TitleAbstractYear(sorted ascending)
tigecycline-based versus sulbactam-based treatment for pneumonia involving multidrug-resistant acinetobacter calcoaceticus-acinetobacter baumannii complex.the treatment options for pneumonia involving multidrug-resistant acinetobacter calcoaceticus-acinetobacter baumannii (mdr acb) complex are limited, and the optimal treatment has not been established.201627496018
utility of whole-genome sequencing in characterizing acinetobacter epidemiology and analyzing hospital outbreaks.acinetobacter baumannii frequently causes nosocomial infections and outbreaks. whole-genome sequencing (wgs) is a promising technique for strain typing and outbreak investigations. we compared the performance of conventional methods with wgs for strain typing clinical acinetobacter isolates and analyzing a carbapenem-resistant a. baumannii (crab) outbreak. we performed two band-based typing techniques (pulsed-field gel electrophoresis and repetitive extragenic palindromic-pcr), multilocus sequen ...201626699703
acinetobacter seifertii isolated from china: genomic sequence and molecular epidemiology analyses.clinical infections caused by acinetobacter spp. have increasing public health concerns because of their global occurrence and ability to acquire multidrug resistance. acinetobacter calcoaceticus-acinetobacter baumannii (acb) complex encompasses a. calcoaceticus, a. baumannii, a. pittii (formerly genomic species 3), and a nosocomial (formerly genomic species 13tu), which are predominantly responsible for clinical pathogenesis in the acinetobacter genus. in our previous study, a putative novel sp ...201626945401
multi-drug-resistant acinetobacter calcoaceticus-acinetobacter baumannii complex infection outbreak in dogs and cats in a veterinary hospital.members of the acinetobacter calcoaceticus-acinetobacter baumannii complex cause severe outbreaks in humans, and are increasingly reported in animals.201627709647
pcr assay based on the gyrb gene for rapid identification of acinetobacter baumannii-calcoaceticus complex at specie level.the genus acinetobacter sp. comprises more than 50 species, and four are closely related and difficult to be distinguished by either phenotypic or genotypic methods: the acinetobacter calcoaceticus-baumannii complex (abc). the correct identification at species level is necessary mainly due to the epidemiological aspects.201627605498
enrichment of acinetobacter spp. from food samples.relatively little is known about the role of foods in the chain of transmission of acinetobacters and the occurrence of different acinetobacter spp. in foods. currently, there is no standard procedure to recover acinetobacters from food in order to gain insight into the food-related ecology and epidemiology of acinetobacters. this study aimed to assess whether enrichment in dijkshoorn enrichment medium followed by plating in chromagar™ acinetobacter medium is a useful method for the isolation of ...201626742623
novel oxadiazole thioglycosides as potential anti-acinetobacter agents.the glycosylation of 1,3,4-oxadiazole-2-thiones has been performed with peracetylated β-pyranosyl bromide in the presence of potassium carbonate. deprotection of acetylated thioglycosides was necessary for increasing their antibacterial effects. the structures of nucleosides were confirmed by (1)h nmr, (13)c nmr and hrms. the anomeric protons of nucleosides c1-4 were assigned to the doublet, confirming the β-configuration. the synthesized compounds were tested for their antimicrobial activity ag ...201628243273
rapid species identification and epidemiological analysis of carbapenem-resistant acinetobacter spp. by a pcr-based open reading frame typing method.the spread of carbapenem-resistant acinetobacter spp. has become a global problem. in this study, 18 carbapenem-resistant acinetobacter calcoaceticus-baumannii (acb) complexes, identified using a conventional biochemical method at our hospital during 2004-2013, were studied for species identification and epidemiological analyses. species identification was performed using matrix-assisted laser desorption ionization-time-of-flight ms, a partial sequence analysis of rpob and a pcr-based orf typing ...201627412356
structural basis of selective aromatic pollutant sensing by the effector binding domain of mopr, an ntrc family transcriptional regulator.phenol and its derivatives are common pollutants that are present in industrial discharge and are major xenobiotics that lead to water pollution. to monitor as well as improve water quality, attempts have been made in the past to engineer bacterial in vivo biosensors. however, due to the paucity of structural information, there is insufficiency in gauging the factors that lead to high sensitivity and selectivity, thereby impeding development. here, we present the crystal structure of the sensor ...201627362503
the effects of sodium hypochlorite against selected drinking water-isolated bacteria in planktonic and sessile states. 201627156214
