderate number of multivesicular bodies (mvb's) and an extremely high number occurred in one dog. single mvb's were found in the perinuclear region and in the cytoplasm separating myofibrils. a high accumulation of mvb's occurred at the cell periphery within cytoplasmic stalks extending into the extracellular space, in the intercalated disc, and also outside of the cell. the ...197898908
cell proliferation in dimethylhydrazine-induced colonic adenocarcinomata following cytotoxic drug treatment.a stathmokinetic technique was used to study cell proliferation in dimethylhydrazine-induced adenocarcinomata of rat colon following treatment with cytotoxic drugs. the rate of cell division was significantly increased three days after treatment with 5,7-dihydroxytryptamine and seven days after treatment with 5-fluorouracil. acceleration of tumour cell proliferation following 5,7-dihydroxytryptamine treatment was inhibited by treating animals with the antiseritoninergic drug xylamidine tosylate. ...197898910
abnormalities of the nuclear envelope in porcine muscle affected with congenital myofibrillar hypoplasia.the nuclear ultrastructure of muscle fibres in congenital myofibrillar hypoplasia of piglets was studied in order to provide more information on the pathological changes present. in the initial stages of the disease, muscle fibres with a small reduction of myofibrils often had an increased number of nuclear pores. in the more advanced stages of the disease, the following nuclear abnormalities were observed in muscle fibres showing an extensive disintegration of myofibrils: 1) large dilations of ...197898911
age-associated changes in the blood picture of the goat. 197898936
enzymic profile of the semen of bovines (bubalus bubalis and bos taurus). ii. parallelism between acid and alkaline phosphatases and various measures of semen quality. 197898938
metabolism of histamine during anaphylactic shock in guinea-pigs [proceedings]. 197898974
microradiographic demonstration of pyelolymphatic backflow in the porcine kidney.pyelolymphatic backflow occurs when intrapelvic pressure rises acutely. although peripelvic and hilar lymphatics have occasionally been demonstrated during intravenous urography and retrograde pyelography, the patterns of intrarenal microlymphatic filling have not previously been studied radiographically in multipapillary kidneys. microradiography was performed after retrograde ureteral injections of barium sulfate suspension in recently excised pig kidneys. contrast filled the ducts of bellini ...197898998
jaundice and breast-feeding among alaskan eskimo newborns.the course, incidence, and severity of neonatal jaundice was studied in 95 alaskan eskimo infants. breast-fed infants had higher bilirubin concentrations than bottle-fed babies. both groups experienced high bilirubin levels, similar to those previously reported in navajo and oriental infants but greater than those observed in whites and blacks. a marked capacity to inhibit hepatic glucuronyl transferase was observed in breast-milk specimens but only partly accounted for the bilirubin differences ...197899026
multiple myeloma (light chain disease) with rheumatoid-like amyloid arthropathy and mu-heavy chain fragment in the serum.a 52 year old man presented with multiple myeloma and widespread amyloidosis involving joints, bursae- carpal tunnels, lymph nodes and subcutaneous tissue. osteolytic bone lesions and pathologic fracture of the neck of the left femur were found. bone marrow was infiltrated with both plasmacytes and lymphocytes. the majority of plasma cells contained large cytoplasmic vacuoles. free kappa ii type light chains and mu-heavy chain fragment were detected in the serum, and kappa ii type bence jones pr ...197899035
pars plana vitrectomy as a primary treatment for acute bacterial endophthalmitis.we successfully treated six patients with culture-proven acute bacterial endophthalmitis by a combination of emergency pars plana vitrectomy and the instillation of intravitreal antibiotics. all six patients regained satisfactory vision.197899040
catheter infection factors affecting total parenteral nutrition.during the five-year interval from january 1, 1971 to january 1, 1976 118 seriously ill adults received 2916 patient days of tpn therapy with an average infection rate of 7.6%. all patients received the benefit of a well-defined tpn catheter care protocol which emphasized regular (every 48 hours) catheter dressing changes. the lowest risk of infection, 2.7%, was seen in 73 patients who received an amino acid-glucose solution through a silicone elastomer catheter protected by an iodophor dressing ...197899066
