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antibodies to borrelia burgdorferi in dogs in north carolina.an indirect immunofluorescence assay was used to detect antibodies against borrelia burgdorferi in sera from 600 dogs in 1983 and 402 dogs in 1985. in 1983, the overall prevalence rate of dogs with b burgdorferi titers greater than or equal to 1:64 was 3.6%, whereas in 1985, the prevalence rate was 2.7%. an unexplainable higher seroprevalence was detected in 1 group of dogs tested in 1983. these dogs were from the southern coastal plains of north carolina. in the dogs tested in 1985, this region ...19883288020
[the spectrum of lyme borreliosis from the dermatologic viewpoint].erythema chronicum migrans, lymphadenosis benigna cutis and acrodermatitis chronica atrophicans represent the dermatological manifestations of the multi-organ disease lyme borreliosis. koch's requirements of evidence for an infectious disease, demonstration of the bacterium, transfer, and culture have proven borrelia burgdorferi to be the causative agent of the above mentioned skin diseases. this justifies a penicillin therapy, that has been administered in europe empirically for the last 30 yea ...19883289873
the urinary bladder, a consistent source of borrelia burgdorferi in experimentally infected white-footed mice (peromyscus leucopus).white-footed mice, peromyscus leucopus, were experimentally infected in the laboratory with borrelia burgdorferi, the causative agent of lyme disease. after mice were infected by intraperitoneal or subcutaneous inoculation or by tick bite, attempts were made to culture spirochetes from the urinary bladder, spleen, kidney, blood, and urine. spirochetes were most frequently isolated from the bladder (94%), followed by the kidney (75%), spleen (61%), and blood (13%). no spirochetes were isolated fr ...19883290239
use of an autologous antigen in the serologic testing of patients with erythema migrans of lyme disease.we attempted to detect an early rise in antibody titers to borrelia burgdorferi in the serum of patients with erythema migrans of lyme disease by utilizing b. burgdorferi isolates obtained from patients' own skin lesions instead of the b31 reference strain. b. burgdorferi was isolated from nine of 23 skin biopsy specimens submitted for culture. elevated antibody titers were not detected in any of the 23 acute serum samples by immunofluorescence assay. the antigens derived from patient isolates w ...19883290287
[tick-borne borrelia burgdorferi--frequent causative agent of peripheral facial paralysis]. 19883290791
lyme disease: the latest great imitator.lyme disease is caused by the spirochete b. burgdorferi. like its counterpart syphilis, it causes multisystem disease particularly affecting the skin, nervous system, heart and musculoskeletal system. it is endemic in several areas of the united states as well as in europe. the prompt recognition of this disease and its diverse manifestations should lead to early treatment and resolution. prevention is aimed at avoidance of the tick vector.19883292999
[vasculitic neuropathy in the garin-bujadoux-bannwarth syndrome. a contribution to the understanding of the pathology and pathogenesis of the neurological complications in lyme borreliosis].clinical examinations and nerve biopsies were performed on four patients with meningoradiculoneuritis and positive serology for borrelia (garin-bujadoux-bannwarth syndrome). three patients had a painful multiplex mononeuropathy, while one presented with a picture resembling a guillain-barré syndrome. nerve biopsy in two patients revealed marked perivasculitis, in part with thrombosis of the epineural vasa nervorum. in the other two patients there were small pericapillary infiltrates in the endon ...19883338392
measurement of antibodies to the borrelia burgdorferi flagellum improves serodiagnosis in lyme disease.the isolation of borrelia burgdorferi flagella and an enzyme-linked immunosorbent assay (elisa) for detection of immunoglobulin g (igg) and igm to the b. burgdorferi flagellum are described. the diagnostic performance of the flagellum elisa for serodiagnosis of lyme disease was compared with the performance of a traditional whole cell b. burgdorferi sonic extract elisa. we examined sera and cerebrospinal fluid (csf) from 56 patients with lymphocytic meningoradiculitis (bannwarth's syndrome), the ...19883343329