isolation and characterization of fipronil degrading acinetobacter calcoaceticus and acinetobacter oleivorans from rhizospheric zone of zea enrichment culture technique was used for the isolation of bacteria capable of utilizing fipronil as a sole source of carbon and energy. based on morphological, biochemical characteristics and phylogenetic analysis of 16s rrna sequence, the bacterial strains were identified as acinetobacter calcoaceticus and acinetobacter oleivorans. biodegradation experiments were conducted in loamy sand soil samples fortified with fipronil (50 µg kg(-1)) and inoculated with acinetobacter sp. cells (45 × 10( ...201627084098
antibiotic resistance profiles and genetic similarities within a new generation of carbapenem-resistant acinetobacter calcoaceticus-a. baumannii complex resistotypes in bosnia and herzegovina.acinetobacter calcoaceticus-a. baumannii complex (acb complex) is a nosocomial pathogen. due to its high ability to develop antibiotic resistance, it has become a problematic challenge in the modern healthcare system. the molecular and genetic mechanisms of gaining multidrug resistance in acb complex are well known. this study focuses on providing an overview of the antibiotic resistance profiles, genetic similarities and resistotypes, and general characteristics of carbapenem-resistant acb comp ...201627082787
intensive care unit-acquired infections in a tertiary care hospital: an epidemiologic survey and influence on patient outcomes.nosocomial infections are common in intensive care units (icus), but the pattern of infections and the distribution of microorganisms vary. we studied the icu-acquired infections and their effect on patient outcomes in our icu.201626944004
first report of oxa-72-producing acinetobacter calcoaceticus in lebanon.emergence of carbapenem-resistant acinetobacter spp. has been increasingly reported worldwide. we report here the first detection of an acinetobacter calcoaceticus isolate from vegetables in lebanon carrying the bla oxa-72 gene. these findings show that the lebanese environment may constitute a potential reservoir for this antibiotic resistance gene.201626858838
incidence, management, and visual outcomes in pediatric endophthalmitis following cataract surgery by a single report the incidence of endophthalmitis following cataract surgery by a single surgeon in children and to describe its microbiological profile, management, and visual outcomes.201627343836
evaluation of an ultraviolet c light-emitting device for disinfection of electronic devices.a tabletop-type ultraviolet c (uvc) light-emitting disinfecting device was evaluated for microbiologic effectiveness, safety, usability, and end-user satisfaction.201627742144
characteristics of invasive acinetobacter species isolates recovered in a pediatric academic center.acinetobacter species are associated with increasing mortality due to emerging drug-resistance. pediatric acinetobacter infections are largely undefined in developed countries and clinical laboratory identification methods do not reliably differentiate between members of the acinetobacter calcoaceticus-baumannii complex, leading to improper identification. therefore we aimed to determine risk factors for invasive acinetobacter infections within an academic, pediatric setting as well as defining ...201627449800
[synthesis of surfactants by rhodococcus erythropolis imv ac-5017, acinetobacter calcoaceticus imv b-7241 and nocardia vaccinii imv b-7405 on industrial waste].the synthesis of surfactants by rhodococcus erythropolis imv ac-5017, acinetobacter calcoaceticus imv b-7241 and nocardia vaccinii imv b-7405 on industrial waste (food and oil-processing industry, production of biodiesel) was investigated. the possibility of replacing the expensive substrates (n-hexadecane and ethanol) by industrial waste (oil and fat industry, fried sunflower oil, glycerol, liquid paraffin) for the surfactant biosynthesis was established. the conditional concentration of surfac ...201625000725
[effect of cu2+ on synthesis of biosurfactants of acinetobacter calcoaceticus imv b-7241 and rhodococcus erythropolis imv ac-5017].synthesis of biosurfactants (surface-active substances, sas) was investigated under the conditions of growth of rhodococcus erythropolis imv ac-5017 and acinetobacter calcoaceticus imv b-7241 on hydrophobic (n-hexadecane, liquid paraffins, sunflower oil) and hydrophilic (ethanol) substrates depending on concentration (0.01-0.5 mm) and time of copper cations introduction in the medium. it is established that cu2+ addition in the exponential phase of growth of the strains imv b-7241 and imv ac-501 ...201623516834
development and evaluation of a core genome multilocus typing scheme for whole-genome sequence-based typing of acinetobacter baumannii.we have employed whole genome sequencing to define and evaluate a core genome multilocus sequence typing (cgmlst) scheme for acinetobacter baumannii. to define a core genome we downloaded a total of 1,573 putative a. baumannii genomes from ncbi as well as representative isolates belonging to the eight previously described international a. baumannii clonal lineages. the core genome was then employed against a total of fifty-three carbapenem-resistant a. baumannii isolates that were previously typ ...201728594944