antagonistic interaction of rifampicin and trimethoprim. 197899420
susceptibility of noxythiolin resistant organisms to povidone iodine. 197899421
[salmonella infections]. 197899539
studies on delayed hypersensitivity to protein antigen. induction of delayed hypersensitivity by chemically modified was shown in our previous paper that mice primed with chemically modified bacterial alpha-amylase (baa), which was neither cross-reactive with anti-baa antibody nor able to induce a humoral anti-baa response, developed enhanced responses to a subsequent challenge with native baa and that the magnitude of the immunological memory was closely related to the priming dose of modified baa. this paper describes the experimental conditions for induction of delayed hypersensitivity (dh) by modified b ...197899645
evidence for an essential dna component in the scrapie agent. 197899663
development of leucocytozoon caulleryi in chick embryos infected by biting of culicoides arakawae through shell membrane.chick embryos were infected with leucocytozoon caulleryi by biting of the midge, culicoides arakawae, through the shell membrane. schizonts of l. caulleryi were detected in the chorioallantoic membrane and most of the internal organs of embryos and of chicks after hatching. the development of schizonts was slower in embryos than in chickens. soluble antigens of l. caulleryi were demonstrated by the precipitation test in the allantoic fluid and blood from the embryos and chicks. no erythrocytic s ...197899671
behavioral measurement measurements of excitability changes in reward sites in the dog: a frequency dependent effect. 197899757
[proteins of human body--clinical and diagnostic aspects. practical clinical aspects of studies on protein metabolism]. 197899770
modified peptidoglycan transpeptidase activity in a carbenicillin-resistant mutant of pseudomonas aeruginosa 18s.a carbenicillin-resistant mutant of pseudomonas aeruginosa 18s was found to possess peptidoglycan transpeptidase activity significantly more resistant to inhibition by benzyl penicillin, ampicillin, carbenicillin, and cephaloridine than that of the parent strain. the mutant was more resistant than the parent strain to all of the beta-lactam antibiotics tested, and 50% inhibition values for these compounds against membrane-bound model transpeptidase activity paralleled this increase. the resistan ...1978100051
morphology of freeze-etched treponema refringens (nichols).the freeze-etch technique was used to study the morphology of treponema refringens (nichols). there is a single band of cytoplasmic fibrils which follows a path in the form of a right-handed helix with a periodicity of 1500 nm around the body of the treponeme just below the cytoplasmic membrane. there are two major fracture planes, one located in the interior of the outer envelope and the second in the interior of the cytoplasmic membrane. the "blebs" or "surface protuberances", which are quite ...1978100069
effects of 5-hydroxylysine on acetylene reduction and nh4+-assimilation in the cyanobacterium anabaena cylindrica. 1978100112
increased sensitivity for detection of carcinogen-induced dna repair with the chain terminator dideoxythymidine. 1978100116
control of cell multiplication: preparation and immunological comparison of inhibitory factors in the homogenate and perfusate of the adult rat liver.the control of organ cell multiplication by a negative feed-back mechanism implies that factors of the inhibitory mechanism are present in the blood and are produced by the target organ itself. we have examined the inhibitors which are present in the cytosol of adult rat liver as well as in efferent fluid from an isolated perfused organ. these two materials yielded predominantly protein molecules having in common a molecular weight of approximately 80 000 daltons and an isoelectric point between ...1978100149
fat loading tests in haemorrhagic hyperlipidaemia in rabbits. 1978100328
environmental contaminants. 1978100350
