Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| antimicrobial susceptibility among european gram-negative and gram-positive isolates collected as part of the tigecycline evaluation and surveillance trial (2004-2014). | european centers (n = 226) involved in the tigecycline evaluation and surveillance trial (test, 2004-2014) submitted data and bacterial isolates. | 2017 | 27216271 |
| c-terminal modification and multimerization increase the efficacy of a proline-rich antimicrobial peptide. | two series of branched tetramers of the proline-rich antimicrobial peptide (pramp), chex1-arg20, were prepared to improve antibacterial selectivity and potency against a panel of gram-negative nosocomial pathogens including escherichia coli, klebsiella pneumoniae, acinetobacter baumannii and pseudomonas aeruginosa. first, tetramerization was achieved by dithiomaleimide (dtm) conjugation of two c-terminal-cysteine bearing dimers that also incorporated c-terminal peptide chemical modification. dtm ... | 2017 | 27862429 |
| colistin: still a lifesaver for the 21st century? | living in the 'era of antibiotic resistance' and facing the threat of an 'end to antibiotics', physicians in the last decade have revived use of colistin, since the available literature at the clinical level was poor and limited areas covered: herein, the authors present the current available knowledge regarding colistin, i.e. in vitro activity and interactions, current pharmacokinetics/pharmacodynamics (pk/pd), clinical efficacy against multidrug-resistant (mdr) and extensively drug-resistant ( ... | 2017 | 27573251 |
| rapid detection of antibiotic resistance in gram-negative bacteria through assessment of changes in cellular morphology. | rapid antimicrobial susceptibility testing has the potential to improve patient outcomes and reduce healthcare-associated costs. in this study, a novel assay based on bacterial cell elongation after exposure to an antibiotic (ceftazidime) was evaluated for its ability to rapidly detect resistance in gram-negative bacteria. the assay was used to detect resistance in a large collection of strains containing 320 clinical isolates of acinetobacter baumannii, 171 clinical isolates of klebsiella pneum ... | 2017 | 27259183 |
| hospital-wide comparison of health care-associated infection among 8 intensive care units: a retrospective analysis for 2010-2015. | exploring the distribution of nosocomial pathogens among different categories of intensive care units (icus) is critical to improving the management of health care-associated infection (hai). despite both single- and multicenter studies, the nature of the variations of hais within various icus remains inadequately evaluated. | 2017 | 27856076 |
| polymyxin monotherapy or in combination against carbapenem-resistant bacteria: systematic review and meta-analysis. | the objective of this study was to summarize available data on polymyxin-based combination therapy or monotherapy for carbapenem-resistant gram-negative bacteria. | 2017 | 27624572 |
| prevalence and emergence of carbapenemases-producing gram-negative bacteria in mediterranean basin. | the emergence and the global spread of carbapenemases concern to health services worldwide. their celestial rise among gram-negative bacilli has challenged both the scientific and pharmaceutical sectors. indeed, infections caused by these bacteria have limited treatment options and have been associated with high mortality and morbidity rates. carbapenemase producers are mainly identified among klebsiella pneumoniae, escherichia coli, pseudomonas aeruginosa, and acinetobacter baumannii and still ... | 2017 | 27387224 |
| first detection of vim-4-producing pseudomonas aeruginosa and oxa-48-producing klebsiella pneumoniae in northeastern (annaba, skikda) algeria. | the aim of the study was to investigate the prevalence and molecular support of carbapenem resistance in gram-negative bacilli clinical isolates collected between march 2013 and march 2015 in three cities (annaba, skikda, and guelma) in northeastern algeria. | 2017 | 27314660 |
| in vitro antimicrobial activity of five essential oils on multidrug resistant gram-negative clinical isolates. | the emergence of drug-resistant pathogens has drawn attention on medicinal plants for potential antimicrobial properties. the objective of the present study was the investigation of the antimicrobial activity of five plant essential oils on multidrug resistant gram-negative bacteria. | 2017 | 27366345 |
| bloodstream infections in febrile neutropenic patients at a tertiary cancer institute in south india: a timeline of clinical and microbial trends through the years. | febrile neutropenia (fn) is an oncological emergency. the choice of empiric therapy depends on the locally prevalent pathogens and their sensitivities, the sites of infection, and cost. the infectious diseases society of america guidelines are being followed for the management of fn in india. | 2017 | 27688611 |
| green synthesis of silver nanoparticles using pimpinella anisum seeds: antimicrobial activity and cytotoxicity on human neonatal skin stromal cells and colon cancer cells. | the present study focused on a simple and eco-friendly method for the synthesis of silver nanoparticles (agnps) with multipurpose anticancer and antimicrobial activities. | 2017 | 27660438 |
| antimicrobial susceptibility of gram-negative eskape pathogens isolated from hospitalized patients with intra-abdominal and urinary tract infections in asia-pacific countries: smart 2013-2015. | gram-negative eskape pathogens (klebsiella pneumoniae, acinetobacter baumannii, pseudomonas aeruginosa and enterobacter spp.) are responsible for increases in antimicrobial-resistant infections worldwide. we determined in vitro susceptibilities to eight parenteral antimicrobial agents using clinical and laboratory standards institute broth microdilution methodology for gram-negative eskape pathogens isolated from hospitalized patients with intra-abdominal infections (iais) (n=3052) and urinary t ... | 2017 | 28051952 |
| phenotypic and genomic characterization of the antimicrobial producer rheinheimera sp. eprs3 isolated from the medicinal plant echinacea purpurea: insights into its biotechnological relevance. | in recent years, there has been increasing interest in plant microbiota; however, despite medicinal plant relevance, very little is known about their highly complex endophytic communities. in this work, we report on the genomic and phenotypic characterization of the antimicrobial compound producer rheinheimera sp. eprs3, a bacterial strain isolated from the rhizospheric soil of the medicinal plant echinacea purpurea. in particular, eprs3 is able to inhibit growth of different bacterial pathogens ... | 2017 | 27884784 |