[prevalence of lyme borreliosis in a swiss population at risk].the epidemiology of "lyme borreliosis" in europe and the significance of positive antibody titers against borrelia burgdorferi is not well known. since "orienteering", a competitive cross country sport with a map and a compass, usually in forests, elevates the risk of being bitten by ticks and infected by b. burgdorferi, nearly 1000 orienteerers were included in a prospective study. - in this population the prevalence of positive igg-antibodies (immunofluorescence technique) was almost 20% and o ...19883344410
acrodermatitis chronica atrophicans.two cases of acrodermatitis chronica atrophicans associated with borrelia burgdorferi infection are reported; to our knowledge these are the first cases reported in children.19883348655
enzyme-linked immunosorbent assays for the detection of class-specific immunoglobulins to borrelia burgdorferi.enzyme-linked immunosorbent assays were developed to detect immunoglobulin m (igm) and immunoglobulin g (igg) antibodies to borrelia burgdorferi, the etiologic agent of lyme disease. of the 135 blood samples obtained during 1985-1986 from persons in connecticut with erythema migrans or other clinical manifestations of this spirochetosis, 106 (79%) contained igm antibody. in separate tests for igg antibody, 106 (83%) of 128 specimens were considered positive. to assess the specificity of these as ...19883354546
prevalence of ixodes dammini near the homes of lyme disease patients in westchester county, new york.cases of lyme disease that occurred in westchester county, an affluent suburb north of new york city, in 1983 were investigated in 1983 and 1984 to determine the presence of ixodes dammini (acari: ixodidae) in the vicinity of the patients' homes. small mammal trapping, drag cloth, and carbon dioxide-baited tick traps were used to sample ticks. in all but one of 11 cases investigated, i. dammini was found on or near well-maintained lawns in the immediate vicinity of the residences. a mark-release ...19883354547
plasmid analysis of borrelia burgdorferi, the lyme disease agent.a simple procedure for extraction of plasmid-enriched dna from borreliae was used in a plasmid analysis of 13 strains of the lyme disease agent, borrelia burgdorferi. the extracted dna was subjected to low-percentage agarose gel electrophoresis and examined either directly by ethidium bromide staining or after hybridization of the plasmids in situ with a dna probe for the gene encoding the major outer membrane protein ospa. each isolate had four to seven discernible plasmids of various sizes. on ...19883356787
fatal adult respiratory distress syndrome in a patient with lyme disease.a dry cough, fever, generalized maculopapular rash, and myositis developed in a 67-year-old woman; she also had markedly abnormal liver function test results. serologic tests proved that she had an infection of recent onset with borrelia burgdorferi, the agent that causes lyme disease. during a two-month course of illness, her condition remained refractory to treatment with antibiotics, salicylates, and steroids. ultimately, fatal adult respiratory distress syndrome developed; this was believed ...19883357244
hepatitis due to recurrent lyme disease. 19883358572
[schoenlein-henoch purpura in borrelia burgdorferi infection].in a 24-year-old patient suffering from recurrent purpura schoenlein-henoch, there were found positive lyme-spirochete ift. due to the motion of titres in immune fluorescence examinations the purpura seems to be likely one form of a late manifestation in borrelia infection.19883360463
[infiltrating lymphadenosis benigna cutis as borreliosis of the skin].forms of lymphadenosis benigna cutis (lbc) which run an unusual course may present considerable problems and are sometimes difficult to distinguish from malignant lymphomas of the skin on the basis of the clinical and histological picture. the case of a female patient is reported, who presented with plaque-like infiltrative lesions on both lower arms. the lesions were interpreted as being malignant lymphomas of the skin. after a progressive course of 6 years' duration, the diagnosis of an unusua ...19883360600
immunoblot analysis of immunoglobulin g response to the lyme disease agent (borrelia burgdorferi) in experimentally and naturally exposed dogs.immunoblots were used to study the immunoglobulin g response to borrelia burgdorferi in experimentally and naturally exposed dogs. adsorption studies confirmed that the antibodies were specific for b. burgdorferi. experimentally exposed dogs were asymptomatic. naturally exposed dogs included both asymptomatic animals and animals showing signs compatible with lyme disease. naturally exposed dogs were from four geographic regions of the country. no differences were detected between immunoblot patt ...19883366860