inhalation anthrax in a home craftsman.inhalation anthrax with complicating subarachnoid hemorrhage due to simultaneous infection with two capsular biotypes of bacillus anthracis of different virulence for the mouse is reported. the patient, a home craftsman, acquired his infection from imported animal-origin yarn.1978101438
rifampicin plus nalidixic acid: a rational combination for the treatment of urinary infection. 1978101503
characterization of the bacillus subtilis bacteriophage pbs2-induced dna polymerase and its associated exonuclease activity.the dna polymerase induced by bacillus subtilis bacteriophage pbs2 has a stokes radius of 7.2 in buffers of high ioninc strength, suggesting a molecular weight in the range 145,000 to 195,000. the polypeptide bands observed on gel electrophoresis in dodecyl sulfate have apparent molecular weights of 78,000 and 69,000 (and possibly another 27,000) in equimolar amounts. in buffers of low ionic strength, the enzyme appears to form large aggregates and even precipitates, with about 90% loss of activ ...1978101539
[studies of antibody against shigella in bacillary dysentery patients and carriers. report 4. comparison of the results obtained from igg antibody absorption with protein a-sepharose cl-4b and from those with indirect radioimmunoassay (author's transl)]. 1977101599
[studies on moraxella. i. a new selective medium for moraxella sp. (author's transl)]. 1977101603
[salmonellosis]. 1978101617
[epidemiological study on beta hemolytic streptococci among healthy school children in toda city, saitama (author's transl)]. 1978101618
[clinical studies of childhood empyema experienced for the past 12 years (author's transl)]. 1978101626
effect of hypotension induced by sodium nitrocyanoferrate (iii) on the release of arginine-vasopressin in the unanaesthetized monkey. 1978101639
transmission of hepatitis b to the rhesus monkey. studies on the humoral and cell-mediated immune response.the susceptibility of the rhesus monkey (macaca mulatta) to hepatitis b virus was enhanced by the induction of chronic infection with plasmodium inuei.1978101663
clinical studies on pipemidic acid. 1978101691
effect of certain sulphydryl compounds and dimethyl sulphoxide on potassium release by certain amines and proteins from pseudomonas aeruginosa.dithiothreitol, cysteine, and mercapto-ethanol inhibit k+ release from cells of pseudomonas aeruginosa by amines and nh4cl incubated at ph 8.5. the inhibitions are competitive for the monamines and nh4cl but non-competitive for the diamines and spermidine. the percent inhibition is largest for tryptamine, least for spermidine and ethylene diamine. dmso inhibits k+ release by monamines and certain proteins but not significantly by diamines and histamine. the inhibitions are competitive.1977101739
testing the trh hypothesis of pineal the syrian hamster gonadal involution may be induced by exposure of the animal to darkness, short photoperiod, or blindness for several weeks. these conditions also influence body metabolism by inducing a substantial decrease in thyroxin concentrations. the role of the pineal gland in these phenomena has been demonstrated by experiments showing that if pinealectomized hamsters are subjected to darkness, short photoperiod, or blindness, their gonads do not involute and plasma thyroxin levels r ...1978101748
primum non nocere and the sydney funnel-web spider (continued). 1978101753
quantitative structure-activity relationships in the 2,4,5-ring substituted phenylisopropylamines.the potency of a series of 2,4,5-ring substituted phenylisopropylamines was examined using the rabbit hyperthermia assay. an excellent correlation (r = 0.99) was found between the rabbit hyperthermic and human psychotomimetic potencies. in the hyperthermic model, the 4-x-substituted-2,5-dimethoxyphenylisopropylamines were found to be one to two orders of magnitude more potent than the 2-x- or 5-x-substituted positional isomers (x = -h, -ch3, -sch3, -br). conformational perturbations induced by s ...1978101881
[the effect of prolonged irradiation and of certain radioprotective agents on glycosaminoglycans in the rat]. 1978101997
[mathematical model of the transformation of viral hepatitis into chronic disease. preliminary results. i. specification of global descriptive parameters of hepatic inflammation]. 1978101998