| antibacterial effect of sevoflurane and isoflurane. | multidrug resistant bacteria are increasing worldwide and therapeutic options are limited. some anaesthetics have shown antibacterial activity before. in this study, we have investigated the antibacterial effect of the halogenated anaesthetic agents sevoflurane and isoflurane against a range of resistant pathogens. | 2017 | 28198170 |
| cathelicidin antimicrobial peptide from alligator mississippiensis has antibacterial activity against multi-drug resistant acinetobacter baumanii and klebsiella pneumoniae. | alligator mississippiensis (american alligator), a member of order crocodilia, lives in bacteria-laden environments but is not often known to succumb to bacterial infections. their serum has been shown to have antibacterial activity beyond that of human serum, and it is believed that this activity is partially due to cationic antimicrobial peptides (camps). camps are produced by many organisms as part of the innate immune system. camps are attractive possible therapies against multi-drug resista ... | 2017 | 28089718 |
| predation efficacy of bdellovibrio bacteriovorus on multidrug-resistant clinical pathogens and their corresponding biofilms. | the aim of the present study was to evaluate the predation efficacy of bdellovibrio bacteriovorus on multidrug-resistant (mdr) or extensive drug resistant (xdr) gram-negative pathogens and their corresponding biofilms. in this study, we examined the ability of b. bacteriovorus to prey on mdr and xdr gram-negative clinical bacteria, including escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa and acinetobacter baumannii. results showed that b. bacteriovorus was able to prey on all pl ... | 2017 | 28367880 |
| effect of nebulized eucalyptus on contamination of microbial plaque of endotracheal tube in ventilated patients. | formation of biofilm and bacterial colonization within the endotracheal tube (ett) are significant sources of airway contamination and play a role in the development of ventilator-associated pneumonia (vap). this study was conducted to examine the effect of nebulized eucalyptus (ne) on bacterial colonization of ett biofilm. | 2017 | 27095990 |
| in vitro activity of a polyhexanide-betaine solution against high-risk clones of multidrug-resistant nosocomial pathogens. | to determine the in vitro activity of a polyhexanide-betaine solution against collection strains and multidrug-resistant (mdr) nosocomial isolates, including high-risk clones. | 2017 | 27004429 |
| epidemiological study of prevalence, determinants, and outcomes of infections in medical icu at a tertiary care hospital in india. | to determine the prevalence of infections, risk factors, and outcomes in a medical intensive care unit (icu), we performed a hospital-based study. | 2017 | 26628756 |
| secondary bacterial isolates from previously untreated buruli ulcer lesions and their antibiotic susceptibility patterns in southern nigeria. | mycolactones, secreted by mycobacterium ulcerans, were previously believed to prevent super infection in buruli ulcer lesions. however, little is known about secondary bacterial infections in these lesions. this study evaluated contaminating bacterial flora and their antibiotic susceptibility patterns in cases of previously untreated buruli ulcer disease from three states in southern nigeria. | 2017 | 28001222 |
| the influence of the autochthonous wastewater microbiota and gene host on the fate of invasive antibiotic resistance genes. | the aim of this study was to assess the fate of invasive antibiotic resistance genes (arg) discharged in wastewater. with this objective, antibiotic resistant bacteria (arb) known to harbor specific arg were inoculated in wastewater (hospital effluent, or municipal raw and treated wastewater) and in ultra-pure sterile water microcosms. two sets of wastewater arb isolates were used - set 1, enterococcus faecalis, acinetobacter johnsonii, klebsiella pneumoniae and set 2, enterococcus faecium, acin ... | 2017 | 27697350 |
| clinical and microbiological characteristics of bloodstream infections among patients with haematological malignancies with and without neutropenia at a medical centre in northern taiwan, 2008-2013. | this study aimed to investigate the epidemiology and microbiology of bloodstream infections (bsis) in patients with haematological malignancies. clinical characteristics and microbiology of 2083 patients with haematological malignancy who were treated for bsi from 2008 to 2013 at a medical centre in taiwan were retrospectively reviewed. lymphoma (38.1%) was the most common, followed by acute myeloid leukaemia (30.9%). of the 2090 non-duplicate bsi isolates, 1310 (62.7%) were recovered from patie ... | 2017 | 28109554 |
| synthesis and antimicrobial evaluation of ester-linked 1,4-disubstituted 1,2,3-triazoles with a furyl/thienyl moiety. | twenty ester-linked 1,4-disubstituted 1,2,3-triazoles having a furyl/thienyl moiety have been synthesized from heteroaryl prop-2-yn-1-yl carboxylate and aromatic azides via a cu(i) catalyzed 1,3-dipolar cycloaddition. all the synthesized compounds were characterized by ftir, [formula: see text]h nmr, [formula: see text]c nmr spectroscopy and hrms. synthesized triazoles were tested in vitro for antimicrobial evaluation against gram-negative bacteria-escherichia coli, enterobacter aerogenes and kl ... | 2017 | 27900513 |
| antimicrobial assay and genetic screening of selected freshwater cyanobacteria and identification of a biomolecule dihydro-2h-pyran-2-one derivative. | explorations of freshwater cyanobacteria as antimicrobial (bacteria, fungi and methicillin-resistant staphylococcus aureus (mrsa) strains) drug resource using bioassay, nrps (non-ribosomal polypeptide synthetase) and pks (polyketide synthase) genes, as well as in silico approach. | 2017 | 28004519 |
| evaluating bionanoparticle infused fungal metabolites as a novel antimicrobial agent. | therapeutic properties of fungal metabolites and silver nanoparticles have been well documented. while fungal metabolites have been used for centuries as medicinal drugs, potential of biogenic silver nanoparticles has recently received attention. we have evaluated the antimicrobial potential of aspergillus terreus crude extract, silver nanoparticles and an amalgamation of both against four pathogenic bacterial strains. antimicrobial activity of the following was evaluated - a. terreus extract, b ... | 2017 | 27429931 |
| evasion of neutrophil extracellular traps by respiratory pathogens. | the release of neutrophil extracellular traps (nets) is a major immune mechanism intended to capture pathogens. these histone- and protease-coated dna structures are released by neutrophils in response to a variety of stimuli, including respiratory pathogens, and have been identified in the airways of patients with respiratory infection, cystic fibrosis, acute lung injury, primary graft dysfunction, and chronic obstructive pulmonary disease. net production has been demonstrated in the lungs of m ... | 2017 | 27854516 |
