PMID(sorted ascending)
cultural and biochemical characteristics of the genus chromobacterium. 195613357716
the change from polar to peritrichous flagellation in chromobacterium spp. 195613357717
pseudohaemoptysis due to chromobacterium prodigiosum. 195713417607
the isolation of d-glycero-d-galactoheptose and other sugar components from the specific polysaccharide of chromobacterium violaceum (bn). 195713459897
[classification of pseudomonadaceae]. 195713470460
[chromobacteria in human pathology; human chromobacterium infections]. 195813543121
a water-soluble, diffusible pigment produced by a strain of serratia marcescens (chromobacterium prodigiosum). 195813590216
[culture of bacteria by symbiotic procedure with a new form of metagenetic plate. i]. 195813595734
[culture of bacteria by symbiotic procedure with a new form of metagenetic plate. ii]. 195813595735
the isolation of d-fucosamine from the specific polysaccharide of chromobacterium violaceum (nctc 7917). 195813607435
production of hemolysis by chromobacterium violaceum. 195913626901
nutritional requirements of chromobacterium violaceum. 195913630861
isolation of chromobacterium prodigiosum from empyema. 195913641437
particulate-bound pigment of serratia marcescens (chromobacterium prodigiosum). 195913652969
the serology and pathogenicity of the genus chromobacterium. 195913654734
accumulation of indole compounds in cultures of chromobacterium violaceum. 196113695636
a pigment-producing spoilage bacterium responsible for violet discoloration of refrigerated market milk and cream.a psychrophilic strain of bacteria identified as chromobacterium lividum was established as the causative agent of an outbreak of violet discoloration in refrigerated, pasteurized retail milk and cream. the organism was rod-shaped, gram-negative, and produced viscid colonies with abundant violet pigment on tryptone glucose yeast extract agar. growth was abundant at 4 c but none occurred at 37 c. growth in milk was characterized by a dark violet ring at the surface after a few days, and the deep ...196113749823
infection due to chromobacteria. report of a case of pneumonia due to chromobacterium prodigiosum successfully treated with kanamycin. 196013799665
the extracellular polysaccharide of gelatinous strains of chromobacterium violaceum. 196013812063
incorporation of c14-labeled substrates into violacein. 196013815862
physiological aspects of violacein biosynthesis in nonproliferating cells. 195913815863
[studies on the formation of volatile acids by microorganisms from the family of achromobacter. pseudomonas and chromobacterium by means of paper chromatography]. 195913851129
isolation of guanosine 2',3'-cyclic phosphate from chromobacterium violaceum. 196213898776
divergent pathways of indole metabolism in chromobacterium violaceum. 196213987555
intracellular nucleotides isolated from chromobacterium violaceum. 196213989398
isolation of a new amino sugar from chromobacterium violaceum.smith, e. j. (duke university, durham, n.c.), j. m. leatherwood, and r. w. wheat. isolation of a new amino sugar from chromobacterium violaceum. j. bacteriol. 84:1007-1010. 1962.-an investigation of the amino sugars and reducing compounds of a lipopolysaccharide of chromobacterium violaceum revealed the presence of a previously unreported cationic reducing compound. evidence indicates that the compound is a 6-deoxyhexosamine with an amino group at other than the c-2 position.196213989399
studies on the cell wall of chromobacterium violaceum: the separation of lipopolysaccharide and mucopeptide by phenol extraction of whole cells. 196314000218
characterization of a 4-amino-4:6-dideoxy aldohexose from chromobacterium violaceum. 196214000219
peroxides and mutations. 196314002158
[apropos of the use of sodium gluatmate in lyophilization of bacteria]. 196314020341
extracellular accumulation of pyrroles in bacterial cultures.aerobacter aerogenes, paracolobactrum aerogenoides, spirillum serpens, and gelatinous strains of chromobacterium violaceum produced an extracellular, ether-soluble, ehrlich-positive substance when grown in media prepared with gelatin hydrolysate. the substance has been tentatively identified as pyrrole-2-carboxylic acid. both hydroxy-l-proline and allo-d-hydroxyproline have been shown to be precursors of the material. gelatinous strains of chromobacterium violaceum, but not the other positive cu ...196314023126
