Publications

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antibody-based immunotherapy to treat and prevent infection with hypervirulent klebsiella pneumoniae.hypervirulent klebsiella pneumoniae (hvkp) strains are predicted to become a major threat in asia if antibiotic resistance continues to spread. anticapsular antibodies (abs) were developed because disseminated infections caused by hvkp are associated with significant morbidity and mortality, even with antibiotic-sensitive strains. k1-serotype polysaccharide capsules (k1-cps) are expressed by the majority of hvkp strains. in this study, k1-cps-specific igg abs were generated by conjugation of k1- ...201727795303
antimicrobial assay and genetic screening of selected freshwater cyanobacteria and identification of a biomolecule dihydro-2h-pyran-2-one derivative.explorations of freshwater cyanobacteria as antimicrobial (bacteria, fungi and methicillin-resistant staphylococcus aureus (mrsa) strains) drug resource using bioassay, nrps (non-ribosomal polypeptide synthetase) and pks (polyketide synthase) genes, as well as in silico approach.201728004519
synthesis and antimicrobial evaluation of ester-linked 1,4-disubstituted 1,2,3-triazoles with a furyl/thienyl moiety.twenty ester-linked 1,4-disubstituted 1,2,3-triazoles having a furyl/thienyl moiety have been synthesized from heteroaryl prop-2-yn-1-yl carboxylate and aromatic azides via a cu(i) catalyzed 1,3-dipolar cycloaddition. all the synthesized compounds were characterized by ftir, [formula: see text]h nmr, [formula: see text]c nmr spectroscopy and hrms. synthesized triazoles were tested in vitro for antimicrobial evaluation against gram-negative bacteria-escherichia coli, enterobacter aerogenes and kl ...201727900513
evasion of neutrophil extracellular traps by respiratory pathogens.the release of neutrophil extracellular traps (nets) is a major immune mechanism intended to capture pathogens. these histone- and protease-coated dna structures are released by neutrophils in response to a variety of stimuli, including respiratory pathogens, and have been identified in the airways of patients with respiratory infection, cystic fibrosis, acute lung injury, primary graft dysfunction, and chronic obstructive pulmonary disease. net production has been demonstrated in the lungs of m ...201727854516
clinical and microbiological characteristics of bloodstream infections among patients with haematological malignancies with and without neutropenia at a medical centre in northern taiwan, 2008-2013.this study aimed to investigate the epidemiology and microbiology of bloodstream infections (bsis) in patients with haematological malignancies. clinical characteristics and microbiology of 2083 patients with haematological malignancy who were treated for bsi from 2008 to 2013 at a medical centre in taiwan were retrospectively reviewed. lymphoma (38.1%) was the most common, followed by acute myeloid leukaemia (30.9%). of the 2090 non-duplicate bsi isolates, 1310 (62.7%) were recovered from patie ...201728109554
secondary bacterial isolates from previously untreated buruli ulcer lesions and their antibiotic susceptibility patterns in southern nigeria.mycolactones, secreted by mycobacterium ulcerans, were previously believed to prevent super infection in buruli ulcer lesions. however, little is known about secondary bacterial infections in these lesions. this study evaluated contaminating bacterial flora and their antibiotic susceptibility patterns in cases of previously untreated buruli ulcer disease from three states in southern nigeria.201728001222
the influence of the autochthonous wastewater microbiota and gene host on the fate of invasive antibiotic resistance genes.the aim of this study was to assess the fate of invasive antibiotic resistance genes (arg) discharged in wastewater. with this objective, antibiotic resistant bacteria (arb) known to harbor specific arg were inoculated in wastewater (hospital effluent, or municipal raw and treated wastewater) and in ultra-pure sterile water microcosms. two sets of wastewater arb isolates were used - set 1, enterococcus faecalis, acinetobacter johnsonii, klebsiella pneumoniae and set 2, enterococcus faecium, acin ...201727697350
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