| healthcare associated infections caused by coagulase-negative staphylococci in a neonatal intensive care unit. | this study sought to evaluate infections related to health care caused by coagulase-negative staphylococci in a neonatal intensive care unit by assessing antimicrobial susceptibility profiles and potentially effective antibiotic regimens. | 2017 | 24213088 |
| diversity of ammonia oxidation (amoa) and nitrogen fixation (nifh) genes in lava caves of terceira, azores, portugal. | lava caves are an understudied ecosystem in the subterranean world, particularly in regard to nitrogen cycling. the diversity of ammonia oxidation (amoa) and nitrogen fixation (nifh) genes in bacterial mats collected from lava cave walls on the island of terceira (azores, portugal) was investigated using denaturing gradient gel electrophoresis (dgge). a total of 55 samples were collected from 11 lava caves that were selected with regard to surface land use. land use types above the lava caves we ... | 2017 | 26778867 |
| microbiological and molecular characterization of extreme drug-resistant carbapenemase-producing klebsiella pneumoniae isolates. | fifteen klebsiella pneumoniae clinical isolates showing non-susceptibility to carbapenems and resistant to colistin were collected in an italian hospital. all isolates resulted negative to ampc, mbl and esbl production but positive to modified hodge test, therefore were evaluated as kpc producers. the presence of blakpc genes was verified by polymerase chain reaction (pcr) and sequencing. furthermore, molecular typing was performed by multilocus sequence typing (mlst). pcr analysis and nucleotid ... | 2017 | 24067478 |
| an unusual cause of acute abdomen-gas-forming liver abscess due to salmonella enteritidis. | gas-forming pyogenic liver abscess (gfpla) is considered to be a very severe form of pla and carries a high mortality. klebsiella pneumoniae is the most common pathogen responsible for the disease, whereas cases where salmonella is cited as the cause are very uncommon. we report the first case of a 53-year-old lady suffering from gfpla due to salmonella, who was successfully treated with surgical drainage. to the best of our knowledge, this is the first case of gfpla caused by salmonella enterit ... | 2017 | 23978428 |
| potentiation of antibiotic activity by a novel cationic peptide: potency and spectrum of activity of spr741. | novel approaches for the treatment of multidrug-resistant gram-negative bacterial infections are urgently required. one approach is to potentiate the efficacy of existing antibiotics whose spectrum of activity is limited by the permeability barrier presented by the gram-negative outer membrane. cationic peptides derived from polymyxin b have been used to permeabilize the outer membrane, granting antibiotics that would otherwise be excluded access to their targets. we assessed the in vitro effica ... | 2017 | 28533232 |
| antimicrobial consumption, costs and resistance patterns: a two year prospective study in a romanian intensive care unit. | due to the vulnerable nature of its patients, the wide use of invasive devices and broad-spectrum antimicrobials used, the intensive care unit (icu) is often called the epicentre of infections. in the present study, we quantified the burden of hospital acquired pathology in a romanian university hospital icu, represented by antimicrobial agents consumption, costs and local resistance patterns, in order to identify multimodal interventional strategies. | 2017 | 28532467 |
| optimization of cord blood unit sterility testing: impact of dilution, analysis delay, and inhibitory substances. | different methods are used by cord blood banks to prepare samples for sterility testing. suboptimal methods can result in the release of contaminated products. in our organization, samples are prepared by diluting the final product in rpmi-1640 medium. in this work, we have compared our method with different approaches to verify whether optimization should be sought. | 2017 | 28474347 |
| epidemiology and trends in the antibiotic susceptibilities of gram-negative bacilli isolated from patients with intra-abdominal infections in the asia-pacific region, 2010-2013. | this study was conducted to investigate the epidemiology and antimicrobial susceptibility patterns of gram-negative bacilli (gnb) isolated from intra-abdominal infections (iais) in the asia-pacific region (apr) from 2010-2013. a total of 17 350 isolates were collected from 54 centres in 13 countries in the apr. the three most commonly isolated gnb were escherichia coli (46.1%), klebsiella pneumoniae (19.3%) and pseudomonas aeruginosa (9.8%). overall, the rates of extended-spectrum β-lactamase (e ... | 2017 | 28435019 |
| biofilm is a major virulence determinant in bacterial colonization of chronic skin ulcers independently from the multidrug resistant phenotype. | bacterial biofilm is a major factor in delayed wound healing and high levels of biofilm production have been repeatedly described in multidrug resistant organisms (mdros). nevertheless, a quantitative correlation between biofilm production and the profile of antimicrobial drug resistance in delayed wound healing remains to be determined. microbial identification, antibiotic susceptibility and biofilm production were assessed in 135 clinical isolates from 87 patients. gram-negative bacteria were ... | 2017 | 28513576 |
| bacterial bloodstream infections in a tertiary infectious diseases hospital in northern vietnam: aetiology, drug resistance, and treatment outcome. | bloodstream infections (bsis) are associated with high morbidity and mortality worldwide. however their aetiology, antimicrobial susceptibilities and associated outcomes differ between developed and developing countries. systematic data from vietnam are scarce. here we present aetiologic data on bsi in adults admitted to a large tertiary referral hospital for infectious diseases in hanoi, vietnam. | 2017 | 28701159 |
| synthesis and biological evaluation of indole core-based derivatives with potent antibacterial activity against resistant bacterial pathogens. | the emergence of drug resistance in bacterial pathogens is a growing clinical problem that poses difficult challenges in patient management. to exacerbate this problem, there is currently a serious lack of antibacterial agents that are designed to target extremely drug-resistant bacterial strains. here we describe the design, synthesis and antibacterial testing of a series of 40 novel indole core derivatives, which are predicated by molecular modeling to be potential glycosyltransferase inhibito ... | 2017 | 28465626 |
| copper complexes containing thiosemicarbazones derived from 6-nitropiperonal: antimicrobial and biophysical properties. | a series of four thiosemicarbazones from 6-nitropiperonal along with the corresponding copper complexes were synthesized. the biophysical characteristics of the complexes were investigated by the binding to dna and human serum albumin. the binding to dna is moderate; the binding constants run from (0.49-7.50)×10(4)m(-1). in relation to hsa, the complexes interact strongly with binding constants on the order of 10(5)m(-1). the complexes also display antioxidant behavior as determined by the abili ... | 2017 | 28448954 |