decomposition and binding action of a polysaccharide from chromobacterium violacium in soil.martin, j. p. (university of california, riverside) and s. j. richards. decomposition and binding action of a polysaccharide from chromobacterium violaceum in soil. j. bacteriol. 85:1288-1294. 1963.-the decomposition rate and binding effect in soil of a polysaccharide from chromobacterium violaceum was compared with that of a variety of bacterial and plant polysaccharides and more complex organic residues. most of the polysaccharides tested decomposed more readily than mature plant residues and ...196314047219
modification of host responses to bacterial endotoxins. i. specificity of pyrogenic tolerance and the role of hypersensitivity in pyrogenicity, lethality, and skin reactivity.evidence is presented suggesting that the apparent non-specificity of pyrogenic tolerance observed with gram-negative bacterial endotoxins is due to related antigenic determinants associated with the macromolecular toxins. this is based on results obtained in rabbits from pyrogenic cross-tolerance tests with selected endotoxins. in these tests, purified endotoxins from escherichia coli (coo8) and chromobacterium violaceum (cv) gave results one might expect with non-reciprocal cross-reacting anti ...196314078002
some applications of deoxyribonucleic acid base composition in bacterial taxonomy. 196314108436
urease activity of intact and disrupted bacteria. 196414120692
infection and the water-closet. 196414133601
isolation of d-fucosamine from bacillus cereus. 196414167834
[comparative evaluation of the effectiveness of bacteria-trapping devices in the determination of bacterial concentrations of aerosols]. 196314187229
the synthesis of n-acetyl-alpha-and n-acetyl-beta-d-glucosamine i-phosphates (2-acetamido-2-deoxy-alpha- and beta-d-glucose i-phosphates). 196414192914
a humoral antibody associated with endotoxin resistance. 196414200101
6-hydroxytryptophan formation by chromobacterium violaceum. 196414206055
the effects of selected strains of pigmented microorganisms on small free-living amoebae. 196414206897
[a comparative study of the nuclease activity of various species of saprophytic bacteria]. 196414208279
effect of mutation on dna-composition of some bacteria. 196414218440
factors influencing growth and polysaccharide formation by strains of chromobacterium violaceum.corpe, william a. (columbia university, new york, n.y.). factors influencing growth and polysaccharide formation by strains of chromobacterium violaceum. j. bacteriol. 88:1433-1441. 1964.-gelatinous chromobacterium violaceum strains elaborate a fibrous exopolysaccharide that forms a matrix in which growing cells are embedded. stable, nongelatinous variants arising from gelatinous cultures were of two types: (i) those that had lost the ability to produce polysaccharide, and (ii) those that had lo ...196414234803
[results of a 7 years survey on enterobacteriaceae from butcher's meat in dalat and surroundings (central vietnam)]. 196414250522
cyanide formation by chromobacterium violaceum.michaels, ruth (columbia university, new york, n.y.), and w. a. corpe. cyanide formation by chromobacterium violaceum. j. bacteriol. 89:106-112. 1965.-the formation of cyanide by a chromobacterium violaceum strain was studied with growing cultures and with nonproliferating cells grown in complex and chemically defined media. most of the cyanide was produced during the log-phase growth of the organism, and accumulated in the culture supernatant fluid. a synergistic effect of glycine and methionin ...196514255648
[immunochemical analysis of protein fractions of chromogenic (yellow) bacteria isolated from the blood of paratyphoid patients]. 196414263623
immunological properties of bacterial cell wall mucopeptides. 196514268620
[pathogenicity of serratia marcescens or chromobacterium prodigiosum]. 196414292685
formation of 5-hydroxytryptophan from tryptophan by chromobacterium violaceum. 195514394084
association of pigment with the cell envelope of serratia marcescens (chromobacterium prodigiosum). 196014435346
[isolation of chromobacterium prodigiosum in a case of chronic atypical pneumonia]. 196114473317
the complete genome sequence of chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability.chromobacterium violaceum is one of millions of species of free-living microorganisms that populate the soil and water in the extant areas of tropical biodiversity around the world. its complete genome sequence reveals (i) extensive alternative pathways for energy generation, (ii) approximately 500 orfs for transport-related proteins, (iii) complex and extensive systems for stress adaptation and motility, and (iv) widespread utilization of quorum sensing for control of inducible systems, all of ...200314500782