quantitative assessment of bactericidal activities of beta-lactam antibiotics by agar plate method.quantitative bactericidal activities of beta-lactam antibiotics were determined by the agar plate method. broth cultures, of which the colony-forming units were counted before the study, were inoculated on antibiotic-containing agar plates, utilizing a 10(-3), 10(-2), or 10(-1) dilution or undiluted culture plated with each 0.001-ml calibrated loop. these plates were incubated at 37 degrees c overnight, and the minimal drug concentration at which no bacterial growth was observed on the plates wa ...1978102246
in vitro activity of hr 756, a new cephalosporin compound.the in vitro activity of hr 756, a new cephalosporin, has been determined against recent clinical isolates and compared with that of other beta-lactam antibiotics. the geometric means of the minimum inhibitory concentrations (mic) for different isolates of escherichia coli (100 isolates), klebsiella pneumoniae (84), pseudomonas aeruginosa (121), proteus mirabilis (52), indole-positive proteus species (9), salmonella species (19), staphylococcus aureus penicillin-sensitive (29) and penicillin-res ...1978102631
changing concepts of pelvic inflammatory disease. 1978102712
susceptibility of the anaerobic bacteria, group d streptococci, enterobacteriaceae, and pseudomonas to semisynthetic penicillins: carbenicillin, piperacillin, and ticarcillin.sodium piperacillin t-1220, a new semisynthetic penicillin, was tested in vitro against 297 clinical isolates of anaerobic bacteria and 669 aerobic bacteria by the conventional agar dilution method and compared with carbenicillin and ticarcillin. at a 100-mug/ml concentration the three drugs showed comparable effectiveness against the anaerobes tested. however, at 20 mug/ml, piperacillin was the most effective drug against bacteroides fragilis, peptostreptococci, and group d streptococci. at thi ...1978103491
effect of two cancer chemotherapeutic agents on the antibacterial activity of three antimicrobial agents.cancer chemotherapeutic agents and antibacterial antibiotics are often given concomitantly. daunorubicin, cytosine arabinoside, and three antibiotics (gentamicin, amikacin, and ticarcillin) were tested individually and in combinations to determine their antimicrobial activity against pseudomonas aeruginosa, klebsiella pneumoniae, and escherichia coli. these cytotoxic agents are commonly employed in the therapy of acute nonlymphocytic leukemia for remission induction therapy, and these antimicrob ...1978103494
comparative disposition of sulindac and metabolites in five species. 1978103551
inhibition of acetylcholinesterase from foetal and maternal tissues after oral intake of carbaryl (1-naphthyl-n-methyl-carbamate) by pregnant rats. 1978103555
single-unit activity in the auditory cortex of monkeys selectively attending left vs. right ear stimuli.single-unit responses were recorded from the auditory cortex of rhesus monkeys that were performing an auditory selective attention task. acoustic stimuli were presented randomly to either the left or right ear through headphones. in a given block of trials one ear was selected as the ear to be attended, and was indicated by lighting either a left or right response key. the animal's task was to press the lighted key whenever stimuli were presented to the attended ear, but to make no response to ...1978103597
[effect of lymphokines produced in a grafted system on production of prostaglandins by macrophages].mice peritoneal macrophages cultured in vitro release a prostaglandin-like activity as evaluated by a bio-assay using rat stomach fundus. the prostaglandin release is greatly increased when macrophages are incubated with the supernatant of mixed lymphocyte cultures between recipient and donor of a skin allograft. this phenomenon was found in all strains of mice tested except c3h/hej mice, a strain already known for its defective responsiveness to bacterial lipopolysaccharide (lps).1978103646
evaluation of polymer flock and metal alloy intra-tubal device in pigtail monkeys.two intratubal devices, one covered with a flock made from ethylene vinyl acetate and the other constructed of titanium-aluminum-vanadium alloy with an etched surface were evaluated after being placed in the fallopian tubes of pigtail monkeys. in some instances, the devices were medicated with 10% silver nitrate or 50% quinacrine hydrochloride. the microflock device anchored in the tube mechanically, but there is no evidence that either the polymeric or metal alloy device formed an actual attach ...1978103682