| evaluation of six phenotypic methods for the detection of carbapenemases in gram-negative bacteria with characterized resistance mechanisms. | we compared the performance of the modified hodge test (mht), triton hodge test (tht), carba np test (cnpt), simplified carba np test (cnpt-direct), blue-carba np test (bct), and carbapenem inactivation method (cim) for rapid and accurate carbapenemase detection. | 2017 | 28445009 |
| effectiveness of cleaning-disinfection wipes and sprays against multidrug-resistant outbreak strains. | hospital rooms play an important role in the transmission of several health care-associated pathogens. during the last few years, a number of innovative cleaning-disinfecting products have been brought to market. in this study, commercially available products combining cleaning and disinfection were compared, using 2 different application methods. the aim was to determine which product was most effective in simultaneous cleaning and disinfection of surfaces. | 2017 | 28571980 |
| differences in antimicrobial consumption, prescribing and isolation rate of multidrug resistant klebsiella pneumoniae, pseudomonas aeruginosa and acinetobacter baumannii on surgical and medical wards. | in order to provide guidance data for clinically rational use of an antibiotics consuption, prescribing and prevalence of multidrug resistant (mdr) klebsiella pneumoniae, pseudomonas aeruginosa and acinetobacter baumannii were monitored on the surgical (s) and medical (m) wards of the university hospital center "dr. dragisa misovic-dedinje" (belgrade, serbia), in the study period from 2012 to 2015. appropriateness of antimicrobial use was evaluated using the global-prevalence survey method desig ... | 2017 | 28467437 |
| simple and fast detection of resistance to antibiotic inhibitors of protein synthesis in gram-negative pathogens through evaluation of mitomycin c-induced cell elongation. | increasing the resistance of gram-negative pathogens to antibiotics that inhibit protein synthesis is of great concern. in life-threatening situations, an early detection of antibiotic resistance may improve patient outcome. a rapid assay for the identification of antibiotic resistance to gentamicin, tobramycin, and tigecycline has been designed and tested in clinical strains of acinetobacter baumannii, pseudomonas aeruginosa, and the enterobacteriaceae escherichia coli and klebsiella pneumoniae ... | 2017 | 28467172 |
| an unusual culprit: klebsiella pneumoniae causing septicaemia outbreaks in neonatal pigs? | this study investigated the cause of recent outbreaks of septicaemia in neonatal pigs in australia (victoria and queensland). septicaemia in neonatal pigs is commonly caused by enterotoxigenic e. coli, extraintestinal pathogenic e. coli and beta-haemolytic streptococci. infrequent causes of septicaemia are actinobacillus suis and citrobacter freundii. therefore, it was quite unexpected when klebsiella pneumoniae was isolated in predominant growth from multiple organs of pigs dying of septicaemia ... | 2017 | 28619154 |
| novel plasmid-mediated colistin resistance gene mcr-3 in escherichia coli. | the mobile colistin resistance gene mcr-1 has attracted global attention, as it heralds the breach of polymyxins, one of the last-resort antibiotics for the treatment of severe clinical infections caused by multidrug-resistant gram-negative bacteria. to date, six slightly different variants of mcr-1, and a second mobile colistin resistance gene, mcr-2, have been reported or annotated in the genbank database. here, we characterized a third mobile colistin resistance gene, mcr-3 the gene coexisted ... | 2017 | 28655818 |
| production, characterization, and antimicrobial activity of mycocin produced by debaryomyces hansenii dsmz70238. | the present study was conducted to estimate the antimicrobial activity and the potential biological control of the killer toxin produced by d. hansenii dsmz70238 against several pathogenic microorganisms. in this study, the effects of nacl, ph, and temperature, killer toxin production, and antimicrobial activity were studied. the results showed that the optimum inhibitory effect of killer toxin was at 8% nacl, and the diameters of clear zones were 20, 22, 22, 21, 14, and 13 mm for staphylococcus ... | 2017 | 28757872 |
| antimicrobial activity of endophytic bacterial populations isolated from medical plants of iran. | endophytic actinobacteria colonize inside the plant tissues without causing damages to the host plant. since these microorganisms colonize in the different parts of plants and can stop plant disease, they have been applied as biological agents for controlling human diseases. the aim of this study was molecular identification and measuring the antimicrobial activity of endophytic actinomycetes isolated from medicinal plants of iran. | 2017 | 28775818 |
| resistance profiles and risk factors of resistant microorganisms in bacteraemia of abdominal origin. | the presence of resistant microorganisms is a major cause of failure in initial empirical antimicrobial therapy. the objectives of this study are to determine the resistance profile of microorganisms that cause bacteraemia of abdominal origin and to identify whether the previous use of antibiotics and the place of acquisition of bacteraemia are risk factors associated with the presence of resistant organisms. | 2017 | 28434558 |
| time-kill kinetics and biocidal effect of euclea crispa leaf extracts against microbial membrane. | to evaluate antimicrobial potential of the fractions partitioned from euclea crispa leaf extract and determination of their impact on cell membrane disruption. | 2017 | 28552109 |
| evaluation of anthelmintic antimicrobial and antioxidant activity of chenopodium album. | the objective of this study was to evaluate the anthelmintic, antimicrobial and antioxidant activities of chenopodium album against gastrointestinal nematodes of sheep and some pathogenic microbes. a worm motility inhibition assay was used for in vitro study, and a faecal egg count reduction assay was used for an in vivo study. various concentrations ranging from 100 to 500 μg/ml of the extract were subjected to antimicrobial screening by disc diffusion method against four selected bacterial (st ... | 2017 | 28735356 |
| characteristics of meningitis following transsphenoidal endoscopic surgery: a case series and a systematic literature review. | meningitis occurs in 0.8-1.5% of patients undergoing neurosurgery. the aim of the study was to evaluate the characteristics of meningitis after endoscopic endonasal transsphenoidal surgery (eets) comparing the findings retrieved to those highlighted by literature search. | 2017 | 28776163 |