improvement in enzyme activity and stability by addition of low molecular weight polyethylene glycol to sodium bis(2-ethyl-l-hexyl)sulfosuccinate/isooctane reverse micellar system.the activity and stability of chromobacterium viscosum lipase (glycerolester hydrolase, ec olive oil hydrolysis in sodium bis (2-ethyl-l-hexyl)sulfosuccinate (aot)/isooctane reverse micelles is increased appreciably when low molecular weight polyethylene glycol (peg 400) is added to the reverse micelles. to understand the effect of peg 400 on the phase behavior of the reverse micellar system, the phase diagram of aot/ peg 400/water/isooctane system was studied. the influences ...200314515025
production of acylated homoserine lactones by different serotypes of vibrio anguillarum both in culture and during infection of rainbow trout.onehundred and forty-eight out of onehundred and fifty strains of vibrio anguillarum isolated from vibriosis in danish marine aquaculture produced bacterial communication signals, acylated homoserine lactones, eliciting a response in the agrobacterium tumefaciens (pzlr4) monitoring system. one strain, a serotype o4, induced a strong response in the chromobacterium violaceum (cv026) monitoring system. profiles of ahls determined by tlc separation revealed the presence of at least four ahls and a ...200314529176
cytotoxicity and potential antiviral evaluation of violacein produced by chromobacterium violaceum.natural products are an inexhaustible source of compounds with promising pharmacological activities including antiviral action. violacein, the major pigment produced by chromobacterium violaceum, has been shown to have antibiotic, antitumoral and anti-trypanosoma cruzi activities. the goal of the present work was to evaluate the cytotoxicity of violacein and also its potential antiviral properties. the cytotoxicity of violacein was investigated by three methods: cell morphology evaluation by inv ...200314595466
lipase-catalyzed kinetic resolution on solid-phase via a "capture and release" strategy.the lipase-catalyzed kinetic resolution of (r/s)-3-phenylbutyric acid 2 using solid-supported cyclohexane-1,3-dione (chd) 6 is described. in each case the predominant enantiomer observed, after cleavage from the resin, was (r)-(-)-3-phenylbutyric acid (r)-2 (ee > 99%) rather than the expected (s)-enantiomer of 2. this observation is in contrast to the fact that chromobacterium viscosum lipase shows high enantiospecificity for the (s)-enantiomer in the corresponding solution-phase hydrolysis reac ...200314611219
microbial genomics: tropical treasure?a brazilian consortium has unveiled the genomic dna sequence of the purple-pigmented bacterium chromobacterium violaceum, a dominant component of the tropical soil microbiota. the sequence provides insight into the abundant potential of this organism for biotechnological and pharmaceutical applications.200414738751
characterisation of steryl esterase activities in commercial lipase preparations.triglycerides, steryl esters, resin acids, free fatty acids and sterols are lipophilic extractives of wood (commonly referred to as pitch or wood resin) and have a negative impact on paper machine runnability and quality of paper. thus, enzymes capable of modifying these compounds would be potential tools for reducing pitch problems during paper manufacture. in this work, 19 commercial lipase preparations were tested for their ability to degrade steryl esters, which may play a significant role i ...200414741769
toward pku enzyme replacement therapy: pegylation with activity retention for three forms of recombinant phenylalanine hydroxylase.phenylketonuria (pku) is a disease in which phenylalanine and phenylalanine-derived metabolites build up to neurotoxic levels due to mutations in the phenylalanine hydroxylase gene (pah). enzyme replacement therapy is a viable option to supply active pah. however, the inherent protease sensitivity and potential immunogenicity of pah have precluded adoption of this approach. in this report, we have used polyethylene glycol derivatization (pegylation) to produce protected forms of pah for potentia ...200414741785
infection due to chromobacteria; report of 11 cases. 195114867953
infection due to chromobacteria. 195114880467
a study of the wide spread distribution of chromobacterium species in soil by a simple technique. 195114897823
chromobacterial infection in man. 195214932538
a new method of synthesis and antibacterial activity evaluation of piper amides.several natural piper amides and their mimics were synthesized by developing a new strategy of amide formation. the piper amides were tested against both gram +ve and gram -ve bacterial strains and found that they are particularly more active against staphylococcus aureus and chromobacterium violaceum strains.200414974622