chronic central nervous system involvement in lyme borreliosis.we describe four patients with marked chronic meningoencephalomyelitis caused by tick-transmitted borrelia burgdorferi infection. imaging techniques showed either ms-like lesions or evidence of vascular involvement, as in other spirochetal infections, especially in meningovascular syphilis.19883368066
persistent intrathecal secretion of oligoclonal, borrelia burgdorferi-specific igg in chronic meningoradiculomyelitis.in the cerebrospinal fluid igg of five patients with lymphomeningoradiculitis (bannwarth's syndrome) and radiculomyelitis studied by immunoblot technique an oligoclonal pattern was found. most of these oligoclonal bands were specific for borrelia burgdorferi. in patients suffering from chronic meningoradiculomyelitis, repeated csf examination by this technique showed persistent secretion of identical igg bands. thus, the specific humoral immune response and the disease activity could be document ...19883373242
borreliosis in free-ranging black bears from wisconsin.blood, kidney and tick samples were obtained from 18 hunter-killed black bears (ursus americanus) from three sites in northern wisconsin. a borrelia sp., morphologically and antigenically similar to borrelia burgdorferi, was isolated from the blood of two of the animals, and from the kidney of a third. ixodes dammini and dermacentor variabilis were found on the bears. this is the first report of borreliosis in the ursidae, and of the primary vector of lyme disease, i. dammini, from this host.19883373646
[the epidemiology of borrelia burgdorferi infections. a pilot study from the männedorf area].only a few investigations have been conducted into the incidence of lyme borreliosis and the prevalence and clinical value of increased antibody titers against borrelia burgdorferi. we prospectively examined 241 persons and found increased titers in 23 (9.5%); only two of them had a history of lyme borreliosis. the concentrations of increased igg-antibody titers in healthy persons were comparable to those in patients with actual lyme borreliosis. in the latter, igm-antibodies were frequently abs ...19883375784
borrelia infections of ruminants in europe.the occurrence of borrelia spirochaetes in cattle in the netherlands is reported for the second time, and in red deer and roe-deer in austria for the first time. it is postulated that these spirochaetes are borrelia burgdorferi rather than b. theileri. the reservoir role of ruminants in the epidemiology of human disease caused by b. burgdorferi in europe should be investigated.19883376412
[immunochemical analysis of the immune response in late manifestations of lyme borreliosis].compared to american strains, european borrelia burgdorferi strains revealed considerable heterogeneity of major proteins. four strains isolated from ticks, human skin and human csf were selected from our 23 borrelia burgdorferi isolates. these strains and the american type strain b31 were characterized by sds-page (coomassie blue staining) and western blots (using rabbit immune sera against two of the strains and two monoclonal antibodies (h5323 and h3ts) against a major outer surface protein ( ...19883381603
serologic analyses of peromyscus leucopus, a rodent reservoir for borrelia burgdorferi, in northeastern united states.an enzyme-linked immunosorbent assay (elisa) and indirect fluorescent-antibody test were used to detect antibodies to borrelia burgdorferi, the causative agent of lyme disease, in peromyscus leucopus (white-footed mouse). of the 661 mice captured in connecticut, rhode island, and new york during 1980 and 1983 to 1987, 166 (25.1%) had antibodies to b. burgdorferi by elisa. comparative analyses of 210 serum specimens, collected in areas where lyme disease is endemic, revealed a threefold differenc ...19883384925
shulman syndrome associated with borrelia burgdorferi and complicated by carpal tunnel syndrome. 19883385049
lyme myositis: muscle invasion by borrelia burgdorferi. 19883389608
[polymyalgia rheumatica following borrelia infection].the case of a 84-year old woman is presented who developed a polymyalgia rheumatica/giant cell arteritis (pmr/gca)-syndrome following a tick bite. elevated titers of igg-antibodies (indirect immunofluorescence and elisa) as well as igm (immunoblot) against borrelia burgdorferi antigens were found in her serum. when a total of 19 patients with pmr/gca-syndrome was tested serologically, elevated or borderline igg-titers against borrelia antigens were detected in 12 of them (= 63%). hence, borrelia ...19883391633