| investigation of antioxidant, antimicrobial and toxicity activities of lichens from high altitude regions of nepal. | several lichen species are reported to be used tradiationally in many theraupatic practices. many lichen species are reported as sources of several bioactive natural compounds. several lichen species of nepal are so far chemically unexplored. | 2017 | 28545438 |
| characterization of oxa-48-like-producing enterobacteriaceae isolated from river water in algeria. | the spread of carbapenemase-producing enterobacteriaceae (cpe) is a significant problem for healthcare worldwide. the prevalence of carbapenem-resistant enterobacteriaceae (cpe) in water environments in algeria are unknown. the aim of this study was to screen for the presence of cpe isolates in the soummam river in bejaia, algeria. isolates of enterobacteriaceae recovered from twelve samples of river water and showing reduced susceptibility to carbapenems were included in this study. the isolate ... | 2017 | 28486169 |
| isolation, morphological identification and in vitro antibacterial activity of endophytic bacteria isolated from azadirachta indica (neem) leaves. | the objective of this study was to isolate endophytic bacteria from azadirachta indica (neem) leaves, their identification and investigate their antibacterial activity against three gram-positive bacteria, staphylococcus aureus, streptococcus pyogenes and bacillus cereus and gram-negative bacteria escherichia coli, salmonella typhimurium and klebsiella pneumoniae. | 2017 | 28620254 |
| an enhancement of antimicrobial efficacy of biogenic and ceftriaxone-conjugated silver nanoparticles: green approach. | of the various methods explored for the synthesis of nanoparticles, biogenesis of silver nanoparticles (agnps) received great attention due to their versatile properties. in this report, daucus carota extract was used for the synthesis of agnps and ceftriaxone was conjugated with agnps to enhance their antimicrobial efficacy. the conjugated and unconjugated agnps were characterized by adopting uv-vis spectroscopy, ftir, afm, dls, and tem, which revealed the spr peak at 420 nm and spherical shape ... | 2017 | 28600792 |
| characterization of the complete nucleotide sequences of inca/c2 plasmids carrying in809-like integrons from enterobacteriaceae isolates of wildlife origin. | a total of 18 enterobacteriaceae (17 from gulls and 1 from a clinical sample) collected from australia, carrying inca/c plasmids with the imp-encoding in809-like integrons, were studied. seven plasmids, being representatives of different origins, plasmid sizes, replicon combinations, and resistance genes, were completely sequenced. plasmid pec158, identified in a clinical escherichia coli st752 isolate, showed extensive similarity to type 2 inca/c2 plasmids. pec158 carried none of the blacmy-2-l ... | 2017 | 28696228 |
| antimicrobial, modulatory and chemical analysis of the oil of croton limae. | croton sp. are plants with a well-reported antimicrobial activity. croton limae a.p. gomes, m.f. sales p.e. berry (euphorbiaceae), known as 'marmeleiro-prateado', is commonly used to manage abdominal pain in brazil. | 2017 | 28738715 |
| phosphate crosslinked pectin based dual responsive hydrogel networks and nanocomposites: development, swelling dynamics and drug release characteristics. | potential dual responsive hydrogel networks (ppad) are fabricated from pectin, poly((2-dimethylamino)ethyl methacrylate)) and phosphate crosslinker bis[2-methacryloyloxy] ethyl phosphate (bmep) by a simple free radical polymerization. these hydrogel networks are successfully utilized for encapsulation of an anti-cancer drug, 5-fluorouracil (5-fu) and also employed as versatile platforms for production of silver nanoparticles. fabricated hydrogel networks and silver nanocomposites were characteri ... | 2017 | 28576553 |
| paneth-cell-disruption-induced necrotizing enterocolitis in mice requires live bacteria and occurs independently of tlr4 signaling. | necrotizing enterocolitis (nec) remains a leading cause of morbidity and mortality in premature infants. both human surgical specimens and animal models suggest a potential involvement of paneth cells in nec pathogenesis. paneth cells play critical roles in epithelial homeostasis, innate immunity and host-microbial interactions. yet, the complex interplay between paneth cell disruption, epithelial barrier dysfunction and microbial-driven inflammation remains unclear in the immature intestine. in ... | 2017 | 28450472 |
| an assessment on the role of endophytic microbes in the therapeutic potential of fagonia indica. | natural products of animals, plants and microbes are potential source of important chemical compounds, with diverse applications including therapeutics. endophytic bacteria that are especially associated with medicinal plants presents a reservoir of therapeutic compounds. fagonia indica has been recently investigated by numerous researchers because of its striking therapeutic potential especially in cancer. it is also reported that endophytes play a vital role in the biosynthesis of various meta ... | 2017 | 28764775 |
| a prospective randomised trial of isolated pathogens of surgical site infections (ssi). | every surgical wound is colonized by bacteria, but only a small percentage displays symptoms of infection. the distribution of pathogens isolated in surgical site infections has not significantly changed over the last decades. staph. aureus, coag(-) staphylococci, enterococcus spp and e. coli are the main strains appearing. in addition, a continuously rising proportion of surgical site infections caused by resistant bacterial species (mrsa, c. albicans) has been reported. | 2017 | 28761643 |
| what the eyes don't see, the heart does grieve over. | a 71 year old peruvian woman presented with blurry vision and bilateral eye pain and had evidence of bilateral endophthalmitis on eye examination. her past medical history was notable for multiple abdominal surgeries within the preceding months, including an incarcerated inguinal hernia repair which required an ileostomy placement, and cholecystitis requiring cholecystostomy tube placement. over her multiple long hospitalizations, she developed bacteremia and fungemia on several occasions, with ... | 2017 | 28414678 |
| simultaneous detection of 13 key bacterial respiratory pathogens by combination of multiplex pcr and capillary electrophoresis. | lower respiratory tract infections continue to pose a significant threat to human health. it is important to accurately and rapidly detect respiratory bacteria. to compensate for the limits of current respiratory bacteria detection methods, we developed a combination of multiplex polymerase chain reaction (pcr) and capillary electrophoresis (mpce) assay to detect thirteen bacterial pathogens responsible for lower respiratory tract infections, including streptococcus pneumoniae, haemophilus influ ... | 2017 | 28807095 |