role of the second coordination sphere residue tyrosine 179 in substrate affinity and catalytic activity of phenylalanine hydroxylase.phenylalanine hydroxylase converts phenylalanine to tyrosine utilizing molecular oxygen and tetrahydropterin as a cofactor, and belongs to the aromatic amino acid hydroxylases family. the catalytic domains of these enzymes are structurally similar. according to recent crystallographic studies, residue tyr179 in chromobacterium violaceum phenylalanine hydroxylase is located in the active site and its hydroxyl oxygen is 5.1 a from the iron, where it has been suggested to play a role in positioning ...200414999516
impact of violacein-producing bacteria on survival and feeding of bacterivorous nanoflagellates.we studied the role of bacterial secondary metabolites in the context of grazing protection against protozoans. a model system was used to examine the impact of violacein-producing bacteria on feeding rates, growth, and survival of three common bacterivorous nanoflagellates. freshwater isolates of janthinobacterium lividum and chromobacterium violaceum produced the purple pigment violacein and exhibited acute toxicity to the nanoflagellates tested. high-resolution video microscopy revealed that ...200415006783
pathogenomics of non-pathogens.analysing the genomes of non-pathogenic microorganisms, in addition to its basic and applied scientific interest, can also shed considerable light on the study of pathogenic microorganisms. two of the three microorganisms described here are rarely pathogenic, but carry genetic determinants that have previously been identified as being important for the pathogenicity of other microorganisms. this underlines the growing understanding that many so-called 'virulence genes' are probably involved in m ...200415040257
production of n-acylhomoserine lactone signal molecules by gram-negative soil-borne and plant-associated bacteria.quorum-sensing control mediated by n-acylhomoserine lactone (ahl) signal molecules has been established as a key feature in the regulation of various metabolic traits in many bacteria. approximately 300 strains representing 6 genera and 18 species of soil-borne and plant-associated gram-negative bacteria isolated in various regions of the former ussr using two reporter systems were screened for ahl production. the production was observed in 17.5% of the screened bacterial strains. positive respo ...200315058194
a new set of bioinformatics tools for genome projects.a new tool called system for automated bacterial integrated annotation--sabia (sabia being a very well-known bird in brazil) was developed for the assembly and annotation of bacterial genomes. this system performs automatic tasks of assembly analysis, orfs identification/analysis, and extragenic region analyses. genome assembly and contig automatic annotation data are also available in the same working environment. the system integrates several public domains and newly developed software program ...200415100986
closure of rrna related gaps in the chromobacterium violaceum genome with the pcr-assisted contig extension (pace) the finishing phase of the chromobacterium violaceum genome project, the shotgun sequences were assembled into 57 contigs that were then organized into 19 scaffolds, using the information from shotgun and cosmid clones. among the 38 ends resulting from the 19 scaffolds, 10 ended with sequences corresponding to rrna genes (seven ended with the 5s rrna gene and three ended with the 16s rrna gene). the 28 non-ribosomal ends were extended using the pcr-assisted contig extension (pace) methodology ...200415100987
gene expression in chromobacterium violaceum.the repertoire of 4,431 open reading frames (orfs), eight rrna operons and 98 trna genes of chromobacterium violaceum must be expressed in a regulated manner for successful adaptation to a wide variety of environmental conditions. to accomplish this feat, the organism relies on protein machineries involved in transcription, rna processing and translation. analysis of the c. violaceum genome showed that transcription initiation, elongation and termination are performed by the five well-known rna ...200415100988
bacteriophages and insertion sequences of chromobacterium violaceum atcc 12472.a fluid genome is a great advantage to prokaryotes, enabling quick adaptation to various types of ecological niches and to diverse environmental selective pressures. a substantial portion of these sudden changes is mediated by lateral gene transfer (lgt), through genetic recombination mechanisms, such as transformation, conjugation and transduction. the recent sequencing of several organisms has offered a new approach to the study of lgt, using comparison and analysis of nucleotide sequences dis ...200415100989