[rate of nutrient absorption during active digestion and the possibility of using these data in the conduct of parenteral feeding]. 1978103700
influence of chenodeoxycholic acid on the kinetics of endogenous triglyceride transport in man.plasma lipids and triglycerides kinetics were studied in ten subjects before and after 6-8 weeks treatment with 1 g/day chenodeoxycholic acid for radiolucent gallstones. plasma triglyceride concentration fell by 20% and phospholipid concentration rose by 5% on average; there was no change in cholesterol or free fatty acids. body weight remained constant. triglyceride kinetics, studied by a precursor-labelling technique, revealed a reduction both of triglyceride plasma pool and turnover rate, acc ...1978103719
focal penicillin epilepsy in an isolated cerebral hemisphere. 1978103744
toxoplasma gondii: penetration into differentiating friend erythroleukemia cells. 1978103745
a new sequence-specific endonuclease from anabaena cylindrica. 1978103749
effect or oral administration of propylene glycol on the induction of enzymes and proteins in microsomes and cytosol of the rat liver.male wistar rats were divided into 4 groups, receiving water, propylene glycol (pg), sodium phenobarbital (pb) and pb + pg, respectively. after oral administration of these materials for 7 days, various enzymes in hepatic microsomes and the binding capacity of y and z fractions in the cytosol were assayed. as compared with the water group, the aniline hydroxylase activity, the cytochrome b5 content and the amount of z fraction increased in the pg group. as compared with the pb group, the microso ...1978103773
dietary lactose and the aetiology of human small-intestinal hypolactasia. 1978103781
production of anti-antipyrine antibody by immunization with 4-azoantipyrine-conjugated bovine serum albumin. 1978103791
[susceptibility testing with the autobac system (author's transl)].the autobac i provides an automated method for the rapid measurement of antimicrobial susceptibility of fast growing pathogenic microorganisms. to check instrument accuracy, 477 cultures were tested by the bauer-kirby method for comparison. according to the din limits, the results were comparable in 81.8%, whereas within the nccls limits the agreement was 86.5%. the discrepancy was found to be due to incorrect disc mass and different limits of inhibitory zone diameters. another reason for disagr ...1978103806
nonhuman primate model for the study of respiratory klebsiella pneumoniae infection.squirrel monkeys were inoculated by the intratracheal inoculation of 700 klebsiella pneumoniae organisms and developed lobar pneumonia in about 24 h. characteristic clinical findings were fever, anorexia, and coughing. laboratory findings included leukocytosis or leukopenia (with the latter more prominent in ultimately fatal infections), bacteremia, and shedding of bacteria into the pharynx. infected monkeys showed increased plasma lysozyme activity as well as increased plasma ceruloplasmin, hap ...1978103826
effect of nitroglycerin on vulnerability to ventricular fibrillation during myocardial ischemia and reperfusion.the effect of nitroglycerin on vulnerability to ventricular fibrillation was examined in 44 chloralose-anesthetized dogs. in 19 animals ventricular fibrillation threshold was measured before and during a 10 minute period of occlusion of the left anterior descending coronary artery followed by abrupt release of occlusion. fibrillation threshold was determined using the single stimulus and train of stimuli methods. the influence of nitroglycerin on vulnerability was assessed with and without preve ...1979104608
activity of bepridil and other anti-anginals on cardiovascular modifications engendered by conditioned anxiety in the dog.the action of bepridil (5 mg/kg), perhexilene (5 mg/kg) propranolol (0.5 mg/kg), dipyridamole (0.5 mg/kg), amiodarone (10 mg/kg), pentaerythritol tetranitrate (40 microgram/kg) and nitroglycerine (40 microgram/kg) on cardiovascular manifestations of auditory-inducted emotional stress has been investigated in the conscious dog. bepridil, perhexilene and propranolol considerably reduce tachycardia provoked by the anxiogenic stimulus, with nitroglycerin exerting an attenuated effect and the others ...1978104675