| igm-mediated autoimmune responses to oxidative specific epitopes, but not nitrosylated adducts, are significantly decreased in pregnancy: association with bacterial translocation, perinatal and lifetime major depression and the tryptophan catabolite (trycat) pathway. | immunoglubulin (ig)m responses directed to oxidative specific epitopes (oses) and nitric oxide (no)-adducts are significantly associated with major depression and physio-somatic symptoms. end of term serum igm responses to oses and no-adducts were assayed in pregnant women with (n = 24) and without prenatal depression (n = 25) as well as in 24 non-pregnant women. associations of igm/iga responses to gram-negative gut commensal bacteria (leaky gut index) and iga/igm responses to tryptophan catabo ... | 2017 | 28600633 |
| chemical and antimicrobial analyses of sideritis romana l. subsp. purpurea (tal. ex benth.) heywood, an endemic of the western balkan. | a comprehensive study on essential oil and different solvent extracts of sideritis romana l. subsp. purpurea (tal. ex benth.) heywood (lamiaceae) from montenegro is reported. the gas chromatography-mass spectrometry analysis of the essential oil revealed a total of 43 components with bicyclogermacrene (23.8%), germacrene d (8%), (e)-caryophyllene (7.9%) and spathulenol (5.5%) as the major ones. sesquiterpenoid group was found to be the most dominant one (64.8%), with 19.9% of the oxygenated form ... | 2017 | 28832536 |
| comparison of two whole-room uv-irradiation systems for enhanced disinfection of patient rooms contaminated with mrsa, carbapenemase-producing klebsiella pneumoniae and clostridium difficile spores. | ultraviolet light decontamination systems are being used increasingly to supplement terminal disinfection of patient rooms. however efficacy may not be consistent in the presence of soil particularly against clostridium difficile spores. | 2017 | 28823547 |
| the antimicrobial spectrum of xeroform(®). | xeroform(®) is a petrolatum-based fine mesh gauze containing 3% bismuth tribromophenate. bismuth, similar to other metals, has antimicrobial properties. xeroform(®) has been used for decades in burn and plastic surgery as a donor site dressing and as a covering for wounds or partial thickness burns. despite this, the antimicrobial spectrum of xeroform(®) remains largely unknown. we examined the in-vitro efficacy of xeroform(®) against common burn pathogens using zone-of-inhibition methodology in ... | 2017 | 28641915 |
| synthesis and evaluation of arylamidine derivatives for new antimicrobial and cytotoxic activities. | a series of arylamidines 3a-j was designed, synthesized and investigated for antimicrobial activity. structures of the compounds were confirmed by ir, 1h-nmr and 13c-nmr and a 2d spectroscopic study was performed. a preliminary screening of the antimicrobial tests clearly showed that three out of ten arylamidines, viz, 3f, 3g and 3i, were effective against all the gram-negative bacteria: klebsiella pneumoniae, pseudomonas aeruginosa and salmonella enteric; and against the yeast, candida albicans ... | 2017 | 28640352 |
| association between pathogens from tracheal aspirate and oral biofilm of patients on mechanical ventilation. | the aim of this study was to detect possible associations between respiratory pathogens from tracheal aspirate and oral biofilm samples in intubated patients in an intensive care unit (icu), and to identify the most common respiratory pathogens in oral biofilm, particularly in patients that developed ventilator-associated pneumonia (vap). two oral biofilm samples were collected from the tongue of intubated patients (at admission and after 48 hours) and analyzed by culture with the antibiotic sen ... | 2017 | 28591237 |
| in vitro antimicrobial potential of extracts and phytoconstituents from gymnema sylvestre r.br. leaves and their biosafety evaluation. | the in vitro antimicrobial screening of gymnema sylvestre leaves against 13 test pathogens established its broad spectrum activity with average inhibition zone ranging from 14 to 23 mm. the antimicrobial activity of the classically- optimized aqueous extract was enhanced up to 1.45 folds, when subjected to statistical optimization using response surface methodology (rsm) and was thermostable. ethyl acetate was found to be the best organic extractant with klebsiella pneumoniae 1 (31.5 mm) and sta ... | 2017 | 28587443 |
| investigation of effect of 1,8-cineole on antimicrobial activity of chlorhexidine gluconate. | chlorhexidine belongs to a group of medicines called antiseptic antibacterial agents. chlorhexidine is commonly used for the care and clean off the skin, hands, and wounds. in recent years, medicinal and aromatic plants have been used for prevention of disease, maintaining health, and improving disease in traditional and modern medicine as a medicament. according to recent research, cineole is the isolated active agent of eucalyptus oil and possesses antimicrobial activity. it was demonstrated t ... | 2017 | 28827963 |
| enhanced larvicidal, antibacterial, and photocatalytic efficacy of tio2 nanohybrids green synthesized using the aqueous leaf extract of parthenium hysterophorus. | titanium dioxide nanoparticles are emerging as a biocompatible nanomaterial with multipurpose bioactivities. in this study, titanium dioxide (tio2) nanoparticles were effectively synthesized using the aqueous leaf extracts of parthenium hysterophorus prepared by microwave irradiation. tio2 nanoparticles were fabricated by treating the p. hysterophorus leaf extracts with the tio4 solution. biologically active compounds such as alcohols, phenols, alkanes, and fluoroalkanes were involved in bioredu ... | 2017 | 28537028 |
| characterization of the polymyxin d synthetase biosynthetic cluster and product profile of paenibacillus polymyxa atcc 10401. | the increasing prevalence of polymyxin-resistant bacteria has stimulated the search for improved polymyxin lipopeptides. here we describe the sequence and product profile for polymyxin d nonribosomal peptide synthetase from paenibacillus polymyxa atcc 10401. the polymyxin d synthase gene cluster comprised five genes that encoded abc transporters (pmxc and pmxd) and enzymes responsible for the biosynthesis of polymyxin d (pmxa, pmxb, and pmxe). unlike polymyxins b and e, polymyxin d contains d-se ... | 2017 | 28463513 |
| the use of bloodstream infection mortality to measure the impact of antimicrobial stewardship interventions: assessing the evidence. | this review sets out to evaluate the current evidence on the impact of inappropriate therapy on bloodstream infections (bsi) and associated mortality. based on the premise that better prescribing practices should result in better patient outcomes, bsi mortality may be a useful metric to evaluate antimicrobial stewardship (ams) interventions. a systematic search was performed in key medical databases to identify papers published in english between 2005 and 2015 that examined the association betwe ... | 2017 | 28458799 |