complete genome sequence and methylome analysis of acinetobacter calcoaceticus 65.acinetobacter calcoaceticus 65 is the original source strain for the restriction enzyme acc65i. its complete sequence and full methylome were determined using single-molecule real-time (smrt) sequencing.201728336599
effects of meropenem exposure in persister cells of acinetobacter evaluate the influence of meropenem in the acinetobacter calcoaceticus-baumannii (acb) persister levels.201728111984
clinical and microbiological characteristics of bloodstream infections among patients with haematological malignancies with and without neutropenia at a medical centre in northern taiwan, 2008-2013.this study aimed to investigate the epidemiology and microbiology of bloodstream infections (bsis) in patients with haematological malignancies. clinical characteristics and microbiology of 2083 patients with haematological malignancy who were treated for bsi from 2008 to 2013 at a medical centre in taiwan were retrospectively reviewed. lymphoma (38.1%) was the most common, followed by acute myeloid leukaemia (30.9%). of the 2090 non-duplicate bsi isolates, 1310 (62.7%) were recovered from patie ...201728109554
engineering cyclohexanone monooxygenase for the production of methyl propanoate.a previous study showed that cyclohexanone monooxygenase from acinetobacter calcoaceticus (acchmo) catalyzes the baeyer-villiger oxidation of 2-butanone, yielding ethyl acetate and methyl propanoate as products. methyl propanoate is of industrial interest as a precursor of acrylic plastic. here, various residues near the substrate and nadp(+) binding sites in acchmo were subjected to saturation mutagenesis to enhance both the activity on 2-butanone and the regioselectivity toward methyl propanoa ...201727935281
isolation and identification of acinetobacter species with special reference to antibiotic resistance.acinetobacter is clinically important pathogen with widespread resistance to various antibiotics. we assessed the incidence of acinetobacter infection at a tertiary care hospital, analyze their resistance pattern and identify the production of extended spectrum β-lactamases (esbls) and metallo β-lactamases (mbls).201725810655
epidemiology and trends in the antibiotic susceptibilities of gram-negative bacilli isolated from patients with intra-abdominal infections in the asia-pacific region, 2010-2013.this study was conducted to investigate the epidemiology and antimicrobial susceptibility patterns of gram-negative bacilli (gnb) isolated from intra-abdominal infections (iais) in the asia-pacific region (apr) from 2010-2013. a total of 17 350 isolates were collected from 54 centres in 13 countries in the apr. the three most commonly isolated gnb were escherichia coli (46.1%), klebsiella pneumoniae (19.3%) and pseudomonas aeruginosa (9.8%). overall, the rates of extended-spectrum β-lactamase (e ...201728435019
an in vitro synthetic biosystem based on acetate for production of phloroglucinol.phloroglucinol is an important chemical, and the biosynthesis processes which can convert glucose to phloroglucinol have been established. however, due to approximate 80% of the glucose being transformed into undesirable by-products and biomass, this biosynthesis process only shows a low yield with the highest value of about 0.20 g/g. the industrial applications are usually hindered by the low current productivity and yield and also by the high costs. generally, several different aspects limit t ...201728789688
carbapenem-resistant acinetobacter baumannii contamination in an intensive care unit.acinetobacter baumannii is a major pathogen causing infections in intensive care units (icus). in this study, we aimed to evaluate the presence of a. baumannii in an icu environment and gloves from icu workers and to characterize the antimicrobial resistance of the isolates in comparison with those isolated from icu patients at the same hospital.201728562751
erratum for ho et al., "complete genome sequence of acinetobacter calcoaceticus ca16, a bacterium capable of degrading diesel and lignin". 201728774994
structure guided design of protein biosensors for phenolic pollutants.phenolic aromatic compounds are a major source of environmental pollution. currently there are no in situ methods for specifically and selectively detecting these pollutants. here, we exploit the nature's biosensory machinery by employing acinetobacter calcoaceticus ncib8250 protein, mopr, as a model system to develop biosensors for selective detection of a spectrum of these pollutants. the x-ray structure of the sensor domain of mopr was used as a scaffold for logic-based tunable biosensor desi ...201728723202
