Publications

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[spirochaetosis in ducks]. 19695366693
in vitro susceptibility of oral spirochetes to metronidazole. 19704922198
nonspecific lung abscess. a perspective. 19725059446
localization of bacteria in the gastrointestinal tract: a possible explanation of intestinal spirochaetosis.the large intestine of rats and dogs was examined by light and electron microscopy. in both species localization of bacteria in specific areas of the tissue was observed. fusiform bacteria mixed with spirochaetes were seen at the opening of the crypts into the large bowel. however, at the base of the crypts homogeneous populations of spiral organisms were found; some crypts contained borrelia-type spirochaetes, whereas others contained spiral bacteria with other morphology. very few spiral bacte ...19734716551
a directly cross-linked l-ornithine-containing peptidoglycan in cell walls of spirochaeta stenostrepta. 19734747604
distinctive renal lesion of spirochete-infected brine shrimp.in spirochete-infected artemia, the renal tubule exhibited a lesion consisting of a group of spirochetes situated in an indentation of the base of the epithelium and involving discontinuity of the basal lamina.19744851408
method of testing antibiotic sensitivity of spirochaetes, using antibiotic discs. 19725083440
[on inactivity of the factor of resistance of spirochetes to penicillin in syphilitic patients with persistent positive serological tests, in presence of cephaloridine in vitro]. 19655178887
fatty acid composition of spirochaeta stenostrepta.the fatty acid composition of spirochaeta stenostrepta consists primarily of saturated, branch-chained fatty acids. iso-c(15), anteiso-c(15), iso-c(17), and anteiso-c(17) represent 66% of the total fatty acids.19725079081
plaque development and gingivitis in the primary dentition. 19734509109
spirochaetal invasion of the colonic epithelium in swine dysentery. 19715572539
[morphological studies on the axial fibrils of certain oral spirochetes]. 19734513247
[pathogenicity of oral spirochaeta]. 19734519756
[fine structure of oral spirochetes, especially on the intracytoplasmic structure (author's transl)]. 19744523124
[electron microscopic studies on fine structure of oral spirochetes]. 19685251798
spirochaetal invasion of the colonic mucosa in a syndrome resembling swine dysentery following experimental trichuris suis infection in weaned pigs. 19724539730
axial fibrils of anaerobic spirochetes: ultrastructure and chemical characteristics. 19724552535
a virus associated with sr-spirochetes of drosophila nebulosa.a virus is associated with a strain of transovarially-transmitted sr-spirochetes, nsr, of drosophila. this virus, designated spv-1, is able to infect and to multiply in another strain of sr-spirochetes, wsr, thereby eliminating the sr condition from the host flies. spv-1 contains dna, has a buoyant density of 1.480 in cscl, and is spherical in shape, measuring 50-60 nm in diameter.19705274480
[reiter's spirochete agglutination test, römer and schilpköter modification, in syphilis serodiagnosis (clinico-serological contribution)]. 19675633133
the classification of free-living spirochetes. 19685709371
evidence for the presence of circulating antibodies to an oral spirochete in the sera of clinic patients. 19705266135
[achievements in control of tick-borne spirochaetosis in the ussr for 50 years]. 19685734358
[possibilities of transmission of tick relapsing fever by lice. v. the dynamics of bor. sogdianae multiplication in hemolymph of body lice]. 19685734369
[serological studies on oral spirochetes]. 19705270752
[on the usefulness of a new agglutination test (s.p.a.) in the diagnosis of syphilis]. 19685745042
effect of erythromycin on dental plaque and plaque forming microorganisms of man. 19695255346
spirochaeta aurantia, a pigmented, facultatively anaerobic spirochete.a strain of spirochaeta aurantia was isolated from mud by a procedure involving migration of the organisms through cellulose ester filter discs (0.3-mum pore diameter) onto the surface of culture plates. the helical cells measured 0.3 by 10 to 20 mum during exponential growth. electron microscopy showed the presence of two subterminally inserted axial fibrils partially overlapping in a 1-2-1 arrangement. an outer envelope, exhibiting a polygonal substructure, was observed. the spirochete grew ei ...19695764339