genetic analysis of violacein biosynthesis by chromobacterium violaceum.chromobacterium violaceum presents a distinctive phenotypic characteristic, the production of a deep violet pigment named violacein. although the physiological function of this pigment is not well understood, the sequencing of the genome of this bacterium has given some insight into the mechanisms and control of violacein production. it was found that erythrose-4-phosphate (e4p), a precursor to aromatic amino acid biosynthesis, is produced by the non-oxidative portion of the hexose monophosphate ...200415100990
chemotaxis and flagellar genes of chromobacterium violaceum.the availability of the complete genome of the gram-negative beta-proteobacterium chromobacterium violaceum has increasingly impacted our understanding of this microorganism. this review focuses on the genomic organization and structural analysis of the deduced proteins of the chemosensory adaptation system of c. violaceum. c. violaceum has multiple homologues of most chemotaxis genes, organized mostly in clusters in the bacterial genome. we found at least 67 genes, distributed in 10 gene cluste ...200415100991
tolerance to stress and environmental adaptability of chromobacterium violaceum.chromobacterium violaceum is a gram-negative bacterium, abundant in a variety of ecosystems in tropical and subtropical regions, including the water and borders of the negro river, a major component of the amazon basin. as a free-living microorganism, c. violaceum is exposed to a series of variable conditions, such as different sources and abundance of nutrients, changes in temperature and ph, toxic compounds and uv rays. these variations, and the wide range of environments, require great adapta ...200415100992
transport genes of chromobacterium violaceum: an overview.the complete genome sequence of the free-living bacterium chromobacterium violaceum has been determined by a consortium of laboratories in brazil. almost 500 open reading frames (orfs) coding for transport-related membrane proteins were identified in c. violaceum, which represents 11% of all genes found. the main class of transporter proteins is the primary active transporters (212 orfs), followed by electrochemical potential-driven transporters (154 orfs) and channels/pores (62 orfs). other cla ...200415100993
drug resistance in chromobacterium violaceum.chromobacterium violaceum is a free-living bacterium commonly found in aquatic habitats of tropical and subtropical regions of the world. this bacterium is able to produce a large variety of products of biotechnological and pharmacological use. although c. violaceum is considered to be non-pathogenic, some cases of severe infections in humans and other animals have been reported. genomic data on the type strain atcc 12472(t) has provided a comprehensive basis for detailed studies of pathogenicit ...200415100994
chromobacterium violaceum genome: molecular mechanisms associated with pathogenicity.chromobacterium violaceum is a versatile, gram-negative beta-protebacterium that grows in a variety of ecosystems in tropical and subtropical areas, such as the water and borders of the negro river, in the amazon region of brazil. although it is a saprophyte and is generally considered non-pathogenic, sporadic cases of human infection have been described, mainly in young children and in immunodeficient individuals. although rare, infections with c. violaceum are characterized by rapid disseminat ...200415100995
energetic metabolism of chromobacterium violaceum.chromobacterium violaceum is a free-living microorganism, normally exposed to diverse environmental conditions; it has a versatile energy-generating metabolism. this bacterium is capable of exploiting a wide range of energy resources by using appropriate oxidases and reductases. this allows c. violaceum to live in both aerobic and anaerobic conditions. in aerobic conditions, c. violaceum is able to grow in a minimal medium with simple sugars, such as glucose, fructose, galactose, and ribose; bot ...200415100996
dna repair in chromobacterium violaceum.chromobacterium violaceum is a gram-negative beta-proteobacterium that inhabits a variety of ecosystems in tropical and subtropical regions, including the water and banks of the negro river in the brazilian amazon. this bacterium has been the subject of extensive study over the last three decades, due to its biotechnological properties, including the characteristic violacein pigment, which has antimicrobial and anti-tumoral activities. c. violaceum promotes the solubilization of gold in a mercur ...200415100997