changes in infectivity and plasmid profile of the lyme disease spirochete, borrelia burgdorferi, as a result of in vitro cultivation.in vitro cultivation of borrelia burgdorferi, the etiologic agent of lyme spirochetosis, allows for the isolation and growth of this bacterium from infected tissues. however, continuous cultivation in modified kelly medium causes a reduction in the number of detectable plasmids and the loss of infectivity in the white-footed mouse, peromyscus leucopus. in an unpassaged culture of b. burgdorferi, nine plasmids were present, including seven linear plasmids ranging in size from 49 to 16 kilobases ( ...19883397175
basal meningovasculitis and occlusion of the basilar artery in two cases of borrelia burgdorferi infection.we present two cases in which a meningovasculitis and occlusion of the basilar artery were found in young adults with a borrelia burgdorferi infection. we introduce the designation "neuroborreliosis," because both the central and peripheral nervous systems can be involved in the infection.19883399082
incompetence of deer as reservoirs of the lyme disease spirochete.to determine whether deer may serve as reservoir hosts for the lyme disease spirochete, we sought evidence of infection in nymphal ixodes dammini derived from larvae that had engorged on white-tailed deer. a total of 19 deer were shot in two lyme disease foci in massachusetts during september 1986, the season in which larvae were most abundant. an average of 342 larval ticks of this species were collected from each deer. of those that developed to the nymphal stage, the gut contents of 185 were ...19883400797
renal lesions associated with borrelia burgdorferi infection in a dog.borrelia burgdorferi infection was diagnosed serologically in a dog with lethargy, stiffness, and anorexia. treatment with ampicillin and chloramphenicol did not alleviate the signs. azotemia, proteinuria, cylindruria, pyuria, and hematuria developed over a 3-month period. antibody titer for b burgdorferi remained high (1:8,192) during this time. renal histopathologic findings included severe, chronic, diffuse, membranoproliferative glomerulonephritis and moderate chronic, multifocal, interstiti ...19883403355
the neurological complications of borrelia burgdorferi in the new forest area of hampshire.the neurological complications of borrelia burgdorferi infection have only recently been recognised in the united kingdom. eight cases are reported which were all contracted in the new forest area of hampshire. the majority of patients had bannwarth's syndrome though meningism and parenchymal lesions also occurred. all patients made a virtually complete neurological recovery in contrast to some patients with lyme disease.19883404167
borrelia burgdorferi in tick cell culture: growth and cellular adherence. 19883404544
deer ticks, ixodes dammini (acari: ixodidae), and lyme disease spirochetes, borrelia burgdorferi, in maine. 19883404548
anticardiolipin antibodies in lyme disease.sera from 28 patients with lyme disease were tested for the presence of anticardiolipin antibodies (acla). seven serum samples had elevated levels of igm acla, and 4 had elevated levels of igg acla. higher igm acla positivity tended to be associated with neurologic disease, and igm acla levels correlated with the specific igm response to the infecting spirochete (p less than 0.01). absorption experiments indicated that acla and antispirochete antibodies are largely separate populations. thus, ac ...19883408508
induction of lyme arthritis in lsh hamsters.in studies of experimental lyme disease, a major obstacle has been the unavailability of a suitable animal model. we found that irradiated lsh/ss lak hamsters developed arthritis after injection of borrelia burgdorferi in the hind paws. when nonirradiated hamsters were injected in the hind paws with b. burgdorferi, acute transient synovitis was present. a diffuse neutrophilic infiltrate involved the synovia and periarticular structures. the inflammation was associated with edema, hyperemia, and ...19883410540
first experience with elisa serosurvey for tick-borne borreliosis (lyme disease) in czechoslovakia.antibodies to borrelia burgdorferi were searched for in the sera from two groups of hospital patients and one group of healthy agricultural workers. the antibody response was measured by the authors' own modification of the elisa method employing the antigen prepared from borrelia recurrentis strain propagated in laboratory mice. positive antibody titres to borrelia were demonstrated in 5 out of the 44 patients admitted to the infectious diseases clinic, in 8 out of the 32 patients from the neur ...19883411118