intestinal spirochetes and disease in dogs. lf-27. 19655295040
[structure of spirochetes. ii. study of the genus cristispira by optic microscope and electron microscope]. 19655848618
[secondary syphilis. report of 2 cases]. 19705449337
[cerebral syphilitic gumma. 3 cases reports]. 19705453715
[oral spirochetes antibodies observed in the human serum]. 19715282860
[some characters on 2 strains (e-30,e-31) of oral spirochetes]. 19715287278
[experimental infection of oral spirochetes into rabbits and guinea pigs]. 19715282866
studies on the preparation of a spirochaete vaccine. i. 19665931151
carbohydrate metabolism in spirochaeta stenostrepta.the pathways of carbohydrate metabolism in spirochaeta stenostrepta, a free-living, strictly anaerobic spirochete, were studied. the organism fermented glucose to ethyl alcohol, acetate, lactate, co(2), and h(2). assays of enzymatic activities in cell extracts, and determinations of radioactivity distribution in products formed from (14)c-labeled glucose indicated that s. stenostrepta degraded glucose via the embden-meyerhof pathway. the spirochete utilized a clostridial-type clastic reaction to ...19705423371
influence of type and level of grain and diethylstilbestrol on the rumen microbial populations of steers fed all-concentrate diets. 19705481275
paper electrophoretic studies of the serum proteins of chicks during experimental spirochetosis. 19665963858
an agent possibly associated with swine dysentery. 19705529160
[isolation and pure cultivation of oral spirochetes, and electron microscopic studies on the cell structure as well as the biological characteris of pure cultivation strains]. 19685251797
intestinal spirochaetosis.an abnormal condition of the large intestine is described in which the surface epithelium is infested by short spirochaetes. diagnosis can be made by light microscopy. a review of 14 cases diagnosed by rectal biopsy and 62 cases involving the appendix shows no consistent symptom complex. the possible significance is discussed.19715548558
the role of the bursa of fabricius in immunity against spirochetosis in fowls. 19675597724
[level of study and results of the use of an anti-fuso-spirochetic preparation in some periodontopathies]. 19685248454
luetic lymphadenitis: a clinical and histologic study of 20 cases. 19705416766
nucleic acids from saprospira grandis: the absence of 2'-o-methyl rna. 19705413480
otitis media in the trinidad tree porcupine (coendou prehensilis). 19705465297
studies on the preparation of spirochaete vaccine. ii. research on its economic aspects. 19676045074
[on the possibility of transmission of tick relapsing fever by lice. 3. further data on the fate of tick relapsing fever spirochaetae in the organism of body lice]. 19675609982
antibodies to lyme-disease spirochaete in european lymphocytic meningoradiculitis (bannwarth's syndrome) 19836136679
[fibrinous bronchitis (plastic pseudomembranous bronchitis). spirochetal bronchitis (de castellani)]. 19675616124
electronmicroscopic and taxonomic characterization of a spirochete parasitizing the praeputial diverticulum of swine. 19675628073
[on results of control of a tick vector of spirochaetosis in village foci of central asian republics]. 19685715116
fine structure of spirochaeta stenostrepta, a free-living, anaerobic spirochete.the fine structure of spirochaeta stenostrepta strain z1, a free-living anaerobic spirochete, was studied by electron microscopy. the organism possessed a coiled protoplasmic cylinder, an axial filament inserted subterminally, and a loosely fitting sheath which enclosed both the protoplasmic cylinder and the axial filament. the axial filament consisted of two fibrils partially overlapping in a 1-2-1 arrangement. the axial fibrils appeared to possess a sheath surrounding an inner core. both inner ...19685732511
[ixodes ricinus spirochaeta: probable pathogen responsible for herxheimer's acrodermatitis chronica atrophicans]. 19846363030
[serum antibodies against ixodes ricinus spirochaeta in acrodermatitis chronica atrophicans (herxheimer)].using indirect immunofluorescence, igg antibodies against the recently detected ixodes-ricinus-spirochaeta, which causes erythema chronicum migrans could be demonstrated in all 21 persons with acrodermatitis chronica atrophicans. titers were from 1 : 64 to 1 : 1024, specific igm antibodies were demonstrable in only 5 patients in a titer of 1 : 64. even after treatment with penicillin high igg antibody titers of up to 1 : 1024 were found. fourfold decreases could be found only once for each igg a ...19846363031