identification of chromobacterium violaceum genes with potential biotechnological application in environmental detoxification.chromobacterium violaceum is a gram-negative bacterium found in a wide variety of tropical and subtropical ecosystems. the complete genome sequence of c. violaceum atcc 12472 is now available, and it has considerable biotechnological potential for various applications, such as environmental detoxification, as well as medical and agricultural use. we examined the biotechnological potential of c. violaceum for environmental detoxification. three operons, comprising the ars operon, involved in arse ...200415100998
molecular mechanism of violacein-mediated human leukemia cell death.violacein, a pigment isolated from chromobacterium violaceum in the amazon river, presents diverse biologic properties and attracts interest as a consequence of its antileukemic activity. elucidation of the molecular mechanism mediating this activity will provide further relevant information for understanding its effects on the cellular physiology of untransformed cells and for considering its possible clinical application. here, we show that violacein causes apoptosis in hl60 leukemic cells but ...200415130948
ym-254890 analogues, novel cyclic depsipeptides with galpha(q/11) inhibitory activity from chromobacterium sp. qs3666.the structure elucidation and biological activity of novel ym-254890 (1) analogues and semi-synthetic derivatives are described. three natural analogues, ym-254891 (2), ym-254892 (3), and ym-280193 (4), were isolated from the fermentation broth of chromobacterium sp. qs3666, and two hydrogenated derivatives, ym-385780 (5) and ym-385781 (6), were synthesized from ym-254890. their structures were determined by one- and two-dimensional nmr studies and mass spectrometry. among these compounds, two n ...200415158780
burkholderia cenocepacia phage bcepmu and a family of mu-like phages encoding potential pathogenesis factors.we have isolated bcepmu, a mu-like bacteriophage whose host range includes human pathogenic burkholderia cenocepacia (formally b. cepacia genomovar iii) isolates, and determined its complete 36748 bp genomic sequence. like enteric bacteriophage mu, the bcepmu genomic dna is flanked by variable host sequences, a result of transposon-mediated replication. the bcepmu genome encodes 53 proteins, including capsid assembly components related to those of mu, and tail sheath and tube proteins related to ...200415184022
use of sinorhizobium meliloti as an indicator for specific detection of long-chain n-acyl homoserine lactones.population-density-dependent gene expression in gram-negative bacteria involves the production of signal molecules characterized as n-acyl homoserine lactones (ahls). the synthesis of ahls by numerous microorganisms has been identified by using biosensor strains based on the agrobacterium tumefaciens and chromobacterium violaceum quorum-sensing systems. the symbiotic nitrogen-fixing bacterium sinorhizobium meliloti is rapidly becoming a model organism for the study of quorum sensing. this organi ...200415184178
effects of natural and chemically synthesized furanones on quorum sensing in chromobacterium violaceum.cell to cell signaling systems in gram-negative bacteria rely on small diffusible molecules such as the n-acylhomoserine lactones (ahl). these compounds are involved in the production of antibiotics, exoenzymes, virulence factors and biofilm formation. they belong to the class of furanone derivatives which are frequently found in nature as pheromones, flavor compounds or secondary metabolites. to obtain more information on the relation between molecular structure and quorum sensing, we tested a ...200415233843
two new bacterial pathogens of colorado potato beetle coleoptera: chrysomelidae).other than bacillus thuringiensis berliner, few bacteria are lethal to the colorado potato beetle (leptinotarsa decemlineata [say]), a major pest of potatoes and eggplant. expanded use of biologicals for the control of colorado potato beetle will improve resistance management, reduce pesticide use, and produce novel compounds for potential use in transgenic plants. using freeze-dried, rehydrated artificial diet in pellet form to screen bacteria lethal to other insects, we determined that strains ...200415279252
a simple screening protocol for the identification of quorum signal antagonists.quorum sensing (qs) is a mechanism by which diverse microorganisms can control specific processes in response to population density. a relatively well-known form of qs among proteobacteria involves production and subsequent response to acylated homoserine lactones (ahls). quorum sensing inhibition (qsi), targeting ahl-dependent signaling, has been reported as a strategy for the control of biofilm formation used by several marine organisms. we developed a simple soft agar overlay protocol, based ...200415279939