first report of cavitary pneumonia due to community-acquired acinetobacter pittii, study of virulence and overview of pathogenesis and treatment.acinetobacter pittii is a nosocomial pathogen rarely involved in community-acquired infections. we report for the first time that a. pittii can be responsible for cavitary community-acquired pneumonia and study its virulence, and discuss its pathogenesis and treatment options.201728683724
complete genome sequence of acinetobacter calcoaceticus ca16, a bacterium capable of degrading diesel and lignin.we report here the complete assembled genome sequence of acinetobacter calcoaceticus ca16, which is capable of utilizing diesel and lignin as a sole carbon source. ca16 contains a 4,110,074-bp chromosome and a 5,920-bp plasmid. the assembled sequences will help elucidate potential metabolic pathways and mechanisms responsible for ca16's hydrocarbon degradation ability.201728619790
characterization and degradation potential of diesel-degrading bacterial strains for application in bioremediation.bioremediation of polluted soils is a promising technique with low environmental impact, which uses soil organisms to degrade soil contaminants. in this study, 19 bacterial strains isolated from a diesel-contaminated soil were screened for diesel-degrading potential, biosurfactant production, and biofilm formation abilities, all desirable characteristics when selecting strains for re-inoculation into hydrocarbon-contaminated soils. diesel degradation rates were determined in vitro in minimal med ...201728598213
the role of the genetic elements bla oxa and is aba 1 in the acinetobacter calcoaceticus-acinetobacter baumannii complex in carbapenem resistance in the hospital setting.members of the acinetobacter genus are key pathogens that cause healthcare-associated infections, and they tend to spread and develop new antibiotic resistance mechanisms. oxacillinases are primarily responsible for resistance to carbapenem antibiotics. higher rates of carbapenem hydrolysis might be ascribed to insertion sequences, such as the isaba1 sequence, near bla oxa genes. the present study examined the occurrence of the genetic elements bla oxa and isaba1 and their relationship with susc ...201727598629
emergence of new delhi metallo-beta-lactamase 1 and other carbapenemase-producing acinetobacter calcoaceticus-baumannii complex among patients in hospitals in ha noi, viet nam.acinetobacter baumannii is an important cause of multidrug-resistant hospital acquired infections in the world. here, we investigate the presence of ndm-1 and other carbapenemases among carbapenem-resistant a. baumannii isolated between august 2010 and december 2014 from three large hospitals in hanoi, vietnam. we identified 23/582 isolates (4 %) (11 from hospital a, five from hospital b, and seven from hospital c) that were ndm-1 positive, and among them 18 carried additional carbapenemase gene ...201727714593
lettuce and fruits as a source of multidrug resistant acinetobacter spp.the role of ready-to-eat products as a reservoir of pathogenic species of acinetobacter remains unclear. the objective of the present study was to evaluate the presence of acinetobacter species in lettuces and fruits marketed in portugal, and their susceptibility to antimicrobials. acinetobacter spp. were isolated from 77.9% of the samples and these microorganisms were also found as endophytes (i.e. present within the plant tissue) in 12 of 20 samples of lettuces analysed. among 253 isolates tha ...201728213015
draft genome sequence of jvap01t, the type strain of the novel species acinetobacter, we report the draft genome sequence of the type strain of acinetobacter dijkshoorniae, a novel human pathogen within the acinetobacter calcoaceticus-acinetobacter baumannii (acb) complex. strain jvap01(t) has an estimated genome size of 3.9 mb, exhibits a 38.8% g+c content, and carries a plasmid with the blandm-1 carbapenemase gene.201728082506
clinical and pathophysiological overview of acinetobacter infections: a century of challenges.summaryacinetobacter is a complex genus, and historically, there has been confusion about the existence of multiple species. the species commonly cause nosocomial infections, predominantly aspiration pneumonia and catheter-associated bacteremia, but can also cause soft tissue and urinary tract infections. community-acquired infections by acinetobacter spp. are increasingly reported. transmission of acinetobacter and subsequent disease is facilitated by the organism's environmental tenacity, resi ...201727974412
comparison between bacteremia caused by acinetobacter pittii and acinetobacter nosocomialis.patients with acinetobacter pittii and acinetobacter nosocomialis bacteremia have lower mortality rates than those with acinetobacter baumannii bacteremia. however, it is unknown whether these organisms differ in outcomes of bacteremic patients. we conducted this study to answer this question.201725735795
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