susceptibility of the gray wolf (canis lupus) to infection with the lyme disease agent, borrelia burgdorferi.four juvenile gray wolves (canis lupus) were inoculated with live borrelia burgdorferi. one received an intravenous inoculum, a second was inoculated subcutaneously, and two more were fed peromyscus maniculatus sucklings which had earlier been inoculated with b. burgdorferi. the intravenously inoculated wolf developed a generalized lymphadenopathy and a persistent serum antibody titer to the spirochete which peaked at 1:512. borrelia burgdorferi was visualized in liver sections of this wolf usin ...19883411709
lyme disease patients' serum contains igm antibodies to borrelia burgdorferi that cross-react with neuronal antigens.serum from patients with neurologic manifestations of lyme disease had serum igm antibodies that bound to normal human axons, whereas binding was absent or weak in patients without neurologic findings. antiaxonal binding could be eliminated by absorption with borrelia burgdorferi. a murine monoclonal antibody to the borrelial flagellin also bound to human axons.19883412593
a murine igm monoclonal antibody binds an antigenic determinant in outer surface protein a, an immunodominant basic protein of the lyme disease spirochete.a hybridoma cell line formed by the fusion of the p3x63-ag8.653 myeloma cell line with splenocytes from balb/c mice immunized with borrelia burgdorferi produced an igm monoclonal antibody (mab-11g1) with kappa-light chains which detected an antigenic determinant in a major spirochetal protein of m.w. approximately 31,000, also known as outer surface protein a (osp-a). apparent saturation was reached in approximately 35 min with 34 ng of mab-11g1 binding to 5 x 10(7) spirochetes giving an estimat ...19882447170
[primary lymphoma of the nervous system following radiculoneuritis caused by borrelia burgdorferi: study of a case].a 50-year-old man had a primary lymphoma of the central nervous system one year after a tick bite and a radiculoneuritis secondary to borrelia burgdorferi infection. determination of antibodies against borrelia burgdorferi revealed increasing igm and igg titers, and the autopsy showed a primary b-cell immunoblastic lymphoma of the brain without evidence of extraneural lymphoproliferative disorder. lymphoma of the brain is a rare type of central nervous system cancer, and sporadic cases appear wi ...19882451279
biological activity of borrelia burgdorferi antigens.osp-a (approximately 31 kda) and flagellins (approximately 41 kda) are prominent antigens of borrelia burgdorferi. both osp-a and flagellins are immunogenic in patients and in experimentally infected mice and hamsters, but the kinetics of antibody formation to each vary considerably between the species. the role of eluted osp-a and flagellins in the cellular immune response, chemotaxigenesis, and cytoadherence was measured. eluted osp-a and flagellins stimulated the proliferation of normal and i ...19882461134
antigenic variability of borrelia burgdorferi.borrelia burgdorferi strains (six isolates from north america and 28 isolates from europe) were analyzed by physicochemical and immunological methods. by sds-page, all borrelia burgdorferi strains tested had two major proteins with constant molecular weights of 60 and 41 kda and one, two, or three variable low molecular weight proteins (ospa = 30-32 kda, ospb = 34-36 kda, pc = 21-22 kda). all combinations--except ospb alone or ospb/pc--were observed. borrelia burgdorferi strains were different f ...19882461135
isolation and characterization of borrelia burgdorferi-specific and autoreactive t-cell lines from the cerebrospinal fluid of patients with lyme meningoradiculomyelitis. 19882462820
immunochemical characterization of and isolation of the gene for a borrelia burgdorferi immunodominant 60-kilodalton antigen common to a wide range of bacteria.by crossed immunoelectrophoresis and western blotting (immunoblotting), it was shown that borrelia burgdorferi expresses the 60-kilodalton common antigen (ca) that is cross-reactive with an equivalent antigen in a wide range of remotely related bacteria. b. burgdorferi ca is strongly immunogenic. a b. burgdorferi genomic library was constructed by using a plasmid cloning system. escherichia coli recombinants were screened for expression of immunodominant b. burgdorferi antigens. one of the recom ...19882840400
borrelia burgdorferi infection: a neurologist's perspective. 19882847620
lyme disease. a review. 19883068778
lyme disease: acute focal meningoencephalitis in a child. 19883054790
paralysis of recurrent laryngeal nerve in lyme disease. 19882903968
treatment of lyme disease. 19883233968
lyme disease: a historical perspective. 19883068078
lyme disease in missouri. 19883265759
[heart involvement in lyme disease]. 19883212945