| structure, genetics and worldwide spread of new delhi metallo-β-lactamase (ndm): a threat to public health. | the emergence of carbapenemase producing bacteria, especially new delhi metallo-β-lactamase (ndm-1) and its variants, worldwide, has raised amajor public health concern. ndm-1 hydrolyzes a wide range of β-lactam antibiotics, including carbapenems, which are the last resort of antibiotics for the treatment of infections caused by resistant strain of bacteria. | 2017 | 28449650 |
| [to the state of the fetoplacental complex in women with the threat of abortion]. | the goal is a comprehensive study of the morphofunctional state of the mother-placenta-fetus system in placental insufficiency and infection. 250 pregnant and puerperas for the period 2008-2014 were examined. detection of bacterial flora was carried out in 35 pregnant women aged 20.4±0.8 years with the threat of abortion from an early gestation period and a prolonged persistent infection of the genitals, bacterial vaginosis. methods are applied: culture, ion chromatography, gas-liquid chromatogr ... | 2017 | 28820412 |
| risk factors and predictors of mortality of candidaemia among critically ill patients: role of antifungal prophylaxis in its development and in selection of non-albicans species. | the aim of the present study is to identify risk factors for development and predictors of mortality of candidaemia among critically ill patients. | 2017 | 28756598 |
| relative susceptibility of airway organisms to antimicrobial effects of nitric oxide. | nitric oxide (no) is released in the airway as a critical component of innate immune defense against invading pathogenic organisms. it is well documented that bacteriostatic and bactericidal effects of no are concentration-dependent. however, few data exist comparing relative susceptibility of common pathogens to no at physiologic concentrations. in this study we evaluated the effects of no on 4 common airway bacteria and 1 fungus, and examined the potential implications of discrepancies in sens ... | 2017 | 28544570 |
| microbiological analysis of acute infections of the nail fold on the basis of bait thread test. | an acute infection of the nail fold, called paronychia, is a common clinical problem. the basis for the implementation of the treatment is the result of microbiological examination. due to the rapid and painful course of infection, usually an empirical antimicrobial treatment prior to obtaining microbiological test results is introduced. | 2017 | 28507488 |
| synthesis, characterization, antimicrobial and antiproliferative activity evaluation of cu(ii), co(ii), zn(ii), ni(ii) and pt(ii) complexes with isoniazid-derived compound. | hydrazone complexes of cu(ii), co(ii), zn(ii), ni(ii) and pt(ii) with n-isonicotinoyl-n'-(3-metoxy-2 hydroxybenzaldehyde)-hydrazone (hl) were synthesized and characterized by different physico-chemical techniques including elemental and thermal analysis, magnetic susceptibility measurements, molar electric conductivity, as well as ir (infrared), ¹h-nmr and (13)c-nmr (hydrogen and carbon nuclear magnetic resonance, uv-vis (ultraviolet-visible), fab (fast atom bombardment), epr (electron paramagne ... | 2017 | 28422067 |
| assessment of herbal drugs for promising anti-candida activity. | microbial infections are diverse and cause serious human diseases. candida albicans infections are serious healthcare-related infections that are complicated by its morphological switching from yeast to hyphae, resistant biofilm formation and mixed infections with bacteria. due to the increase in drug resistance to currently used antimicrobial agents and the presence of undesirable side effects, the need for safe and effective novel therapies is important. compounds derived from plants are known ... | 2017 | 28482836 |
| the occurrence of ctx-m-25-producing enterobacteriaceae in day-old broiler chicks in japan. | day-old chicks from 3 hatcheries were placed on bedding paper and brought to a commercial broiler farm between january and july 2016. sixty-six samples of the paper, which were stained with meconium droppings of the chicks, were collected and examined for isolation of cephalosporin-resistant enterobacteriaceae. cefotaxime (ctx)-resistant klebsiella pneumoniae (1 isolate) and enterobacter cloacae (4 isolates) were isolated from 5 (7.58%) of the 66 samples. conjugation experiments revealed that th ... | 2017 | 28781343 |
| wastewater is a reservoir for clinically relevant carbapenemase- and 16s rrna methylase-producing enterobacteriaceae. | the aim of this study was to evaluate wastewater for carbapenemase-producing enterobacteriaceae (cpe) and 16s rrna methylase-producing gram-negative bacteria (mpb) and to assess their occurrence following wastewater treatment. wastewater samples were collected between june 2015 and march 2016 in the sewage network of the city of basel (switzerland) from sites located before and after influx of wastewater from the hospital into the sewage network. samples were also obtained from the influent and ... | 2017 | 28668692 |
| genomic and phenotypic characterisation of fluoroquinolone resistance mechanisms in enterobacteriaceae in durban, south africa. | resistance to fluoroquinolones (fq) is being increasingly reported and found to be mediated by efflux pumps, plasmid-mediated quinolone resistance genes (pmqr) and mutations in gyra, gyrb, parc and pare. however, studies reporting on fq resistance mechanisms (fqrm), particularly in africa, are focused mostly on salmonella. this study used a whole-genome-based approach to describe fqrm in forty-eight clinical enterobacteriaceae isolates comprising of klebsiella pneumoniae (n = 21), serratia marce ... | 2017 | 28636609 |
| the bactericidal effect of simultaneous titanium oxide on common hospital bacteria. | bacteria prevalence has increased in health centers and hospitals. infection control can decrease the number of bacteria. bacteria cause 90% of nosocomial infections and fungi, viruses, or protozoa are less involved. bacteria control can decrease the number of diseases. the simultaneous titanium oxide (smtio) is a new method of disinfection. this process degrades bacteria by producing hydroxyl radical. the present study was conducted with the aim of analyzing the bactericidal effect of simultane ... | 2017 | 28623574 |
| impact of a mixed educational and semi-restrictive antimicrobial stewardship project in a large teaching hospital in northern italy. | the overuse of antimicrobials favors the dissemination of antimicrobial resistance, as well as invasive fungal diseases and clostridium difficile infections (cdi). in this study, we assessed the impact of a mixed educational and semi-restrictive antimicrobial stewardship (ams) project in a large teaching hospital in italy. | 2017 | 28856589 |