[on the classification of the causative agent of "ukrainian" tick relapsing eer]. 19685732638
[fever and penicillin therapy of progressive paralysis from the neuropathological viewpoint]. 19695791903
[experimental infection of sterile ornithodous ticks with spirochaetae by feeding them on infected chick embryos]. 19655869238
lyme disease: a review. 19846394029
[immunologic identification of various strains of spirochaetes in chickens]. 19685736426
[a method of counting spirochaeta anserina in the blood]. 19685754514
thirteen british cases of erythema chronicum migrans, a spirochaetal disease.thirteen british cases of erythema chronicum migrans are reported. an antibody to the lyme disease spirochaete was found in three of five recent cases, but lyme disease was not seen. the distribution and life cycle of the tick ixodes ricinus is described and related to the occurrence of erythema chronicum migrans in great britain.19846477830
[tick-borne spirochaetales infection of lyme (lyme disease)]. 19846533687
quantitative differences in spirochetal antibody observed in periodontal disease. 19685244722
[the spirochetal etiology of erythema chronicum migrans and of meningo-polyneuritis garin-bujadoux-bannwarth].erythema chronicum migrans and tick-borne meningo-polyneuritis garin-bujadoux-bannwarth are caused by a spirochete transmitted by ixodes ricinus. the same is true for lyme disease, which is the erythema chronicum migrans infection of north-america transmitted by ticks of the same genus. in europe, this etiology is indicated by demonstration of igg and igm antibodies against borrelia duttoni during the course of infection and by immunofluorescence staining of spirochetes in ticks at sites of infe ...19836659638
incidence and distribution of spirochetes in the digestive tract of dogs. 19655882556
[on the mechanism of the antispirochaetal action of benzylpenicillin]. 19675608947
cytological and biochemical studies on the blood of normal and spirochaete-infected ducks. 19665950229
atypical transovarial transmission of sex ratio spirochetes by drosophila robusta sturtevant. 19665959742
the expression of maternally-transmitted sex ratio condition (sr) in two strains of drosophila melanogaster. 19665965031
[effects of organic polycations on the outflow and retention of protoplasmic substances from erythrocytes and microorganisms]. 19645878231
uptake of d-xylose and d-glucose by spirochaeta aurantia.uptake of d-[14c]glucose and d-[14c]xylose by spirochaeta aurantia was demonstrated to be osmotic shock sensitive and to require a high-energy phosphorylated compound rather than a proton motive force. these features are similar to those of binding protein-mediated transport systems in other gram-negative bacteria.19846735985
the bacteriology of the fuso-spirochetal complex. 19685244523
studies on the histopathology of avian spirochaetosis. 19665977584
[spirochetes. i. metabolism and physiology]. 19807024582
[electron microscopic demonstration of succinodehydrogenase in reiter's spirochaeta]. 19665987516
[the importance of bacterial flora in parodontopathies of diabetics]. 19675604758
[experimental transmission by the ticks ornithodorus alactaglis and o. verrucosus of the causative agent of recurrent typhus: spirochaeta sogdianum]. 19675605568
inhibition of spirochaeta aurantia chemotaxis by neurotoxins.the effects of neurotoxic compounds on the chemotactic response of spirochaeta aurantia were investigated. in the presence of neurotoxins that affect action potential generation and transmission in excitable eucaryotic cells, d-xylose taxis was inhibited by 69 to 93%. inhibition of chemotaxis was not due to decreased viability or motility. this study supports the hypothesis that the molecular basis for sensory signal transduction in s. aurantia involves ion fluxes across the cytoplasmic membrane ...19836136501
meptazinol diminishes the jarisch-herxheimer reaction of relapsing fever.naloxone, an opioid antagonist, and meptazinol, an opioid antagonist with agonist properties, were tested in a double-blind placebo-controlled trial in 24 ethiopian patients with louse-borne relapsing fever. the potentially fatal jarisch-herxheimer reaction (j-hr), which invariably follows tetracycline treatment of the disease, was unaffected by naloxone, 30-40 mg intravenously, but was diminished by meptazinol, 300-500 mg intravenously. compared with naloxone and placebo, meptazinol reduced the ...19836132178