[lyme disease evolving over 12 years]. 19883212258
lyme disease: ocular manifestations.we present three cases of lyme disease, complicated by ocular manifestations. these included optic nerve abnormalities and corneal opacities.19883207308
lyme disease--the great imitator. 19883267980
antibodies to myelin basic protein in lyme disease. 19882457637
lyme disease in canada. 19883395939
[characteristics of the clinical diagnosis and treatment of tick-borne borreliosis (lyme disease)]. 19883195095
[lyme disease]. 19883070497
lyme disease. 19883405519
treatment of lyme disease. 19883380058
[some recent results and developments in dermatovenerology].our own results in dermatology are highlighted, such as the oral "hairy" leukoplakia associated with aids, treatment with acyclovir for herpetic infections, laser therapy for angiomas, lyme disease, x-ray therapy in kaposi's sarcomas, photosensitivity reactions by treatment with thiazid diuretics and follicular mucinosis associated with t-cell lymphomas (mycosis fungoides).19883210865
[lyme disease in otoneurology practice]. 19883168036
[lyme disease manifested by polyradiculoneuritis without hypercytosis of the cerebrospinal fluid]. 19882969555
lyme disease in canada. 19883250561
lyme disease: epidemiological characteristics in maryland, 1984-1986. 19883405041
tick-borne diseases.tick-borne diseases have their peak incidence in the spring and summer. the different infections caused by tick vectors have certain geographic locations and unique clinical presentations. the most common tick-transmitted infection is lyme disease. early diagnosis of tick-borne disease is essential so that effective and, in some cases, lifesaving antibiotic therapy can be instituted. preventive measures are simple.19883289344
treatment of late lyme borreliosis--randomised comparison of ceftriaxone and penicillin.23 patients with clinically active late lyme disease were randomly assigned to intravenous treatment with either penicillin or ceftriaxone. of the 10 treated with penicillin, 5 were judged treatment failures; of the 13 who received ceftriaxone, only 1 did not respond. an additional 31 patients were subsequently treated with ceftriaxone 4 g/day (n = 17) or 2 g/day (n = 14); success rates in both groups were comparable to those in the cohort randomised to ceftriaxone. patients unresponsive to ceft ...19882897008
mild lyme disease. 19882896854
[meningoradiculoencephalitis in lyme disease. a case with major regressive mental disorders]. 19882966957
bilateral diffuse choroiditis and exudative retinal detachments with evidence of lyme disease. 19883282440
british columbia. lyme disease in horses. 198817423037
[crossed reactions in lyme disease. value of the western blot]. 19882965350
[from tick bite to lyme disease: evolution of a clinical concept]. 19883287542
[lyme disease: its principal neurological and rheumatological aspects]. 19883259708
lyme disease--connecticut. 19883233680
[lyme disease with multiple joint involvement and a major inflammatory syndrome]. 19882966360
leads from the mmwr. lyme disease--connecticut. 19883276944
[lyme disease in pregnancy]. 19883370692
multiple sclerosis is a chronic central nervous system infection by a spirochetal agent.multiple sclerosis (ms) is a chronic central nervous system (cns) infection similar to lyme disease or neurosyphilis in its latency period, pathogenesis, symptoms, histopathology and chronic cns involvement. it does not have as yet a fully identified spirochetal etiological agent. much research and clinical support for this hypothesis was published before 1954 and is based on silver staining of neural lesions, animal isolation of the etiologic agent and the characteristic symptoms and pathogenes ...19883357458
pattern of lyme arthritis in europe: report of 14 cases.fourteen cases of lyme arthritis are reported. the most frequent picture was that of oligoarthritis appearing in that part of the leg where the cutaneous or neurological complications, or both, of lyme disease had developed before the arthritis. in most cases recovery followed a single 10 day course of intravenous (iv) penicillin therapy. arthritis was the presenting feature of lyme disease in three cases.19883355251
possible pitfalls of an indirect immunofluorescence assay as the sole serological test in the diagnosis of lyme disease. 19883132389
bilateral keratitis as a manifestation of lyme disease.an 11-year-old girl developed bilateral keratitis, which we believe was a manifestation of lyme disease. she had had several attacks of lyme arthritis and was twice treated with parenteral penicillin. the keratitis developed five years after the initial episode of lyme arthritis at a time when there were no other manifestations of lyme disease. it cleared completely in both eyes after topical corticosteroid therapy.19883337196