bronchial mucosal permeability.the tracheobronchial epithelium has well-developed tight junctions which on a morphologic basis should be markedly resistant to penetration by protein molecules. despite this, antigen inhalation in monkeys allergic to ascaris suum results in the rapid onset of pulmonary physiologic changes. recent studies in man and animals have shown that a substantial number of mast cells exist in the bronchial lumen and epithelium. we suggest that antigen-antibody interaction initially occurs on these superfi ...1979104888
passage of immunoglobulins from plasma to the oral cavity in rhesus monkeys.the passage of immunoglobulin from plasma to the oral cavity was studied in rhesus monkeys. immunoglobulins g, a and m were purified from pooled rhesus monkey serum, radiolabelled with 125i and injected intravenously into twelve monkeys. sequential samples of oral fluids were taken over a 24 h period and were assayed for radioactivity. radioactivity could be detected in crevicular fluid washings after 0.5 h in monkeys injected with igg and iga, and after 2 h in monkeys given igm. maximal levels ...1978104924
sarcocystis in feces of coyotes from montana: prevalence and experimental transmission to sheep and cattle. 1978104939
p-hydroxyphenylacetaldoxime, an inhibitor of beta-galactosidase, produced by actinomycetes. 1979104950
synergy between aminoglycosides and semi-synthetic penicillins against gentamicin-resistant gram-negative rods. 1979104951
carbon and nitrogen repression of arginine catabolic enzymes in bacillus subtilis.specific activities of arginase and ornithine aminotransferase, inducible enzymes of arginine catabolism in bacillus subtilis 168, were examined in cells grown with various carbon and nitrogen sources. levels of these enzymes were similar in arginine-induced cultures whether glucose or citrate was the carbon source (in contrast to histidase), suggesting that carbon source catabolite repression has only limited effect. in media with combinations of nitrogen sources, glutamine strongly repressed i ...1979104957
transcription and translation in a pleiotropic streptomycin-resistant mutant of escherichia coli.the role of the ribosomal protein s12 (streptomycin protein) in ribosome function and in other metabolic processes in the cell has been investigated. a spontaneous streptomycin-resistant strain of escherichia coli (sm3) carrying a mutation in the rpsl gene is deficient in its ability to induce the synthesis of the enzyme bets-galactosidase. it was demonstrated that the reduced rate of enzyme synthesis results from deficiencies in both the transcription of the lactose operon and translation of th ...1979104958
isolation of an iron-binding compound from pseudomonas iron-binding compound was isolated from ethyl acetate extracts of culture supernatant fluids of pseudomonas aeruginosa and was purified by successive paper and thin-layer chromatographic procedures. the purified compound was characterized by uv, visible, infrared, and fluorescence spectroscopy. the compound possesses phenolic characteristics, with little or no similarity to dihydroxybenzoates and no indication of a hydroxamate group. p. aeruginosa synthesized the compound during active growth ...1979104968
implications for adult roles from differential styles of mother-infant bonding: an ethological study.ethological observations of maternal and infant behaviors of nine vervet monkey pairs (cercopithecus aethiops sabaeus) showed the effects of differential styles of early maternal responsiveness on later infant competence. those infants receiving the least amount of maternal responsiveness and the most time-off the mother in the first 3 months of development were more socially competent at 6 months of age. the results are discussed within current ethological "attachment" theories. the detachment ...1979105083
muscle responses and monosynaptic reflexes in falling monkey. role of the vestibular system.the free fall has been used in our laboratory as a way to test vestibular function in baboons in order to quantify vestibular compensation in the hemilabyrinthectomized animal. this study presents only those results that concern the contribution of the vestibular system to muscle responses due to sudden fall. emg activity was recorded from the fully conscious animal using chronic electrodes implanted in various muscles. spinal monosynaptic reflexes (hoffmann's and tendon reflexes) were studied i ...1978105128
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