sterol requirement for the growth of treponema hyodysenteriae.the addition of cholesterol to a liquid medium containing bovine serum albumin (bsa) fraction v or acetone-delipidized bsa fraction v instead of serum stimulated the growth of treponema hyodysenteriae, a serum-requiring spirochaete associated with swine dysentery. as little as 1.25 micrograms cholesterol ml-1 increased viable counts about 1000-fold. sitosterol and cholestanol, but not pregnenalone, cholestenone or stigmasteriol, produced a growth response comparable to that of cholesterol. the r ...19807373284
enzymatic activities for interconversion of purines in spirochetes.enzymatic activities that catalyze the interconversion of purines and purine derivatives were detected in cell extracts of spirochaeta aurantia, spirochaeta stenostrepta, treponema succinifaciens, and treponema denticola. phosphoribosyltransferase activities present in cell extracts of each of the four spirochete species functioned in the conversion of adenine, hypoxanthine, and guanine to amp, imp, and gmp, respectively. nucleotidase activities in the extracts mediated the formation of nucleosi ...19826292162
ticks and the human skin. 19676071836
[analysis of the oral bacterial flora in subjects with periodontal diseases].a bacterioscopic study of the bacterial flora of 15 healthy and 15 periodontal disease carriers is presented in relation to the possibly pathogenetic role of oral bacterial flora in the development of human periodontal disease. study samples taken from sulcus and gingival pockets were examined by darkfield microscopy. results show that bacterial flora from periodontal disease subjects differs from that in healthy subjects in that spirochetes are present and the incidence of straight and motile r ...19836349662
[agglutination of reiter's spirochete in serodiagnosis of syphilis]. 19676073270
[treponema pallidum or spirochaeta pallida?].first schaudinn and hoffmann named the causative organism of syphilis spirochaeta pallida. short time later schaudinn proposed the name treponema. he mentioned it in a letter of october 14, 1905 to hoffmann. he supposed that this germ may be a flagellate. this was not correct. the electron-microscopic investigations revealed that this idea did not concur. therefore it is better to call them spirochaeta pallida and not treponema pallidum any more.19836363355
immunization of rabbits with spirochaeta aurantia does not induce resistance to treponema pallidum.rabbits were immunized with viable spirochaeta aurantia, a free-living, facultative anaerobic spirochete that is similar in some biochemical characteristics to treponema pallidum, a parasitic, microaerophilic spirochete. single and multiple immunizations with living s. aurantia, with or without freund's incomplete adjuvant, freund's complete adjuvant, or heat-killed t. pallidum, were carried out over a four-month period. living s. aurantia was neither toxic nor virulent for rabbits. immunized ra ...19846369574
ecology of spirochetes. 19846388490
chemoattractants elicit methylation of specific polypeptides in spirochaeta aurantia.on the basis of this investigation, chemotaxis in spirochaeta aurantia correlates with methylation of specific polypeptides which are presumed to be analogous to the methyl-accepting chemotaxis proteins (mcps) in bacteria such as escherichia coli. the polypeptides exhibited apparent molecular weights in the range of 55,000 to 65,000. generally, two major presumptive mcp bands and three minor bands were observed on sodium dodecyl sulfate-polyacrylamide gels. upon addition of d-glucose to s. auran ...19836413498
selection of ion channel elements in the serine and aspartate methyl-accepting chemotaxis proteins of bacteria.two plausible, transmembrane ion channel elements (these 'elements' are alpha-helical sequences of 24 amino acids in which polar, hydrophilic side chains occupy one side and hydrophobic side chains the other) have been identified in the serine chemoreceptor-methyl-accepting chemotaxis protein (mcp) (serr) of e. coli and the aspartate chemoreceptor-mcp (aspr) of s. typhimurium. that the chemoreceptor might serve as, or activate, an ion channel is supported strongly by the occurrence of membrane d ...19836312987