lyme disease--connecticut. 19883122001
lyme disease treatment needs further preventive measures. 19883347018
[rheumatologic manifestations of lyme disease].the characteristics of 15 patients with lyme disease have been retrospectively reviewed; 12 patients had lymphocytic meningitis with mono or polyradiculitis including facial neuritis; 5 patients had mono or oligo-arthritis; 4 patients had inflammatory enthesopathy-like complaints which were the only expression of the disease in 2 of them. all the patients received antibiotic treatment. a dramatic clinical improvement was noted in all patients within four days. a rapid response to treatment seems ...19883266722
[lyme disease and hla-dr antigens: relation between hla-dr2 and hla-dr4]. 19883258452
analogous cases of lyme disease. 19883234981
otoneurological symptomatology in lyme disease. 19883213733
treatment of erythema chronicum migrans of lyme disease.between june 1981 and july 1987 the efficacy of antibiotic treatment of 215 patients with erythema chronicum migrans of lyme disease was evaluated in terms of the necessity for retreatment and the prevention of the late manifestations of lyme disease. the principal antibiotics utilized to treat 161 patients through 1986 were varying doses of tetracycline, or penicillin alone or in combination with probenecid. two of 80 patients with a minor form of the illness and 17 of 81 patients with a major ...19883190102
nervous system abnormalities in lyme disease. 19883190096
[lesions of the joints in lyme disease]. 19883062804
[lyme disease]. 19882977898
clinical pathologic correlations of lyme disease by stage.lyme disease is capable of producing a wide variety of clinical pathologic conditions and lesions having in common histologic features of collagen-vascular disease. the plasma cell is an omnipotent inflammatory responder in most tissues involved by lyme disease, ranging from relatively acute to lesions that have gone on for years. vascular thickening also seems to be prominent, and in the dermis is accompanied by scleroderma-like collagen expansion. the disease in some ways resembles the respons ...19882847622
lyme disease.lyme disease is of interest to the neurologist and neuroscientist for a variety of reasons. as more arthropod hosts throughout the world are infected with the causative organism, borrelia burgdorferi, the illness in humans is becoming more prevalent; in addition, recognition of the disease in humans and susceptible animals is increasing. the neurological manifestations include acute and chronic forms, and it has become clear that b. burgdorferi has joined treponema pallidum, herpes simplex virus ...19892472690
shared flagellar epitopes of borrelia burgdorferi and borrelia anserina.antigenic cross-reactivity between borrelia burgdorferi and borrelia anserina was studied using mouse immune sera and monoclonal antibodies. with immune sera, significant cross-reactivity between b. burgdorferi and b. anserina was demonstrated by indirect immunofluorescent assay. in immunoblots, most of the cross-reactivity was shown to be associated with the periplasmic flagella. using monoclonal antibodies in immunoblots, it was shown that b. burgdorferi and b. anserina shared at least two fla ...19892473569
immune responses to borrelia burgdorferi in patients with reactive arthritis.in reactive arthritis (rea), including reiter's syndrome, a close relationship between chronic enteric and genitourinary infections and the clinical features of enthesitis has been described. in contrast, in lyme arthritis, a distinct clinical entity, chronic infection with the tick-transmitted spirochete borrelia burgdorferi has been associated with the disease. in a prospective study, 51 patients with rea were tested for evidence of chlamydial and spirochetal infection. the presence of chlamyd ...19892476133
temporary pacing in complete heart block due to lyme disease: a case report.the authors present the case of a 44-year-old man who was admitted with complete heart block and signs of severe bradycardia. after steroid administration and temporary pacemaker treatment the complete heart block resolved. during this therapy transient st segment and t wave abnormalities occurred. the positive borrelia burgdorferi antibody titer arrived only after therapy had been completed. this is regarded as the first case of lyme carditis with complete heart block diagnosed in eastern europ ...19892476769
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