| response to letter of k. singh, 'role of silver nitrate in the efficacy of hydrogen peroxide aerial decontamination systems' regarding s. ali et al. 'efficacy of two hydrogen peroxide vapour aerial decontamination systems for enhanced disinfection of meticillin-resistant staphylococcus aureus, klebsiella pneumoniae and clostridium difficile in single isolation rooms'. | 2017 | 28734723 | |
| the influence of maternal vaginal flora on the intestinal colonization in newborns and 3-month-old infants. | the role of maternal vaginal bacteria on the colonization of neonatal gut is still a matter of discussion. our aim was to estimate the role of maternal vaginal flora on the development of intestinal flora in neonates and 3-month-old infants. | 2017 | 28420276 |
| colonization by multidrug-resistant organisms in long-term care facilities in italy: a point-prevalence study. | to determine prevalence and risk factors for colonization by multidrug-resistant organisms (mdros) in long-term care facility (ltcf) residents in italy. genotypes of mdro isolates were investigated. | 2017 | 28412380 |
| conformational control of udp-galactopyranose mutase inhibition. | udp-galactopyranose mutase (glf or ugm) catalyzes the formation of uridine 5'-diphosphate-α-d-galactofuranose (udp-galf) from udp-galactopyranose (udp-galp). the enzyme is required for the production of galf-containing glycans. ugm is absent in mammals, but members of the corynebacterineae suborder require ugm for cell envelope biosynthesis. the need for ugm in some pathogens has prompted the search for inhibitors that could serve as antibiotic leads. optimizing inhibitor potency, however, has b ... | 2017 | 28608671 |
| allodemic distribution of plasmids co-harbouring blactx-m-15/aac(6')-ib-cr/qnrb in klebsiella pneumoniae is the main source of extended-spectrum β-lactamases in uruguay's paediatric hospital. | this study aimed to describe the characteristics of clinical isolates of extended-spectrum β-lactamase (esbl)-producing enterobacteria (epe) in uruguay's paediatric hospital. | 2017 | 28419869 |
| carbapenem-resistant enterobacter cloacae in patients from the us veterans health administration, 2006-2015. | we analyzed carbapenem-resistant enterobacteriaceae (cre) trends among patients from the us veterans health administration (vha). after the emergence of cre in the eastern united states, resistance rates remained stable in klebsiella pneumoniae but increased in enterobacter cloacae complex, suggesting a "second epidemic". vha offers a vantage point for monitoring nationwide cre trends. | 2017 | 28418318 |
| oxa-48-like carbapenemases in the uk: an analysis of isolates and cases from 2007 to 2014. | oxa-48-like carbapenemases have spread worldwide since 2001. we analysed patient and microbiological data for uk isolates with these enzymes as confirmed by the national reference laboratory from november 2007 to december 2014. | 2017 | 28199647 |
| factors associated with carriage of carbapenem-non-susceptible enterobacteriaceaein north-eastern france and outcomes of infected patients. | carbapenems are frequently used as a last resort to treat infections caused by multidrug-resistant gram-negative organisms, thus carbapenem-non-susceptible enterobacteriaceae (cnse) is an emerging health threat. | 2017 | 28158526 |
| the clear and present danger of carbapenemase-producing enterobacteriaceae (cpe) in new zealand: time for a national response plan. | antimicrobial resistance (amr) in general poses a threat to the sustainability of modern healthcare, but a particularly urgent and serious threat is posed by a specific group of antibiotic-resistant bacteria known as carbapenemase-producing enterobacteriaceae (cpe). cpe are resistant to nearly all antibiotics and include common pathogens such as escherichia coli and klebsiella pneumoniae. in new zealand, the incidence of cpe has increased from three isolates in 2012 to 45 in 2016. the current ep ... | 2017 | 28449019 |
| rapid phenotypic stress-based microfluidic antibiotic susceptibility testing of gram-negative clinical isolates. | bacteremia is a life-threatening condition for which antibiotics must be prescribed within hours of clinical diagnosis. since the current gold standard for bacteremia diagnosis is based on conventional methods developed in the mid-1800s-growth on agar or in broth-identification and susceptibility profiling for both gram-positive and gram-negative bacterial species requires at least 48-72 h. recent advancements in accelerated phenotypic antibiotic susceptibility testing have centered on the micro ... | 2017 | 28808348 |
| the first enterobacter cloacae co-producing ndm and oxa-48 carbapenemases and interhospital spread of oxa-48 and ndm-producing klebsiella pneumoniae in turkey. | the aim of this study was to investigate the occurrence of carbapenemase-producing enterobacteriaceae. | 2017 | 28792697 |
| extended-spectrum β-lactamases and plasmid-mediated quinolone resistance in enterobacterial clinical isolates from neonates in tunisia. | this study was conducted to investigate extended-spectrum-β-lactamase (esbl) producing enterobacteriaceae isolates from the center of maternity and neonatology of monastir, tunisia. fourty-six strains out of 283 were found to produce esbl: klebsiella pneumoniae (n = 37), escherichia coli (n = 6), enterobacter cloacae (n = 2), and citrobacter freundi (n = 1). genotyping analysis, using eric2 and rapd, showed that strains were clonally unrelated. pcr amplification followed by sequencing revealed t ... | 2017 | 28648624 |
| molecular and microbiological report of a hospital outbreak of ndm-1-carrying enterobacteriaceae in mexico. | to characterize the microbiological, molecular and epidemiological data of an outbreak of carbapenem-resistant enterobacteriaceae (cre) in a tertiary-care hospital in mexico. | 2017 | 28636666 |
| dissemination of bla oxa-370 gene among several enterobacteriaceae species in brazil. | oxa-370 is a recently described oxa-48 variant that has only been described in a few enterobacter spp. and klebsiella pneumoniae isolates. the purpose of this study is to assess the prevalence of oxa-370-producing isolates in carbapenem-nonsusceptible enterobacteriaceae recovered from 28 hospitals from brazil. real-time pcr was used to determine the presence of bla ndm-1, bla kpc-2, bla vim-type, bla ges-type, bla oxa-48-like, and bla imp-type genes. a total of 4,451 enterobacteriaceae were scre ... | 2017 | 28555403 |
| sequencing of blaimp-carrying incn2 plasmids, and comparative genomics of incn2 plasmids harboring class 1 integrons. | this work presents the complete nucleotide sequences of p0801-imp from klebsiella pneumoniae, p7121-imp from k. oxytoca, and p17285-imp from citrobacter freundii, which are recovered from three different cases of nosocomial infection. these three plasmids represent the first fully sequenced blaimp-carrying incn2 plasmids. further comparative genomics analysis of all the five integron-carrying incn2 plasmids p0801-imp, p7121-imp, p17285-imp, pjie137, and p34983-59.134kb indicates that they posses ... | 2017 | 28424761 |