crystallization and preliminary x-ray analysis of a lipase from chromobacterium viscosum.lipase from chromobacterium viscosum has been purified to homogeneity and crystallized in a form suitable for x-ray diffraction analysis from 10-14% polyethylene glycol 4000 and 10-14% 2-methyl-2,4-pentane diol at ph 6.4 in the presence of 0.25%(w/v) n-octyl-beta-d-glucopyranoside. these crystals belong to space group p2(1)2(1)2 with refined lattice constants a = 41.1 a, b= 156.8, c = 43.6 a, indicating a cell content of one monomer per asymmetric unit of the crystal. the crystals diffract to a ...199415299463
flow microcalorimetric studies of phenol and its chlorinated derivatives and a theoretical evaluation of their possible inhibition mode on chromobacterium violaceum respiration.the general belief that chemical structure determines the biological effect of drugs has led to several techniques to establish structure-activity relationships (sar) that is useful in the development of more active compounds. predicting toxic effects based on sar, one can obtain toxicological data with a low cost-benefit ratio. chlorophenols that represent a class of toxic agents frequently used in industrial processes are not satisfactorily described in the literature in relation to their toxi ...200415336391
a novel galphaq/11-selective inhibitor.ym-254890, which was isolated from the culture broth of chromobacterium sp., inhibits adp-induced platelet aggregation and has antithrombotic and thrombolytic effects. ym-254890 blocks galpha(q/11)-coupled adp receptor p2y1-mediated ca(2+) mobilization. here we report that ym-254890 is a selective galpha(q/11) inhibitor. ym-254890 blocked ca(2+) mobilization mediated by several galpha(q/11)-coupled receptors but not by galpha(i)- or galpha(15)-coupled receptor, indicating that phospholipase cbet ...200415339913
[violacein: a molecule of biological interest originating from the soil-borne bacterium chromobacterium violaceum].soil micro-organisms have evolved functions that allow them to withstand the strong competition for survival that characterizes most of their habitats. the production of antibiotic or antifungal compounds is one of these mechanisms. the relevant molecules often exhibit valuable therapeutic properties.200415363621
vioc is a non-heme iron, alpha-ketoglutarate-dependent oxygenase that catalyzes the formation of 3s-hydroxy-l-arginine during viomycin biosynthesis. 200415368580
conversion of (2s)-arginine to (2s,3r)-capreomycidine by vioc and viod from the viomycin biosynthetic pathway of streptomyces sp. strain atcc11861. 200415368582
metal solubilization from metal-containing solid materials by cyanogenic chromobacterium violaceum.different cyanogenic bacterial strains (chromobacterium violaceum, pseudomonas fluorescens, bacillus megaterium) were cultivated under cyanide-forming conditions in the presence of metal-containing solids such as nickel powder or electronic scrap. all microorganisms were able to form water-soluble metal cyanides, however, with different efficiencies. c. violaceum was able to mobilize nickel as tetracyanonickelate [ni(cn)4(2-)] from fine-grained nickel powder. gold was microbially solubilized as ...200415380664
pathologic quiz case: a 13-year-old boy with a 2-day history of fever, vomiting, and mental status changes. chromobacterium violaceum bacteremia. 200415387687
cytotoxic effects of violacein in human uveal melanoma cell lines.violacein is the main pigment produced by chromobacterium violaceum, a saprophytic gram-negative bacillus. violacein is formed by the condensation of two modified tryptophan molecules and has potential anti-neoplastic effects. the purpose of this pilot study was to investigate the in vitro activity of violacein in human uveal melanoma cell lines. human uveal melanoma cell lines 92.1 and ocm-1 were incubated with five different concentrations of violacein (10(-5)-10(-9) m), and the total cellular ...200415457100
an analysis of type-iii secretion gene clusters in chromobacterium violaceum.chromobacterium violaceum is an environmental gram-negative bacterium that is common in soil and water in tropical and sub-tropical regions. it is also a model organism for studying quorum-sensing and is a rare but deadly human pathogen. recent completion of the genome sequence of c. violaceum strain atcc 12472 revealed the presence of genes associated with type-iii secretion systems (ttsss). one of these systems resembles the spi-1 system found in salmonella enterica, whereas another is similar ...200415488386
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