chemical compositions of cell walls and polysaccharide fractions of spirochetes.cellular polysaccharide fractions of various representative members of genera of the family spirochaetaceae were obtained by the ammonium hydroxide extraction method. the sugar composition of the polysaccharide preparations was complex and many kinds of sugars such as rhamnose, fucose, ribose, xylose, mannose, galactose, and glucose were detected in all of the spirochetes tested. of particular interest was the presence of 4-o-methylmannose as a constituent polysaccharide in members of the genus ...19846472134
antiquity of the lyme-disease spirochaete in europe. 19957475797
ability of transovarially and subsequent transstadially infected ixodes hexagonus ticks to maintain and transmit borrelia burgdorferi in the laboratory.in a previous study, transstadial and transovarial survival of borrelia burgdorferi in ixodes hexagonus and transmission to laboratory mice via the bite of infected females were demonstrated. here, we report the ability of i. hexagonus progeny infected transovarially to maintain and transmit the spirochaete to the host. ticks were examined for spirochaetes by direct immunofluorescence antibody test. i. hexagonus larvae derived from the parental transstadially infected females were fed on two whi ...19937628234
acquisition of borrelia burgdorferi by ixodes ricinus ticks fed on the european hedgehog, erinaceus europaeus l.a hedgehog, erinaceus europaeus, was found to be heavily infested with larval and nymphal ixodes ricinus in a forest park in co. galway, ireland. a large proportion of the ticks that engorged and detached were infected with the spirochaete, borrelia burgdorferi, the causative agent of human lyme borreliosis. the identity of these spirochaetes was confirmed by immunofluorescent assay with b. burgdorferi-specific monoclonal antibody and by polymerase chain reaction test and they were transmitted f ...19947628256
intestinal spirochaetes. 19846143949
lyme disease: a review.lyme disease is an uncommon multisystem spirochaetal infection that has attracted public and media attention in the united kingdom during the last few years. the spirochaete, borrelia burgdorferi, is transmitted through the bite of an infected tick. ticks are found throughout the uk in rural habitats and areas of urban parkland which attract many visitors. the illness can present with skin, nervous system, joint or other manifestations although infection may be asymptomatic. the risk of infectio ...19937693167
[diagnosis of lyme borreliosis].lyme borreliosis is an infectious disease, caused by the spirochaete borrelia burgdorferi and transmitted by ticks, in our regions by the tick ixodes ricinus. the disease mainly affects skin, nervous system, joints and heart. lyme borreliosis develops in three stages, and the various clinical manifestations may assigned to the respective stages. as far as skin is concerned, in stage i typically appears erythema chronicum migrans, very often accompanied by flu-like symptoms; in stage iii, months ...19957610528
expression of truncated and full-length forms of the lyme disease borrelia outer surface protein a in escherichia coli.the lipidated major outer surface protein, ospa, of the lyme disease spirochaete may be important in the pathogenesis during lyme borreliosis. to produce sufficient amounts of purified ospa variants to perform pathogenesis studies in vivo and in vitro, different recombinant ospa expression systems in escherichia coli were constructed. recombinant ospa variants were produced as a full-length molecule, as a truncated variant lacking the n-terminal lipidated cysteine, or as a fusion protein with th ...19957756835
prevalence of ticks in relation to their role as vector of borrelia burgdorferi under autochthone conditions.a total of 59 (78.7%) of 75 areas were found to be inhabitated by ticks; all the 4335 collected ticks were identified as ixodes ricinus. both nymphs and adults were found to be more active during the late spring and early summer months. ticks of 29 recreation areas were found to be carrying spirochaetes. considering the total number of 75 recreation areas examined and the total number of 59 areas inhabitated by ticks the percentage was 38.7 and 49.2 respectively. the positivity rate by dark fiel ...19957550446
studies on fowl spirochaetosis. 1. preparation of a vaccine. 19655893201
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